Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

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Changes in Metallothionein Isoform Expression in the Bones of Ovariectomized Rats Reviewed

Chiharu Sogawa, Mika Ikegame, Ikuko Miyazaki, Toshiaki Ara, Yasuhiro Imamura, Yuka Okusha, Kazumi Ohyama, Masato Asanuma, Norio Sogawa, Toshio Yamamoto, Ken-ichi Kozaki

Journal of Hard Tissue Biology 25 ( 1 ) 21 - 26 2016

Serotonin-1A agonist 8-OH-DPAT alleviates motor dysfunction and motor neuron degeneration in a model of amyotrophic lateral sclerosis. Reviewed

Ikuko Miyazaki, Shinki Murakami, Takashi Nakano, Nao Torigoe, Ryo Kikuoka, Yoshihisa Kitamura, Toshiaki Sendo, Masato Asanuma

Annals of Pharmacology and Pharmaceutics 1 ( 1 ) 1003 2016

Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease Reviewed

Ikuko Miyazaki, Masato Asanuma

Current Medicinal Chemistry 23 ( 7 ) 686 - 700 2016

Doxorubicin and cyclophosphamide treatment produces anxiety-like behavior and spatial cognition impairment in rats: Possible involvement of hippocampal neurogenesis via brain-derived neurotrophic factor and cyclin D1 regulation Reviewed

Yoshihisa Kitamura, Sayo Hattori, Saori Yoneda, Saori Watanabe, Erika Kanemoto, Misaki Sugimoto, Toshiki Kawai, Ayumi Machida, Hirotaka Kanzaki, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

Behavioural Brain Research 292 184 - 193 2015.10

Long-Term Systemic Exposure to Rotenone Induces Central and Peripheral Pathology of Parkinson’s Disease in Mice Reviewed

Shinki Murakami, Ikuko Miyazaki, Ko Miyoshi, Masato Asanuma

Neurochemical Research 40 ( 6 ) 1165 - 1178 2015.6

Possible involvement of iron-induced oxidative insults in neurodegeneration Reviewed

Takeshi Asano, Masato Koike, Shin-ichi Sakata, Yukiko Takeda, Tomoko Nakagawa, Taku Hatano, Satoshi Ohashi, Manabu Funayama, Kenji Yoshimi, Masato Asanuma, Shinya Toyokuni, Hideki Mochizuki, Yasuo Uchiyama, Nobutaka Hattori, Kazuhiro Iwai

Neuroscience Letters 588 29 - 35 2015.2

Evaluation of drug-dependence liabilities and cytotoxicities of harmine : Harmful effects of hallucinogenic alkaloids found in plants

61 ( 28 ) 61 - 72 2015

Visualization of Astrocytic Primary Cilia in the Mouse Brain by Immunofluorescent Analysis Using the Cilia Marker Arl13b Reviewed

Kyosuke Kasahara, Ko Miyoshi, Shinki Murakami, Ikuko Miyazaki, Masato Asanuma

Acta Medica Okayama 68 ( 6 ) 317 - 322 2014.12

Methylphenidate improves learning impairments and hyperthermia‐induced seizures caused by an S cn1a mutation Reviewed

Iori Ohmori, Nozomi Kawakami, Sumei Liu, Haijiao Wang, Ikuko Miyazaki, Masato Asanuma, Hiroyuki Michiue, Hideki Matsui, Tomoji Mashimo, Mamoru Ouchida

Epilepsia 55 ( 10 ) 1558 - 1567 2014.10

Neuroprotective Effects of Metallothionein Against Rotenone-Induced Myenteric Neurodegeneration in Parkinsonian Mice Reviewed

Shinki Murakami, Ikuko Miyazaki, Norio Sogawa, Ko Miyoshi, Masato Asanuma

Neurotoxicity Research 26 ( 3 ) 285 - 298 2014.10

Striatal Astrocytes Act as a Reservoir for L-DOPA Reviewed

Masato Asanuma, Ikuko Miyazaki, Shinki Murakami, Francisco J. Diaz-Corrales, Norio Ogawa

PLoS ONE 9 ( 9 ) e106362 - e106362 2014.9

Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats Reviewed

Ayaka Miyake, Yoshihisa Kitamura, Ikuko Miyazaki, Masato Asanuma, Toshiaki Sendo

Pharmacology Biochemistry and Behavior 122 240 - 245 2014.7

Lack of Dopaminergic Inputs Elongates the Primary Cilia of Striatal Neurons Reviewed International journal

