Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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Chronic Lisuride Hydrogen Maleate Administration Enhances Muscarinic Receptor Binding in Senescent Rat Brain Reviewed

Hiroshi Hirata, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori, Zensuke Ota

Journal of International Medical Research 19 ( 4 ) 318 - 325 1991.7

Language：English Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

Changes in the regional density of muscarinic-1 (M₁) receptors and the effect of lisuride hydrogen maleate on these changes were studied in senescent rat brain by in vitro autoradiography. In young adult controls, M₁ receptor binding was most dense in the striatum and hippocampus, followed by the cerebral cortex and amygdala. Binding to M₁ receptors was markedly lower in these areas of the senescent brain compared with the young adult brain. These decreases were reversed by intraperitoneal administration of 50 μg/kg·day lisuride for 14 days. The present results indicate that the therapeutic efficacy of lisuride depends on normalization of not only monoamine systems but also acetylcholine systems.

DOI： 10.1177/030006059101900404

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脳血管障害後遺症における意欲低下・問題行動に対する塩酸インデロキサジンの改善効果

浅沼幹人, 平田洋, 高山晴彦, 更井哲夫, 小川紀雄

Prog. Med. 11 ( 6 ) 1527 - 1530 1991.6

イブジラストの脳梗塞症例における脳血流改善作用-SPECTを用いて-

高山晴彦, 浅沼幹人, 佐藤博彦, 平田洋, 太田善介, 小川紀雄

臨床と研究 68 ( 6 ) 1857 - 1862 1991.6

Loss of N-methyl-d-aspartate (NMDA) receptor binding in rat hippocampal areas at the chronic stage after transient forebrain ischemia: Histological and NMDA receptor binding studies Reviewed

Norio Ogawa, Kumiko Haba, Kiminao Mizukawa, Masato Asanuma, Hiroshi Hirata, Akitane Mori

Neurochemical Research 16 ( 5 ) 519 - 524 1991.5

Chronic bifemelane hydrochloride administration enhances muscarinic cholinergic recepotr binding in the senescent rat brain Reviewed

Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Masato Asanuma, Akitane Mori

Journal of Medicine 22 ( 1 ) 17 - 27 1991.1

Language：English Publishing type：Research paper (scientific journal) Publisher：P J D PUBLICATIONS LTD

In senescent rats, the binding ability of muscarinic cholinergic receptors (MCR) was markedly decreased in the cerebral cortex, hippocampus, thalamus, and the striatum compared with young adult rats. This decrease was markedly improved by chronic administration of bifemelane hydrochloride (bifemelane). In view of the findings that bifemelane markedly inhibits the decrease in acetylcholine (ACh) associated with cerebral ischemia, and that it improves amnesia induced by scopalamine, it may be inferred that bifemelane between in situ malignant melanoma and other melanin-containing in situ malignancies has been presented. All types of malignant melanoma which originate within the epidermis or epithelium have an in situ phase and show horizontal growth, and small early forms defy classification. The classification of the most common types of malignant melanoma has been revised. Although the level of invasion and tumor thickness are useful prognostic and therapeutic parameters, their determination is crude and subject to several shortcomings.

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レセルピン慢性投与のアセチルコリン系神経機構に及ぼす影響 Reviewed

浅沼幹人, 羽場久美子, 小川紀雄, 森昭胤

Neurosciences 17 ( 1 ) 87 - 90 1991.1

パーキンソン病 Invited

浅沼幹人, 小川紀雄

Brain Medical 3 ( 4 ) 351 - 358 1991

Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia Reviewed

Norio Ogawa, Kumiko Haba, Masato Asanuma, Kiminao Mizukawa, Akitane Mori

Advances in Experimental Medicine and Biology 287 343 - 347 1991

Chronic administration of bifemelane hydrochoride increases somatostatin receptor binding in aged rat brain

H. Sato, K. Mizukawa, N. Ogawa, M. Asanuma, H. Takayama, Z. Ota

Japanese Journal of Geriatrics 28 ( 1 ) 18 - 23 1991

神経ペプチドとレセプター

小川紀雄, 浅沼幹人, 羽場久美子

内分泌学の進歩 8 55 - 74 1991

Regional responses of rat brain opioid receptors upon castration and testosterone replacement Reviewed

