研究者詳細 - 西田　圭一郎

LRP4 and Agrin Are Modulated by Cartilage Degeneration and Involved in β-Catenin Signaling in Human Articular Chondrocytes

Shuichi Naniwa, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Takashi Ohtsuki, Yoshifumi Hotta, Noriyuki Shimizu, Chinatsu Ichikawa, Deting Lin, Noriaki Otsuka, Toshifumi Ozaki

International Journal of Molecular Sciences 26 ( 3 ) 1007 - 1007 2025年1月

掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

We investigated the roles of low-density lipoprotein receptor-related protein (LRP) 4 and its ligand Agrin in the pathophysiology of cartilage degeneration. Immunohistochemical analysis of human normal articular cartilage and cartilage tissues from patients with osteoarthritis (OA) obtained during surgery of the knee joint showed marked LRP4 expression in the early stages of OA, which then decreased with cartilage degeneration, whereas Agrin was consistently increased with cartilage degeneration. In normal human articular chondrocytes (NHACs), mild cyclic tensile strain (CTS) (0.5 Hz, 5% elongation, 2 h) increased the expression of LRP4 and aggrecan (ACAN), while intense CTS (0.5 Hz, 10% elongation, 6 h) increased the expression of Agrin without affecting LRP4 expression. Treatment with recombinant human (rh) Agrin downregulated the mRNA expression of LRP4 and ACAN, but upregulated the expression of LRP5/6, SRY-box transcription factor 9 (SOX9), Runt-related transcription factor 2 (RUNX2), and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4). Immunocytochemistry and Western blot analysis showed that rhAgrin treatment upregulated the expression of β-catenin and SOX9. Agrin knockdown by siAGRN transfection partially reduced the nuclear protein expression of β-catenin, which was increased with intense CTS. LRP4 knockdown by siLRP4 transfection increased the expression of LRP5/6, SOX9, RUNX2, ADAMTS-4, and Agrin. These results suggested that intense CTS increases the expression of Agrin, which might interfere with the role of LRP4 in the inhibition of LRP5/6 and their downstream β-catenin signaling, leading to cartilage degeneration.

DOI： 10.3390/ijms26031007

Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes 査読

Takashi Ohtsuki, Ikumi Sato, Ren Takashita, Shintaro Kodama, Kentaro Ikemura, Gabriel Opoku, Shogo Watanabe, Takayuki Furumatsu, Hiroshi Yamada, Mitsuru Ando, Kazunari Akiyoshi, Keiichiro Nishida, Satoshi Hirohata

International Journal of Molecular Sciences 25 ( 22 ) 11942 2024年11月

関節リウマチの前足部変形の痛みと保存的・外科的治療査読

西田圭一郎, 那須義久, 中原龍一, 植田昌敬, 鷹取亮, 鉄永倫子

日本運動器疼痛学会誌 16 91 - 95 2024年11月

The use of biologic disease-modifying antirheumatic drugs does not increase surgical site infection or delayed wound healing after orthopaedic surgeries for rheumatoid arthritis 国際誌

Yohei Kiso, Keiichiro Nishida, Ryozo Harada, Yoshihisa Nasu, Ryuichi Nakahara, Yoshifumi Hotta, Shuichi Naniwa, Toshifumi Ozaki

Modern Rheumatology 35 ( 2 ) 265 - 272 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objective

To investigate the effect of the use of biologic disease-modifying antirheumatic drugs (bDMARDs) on surgical site infection (SSI) and delayed wound healing (DWH) in rheumatoid arthritis (RA) patients undergoing orthopaedic surgery.

Methods

We retrospectively reviewed the records of 965 elective orthopaedic procedures undertaken in RA patients. The incidences of SSI and DWH were compared between the bDMARDs user and nonuser groups. Subsequently, univariate and multivariate logistic regression analyses were performed to evaluate risk factors for SSI and DWH after propensity score matching. The incidence of postoperative flare-up was also examined.

Results

In 965 procedures, SSI and DWH were identified in 12 and 28 cases, respectively. SSI and DWH were identified in 3 and 17 of 414 procedures treated with bDMARDs, respectively. Flare-up occurred in 21 cases. Propensity score matching identified 315 cases in both groups, with no significant difference in incidence between the two groups. No risk factors for SSI were identified, whereas age, diabetes mellitus, foot and ankle surgery, and a history of musculoskeletal-related infection were identified as risk factors for DWH.

Conclusion

The use of bDMARDs was not associated with an increased incidence of SSI or DWH, with the incidence of flare-up being relatively low.

DOI： 10.1093/mr/roae089

関節軟骨におけるLRP4とAGRINの発現調節因子とβ-catenin signalへの影響

その他リンク： https://academic.oup.com/mr/article-pdf/35/2/265/60523967/roae089.pdf

テリボンオートインジェクターの投与時反応について

是友行美, 原田遼三, 高杉幸司, 江澤和彦, 藤田慎一郎, 後藤京子, 山本渉, 中原龍一, 那須義久, 西田圭一郎

日本骨粗鬆症学会雑誌 10 ( Suppl.1 ) 588 - 588 2024年9月

浪花崇一, 市川千夏, 林徳てい, 志水紀之, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本整形外科学会雑誌 98 ( 8 ) S1934 - S1934 2024年9月

Insomnia among patients with chronic pain: A retrospective study

Masataka Ueda, Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Ryo Takatori, Hisakazu Shitozawa, Koji Uotani, Kennsuke Shinohara, Yoshiaki Oda, Toshifumi Ozaki

Medicine 103 ( 32 ) e39113 - e39113 2024年8月

掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Insomnia can coexist with chronic pain and is a major cause of rapidly increasing medical expenses. However, insomnia has not been fully evaluated in patients with chronic pain. This retrospective study aimed to identify the risk factors for insomnia in patients with chronic non-cancer pain. A total of 301 patients with chronic non-cancer pain were enrolled. Patients with the Athens insomnia scale scores ≥ 6 and < 6 were classified into insomnia (+) and insomnia (−) groups, respectively. All patients completed self-report questionnaires as part of their chronic pain treatment approach. Univariate and multivariate analyses were performed to predict insomnia. We found that 219 of 301 (72.8%) patients met the AIS criteria for insomnia. Significant differences were depicted between patients with and without insomnia in terms of body mass index, numeric rating scale, pain catastrophizing scale, hospital anxiety, and depression scale (HADS), pain disability assessment scale, EuroQol 5 dimension (EQ5D), and pain self-efficacy questionnaire. Multiple regression analysis identified the numeric rating scale, HADS, and EQ5D scores as factors related to insomnia in patients with chronic non-cancer pain. Anxiety, depression, and disability were associated with a greater tendency toward insomnia. HADS and EQ5D scores are useful screening tools for preventing insomnia in patients with chronic non-cancer pain.

DOI： 10.1097/md.0000000000039113

マルチモーダル大規模言語を用いた自動病理画像解析

中原龍一, 竹内孔一, 那須義久, 長谷井嬢, 高橋康, 西田圭一郎, 尾崎敏文

日本関節病学会誌 43 ( 2 ) 252 - 252 2024年6月

大規模言語モデルの外部文書読み込み(RAG)を用いた医療文書の自動Q&A開発

那須義久, 竹内孔一, 中原龍一, 長谷井嬢, 西田圭一郎, 尾崎敏文

日本関節病学会誌 43 ( 2 ) 251 - 251 2024年6月

当院における関節リウマチに対する手部手術の変遷(2004-2022)

志水紀之, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 43 ( 2 ) 156 - 156 2024年6月

関節リウマチ手外科手術における手術部位感染/創傷治癒遅延の発生率とb/ts DAMRDs使用の影響

市川千夏, 志水紀之, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 43 ( 2 ) 156 - 156 2024年6月

関節リウマチ手外科手術における手術部位感染/創傷治癒遅延の発生率とb/ts DAMRDs使用の影響

市川千夏, 志水紀之, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 43 ( 2 ) 156 - 156 2024年6月

当院における関節リウマチに対する手部手術の変遷(2004-2022)

志水紀之, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 43 ( 2 ) 156 - 156 2024年6月

大規模言語モデルの外部文書読み込み(RAG)を用いた医療文書の自動Q&A開発

那須義久, 竹内孔一, 中原龍一, 長谷井嬢, 西田圭一郎, 尾崎敏文

日本関節病学会誌 43 ( 2 ) 251 - 251 2024年6月

マルチモーダル大規模言語を用いた自動病理画像解析

中原龍一, 竹内孔一, 那須義久, 長谷井嬢, 高橋康, 西田圭一郎, 尾崎敏文

日本関節病学会誌 43 ( 2 ) 252 - 252 2024年6月

変形性膝関節症に対するCoolief疼痛管理用高周波システムを用いた治療経験

原田遼三, 西田圭一郎, 那須義久, 中原龍一

日本関節病学会誌 43 ( 2 ) 266 - 266 2024年6月

若年者に対する人工関節手術:克服すべき困難と成功の秘訣若年例に対する人工肘関節置換術

那須義久, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 43 ( 2 ) 213 - 213 2024年6月

Comparison of early clinical outcome in carpal tunnel release - mini-open technique with palmar incision vs. endoscopic technique with wrist crease incision. 査読国際誌

Ryo Nakamichi, Taichi Saito, Yasunori Shimamura, Masanori Hamada, Keiichiro Nishida, Toshifumi Ozaki

BMC musculoskeletal disorders 25 ( 1 ) 251 - 251 2024年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The purpose of this study was to examine two techniques for Carpal Tunnel Syndrome, mini-Open Carpal Tunnel Release (mini-OCTR) and Endoscopic Carpal Tunnel Release (ECTR), to compare their therapeutic efficacy. METHODS: Sixteen patients who underwent mini-OCTR in palmar incision and 17 patients who underwent ECTR in the wrist crease incision were included in the study. All patients presented preoperatively and at 1, 3, and 6 months postoperatively and were assessed with the Visual Analogue Scale (VAS) and the Disabilities of Arm, Shoulder and Hand Score (DASH). We also assessed the pain and cosmetic VAS of the entire affected hand or surgical wound, and the patient's satisfaction with the surgery. RESULTS: In the objective evaluation, both surgical techniques showed improvement at 6 months postoperatively. The DASH score was significantly lower in the ECTR group (average = 3 months: 13.6, 6 months: 11.9) than in the mini-OCTR group (average = 3 months: 27.3, 6 months: 20.6) at 3 and 6 months postoperatively. Also, the pain VAS score was significantly lower in the ECTR group (average = 17.1) than in the mini-OCTR group (average = 36.6) at 3 months postoperatively. The cosmetic VAS was significantly lower in the ECTR group (average = 1 month: 15.3, 3 months: 12.2, 6 months: 5.41) than in the mini-OCTR group (average = 1 month: 33.3, 3 months: 31.2, 6 months: 24.8) at all time points postoperatively. Patient satisfaction scores tended to be higher in the ECTR group (average = 3.3) compared to the mini-OCTR group (average = 2.7). CONCLUSIONS: ECTR in wrist increase incision resulted in better pain and cosmetic recovery in an early postoperative phase compared with mini-OCTR in palmar incision. Our findings suggest that ECTR is an effective technique for patient satisfaction.

DOI： 10.1186/s12891-023-07151-w

Safety and effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: Up to 3-year results from a postmarketing surveillance study

Hideto Kameda, Keiichiro Nishida, Toshihiro Nanki, Akira Watanabe, Yukiya Oshima, Shigeki Momohara

Modern Rheumatology 34 ( 6 ) 1103 - 1114 2024年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objectives

To report up to 3-year safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a postmarketing surveillance study.

Methods

Patients enrolled previously completed 24 weeks of CZP in the 24-week postmarketing surveillance study. Adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes were 28-joint Disease Activity Score with erythrocyte sedimentation rate and European Alliance of Associations for Rheumatology response. Week 24–156 safety and Week 0–52 effectiveness data are reported here.

Results

A total of 781 patients were enrolled, with 735 and 376 patients evaluated for safety and effectiveness, respectively. Within the safety set, 17.8% (131/735) of patients reported ADRs; 9.4% (69/735) reported serious ADRs. Among patients with history of respiratory, thoracic, and mediastinal disorders, 38.4% (28/73) reported ADRs. The most frequent ADRs were infections and infestations (11.8%; 87/735); skin and subcutaneous tissue disorders (1.9%; 14/735); respiratory, thoracic, and mediastinal disorders (1.6%; 12/735). Mean 28-joint Disease Activity Score with erythrocyte sedimentation rate reduced from 4.6 (Week 0) to 2.8 (Week 52). At Week 52, 51.8% (161/311) of patients achieved European Alliance of Associations for Rheumatology Good response.

Conclusions

The long-term safety and effectiveness of CZP in the real-world setting in Japan were consistent with previously reported data; no new safety signals were identified.

DOI： 10.1093/mr/roae019

非転位型の橈骨遠位端骨折において骨折部位,Lister結節形状は長母指伸筋腱断裂に影響する

その他リンク： https://academic.oup.com/mr/article-pdf/34/6/1103/60153600/roae019.pdf

リウマチ性疾患の手術(休薬・合併症・その他) 関節リウマチの整形外科手術において,周術期の休薬は非休薬に比べて術後合併症を増やすか

伊藤宣, 石川肇, 辻成佳, 中山政憲, 西田圭一郎, 望月猛, 蛯名耕介, 小嶋俊久, 松本卓巳, 窪田綾子, 中島新, 金子敦史, 松下功, 原良太, 櫻庭康司, 赤崎幸穂, 松原司, 持田勇一, 神戸克明, 桃原茂樹

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 645 - 645 2024年3月

斎藤太一, 近藤秀則, 古谷友希, 中道亮, 島村安則, 西田圭一郎, 今谷潤也, 尾崎敏文

日本整形外科学会雑誌 98 ( 3 ) S781 - S781 2024年3月

人工膝関節置換術後の関節リウマチ患者における生物学的製剤・JAK阻害剤使用とD-dimer値の関係

志水紀之, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 846 - 846 2024年3月

自動統計のための日本語大規模言語モデルを用いたカルテサマリーからの情報抽出

中原龍一, 西田圭一郎, 那須義久, 原田遼三, 浪花崇一, 志水紀之, 市川千夏, 高橋康, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 714 - 714 2024年3月

リウマチ性疾患の手術(上肢) 関節リウマチに対するMCP人工関節置換術と手関節・手指伸筋腱同時手術症例の検討

市川千夏, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 532 - 532 2024年3月

リウマチ性疾患の手術(上肢) AVANTAとINTEGRAを用いたMCP人工指関節置換術の術後短期成績の比較

浪花崇一, 市川千夏, 志水紀之, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 68回 532 - 532 2024年3月

Consensus statement on the management of late-onset rheumatoid arthritis

Masayo Kojima, Takahiko Sugihara, Yutaka Kawahito, Toshihisa Kojima, Yuko Kaneko, Hajime Ishikawa, Asami Abe, Kazuo Matsui, Shintaro Hirata, Mitsumasa Kishimoto, Eiichi Tanaka, Akio Morinobu, Motomu Hashimoto, Isao Matsushita, Toshihiko Hidaka, Toshihiro Matsui, Keiichiro Nishida, Shuji Asai, Hiromu Ito, Ryozo Harada, Masayoshi Harigai

Modern Rheumatology 34 ( 6 ) 1095 - 1102 2024年2月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objectives

Late-onset rheumatoid arthritis (LORA), which has been increasing in recent years, lacks evidence for initial treatment. Japanese rheumatology experts recognized this gap and addressed it by developing consensus statements on the first clinical application of LORA.

Methods

These statements were created following an introductory discussion about treatment fundamentals, which included a review of existing literature and cohort data. The steering committee created a draft, which was refined using a modified Delphi method that involved panel members reaching a consensus. The panel made decisions based on input from geriatric experts, clinical epidemiologists, guideline developers, patient groups, and the LORA Research Subcommittee of the Japan College of Rheumatology.

Results

The consensus identified four established facts, three basic approaches, and six expert opinions for managing LORA. Methotrexate was recommended as the primary treatment, with molecular-targeted agents being considered if treatment goals cannot be achieved. An emphasis was placed on assessing the lives of older patients due to challenges in risk management and methotrexate accessibility caused by comorbidities or cognitive decline.

Conclusions

The experts substantiated and refined 13 statements for the initial treatment of LORA. To validate these claims, the next is to conduct a registry study focusing on new LORA cases.

DOI： 10.1093/mr/roae011

その他リンク： https://academic.oup.com/mr/article-pdf/34/6/1095/60153479/roae011.pdf

High Fracture Rate of AVANTA Silicone Implant Following Arthroplasty of the Thumb MCP Joint of Rheumatoid Arthritis Patients with Boutonniere Deformities. 査読

Daisuke Kaneda, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Ryozo Harada, Yoshifumi Hotta, Shuichi Naniwa, Toshifumi Ozaki

Acta medica Okayama 78 ( 1 ) 71 - 78 2024年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

We retrospectively investigated the mid-term outcomes of arthroplasty using the AVANTA silicone implant for thumb metacarpophalangeal (MCP) joints with boutonniere deformity in patients with rheumatoid arthritis (RA). This study involved 36 thumbs of 33 RA patients with a mean follow-up period of 5.1 years (range, 2.0-13.3). Postoperatively, the mean extension was significantly increased and the mean flexion was significantly decreased (p<0.001, p<0.001, respectively), resulting in the mean arc of range of motion (ROM) shifting in the direction of extension after surgery. Implant fracture was observed in 10 thumbs (28%), and 4 of these (11%) underwent revision surgery. The survivorship with implant fracture and revision surgery as endpoints were 73.4% and 91.8% at 5 years, respectively. The preoperative arc of ROM and the postoperative flexion range of the implant-fracture group were significantly greater than those in the no-implant-fracture group (p=0.039, 0.034, respectively). These results suggest the importance of patient education and careful rehabilitation to prevent excessive flexion. Overall, the AVANTA silicone implant showed a relatively high rate of implant fracture at our institute.