Ko Miyoshi, Kyosuke Kasahara, Shinki Murakami, Mika Takeshima, Natsuko Kumamoto, Asako Sato, Ikuko Miyazaki, Shinsuke Matsuzaki, Toshikuni Sasaoka, Taiichi Katayama, Masato Asanuma

PLoS ONE 9 ( 5 ) e97918 - e97918 2014.5

Protective Effects of Phytochemical Antioxidants Against Neurotoxin-Induced Degeneration of Dopaminergic Neurons Reviewed

Taizo Kita, Masato Asanuma, Ikuko Miyazaki, Mika Takeshima

Journal of Pharmacological Sciences 124 ( 3 ) 313 - 319 2014.3

Effects of Bupropion and Pramipexole on Cell Proliferation in the Hippocampus of Adrenocorticotropic Hormone-Treated Rats Reviewed

Yuka Onoue, Keiko Kuwatsuka, Ikuko Miyazaki, Masato Asanuma, Yoshihisa Kitamura, Toshiaki Sendo

Biological & Pharmaceutical Bulletin 37 ( 2 ) 327 - 330 2014.2

Metallothionein deficiency exacerbates diabetic nephropathy in streptozotocin-induced diabetic mice Reviewed

Hiromi Tachibana, Daisuke Ogawa, Norio Sogawa, Masato Asanuma, Ikuko Miyazaki, Naoto Terami, Takashi Hatanaka, Chikage Sato Horiguchi, Atsuko Nakatsuka, Jun Eguchi, Jun Wada, Hiroshi Yamada, Kohji Takei, Hirofumi Makino

American Journal of Physiology-Renal Physiology 306 ( 1 ) F105 - F115 2014.1

Language：English Publishing type：Research paper (scientific journal) Publisher：American Physiological Society

Oxidative stress and inflammation play important roles in diabetic complications, including diabetic nephropathy. Metallothionein (MT) is induced in proximal tubular epithelial cells as an antioxidant in the diabetic kidney; however, the role of MT in renal function remains unclear. We therefore investigated whether MT deficiency accelerates diabetic nephropathy through oxidative stress and inflammation. Diabetes was induced by streptozotocin injection in MT-deficient (MT^−/−) and MT^+/+ mice. Urinary albumin excretion, histological changes, markers for reactive oxygen species (ROS), and kidney inflammation were measured. Murine proximal tubular epithelial (mProx24) cells were used to further elucidate the role of MT under high-glucose conditions. Parameters of diabetic nephropathy and markers of ROS and inflammation were accelerated in diabetic MT^−/− mice compared with diabetic MT^+/+ mice, despite equivalent levels of hyperglycemia. MT deficiency accelerated interstitial fibrosis and macrophage infiltration into the interstitium in the diabetic kidney. Electron microscopy revealed abnormal mitochondrial morphology in proximal tubular epithelial cells in diabetic MT^−/− mice. In vitro studies demonstrated that knockdown of MT by small interfering RNA enhanced mitochondrial ROS generation and inflammation-related gene expression in mProx24 cells cultured under high-glucose conditions. The results of this study suggest that MT may play a key role in protecting the kidney against high glucose-induced ROS and subsequent inflammation in diabetic nephropathy.

DOI： 10.1152/ajprenal.00034.2013

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アストロサイトによる神経機能修飾とパーキンソン病での神経保護 Invited

浅沼幹人

岡山医学会雑誌 126 ( 3 ) 203 - 208 2014

Cytoprotective effects of theanine contributed to the umami taste of green tea on cultured astroglial cells

10 ( 10 ) 179 - 191 2013.12

Targeting 5-HT1A receptors in astrocytes to protect dopaminergic neurons in parkinsonian models Reviewed

Ikuko Miyazaki, Masato Asanuma, Shinki Murakami, Mika Takeshima, Nao Torigoe, Yoshihisa Kitamura, Ko Miyoshi

Neurobiology of Disease 59 244 - 256 2013.11

Transplantation of Melanocytes Obtained from the Skin Ameliorates Apomorphine-Induced Abnormal Behavior in Rodent Hemi-Parkinsonian Models Reviewed

Masato Asanuma, Ikuko Miyazaki, Francisco J. Diaz-Corrales, Youichirou Higashi, Masayoshi Namba, Norio Ogawa

PLoS ONE 8 ( 6 ) e65983 - e65983 2013.6

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