Haruhiko Takayama, Norio Ogawa, Masato Asanuma, Zensuke Ota

Research Communications in Chemical Pathology and Pharmacology 70 ( 3 ) 355 - 358 1990.12

Language：English Publishing type：Research paper (scientific journal) Publisher：P J D PUBLICATIONS LTD

Regional responses of rat brain opioid receptors (Op-Rs) upon castration and testosterone replacement were studied using [H-3]naloxone (NAL) binding for u-type and [H-3]D-Ala2-methionine-enkephalin (ENK) binding for delta-type Op-R. Castration itself produced an increase in specific NAL and ENK binding in the olfactory bulb and thalamus+midbrain. In the hypothalamus, specific ENK binding was increased without any change in NAL binding. After the testosterone replacement in castrated rats, specific NAL binding was decreased and returned to the control level in the thalamus+midbrain, but remained high in the olfactory bulb. Specific ENK binding was decreased and returned to the control level in the olfactory bulb, hypothalamus and thalamus+midbrain. These results indicated that there are regional differences between u- and delta-type Op-R responses to castration and testosterone replacement. Op-R subtypes were regulated differentially by endogenous hormonal changes, such as testosterone.

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老齢ラットにおけるNMDAレセプターの減少とBifemelane Hydrochloride投与による回復

小川紀雄, 水川公直, 羽場久美子, 浅沼幹人

Geriat. Med.（老年医学） 28 ( 12 ) 1845 - 1849 1990.12

Alterations of somatostatin and its modulation by levodopa in MPTP-treated mouse brain Reviewed

Masato Asanuma, Norio Ogawa, Yukiko H. Sora, Khitisak Pongdhana, Kumiko Haba, Akitane Mori

Journal of the Neurological Sciences 100 ( 1-2 ) 155 - 160 1990.12

Effects of chronic administration of mergocryptine on changes in neurotransmitter levels in the ischemic gerbil brain. Reviewed

Norio Ogawa, Kumiko Haba, Masato Asanuma, Mitsuhiro Kawata, Akitane Mori

Archives Internationales de Pharmacodynamie et de Therapie 308 ( 1-2 ) 21 - 31 1990.11

Language：English Publishing type：Research paper (scientific journal) Publisher：ARCH INT PHARMACODYNAMIE

Changes in various neurotransmitter systems of the gerbil brain during ischemia and the effects of administration of mergocryptine, a new ergot derivative, were studied. Gerbils intraperitoneally administered 0.5 mg/kg of mergocryptine or the vehicle once a day for 14 days were used. The administration of mergocryptine to control animals had no effect on the contents of neurotransmitters or their metabolites in various regions of the brain, but it corrected abnormalities in the neurotransmitter systems caused by ischemia. These results suggest the usefulness of mergocryptine against the deleterious effects of brain ischemia.

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塩酸フルナリジンの線条体D2ドーパミンレセプターに対する作用 Reviewed

小川紀雄, 浅沼幹人, 高山晴彦, 佐藤博彦, 貫名至

臨床神経学 30 ( 11 ) 1221 - 1226 1990.11

Comparison of formaldehyde-preperfused frozen and freshly frozen tissue preparation for the in situ hybridization for alpha-tubulin messenger RNA in the rat brain Reviewed

Masato Asanuma, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Akitane Mori

Research Communications in Chemical Pathology and Pharmacology 70 ( 2 ) 183 - 192 1990.11

ニューロトランスミッターとドプス-パーキンソン病治療薬としての基礎と臨床- Invited

小川紀雄, 浅沼幹人

薬の知識 41 ( 3 ) 3 - 8 1990.3

老齢ラット脳におけるアセチルコリン系神経機構障害とnicergolineによる補正

小川紀雄, 水川公直, 羽場久美子, 浅沼幹人

Geriat. Med.（老年医学） 27 ( 8 ) 1198 - 1204 1989.8

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