研究者詳細 - 西田　圭一郎

論文 - 西田　圭一郎

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慢性疼痛患者におけるロコモティブシンドローム有病率とその特徴

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S934 - S934 2021年3月

生物学的製剤と手術当科におけるリウマチ外科手術1569例の患者背景

那須義久, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 343 - 343 2021年3月

骨折を伴ったリウマチ肘に対するPROSNAPを用いた人工肘関節全置換術の治療成績

堀田佳史, 西田圭一郎, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 602 - 602 2021年3月

関節リウマチ超音波検査におけるデジタルカメラ画像とAIを用いたボディーマーク付与

中原龍一, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 555 - 555 2021年3月

ロモソズマブ治療において骨粗鬆症の前治療が与える影響、投与1年時の効果予測因子について

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 高杉幸司, 江澤和彦, 井上貴絵, 藤田慎一朗, 與座未来, 金谷麻未, 新名早希子, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 610 - 610 2021年3月

Does exercise therapy improve patient-reported outcomes in rheumatoid arthritis? A systematic review and meta-analysis for the update of the 2020 JCR guidelines for the management of rheumatoid arthritis. 国際誌

Yasumori Sobue, Toshihisa Kojima, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Takahiko Sugihara, Yohei Seto, Eiichi Tanaka, Takeo Nakayama, Shintaro Hirata, Atsuko Murashima, Akio Morinobu, Masaaki Mori, Masayo Kojima, Yutaka Kawahito, Masayoshi Harigai

Modern rheumatology 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system. METHODS: We searched PubMed, Japana Centra Revuo Medicina Web, and the Cochrane Library (from 2009 to 2018) to identify articles that evaluated PROs of exercise therapy and RA disease activity. RESULTS: A total of 662 articles were identified, including nine RCTs, and meta-analyses were performed on six RCTs on systemic exercise therapy and three RCTs on upper extremity exercise therapy. Analyzed exercise therapies were diverse, differing in target population, intervention method, and duration. Significant improvements were observed in the Health Assessment Questionnaire Disability Index (mean difference -0.35, 95% confidence interval (CI): -0.60 to -0.10), pain (standardized mean difference -2.04, 95% CI: -3.77 to -0.32), and SF-36. For upper extremity exercise therapy, significant improvements in PROs (Disabilities of the Arm, Shoulder, and Hand Questionnaire, Michigan Hand Outcome Questionnaire) were observed. CONCLUSION: Exercise therapy in RA treatment improves patient subjective assessment of pain, physical function, and quality of life.

DOI： 10.1080/14397595.2021.1886653

PubMed

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整形外科からみた treat to target - 何を重視するか -

西田圭一郎

整形・災害外科 64 ( 2 ) 131 - 140 2021年2月

Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis

Yuko Kaneko, Yutaka Kawahito, Masayo Kojima, Takeo Nakayama, Shintaro Hirata, Mitsumasa Kishimoto, Hirahito Endo, Yohei Seto, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern Rheumatology 31 ( 1 ) 61 - 69 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Objectives: To evaluate the efficacy and safety of tacrolimus in adult patients with rheumatoid arthritis (RA) by using the GRADE approach. Methods: We searched PubMed, Japana Centra Revuo Medicina Web (Ichu-shi web), and the Cochrane Database of Systematic Reviews. Articles fulfilling the predefined inclusion criteria were appraised and used for meta-analysis. The primary outcomes were American College of Rheumatology 20 (ACR20) and serum creatinine elevation. Other outcomes included ACR50, ACR70, changes in C-reactive protein, modified Health Assessment Questionnaire Disability Index, gastrointestinal disorders, metabolic and nutritional disorders, and infections and infestations. Results: We identified five randomized controlled studies, four of which compared tacrolimus to placebo and were included in the meta-analysis. The risk ratio of ACR20 achievement was 1.71 (95% confidence interval [CI] 1.20-2.42) for 1-2 mg/day and 2.30 (95% CI 1.79-2.96) for 3 mg/day. The risk ratio of creatinine elevation was 1.95 (95% CI 1.18-3.23) for 1-2 mg/day and 3.81 (95% CI 2.43-5.99) for 3 mg/day. Conclusion: Tacrolimus is effective with acceptable safety in the management of RA.

DOI： 10.1080/14397595.2020.1719607

Web of Science

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RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis. 国際誌

Ayumu Takeshita, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Daisuke Kaneda, Hideki Ohashi, Toshifumi Ozaki

PloS one 16 ( 7 ) e0254268 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the expression and localization of the receptor activator nuclear factor κB ligand (RANKL) in cartilage from patients with rheumatoid arthritis (RA) of relevance to cartilage degeneration. We also examined the role of exogenous lymphotoxin (LT)-α on RANKL expression in human chondrocytes and its effect on in vitro osteoclast differentiation. Cartilage and synovial fluid samples were obtained from 45 patients undergoing total joint replacement surgery or joint puncture, including 24 patients with osteoarthritis (OA) and 21 patients with RA. RANKL expression in articular cartilage was examined by immunohistochemistry. LT-α concentrations in synovial fluid were measured using an enzyme-linked immunosorbent assay (ELISA). Normal human chondrocytes were stimulated with LT-α, and the relative mRNA levels of RANKL, osteoprotegerin (OPG), matrix metalloproteinase-9, and vascular endothelial growth factor were examined by real-time polymerase chain reaction. Soluble RANKL protein in culture media was measured using ELISA, and membrane-bound RANKL protein in cells was examined by western blotting. Co-cultures of human chondrocytes with peripheral blood mononuclear cells (PBMCs) were stimulated with macrophage-colony stimulating factor and LT-α, and osteoclast differentiation was evaluated by staining for tartrate-resistant acid phosphatase. LT-α concentrations were higher in RA synovial fluid than in OA samples. The population of RANKL-positive chondrocytes of RA cartilage was higher than that of OA cartilage, and correlated with cartilage degeneration. Stimulation of cultured human chondrocytes by LT-α increased RANKL expression, the RANKL/OPG ratio, and angiogenic factors. Membrane-bound RANKL in chondrocytes was up-regulated after stimulation of LT-α, whereas soluble RANKL in culture medium did not increase. Co-cultures of human chondrocytes and PBMCs demonstrated that LT-α stimulated human chondrocytes to produce RANKL and induced osteoclastic differentiation of PBMCs. RANKL produced by chondrocytes may contribute to cartilage destruction during RA and LT-α could promote the expression of RANKL in human chondrocytes.

DOI： 10.1371/journal.pone.0254268

PubMed

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Swanson型シリコンインプラントを用いた母指MP関節形成術後30年経過した1例

沖田駿治, 石川肇, 阿部麻美, 中園清, 村澤章, 西田圭一郎

関節の外科 48 ( 2 ) 72 - 72 2021年