Faculty Profiles - OTSUKA Fumio

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Renal AT(1) receptor: Computerized quantification in spontaneously hypertensive rats and DOCA-salt rats

N Asano, T Ogura, Y Mimura, F Otsuka, M Kishida, M Hashimoto, T Yamauchi, H Makino

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 100 ( 2 ) 171 - 180 1998.5

Language：English Publisher：P J D PUBLICATIONS LTD

To assess the involvement of angiotensin II (Ang II) in the regulation of blood pressure, we investigated the alterations of renal Ang II type 1 (AT(1)) receptors in two different models of hypertension; i.e., in spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)-salt hypertensive rats by using the method for quantification of in vitro macroautoradiography (ARG). In the SHR model, although the number of cortical AT(1) receptors equaled that of Wistar Kyoto (WKY) rats at 4 and 12 weeks of age, the number of medullary AT(1) receptors in the 4-week-old SHR animals was significantly lower than that in age-matched WKY rats, and increased by 12 weeks of age. The renal AT(1) receptor number in DOCA-salt hypertensive rats was significantly higher than that in control rats. The amount of these receptors also increased with age in both DOCA-salt hypertensive rats and control rats. These findings indicate that the development of medullary AT(1) receptors in early stages of hypertension in the SHR model differs from that in WKY rats or DOCA-salt hypertensive rats. This suggests that renal AT(1) receptors may contribute to the hypertension seen in the SHR group. The renal AT(1) receptors appear to be up-regulated in early stages of DOCA-salt-induced hypertension as well.

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Renal AT(1) receptor: Autoradiographic localization and quantification in rat

N Asano, T Ogura, Y Mimura, M Kishida, H Kataoka, F Otsuka, T Yamauchi, H Makino

RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY 100 ( 2 ) 161 - 170 1998.5

Language：English Publisher：P J D PUBLICATIONS LTD

To elucidate the precise localization of angiotensin II (Ang II) type 1 (AT(1)) receptor in the kidney, we utilized in vitro macro- and micro-autoradiography (ARG) of [H-3]-Ang II bindings to the Wistar rat kidney in the presence of L158,809, a specific non-peptide AT(1) receptor antagonist. Besides, we estimated the density of renal AT, receptors using the quantification of macro-ARG. The density of [H-3]-Ang II binding to renal tissue was concentration-dependent in both renal cortex and medulla Although the addition with 500 nM arginine vasopressin and 500 nM atrial natriuretic peptide had no effect on [H-3]-Ang II, the total binding of [H-3] Ang II completely displaced by the addition with 500 nM unlabeled Ang II or L-158,809. Macro-ARG revealed that the amount of both Ang II and AT, receptors in the renal medulla gready exceeded those in the renal cortex In the medulla, the density of these receptors was not localized on the outer medulla but was confirmed mainly to the inner medulla, especially to the inner zone and longitudinal bands. Since the density and localization of AT(1) receptors was consistent with that of total Ang II receptors, it appears that AT(1) receptors comprise most of the Ang II receptors in the kidney. Micro-ARG revealed that Ang II receptors were mainly located in the glomerulus and proximal tubules of the renal cortex, as well as on the circumferences of vessels and the vasa recta of the renal medulla. The present study established a method for ARO of AT(1) receptors in the kidney as well as a method for quantifying the macro-ARG.

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Sheehan syndrome : Dictionary of syndromes

Shindan To Chiryo suppl 85 484 1998

The effects of intrinsic vasopressin on urinary aquaporin-2 excretion and urine osmolality during the operation under general anesth・・・

Fumio Otsuka, Kiyoshi Morita, Mamoru Takeuchi, Takayoshi Yamauchi, Toshio Ogura, Masahisa Hirakawa and Hirofumi Makino:

Anesth. Analg. 88 181 - 187 1998

Painless thyroiditis during glucocorticoid replacement therapy after pituitary adenomectomy in an old man.