DOI： 10.18926/AMO/66673

Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes 査読

Yoshifumi Hotta, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Shuichi Naniwa, Noriyuki Shimizu, Chinatsu Ichikawa, Deting Lin, Tomohiro Fujiwara, Toshifumi Ozaki

International Journal of Molecular Sciences 2024年1月

Intra-Articular Corrective Osteotomy for Distal Radial Intra-Articular Malunion Using Patient-Matched Instruments: A Prospective, Multicenter, Open-Label, Single-Arm Trial. 査読国際誌

Kunihiro Oka, Satoshi Miyamura, Ryoya Shiode, Hiroyuki Tanaka, Norimasa Iwasaki, Daisuke Kawamura, Kazuki Sato, Takuji Iwamoto, Michiro Yamamoto, Keiichiro Nishida, Yasunori Shimamura, Tomomi Yamada, Seiji Okada, Tsuyoshi Murase

JB & JS open access 9 ( 3 ) e24 2024年

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Corrective osteotomy for intra-articular malunion is a challenging procedure. However, recent advancements, including patient-matched instruments created on the basis of preoperative computer simulation, enable accurate intra-articular correction. We hypothesized that intra-articular corrective osteotomy using patient-matched instruments for the treatment of distal radial intra-articular malunion would reduce intra-articular deformity and restore wrist function at 12 months of follow-up. METHODS: This prospective study included 12 patients with distal radial intra-articular malunion who underwent intra-articular corrective osteotomy external to the joint using patient-matched instruments. The primary end point was the maximum step-off on the articular surface of the distal radius, measured with use of computed tomography (CT), with an expected postoperative value of ≤1.5 mm. The secondary end points included the gap of the articular surface; range of motion; grip strength; pain evaluated using a visual analog scale (VAS); patient satisfaction; Disabilities of the Arm, Shoulder and Hand (DASH) score; and Patient-Rated Wrist Evaluation (PRWE) score. A mean postoperative step-off of ≤1.5 mm for the primary end point was assessed with use of the 1-sample t test. The secondary end points were assessed with use of the Dunnett multiple comparison test. RESULTS: The average step-off significantly improved from 3.75 ± 1.04 mm preoperatively to 0.51 ± 0.40 mm at the 52-week postoperative follow-up and was maintained within 1.5 mm. The average wrist and forearm range of motion, VAS score, grip strength, DASH score, and PRWE score significantly improved. Eleven patients were either very satisfied or satisfied with their outcomes. CONCLUSIONS: The use of patient-matched instruments could contribute to improving postoperative outcomes of intra-articular corrective osteotomy procedures involving the distal radius. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

DOI： 10.2106/JBJS.OA.24.00026

A preliminary survey of rheumatologists on the management of late-onset rheumatoid arthritis in Japan

Satoshi Takanashi, Yuko Kaneko, Yutaka Kawahito, Takashi Kida, Takahiko Sugihara, Toshihisa Kojima, Ryozo Harada, Michinori Ishitoku, Shintaro Hirata, Motomu Hashimoto, Toshihiko Hidaka, Asami Abe, Hajime Ishikawa, Hiromu Ito, Mitsumasa Kishimoto, Kazuo Matsui, Toshihiro Matsui, Isao Matsushita, Akira Onishi, Akio Morinobu, Keiichiro Nishida, Shuji Asai, Eiichi Tanaka, Masayoshi Harigai, Masayo Kojima

Internal Medicine 2024年

Unlinked TEAを第一選択とする治療戦略

那須義久, 西田圭一郎, 中原龍一, 大塚憲昭, 市川千夏, 志水紀之, 浪花崇一, 尾崎敏文

関節の外科 51 ( 2 ) 51 - 51 2024年

関節リウマチ患者における人工関節置換術のリスクファクターの検討

志水紀之, 大塚憲昭, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

関節の外科 51 ( 2 ) 70 - 70 2024年

最適な治療を目指した周術期管理 JAK阻害剤

西田圭一郎, 市川千夏, 那須義久, 中原龍一, 原田遼三, 浪花崇一, 志水紀之, 林徳てい, 大塚憲昭

関節の外科 51 ( 2 ) 40 - 40 2024年

前方及び後方アプローチを併用した尺骨鉤状突起および肘頭骨折を伴う肘関節脱臼開放骨折の1例

古谷友希, 齋藤太一, 中道亮, 島村安則, 西田圭一郎, 尾崎敏文

日本肘関節学会雑誌 31 ( 1 ) S84 - S84 2024年

The Effectiveness of Rehabilitation after Open Surgical Release for Trigger Finger: A Prospective, Randomized, Controlled Study 査読

Taichi Saito, Ryo Nakamichi, Ryuichi Nakahara, Keiichiro Nishida, Toshifumi Ozaki

Journal of Clinical Medicine 12 ( 22 ) 7187 - 7187 2023年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

Background: It is not clear whether rehabilitation after surgery for trigger finger is effective. The aim of this study was to reveal its effectiveness for trigger finger. Methods: This study was a randomized, controlled trial that included patients who underwent operations for trigger fingers. The patients in the rehabilitation group had postoperative occupational therapy (OT) for 3 months, while the patients in the control group were not referred for rehabilitation but received advice for a range of motion exercises. We evaluated the severity of trigger finger, Disability of Arm-Shoulder-Hand (DASH) score, pain-visual analogue scale (VAS), grip strength, whether they gained a full range of motion (ROM), and complications before and after surgery. Results: Finally, 29 and 28 patients were included in the control and rehabilitation groups, respectively. At final follow-up, the DASH score, grip strength, and ROM were significantly improved in the rehabilitation group compared to that preoperatively. At final follow-up, pain was significantly improved in both groups from that preoperatively. There were no significant differences in the results, including the DASH score, grip strength, ROM and pain-VAS between the control and rehabilitation groups at the final follow-up. Subgroup analysis showed that there is a significant difference in the DASH score of patients doing housework or light work and those with a duration of symptoms >12 months between the control and rehabilitation groups at the final follow-up.

DOI： 10.3390/jcm12227187

ChatGTP と paper mills

西田圭一郎

整形外科 74 ( 11 ) 1168 - 1168 2023年11月

変形性関節症の画像診断，バイオマーカーのトピックス

西田圭一郎

関節外科 42 ( 10 ) 16 - 22 2023年10月

関節リウマチ患者の整形外科手術における手術部位感染，創傷治癒遅延の治療と生物学的製剤使用の関係

浪花崇一, 那須義久, 西田圭一郎

別冊整形外科 1 ( 84 ) 149-153 2023年10月

慢性疼痛患者の破局的思考が身体的機能と活動能力に与える影響 1年間の継時的推移の特徴

太田晴之, 齋藤圭介, 横山暁大, 堅山佳美, 濱田全紀, 鉄永倫子, 西田圭一郎, 尾崎敏文

日本運動器理学療法学会学術大会抄録集 11回 348 - 348 2023年10月

完全 Web 化された医工連携の試み：関節可動域自動計測システムの開発査読

速川湧気, 吉岡健太郎, 鈴木諒, 中原龍一, 那須義久, 西田圭一郎, 尾﨑敏文

中・四整会誌 35 ( 2 ) 225 - 230 2023年9月

深層学習と民生用 3D センサを用いた低コスト高精度肘関節可動域自動計測システムの試み査読

鈴木諒, 吉岡健太郎, 速川湧気, 中原龍一, 那須義久, 西田圭一郎, 尾﨑敏文

中・四整会誌 35 ( 2 ) 219 - 224 2023年9月

Wrist arthrodesis combined with a bulk bone allograft for implant loosening after total wrist arthroplasty: a case report. 査読国際誌

Yoshihisa Nasu, Keiichiro Nishida, Masamitsu Natsumeda, Ryuichi Nakahara, Ryozo Harada, Toshifumi Ozaki

Modern rheumatology case reports 2023年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Total wrist arthroplasty is a challenging procedure for wrist joints severely destroyed by rheumatoid arthritis. The most common postoperative complication of total wrist arthroplasty is the loosening of the carpal component. Revision surgeries for failed total wrist arthroplasties can be complicated owing to severe bone loss and concomitant soft-tissue problems. Here we report a case (68-year-old woman with a history of rheumatoid arthritis for 24 years) of severe aseptic loosening of semi-constrained total wrist arthroplasty and its salvage surgery. During the primary arthroplasty procedure, severe instability at the second through fifth carpometacarpal joints was observed, and arthrodesis of these joints was required. The radiographs obtained nine months after surgery showed loosening of the carpal component. Subsequently, she suffered a stroke, resulting in a loss of follow-up, and higher stress was loaded on her upper extremities during standing and walking. In the radiograph taken at her revisit 25 months after the primary surgery, the subsidence of the carpal component progressed, and loosening of the radial component was observed. Total wrist arthrodesis was performed using a bulk bone allograft of the femoral head, combined with a penetrating Wrist Fusion Rod®. Rapid bone union was achieved without soft tissue irritation. We conclude that wrist arthrodesis with a bulk bone allograft combined with an intramedullary nail is a reasonable option for failed total wrist arthroplasty.

DOI： 10.1093/mrcr/rxad048

大規模言語モデル(AI)の医師国家試験解答解析 ChatGPTとGPT-4の比較

中原龍一, 西田圭一郎, 那須義久, 堀田佳史, 浪花崇一, 志水紀之, 高橋康, 長谷川嬢

日本整形外科学会雑誌 97 ( 8 ) S1609 - S1609 2023年8月

新しい関節リウマチ診療ガイドラインとアバタセプトの位置付け

西田圭一郎

大阪臨床整形外科医会会報 ( 49 ) 2023 - 2023 2023年7月

Influence of Janus kinase inhibitors on early postoperative complications in patients with rheumatoid arthritis undergoing orthopaedic surgeries 査読

Keiichiro Nishida, Ryozo Harada, Yoshihisa Nasu, Shuichi Naniwa, Ryuichi Nakahara, Yoshifumi Hotta, Noriyuki Shimizu, Deting Lin, Toshifumi Ozaki

Modern Rheumatology 34 ( 3 ) 466 - 473 2023年6月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objective

We retrospectively reviewed the records of rheumatoid arthritis (RA) patients who underwent orthopaedic surgery to examine the influence of the perioperative use of Janus kinase (JAK) inhibitors on early postoperative complications.

Patients and Methods

Thirty-two patients with RA under disease control with JAK inhibitors who underwent 49 orthopaedic procedures were included in the study. Patient records after surgery were investigated for surgical site infection (SSI), delayed wound healing (DWH), a flare-up of the disease, preoperative and postoperative absolute lymphocyte counts (ALCs), venous thromboembolism, and other postoperative complications.

Results

JAK inhibitors were continued during the perioperative period in 31 procedures. In the remaining 18 procedures, JAK inhibitors were discontinued perioperatively with a mean discontinuation period of 2.4 days. No instances of SSI were identified in any patient during at least 90 days’ follow-up, while DWH was seen in one patient. Disease flare-up was noted in two patients after 3 and 9 days of discontinuation of JAK inhibitors, respectively. The ALCs significantly decreased on postoperative Day 1 (P &lt; .0001), and there was a significant correlation between pre- and post-one-day ALCs (r = 0.75, P &lt; .0001).

Conclusion

JAK inhibitors seem to be safe during the perioperative period of orthopaedic surgery.

DOI： 10.1093/mr/road047

【知っておきたい関節痛のみかた・考えかた】実際の診察室で困ること関節痛をきたす患者をいつ外科医へコンサルトすべきか

その他リンク： https://academic.oup.com/mr/article-pdf/34/3/466/57109151/road047.pdf

J-SC人工肘関節の連結部に破損を生じた1例

那須義久, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 270 - 270 2023年6月

関節リウマチ患者に対する前足部切除関節形成術後の骨棘切除術

志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 249 - 249 2023年6月

両手関節炎様の所見を呈した腱黄色腫の1例

浪花崇一, 志水紀之, 林徳てい, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 42 ( 3 ) 214 - 214 2023年6月

骨吸収抑制薬長期使用下で高度変形肘を伴う関節リウマチ患者に生じた尺骨非定形骨折の一例

原田遼三, 西田圭一郎, 那須義久, 中原龍一

日本関節病学会誌 42 ( 3 ) 208 - 208 2023年6月

大規模言語モデル(ChatGPT)による医師国家試験解答解析

中原龍一, 西田圭一郎, 高橋康, 那須義久, 堀田佳史, 浪花崇一, 志水紀之, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 191 - 191 2023年6月

那須義久, 西田圭一郎

診断と治療 111 ( 6 ) 823 - 828 2023年6月

記述言語：日本語出版者・発行元：(株)診断と治療社

＜文献概要＞Headline 1 関節リウマチでは,薬物療法が適切に行われたうえで,残存する関節症状に対する非薬物療法が検討される.関節注射やリハビリテーション,装具療法などの保存療法が無効な場合は手術治療が検討される.2 関節破壊・変形が軽度な段階から高度に進行した段階まで,様々な手術方法の適応があるが,関節構造を温存し,より高度な機能再建を求めるならば早期に手術治療を行ったほうがよい.3 合併する腱断裂,絞扼性神経障害や脊椎脊髄障害などの進行にも注意する必要があり,発症・進行が疑われる場合は整形外科へのコンサルトが必要である.4 手術治療のタイミングを逸さないためには,手術適応の判断だけではなく保存的治療や経過観察も含めた内科・整形外科の連携体制がとられていることが望ましい.

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00697&link_issn=&doc_id=20230615020023&doc_link_id=%2Fae4digta%2F2023%2F011106%2F018%2F0823-0828%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae4digta%2F2023%2F011106%2F018%2F0823-0828%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

大規模言語モデル(ChatGPT)による医師国家試験解答解析

中原龍一, 西田圭一郎, 高橋康, 那須義久, 堀田佳史, 浪花崇一, 志水紀之, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 191 - 191 2023年6月

両手関節炎様の所見を呈した腱黄色腫の1例

浪花崇一, 志水紀之, 林徳てい, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 42 ( 3 ) 214 - 214 2023年6月

関節リウマチ患者に対する前足部切除関節形成術後の骨棘切除術

志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 249 - 249 2023年6月

J-SC人工肘関節の連結部に破損を生じた1例

那須義久, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 尾崎敏文

日本関節病学会誌 42 ( 3 ) 270 - 270 2023年6月

弾発指に対する術後リハビリテーションの有効性

斎藤太一, 中道亮, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 40 ( 1 ) O32 - 2 2023年4月

野球選手における有鉤骨骨折に対する皮皺に沿った掌側進入法における手術治療成績

島村安則, 根津智史, 斎藤太一, 中道亮, 山脇正, 久禮美穂, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 40 ( 1 ) O38 - 5 2023年4月

リウマチ手外科の原点と挑戦手関節に対する関節温存手術の適応と課題

那須義久, 西田圭一郎

日本手外科学会雑誌 40 ( 1 ) SY1 - 1 2023年4月

骨粗鬆症と骨代謝-3 ロモソズマブ治療の骨質に与える影響について

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 高杉幸司, 江澤和彦, 藤田慎一朗, 井上貴絵, 井上るみ, 山本渉, 新名早希子

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 648 - 648 2023年3月

関節リウマチ患者の骨粗鬆症に対するロモソズマブ治療の解析

高杉幸司, 原田遼三, 井上るみ, 井上貴絵, 藤田慎一朗, 山本渉, 新名早希子, 宮脇義亜, 松本佳則, 中原龍一, 西田圭一郎, 江澤和彦

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 882 - 882 2023年3月

生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

木曽洋平, 西田圭一郎, 原田遼三, 那須義久, 中原龍一, 渡辺雅仁, 堀田佳史, 浪花崇一, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S1022 - S1022 2023年3月

リウマチ性疾患における画像検査教師なしAIを用いたトポロジー学習・関節リウマチ超音波画像同一断面自動検出

中原龍一, 西田圭一郎, 那須義久, 浪花崇一, 堀田佳史, 志水紀之, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 718 - 718 2023年3月

リウマチ性疾患の手術:周術期管理・手術関連諸問題関節リウマチに対する整形外科手術後の手術部位感染・創傷治癒遅延の発生頻度と治癒過程はb/tsDMARD使用に影響されるか?

浪花崇一, 志水紀之, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 691 - 691 2023年3月

生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

木曽洋平, 西田圭一郎, 原田遼三, 那須義久, 中原龍一, 渡辺雅仁, 堀田佳史, 浪花崇一, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S1022 - S1022 2023年3月

人工肘関節置換術-合併症に対する創意と工夫- 人工肘関節周囲骨折の治療戦略

那須義久, 志水紀之, 浪花崇一, 堀田佳史, 原田遼三, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S565 - S565 2023年3月

関節リウマチ関節手術のフレイル脱却に対する効果

小嶋俊久, 浅井秀司, 石川肇, 田中栄, 橋本淳, 西田圭一郎, 寺部健哉, 鈴木望人, 服部陽介, 小嶋雅代, 今釜史郎

日本整形外科学会雑誌 97 ( 2 ) S57 - S57 2023年3月

在宅医療への治療移行における専門医,非専門医との連携課題と医療ソーシャルワーカー(MSW)の役割

新名早希子, 原田遼三, 高杉幸司, 山本渉, 藤田慎一朗, 井上貴絵, 井上るみ, 那須義久, 中原龍一, 西田圭一郎, 江澤和彦

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 805 - 805 2023年3月

人工肘関節置換術-合併症に対する創意と工夫- 人工肘関節周囲骨折の治療戦略

那須義久, 志水紀之, 浪花崇一, 堀田佳史, 原田遼三, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 97 ( 3 ) S565 - S565 2023年3月

Association of phase angle with sarcopenia in chronic musculoskeletal pain patients: a retrospective study. 査読国際誌

Hironori Tsuji, Tomoko Tetsunaga, Haruo Misawa, Keiichiro Nishida, Toshifumi Ozaki

Journal of orthopaedic surgery and research 18 ( 1 ) 87 - 87 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: In chronic musculoskeletal pain patients, detection of sarcopenia is of significant clinical interest. Phase angle, which can be measured through bioelectrical impedance analysis (BIA), can detect sarcopenia; however, the evidence in chronic musculoskeletal pain patients is limited. This study aimed to assess the relationship between phase angle and sarcopenia in patients with chronic musculoskeletal pain. Our hypothesis was that phase angle would be a useful indicator to identify sarcopenia in patients with chronic musculoskeletal pain. METHODS: A total of 190 patients (51 men and 139 women) with chronic musculoskeletal pain were included in this retrospective cross-sectional study. Patient data of backgrounds, numeric rating scale score for pain, skeletal muscle index, and phase angle assessed using BIA were retrospectively reviewed. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria 2019. RESULTS: A total of 51 patients (26.7%), including 10 men (19.6%) and 41 women (29.5%), were diagnosed with sarcopenia. Phase angle, sarcopenia-related factors, age, and body mass index (BMI) differed significantly in patients with and without sarcopenia. On multiple logistic regression analysis, the prevalence of sarcopenia was significantly correlated with phase angle and BMI. The areas under the curve exhibited high accuracy in discriminating sarcopenia in men and moderate accuracy in both sexes and in women. CONCLUSIONS: Phase angle may be a valid discriminator of sarcopenia in patients with chronic musculoskeletal pain.

DOI： 10.1186/s13018-023-03567-1

関節リウマチにおける手指関節・手関節の超音波パワードプラスコアと関節破壊の関連査読

Outcome of unlinked total elbow arthroplasty for rheumatoid arthritis in patients younger than 50 years old 査読

Keiichiro Nishida, Yoshihisa Nasu, Kenzo Hashizume, Shunji Okita, Ryuichi Nakahara, Taichi Saito, Toshifumi Ozaki, Hajime Inoue

Bone & Joint Open 4 ( 1 ) 19 - 26 2023年1月

沖田駿治, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 39 ( 4 ) 524 - 527 2023年1月

記述言語：日本語出版者・発行元：(一社)日本手外科学会

関節リウマチ患者において,関節超音波検査(以下US)で滑膜炎を認めた関節と関節破壊が進行する関節は必ずしも一致しないことが報告されている.USで評価を行った手指・手関節の関節破壊に対する予後を検討した.調査開始時にUSによるパワードプラ(以下PD)スコアの計測が行われ,調査開始時および調査開始後1年以上経過時に両手単純X線写真による関節破壊の進行が評価可能であった関節リウマチ患者70例を対象とした.多変量解析ではPDスコアの合計値のみが関節破壊の有意な危険因子として同定された(オッズ比1.19,P=0.010).両手のPDスコアの合計値は手関節の関節破壊(P=0.001)およびMCP関節の関節破壊(P<0.001)と相関を認めた.各関節のPDスコアは同関節の関節破壊と相関を認めた(P<0.001).諸家の報告と異なりUSで滑膜炎を認めた関節は関節破壊が進行しやすい結果であった.(著者抄録)

関節リウマチによる高度手関節変形に対して手関節全固定術あるいは人工手関節置換術を行った8例の術後経過

市川千夏, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文

関節の外科 50 ( 2 ) 122 - 122 2023年

関節リウマチ患者に対するSauve-Kapandji法の臨床成績の検討

志水紀之, 西田圭一郎, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文

関節の外科 50 ( 2 ) 121 - 121 2023年

関節リウマチ患者に対するSauve-Kapandji法の臨床成績の検討

志水紀之, 西田圭一郎, 市川千夏, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文

関節の外科 50 ( 2 ) 121 - 121 2023年

関節リウマチによる高度手関節変形に対して手関節全固定術あるいは人工手関節置換術を行った8例の術後経過

市川千夏, 西田圭一郎, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 尾崎敏文

関節の外科 50 ( 2 ) 122 - 122 2023年

Late-onset rheumatoid arthritis registry study, LORIS study: study protocol and design. 国際誌

Masayo Kojima, Yutaka Kawahito, Takahiko Sugihara, Toshihisa Kojima, Ryozo Harada, Shintaro Hirata, Motomu Hashimoto, Toshihiko Hidaka, Hajime Ishikawa, Hiromu Ito, Mitsumasa Kishimoto, Yuko Kaneko, Kazuo Matsui, Toshihiro Matsui, Isao Matsushita, Akio Morinobu, Keiichiro Nishida, Eiichi Tanaka, Asami Abe, Michinori Ishitoku, Shuji Asai, Takashi Kida, Akira Onishi, Satoshi Takanashi, Masayoshi Harigai

BMC rheumatology 6 ( 1 ) 90 - 90 2022年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Although drug treatment strategies for rheumatoid arthritis (RA) are relatively well established, there is a paucity of evidence on the treatment in older patients. The purpose of this study is to build a registry for late-onset RA (LORA), which is expected to increase rapidly worldwide. In addition, we aim to propose optimal treatment strategies according to the patient background including frailty, thereby contributing to improving the quality of treatment and daily living in patients with RA. METHODS/DESIGN: The LORIS (Late-onset Rheumatoid Arthritis Registry) Study is a prospective nation-wide multicenter observational study of patients with LORA. The inclusion criteria were patients aged ≥ 65 years at onset, meeting 2010 ACR/EULAR classification criteria for RA, and starting either any disease-modifying antirheumatic drugs (DMARDs) in a DMARD-naïve patient or the first biologic/targeted synthetic DMARDs during the study period. Enrollment was started on 11 January, 2022 and will be closed on 31 December, 2023. Patients will undergo a comprehensive baseline assessment including clinical data, medication, cognitive and physical function, psychosocial factors, and frailty. Data will be collected at baseline, Month 3, 6, 12, 18, 24, 36, and summarized descriptively. The factors associated with adverse events and achieving remission will be determined. DISCUSSION: A multi-disciplinary panel including patients, rheumatologists, and geriatric specialists will discuss the results and build a consensus regarding the treatment goals of LORA. We expect to provide a broad range of information for evidence-based shared decision making in the treatment of LORA. STUDY REGISTRATION: Registered at the UMIN registry (UMIN000046086) on 1 January 2022.

