研究者詳細 - 西田　圭一郎

論文 - 西田　圭一郎

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周術期の管理エタネルセプト使用症例の周術期感染頻度の検討

中原龍一, 西田圭一郎, 金澤智子, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 340 - 340 2010年10月

関節病に対する上肢人工関節置換術関節リウマチ肘関節破壊に対するJACE型人工肘関節置換術の中期成績

橋詰謙三, 西田圭一郎, 中原龍一, 斎藤太一, 金澤智子, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 409 - 409 2010年10月

橈骨遠位端掌側部の組織学的検討いわゆるWatershed Lineを中心に

今谷潤也, 清水弘毅, 高田逸朗, 西田圭一郎, 秋田恵一

日本手外科学会雑誌 26 ( 5 ) 466 - 468 2010年9月

三次元実体石膏模型を利用して治療した反復性肩関節脱臼の1例

井上円加, 中原龍一, 斎藤太一, 金澤智子, 島村安則, 小澤正嗣, 阿部信寛, 野田知之, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 176 - 176 2010年9月

鎖骨骨幹部骨折に対する前下方プレート法による治療成績

島村安則, 野田知之, 中原龍一, 金澤智子, 井上円加, 斎藤太一, 小澤正嗣, 雑賀建多, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 75 - 75 2010年9月

橈骨遠位端掌側ロッキングプレートにおける屈筋腱障害の発生要因解剖学的検討を基に

清水弘毅, 今谷潤也, 高田逸朗, 中道亮, 山川泰明, 大塚亮介, 岡田幸正, 井上円加, 川上幸雄, 林正典, 西田圭一郎

中国・四国整形外科学会雑誌 22 ( 2 ) 496 - 496 2010年9月

ヒト軟骨細胞様細胞においてADAMTS-5はRUNX-2を介してメカノセンシティブに機能するアグリカナーゼである

鉄永智紀, 西田圭一郎, 古松毅之, 斎藤太一, 成瀬恵治, 尾崎敏文

日本整形外科学会雑誌 84 ( 8 ) S1230 - S1230 2010年8月

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino

Arthritis Research and Therapy 12 ( 4 ) 637 - 639 2010年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA), and to examine whether there is a link between HDAC activity and synovial inflammation.Methods: HDAC activity and histone acetyltransferase (HAT) activity were determined in nuclear extracts of total synovial tissue surgically obtained from normal, OA and RA joints. The level of cytoplasmic tumor necrosis factor a (TNFα) fraction was measured by ELISA. Total RNA of synovial tissue was used for RT-PCR of HDAC1-8. In synovial fibroblasts from RA (RASFs), the effects of TNFα on nuclear HDAC activity and class I HDACs (1, 2, 3, 8) mRNA expressions were examined by quantitative real-time PCR. The protein expression and distribution of class I HDACs were examined by Western blotting.Results: Nuclear HDAC activity was significantly higher in RA than in OA and normal controls and correlated with the amount of cytoplasmic TNFα. The mRNA expression of HDAC1 in RA synovial tissue was higher than in OA and normal controls, and showed positive correlation with TNFα mRNA expression. The protein level of nuclear HDAC1 was higher in RA synovial tissue compared with OA synovial tissue. Stimulation with TNFα significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.Conclusions: Our results showed nuclear HDAC activity and expression of HDAC1 were significantly higher in RA than in OA synovial tissues, and they were upregulated by TNFα stimulation in RASFs. These data might provide important clues for the development of specific small molecule HDAC inhibitors. © 2010 Kawabata et al.
licensee BioMed Central Ltd.

DOI： 10.1186/ar3071

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Radiographic measurements in the evaluation and classification of elbow joint destruction in patients with rheumatoid arthritis

Kenzo Hashizume, Keiichiro Nishida, Kazuo Fujiwara, Yasutaka Kadota, Ryuichi Nakahara, Kazuhiko Ezawa, Hajime Inoue, Toshifumi Ozaki

CLINICAL RHEUMATOLOGY 29 ( 6 ) 637 - 643 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER LONDON LTD

We developed two new radiographic parameters-the humeral surface height ratio and ulnar surface height ratio-to precisely detect changes in the bony structure of rheumatoid elbows. Of the 59 patients with rheumatoid arthritis, 101 elbows were classified into four types (osteoarthritis, ankylosis, erosive, and resorptive) according to the radiographic appearance. Clinically, osteoarthritis type and ankylosis type were considered to be stable form, and erosive type and resorptive type were unstable form. Patients' clinical data and yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and ulnar surface height ratio were compared among the four types and between the two forms. There were significant differences between the two forms and among the three types except for the ankylosis type in yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and ulnar surface height ratio. Stable and unstable forms were distinguished by a cut-off point of 0.65 and 2.58 in yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and the ulnar surface height ratio, respectively. These parameters might be useful for monitoring the structural changes of the elbow joint in rheumatoid arthritis.

