Faculty Profiles - OTSUKA Fumio

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重度の吸収障害でLT4投与法に苦慮した甲状腺機能低下症の1例

越智可奈子, 大塚文男, 中村絵里, 塚本尚子, 武田昌也, 稲垣兼一, 三好智子, 三村由香里, 小倉俊郎, 名和秀起, 槇野博史

日本内分泌学会雑誌 87 ( 3 ) 2011

慢性イレウス・吸収不良により経口T₄製剤不応性の甲状腺機能低下症の1例

越智可奈子, 大塚文男, 中村絵里, 塚本尚子, 武田昌也, 稲垣兼一, 三好智子, 三村由香里, 小倉俊郎, 名和秀起, 槇野博史

日本内分泌学会雑誌 87 ( 2 ) 2011

妊娠・出産の経過中に検出されたマクロプロラクチン血症の一例

塚本尚子, 大塚文男, 服部尚樹, 鎌田泰彦, 越智可奈子, 中村絵里, 武田昌也, 三好智子, 稲垣兼一, 三村由香里, 小倉俊郎, 槇野博史

日本内分泌学会雑誌 87 ( 3 ) 2011

35年前の外傷による視床下部・下垂体機能低下症と診断した一例

稲垣兼一, 山成俊夫, 難波早耶香, 越智可奈子, 中村絵里, 塚本尚子, 武田昌也, 三好智子, 大塚文男, 三村由香里, 槇野博史

日本内分泌学会雑誌 87 ( 3 ) 2011

膠原病と副腎性クッシング症候群を併発した2症例

武田昌也, 大塚文男, 稲垣兼一, 三好智子, 塚本尚子, 中村絵里, 越智可奈子, 小倉俊郎, 景山甚郷, 槇野博史

日本内分泌学会雑誌 87 ( 3 ) 2011

内分泌調節のキーファクターBMP —その生理活性メカニズムの解明と生殖医療への応用—

大塚文男

両備檉園記念財団研究助成報告・生物学に関する試験論叢 26 2011

同時摘出した副甲状腺機能亢進症とパラガングリオーマの合併例

安田麻衣子, 稲垣兼一, 大塚文男, 小倉可奈子, 武田昌也, 塚本尚子, 中村絵里, 三好智子, 鈴木二郎, 三村由香里, 小倉俊郎, 槇野博史

日本内分泌学会雑誌 86 ( 3 ) 745 - 745 2010.12

副腎プレクリニカルクッシング症候群による若年性高血圧の1例

小倉可奈子, 大塚文男, 中村絵里, 塚本尚子, 武田昌也, 稲垣兼一, 三好智子, 鈴木二郎, 三村由香里, 小倉俊郎

日本内分泌学会雑誌 86 ( 3 ) 734 - 734 2010.12

尿崩症を伴い生検にて診断したリンパ球性下垂体炎の若年男性例

小倉可奈子, 大塚文男, 武田昌也, 中村絵里, 塚本尚子, 稲垣兼一, 三好智子, 鈴木二郎, 小倉俊郎, 小野成紀, 橋本昌美, 槇野博史

日本内分泌学会雑誌 86 ( 3 ) 680 - 680 2010.12

抗甲状腺薬により劇症肝炎をきたし肝移植にて救命しえた一例

塚本尚子, 大塚文男, 鈴木二郎, 武田昌也, 稲垣兼一, 小倉可奈子, 中村絵里, 三好智子, 三村由香里, 小倉俊郎, 元木崇之, 槇野博史

日本内分泌学会雑誌 86 ( 3 ) 671 - 671 2010.12

生体部分肝移植により救命しえたpropylthiouracilによる劇症肝炎の一例

鈴木二郎, 大塚文男, 武田昌也, 稲垣兼一, 塚本尚子, 小倉可奈子, 三村由香里, 小倉俊郎, 元木崇之, 松岡順治, 槇野博史

日本内分泌学会雑誌 86 ( 2 ) 294 - 294 2010.9

Functional relationship between fibroblast growth factor-8 and bone morphogenetic proteins in regulating steroidogenesis by rat granulosa cells. International journal

Tomoko Miyoshi, Fumio Otsuka, Misuzu Yamashita, Kenichi Inagaki, Eri Nakamura, Naoko Tsukamoto, Masaya Takeda, Jiro Suzuki, Hirofumi Makino

