Faculty Profiles - ASANUMA Masato

Papers - ASANUMA Masato

Division display 281 - 300 of about 318 ／ All the affair displays >>

脳梗塞後遺症における脳循環改善薬の有効症状スペクトラムの比較

小川紀雄, 浅沼幹人, 平田洋, 近藤洋一

Prog. Med. 12 ( 6 ) 1337 - 1344 1992.6

Haruhiko Takayama, Norio Ogawa, Mitsutoshi Yamamoto, Masato Asanuma, Hiroshi Hirata, Zensuke Ota

Clinical Chemistry and Laboratory Medicine 30 ( 5 ) 1992.5

Late onset and long-lasting suppressive effects of ceruletide, an analogue of cholecystokinin, on c-fos mRNA expression in the rat striatum Reviewed

Masato Asanuma, Norio Ogawa, Hiroshi Hirata, Kumiko Haba, Hsi-hsien Chou, Akitane Mori

Neuroscience Letters 138 ( 2 ) 233 - 236 1992.4

Effects of propentophylline on ischemia induced loss of muscarinic cholinergic receptor binding in the gerbil hippocampus Reviewed

Hiroshi Hirata, Norio Ogawa, Kumiko Haba, Masato Asanuma, Hsi-hsien Chou, Akitane Mori

Research Communications in Chemical Pathology and Pharmacology 75 ( 3 ) 365 - 368 1992.3

Language：English Publishing type：Research paper (scientific journal) Publisher：P J D PUBLICATIONS LTD

Super-delayed loss of muscarinic-1 (M1) receptors and the protective effect of propentofylline on these changes were examined in the gerbil hippocampus after transient ischemia with radioactive pirenzepine. M1 receptors were markedly decreased in the gerbil hippocampus 14 days after transient ischemia. Single administration of propentofylline (20mg/kg, ip) just after transient ischemia almost completely prevented the ischemia-induced decrease in the number of M1 receptors, and had no effect in sham-operated controls. These findings suggest that one of the therapeutic efficacies of propentofylline is the result of the normalization of the dysfunction of the acetylcholine neuronal system in cerebrovascular disease.

Web of Science

researchmap

多発性脳梗塞におけるnicergolineの臨床効果と¹²³I-IMP SPECT上の脳血流改善

小川紀雄, 浅沼幹人, 平田洋, 太田善介

臨床と研究 69 ( 3 ) 949 - 957 1992.3

Changes of neuropeptides and their receptors in experimental stroke gerbil brains Reviewed

Kumiko Haba, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yukiko H. Sora, Akitane Mori

Journal of the Neurological Sciences 108 ( 1 ) 88 - 92 1992.3

Development of a Simple Spasticity Quantification Method: Effects of Tizanidine on Spasticity in Patients with Sequelae of Cerebrovascular Disease Reviewed

Norio Ogawa, Masato Asanuma, Hiroshi Hiraata, Zensuke Ota, Yasuhide Yamawaki, Mitsutoshi Yamamoto

Journal of International Medical Research 20 ( 1 ) 78 - 86 1992.2

Publishing type：Research paper (scientific journal) Publisher：SAGE Publications

A simple method that can be performed at the bedside using a spring balance was developed in order to quantify spasticity. The effects of tizanidine on spasticity were evaluated in 30 patients with sequelae of cerebrovascular disease using this method. Treatment with tizanidine was effective in 60% of the patients; there were high correlations between spasticity before and after tizanidine administration and the severity of symptoms and also between the degree of improvement in spasticity and in that of the symptoms. Atonic seizures, due to overdose of tizanidine, were observed in only one patient. The simple spasticity quantification method developed was useful for monitoring tizanidine administration in order to prevent drug overdose. The method appears to be very useful for evaluating the degree of spasticity at the bedside and in measuring the effects of antispastic drugs.

