Faculty Profiles - OTSUKA Fumio

MISC - OTSUKA Fumio

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A case manifesting systemic lupus erythematosus during the a・・・

Hiroo Hashimoto, Fumio Otsuka, Hiroko Yamasaki, Toru Okamoto, Tetsushi Aita, Norikuni Kawanaka, Masanaori Kawashima, Yoshitaka Morita, Naoki Kashihara, Masahiro Yamanura and Hirofumi Makino :

Clin. Rheumatol. 12 45 - 52 2000

Over-Expression of IGF-Ⅱ and PCNA mRNA in an ACTH-Producing pituitary adenoma showing rapid growth seven year・・・

Toshihiro Takao, Mari Inoue, Koichi Asaba, Isao Nagano, Wakako Nanamiya, Masahiro Kurisaka, Fumio Otsuka, Hirofumi Makino and Kozo Hashimoto :

Jpn. J. Endocrinol. 76(Suppl.) 14 - 16 2000

Quantitative analysis of growth-related factors in human pituitary adenomas - Lowered insulin-like growth factor-I and its receptor mRNA in growth hormone-producing adenomas

F Otsuka, T Tamiya, T Yamauchi, T Ogura, T Ohmoto, H Makino

REGULATORY PEPTIDES 83 ( 1 ) 31 - 38 1999.8

Language：English Publisher：ELSEVIER SCIENCE BV

To elucidate the contribution of growth factors to the development, growth and behavior of human pituitary adenomas, the authors used competitive reverse transcription-polymerase chain reactions to quantify expression of mRNAs for growth factors extracted from pituitary adenomas. As previously diagnosed by endocrinologic evaluation, the pituitary adenomas in this study consisted of six prolactin-producing, six growth hormone (GH)-producing, four follicle-stimulating hormone producing and six nonfunctioning adenomas. The mRNAs examined included those for platelet-derived growth factor (PDGF) B-chain, transforming growth factor (TGF)-beta 1, epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor (IGF)-I and -II; proliferating cell nuclear antigen (PCNA) as an indicator of cell proliferation; and pituitary-specific transcription factor-1 (Pit-1) which is a nuclear transcription factor expressed in the anterior pituitary. All factors except the last were expressed in all adenomas, and expression of PDGF B-chain, TGF-beta 1, EGF, bFGF and IGF-II did not differ between the four adenoma varieties. Pit-1 was expressed only in GH- and prolactin-producing adenomas. PCNA expression also showed no differences. However, IGF-I mRNA in GH-producing adenomas was significantly lower than in prolactin-producing and nonfunctioning adenomas despite high serum IGF-I levels (1121+/-253 ng/ml), The analysis on IGF-I receptor mRNA was significantly lowered in GH-producing adenoma compared with the other types of adenoma, These findings suggest that the attenuation of negative feedback through the pituitary GH-IGF-I axis may be involved in development of GH-producing adenoma. (C) 1999 Elsevier Science B.V. All rights reserved.

DOI： 10.1016/S0167-0115(99)00048-8

全身麻酔下手術での内因性バゾプレッシン上昇が尿中AQP2排泄及び尿濃縮能へ与える影響

小倉俊郎, 大塚文男, 山内崇義, 片岡秀雄, 三村由香里, 高橋雅己, 岸田雅之, 関根恭一, 三浦雅一, 槇野博史

日本内分泌学会雑誌 75 ( 1 ) 120 - 120 1999.4

Addison''s disease : Adrenocortical disorders. In : H. Imura (Ed.)

Fumio Otsuka, Jingo Kageyama

Wakariyasui Naikagaku, Bunkodo Preess, Tokyo 679 - 683 1999

ACTHによるラット副腎皮質肥大への成長因子の関与

大塚文男, 小倉俊郎, 山内崇義, 三村由香里, 片岡秀雄, 高橋雅己, 岸田雅之, 槇野博史

ACTH Related Peptides 1999

高血圧ラットにおける腎c-fosの発現とその抑制

大塚文男, 小倉俊郎, 山内崇義, 槇野博史

Therapeuric Research 1999

Contribution of growth factors to adrenal hypertrophy in rats.

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Yukari Mimura, Hideo Kataoka, Masami Takahashi, Masayuki Kishida, Hirofumi Makino

ACTH Related Peptides 10 47 - 54 1999

レニン・アンジオテンシン心血管フォーラム

Medical Tribune Oct 21 21 - 24 1999

わかりやすい内科学

わかりやすい内科学 696 - 700 1999

The change of C-Fos expression in hypertensive rats.

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Hirofumi Makino

Therapeutic Research 20 47 - 54 1999

Addison''s disease : Adrenocortical disorders. In : H. Imura (Ed.)

Fumio Otsuka, Jingo Kageyama

Wakariyasui Naikagaku, Bunkodo Preess, Tokyo 679 - 683 1999

Fumio Otsuka, Renin-Angiotensin system and cardiovascular forum : Panel discussion

Medical Tribune Oct 21 21 - 24 1999

Contribution of growth factors to adrenal hypertrophy in rats.