Yukari Mimura, Nobuhiko Hayakawa, Fumio Otsuka, Masayuki Kishida, Takayoshi Yamauchi, Hirofumi Makino, Toshio Ogura and Takashi Tamiya :

Clin. Endocrinol. 46 219 - 224 1998

下垂体腺腫摘出後のステロイド補償療法中に発症した高齢男性の無痛性甲状腺炎の１例

三村由香里, 早川信彦, 大塚文男, 岸田雅之, 山内崇義, 槇野博史, 小倉俊郎, 田宮隆

ホルモンと臨床 1998

SLEにみられる肺病変

大塚文男, 小倉俊郎, 槇野博史

リウマチ科 18: 161-168 1997

胃への直接浸潤による消化管出血に対しフィブリノゲン加第XIII因子が有効であった肺腺癌の１例

宮武伸行, 早川信彦, 上野明子, 丸山啓輔, 河島昌典, 大塚文男, 四方賢一, 小倉俊郎, 岡田裕之, 槇野博史

日本臨床内科医会会誌 1997

Insulin dependent diabetes mellitus accompanied by a growth hormone producing pituitary adenoma.

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Kenichi Shikata, Jingo Kageyama, Hirofumi Makino

Diabetes Care 1997

Insulin dependent diabetes mellitus accompanied by a growth hormone producing pituitary adenoma

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Kenichi Shikata, Jingo Kageyama and Hirofumi Makino:

Diabetes Care 20 1838 - 1841 1997

Deep vein thrombosis : A case of deep vein thrombosis probably due to specific disorder of coagulation system. In

Keiji Yunoki, Kotaro Suehiro, Hatsuzo Uchida, Shunji Sano, Fumio Otsuka, Tetsuki Amano, Hirofumi Makino, Zensuke Ota

Diseases of vein and lymph duct and surgery, Axel Springer Japan Publishing Inc., Tokyo 65 - 67 1997

SLEの肺病変

Rheumatology 18 161 - 168 1997

Adenocarcinoma of the lung with stomach bleeding secondary to direct invasion succ・・・

Nobuyuki Miyatake, Hayakawa Nobuhiko, Akiko Ueno, Keisuke Maruyama, Masanori Kawashima, Fumio Otsuka, Kenichi Shikata, Toshio Ogura, Hiroyuki Okada and Hirofumi Makino :

J. Jap. Physic. Assoc. 12 151 - 154 1997

Insulin dependent diabetes mellitus accompanied by a growth hormone producing pituitary adenoma

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Kenichi Shikata, Jingo Kageyama and Hirofumi Makino:

Diabetes Care 20 1838 - 1841 1997

A case of deep vein thrombosis probably due to specific disorder of coagulation system. In

Keiji Yunoki, Kotaro Suehiro, Hatsuzo Uchida, Shunji Sano, Fumio Otsuka, Tetsuki Amano, Hirofumi Makino and Zensuke Ota : Deep vein thrombosis :

Diseases of vein and lymph duct and surgery, Axel Springer Japan Publishing Inc., Tokyo 65 - 67 1997

DIABETES-INSIPIDUS WITH BEHCETS-DISEASE

F OTSUKA, T AMANO, T OGURA, Z OTA

LANCET 346 ( 8988 ) 1494 - 1495 1995.12

A case of thymoma with pure red cell aplasia and increased anti-acetylcholine receptor antibody

Takahiro Mukaida, Hiroshi Date, Motoi Aoe, Akio Andou, Nobuyoshi Shimizu, Yoshiko Hayashi, Fumio Otsuka, Shuji Ikeda and Toshio Ogura:

Nippon Kyobu Rinsho 54 875 - 861 1995

抗アセチルコリンレセプター抗体高値を呈した赤芽球癆合併胸腺腫の１例

向田尊洋, 伊達洋至, 青江基, 安藤陽夫, 清水信義, 林佳子, 大塚文男, 池田修二, 小倉俊郎

日本胸部臨床 1995

Effect of APD system on QOL of patients and their family

Fumio Otsuka, Kenta Fujiwara, Tetsuya Ono, Masao Kaji, Ayako Hirano, Tomoko Ichiraku, Mihoko Chiba, Miyako Naruto

Chugoku J. Renal Failure 2 96 - 97 1993

Peritonitis in patients with APD system

Kenta Fujiwara, Fumio Otsuka, Tetsuya Ono, Masao Kaji, Ayako Hirano, Tomoko Ichiraku, Mihoko Chiba, Miyako Naruto

Chugoku J. Renal Failure 2 114 - 145 1993

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