DOI： 10.1177/030006059202000109

Web of Science

researchmap

Effects of chronic administration of lisuride hydrogen maleate on aromatic amine and metabolite levels in the gerbil brain following bilateral common carotid ligation Reviewed

Hiroshi Hirata, Norio Ogawa, Kumiko Haba, Masato Asanuma, Hsi-hsien Chou, Akitane Mori

Archives Internationales de Pharmacodynamie et de Therapie 315 ( 1-2 ) 5 - 15 1992.1

Language：English Publishing type：Research paper (scientific journal) Publisher：ARCH INT PHARMACODYNAMIE

Cerebral monoaminergic neurotransmitters and their metabolites show various concentration changes in gerbils following bilateral carotid ligation. The present study evaluated the effect of chronic administrations of lisuride hydrogen maleate (lisuride) on these changes. Lisuride (0.01 mg/kg or 0.05 mg/kg) or vehicle was intraperitoneally administered to gerbils for 14 consecutive days before the induction of a 30 min ischemia by bilateral carotid ligation. Animals were sacrified immediately and the levels of dopamine, DOPAC, homovanillic acid, noradrenaline, serotonin and 5-hydroxyindoleacetic acid determined by HPLC in the striatum, cortex, hippocampus and diencephalon/midbrain. Lisuride itself had no effect on any compound determined in any region. In the carotid-ligated gerbil brain, however, lisuride corrected the reduction of dopamine in the striatum, normalized or reduced increases in the (DOPAC + homovanillic acid)/dopamine ratio in the striatum, hippocampus and diencephalon/midbrain, and increased the levels of serotonin in all four regions. The present study, together with previous reports, indicate that lisuride may interfere with ischemia-induced cerebrovascular disturbances and, in such a way, improve some pathological sequelae of cerebrovascular disease.

Web of Science

researchmap

Chronic administration of lisuride hydrogen maleate increases muscarinic acetylcholine receptor binding in aged rat brain Reviewed

Haruhiko Takayama, Masato Asanuma, Kiminao Mizukawa, Hiroshi Hirata, Hirohiko Sato, Zensuke Ota, Norio Ogawa

Japanese Journal of Geriatrics 29 ( 1 ) 24 - 28 1992.1

Language：Japanese Publishing type：Research paper (scientific journal)

Changes in the distribution and densities of muscarinic acetylcholine receptors (mACh-R) in young adult and aged rat brain, and the effects of chronic administration of lisuride hydrogen maleate (lisuride) on these changes were studied by in vitro quantitative autoradiography of [3H] quinuclidinyl benzilate binding. mACh-R was relatively higher in the striatum, hippocampus and cerebral cortex in the young adult rats. In contrast, mACh-R binding was markedly reduced in the striatum, accumbens nucleus, amygdaloid nucleus and frontal cerebral cortex of aged rats compared to young adult rats. However, chronic administration of lisuride significantly increased mACh-R binding in the parietal cerebral cortex of aged rats compared to young adult rats. However, chronic administration of lisuride significantly increased mACh-R binding in the parietal cerebral cortex as well as in the above-mentioned regions in aged rats. This lisuride-induced increase in mACh-R of aged rat brain is considered to have important implications concerning the mechanism of therapeutic efficacy of lisuride.

DOI： 10.3143/geriatrics.29.24

Scopus

PubMed

researchmap

超高齢者の脳血管障害後遺症に対する脳代謝改善薬の有効症状のプロフィールの相違

浅沼幹人, 平田洋, 高山晴彦, 更井哲夫, 小川紀雄

臨床と研究 69 ( 1 ) 265 - 275 1992.1

Effects of bifemelane hydrochloride on loss of N-methyl-D-aspartate receptor and muscarinic cholinergic receptor binding in the gerbil hippocampus after transient ischemia Reviewed

Masato Asanuma, Norio Ogawa, Kumiko Haba, Hiroshi Hirata, Hsi-hsien Chou, Akitane Mori

Archives Internationales de Pharmacodynamie et de Therapie 315 ( 1-2 ) 16 - 21 1992.1

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：ARCH INT PHARMACODYNAMIE

The effects of bifemelane hydrochloride on changes of N-methyl-D-aspartate receptors and muscarinic cholinergic receptors were examined in the gerbil hippocampus after transient ischemia with radioactive-specific ligands. There were marked reductions in both these receptors in the gerbil hippocampus 14 days after transient ischemia, without changes in the respective affinities. Post-ischemia bifemelane treatment almost completely prevented the ischemia-induced decreases in the numbers of these receptors, and had no effect in sham-operated controls. The results of the present study suggest that this drug prevents postsynaptic dysfunction induced by transient ischemia, and may be useful in the therapy of both the chronic and the acute stage of cerebrovascular disease.

