Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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脳内転写制御因子CREB, AP-1のDNA結合活性に及ぼすドパミンレセプター作用薬の影響.

浅沼幹人

Prog. Med. 17 ( 2 ) 423 - 430 1997.2

Protective effects of FK506 on the late-onset reduction of muscarinic acetylcholine receptors in gerbil hippocampus after transient forebrain ischemia Reviewed

Sakiko Nishibayashi, Yoichi Kondo, Masato Asanuma, Emi Iwata, Marvin Gomez-Vargas, Norio Ogawa

Journal of Brain Science 23 ( 1 ) 33 - 40 1997

Language：English Publishing type：Research paper (scientific journal) Publisher：JAPAN BRAIN SCI SOC

Late-onset reduction of muscarinic acetylcholine receptors (LORMAR) in the ischemic gerbil hippocampus begins as late as 7 days after a 5-min transient forebrain ischemia and reperfusion. We previously reported that LORMAR is prevented by postadministration of cyclosporin A. In the present study, we aim to elucidate whether the LORMAR can also be prevented by post-ischemic administration of the immunosuppressant FK506 (tacrolimus). We investigated changes in muscarinic acetylcholine receptor binding capacity and histological examination in the transient forebrain ischemic gerbil hippocampus and the effect of this agent on these changes. In the ischemic vehicle-treated group, muscarinic acetylcholine receptors significantly decreased in the hippocampus as the LORMAR with subsequent disruption of the pyramidal cells in the CA1 area. On the other hand, LORMAR is prevented by daily subcutaneous administration of low dose of FK506 (0.5 mg/kg/day) for 10 days after the ischemic insult, although delayed neuronal cell death was not prevented. Thus, we showed that the LORMAR is attenuated by post-administration of FK506.

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神経細胞死と活性酸素・フリーラジカル.. Invited

小川紀雄, 近藤洋一, 岩田恵美, 浅沼幹人, 飯田基之

フリーラジカルの臨床 11 101 - 106 1997

Chronic administration of Oren-gedoku-to (TJ15) inhibits ischemic-induced changes in brain indoleamine metabolism and muscarinic receptor binding in the Mongolian gerbil Reviewed

Hideaki Kabuto, Masato Asanuma, Sakiko Nishibayashi, Motoyuki Iida, Norio Ogawa

Neurochemical Research 22 ( 1 ) 33 - 36 1997

Effects of Lecithinized SOD on Contusion Injury in Rats Reviewed

Masatoshi Yunoki, Yasuhiro Noguchi, Shinsaku Nishio, Yasuhiro Ono, Masamitsu Kawauchi, Shoji Asai, Takashi Ohmoto, Masato Asanuma, Norio Ogawa

Acta Neurochir Suppl 70 182 - 184 1997

Aniracetam ameriorates impaired pre- and post-synaptic cholinergic indices in gerbil hippocampus induced by transient forebrain ischemia Reviewed

Yoichi Kondo, Masato Asanuma, Hideaki Kabuto, Emi Iwata, Fumio Kondo, Ikuko Miyazaki, Norio Ogawa

Journal of Brain Science 23 ( 4 ) 250 - 260 1997

Scavenging Effects of Dopamine Agonists on Nitric Oxide Radicals Reviewed

Sakiko Nishibayashi, Masato Asanuma, Masahiro Kohno, Marvin Gómez-Vargas, Norio Ogawa

Journal of Neurochemistry 67 ( 5 ) 2208 - 2211 1996.11

Alterations of cAMP response element-binding activity in the aged rat brain in response to administration of rolipram, a cAMP-specific phosphodiesterase inhibitor Reviewed

Masato Asanuma, Sakiko Nishibayashi, Emi Iwata, Yoichi Kondo, Tohru Nakanishi, Marvin Gómez Vargas, Norio Ogawa

Molecular Brain Research 41 ( 1-2 ) 210 - 215 1996.9

Relationship between cholinergic dysfunction and discrimination learning disabilities in Wistar rats following chronic cerebral hypoperfusion Reviewed

Ken-ichi Tanaka, Norio Ogawa, Masato Asanuma, Yoichi Kondo, Masahiko Nomura

Brain Research 729 ( 1 ) 55 - 65 1996.8

Language：English Publishing type：Research paper (scientific journal) Publisher：ELSEVIER SCIENCE BV