DOI： 10.1007/s10067-010-1381-y

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Preoperative Time Required for the Timed "Up and Go" Test in Women with Hip Osteoarthritis Could Predict a Deep Venous Thrombosis Complication after Total Hip Arthroplasty

Kentaro Sasaki, Masuo Senda, Keiichiro Nishida, Haruyuki Ota

ACTA MEDICA OKAYAMA 64 ( 3 ) 197 - 201 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We examined whether the preoperative time required for the Timed "Up and Go" (TUG) test could predict the risk for deep venous thrombosis (DVT) in patients with hip osteoarthritis after total hip arthroplasty (THA). Eighteen patients with DVT diagnosed by venography were selected, and 18 without DVT of the same age and sex and with the same operated side as the DVT group were selected as a control group. We evaluated the 5 preoperative factors that might affect the occurrence of DVT complications, as follows: disease duration, body mass index, serum total cholesterol, subjective pain evaluated by the visual analog scale, and TUG. The JOA hip score (pain, range of motion, walking ability, and daily life) was also evaluated before surgery. As a postoperative factor, we checked the postoperative day when weight-bearing was initiated. As a result, TUG (DVT, 18.4 +/- 4.0 sec vs. control, 15.0 +/- 3.2 sec; p < 0.01) was only significantly different between the 2 groups. The ROC curve revealed that the cut-off point of 15.3 sec in preoperative time for TUG was sensitive (83.3%) and specific (61.1%) for DVT after THA (odds ratio = 7.0; 95% confidence interval, 1.6-30.8). These results suggested that low preoperative ambulatory ability in patients with hip osteoarthritis might be associated with DVT after THA. An improvement in TUG before surgery might contribute to a decrease in the occurrence of DVT after THA.

DOI： 10.18926/AMO/40012

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The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito, Naoya Toriuchi, Teruhito Yoshitaka, Hiroe Ueno-Kudoh, Tempei Sato, Shigetoshi Yokoyama, Keiichiro Nishida, Takayuki Akimoto, Michiko Takahashi, Shigeru Miyaki, Hiroshi Asahara

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 ( 23 ) 10538 - 10542 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATL ACAD SCIENCES

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

DOI： 10.1073/pnas.1000525107

Biomechanical Evaluation of the Fixation Methods for Transcondylar Fracture of the Humerus: ONI Plate Versus Conventional Plates and Screws

Yasunori Shimamura, Keiichiro Nishida, Junya Imatani, Tomoyuki Noda, Hiroyuki Hashizume, Aiji Ohtsuka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 64 ( 2 ) 115 - 120 2010年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods: an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were: Group I, 98.9 +/- 32.6; Group II, 108.5 +/- 27.2; Group III, 50.0 +/- 7.5; and Group IV, 34.5 +/- 12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p < 0.05). In the extension loading test, the mean failure loads were: Group I, 34.0 +/- 12.4; Group II, 51.0 +/- 14.8; Group III, 19.3 +/- 6.0; and Group IV, 14.7 +/- 3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p < 0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.

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掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 22 ( 1 ) 199 - 199 2010年4月

橈骨遠位端部掌側の解剖的研究 Watershed Lineを中心に

清水弘毅, 今谷潤也, 中道亮, 井上円加, 岡田幸正, 高田逸朗, 高橋欣吾, 川上幸雄, 林正典, 西田圭一郎, 吉田晶

中国・四国整形外科学会雑誌 22 ( 1 ) 260 - 260 2010年4月

生物学的製剤使用下の手術治療について生物学的製剤の限界

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S228 - S228 2010年3月

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 野田知之, 西田圭一郎, 尾崎敏文

日本手の外科学会雑誌 27 ( 1 ) S138 - S138 2010年3月

生物学的製剤時代における手術の変遷画像診断と外科的治療画像からみた手術の適応とタイミングどの時期に手術が必要か

西田圭一郎, 橋詰謙三, 中原龍一, 門田康孝, 那須義久, 斎藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 54回・19回 219 - 219 2010年3月

関節リウマチに対する手術療法の進歩と今後関節リウマチに対する上肢手術の進歩と今後

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S231 - S231 2010年3月

Frequent methylation of RASSF１A in synovial sarcoma and the anti-tumor effects of 5-aza-2'-deoxycytidine against synovial sarcoma cell lines.

Numoto K, Yoshida A, Sugihara S, Kunisada T, Morimoto Y, Yoneda Y, Fujita Y, Nishida K, Ouchida M, Ozaki T

J Cancer Res Clin Oncol 136 ( 1 ) 17 - 25 2010年1月

Inflammatory Cytokine-induced Expression of Vasohibin-1 by Rheumatoid Synovial Fibroblasts

Kohei Miyake, Keiichiro Nishida, Yasutaka Kadota, Hiroko Yamasaki, Tatsuyo Nasu, Daisuke Saitou, Katsuyuki Tanabe, Hikaru Sonoda, Yasufumi Sato, Yohei Maeshima, Hirofumi Makino

ACTA MEDICA OKAYAMA 63 ( 6 ) 349 - 358 2009年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Angriogenesis is an essential event in the development of synovial inflammation in rheumatoid arthritis (RA). The aim of the current study was to investigate the expression of vasohibin-1, a novel endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor, in the RA synovium, and to test the effect of inflammatory cytokines on the expression of vasohibin-1 by RA synovial fibroblasts (RASFs). Synovial tissue samples were obtained at surgery from patients with osteoarthritis (OA) and RA, and subjected to immunohistochemistry to investigate the expression and distribution of vasohibin-1 relevant to the degree of synovial inflammation. In an in vitro analysis, RASFs were used to examine the expression of vasohibin-1 and VEGF mRNA by real-time PCR after stimulation with VEGF or inflammatory cytokines under normoxic or hypoxic conditions. The immunohistochemical results showed that vasohibin-1 was expressed in synovial lining cells, endothelial cells, and synovial fibroblasts. In synovial tissue, there was a significant correlation between the expression of vasohibin-1 and histological inflammation score (p = 0.002, r = 0.842). In vitro, stimulation with VEGF induced the expression of vasohibin-1 mRNA in RASFs under normoxic conditions, and stimulation with cytokines induced vasohibin-1 mRNA expression under a hypoxic condition. These results suggest that vasohibin-1 was expressed in RA synovial tissue and might be regulated by inflammatory cytokines.

DOI： 10.18926/AMO/31820

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