Molecular and cellular endocrinology 325 ( 1-2 ) 84 - 92 2010.8

Language：English Publisher：ELSEVIER IRELAND LTD

Bone morphogenetic proteins (BMPs) have been recognized as crucial molecules in regulating ovarian physiology, with different BMPs having differential actions in FSH-induced estradiol production. To identify the roles of oocyte factors that modulate steroidogenesis controlled by BMPs, we here investigated the effects of FGF-8 in rat granulosa/oocyte co-cultures. FGF-8 potently suppressed FSH-induced estradiol production, but did not affect cAMP-induced estradiol produced by rat granulosa cells. FGF-8 had no effects on progesterone and cAMP production induced by FSH and forskolin. The inhibitory effects of FGF-8 on FSH-induced estradiol production were not altered by BMP-2, -4, -6 or -7. In the presence of FGF-8, BMPs suppressed FSH-induced progesterone by reducing cAMP, suggesting that FGF-8 and BMP independently regulate FSH receptor signaling. Notably, FGF-8-induced ERK and SAPK/JNK phosphorylation in granulosa cells, in which ERK activation was further enhanced by FSH and oocytes. Inhibition of ERK and SAPK/JNK reduced FSH-induced progesterone and cAMP levels, suggesting that the activation of these pathways enhances FSH-induced cAMP signaling. In addition, ERK inhibition upregulated FSH-induced estradiol synthesis, indicating that ERK pathway is also involved in suppressing aromatase activity in granulosa cells. Interestingly, FGF-8 enhanced BMP-induced Smad1/5/8 and Id-1-promoter activities with decreased expression of Smad6/7. Since the SAPK/JNK inhibitor inhibited FGF-8 effects in upregulating Id-1 transcription, SAPK/JNK appears to be involved in the mechanism by which FGF-8 enhances BMP-Smad signaling. Furthermore, in the presence of oocytes, the inhibition of endogenous FGF receptor signaling suppressed FSH- and forskolin-induced progesterone and cAMP, showing that endogenous FGF system is involved in activation of FSH-induced cAMP-PKA signaling via ERK and SAPK/JNK. Thus, the oocyte factor, FGF-8, not only suppresses FSH-induced estradiol production by activating ERK, but also enhances BMP-Smad signaling in granulosa cells. This interaction between FGF-8 and BMPs may play a key role in regulating steroidogenesis through oocyte-granulosa cell communication. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.mce.2010.04.012

The 2008 Okayama Medical Association Awards: Aldosterone breakthrough caused by chronic blockage of angiotensin 2 type 1 receptors in human adrenocortical cells: possible involvement of bone morphogenetic protein-6 actions

Journal of Okayama Medical Association 122 ( 1 ) 27 - 31 2010.4

Effects of steroids on functional interaction between TNF-alpha and BMP-2 in osteoblast differentiation

Yoshinori Matsumoto, Fumio Otsuka, Tomoyuki Mukai, Mariko Takano, Ryutaro Yamanaka, Misuzu Yamashita, Masaya Suzuki, Jiro Suzuki, Tomoko Miyoshi, Kenichi Inagaki, Hirofumi Makino

ENDOCRINE JOURNAL 57 S499 - S499 2010.3

Regulation of FSH transcription by GnRH and BMP in pituitary gonadotrope L beta T2 cells

Masaya Takeda, Fumio Otsuka, Hiroaki Takahashi, Kenichi Inagaki, Tomoko Miyoshi, Naoko Tsukamoto, Hiroyuki Otani, Eri Nakamura, Mark A. Lawson, Hirofumi Makino

ENDOCRINE JOURNAL 57 S516 - S516 2010.3

Effects of fibroblast growth factor (FGF)-8 on ovarian steroidogenesis: involvement of upregulation of BMP receptor singnaling

Tomoko Miyoshi, Fumio Otsuka, Misuzu Yamashita, Kenichi Inagaki, Jiro Suzuki, Eri Nakamura, Naoko Tsukamoto, Masaya Takeda, Yukari Mimura, Toshio Ogura, Hirofumi Makino

ENDOCRINE JOURNAL 57 S613 - S614 2010.3

卵母細胞因子FGF-8とBMPによる新たな卵胞ステロイド分泌調節の検討.

三好智子, 大塚文男

日本生殖内分泌学会雑誌 15 47 - 51 2010

BMPによる卵胞刺激.

稲垣兼一, 大塚文男

産科と婦人科 77 ( 3 ) 317 - 322 2010

高血圧に潜む原発性アルドステロン症 PACやPRAの測定による積極的スクリーニングを.

大塚文男

Medical Tribune 43 ( 12 ) 78 - 78 2010

それは、成長ホルモンが足りていない可能性があります.

大塚文男

山陽新聞 2010

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