DOI： 10.1186/s41927-022-00322-7

尺骨突き上げ症候群に対する尺骨骨幹部短縮骨切り術と遠位部短縮骨切り術の治療成績の比較

齋藤太一, 中道亮, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 39 ( 3 ) 315 - 318 2022年12月

記述言語：日本語出版者・発行元：(一社)日本手外科学会

当院では以前より尺骨突き上げ症候群に対しては尺骨骨幹部での短縮骨切りを施行してきたが,近年皮膚切開量が短く,骨癒合が有利な尺骨遠位部での骨切りをおこなっている.今回骨切り部位別に治療成績を比較検討したので報告する.尺骨突き上げ症候群に対して骨切り術を行い,術後評価可能であった37例を対象とした.骨幹部骨切り症例は15例,遠位部骨切り症例は,22例含まれていた.これらの群に対して平均の骨癒合期間,握力,手関節可動域,DASH,Pain-VAS,および術後合併症をそれぞれ比較した.平均骨癒合期間は骨幹部骨切り群では3.3ヵ月,遠位部骨切り群では2.6ヵ月,術後1年経過時の握力については骨幹部,遠位部骨切り群それぞれ平均31.7kg,30.2kgであった.術後1年経過時の掌背屈可動域は骨幹部,遠位部骨切り群それぞれ150.0度,152.7度,回内外可動域は骨幹部,遠位部骨切り群それぞれ155.0度,170.1度であり,平均術後成績に有意差は認められなかった.DASHに関しては骨幹部骨切りでは23.9から20.1,遠位部骨切りでは33.3から9.9へと遠位部骨切りに関してのみ術後有意差をもって改善していた.またVASを用いた痛み評価では骨幹部骨切りでは7.2から1.0,遠位部骨切りでは5.8から1.2へとどちらの群も有意差をもって改善していた.(著者抄録)

Japanese version of Patient-Rated Elbow Evaluation is a useful outcome measure that potentially reflects hand function in patients with rheumatoid arthritis who underwent total elbow arthroplasty 査読国際誌

Five cases of atypical ulnar fractures associated with long-term bisphosphonate use: An anatomical and mechanical analysis using a finite element model

Shunji Okita, Taichi Saito, Norio Yamamoto, Yusuke Mochizuki, Ryuichi Nakahara, Yasunori Shimamura, Toshiyuki Kunisada, Keiichiro Nishida, Toshifumi Ozaki

Journal of Orthopaedic Science 2022年11月

Ryozo Harada, Keiichiro Nishida, Yoshiyuki Matsuyama, Kenzo Hashizume, Takuro Wada, Yoshihisa Nasu, Ryuichi Nakahara, Masahiro Horita, Masuo Senda, Toshifumi Ozaki

Modern Rheumatology 32 ( 6 ) 1041 - 1046 2022年10月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objectives

We examined the relationship between the Japanese version of Patient-Rated Elbow Evaluation (PREE-J) and other established subjective and objective outcome measures in Japanese patients with rheumatoid arthritis (RA) who underwent total elbow arthroplasty (TEA).

Materials and Methods

This study involved 46 elbows of 40 RA patients. We collected clinical data 1 year after surgery, including the PREE-J, the Mayo Elbow Performance Score (MEPS), Disability of the Arm, Shoulder, and Hand (DASH), and Hand20. The correlation and responsiveness to PREE-J were evaluated compared with other outcome measures preoperatively and postoperatively.

Results

Almost all outcome measures were improved significantly after surgery. Preoperative PREE-J was significantly correlated with preoperative DASH, Hand20, and MEPS. Interestingly, postoperative PREE-J did not correlate with postoperative MEPS. Multiple regression analyses revealed that preoperative grip strength [B = −0.09; 95% confidence interval (95% CI) −0.17 to −0.01, p = 0.03] and preoperative Hand20 (B = 0.31, 95% CI 0.03–0.58, p = 0.03) were significant factors that might influence the postoperative PREE-J.

Conclusions

The PREE-J was shown to correlate well with other preoperative outcome measures among the RA patients included in the current study. The postoperative PREE-J after TEA was influenced by the preoperative grip strength and function of the hand.

DOI： 10.1093/mr/roab100

両側の人工肘関節置換術術後に異所性骨化を生じた1例

その他リンク： https://academic.oup.com/mr/article-pdf/32/6/1041/46543404/roab100.pdf

慢性疼痛患者を対象とした集学的治療における活動能力の継時的推移の類型化に関する検討

太田晴之, 齋藤圭介, 原田和宏, 京極真, 鉄永倫子, 西田圭一郎, 千田益生

運動器理学療法学 2 ( Suppl. ) O - 28 2022年10月

運動器慢性疼痛患者において生理的インピーダンス法における位相角はサルコペニア検出に有用である

辻寛謙, 鉄永倫子, 鉄永智紀, 高尾真一郎, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 14 ( 4 ) S49 - S49 2022年10月

超音波検査におけるリスター結節の解剖学的形状の観察

松山宜之, 中原龍一, 那須義久, 堅山佳美, 濱田全紀, 西田圭一郎, 千田益生

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S563 - S563 2022年10月

志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 34 ( 3 ) 406 - 406 2022年10月

AIを用いた超音波画像同一断面自動保存機能の開発

中原龍一, 西田圭一郎, 那須義久, 堀田佳史, 浪花崇一, 尾崎敏文

中国・四国整形外科学会雑誌 34 ( 3 ) 375 - 375 2022年10月

水銀式握力計で使用する新たな握力カフの開発(第二報)

藤岡晃, 高木涼, 松岡玲衣, 鍋倉由佳, 小川加苗, 松山宜之, 岡佳純, 西田圭一郎, 岡久雄, 堅山佳美, 濱田全紀, 千田益生

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S468 - S468 2022年10月

生理的インピーダンス法におけるPhase angleは運動器慢性疼痛患者においてサルコペニア検出に有用である

辻寛謙, 三澤治夫, 鉄永智紀, 濱田全紀, 堅山佳美, 小田孔明, 西田圭一朗, 千田益生, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 59 ( 秋季特別号 ) S343 - S343 2022年10月

Factors influencing caregiver burden in chronic pain patients: A retrospective study 国際誌

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Yoshiaki Oda, Shinichiro Takao, Keiichiro Nishida, Toshifumi Ozaki

Medicine 101 ( 39 ) e30802 - e30802 2022年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Ovid Technologies (Wolters Kluwer Health)

Chronic pain coexists with disability, anxiety, depression, and sleep disturbances, which are factors of pain chronicity in the fear-avoidance model. Self-efficacy for managing pain plays a protective role against pain chronicity. For chronic pain sufferers, social support from caregivers is important. However, such caregivers face enormous physical and mental burdens. This study aimed to assess how self-efficacy and factors related to the fear-avoidance model affect caregiver burden. Participants were 135 chronic pain patients and their caregivers who visited our outpatient pain special clinic. In clinical assessments, numeric rating scale (NRS), pain catastrophizing scale (PCS), hospital anxiety and depression scale (HADS), Athens insomnia scale (AIS), pain disability assessment scale (PDAS), pain self-efficacy questionnaire (PSEQ) for the patients and Zarit Burden Interview (ZBI) for their caregivers were evaluated. Participants were divided into 2 groups (L group ZBI < 24 points and H group ZBI ≥ 24 points) and compared. Regression analyses were conducted to identify factors correlated with the ZBI scores. Compared to L group, H group showed significantly higher NRS and HADs depression scores, and lower PSEQ scores. In univariate regression analysis, ZBI scores were significantly correlated with NRS, PCS, HADS anxiety, HADS depression, PDAS and PSEQ. Multiple linear regression analysis revealed that ZBI scores were significantly correlated with PSEQ. The caregivers who perceived high caregiver burden had significantly higher patients' pain intensity, depression, and lower self-efficacy than those who perceived low caregiver burden. Caregiver burden correlated with the pain intensity, pain catastrophizing, anxiety, depression, disability, and self-efficacy of chronic pain patients. Among these factors, self-efficacy was the most negatively correlated with caregiver burden. Treatments focused on increasing self-efficacy for managing pain have the potential to reduce caregiver burden.

DOI： 10.1097/md.0000000000030802

DevOpsを用いた機械学習・医療アプリケーションの開発効率の改善

中原龍一, 西田圭一郎, 高橋康, 那須義久, 原田遼三, 堀田佳史, 浪花崇一, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1796 - S1796 2022年9月

慢性疼痛患者を対象とした集学的治療における活動能力の継時的推移の類型化に関する検討

太田晴之, 齋藤圭介, 原田和宏, 京極真, 鉄永倫子, 西田圭一郎, 千田益生

Journal of Musculoskeletal Pain Research 14 ( 3 ) 171 - 181 2022年9月

記述言語：日本語出版者・発行元：(一社)日本運動器疼痛学会

慢性疼痛患者における集学的治療が6ヵ月間可能であった集団の治療経過における継時的推移について,活動能力を指標に潜在プロフィール分析(Latent Profile Analysis:LPA)を用い集団を類型化すること,類型化された各集団の特徴について検討することである。結果,慢性疼痛患者において,活動能力の継時的推移は4つの集団に類型化できること,その治療経過は開始時の身体的パフォーマンスの状態で異なる治療経過を辿る可能性を明らかにした。(著者抄録)

DevOpsを用いた機械学習・医療アプリケーションの開発効率の改善

両側の人工肘関節置換術術後に異所性骨化を生じた1例

志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本関節病学会誌 41 ( 3 ) 165 - 165 2022年9月

中原龍一, 西田圭一郎, 高橋康, 那須義久, 原田遼三, 堀田佳史, 浪花崇一, 尾崎敏文

日本整形外科学会雑誌 96 ( 8 ) S1796 - S1796 2022年9月

関節リウマチにおけるMCP人工指関節再置換術の短期成績

浪花崇一, 堀田佳史, 志水紀之, 中原龍一, 那須義久, 尾崎敏文, 西田圭一郎

日本関節病学会誌 41 ( 3 ) 167 - 167 2022年9月

The effect of mechanical stress on enthesis homeostasis in a rat Achilles enthesis organ culture model 査読

Taichi Saito, Ryo Nakamichi, Aki Yoshida, Takaaki Hiranaka, Yuki Okazaki, Satoshi Nezu, Minami Matsuhashi, Yasunori Shimamura, Takayuki Furumatsu, Keiichiro Nishida, Toshifumi Ozaki

Journal of Orthopaedic Research 40 ( 8 ) 1872 - 1882 2022年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Wiley

Tendons and ligaments are jointed to bones via an enthesis that is essential to the proper function of the muscular and skeletal structures. The aim of the study is to investigate the effect of mechanical stress on the enthesis. We used ex vivo models in organ cultures of rat Achilles tendons with calcaneus including the enthesis. The organ was attached to a mechanical stretching apparatus that can conduct cyclic tensile strain. We made the models of 1-mm elongation (0.5 Hz, 3% elongation), 2-mm elongation (0.5 Hz, 5% elongation), and no stress. Histological evaluation by Safranin O staining and Toluidin Blue and Picro Sirius red staining was conducted. Expression of sex-determining region Y-box 9 (Sox9), scleraxis (Scx), Runt-related transcription factor 2 (Runx2), and matrix metalloproteinase 13 (Mmp13) were examined by real-time polymerase chain reaction and immunocytochemistry. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick end-labeling and live/dead staining and was conducted for evaluation of the apoptosis and cell viability. The structure of the enthesis was most maintained in the model of 1-mm elongation. The electronic microscope showed that the enthesis of the no stress model had ill-defined borders between fibrocartilage and mineralized fibrocartilage, and that calcification of mineralized fibrocartilage occurred in the model of 2-mm elongation. Sox9 and Scx was upregulated by 1-mm elongation, whereas Runx2 and Mmp13 were upregulated by 2-mm elongation. Apoptosis was inhibited by low stress. The results of this study suggested that 1-mm elongation can maintain the structure of the enthesis, while 2-mm elongation promotes degenerative changes.

DOI： 10.1002/jor.25210

その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jor.25210

Evaluation of SARC-F and SARC-CalF for sarcopenia screening in patients with chronic musculoskeletal pain: A prospective cross-sectional study. 国際誌

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Yoshiaki Oda, Shinichiro Takao, Keiichiro Nishida, Toshifumi Ozaki

Medicine 101 ( 29 ) e29568 2022年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Early sarcopenia detection using screening tools, such as SARC-F and SARC-CalF, has been proven reliable. However, the relationship between chronic musculoskeletal pain with sarcopenia is unknown. This study assessed sarcopenia morbidity as well as the reliability of sarcopenia screening with SARC-F and SARC-CalF in patients with chronic musculoskeletal pain. METHODS: Overall, 172 patients with chronic musculoskeletal pain were included in this cross-sectional study. All participants completed the SARC-F, SARC-CalF, numeric rating scale (NRS), and pain disability assessment scale (PDAS) assessments. Sarcopenia was diagnosed using the Asian Working Group for Sarcopenia criteria 2019. Correlations between SARC-F and SARC-CalF scores and each measured variable were evaluated using univariate and multiple linear regression analyses. A receiver operating characteristic curve analysis was conducted, and reliabilities of SARC-F and SARC-CalF scores for diagnosing sarcopenia were compared. RESULTS: Thirty-nine patients were diagnosed with sarcopenia. Among these, 10 patients were <65 years old, and 29 were >65 years old. Both SARC-F and SARC-CalF scores significantly correlated with grip power, gait speed, skeletal mass index, numeric rating scale score, and PDAS score. In multiple linear regression analysis, SALC-F and SALC-CalF scores significantly correlated with PDAS score, skeletal mass index, and gait speed. The area under the curve were 0.70 for SARC-F and 0.88 for SARC-CalF; SARC-CalF had a significantly higher area under the curve than SARC-F. DISCUSSION: Sarcopenia was diagnosed in patients aged <65 years with chronic musculoskeletal pain. SALC-F and SARC-CalF scores showed a significant correlation with disability due to pain and were reliable sarcopenia screening tools for chronic musculoskeletal pain. SARC-CalF was more reliable than SARC-F.

DOI： 10.1097/MD.0000000000029568

Safety and effectiveness of certolizumab pegol in Japanese patients with rheumatoid arthritis: Results from a 24-week post-marketing surveillance study 査読

Hideto Kameda, Keiichiro Nishida, Toshihiro Nanki, Akira Watanabe, Yukiya Oshima, Shigeki Momohara

Modern Rheumatology 33 ( 3 ) 460 - 471 2022年7月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objectives

To report 24-week safety and effectiveness of certolizumab pegol (CZP) in Japanese patients with rheumatoid arthritis from a post-marketing surveillance study.

Methods

Enrolled patients were newly receiving CZP. All adverse events (AEs) and adverse drug reactions (ADRs) were recorded for patients who received ≥1 CZP dose. Effectiveness outcomes included: 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR) and European Alliance of Associations for Rheumatology (EULAR) response. Missing data were imputed using the last observation carried forward.

Results

3727 patients were enrolled; safety and effectiveness were evaluated in 3586 and 1794 patients, respectively. 24.9% of patients reported AEs (893/3586), 14.7% reported ADRs (528/3586), 8.3% (298/3586) reported serious AEs and 5.3% (190/3586) reported serious ADRs. Selected serious ADRs of interest: infections (110; 3.1%), tuberculosis (6; 0.2%), interstitial pneumonia (15; 0.4%), malignancy (8; 0.2%), and hepatic function disorder (7; 0.2%). No allergic reactions, autoimmune disease, cardiac failure, demyelinating diseases, or pancytopenia were reported. Mean DAS28-ESR reduced from 4.8 (baseline) to 3.4 (final evaluation). At final evaluation, 34.7% of patients achieved EULAR good response.

Conclusions

These real-world safety and effectiveness results were consistent with previously reported data, with no new safety signals identified. Long-term, real-world CZP safety and effectiveness data are needed.

DOI： 10.1093/mr/roac073

Non-drug and surgical treatment algorithm and recommendations for the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis—secondary publication

その他リンク： https://academic.oup.com/mr/article-pdf/33/3/460/49879660/roac073.pdf

関節リウマチにおける手指関節・手関節の超音波パワードプラスコアと関節破壊の関連

沖田駿治, 中原龍一, 那須義久, 西田圭一郎

日本手外科学会雑誌 39 ( 1 ) O31 - 3 2022年4月

尺骨突き上げ症候群に対する尺骨骨幹部短縮骨切り術と遠位部短縮骨切り術の治療成績の比較

齋藤太一, 根津智史, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 39 ( 1 ) O66 - 5 2022年4月

Hiromu Ito, Keiichiro Nishida, Toshihisa Kojima, Isao Matsushita, Masayo Kojima, Shintaro Hirata, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Masaaki Mori, Akio Morinobu, Atsuko Murashima, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Takeo Nakayama, Hisashi Yamanaka, Yutaka Kawahito, Masayoshi Harigai

Modern Rheumatology 33 ( 1 ) 36 - 45 2022年3月

掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objectives

The aim of this study was to update the Japan College of Rheumatology (JCR) clinical practice guidelines (CPGs) for the management of rheumatoid arthritis (RA) and prepare an algorithm for non-drug and surgical treatments. This article is a digest version of the guidelines.

Methods

The Japanese Ministry of Health, Labour and Welfare’s research group, in collaboration with the JCR, used the Grading of Recommendations, Assessment, Development, and Evaluation method to update the 2014 JCR CPG for RA. The consensus was formed by CPG panel members.

