Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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Rotenone induces disassembly of the Golgi apparatus in the rat dopaminergic neuroblastoma B65 cell line Reviewed

Francisco J. Diaz-Corrales, Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

Neuroscience Letters 354 ( 1 ) 59 - 63 2004.1

遺伝子改変によるパーキンソン病モデル． Invited

浅沼幹人, 宮崎育子

脳の科学 292 ( 2004年増刊号 ) 165 - 170 2004

β遮断薬による心不全・不整脈治療の基礎と臨床ーカルベジロールを中心としてーβ遮断薬と酸化ストレス． Reviewed

中村一文, 垣下幹夫, 草野研吾, 三浦綾, 久松研一, 永瀬聡, 森田宏, 斉藤博則, 江森哲郎, 浅沼幹人, 小川紀雄, 宮崎正博, 中村陽一, 松原広己, 伏見和郎, 豊國伸哉, 大江透

心電図 24 ( 1 ) 15 - 21 2004

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：(一社)日本不整脈心電学会

欧米における大規模臨床試験の結果は,β遮断薬が慢性心不全の生命予後改善のみならず,突然死も有意に抑制することを明らかにした.しかし,患者背景の異なる我が国における,β遮断薬の有効性は必ずしも明確ではない.そこで,著者等の自験例を基に,致死性不整脈患者或いは慢性心不全患者に対するカルベジロールを中心としたβ遮断薬の予後に対する影響及び突然死予防効果,その機序について検討した

DOI： 10.5105/jse.24.15

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00681&link_issn=&doc_id=20040205230006&doc_link_id=%2Fdn4eleca%2F2004%2F002401%2F007%2F0032-0039%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdn4eleca%2F2004%2F002401%2F007%2F0032-0039%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Direct Evidence for Increased Hydroxyl Radicals in Angiotensin II-induced Cardiac Hypertrophy through Angiotensin II Type 1a Receptor Reviewed International journal

Mikio Kakishita, Kazufumi Nakamura, Masato Asanuma, Hiroshi Morita, Hironori Saito, Kengo Kusano, Yoichi Nakamura, Tetsuro Emori, Hiromi Matsubara, Takeshi Sugaya, Norio Ogawa, Tohru Ohe

Journal of Cardiovascular Pharmacology 42 ( Suppl 1 ) S67 - S70 2003.12

Language：English Publishing type：Research paper (scientific journal) Publisher：Ovid Technologies (Wolters Kluwer Health)

Oxidative stress is known to contribute to numerous cardiac disease processes. However, the contribution of reactive oxygen species to cardiac hypertrophy has not yet been fully investigated. The aim of the present study was therefore to determine whether levels of reactive oxygen species were increased in angiotensin II-induced cardiac hypertrophy. We continuously administered angiotensin II (1.1 mg/kg per day) into wild-type and angiotensin II type-1a receptor knockout mice for 2 weeks. The angiotensin II treatment increased blood pressure and heart weight/body weight ratio in wild-type mice but not in knockout mice. The generation of hydroxyl radicals in heart tissue homogenate was directly assessed with electron spin resonance spectroscopy using a spin trapping agent, alpha-phenyl-N-tert butylnitrone. Angiotensin II significantly increased hydroxyl radical production 2.2-fold (p < 0.01) in the hearts of wildtype mice but not in knockout mice. The present study provided direct evidence for increased production of hydroxyl radicals in angiotensin II-induced cardiac hypertrophy through angiotensin II type-1a receptor. These findings in this study may provide important insights into the development of hypertrophy and the transition of hypertrophy to heart failure.

DOI： 10.1097/00005344-200312001-00015

Web of Science

PubMed

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Methamphetamine-induced neurotoxicity in mouse brain is attenuated by ketoprofen, a non-steroidal anti-inflammatory drug Reviewed

Masato Asanuma, Takeshi Tsuji, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa

Neuroscience Letters 352 ( 1 ) 13 - 16 2003.11

ドパミンおよびその誘導体のキノン体生成を介したアポトーシス誘導性．

浅沼幹人, 宮崎育子, Haque ME, 東洋一郎, 小川紀雄

Prog Med 23 ( 10 ) 2736 - 2741 2003.10

Overexpression of Cu–Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level Reviewed