Web of Science

researchmap

Distinction between declarative memory and procedural memory using 8-arm radial maze task : Biphasic effects of thyrotropin reloading hormone on scopolamine-induced amnesia. Reviewed

Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Hsi-hsien Chou, Yoichi Kondo, Setsuko Ogawa, Akitane Mori

Research Communications in Psysiology, Psychiatry and Behavior 17 ( 1-2 ) 1 - 15 1992

Influence of protein-restricted diet on motor response fluctuations in Parkinson's disease

H. Hirata, M. Asanuma, Y. Kondo, N. Ogawa

Clinical Neurology 32 ( 9 ) 973 - 978 1992

Language：Japanese Publishing type：Research paper (scientific journal)

The clinical management of Parkinson's disease has been revolutionized by the introduction of levodopa therapy. It has significantly reduced disability and has extended life expectancies of patients with Parkinson's disease. However, motor response fluctuations frequently appear in patients after long-term treatment with levodopa. In this study, we investigated the effect of protein-restricted diet on fluctuations in eight patients with Parkinson's disease who had been receiving long-term levodopa treatment (mean 12.5 yrears). Two weeks of protein-restricted daytime diet (7.5 g total at breakfast and lunch) was followed by 12.5 g total at breakfast and lunch. At night, high-protein diet (40-50 g at dinner) was offered to the patients in order to maintain total daily protein intake at Japanese standard level. The medication schedule of levodopa and other antiparkinsonian drugs was not changed within 2 weeks after the study was began. Fluctuations were reduced in 7 of the 8 patients. But in only one patient (case 6), dyskinesia and general condition got worse and stopped this therapy. Body weight, serum protein and albumin levels did not change significantly for at least three months after the study was begun in every 6 patients who were examined. Homovanillic acid level of cerebrospinal fluid reduced in every 4 patients who were examined. We concluded that protein-restricted diet during the daytime offers a fascinating technique for the control of motor response fluctuations in patients with Parkinson's undergoing long-term levodopa treatment. But this therapy must be indicated carefully. Mechanism of this therapy may has something to do with improvement of dopamine metabolism in the brain.

Scopus

PubMed

researchmap

Distribution of the beta-2 adrenergic receptor messenger RNA in the rat brain by in situ hybridization histochemistry: Effects of chronic reserpine treatment Reviewed

Masato Asanuma, Norio Ogawa, Kiminao Mizukawa, Kumiko Haba, Hiroshi Hirata, Akitane Mori

Neurochemical Research 16 ( 12 ) 1253 - 1256 1991.12

Authorship：Lead author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

DOI： 10.1007/bf00966654

Web of Science

researchmap

Other Link： http://link.springer.com/article/10.1007/BF00966654/fulltext.html

Calcium antagonist flunarizine hydrochloride affects striatal D2 dopamine receptors in the young adult and aged rat brain Reviewed

Masato Asanuma, Norio Ogawa, Kumiko Haba, Hiroshi Hirata, Akitane Mori

Archives of Gerontology and Geriatrics 13 ( 3 ) 271 - 278 1991.11

ソマトスタチン減少剤 Invited

浅沼幹人, 小川紀雄

生体の科学 42 ( 5 ) 505 - 506 1991.10

Effects of beta-adrenergic blocking agents on specific binding of [3H]D-Ala2-Met5-enkephalinamide and [3H]naloxone. Reviewed

Haruhiko Takayama, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Toshio Ogura, Zensuke Ota

Acta Medica Okayama 45 ( 5 ) 295 - 299 1991.10

Dopamine deficiency in the Weaver mutant mouse: An animal model of olivopontocerebeller atrophy Reviewed

Hsi-hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Akitane Mori

Research Communications in Chemical Pathology and Pharmacology 74 ( 1 ) 117 - 120 1991.10

Language：English Publishing type：Research paper (scientific journal) Publisher：P J D PUBLICATIONS LTD

The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied. Dopamine levels of 6-week-old weaver mice were 37%, 44%, 34%, and 41% of levels in age-matched controls in the cerebral cortex, hippocampus, septal region and striatum, respectively. Noradrenaline levels did not differ from controls. This study shows that weaver mice have specific deficiencies in the dopamine system.

Web of Science

researchmap

Long-lasting effect of ceruletide on dyskinesia and monoaminergic neuronal pathways in rats treated with iminodipropionitrile Reviewed

Norio Ogawa, Kumiko Haba, Masato Asanuma, Akitane Mori

Brain Research 556 ( 2 ) 271 - 279 1991.8

神経伝達物質とパーキンソン病 Invited

浅沼幹人, 小川紀雄

臨床成人病 21 ( 7 ) 1191 - 1199 1991.7

　 PREV - NEXT 　

< ASANUMA Masato >

Papers - ASANUMA Masato