Results

We raised 19 clinical questions regarding non-drug and surgical treatments for RA and developed recommendations. The treatments included exercise therapy; occupational therapy; joint injection of corticosteroids; and orthopaedic surgeries including cervical spine surgery, wrist and foot arthroplasty, ankle arthrodesis, and replacement arthroplasty of the shoulder, elbow, finger, hip, knee, and ankle. Recommendations regarding the risks of surgery and perioperative discontinuation of medications have also been developed. Based on these recommendations, we created an original algorithm for the non-drug and surgical treatment of RA.

Conclusions

These recommendations are expected to serve rheumatologists, health care professionals, and patients with RA as tools for shared decision-making to treat residual limb joint symptoms and functional impairment.

DOI： 10.1093/mr/roac019

Drug treatment algorithm and recommendations from the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis—secondary publication 査読

その他リンク： https://academic.oup.com/mr/article-pdf/33/1/36/48626507/roac019.pdf

Yutaka Kawahito, Akio Morinobu, Yuko Kaneko, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Hiromu Ito, Toshihisa Kojima, Isao Matsushita, Keiichiro Nishida, Masaaki Mori, Atsuko Murashima, Hisashi Yamanaka, Takeo Nakayama, Masayo Kojima, Masayoshi Harigai

Modern Rheumatology 33 ( 1 ) 21 - 35 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

ABSTRACT

Objective

The aim of this study was to update the Japan College of Rheumatology (JCR) clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA; JCR CPG for RA) according to recent changes in the medical environment in Japan. This article is a digest version of the guidance.

Methods

We used the Grading of Recommendations, Assessment, Development, and Evaluation method to update the 2014 JCR CPG for RA. A consensus was formed by CPG panel members.

Results

We identified 36 important clinical questions regarding drug treatment and developed corresponding recommendations for RA. The recommendations included the following RA medications: non-steroidal anti-inflammatory drugs, corticosteroids, conventional synthetic disease-modifying antirheumatic drugs, biological disease-modifying antirheumatic drugs, anti-receptor activator for nuclear factor-κB ligand antibodies, and Janus kinase inhibitors, as well as the tapering and discontinuation of these medications. Recommendations regarding the efficacy and safety of treatments in the elderly and patients with comorbidities were also developed. Finally, we used these recommendations to create an original algorithm for drug treatment for RA based on the Treat-to-Target approach.

Conclusion

The 2020 JCR CPG for RA provides a useful tool for rheumatologists, health care professionals, and patients with RA, enabling shared decision-making in a variety of clinical situations.

DOI： 10.1093/mr/roac017

リウマチ肘に対するPROSNAP人工肘関節置換術の短期成績

その他リンク： https://academic.oup.com/mr/article-pdf/33/1/21/49137216/roac017.pdf

リハビリテーション T2Tを実践した場合の1年間のSMIの推移

藤田慎一朗, 原田遼三, 高杉幸司, 江澤和彦, 井上貴絵, 井上るみ, 新名早希子, 山本渉, 中原龍一, 那須義久, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 405 - 405 2022年3月

リウマチ性疾患の上肢手術リウマチ母指に対する母指MCP人工関節置換術の長期成績

兼田大輔, 西田圭一郎, 那須義久, 中原龍一, 原田遼三, 渡辺雅仁, 堀田佳史, 浪花崇一

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 352 - 352 2022年3月

堀田佳史, 西田圭一郎, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S247 - S247 2022年3月

関節リウマチ患者に対する連結型人工肘関節全置換術(PROSNAP)の臨床成績の検討

堀田佳史, 西田圭一郎, 浪花崇一, 原田遼三, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 618 - 618 2022年3月

人工手関節置換術後のゆるみに対して他家骨移植を併用した全人工手関節固定術を施行した1例

那須義久, 西田圭一郎, 中原龍一, 浪花崇一, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 616 - 616 2022年3月

関節リウマチの増悪との鑑別に苦慮した両側踵脆弱性骨折の1例

氏家正皓, 片山祐, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 中土井崇人, 浅野洋介, 大橋敬司, 宮脇義亜, 勝山恵理, 勝山隆行, 楢崎真理子, 佐田憲映, 松本佳則, 中原龍一, 那須義久, 西田圭一郎, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 753 - 753 2022年3月

人工肘関節全置換術を施行した関節リウマチ患者の上肢機能に影響を与える因子の検討

松山宜之, 那須義久, 原田遼三, 中原龍一, 西田圭一郎, 尾崎敏文, 千田益生

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 636 - 636 2022年3月

リウマチ性疾患の上肢手術関節リウマチに対するAVANTAとINTEGRAを用いたMCP人工指関節置換術の術後可動域の比較

浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 353 - 353 2022年3月

関節リウマチにおける外科的治療の意義-機能障害の回復を目指して- RA患者に対する人工肘関節全置換術による機能回復

西田圭一郎, 松山宜之, 原田遼三, 那須義久, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 251 - 251 2022年3月

AIを用いた骨端線の年齢変化の学習と単純X線画像自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S427 - S427 2022年3月

関節リウマチ治療のパラダイムシフトに伴う上肢手術とリハビリテーション-変遷と展望- 人工肘関節全置換術後のリハビリテーションの変遷と展望

西田圭一郎, 松山宜之, 那須義久, 原田遼三, 中原龍一, 千田益生, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S413 - S413 2022年3月

その他の(多彩な)膠原病機械学習を用いたサマリー自動可視化システムによるサマリー記載の標準化

中原龍一, 西田圭一郎, 高橋康, 浪花崇一, 堀田佳史, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 477 - 477 2022年3月

腱骨接合部の恒常性におけるメカニカルストレスの影響

齋藤太一, 根津智史, 吉田晶, 島村安則, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S315 - S315 2022年3月

AIを用いた骨端線の年齢変化の学習と単純X線画像自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S427 - S427 2022年3月

関節リウマチの増悪との鑑別に苦慮した両側踵脆弱性骨折の1例

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 753 - 753 2022年3月

関節リウマチ治療のパラダイムシフトに伴う上肢手術とリハビリテーション-変遷と展望- 人工肘関節全置換術後のリハビリテーションの変遷と展望

西田圭一郎, 松山宜之, 那須義久, 原田遼三, 中原龍一, 千田益生, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S413 - S413 2022年3月

リウマチ肘に対するPROSNAP人工肘関節置換術の短期成績

堀田佳史, 西田圭一郎, 浪花崇一, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 96 ( 2 ) S247 - S247 2022年3月

リウマチ性疾患の上肢手術関節リウマチに対するAVANTAとINTEGRAを用いたMCP人工指関節置換術の術後可動域の比較

浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 353 - 353 2022年3月

関節リウマチにおける外科的治療の意義-機能障害の回復を目指して- RA患者に対する人工肘関節全置換術による機能回復

西田圭一郎, 松山宜之, 原田遼三, 那須義久, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 251 - 251 2022年3月

人工手関節置換術後のゆるみに対して他家骨移植を併用した全人工手関節固定術を施行した1例

那須義久, 西田圭一郎, 中原龍一, 浪花崇一, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 616 - 616 2022年3月

その他の(多彩な)膠原病機械学習を用いたサマリー自動可視化システムによるサマリー記載の標準化

中原龍一, 西田圭一郎, 高橋康, 浪花崇一, 堀田佳史, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 477 - 477 2022年3月

人工肘関節全置換術を施行した関節リウマチ患者の上肢機能に影響を与える因子の検討

松山宜之, 那須義久, 原田遼三, 中原龍一, 西田圭一郎, 尾崎敏文, 千田益生

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 636 - 636 2022年3月

関節リウマチ患者に対する連結型人工肘関節全置換術(PROSNAP)の臨床成績の検討

堀田佳史, 西田圭一郎, 浪花崇一, 原田遼三, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 618 - 618 2022年3月

フットケア外来を通じ手術治療機会を得た高齢RA患者の一例

井上るみ, 原田遼三, 高杉幸司, 江澤和彦, 井上貴絵, 藤田慎一朗, 新名早希子, 山本渉, 中原龍一, 那須義久, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 731 - 731 2022年3月

JAK阻害薬継続下にCOVID-19ワクチン接種を行った症例の経過について症例報告

原田遼三, 高杉幸司, 江澤和彦, 井上貴絵, 藤田慎一朗, 井上るみ, 新名早希子, 山本渉, 中原龍一, 那須義久, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 701 - 701 2022年3月

リウマチ患者に対する母指MCP人工関節置換術の長期成績

兼田大輔, 西田圭一郎, 那須義久, 中原龍一, 渡辺雅仁, 堀田佳史, 浪花崇一

日本整形外科学会雑誌 96 ( 2 ) S139 - S139 2022年3月

リウマチ性疾患の上肢手術リウマチ母指に対する母指MCP人工関節置換術の長期成績

兼田大輔, 西田圭一郎, 那須義久, 中原龍一, 原田遼三, 渡辺雅仁, 堀田佳史, 浪花崇一

日本リウマチ学会総会・学術集会プログラム・抄録集 66回 352 - 352 2022年3月

Comprehensive risk analysis of postoperative complications in patients with rheumatoid arthritis for the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis 国際誌

Hiromu Ito, Koichi Murata, Yasumori Sobue, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Yutaka Kawahito, Masayo Kojima, Shintaro Hirata, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Masaaki Mori, Akio Morinobu, Atsuko Murashima, Yohei Seto, Takahiko Sugihara, Eiichi Tanaka, Takeo Nakayama, Masayoshi Harigai

Modern Rheumatology 32 ( 2 ) 296 - 306 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

To examine the risk factors of surgical site infection (SSI), delayed wound healing, and death after orthopedic surgery in patients with rheumatoid arthritis (RA).

Methods

We identified articles indexed in the Cochrane Library, PubMed, and Japan Centra Revuo Medicina Web published from 2013 to 2019 and other articles. Articles fulfilling the predefined inclusion criteria were reviewed systematically and their quality was appraised according to the Grading of Recommendations Assessment, Development, and Evaluation system with some modifications.

Results

After inclusion and exclusion by full-text review, 29 articles were analyzed. Use of biological disease modifying antirheumatic drugs was a risk factor of SSI (risk ratio 1.66, 95% confidence interval 1.25–2.19), but not of delayed wound healing. RA itself was a risk factor of SSI, and oral glucocorticoid use was a risk factor of SSI in three of the four studies analyzed and of postoperative death. Age, male sex, comorbidities such as diabetes mellitus and chronic obstructive pulmonary disease, surgical factors such as foot/ankle and spine surgery and longer operative time were risk factors of those postoperative complications.

Conclusion

Patients with those factors should be dealt with appropriate cautions to strike a risk–benefit balance of orthopedic surgeries.

DOI： 10.1080/14397595.2021.1913824

Systematic review for the treatment of older rheumatoid arthritis patients informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis 国際誌

その他リンク： https://academic.oup.com/mr/article-pdf/32/2/296/42644947/1913824.pdf

Takahiko Sugihara, Yutaka Kawahito, Akio Morinobu, Yuko Kaneko, Yohei Seto, Toshihisa Kojima, Hiromu Ito, Masataka Kohno, Takeo Nakayama, Yasumori Sobue, Keiichiro Nishida, Isao Matsushita, Atsuko Murashima, Masaaki Mori, Eiichi Tanaka, Shintaro Hirata, Mitsumasa Kishimoto, Hisashi Yamanaka, Masayo Kojima, Masayoshi Harigai

Modern Rheumatology 32 ( 2 ) 313 - 322 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

To provide an evidence base for clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA) in older adults.

Methods

PubMed, Cochrane library, and Japan Centra Revuo Medicina databases were searched for articles published between 1990 and 2019. Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation system, with some modifications.

Results

Among 702 identified articles, there were 5 post-hoc analyses of randomized controlled trials and 10 observational studies. Meta-analysis of the former yielded a mean difference of the van der Heijde-modified total Sharp score of −2.79 (95% confidence interval [CI] − 3.74 to −1.84) for treatment with tumor necrosis factor inhibitors. The risk ratio (RR) for the American College of Rheumatology 50% response rate, and for serious adverse events was 2.83 (95%CI 1.90–4.21) and 1.32 (95%CI 0.53–3.31), respectively, for Janus kinase inhibitors. Meta-analysis of the observational studies yielded an RR for disease activity score-28 remission and serious infections of 0.76 (95%CI 0.64–0.91) and 1.92 (95%CI 1.31–2.81) for older-versus-younger patients receiving biological disease-modifying antirheumatic drugs, respectively.

Conclusion

This systematic review provides the necessary evidence for developing CPG for the management of RA in older adults.

DOI： 10.1080/14397595.2021.1912922

Patients’ perspectives of rheumatoid arthritis treatment: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines 国際誌

その他リンク： https://academic.oup.com/mr/article-pdf/32/2/313/42644941/1912922.pdf

Masayo Kojima, Mieko Hasegawa, Shintaro Hirata, Hiromu Ito, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Toshihisa Kojima, Isao Matsushita, Masaaki Mori, Akio Morinobu, Atsuko Murashima, Keiichiro Nishida, Yohei Seto, Yasumori Sobue, Takahiko Sugihara, Eiichi Tanaka, Takeo Nakayama, Yutaka Kawahito, Masayoshi Harigai

Modern Rheumatology 32 ( 2 ) 307 - 312 2022年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

This study aimed to evaluate patients’ opinions regarding their rheumatoid arthritis (RA) therapy and to reflect the patients’ perspectives in the 2020 update of the Japan College of Rheumatology clinical practice guidelines.

Methods

A self-administered questionnaire was mailed to 1600 members of the Japan Rheumatology Friendship Association, who were randomly selected by age and prefecture.

Results

A total of 1156 patients returned the questionnaire (response rate, 72.3%; mean age, 63.0 ± 11.9 years). Those who reported having discussed their treatment goals with their doctors (450 respondents, 38.9%) were more likely to be satisfied with their current medical care (odds ratio, 7.13; 95% CI 4.72–10.8) compared with those who had not discussed their goals nor had them explained (287 respondents, 24.8%). The benefits exceeded the adverse effects for all pharmacotherapy (methotrexate, corticosteroids, conventional synthetic antirheumatic drugs, biological agents, Janus kinase inhibitor, and anti-RANKL antibodies). However, while 74.2% of the respondents using biological agents perceived that ‘the favorable aspects outweighed the unfavorable aspects,’ most of those taking anti-RANKL antibodies (69.2%) felt uncertain.

Conclusions

The questionnaire successfully collected information regarding patients’ perceptions regarding their therapy. Further implementation of treat-to-target is necessary in Japan to improve patient satisfaction.

DOI： 10.1080/14397595.2021.1913276

CD30-targeted therapy induces apoptosis of inflammatory cytokine-stimulated synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice 査読国際誌

その他リンク： https://academic.oup.com/mr/article-pdf/32/2/307/42644853/1913276.pdf

Minami Matsuhashi, Keiichiro Nishida, Misa Sakamoto, Yuka Gion, Aki Yoshida, Takayuki Katsuyama, Ryuichi Nakahara, Yoshihisa Nasu, Yoshinori Matsumoto, Yasuharu Sato, Toshifumi Ozaki

Inflammation Research 71 ( 2 ) 215 - 226 2022年2月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

OBJECTIVE: It has been reported that levels of soluble CD30 in serum and joint fluid are significantly elevated in patients with rheumatoid arthritis (RA). This study aimed to investigate whether CD30 could be a therapeutic target for RA. METHODS: The expression and localization of CD30 were examined by immunohistochemical and double immunofluorescence staining on synovial tissue samples obtained from patients with RA or osteoarthritis (OA) during surgery. Changes in CD30 expression of fibroblast-like synoviocytes (FLS) from RA patients with or without TNFα and IL-1β stimulation were examined by the polymerase chain reaction (PCR) and flow cytometry. Collagen antibody-induced arthritis (CAIA) was created in DBA/1 mice, and the therapeutic effect of brentuximab vedotin (BV) was examined by clinical score, histological findings and measurement of serum levels of SAA, IL-6, and TNFα. RESULTS: CD30 expression was significantly higher in samples from patients with RA than from those with OA. Double immunofluorescence showed a low rate of co-localization of CD30 with CD20 or CD90, but a high rate of co-localization of CD30 and CD138. CD30 mRNA expression was upregulated 11.7-fold in FLS following stimulation by inflammatory cytokines. The clinical scores of CAIA mice were significantly lower following both BV treatments, however, the histological scores of CAIA mice were significantly lower only following treatment with high dose BV (70 mg/kg). CONCLUSIONS: CD30 was expressed on immunocompetent cells in synovial tissue from RA patients and in cytokine-stimulated FLS in vitro. High dose BV (70 mg/kg) showed significant therapeutic effects in ameliorating inflammation and joint destruction in CAIA mice, but low dose BV (30 mg/kg) was insufficient.

DOI： 10.1007/s00011-021-01537-z

Patient satisfaction with total joint replacement surgery for rheumatoid arthritis: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines 国際誌

その他リンク： https://link.springer.com/article/10.1007/s00011-021-01537-z/fulltext.html

Yasumori Sobue, Masayo Kojima, Toshihisa Kojima, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Shintaro Hirata, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Atsuko Murashima, Akio Morinobu, Masaaki Mori, Takeo Nakayama, Takahiko Sugihara, Yohei Seto, Eiichi Tanaka, Mieko Hasegawa, Yutaka Kawahito, Masayoshi Harigai

Modern Rheumatology 32 ( 1 ) 121 - 126 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objective

This study aimed to evaluate satisfaction with total joint replacement (TJR) surgery among patients with rheumatoid arthritis (RA).

Methods

We mailed questionnaires to randomly selected members of the Japan Rheumatism Friendship Association, stratified by age and prefecture, throughout Japan. The questionnaire collected demographic and clinical characteristics as well as patients’ satisfaction with TJR and their current therapy.

Results

Of the 1156 patients who returned the questionnaire, 339 (29.3%) responded that they had had TJR of any type. The mean age was 66.6 years, and 94.4% were women. The mean time period from the hip and knee TJR was 14–15 years. Over half of the patients who had had TJR were satisfied with the results, especially those who had had hip (89.6%) and knee TJR (87.3%), who reported a high level of satisfaction. Multivariable linear regression analysis revealed that, in patients with knee TJR, satisfaction with current therapy was significantly related to whether they were satisfied with the results of the surgery.

Conclusion

Most patients with RA who had undergone TJR were satisfied with the results even after a long period of time, and their level of satisfaction was associated with their satisfaction with current therapy.

DOI： 10.1080/14397595.2021.1892258

Systematic review and meta-analysis of biosimilar for the treatment of rheumatoid arthritis informing the 2020 update of the Japan College of Rheumatology clinical practice guidelines for the management of rheumatoid arthritis 国際誌

その他リンク： https://academic.oup.com/mr/article-pdf/32/1/121/42083431/1892258.pdf

Eiichi Tanaka, Yutaka Kawahito, Masataka Kohno, Shintaro Hirata, Mitsumasa Kishimoto, Yuko Kaneko, Hiroya Tamai, Yohei Seto, Akio Morinobu, Takahiko Sugihara, Atsuko Murashima, Masayo Kojima, Masaaki Mori, Hiromu Ito, Toshihisa Kojima, Yasumori Sobue, Keiichiro Nishida, Isao Matsushita, Takeo Nakayama, Hisashi Yamanaka, Masayoshi Harigai

Modern Rheumatology 32 ( 1 ) 74 - 86 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

To evaluate the efficacy and safety of biosimilars compared with reference biological disease modifying antirheumatic drugs (bDMARDs) in patients with rheumatoid arthritis (RA) as a part of the process of developing the 2020 update of the Japan College of Rheumatology guidelines for the management of RA.

Methods

PubMed, Cochrane Library, and Japan Centra Revuo Medicina were searched for articles to conduct a systematic review (SR). The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation system.