The effects of chronic hypoperfusion of cerebral blood flow (CBF) on central cholinergic indices and intellectual functions were investigated in rats. Male Wistar rats, aged 9 weeks, were anesthetized with pentobarbital, and the bilateral common carotid arteries were permanently ligated. Cortical CBF in the hypoperfused rats was markedly decreased at 6 weeks after the operation. In the hypoperfused group, cholinergic indices were changed to consist two phases after the operation, before (acute) and after (chronic) 6 weeks after the operation. At 6 weeks, choline acetyltransferase activity was restored to the sham-operated level compared with the changes in the frontal cortex and thalamus + midbrain at 3 weeks. On the other hand, the maximum number of muscarinic acetylcholine receptors was reduced in the frontal cortex, hippocampus and striatum at 6 weeks and thereafter remained at this low level. In discrimination learning task, the percentage of correct responses in the hypoperfused rats was generally reduced in contrast with that of the sham-operated rats, although the number of total responses were not changed. As a consequence, cholinergic dysfunctions correlate with discrimination learning disabilities in the hypoperfused rats. These findings suggest that the hypoperfused rat may be useful for the cerebrovascular type dementia model to clarify pathophysiology.

DOI： 10.1016/S0006-8993(96)00400-3

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Effects of Bromocriptine on Dopamine Turnover with or without Levodopa Reviewed

Norio Ogawa, Masato Asanuma, Ken-ichi Tanaka, Koji Matsuura, Kyoko Iida, Mitsutoshi Yamamoto

Journal of International Medical Research 24 ( 3 ) 271 - 277 1996.5

Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Bromocriptine, a dopamine agonist, alleviates symptoms of Parkinson's disease, even when administered alone, and is used for its treatment. Better therapeutic effects are, however, achieved when bromocriptine is used in combination with levodopa. In this study, we examined the biochemical changes caused by bromocriptine administration with and without levodopa, and evaluated the effects of the treatments on dopamine turnover in the mouse striatum. Results show that dopamine turnover is suppressed by the administration of bromocriptine alone with a slight decrease in the amount of dopamine, and dopamine turnover is very strongly promoted by the administration of levodopa. When the two drugs are administered together, bromocriptine enhances the levodopa-induced increase in dopamine turnover in the striatum. These findings indicate that bromocriptine therapy in combination with levodopa enhances the dopaminergic function and suggest that the combination therapy of bromocriptine and levodopa shows good efficacy. The results of this study may, thus, provide a theoretical basis for the combination therapy of bromocriptine and levodopa.

DOI： 10.1177/030006059602400306

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L-DOPA合剤の変更による老齢パーキンソン病患者の問題症状の改善 Invited

浅沼幹人

老化と疾患 9 ( 4 ) 521 - 525 1996.4

Expression of mRNA encoding neurotrophic factors and its regulation in a hybrid neuronal cell line Reviewed

Tohru Nakanishi, Kazuhiro Ishii, Nobuyuki Fukushima, Masato Asanuma, Emi Iwata, Norio Ogawa

Biochemistry and Molecular Biology International 38 ( 4 ) 763 - 772 1996.4

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS AUST

In a cultured hybrid neuronal cell line (BIM) which was produced between human neuroblastoma cells (IMR32) and thymidine auxotrophs (B3T) of rat nerve-like cells (B103), the mRNAs encoding ciliary neurotrophic factor (CNTF) and neurotrophins were detected by the polymerase chain reaction method. The conditioned medium of BIM cells enhanced choline acetyltransferase (ChAT) activity in septal neurons and survival of-ciliary ganglion neurons. The mRNA expression of CNTF and neurotrophins in BIM cells was differently regulated by the stimulation with cAMP, FGF and retinoic acid. These data suggest multiple regulation and collaboration of neurotrophic factors.