M.Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

Neuroscience Research 47 ( 1 ) 31 - 37 2003.9

Apoptosis-inducing neurotoxicity of dopamine and its metabolites via reactive quinone generation in neuroblastoma cells Reviewed

M Emdadul Haque, Masato Asanuma, Youichirou Higashi, Ikuko Miyazaki, Ken-ichi Tanaka, Norio Ogawa

Biochimica et Biophysica Acta - General Subjects 1619 ( 1 ) 39 - 52 2003.1

Dopamine- or L-DOPA-induced neurotoxicity: The role of dopamine quinone formation and tyrosinase in a model of Parkinson’s disease Reviewed

Masato Asanuma, Ikuko Miyazaki, Norio Ogawa

Neurotoxicity Research 5 ( 3 ) 165 - 176 2003.1

非ステロイド性消炎鎮痛薬の神経保護作用の新展開. Reviewed

浅沼幹人, 宮崎育子, 辻武史, 小川紀雄

日本神経精神薬理学会雑誌 23 ( 3 ) 111 - 119 2003

アルツハイマー病脳で減少しているgrowth inhibitory factor (GIF) の加齢にともなう変化．

浅沼幹人, 宮崎育子, 東洋一郎, 田中健一, 小川紀雄

分子精神医学 3 ( 1 ) 69 - 70 2003

The p53-activated Gene, PAG608, Requires a Zinc Finger Domain for Nuclear Localization and Oxidative Stress-induced Apoptosis Reviewed

Youichirou Higashi, Masato Asanuma, Ikuko Miyazaki, M. Emdadul Haque, Naoko Fujita, Ken-ichi Tanaka, Norio Ogawa

Journal of Biological Chemistry 277 ( 44 ) 42224 - 42232 2002.11

テトラサイクリン誘導体ミノサイクリンの種々の神経障害に対する保護作用． Invited

浅沼幹人

ファルマシア 38 ( 11 ) 1105 - 1106 2002.11

Ikuko Miyazaki, Masato Asanuma, Youichirou Higashi, Chiharu Aoki Sogawa, Ken-ichi Tanaka, Norio Ogawa

Neuroscience Research 43 ( 4 ) 323 - 333 2002.8

Aggravation of 6-hydroxydopamine-induced dopaminergic lesions in metallothionein-I and -II knock-out mouse brain Reviewed

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Ken-ichi Tanaka, Md Emdadul Haque, Naoko Fujita, Norio Ogawa

Neuroscience Letters 327 ( 1 ) 61 - 65 2002.7

The dopamine agonist cabergoline provides neuroprotection by activation of the glutathione system and scavenging free radicals Reviewed

Michiyo Yoshioka, Ken-ichi Tanaka, Ikuko Miyazaki, Naoko Fujita, Youichirou Higashi, Masato Asanuma, Norio Ogawa

Neuroscience Research 43 ( 3 ) 259 - 267 2002.7

Methamphetamine-induced increase in striatal p53 DNA-binding activity is attenuated in Cu,Zn-superoxide dismutase transgenic mice Reviewed

Masato Asanuma, Ikuko Miyazaki, Youichirou Higashi, Jean Lud Cadet, Norio Ogawa

Neuroscience Letters 325 ( 3 ) 191 - 194 2002.6

ニューロメラニン合成酵素チロシナーゼのドパミン神経障害への関与．

浅沼幹人, 東洋一郎, 宮崎育子, 小川紀雄

Prog Med 22 ( 1 ) 212 - 215 2002.1

Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals Reviewed

Masato Asanuma, Sakiko Nishibayashi-Asanuma, Ikuko Miyazaki, Masahiro Kohno, Norio Ogawa

Journal of Neurochemistry 76 ( 6 ) 1895 - 1904 2001.3

Delta opioid peptide [D-Ala2, D-Leu5]enkephalin causes a near complete blockade of the neuronal damage induced by a single high dose of methamphetamine: Examining the role of p53 Reviewed

Teruo Hayashi, Hiroshi Hirata, Masato Asanuma, Bruce Ladenheim, Li-I Tsao, Jean Lud Cadet, Tsung-Ping Su

Synapse 39 ( 4 ) 305 - 312 2001.3

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Papers - ASANUMA Masato