Results

Twenty randomized controlled trials were included (biosimilars of infliximab, etanercept, and adalimumab). A meta-analysis revealed that the risk ratios (RRs) and 95% confidence intervals (CIs) of achieving the American College of Rheumatology 50% response (ACR50) at week 24 and serious adverse events (SAEs) for biosimilars compared with the reference bDMARDs were 1.04 (0.98–1.10) and 0.84 (0.61–1.18), respectively. The RRs of achieving ACR50 and SAEs at week 24 were respectively 0.93 (0.69–1.26) and 2.15 (0.55–8.35) in the patients who switched to biosimilars from the reference bDMARDs and 0.92 (0.76–1.12) and 1.41 (0.32–6.15) in those who continued the reference bDMARDs.

Conclusion

Biosimilars and reference bDMARDs were equally useful for the management of RA.

DOI： 10.1080/14397595.2021.1899591

Does exercise therapy improve patient-reported outcomes in rheumatoid arthritis? A systematic review and meta-analysis for the update of the 2020 JCR guidelines for the management of rheumatoid arthritis 国際誌

その他リンク： https://academic.oup.com/mr/article-pdf/32/1/74/42083415/1899591.pdf

Yasumori Sobue, Toshihisa Kojima, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Yuko Kaneko, Mitsumasa Kishimoto, Masataka Kohno, Takahiko Sugihara, Yohei Seto, Eiichi Tanaka, Takeo Nakayama, Shintaro Hirata, Atsuko Murashima, Akio Morinobu, Masaaki Mori, Masayo Kojima, Yutaka Kawahito, Masayoshi Harigai

Modern Rheumatology 32 ( 1 ) 96 - 104 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Abstract

Objectives

This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system.

Methods

We searched PubMed, Japana Centra Revuo Medicina Web, and the Cochrane Library (from 2009 to 2018) to identify articles that evaluated PROs of exercise therapy and RA disease activity.

Results

A total of 662 articles were identified, including nine RCTs, and meta-analyses were performed on six RCTs on systemic exercise therapy and three RCTs on upper extremity exercise therapy. Analyzed exercise therapies were diverse, differing in target population, intervention method, and duration. Significant improvements were observed in the Health Assessment Questionnaire Disability Index (mean difference −0.35, 95% confidence interval (CI): −0.60 to −0.10), pain (standardized mean difference −2.04, 95% CI: −3.77 to −0.32), and SF-36. For upper extremity exercise therapy, significant improvements in PROs (Disabilities of the Arm, Shoulder, and Hand Questionnaire, Michigan Hand Outcome Questionnaire) were observed.

Conclusion

Exercise therapy in RA treatment improves patient subjective assessment of pain, physical function, and quality of life.

DOI： 10.1080/14397595.2021.1886653

その他リンク： https://academic.oup.com/mr/article-pdf/32/1/96/42083491/1886653.pdf

Subjective and Objective Outcomes of Surgery for Rheumatoid Forefoot Deformities Under the Current Treatment Paradigm 国際誌

Masahiro Horita, Keiichiro Nishida, Daisuke Kaneda, Kenzo Hashizume, Yoshihisa Nasu, Ryuichi Nakahara, Kenta Saiga, Hideki Ohashi, Masahito Watanabe, Toshifumi Ozaki

The Journal of Foot and Ankle Surgery 61 ( 1 ) 53 - 59 2022年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

We investigated the clinical outcomes of surgical procedures for the treatment of forefoot deformities in patients with rheumatoid arthritis. Twenty feet in 16 women (mean age 62.1 years) underwent corrective osteotomy of the first metatarsal bone with shortening oblique osteotomy of the lesser metatarsophalangeal joints (joint-preservation group), while 13 feet in 12 women (mean age 67.4 years) underwent arthrodesis of the first metatarsophalangeal joint with resection arthroplasty of the lesser metatarsophalangeal joints (joint-sacrifice group); mean follow-up for each group was 25.8 and 23.8 months, respectively. The mean total Japanese Society for Surgery of the Foot (JSSF) scale improved significantly from 64.2 to 89.2 in the joint-preservation group (p < .001), and from 54.2 to 74.2 in the joint-sacrifice group (p = .003). In the joint-preservation group, the postoperative range of motion (ROM) of the joint, walking ability, and activities of daily living scores of the JSSF scale were significantly higher than those in the joint-sacrifice group (p = .001, p = .001, and p = .019, respectively). There were no differences in the subscale scores of the self-administered foot evaluation questionnaire between 2 groups either pre- or postoperatively. No differences in the postoperative complications were found between 2 groups. Although the joint-sacrificing procedure resulted in lower objective outcomes than the joint-preserving procedure regarding the ROM of the joint, the walking ability, and the level of activities of daily living, both procedures resulted in similar treatment outcomes when evaluated by the subjective measures.

DOI： 10.1053/j.jfas.2021.06.008

Outcome after resection arthroplasty or shortening oblique osteotomy of the lesser metatarsals combined with arthrodesis of the first metatarsophalangeal joint for severe rheumatoid forefoot deformities 査読国際誌

Masahiro Horita, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Kenta Saiga, Masanori Hamada, Toshifumi Ozaki

Journal of Orthopaedic Surgery 30 ( 2 ) 102255362211179 - 102255362211179 2022年1月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications

Purpose

We investigated objective and patient-reported outcomes after resection arthroplasty or shortening oblique osteotomy (SOO) of the lesser metatarsals combined with arthrodesis of the first metatarsophalangeal (MTP) joint for severe rheumatoid forefoot deformities.

Methods

17 feet from 14 women (mean age, 67.8 years) underwent resection arthroplasty of the lesser metatarsal heads (MTH resection group), while 13 feet from nine women and two men (mean age, 68.7 years) underwent SOO of the lesser metatarsals (MTH preservation group). Arthrodesis of the first MTP joint was performed in all cases. Mean follow-up in the MTH resection and preservation groups was 25.0 and 21.3 months, respectively. Preoperative and postoperative clinical evaluation included Japanese Society for Surgery of the Foot (JSSF) scale and self-administered foot evaluation questionnaire (SAFE-Q) scores.

Results

Mean total JSSF scale significantly improved from 53.4 to 76.4 in the MTH resection group ( p < .001) and from 50.1 to 74.2 in the MTH preservation group ( p = .002). Pain and pain-related and shoe-related SAFE-Q subscale scores significantly improved after surgery in both groups. In the MTH resection group, recurrence of painful callosities and claw toe deformity was observed in four and three feet, respectively. In the MTH preservation group, one patient experienced recurrence of painful callosities and one underwent revision surgery for IP joint dislocation.

Conclusion

Resection arthroplasty or SOO of the lesser metatarsals combined with arthrodesis of the first MTP joint achieved significant improvement with respect to pain relief, deformity correction, and footwear comfort.

DOI： 10.1177/10225536221117903

その他リンク： http://journals.sagepub.com/doi/full-xml/10.1177/10225536221117903

上腕筋三頭筋温存アプローチ用いてPROSNAP人工肘関節置換術を施行した症例

堀田佳史, 西田圭一郎, 志水紀之, 中原龍一, 那須義久, 尾崎敏文

関節の外科 49 ( 2 ) 106 - 106 2022年

生物学的製剤の使用は手術部位感染と創傷治癒遅延のリスク因子となるか

木曽洋平, 西田圭一郎, 原田遼三, 那須義久, 中原龍一, 堀田佳史, 浪花崇一, 尾崎敏文

関節の外科 49 ( 2 ) 59 - 59 2022年

バリシチニブ内服中の関節リウマチ患者が骨折術後に白血球減少を生じた一例

志水紀之, 西田圭一郎, 浪花崇一, 堀田佳史, 中原龍一, 那須義久

関節の外科 49 ( 2 ) 93 - 93 2022年

関節リウマチとして加療後、掌蹠膿疱症性骨関節炎と診断した1例の関節鏡視所見

那須義久, 志水紀之, 浪花崇一, 堀田佳史, 中原龍一, 西田圭一郎

関節の外科 49 ( 2 ) 94 - 94 2022年

Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis 査読国際共著国際誌

Yoshiaki Ito, Tokio Matsuzaki, Fumiaki Ayabe, Sho Mokuda, Ryota Kurimoto, Takahide Matsushima, Yusuke Tabata, Maiko Inotsume, Hiroki Tsutsumi, Lin Liu, Masahiro Shinohara, Yoko Tanaka, Ryo Nakamichi, Keiichiro Nishida, Martin K. Lotz, Hiroshi Asahara

Nature Communications 12 ( 1 ) 4148 - 4148 2021年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

<title>Abstract</title>Osteoarthritis (OA), the most common aging-related joint disease, is caused by an imbalance between extracellular matrix synthesis and degradation. Here, we discover that both strands of microRNA-455 (miR-455), -5p and -3p, are up-regulated by Sox9, an essential transcription factor for cartilage differentiation and function. Both miR-455-5p and -3p are highly expressed in human chondrocytes from normal articular cartilage and in mouse primary chondrocytes. We generate miR-455 knockout mice, and find that cartilage degeneration mimicking OA and elevated expression of cartilage degeneration-related genes are observed at 6-months-old. Using a cell-based miRNA target screening system, we identify hypoxia-inducible factor-2α (HIF-2α), a catabolic factor for cartilage homeostasis, as a direct target of both miR-455-5p and -3p. In addition, overexpression of both miR-455-5p and -3p protect cartilage degeneration in a mouse OA model, demonstrating their potential therapeutic value. Furthermore, knockdown of HIF-2α in 6-month-old miR-455 knockout cartilage rescues the elevated expression of cartilage degeneration-related genes. These data demonstrate that both strands of a miRNA target the same gene to regulate articular cartilage homeostasis.

DOI： 10.1038/s41467-021-24460-7

その他リンク： http://www.nature.com/articles/s41467-021-24460-7

骨粗鬆症性椎体骨折に対する骨折リエゾンサービスー骨粗鬆症マネージャーが果たす役割―

鉄永倫子, 鉄永智紀, 高尾真一郎, 小橋靖子, 西田圭一郎

整形外科最小侵襲手術ジャーナル 101 2021年12月

股関節痛を契機に診断された強直性脊椎炎の1例

山田和希, 那須義久, 鉄永智紀, 佐藤嘉洋, 廣瀬一樹, 中原龍一, 西田圭一郎, 尾崎敏文

日本小児整形外科学会雑誌 30 ( 2 ) 166 - 170 2021年12月

記述言語：日本語出版者・発行元：(一社)日本小児整形外科学会

股関節痛を契機に診断に至った、強直性脊椎炎:ankylosing spondylitis(以下、AS)の1例を経験したので報告する。症例は16歳男子で、右股関節痛のため近医を受診した。大腿骨寛骨臼インピンジメントの診断で当科に紹介された。当科初診時、右股関節痛は安静時と夜間に強く、運動時には感じなかった。右股関節の可動域制限を認め疼痛誘発テストは陽性であった。詳細に問診したところ、過去に腰臀部痛と両股関節痛を繰り返していた。単純X線では左仙腸関節に硬化像を認め、MRIでは右股関節水腫と両仙腸関節周囲の骨髄浮腫像を認めた。血液検査では炎症反応が上昇し、HLA-B27は陽性であった。ASと診断し、疾患活動性が高かったため、Infliximabの適応とした。治療は奏効し、現在も継続している。詳細な病歴聴取により早期の診断と治療が行えたため、短期の成績ではあるが経過良好であった。(著者抄録)

Difficult-to-treat RA の定義，臨床的特徴とマネジメント

西田圭一郎, 堀田佳史, 浪花崇一, 那須義久

臨床リウマチ 33 ( 4 ) 271 - 277 2021年12月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(一社)日本臨床リウマチ学会

治療が困難なRA(Difficult t-to-treat rheumatoid arthritis;D2T RA)とは、数種類の治療を行っても症状が改善せず、患者および経済的負担が大きいRA患者を指す新しい概念である。欧州リウマチ学会議(EULAR)では(1)治療不成功の病歴があり、(2)活動性/症候性の特性を有し、(3)臨床的に認識されていること、の3つの基準がすべて揃うものをD2T RAとした。D2T RAはRA患者の5～10%程度に発生するという報告が多く、患者は社会生活、労働能力、QOLに直接影響する症状に悩まされ続ける他、年間にかかる医療コストが非D2T RA患者より高額である。臨床的背景として、呼吸器障害、心血管系障害などの合併症、薬剤に対する有害事象、治療に対するアドヒアランスの低さの他、線維筋痛症や変形性関節症なとの疼痛症候群の合併、喫煙、肥満、抑うつなどが報告されている。治療にあたっては、患者教育、運動療法、心理学的介入、患者ケアの強化や医療従事者とのコミュニケーションの強化を基本として、個々の患者において過去の薬剤歴やmode of actionを考慮した薬剤選択や、整形外科的介入などによるカスタマイズを行って治療の最適化を図る必要がある。(著者抄録)

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2021&ichushi_jid=J02269&link_issn=&doc_id=20220204090002&doc_link_id=10.14961%2Fcra.33.271&url=https%3A%2F%2Fdoi.org%2F10.14961%2Fcra.33.271&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

周術期の投薬コントロールと合併症対策特集:関節リウマチ診療ガイドライン2020 ―整形外科医から見るガイドラインアップデート ― 査読

西田圭一郎, 中原龍一, 那須義久, 原田遼三

Loco Cure 7 ( 4 ) 314 - 318 2021年11月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(株)先端医学社

人工関節感染の有意なリスク因子として、BMI、DM、ステロイド、低アルブミン、関節リウマチ(RA)、輸血、悪性腫瘍、免疫低下、手術時間の延長、過去の手術歴などが指摘されており、疾患活動性のコントロールを含めて術前に可能な限り改善しせめて手術に臨むべきである。抗リウマチ薬には免疫抑制効果の懸念があり、長期の休薬はRAの再燃を惹起する可能性があるため、周術期の薬剤マネジメントが重要である。メトトレキサート(MTX)については、わが国のガイドラインでは12.5mg/週以下の使用量であれば再燃のリスクを抑制し、術後感染症、創傷治癒遅延に影響しないとされているため、休薬の必要はない。生物学的製剤、JAK阻害薬は免疫抑制作用によってSSIのリスクを増大させる可能性があるが、現時点では休薬期間を設けることによって安全に整形外科手術が可能である。(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J06622&link_issn=&doc_id=20211203480007&doc_link_id=%2Fae6locoe%2F2021%2F000704%2F008%2F0314-0318%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae6locoe%2F2021%2F000704%2F008%2F0314-0318%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

関節リウマチに対するAVANTAとINTEGRAを用いたMP人工指関節置換術の術後可動域の比較

浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎

日本関節病学会誌 40 ( 3 ) 304 - 304 2021年11月

AIを用いた単純X線画像における骨端線変化の自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本関節病学会誌 40 ( 3 ) 308 - 308 2021年11月

AIを用いた単純X線画像における骨端線変化の自動生成

中原龍一, 西田圭一郎, 長谷井嬢, 中澤慎二, 韓昌煕, 藏品豊, 那須義久, 尾崎敏文

日本関節病学会誌 40 ( 3 ) 308 - 308 2021年11月

関節リウマチに対するAVANTAとINTEGRAを用いたMP人工指関節置換術の術後可動域の比較

浪花崇一, 堀田佳史, 中原龍一, 那須義久, 西田圭一郎

日本関節病学会誌 40 ( 3 ) 304 - 304 2021年11月

Adipose-Derived Extract Suppresses IL-1β-Induced Inflammatory Signaling Pathways in Human Chondrocytes and Ameliorates the Cartilage Destruction of Experimental Osteoarthritis in Rats 査読国際誌

Hideki Ohashi, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Yoshinori Matsumoto, Ayumu Takeshita, Daisuke Kaneda, Masanori Saeki, Toshifumi Ozaki

International Journal of Molecular Sciences 22 ( 18 ) 9781 - 9781 2021年9月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MDPI AG

We investigated the effects of adipose-derived extract (AE) on cultured chondrocytes and in vivo cartilage destruction. AE was prepared from human adipose tissues using a nonenzymatic approach. Cultured human chondrocytes were stimulated with interleukin-1 beta (IL-1β) with or without different concentrations of AE. The effects of co-treatment with AE on intracellular signaling pathways and their downstream gene and protein expressions were examined using real-time PCR, Western blotting, and immunofluorescence staining. Rat AE prepared from inguinal adipose tissues was intra-articularly delivered to the knee joints of rats with experimental osteoarthritis (OA), and the effect of AE on cartilage destruction was evaluated histologically. In vitro, co-treatment with IL-1β combined with AE reduced activation of the p38 and ERK mitogen-activated protein kinase (MAPK) pathway and nuclear translocation of the p65 subunit of nuclear factor-kappa B (NF-κB), and subsequently downregulated the expressions of matrix metalloproteinase (MMP)-1, MMP-3, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, IL-6, and IL-8, whereas it markedly upregulated the expression of IL-1 receptor type 2 (IL-1R2) in chondrocytes. Intra-articular injection of homologous AE significantly ameliorated cartilage destruction six weeks postoperatively in the rat OA model. These results suggested that AE may exert a chondroprotective effect, at least in part, through modulation of the IL-1β-induced inflammatory signaling pathway by upregulation of IL-1R2 expression.

DOI： 10.3390/ijms22189781

日本人関節リウマチ患者におけるボディイメージ・アセスメントツールの信頼性の検討

小橋靖子, 西田圭一郎, 堀田昌宏, 那須義久, 原田遼三, 渡辺美紀, 菊地真佑花, 片上香里, 中原龍一, 尾﨑敏文

臨床リウマチ 33 ( 3 ) 221 - 232 2021年9月

記述言語：日本語出版者・発行元：(一社)日本臨床リウマチ学会

【目的】関節リウマチ(RA)患者におけるボディイメージ・アセスメントツール(BIAT)の信頼性と有効性を検証すること。【方法】本研究は横断的観察研究である。外来通院中(非手術群)および入院中(手術群)のRA患者265例および健常人62名を対象にBIAT質問用紙への回答を依頼した。信頼性の評価として、内部一貫法にはRA患者265例のbaselineのデータを、再テスト法には健常群62名のbaseline・3週後、および非手術群76例のbaseline・半年・1年後のデータを用いた。既存の評価法としてBDI-II(Beck Depression Inventory-II、ベック抑うつ質問票)を用いてBIATの臨床評価としての妥当性を検討した。RA患者265例をDAS28-CRPに基づき、寛解、低疾患活動性、中疾患活動性、高疾患活動性に群別し、BIATとの関連を検討した。さらに非手術群と手術群でBIATに差があるかどうかを検討した。【結果】BIATは全体の評価でも各構成概念の評価でもα係数は0.8以上を示しており、高い一貫性を有していた。再テスト法ではBIAT全体平均において、健常群のbaselineと3週後で相関係数0.75、非手術群のbaselineと半年後および1年後で相関係数0.79および0.78であり、比較的高い信頼性が確認できた。BIAT全体スコアはBDI-IIと有意な負の相関(r=-0.64、P<0.001)を示した。BIATは疾患活動性が高いほど低値となる傾向があることが示された。手術群でのbaselineの平均BIATの値はいずれの構成概念においても非手術群よりも有意に低値であった。【結論】RA患者に対するBIATは、高い一貫性、安定性を有する評価ツールであることが確認された。(著者抄録)

Modern rheumatology 32 ( 2 ) 1 - 11 2021年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To examine the risk factors of surgical site infection (SSI), delayed wound healing, and death after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS: We identified articles indexed in the Cochrane Library, PubMed, and Japan Centra Revuo Medicina Web published from 2013 to 2019 and other articles. Articles fulfilling the predefined inclusion criteria were reviewed systematically and their quality was appraised according to the Grading of Recommendations Assessment, Development, and Evaluation system with some modifications. RESULTS: After inclusion and exclusion by full-text review, 29 articles were analyzed. Use of biological disease modifying antirheumatic drugs was a risk factor of SSI (risk ratio 1.66, 95% confidence interval 1.25-2.19), but not of delayed wound healing. RA itself was a risk factor of SSI, and oral glucocorticoid use was a risk factor of SSI in three of the four studies analyzed and of postoperative death. Age, male sex, comorbidities such as diabetes mellitus and chronic obstructive pulmonary disease, surgical factors such as foot/ankle and spine surgery and longer operative time were risk factors of those postoperative complications. CONCLUSION: Patients with those factors should be dealt with appropriate cautions to strike a risk-benefit balance of orthopedic surgeries.

