研究者詳細 - 西田　圭一郎

論文 - 西田　圭一郎

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関節リウマチの手術4:上肢・その他短母指伸筋腱の停止様式と母指ボタン穴変形との関連について

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 586 - 586 2018年3月

術後早期に復職できたが機能回復には長期間を要したRA患者の一症例

松山宜之, 坂口和輝, 鍋倉由佳, 小川加苗, 藤岡晃, 岡佳純, 堅山佳美, 西田圭一郎, 千田益生

作業療法おかやま 27 54 - 54 2018年3月

リウマチ性疾患の画像1:関節エコーRA 動画画像を教師画像とした深層学習を用いた関節リウマチ患者の超音波画像自動分類

中原龍一, 西田圭一郎, 木曽洋平, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 455 - 455 2018年3月

リウマチ上肢のリハビリと手術〜真の寛解を目指して〜リウマチ上肢のリハビリと手術人工肘関節置換術で社会的・精神的寛解をえられるか

西田圭一郎, 那須義久, 小橋靖子, 橋詰謙三, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 231 - 231 2018年3月

関節リウマチ患者のQOL向上を目指した薬物・手術のcombined therapy 疾患活動性からみた整形外科手術が患者Body Imageに与える影響

西田圭一郎, 小橋靖子, 堀田昌宏, 那須義久, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 220 - 220 2018年3月

単純X線足荷重位正面像における外側趾MTP関節背側脱臼の重症度スコア

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1169 - S1169 2018年3月

関節リウマチに対する手術加療の傾向初回手術例の患者背景

那須義久, 渡辺雅仁, 沖田駿治, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1041 - S1041 2018年3月

関節リウマチ前足部手術における術式別のTUGおよびJSSF-RA scaleの検討

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 木曽洋平, 沖田駿治, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1028 - S1028 2018年3月

関節リウマチ診療における超音波多関節評価・検査時間の短縮の研究

中原龍一, 西田圭一郎, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S313 - S313 2018年3月

短母指伸筋腱の停止様式が母指ボタン穴変形発症に与える影響

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S175 - S175 2018年3月

アバタセプトは関節リウマチにおける周術期合併症を増やすか多施設コホート研究に基づく入れ子型ケースコントロール研究より

伊藤宣, 辻成佳, 中山政憲, 持田勇一, 西田圭一郎, 石川肇, 小嶋俊久, 松本卓巳, 窪田綾子, 望月猛, 桃原茂樹

日本整形外科学会雑誌 92 ( 3 ) S595 - S595 2018年3月

関節リウマチの自己血輸血関節リウマチに対する整形外科手術施行時の術前Hb値と疾患活動性、使用薬剤との関係

那須義久, 西田圭一郎

自己血輸血 31 ( 学術総会 ) S32 - S32 2018年2月

The clinical course of patients with rheumatoid arthritis who underwent orthopaedic surgeries under disease control by tofacitinib. 査読国際誌

Nishida K, Harada R, Nasu Y, Takeshita A, Nakahara R, Matsumeda M, Ozaki T

Modern rheumatology 28 ( 6 ) 1 - 8 2018年1月

Identification of specific protein markers of rheumatoid arthritis in synovial fluid and serum 査読

Keisuke Mihara, Sayuki Kohno, Shiho Hatanaka, Tsutomu Yamasaki, Kei-Ichiro Nishida, Tohru Nakanishi

Journal of Hard Tissue Biology 27 ( 1 ) 55 - 58 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Society of Hard Tissue Regenerative Biology

Rheumatoid arthritis (RA) is a common articular disease characterized by chronic inf lammation, hyperproliferation of synovial cells, and bone destruction. Recently, we showed that small interfering RNA targeting CD81 (siCD81) is therapeutically effective for RA. CD81 belongs to a family of cell-surface proteins (tetraspanins) known to be up-regulated in RA synoviocytes, and siCD81 decreases the expression of synoviolin and TNF-α at the cellular level. We also previously established a highly sensitive sandwich ELISA system using monoclonal antibodies (MAbs) against CD81 by immunization with the outer membrane region of CD81 (LEL), which was overexpressed as a recombinant protein. This assay can be used to detect CD81 in synovial fluids and serum. Here, we identified several specific marker proteins and peptides for diagnosis of RA, including CD81 by using a protein chip system, 2D-gels, and western blotting. These markers can be used for early diagnosis of RA and might contribute to further effective treatment.