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Preventive effects of bifemelane hydrochloride on decreased levels of muscarinic acetylcholine receptor and its mRNA in a rat model of chronic cerebral hypoperfusion Reviewed

Yoichi Kondo, Norio Ogawa, Masato Asanuma, Koji Matsuura, Sakiko Nishibayashi, Emi Iwata

Neuroscience Research 24 ( 4 ) 409 - 414 1996.3

Long-term time course of regional changes in cholinergic indices following transient ischemia in the spontaneously hypertensive rat brain Reviewed

Norio Ogawa, Masato Asanuma, Ken-ichi Tanaka, Hiroshi Hirata, Yoichi Kondo, Masaki Goto, Masamitsu Kawauchi, Toshio Ogura

Brain Research 712 ( 1 ) 60 - 68 1996.3

Age-related changes in composition of transcription factor, AP-1 complex in the rat brain Reviewed

Masato Asanuma, Yoichi Kondo, Sakiko Nishibayashi, Emi Iwata, Tohru Nakanishi, Norio Ogawa

Neuroscience Letters 201 ( 2 ) 127 - 130 1995.12

脳の老化と生化学 Invited

浅沼幹人, 小川紀雄

臨床と研究 72 ( 11 ) 2654 - 2658 1995.11

High DNA-binding activity of transcription factor NF-κB in synovial membranes of patients with rheumatoid arthritis. Reviewed

Hiroshi Asahara, Masato Asanuma, Norio Ogawa, Sakiko Nishibayashi, Hajime Inoue

Biochemistry and Molecular Biology International 37 ( 5 ) 827 - 832 1995.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ACADEMIC PRESS AUST

Our objective was to clarify the DNA-binding activity of transcription factor NF-kappa B as related to cytokine induction in the synovium of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Synovial membranes were obtained during arthroplasty of the knee from 7 patients with RA and 4 patients with OA. Nuclear extracts obtained from the synovial membranes were examined by electrophoretic mobility shift assay to determine the DNA-binding activity of NF-kappa B. Markedly high DNA-binding activity of NF-kappa B was detected in the synovial membranes of RA patients, while virtually no activity was observed in those of OA patients. These results suggest that the high induction of NF-kappa B in the nuclear extracts may be relatively specific to synovial membranes in RA. NF-kappa B may regulate the production of cytokines at the site of synovial inflammation.

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Effects of single cyclosporin A pretreatment on pentylenetetrazol-induced convulsion and on TRE-binding activity in the rat brain Reviewed

Masato Asanuma, Sakiko Nishibayashi, Yoichi Kondo, Emi Iwata, Masaaki Tsuda, Norio Ogawa

Molecular Brain Research 33 ( 1 ) 29 - 36 1995.10

M1 Receptors in Blood Pressure–Controlled Ischemic Spontaneously Hypertensive Rats Reviewed

Hiroshi Hirata, Masato Asanuma, Ken-ichi Tanaka, Yoichi Kondo, Norio Ogawa

Stroke 26 ( 7 ) 1268 - 1272 1995.7

Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

<italic>Background and Purpose</italic>
Hypertension is a primary aggravating factor in cerebral infarction. An acute rise in blood pressure (BP) at the time of a stroke may be harmful to the brain in a hypertensive subject because both cerebral vascular structure and function are altered by hypertension. Muscarinic M
₁
receptors are concerned with memory and learning. We aimed to evaluate the effect of controlling BP in hypertensive subjects at the time of stroke with a biochemical index of brain damage.

<italic>Methods</italic>
We gave a single dose of either the antihypertensive α-blocker phentolamine (2 mg/kg IP) or the calcium antagonist nicardipine (2 mg/kg IP) at the start of bilateral carotid artery occlusion to spontaneously hypertensive rats undergoing 3 hours of transient ischemia; we measured the time course of mean BP (MBP) and changes in the M
₁
receptor and its mRNA in three brain regions 2 weeks after the transient ischemia.

<italic>Results</italic>
Administration of phentolamine or nicardipine not only significantly suppressed the ischemia-induced rise of MBP, it actually decreased MBP during ischemia. In an ischemic control group, M
₁
receptor binding decreased in the frontal cortex and M
₁
receptor mRNA increased in the hippocampus 2 weeks after the ischemia. In contrast, both phentolamine- and nicardipine-treated ischemic rats showed no changes in either index compared with sham-operated controls.

<italic>Conclusions</italic>
Controlling BP during an ischemic insult attenuates ischemia-induced damage of M
₁
receptors in the brain of spontaneously hypertensive rats. These results suggest that a rapid intensive increase of BP at the time of a stroke may exacerbate brain damage in hypertensive individuals.

DOI： 10.1161/01.str.26.7.1268

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神経変性過程における免疫制御薬シクロスポリンAの効果 Invited

小川紀雄, 浅沼幹人

Dementia 9 ( 2 ) 153 - 161 1995.4

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