DOI： 10.1080/14397595.2021.1913824

教師なし学習を用いたAIによる超音波画像撮像部位自動検出

中原龍一, 高橋康, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 品岡玲, 尾崎敏文

日本整形外科学会雑誌 95 ( 8 ) S1726 - S1726 2021年8月

A Novel Radiographic Measurement Method for the Evaluation of Metatarsophalangeal Joint Dislocation of the Lesser Toe in Patients with Rheumatoid Arthritis. 国際誌

Hideki Ohashi, Keiichiro Nishida, Yoshihisa Nasu, Kenta Saiga, Ryuichi Nakahara, Masahiro Horita, Shunji Okita, Toshifumi Ozaki

International journal of environmental research and public health 18 ( 14 ) 2021年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Dorsal dislocation of metatarsophalangeal (MTP) joints of the lesser toe frequently occurs in patients with rheumatoid arthritis (RA), and may cause painful and uncomfortable plantar callosities and ulceration. The current study examined the reliability and clinical relevance of a novel radiographic parameter (the MTP overlap distance [MOD]) in evaluating the severity of MTP joint dislocation. The subjects of the current study were 147 RA patients (276 feet; 1104 toes). MOD, defined as the overlap distance of the metatarsal head and the proximal end of the phalanx, was measured on plain radiographs. The relationship between the MOD and clinical complaints (forefoot pain and/or callosity formation) was analyzed to create a severity grading system. As a result, toes with callosities had a significantly larger MOD. ROC analysis revealed that the MOD had a high AUC for predicting an asymptomatic foot (-0.70) and callosities (0.89). MOD grades were defined as follows: grade 1, 0 ≤ MOD < 5 mm; grade 2, 5 ≤ MOD < 10 mm; and grade 3, MOD ≥ 10 mm. The intra- and inter-observer reliability of the MOD grade had high reproducibility. Furthermore, the MOD and MOD grade improved significantly after joint-preserving surgeries for lesser toe deformities. Our results suggest that MOD and MOD grade might be useful tools for the evaluation of deformities of the lesser toe and the effect of surgical intervention for MTP joints in patients with RA.

DOI： 10.3390/ijerph18147520

Patients' perspectives of rheumatoid arthritis treatment: a questionnaire survey for the 2020 update of the Japan college of rheumatology clinical practice guidelines. 国際誌

Modern rheumatology 32 ( 2 ) 1 - 6 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: This study aimed to evaluate patients' opinions regarding their rheumatoid arthritis (RA) therapy and to reflect the patients' perspectives in the 2020 update of the Japan College of Rheumatology clinical practice guidelines. METHODS: A self-administered questionnaire was mailed to 1600 members of the Japan Rheumatology Friendship Association, who were randomly selected by age and prefecture. RESULTS: A total of 1156 patients returned the questionnaire (response rate, 72.3%; mean age, 63.0 ± 11.9 years). Those who reported having discussed their treatment goals with their doctors (450 respondents, 38.9%) were more likely to be satisfied with their current medical care (odds ratio, 7.13; 95% CI 4.72-10.8) compared with those who had not discussed their goals nor had them explained (287 respondents, 24.8%). The benefits exceeded the adverse effects for all pharmacotherapy (methotrexate, corticosteroids, conventional synthetic antirheumatic drugs, biological agents, Janus kinase inhibitor, and anti-RANKL antibodies). However, while 74.2% of the respondents using biological agents perceived that 'the favorable aspects outweighed the unfavorable aspects,' most of those taking anti-RANKL antibodies (69.2%) felt uncertain. CONCLUSIONS: The questionnaire successfully collected information regarding patients' perceptions regarding their therapy. Further implementation of treat-to-target is necessary in Japan to improve patient satisfaction.

DOI： 10.1080/14397595.2021.1913276

Modern rheumatology 32 ( 2 ) 1 - 15 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To provide an evidence base for clinical practice guidelines (CPG) for the management of rheumatoid arthritis (RA) in older adults. METHODS: PubMed, Cochrane library, and Japan Centra Revuo Medicina databases were searched for articles published between 1990 and 2019. Quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation system, with some modifications. RESULTS: Among 702 identified articles, there were 5 post-hoc analyses of randomized controlled trials and 10 observational studies. Meta-analysis of the former yielded a mean difference of the van der Heijde-modified total Sharp score of -2.79 (95% confidence interval [CI] - 3.74 to -1.84) for treatment with tumor necrosis factor inhibitors. The risk ratio (RR) for the American College of Rheumatology 50% response rate, and for serious adverse events was 2.83 (95%CI 1.90-4.21) and 1.32 (95%CI 0.53-3.31), respectively, for Janus kinase inhibitors. Meta-analysis of the observational studies yielded an RR for disease activity score-28 remission and serious infections of 0.76 (95%CI 0.64-0.91) and 1.92 (95%CI 1.31-2.81) for older-versus-younger patients receiving biological disease-modifying antirheumatic drugs, respectively. CONCLUSION: This systematic review provides the necessary evidence for developing CPG for the management of RA in older adults.

DOI： 10.1080/14397595.2021.1912922

Relationship between the physician-based clinical scale for foot and ankle surgery and patient-reported outcomes in patients with long-standing rheumatoid arthritis: Results from a multicenter prospective observational cohort study

Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M., Ishiguro, N.

Modern Rheumatology 31 ( 3 ) 607 - 613 2021年5月

運動器疼痛を対象とした医療体制腰痛に対するチームアプローチ

鉄永倫子, 鉄永智紀, 西田圭一郎

ペインクリニック 42 ( 別冊春 ) 247 - 254 2021年5月

記述言語：日本語出版者・発行元：真興交易(株)医書出版部

腰痛、特に3ヵ月以上症状が持続する慢性腰痛においては、器質的な要因のみならず、心理社会的な因子(psychological and social factors)が少なからず影響している。したがって、治療にあたり生物心理社会モデルに沿って病態を評価し、多職種が連携したチームでの集学的アプローチが有用である。われわれは、2012年より運動器慢性痛に対する集学的アプローチとして「痛みリエゾン外来」を開設し、多角的集学的な外来を多職種で行っている。慢性腰痛の患者さんの一例を提示しながら当センターでのチームアプローチを紹介する。(著者抄録)

Risk factors of postoperative delayed wound healing in patients with rheumatoid arthritis treated with a biological agent. 国際誌

Shunji Okita, Hajime Ishikawa, Asami Abe, Satoshi Ito, Kiyoshi Nakazono, Akira Murasawa, Keiichiro Nishida, Toshifumi Ozaki

Modern rheumatology 31 ( 3 ) 587 - 592 2021年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: This retrospective study aimed to investigate the risk factors associated with delayed wound healing (DWH) after orthopedic surgery in rheumatoid arthritis (RA) patients treated with biological disease-modifying antirheumatic drugs (bDMARDs). METHODS: We reviewed medical records of 276 orthopedic procedures for 187 RA patients treated with bDMARDs. As a preoperative nutritional status assessment, we evaluated body mass index, prognostic nutritional index (PNI), and controlling nutritional status (CONUT). We evaluated DAS28-CRP, DAS28-ESR, face scale, global health, and HAQ-DI to assess the disease activity. Univariate and multivariate logistic regression analyses were performed to evaluate the risk factors for DWH. RESULTS: In 276 procedures, DWH was identified in 24 patients (8.7%). Disease duration, foot and ankle surgery, and preoperative use of tocilizumab were significant in the univariate analyses. These variables were entered into a multivariate model, and it was revealed that preoperative use of tocilizumab and procedures in the foot and ankle were associated with an increased risk of DWH. CONCLUSION: The current retrospective study suggested that preoperative use of tocilizumab and procedures in the foot and ankle were risk factors for DWH.

DOI： 10.1080/14397595.2020.1790138

慢性疼痛患者に対するロコモティブシンドローム診断における診断時の特徴及び注意点

辻寛謙, 三澤治夫, 千田益生, 西田圭一郎, 濱田全紀, 堅山佳美, 鉄永智紀, 小田孔明, 伊勢真人, 梶木裕矢, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 6 2021年5月

65歳以下の慢性疼痛患者におけるロコモティブシンドロームと体組成及び運動機能評価

辻寛謙, 三澤治夫, 千田益生, 西田圭一郎, 濱田全紀, 堅山佳美, 鉄永智紀, 小田孔明, 伊勢真人, 梶木裕矢, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 7 2021年5月

慢性疼痛患者に対するロコモティブシンドローム診断における診断時の特徴及び注意点

辻寛謙, 三澤治夫, 千田益生, 西田圭一郎, 濱田全紀, 堅山佳美, 鉄永智紀, 小田孔明, 伊勢真人, 梶木裕矢, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 6 2021年5月

65歳以下の慢性疼痛患者におけるロコモティブシンドロームと体組成及び運動機能評価

辻寛謙, 三澤治夫, 千田益生, 西田圭一郎, 濱田全紀, 堅山佳美, 鉄永智紀, 小田孔明, 伊勢真人, 梶木裕矢, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 58 ( 特別号 ) 2 - 7 2021年5月

手根管症候群患者に対する神経伝導検査の術後成績予後予測能の検討

斎藤太一, 伊勢真人, 堀田佳史, 根津智史, 松橋美波, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 38 ( 1 ) O23 - 34 2021年4月

母指CM関節症に対する関節鏡下腱挿入形成術の手術成績

橋詰博行, 竹下歩, 小坂義樹, 齋藤太一, 西田圭一郎

日本手外科学会雑誌 38 ( 1 ) O31 - 41 2021年4月

母指CM関節症に対する関節鏡下腱挿入形成術の手術成績

橋詰博行, 竹下歩, 小坂義樹, 齋藤太一, 西田圭一郎

日本手外科学会雑誌 38 ( 1 ) O31 - 41 2021年4月

Modern rheumatology 32 ( 1 ) 1 - 6 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: This study aimed to evaluate satisfaction with total joint replacement (TJR) surgery among patients with rheumatoid arthritis (RA). METHODS: We mailed questionnaires to randomly selected members of the Japan Rheumatism Friendship Association, stratified by age and prefecture, throughout Japan. The questionnaire collected demographic and clinical characteristics as well as patients' satisfaction with TJR and their current therapy. RESULTS: Of the 1156 patients who returned the questionnaire, 339 (29.3%) responded that they had had TJR of any type. The mean age was 66.6 years, and 94.4% were women. The mean time period from the hip and knee TJR was 14-15 years. Over half of the patients who had had TJR were satisfied with the results, especially those who had had hip (89.6%) and knee TJR (87.3%), who reported a high level of satisfaction. Multivariable linear regression analysis revealed that, in patients with knee TJR, satisfaction with current therapy was significantly related to whether they were satisfied with the results of the surgery. CONCLUSION: Most patients with RA who had undergone TJR were satisfied with the results even after a long period of time, and their level of satisfaction was associated with their satisfaction with current therapy.

DOI： 10.1080/14397595.2021.1892258

慢性疼痛患者を対象とした痛みリエゾン外来における活動能力の帰結の類型化に関する検討

骨・関節・カルシウム代謝疾患変形性関節症

宮澤慎一, 西田圭一郎, 西原茂樹, 神崎浩孝, 千堂年昭

薬局 2021年増刊病気とくすり2021 72 ( 4 ) 870 - 887 2021年3月

太田晴之, 齋藤圭介, 原田和宏, 京極真, 鉄永倫子, 西田圭一郎, 千田益生

日本保健科学学会誌 23 ( 4 ) 176 - 186 2021年3月

記述言語：日本語出版者・発行元：日本保健科学学会

[目的]慢性疼痛患者を対象とする、痛みリエゾン外来における治療後の活動能力の帰結を類型化し、各集団の開始時の属性と活動能力の回復推移の特徴を後方視的に検討すること。[対象と方法]当院の痛みリエゾン外来受診患者のうち、6ヵ月間の治療継続が可能であった112例。活動能力の指標にはPDAS修正因子構造モデル13項目を用い、治療終了時点のデータを基に潜在ランク理論を用い類型化した。また各ランク間で開始時の属性、活動能力得点の継時的推移を比較検討した。[結果]潜在ランク数の推定では、ランク3が適合度の許容水準を満たした。また各ランク間で開始時の身体的パフォーマンスと心理的属性に統計的有意差を認め、活動能能力の得点推移は開始時より各時点で統計的有意差を示した。[結語]痛みリエゾン外来における活動能力の帰結は3つの集団に類型化できる事、各集団は開始時の属性、活動能力の推移とともに異なる特徴を示す事を明らかにした。(著者抄録)

慢性疼痛患者におけるロコモティブシンドローム有病率とその特徴

女性脊椎脊髄外科医の挑戦電気グループから岡山脊椎グループの異端児へ

鉄永倫子, 鉄永智紀, 西田圭一郎, 三澤治夫, 尾崎敏文

Journal of Spine Research 12 ( 3 ) 51 - 51 2021年3月

65歳以下の慢性腰痛患者におけるロコモティブシンドローム有病率とその特徴

辻寛謙, 鉄永倫子, 三澤治夫, 鉄永智紀, 山根健太郎, 小田孔明, 高尾真一郎, 梶木裕矢, 西田圭一郎, 尾崎敏文

Journal of Spine Research 12 ( 3 ) 333 - 333 2021年3月

神経障害性疼痛に対するアプローチミロガバリンへの期待

鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

Journal of Spine Research 12 ( 3 ) 238 - 238 2021年3月

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S934 - S934 2021年3月

慢性疼痛患者の自己効力感は介護者の介護負担度に影響を与える

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S919 - S919 2021年3月

関節リウマチ超音波検査におけるデジタルカメラ画像とAIを用いたボディーマーク付与

中原龍一, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 555 - 555 2021年3月

生物学的製剤と手術当科におけるリウマチ外科手術1569例の患者背景

那須義久, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 343 - 343 2021年3月

Differences between the root and horn cells of the human medial meniscus from the osteoarthritic knee in cellular characteristics and responses to mechanical stress.

Yuki Okazaki, Takayuki Furumatsu, Yusuke Kamatsuki, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Taichi Saito, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 2 ) 230 - 236 2021年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Many histological, mechanical, and clinical studies have been performed on the medial meniscus posterior root attachment, as it often tears in patients with osteoarthritic knee. Medial meniscal root repair is recommended in clinical situations; however, to date, no studies have examined the differences between meniscal root and horn cells. The aim of this study was, therefore, to investigate the morphology, reaction to cyclic tensile strain, and gene expression levels of medial meniscal root and horn cells. METHODS: Meniscal samples were obtained from the medial knee compartments of 10 patients with osteoarthritis who underwent total knee arthroplasty. Root and horn cells were cultured in Dulbecco's modified Eagle's medium without enzymes. The morphology, distribution, and proliferation of medial meniscal root and horn cells, as well as the gene and protein expression levels of Sry-type HMG box 9 and type II collagen, were determined after cyclic tensile strain treatment. RESULTS: Horn cells had a triangular morphology, whereas root cells were fibroblast-like. The number of horn cells positive for Sry-type HMG box 9 and type II collagen was considerably higher than that of root cells. Although root and horn cells showed similar levels of proliferation after 48, 72, or 96 h of culture, more horn cells than root cells were lost following a 2-h treatment with 5% and 10% cyclic tensile. Sry-type HMG box 9 and α1(II) collagen mRNA expression levels were significantly enhanced in both cells after 2- and 4-h cyclic tensile strain (5%) treatment. CONCLUSIONS: Medial meniscal root and horn cells have distinct morphologies, reactions to mechanical stress, and cellular phenotypes. Our results suggest that physiological tensile strain is important to activate extracellular matrix production in horn cells.

DOI： 10.1016/j.jos.2020.02.015

慢性疼痛患者の自己効力感は介護者の介護負担度に影響を与える

骨折を伴ったリウマチ肘に対するPROSNAPを用いた人工肘関節全置換術の治療成績

堀田佳史, 西田圭一郎, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 602 - 602 2021年3月

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S919 - S919 2021年3月

骨粗鬆症と骨代謝ロモソズマブ治療における関節リウマチの影響

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 高杉幸司, 江澤和彦, 井上貴絵, 藤田慎一朗, 與座未来, 金谷麻未, 新名早希子, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 365 - 365 2021年3月

慢性疼痛患者におけるロコモティブシンドローム有病率とその特徴

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 95 ( 3 ) S934 - S934 2021年3月

生物学的製剤と手術当科におけるリウマチ外科手術1569例の患者背景

那須義久, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 343 - 343 2021年3月

骨折を伴ったリウマチ肘に対するPROSNAPを用いた人工肘関節全置換術の治療成績

堀田佳史, 西田圭一郎, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 602 - 602 2021年3月

関節リウマチ超音波検査におけるデジタルカメラ画像とAIを用いたボディーマーク付与

中原龍一, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 555 - 555 2021年3月

ロモソズマブ治療において骨粗鬆症の前治療が与える影響、投与1年時の効果予測因子について

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 高杉幸司, 江澤和彦, 井上貴絵, 藤田慎一朗, 與座未来, 金谷麻未, 新名早希子, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 65回 610 - 610 2021年3月

Modern rheumatology 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system. METHODS: We searched PubMed, Japana Centra Revuo Medicina Web, and the Cochrane Library (from 2009 to 2018) to identify articles that evaluated PROs of exercise therapy and RA disease activity. RESULTS: A total of 662 articles were identified, including nine RCTs, and meta-analyses were performed on six RCTs on systemic exercise therapy and three RCTs on upper extremity exercise therapy. Analyzed exercise therapies were diverse, differing in target population, intervention method, and duration. Significant improvements were observed in the Health Assessment Questionnaire Disability Index (mean difference -0.35, 95% confidence interval (CI): -0.60 to -0.10), pain (standardized mean difference -2.04, 95% CI: -3.77 to -0.32), and SF-36. For upper extremity exercise therapy, significant improvements in PROs (Disabilities of the Arm, Shoulder, and Hand Questionnaire, Michigan Hand Outcome Questionnaire) were observed. CONCLUSION: Exercise therapy in RA treatment improves patient subjective assessment of pain, physical function, and quality of life.

DOI： 10.1080/14397595.2021.1886653

Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis

整形外科からみた treat to target - 何を重視するか -

西田圭一郎

整形・災害外科 64 ( 2 ) 131 - 140 2021年2月

Yuko Kaneko, Yutaka Kawahito, Masayo Kojima, Takeo Nakayama, Shintaro Hirata, Mitsumasa Kishimoto, Hirahito Endo, Yohei Seto, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern Rheumatology 31 ( 1 ) 61 - 69 2021年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Oxford University Press (OUP)

Objectives: To evaluate the efficacy and safety of tacrolimus in adult patients with rheumatoid arthritis (RA) by using the GRADE approach. Methods: We searched PubMed, Japana Centra Revuo Medicina Web (Ichu-shi web), and the Cochrane Database of Systematic Reviews. Articles fulfilling the predefined inclusion criteria were appraised and used for meta-analysis. The primary outcomes were American College of Rheumatology 20 (ACR20) and serum creatinine elevation. Other outcomes included ACR50, ACR70, changes in C-reactive protein, modified Health Assessment Questionnaire Disability Index, gastrointestinal disorders, metabolic and nutritional disorders, and infections and infestations. Results: We identified five randomized controlled studies, four of which compared tacrolimus to placebo and were included in the meta-analysis. The risk ratio of ACR20 achievement was 1.71 (95% confidence interval [CI] 1.20-2.42) for 1-2 mg/day and 2.30 (95% CI 1.79-2.96) for 3 mg/day. The risk ratio of creatinine elevation was 1.95 (95% CI 1.18-3.23) for 1-2 mg/day and 3.81 (95% CI 2.43-5.99) for 3 mg/day. Conclusion: Tacrolimus is effective with acceptable safety in the management of RA.