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Yukari Mimura, Hideo Kataoka, Masami Takahashi, Masayuki Kishida and Hirofumi Makino :

ACTH Related Peptides 10 47 - 54 1999

Adrenal disorders

Wakariyasui Naikagaku, Bunkodo Press, Tokyo 696 - 700 1999

The change of C-Fos expression in hypertensive rats.

Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi and Hirofumi Makino :

Therapeutic Research 20 47 - 54 1999

Effect of treatment with barnidipine, a calcium channel blocker, on platelet-derived growth factor B chain from glomerulus in spontaneously hypertensive rats.

Hashimoto M, Yamauchi T, Ogura T, Oishi T, Mimura Y, Otsuka F, Kashihara N, Makino H

Am J Nephrol 1999

Cluster headache dependent upon octreotide injection

F Otsuka, J Kageyama, T Ogura, H Makino

HEADACHE 38 ( 8 ) 629 - 629 1998.9

Sheehan's syndrome of more than 30 years' duration: an endocrine and MRI study of 6 cases

F Otsuka, J Kageyama, T Ogura, T Hattori, H Makino

ENDOCRINE JOURNAL 45 ( 4 ) 451 - 458 1998.8

Language：English Publisher：JAPAN ENDOCRINE SOCIETY

The endocrine function and pituitary imaging in Sheehan's syndrome more than 30 years after causative events were evaluated. Magnetic resonance imaging (MRI), a combined anterior pituitary test, plasma vasopressin-to-osmolality adaptation study, and antithyroid and antipituitary cell antibody measurement were performed in 6 women with Sheehan's syndrome. The interval from delivery to the onset of symptoms of hormonal deficiency ranged from 3 to 32 years. Since clinical onset, all had received glucocorticoid and thyroid replacement therapy. Cranial MRI examination showed an "empty sella" in 5 cases. Among these, 2 of 5 (40%) demonstrated panhypopituitarism and the other 3 (60%) maintained gonadotropin response. The pituitary gland was normally discernible but with a low-intensity lesion on T1-weighted images in a patient who maintained PRL and gonadotropin responses. Posterior pituitary function was abnormal in 3 of 6 (50%) despite the absence of polyuria. No antipituitary antibodies were detected in any of the cases. Thyroid peroxidase antibody was negative in all cases, but antithyroglobulin antibody was detected in 2 of 6 (33%). Thyroid-stimulating antibody was not detected, but one case had an anti-TSH antibody. Thirty years after the initial events, most patients with Sheehan's syndrome showed signs of an empty sella on MRI, all having noticeable suppression of anterior and/or posterior pituitary hormones with no related autoimmunity.

DOI： 10.1507/endocrj.45.451

Effects of chronic inhibition of ACE and AT(1) receptors on glomerular injury in Dahl salt-sensitive rats

F Otsuka, T Yamauchi, H Kataoka, Y Mimura, T Ogura, H Makino

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 274 ( 6 ) R1797 - R1806 1998.6

Language：English Publisher：AMER PHYSIOLOGICAL SOC

To elucidate the contribution of the renin-angiontensin system (RAS) to glomerular injury in salt-sensitive hypertension, we investigated the chronic effects of the angiotensin I-converting enzyme inhibitor cilazapril and the angiotensin II type 1-receptor antagonist (AT(1a)) TCV-116 in Dahl-Iwai rats. Dahl salt-sensitive (S) rats receiving 8% salt diet for 6 wk were simultaneously treated with cilazapril (n = 6), TCV-116 (n = 6), or saline (n = 14). The 8% salt diet markedly increased systolic blood pressure (SBP), urinary protein, and N-acetyl-beta-glucosaminidase (NAG) excretion compared with 0.3% salt-treated 8 (n = 6) or salt-resistant (n = 6) rats. Although neither cilazapril nor TCV-116 reduced the elevated SEP, TCV-116 significantly lowered urinary protein and NAG excretion. Histologically, 8% salt treatment in 8 rats induced progressive sclerotic and proliferative glomerular changes, which were ameliorated by both drugs. TCV-116 increased the glomerular diameter. Immunofluorescence demonstrated the increased level of type III collagen in the mesangium of 8% salt-treated 8 rats, which was completely reversed by TCV-116. Competitive RT-PCR of mRNA extracted from the glomeruli revealed that 8% salt treatment significantly increased the levels of proliferating cell nuclear antigen (PCNA) and platelet-derived growth factor B-chain and that TCV-116 significantly reduced the levels of PCNA and transforming growth factor-beta 1 (TGF-beta 1). Thus, although the chronic RAS-inhibition in salt-sensitive hypertension exerted a histologically renoprotective effect by both ways without lowering blood pressure, the RAS inhibition due to AT(1a) had more beneficial advantages of reducing proteinuria and attenuating the levels of glomerular TGF-beta 1 and extracellular matrix.

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