DOI： 10.2485/jhtb.27.55

Scopus

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Mast cells exhibiting storong cytoplasmic staining for IgE and high affinity IgE receptor are increased in IgG4-related disease. 査読国際誌

Nishida K, Gion Y, Takeuchi M, Tanaka T, Kataoka RT, Yoshino T, Sato Y

Scientific Reports 8 ( 1 ) 4656 - 4656 2018年

Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M., Ishiguro, N.

International Journal of Rheumatic Diseases 21 ( 10 ) 2018年

Mid-term results of alumina ceramic unlinked total elbow arthroplasty with cement fixation for patients with rheumatoid arthritis

Nishida, K., Hashizume, K., Nasu, Y., Ozawa, M., Fujiwara, K., Inoue, H., Ozaki, T.

Bone and Joint Journal 100B ( 8 ) 2018年

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes 査読

Takahiro Machida, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Masahiro Horita, Ayumu Takeshita, Daisuke Kaneda, Aki Yoshida, Toshifumi Ozaki

INFLAMMATION RESEARCH 66 ( 11 ) 999 - 1009 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER BASEL AG

To investigate whether janus kinase (JAK) inhibitor exhibits a chondro-protective effect against mechanical stress-induced expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMPs) in human chondrocytes.
Normal human articular chondrocytes were seeded onto stretch chambers and incubated with or without tofacitinib (1000 nM) for 12 h before mechanical stimulation or cytokine stimulation. Uni-axial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation, 30 min) was applied and the gene expression levels of type II collagen alpha 1 chain (COL2A1), aggrecan (ACAN), ADAMTS4, ADAMTS5, MMP13, and runt-related transcription factor 2 (RUNX-2) were examined by real-time polymerase chain reaction. Nuclear translocation of RUNX-2 and nuclear factor-kappa B (NF-kappa B) was examined by immunocytochemistry, and phosphorylation of mitogen-activated protein kinase (MAPK) and signaling transducer and activator of transcription (STAT) 3 was examined by western blotting. The concentration of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha in the supernatant was examined by enzyme-linked immunosorbent assay.
COL2A1 and ACAN gene expression levels were decreased by CTS, but these catabolic effects were canceled by tofacitinib. Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. Tofacitinib also reduced CTS-induced nuclear translocation of RUNX-2 and NF-kappa B, and phosphorylation of MAPK and STAT3.
Tofacitinib suppressed mechanical stress-induced expression of ADAMTS4, ADAMTS5, and MMP13 by human chondrocytes through inhibition of the JAK/STAT and MAPK cascades.

DOI： 10.1007/s00011-017-1083-x

Web of Science

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Integrating patients' perceptions into clinical practice guidelines for the management of rheumatoid arthritis in Japan. 査読国際誌

Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern rheumatology 27 ( 6 ) 924 - 929 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified. A focus group with five JRFA executive members was formed to verify the results of the questionnaire. RESULTS: A total of 1470 patients aged 20-79 years old returned the questionnaire. Analysis of the questionnaire data revealed that the topics selected by the CPG task force met the patients' needs. The focus group participants showed reluctance to use the term 'preference' because patients would not want to take any medications but would have to take them out of necessity. CONCLUSIONS: We confirmed that the new CPG successfully addressed clinical issues that were important to both rheumatologists and patients. Clinicians should understand patients' reluctance to take medications and explain the role of each medication well to increase adherence.

DOI： 10.1080/14397595.2016.1276511

PubMed

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Rasch分析を用いたRA患者における上肢機能評価の検討

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 兼田大輔, 竹下歩, 大橋秀基, 木曾洋平, 沖田駿治, 渡辺雅仁, 高杉幸司, 藤森美鈴, 江澤和彦

日本関節病学会誌 36 ( 3 ) 263 - 263 2017年10月

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