DOI： 10.1080/14397595.2020.1719607

RANKL expression in chondrocytes and its promotion by lymphotoxin-α in the course of cartilage destruction during rheumatoid arthritis. 国際誌

Ayumu Takeshita, Keiichiro Nishida, Aki Yoshida, Yoshihisa Nasu, Ryuichi Nakahara, Daisuke Kaneda, Hideki Ohashi, Toshifumi Ozaki

PloS one 16 ( 7 ) e0254268 2021年

記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the expression and localization of the receptor activator nuclear factor κB ligand (RANKL) in cartilage from patients with rheumatoid arthritis (RA) of relevance to cartilage degeneration. We also examined the role of exogenous lymphotoxin (LT)-α on RANKL expression in human chondrocytes and its effect on in vitro osteoclast differentiation. Cartilage and synovial fluid samples were obtained from 45 patients undergoing total joint replacement surgery or joint puncture, including 24 patients with osteoarthritis (OA) and 21 patients with RA. RANKL expression in articular cartilage was examined by immunohistochemistry. LT-α concentrations in synovial fluid were measured using an enzyme-linked immunosorbent assay (ELISA). Normal human chondrocytes were stimulated with LT-α, and the relative mRNA levels of RANKL, osteoprotegerin (OPG), matrix metalloproteinase-9, and vascular endothelial growth factor were examined by real-time polymerase chain reaction. Soluble RANKL protein in culture media was measured using ELISA, and membrane-bound RANKL protein in cells was examined by western blotting. Co-cultures of human chondrocytes with peripheral blood mononuclear cells (PBMCs) were stimulated with macrophage-colony stimulating factor and LT-α, and osteoclast differentiation was evaluated by staining for tartrate-resistant acid phosphatase. LT-α concentrations were higher in RA synovial fluid than in OA samples. The population of RANKL-positive chondrocytes of RA cartilage was higher than that of OA cartilage, and correlated with cartilage degeneration. Stimulation of cultured human chondrocytes by LT-α increased RANKL expression, the RANKL/OPG ratio, and angiogenic factors. Membrane-bound RANKL in chondrocytes was up-regulated after stimulation of LT-α, whereas soluble RANKL in culture medium did not increase. Co-cultures of human chondrocytes and PBMCs demonstrated that LT-α stimulated human chondrocytes to produce RANKL and induced osteoclastic differentiation of PBMCs. RANKL produced by chondrocytes may contribute to cartilage destruction during RA and LT-α could promote the expression of RANKL in human chondrocytes.

DOI： 10.1371/journal.pone.0254268

慢性疼痛患者におけるロコモティブシンドロームと身体機能及び体組成評価

Swanson型シリコンインプラントを用いた母指MP関節形成術後30年経過した1例

沖田駿治, 石川肇, 阿部麻美, 中園清, 村澤章, 西田圭一郎

関節の外科 48 ( 2 ) 72 - 72 2021年

人工肘関節置換術〜unlinkedとlinkedの適応と課題〜岡山大式人工肘関節の開発の経緯と今後の課題

西田圭一郎, 那須義久, 橋詰謙三, 原田遼三, 中原龍一

関節の外科 48 ( 2 ) 47 - 47 2021年

65歳以下の慢性疼痛患者におけるロコモティブシンドローム体組成及び身体機能評価

辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本サルコペニア・フレイル学会雑誌 4 ( Suppl. ) 150 - 150 2020年11月

65歳以下の慢性疼痛患者におけるロコモティブシンドローム有病率及び特徴について

辻寛謙, 鉄永倫子, 鉄永智紀, 福岡史郎, 西田圭一郎, 尾崎敏文

日本サルコペニア・フレイル学会雑誌 4 ( Suppl. ) 149 - 149 2020年11月

処方エキスパートへの道高齢者における抗不安薬の使い方

植田真司, 井上真一郎, 西田圭一郎

Loco Cure 6 ( 4 ) 357 - 360 2020年11月

炎症と運動器疼痛特集運動器の痛み：どこから来るのか？どこへ行くのか？

西田圭一郎, 宮澤慎一

Bone Joint Nerve 10 ( 4 ) 529 - 534 2020年10月

疼痛の集学的治療特集運動器の痛み：どこから来るのか？どこへ行くのか？

鉄永倫子, 鉄永智紀, 西田圭一郎

Bone Joint Nerve 10 ( 4 ) 643 - 650 2020年10月

辻寛謙, 鉄永倫子, 鉄永智紀, 福岡史朗, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 12 ( 4 ) S70 - S70 2020年10月

慢性疼痛患者における同居者の介護負担度に与える因子の検討

辻寛謙, 鉄永倫子, 鉄永智紀, 福岡史朗, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 12 ( 4 ) S69 - S69 2020年10月

65歳以下の慢性疼痛患者におけるロコモティブシンドローム有病率とその特徴

辻寛謙, 鉄永倫子, 鉄永智紀, 福岡史朗, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 12 ( 4 ) S71 - S71 2020年10月

慢性疼痛患者における排便と疼痛関連因子との関連

福岡史朗, 梶木裕矢, 高尾真一郎, 小田孔明, 山根健太郎, 三澤治夫, 尾崎敏文, 辻寛謙, 鉄永倫子, 鉄永智紀, 西田圭一郎

Journal of Musculoskeletal Pain Research 12 ( 4 ) S82 - S82 2020年10月

関節リウマチ診療における見逃し・誤診

西田圭一郎

39 ( 10月増刊 ) 132 - 140 2020年10月

Cognitive factors associated with locomotive syndrome in chronic pain patients: A retrospective study.

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Haruo Misawa, Keiichiro Nishida, Toshifumi Ozaki

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 26 ( 5 ) 896 - 901 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Elsevier BV

BACKGROUND: Prevention and treatment for locomotive syndrome (LS) are important for extending healthy life expectancy. The 25-question geriatric locomotive function scale (GLFS-25) was developed to diagnose LS. The Fear-Avoidance model was proposed to explain pain chronicity. LS and chronic pain decrease activities of daily living; however, the relationships between LS and factors related to chronic pain in the Fear-Avoidance model are unknown. Objective of the current study was to assess the prevalence of LS and examine the factors of the Fear-Avoidance model and the GLFS-25 that affect the prevalence of LS in patients with chronic pain. METHODS: Participants included 281 patients (99 men, 182 women) aged over 40 years with chronic pain who visited our outpatient clinic for chronic pain. All participants completed the GLFS-25, numeric rating scale (NRS), pain catastrophizing scale (PCS), hospital anxiety and depression scale (HADS), and Athene insomnia scale (AIS). According to a GLFS-25 cutoff point, participants were divided into three groups (LS-2; GLFS-25 ≥ 16, LS-1; 7 ≤ GLFS-25 < 16, and non-LS; GLFS-25 < 7 points) and each parameter was compared among the groups, followed by multiple logistic regression analysis. Next, multiple linear regression analysis was performed to determine the factors associated with the GLFS-25. RESULTS: Of all 281 patients, 241 (85.8%) patients were diagnosed with LS-2. Univariate analysis revealed there were significant differences in NRS, PCS, HADS anxiety, HADS depression, and AIS among groups. Multiple logistic regression analyses showed PCS was significantly associated with LS-2 prevalence. The GLFS-25 was positively correlated with NRS, HADS depression, AIS in multiple linear regression analysis. CONCLUSIONS: We found that patients with chronic pain in our outpatient clinic had a significant rate of LS-2. The prevalence of LS-2 was significantly correlate with pain catastrophizing, and the GLFS-25 was significantly correlated with higher pain intensity, depression, and insomnia.

DOI： 10.1016/j.jos.2020.08.007

AIを用いた関節リウマチの超音波動画評価

中原龍一, 西田圭一郎, 那須義久, 渡辺雅仁, 松橋美波, 堀田佳史, 品岡玲, 尾崎敏文

日本関節病学会誌 39 ( 3 ) 192 - 192 2020年9月

舟状骨偽関節に対する手術方法別の治療成績

堀田佳史, 齋藤太一, 近藤宏也, 根津智史, 松橋美波, 上原健敬, 島村安則, 野田知之, 西田圭一郎, 尾崎敏文

骨折 42 ( Suppl. ) S245 - S245 2020年9月

関節リウマチ患者滑膜におけるCD30の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 94 ( 8 ) S1655 - S1655 2020年9月

生物学的製剤とJAK阻害剤使用例の手術部位感染/創治癒遅延発生率の検討

那須義久, 木曽洋平, 堀田佳史, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 39 ( 3 ) 229 - 229 2020年9月

関節リウマチにおけるADAM12の役割

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 松橋美波, 堀田佳久, 尾崎敏文

日本関節病学会誌 39 ( 3 ) 191 - 191 2020年9月

運動器慢性痛に対する多面的アプローチ

鉄永倫子, 鉄永智紀, 西田圭一郎

日本運動器疼痛学会誌 12 ( 3 ) 248 - 250 2020年9月

記述言語：日本語出版者・発行元：(一社)日本運動器疼痛学会

運動器慢性痛に対しては,多職種連携のチームアプローチ,多面的なアプローチが有用であることが認識されつつある。運動器慢性痛の患者さんのゴールは生活であること,その目的を共有し実践するためには,いろいろな因子を多面的に評価し,食事,睡眠,運動,生活リズム,生活習慣に目を向けた多職種によるトータルマネージメントが重要である。そして,暗くなりがちな痛み診療を明るい医療を目指し,臨んでいきたいと考えている。(著者抄録)

SBi silicone人工指関節(旧AVANTA)を用いたMCP人工関節置換術の治療成績

松橋美波, 西田圭一郎, 中原龍一, 那須義久, 尾崎敏文

関節の外科 47 ( 2 ) 93 - 93 2020年8月

リウマチ外科のアイデンティティーリウマチ肘・手関節手術の変化

那須義久, 西田圭一郎, 中原龍一, 堀田佳史, 渡辺雅仁, 松橋美波, 尾崎敏文

関節の外科 47 ( 2 ) 76 - 76 2020年8月

似て非なるリウマチ手と足の手術関節リウマチに対する手指関節手術の現状

那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 239 - 239 2020年8月

リウマチ性疾患の基礎研究 CD30をターゲットとした関節リウマチ新規治療の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 521 - 521 2020年8月

リウマチ性疾患の画像 AIを用いた関節リウマチ超音波検査における同一画像自動検出

中原龍一, 西田圭一郎, 松橋美波, 渡辺雅仁, 木曽洋平, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 421 - 421 2020年8月

関節リウマチの滑膜細胞増殖におけるADAM12の役割

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 木曽洋平, 松橋美波, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 630 - 630 2020年8月

処方エキスパートへの道高齢者の睡眠薬の使い方

植田真司, 井上真一郎, 西田圭一郎

Loco Cure 6 ( 3 ) 258 - 261 2020年8月

生物学的製剤治療を行った関節リウマチ患者における関節破壊の解析

浅野澄恵, 高杉幸司, 江澤和彦, 原田遼三, 藤田慎一朗, 山本渉, 中原龍一, 那須義久, 西田圭一郎

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 561 - 561 2020年8月

バリシチニブを休薬せず行った整形外科手術の小経験

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 高杉幸司, 浅野澄恵, 藤田慎一朗, 井上貴絵, 山本渉, 與座未来, 金谷麻未, 新名早希子, 江澤和彦

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 574 - 574 2020年8月

実臨床における早期関節リウマチに対する治療選択と短期成績多施設前向きコホート研究NICER-Jより

鈴木望人, 平野裕司, 祖父江康司, 原良太, 金子哲也, 辻成佳, 長嶺里美, 西梅剛, 吉岡裕, 乾健太郎, 岡邨興一, 藤林孝義, 渡部達生, 石川肇, 高窪祐弥, 西田圭一郎, 鳥養栄治, 高木英希, 金子敦史, 小口武, 寺部健哉, 浅井秀司, 石黒直樹, 小嶋俊久

日本リウマチ学会総会・学術集会プログラム・抄録集 64回 719 - 719 2020年8月

地域包括ケア病棟における期限内退院可能な患者の特徴、予測モデルについて

原田遼三, 中原龍一, 那須義久, 西田圭一郎

The Japanese Journal of Rehabilitation Medicine 57 ( 特別号 ) 3 - 4 2020年7月

Short-term outcomes of mirogabalin in patients with peripheral neuropathic pain: a retrospective study. 国際誌

Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Haruo Misawa, Tomoyuki Takigawa, Kentaro Yamane, Hironori Tsuji, Yoshitaka Takei, Toshifumi Ozaki

Journal of orthopaedic surgery and research 15 ( 1 ) 191 - 191 2020年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Mirogabalin, which is approved for the treatment of peripheral neuropathic pain in Japan, is a ligand for the α2δ subunit of voltage-gated calcium channels. Both pregabalin and mirogabalin act as nonselective ligands at the α2δ-1 and α2δ-2 subunits. Mirogabalin has a unique binding profile and long duration of action. Pregabalin has been reported to produce intolerable adverse effects in some patients. This study investigated outcomes associated with mirogabalin administration in patients with peripheral neuropathic pain who ceased treatment with pregabalin. METHODS: We retrospectively assessed peripheral neuropathic pain using the neuropathic pain screening questionnaire (NeP score) in 187 patients (58 men, 129 women) who were treated with mirogabalin. All patients had switched from pregabalin to mirogabalin due to lack of efficacy or adverse events. Differences in the treatment course (i.e., numeric rating scale (NRS) scores) were compared using one-way analysis of variance with Bonferroni post hoc tests. RESULTS: The mean age of the patients was 72.3 years (range, 30-94 years), and the mean duration of disease was 37 months (range, 3-252 months). After treatment with mirogabalin for 1 week, NRS scores significantly decreased compared with baseline and continued to decrease over time. After 8 weeks, NRS scores improved by ≥ 30% from baseline in 113 patients (69.3%). Twenty-four patients (12.8%) stopped mirogabalin treatment due to adverse events. Somnolence (26.7%), dizziness (12.3%), edema (5.9%), and weight gain (0.5%) were noted as adverse events of mirogabalin. CONCLUSIONS: The results of this investigation indicate that mirogabalin is safe and effective for reducing peripheral neuropathic pain.

DOI： 10.1186/s13018-020-01709-3

TEA後に許容される運動と実態調査

橋詰謙三, 西田圭一郎

整形・災害外科 63 ( 6 ) 817 - 824 2020年5月

Induction of CEMIP in Chondrocytes by Inflammatory Cytokines: Underlying Mechanisms and Potential Involvement in Osteoarthritis. 査読国際誌

Takashi Ohtsuki, Omer F Hatipoglu, Keiichi Asano, Junko Inagaki, Keiichiro Nishida, Satoshi Hirohata

International journal of molecular sciences 21 ( 9 ) 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

In patients with osteoarthritis (OA), there is a decrease in both the concentration and molecular size of hyaluronan (HA) in the synovial fluid and cartilage. Cell migration-inducing hyaluronidase 1 (CEMIP), also known as hyaluronan (HA)-binding protein involved in HA depolymerization (HYBID), was recently reported as an HA depolymerization-related molecule expressed in the cartilage of patients with OA. However, the underlying mechanism of CEMIP regulation is not well understood. We found that CEMIP expression was transiently increased by interleukine-1β (IL-1β) stimulation in chondrocytic cells. We also observed that ERK activation and NF-κB nuclear translocation were involved in the induction of CEMIP by IL-1β. In addition, both administration of HA and mechanical strain attenuated the CEMIP induction in IL-1β-stimulated chondrocytes. In conclusion, we clarified the regulatory mechanism of CEMIP in chondrocytes by inflammatory cytokines and suggested the potential involvement in osteoarthritis development.

DOI： 10.3390/ijms21093140

関節リウマチによる高度拘縮肘に対するPROSNAP人工肘の使用経験

那須義久, 中原龍一, 松橋美波, 渡辺雅仁, 木曽洋平, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 32 ( 1 ) 184 - 184 2020年4月

超音波ガイド下関節穿刺が診断治療に有用であった股関節偽痛風の2例

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 尾崎敏文, 原田遼三

中国・四国整形外科学会雑誌 32 ( 1 ) 1 - 7 2020年4月

記述言語：日本語出版者・発行元：中国・四国整形外科学会

症例1は93歳女性で、右膝痛による体動困難を主訴とした。CT、超音波で右股関節包内前方に水腫と石灰化像を認め、超音波ガイド下に股関節穿刺吸引を施行した。関節液の検査結果は比重1.015、尿酸結晶(-)、CPPD結晶(+)、細胞数46325/μL(分画:Stab1%、Seg85%、Mono13%、Lymph1%)、糖77mg/dL、塗抹菌体(-)であり、股関節偽痛風と診断した。穿刺の際にキシロカインを投与し、症状が速やかに改善した。症例2は81歳女性で、誘因のない右股関節痛を主訴とした。CT、超音波で右股関節包内前方に水腫と石灰化像を認め、超音波ガイド下に股関節穿刺吸引を施行した。関節液の検査結果は比重1.020、尿酸結晶(-)、CPPD結晶(+)、細胞数20800/μL(分画:Stab0%、Seg82%、Mono13%、Lymph8%)、糖155mg/dL、塗抹菌体(-)であり、股関節偽痛風と診断した。穿刺の際にキシロカインを投与し、症状が速やかに改善した。以後、2例とも疼痛の再燃を認めなかった。

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J02438&link_issn=&doc_id=20200602230001&doc_link_id=%2Fcm4ortho%2F2020%2F003201%2F001%2F0001-0007%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcm4ortho%2F2020%2F003201%2F001%2F0001-0007%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

橈骨遠位端骨折プレート橈骨遠位端骨折に対するDVRを使用した手術治療

島村安則, 斎藤太一, 西田圭一郎, 尾崎敏文, 近藤秀則, 森谷史郎, 今谷潤也

日本手外科学会雑誌 36 ( 6 ) 1068 - 1068 2020年4月

舟状骨偽関節に対する低侵襲治療の術後成績

堀田佳史, 斎藤太一, 根津智史, 松橋美波, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 37 ( 1 ) O18 - 1 2020年4月

外傷性母指ボタン穴変形に対し手術加療を行った2例

沖田駿治, 福田祥二, 門田康孝, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 37 ( 1 ) P48 - 2 2020年4月

尺骨末端切除術(Darrach法)後に手指伸筋腱再断裂を生じた1例

那須義久, 大橋基秀, 木曽洋平, 沖田駿治, 渡辺雅仁, 松橋美波, 中原龍一, 西田圭一郎, 尾崎敏文

岡山医学会雑誌 132 ( 1 ) 48 - 48 2020年4月

Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs? 国際誌

Hiromu Ito, Shigeyoshi Tsuji, Masanori Nakayama, Yuichi Mochida, Keiichiro Nishida, Hajime Ishikawa, Toshihisa Kojima, Takumi Matsumoto, Ayako Kubota, Takeshi Mochizuki, Koji Sakuraba, Isao Matsushita, Arata Nakajima, Ryota Hara, Akihisa Haraguchi, Tsukasa Matsubara, Katsuaki Kanbe, Natsuko Nakagawa, Masahide Hamaguchi, Shigeki Momohara

The Journal of Rheumatology 47 ( 4 ) 502 - 509 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：The Journal of Rheumatology

<sec><title>Objective.</title>To investigate whether abatacept (ABA) causes more adverse events (AE) than conventional synthetic disease-modifying antirheumatic drugs (csDMARD) after orthopedic surgery in patients with rheumatoid arthritis (RA).

</sec><sec><title>Methods.</title>A retrospective multicenter nested case–control study was performed in 18 institutions. Patients receiving ABA (ABA group) were matched individually with patients receiving csDMARD and/or steroids (control group). Postoperative AE included surgical site infection, delayed wound healing, deep vein thrombosis or pulmonary embolism, flare, and death. The incidence rates of the AE in both groups were compared with the Mantel-Haenszel test. Risk factors for AE were analyzed by logistic regression model.

</sec><sec><title>Results.</title>A total of 3358 cases were collected. After inclusion and exclusion, 2651 patients were selected for matching, and 194 patients in 97 pairs were chosen for subsequent comparative analyses between the ABA and control groups. No between-group differences were detected in the incidence rates of each AE or in the incidence rates of total AE (control vs ABA: 15.5% vs 20.7% in total, 5.2% vs 3.1% in death).

</sec><sec><title>Conclusion.</title>Compared with csDMARD and/or steroids without ABA, adding ABA to the treatment does not appear to increase the incidence rates of postoperative AE in patients with RA undergoing orthopedic surgery. Large cohort studies should be performed to add evidence for the perioperative safety profile of ABA.

</sec>

DOI： 10.3899/jrheum.181100

運動器慢性痛患者に対する就労支援のシステム構築を目指して

上肢の人工関節人工肘関節置換術の臨床成績

西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 94 ( 3 ) S528 - S528 2020年3月

鉄永倫子, 鉄永智紀, 西田圭一郎, 松崎孝, 井上真一郎, 太田晴之, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S95 - S95 2020年3月

慢性腰痛患者におけるデュロキセチン塩酸塩の効果は抑うつの有無により影響するか

鉄永倫子, 鉄永智紀, 三澤治夫, 瀧川朋亨, 山根健太郎, 西田圭一郎, 竹井義隆, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S297 - S297 2020年3月

CD30をターゲットとした新規リウマチ治療の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 94 ( 2 ) S152 - S152 2020年3月

人工知能を用いた超音波画像の同一画像自動検出

中原龍一, 西田圭一郎, 渡辺雅仁, 松橋美波, 木曽洋平, 那須義久, 尾崎敏文

日本整形外科学会雑誌 94 ( 3 ) S701 - S701 2020年3月

骨・関節・カルシウム代謝疾患変形性関節症

宮澤慎一, 西田圭一郎, 西原茂樹, 神崎浩孝, 千堂年昭

薬局 2020年増刊病気とくすり2020 71 ( 4 ) 888 - 905 2020年3月

Idiopathic Chondrolysis of the Hip Treated by Immunosuppressive Therapy and Arthroscopic Intervention.

Hirosuke Endo, Hirofumi Akazawa, Masato Yashiro, Kazuki Yamada, Tomoaki Sanki, Tomonori Tetsunaga, Keiichiro Nishida, Takayuki Furumatsu, Toshifumi Ozaki

Acta medica Okayama 74 ( 1 ) 77 - 81 2020年2月

記述言語：英語

Idiopathic chondrolysis of the hip (ICH), a very rare disorder of unknown etiology, occurs mainly in female adolescents. Characterized by pain, limp, stiffness and radiological narrowing joint space from the rapid destruction of the articular cartilage, ICH sometimes results in ankyloses. We present the case of a 10-year-old girl diagnosed with ICH based on arthroscopic inspection and synovium biopsy. The femoral deformity appeared gradually, like a cam-type femoroacetabular impingement. She was treated with intensive rehabilitation and immunosuppressive drug. We later performed an arthroscopic bumpectomy for residual symptoms. She achieved a favorable outcome as a 15-year-old at the latest follow-up.

DOI： 10.18926/AMO/57957

関節リウマチに対する小指MP人工指関節置換術の治療成績

松橋美波, 西田圭一郎, 那須義久, 齋藤太一, 木曽洋平, 尾崎敏文

日本手外科学会雑誌 36 ( 5 ) 784 - 787 2020年2月

記述言語：日本語出版者・発行元：(一社)日本手外科学会

関節リウマチの人工指関節置換術において小指は十分な可動域が得られにくいという問題点がある.著者らは,シリコンインプラント(SBi Silicone人工指関節:旧AVANTA人工指関節)による人工指関節置換術を行っており,2014年以降小指に対してはプレフレックスタイプを使用している.ストレートタイプ(S群)27例とプレフレックスタイプ(P群)21例に対し,術後1年時の握力,可動域,HAND20,DASHを調査し,比較検討した.術後1年時のMP関節の屈曲角度はS群50.1度,及びP群67.4度であり,可動域もS群33.5度,及びP群60.7度(P<0.01)であり有意に大きかった.他の検討項目では有意差を認めなかった.屈曲角度に影響する因子は様々であるが,プレフレックスタイプの選択により小指の屈曲は有意に増加し,可動域が増加した.(著者抄録)

術前・術後ケアのための「既往症の知識」まとめシート関節リウマチ

西田圭一郎

月刊ナーシング 40 ( 3 ) 40 - 43 2020年2月

Bone microarchitectural analysis using ultra-high-resolution CT in tiger vertebra and human tibia. 国際誌

Ryota Inai, Ryuichi Nakahara, Yusuke Morimitsu, Noriaki Akagi, Youhei Marukawa, Toshi Matsushita, Takashi Tanaka, Akihiro Tada, Takao Hiraki, Yoshihisa Nasu, Keiichiro Nishida, Toshifumi Ozaki, Susumu Kanazawa

European radiology experimental 4 ( 1 ) 4 - 4 2020年1月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: To reveal trends in bone microarchitectural parameters with increasing spatial resolution on ultra-high-resolution computed tomography (UHRCT) in vivo and to compare its performance with that of conventional-resolution CT (CRCT) and micro-CT ex vivo. METHODS: We retrospectively assessed 5 tiger vertebrae ex vivo and 16 human tibiae in vivo. Seven-pattern and four-pattern resolution imaging were performed on tiger vertebra using CRCT, UHRCT, and micro-CT, and on human tibiae using UHRCT. We measured six microarchitectural parameters: volumetric bone mineral density (vBMD), trabecular bone volume fraction (bone volume/total volume, BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), and connectivity density (ConnD). Comparisons between different imaging resolutions were performed using Tukey or Dunnett T3 test. RESULTS: The vBMD, BV/TV, Tb.N, and ConnD parameters showed an increasing trend, while Tb.Sp showed a decreasing trend both ex vivo and in vivo. Ex vivo, UHRCT at the two highest resolutions (1024- and 2048-matrix imaging with 0.25-mm slice thickness) and CRCT showed significant differences (p ≤ 0.047) in vBMD (51.4 mg/cm3 and 63.5 mg/cm3 versus 20.8 mg/cm3), BV/TV (26.5% and 29.5% versus 13.8 %), Tb.N (1.3 l/mm and 1.48 l/mm versus 0.47 l/mm), and ConnD (0.52 l/mm3 and 0.74 l/mm3 versus 0.02 l/mm3, respectively). In vivo, the 512- and 1024-matrix imaging with 0.25-mm slice thickness showed significant differences in Tb.N (0.38 l/mm versus 0.67 l/mm, respectively) and ConnD (0.06 l/mm3 versus 0.22 l/mm3, respectively). CONCLUSIONS: We observed characteristic trends in microarchitectural parameters and demonstrated the potential utility of applying UHRCT for microarchitectural analysis.

DOI： 10.1186/s41747-019-0135-0

RA手指変形 MCP人工関節置換術後のリハビリテーションについて

松山宜之, 中原龍一, 那須義久, 岡佳純, 千田益生, 西田圭一郎

MEDICAL REHABILITATION ( 244 ) 1 - 7 2020年1月

記述言語：日本語出版者・発行元：(株)全日本病院出版会

関節リウマチ(RA)手の障害は、スワンネック変形・ボタン穴変形・尺側偏位など多彩であり、一つの手に複数の変形が混在している。その中でも、中手指節(MCP)関節は早期から罹患率が高く関節変形が生じやすく、進行例ではシリコン製インプラントによるMCP人工関節置換術での良好な成績が報告されている。当院では、MCP人工関節置換術に対しては、スタンダードパスを用いて術後療法を行っている。しかし、RA手指においては隣接関節の障害や伸筋腱皮下断裂を伴っていることも多く、進行例の変形では必要に応じて追加手術が同時に実施される。本稿では、通常のMCP人工関節置換術からスワンネック変形・ボタン穴変形・若年者の関節変形の術後リハビリテーションについて概説する。(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J03505&link_issn=&doc_id=20200124130001&doc_link_id=%2Fap5meree%2F2020%2F000244%2F002%2F0001-0007%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fap5meree%2F2020%2F000244%2F002%2F0001-0007%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

The factors driving self-efficacy in intractable chronic pain patients: a retrospective study. 国際誌

Hironori Tsuji, Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Haruo Misawa, Toshifumi Ozaki

Journal of orthopaedic surgery and research 14 ( 1 ) 473 - 473 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The fear-avoidance model is a theoretical paradigm for explaining acute and chronic pain. In this model, pain catastrophizing plays an important role. On the other hand, self-efficacy influences whether patients view their pain optimistically, ultimately preventing the conversion of pain into intractable pain. The aim of the present study was to evaluate the factors that influence self-efficacy in patients with chronic pain. METHODS: Study participants included 147 outpatients (35 men, 112 women) with intractable chronic pain who visited our hospital between September 2014 and July 2015. Their mean age was 71.0 (range 32-92) years. Pain sites were as follows: low back, 97 patients; knee, 71 patients; shoulder, 34 patients; and hip, 15 patients. All patients were assessed using the following measures: Numeric Rating Scale (NRS), Pain Catastrophizing Scale (PCS), Hospital Anxiety and Depression Scale (HADS), Pain Disability Assessment Scale (PDAS), and Pain Self-Efficacy Questionnaire (PSEQ). All participants were further divided into two groups based on median PSEQ scores (group L: PSEQ of 35 points or less, n = 74; group H: PSEQ greater than 35 points, n = 73). The factors that influenced self-efficacy in these patients were analyzed using univariate and multiple linear regression analyses. RESULTS: Significant differences were observed in gender; pain duration; and NRS, PDAS, HADS, and PCS scores between group L and group H. Multiple linear regression analysis revealed that self-efficacy was correlated with PDAS score, HADS depression score, and pain duration. CONCLUSIONS: Patients with longer pain duration indicated greater self-efficacy and patients with higher pain disability and depression exhibited lower self-efficacy.

DOI： 10.1186/s13018-019-1535-9

関節リウマチに対するMCP関節人工関節置換術中に手関節部での腱剥離術を要した症例の検討

木曽洋平, 西田圭一郎, 松橋美波, 渡辺雅仁, 沖田駿治, 大橋秀基, 尾崎敏文, 那須義久, 中原龍一

日本関節病学会誌 38 ( 4 ) 471 - 477 2019年12月

記述言語：日本語出版者・発行元：(一社)日本関節病学会

当院でRA(関節リウマチ)に対しMCP関節人工関節置換術を施行した72例(手術時平均年齢61.8歳±11.9歳)を対象に、術中に手関節背側部の腱剥離術を要した症例について検討した。その結果、術中に手関節背側部の腱剥離術を要した症例は12例(16.7%)であった。更に手関節部での手術歴を有している症例では、15例中6例(40.0%)で術中に腱剥離術の追加が必要であった。手関節手術歴のある例ではEDCの癒着が多い傾向にあり、手術歴のない例では全例でEDMの癒着がみられた。腱剥離(+)群、腱剥離(-)群ともにHAND20、DASHは術後改善傾向を示し、改善量は両群間で有意差は認められなかった。

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J05177&link_issn=&doc_id=20191220140007&doc_link_id=%2Ffd8kanse%2F2019%2F003804%2F007%2F0471-0477%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffd8kanse%2F2019%2F003804%2F007%2F0471-0477%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

患者の満足度を高める関節リウマチ手術関節リウマチの肘関節手術の現状と展望

那須義久, 西田圭一郎

臨床整形外科 54 ( 12 ) 1213 - 1219 2019年12月

記述言語：日本語出版者・発行元：(株)医学書院

＜文献概要＞人工肘関節置換術(TEA)をはじめ,関節リウマチ(RA)では肘関節の障害に対して手術が必要となる例が以前は多くみられていた.薬物療法の進歩により減少はしているものの,手術適応症例がなくなることはない.本邦では優れた非連結型人工関節が開発され,特に最近いくつかの機種において10年以上にわたって90%を大きく上回るインプラント生存率など,優れた臨床成績が相次いで報告されている.今後は多関節罹患例や高度関節破壊例の減少と,インプラント性能・術式が改善されることでRA肘の手術成績はさらに向上するものと期待される.

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2019&ichushi_jid=J01554&link_issn=&doc_id=20191202070007&doc_link_id=10.11477%2Fmf.1408201534&url=https%3A%2F%2Fdoi.org%2F10.11477%2Fmf.1408201534&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Two cases of high tibial osteotomy in patients with rheumatoid arthritis treated with biologic disease-modifying anti-rheumatic drugs

Takahara, Y., Nishida, K., Nakashima, H., Ochi, N., Uchida, Y., Kato, H., Itani, S., Nakamura, M., Iwasaki, Y., Tsujimura, Y.

Acta Medica Okayama 73 ( 6 ) 537 - 542 2019年12月

A high incidence of extensor pollicis brevis insertion into the distal phalanx in rheumatoid arthritis patients who required the surgical reconstruction for thumb boutonnière deformity. 査読国際誌

Okita S, Nishida K, Ohtsuka A, Ozaki T

Modern rheumatology 29 ( 6 ) 954 - 958 2019年11月

慢性疼痛のFear-Avoidanceモデルにおける各因子とロコモ25との関連についての検討

辻寛謙, 鉄永倫子, 鉄永智紀, 辻暁里, 折田沙穂, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 11 ( 4 ) S61 - S61 2019年11月

慢性疼痛患者における活動性及びQOLはロコモ25と相関するか

辻暁里, 鉄永倫子, 鉄永智紀, 辻寛謙, 折田沙穂, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 11 ( 4 ) S60 - S60 2019年11月

再移植の実施と非実施による感染症の危険因子と感染率の比較(Risk Factors for Infection and Comparison of Infection Rate with and without Replantation)

斎藤太一, 根津智史, 松橋美波, 島村安則, 西田圭一郎, 湯本哲也, 中尾篤典, 尾崎敏文

日本マイクロサージャリー学会学術集会プログラム・抄録集 46回 127 - 127 2019年11月

慢性疼痛外来において初診時付き添いの有無と各種疼痛スコアとの関連性

折田沙穂, 鉄永倫子, 鉄永智紀, 辻寛謙, 辻暁里, 西田圭一郎, 尾崎敏文

Journal of Musculoskeletal Pain Research 11 ( 4 ) S99 - S99 2019年11月

Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1. 査読国際誌

Ohtsuki T, Shinaoka A, Kumagishi-Shinaoka K, Asano K, Hatipoglu OF, Inagaki J, Takahashi K, Oohashi T, Nishida K, Naruse K, Hirohata S

Experimental cell research 383 ( 2 ) 111556 - 111556 2019年10月

関節リウマチ前足部手術に対する術式別の臨床成績の比較

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 木曽洋平, 松橋美波, 尾崎敏文

中国・四国整形外科学会雑誌 31 ( 3 ) 322 - 322 2019年10月

DARTS人工手関節の短期成績

松橋美波, 西田圭一郎, 渡辺雅仁, 沖田駿治, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

中国・四国整形外科学会雑誌 31 ( 3 ) 321 - 321 2019年10月

関節超音波画像を用いた人工知能教育システムの報告

中原龍一, 長谷井嬢, 渡辺雅仁, 松橋美波, 木曽洋平, 那須義久, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 31 ( 3 ) 396 - 396 2019年10月

人工肘関節置換術後ゆるみを生じていた上腕骨コンポーネント周囲骨折に対し内固定術を行った1例

沖田駿治, 西田圭一郎, 松橋美波, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

中国・四国整形外科学会雑誌 31 ( 3 ) 348 - 348 2019年10月

趾用Swansonインプラントを用いた母指MP関節形成術後29年経過した1例

沖田駿治, 石川肇, 阿部麻美, 谷口慎治, 黒澤陽一, 長谷川絵理子, 伊藤聡, 大谷博, 中園清, 村澤章, 西田圭一郎, 尾崎敏文

日本関節病学会誌 38 ( 3 ) 298 - 298 2019年10月

RA外側足趾に対する治療戦略関節リウマチによる外側趾変形に対する中足骨遠位短縮骨切り術(スクリュー固定)

那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 38 ( 3 ) 232 - 232 2019年10月

関節リウマチに対する人工指関節置換術の臨床成績関節リウマチのMCP関節に対するシリコンインプラント形成術の臨床成績

西田圭一郎, 松橋美波, 木曽洋平, 沖田駿治, 渡辺雅仁, 中原龍一, 那須義久, 尾崎敏文

日本関節病学会誌 38 ( 3 ) 169 - 169 2019年10月

関節超音波画像を用いた人工知能研究システムの開発

中原龍一, 西田圭一郎, 松橋美波, 渡辺雅仁, 木曽洋平, 那須義久, 尾崎敏文

日本関節病学会誌 38 ( 3 ) 156 - 156 2019年10月

舟状骨偽関節に対して低侵襲手術により加療した一例

齋藤太一, 松橋美波, 内野崇彦, 島村安則, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 31 ( 2 ) 268 - 268 2019年9月

軟骨細胞によるIL-1β誘導性蛋白分解酵素発現に対する脂肪由来抽出液の影響とその機序

大橋秀基, 西田圭一郎, 佐伯正典, 那須義久, 中原龍一, 木曽洋平, 渡辺雅仁, 松橋美波, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1933 - S1933 2019年9月

関節リウマチモデルマウスを用いたCD30阻害療法の検討

松橋美波, 西田圭一郎, 渡辺雅仁, 木曽洋平, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1850 - S1850 2019年9月

腱骨接合部の恒常性におけるメカニカルストレスの影響

斎藤太一, 根津智史, 松橋美波, 吉田晶, 島村安則, 古松毅之, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1693 - S1693 2019年9月

関節リウマチの滑膜細胞増殖におけるADAM12の役割とmiRNA-29bによる制御

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 大橋秀基, 木曽洋平, 沖田駿治, 松橋美波, 尾崎敏文

日本整形外科学会雑誌 93 ( 8 ) S1740 - S1740 2019年9月

RA 手のリハビリテーション

松山宜之, 中原龍一, 那須義久, 西田圭一郎

臨床リウマチ 31 ( 3 ) 259 - 265 2019年9月

Tuberosity-overlapping Fixation of the Humeral Shaft in Humeral Head Replacement Surgery.

Takaaki Hiranaka, Keiichiro Nishida, Taizo Konishiike, Toshifumi Ozaki, Motohiko Mikasa

Acta medica Okayama 73 ( 4 ) 299 - 305 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

The fixation technique of bony fragments is crucial for the bone union of the tuberosities after humeral head replacement (HHR) for a comminuted fracture of the proximal humerus. To increase the bone union rate, we reduce tuberosities to overlap on the humeral shaft by approx. 1 cm and fix them with cable wire. Herein, we retrospectively investigated the clinical and radiographic outcomes of our procedure. Twenty-six patients who underwent cementless HHR for the treatment of comminuted fractures of the proximal humerus were investigated. The Constant-Murley score, active shoulder mobility, and bone union rate were evaluated. The mean duration of follow-up was 56.3 months (range 24-197). At the final follow-up, the average Constant-Murley score was 58 (range 40-76). Forward elevation was 126° on average (range 35°-180°). Twenty-three cases (88%) showed bone union between the tuberosities and the shaft at an average follow-up of 4.1 months (range 4-5 months) after surgery. Non-union was noted in 1 case, and bone resorption was noted in 2 cases. The bone union rate and the clinical outcome of our procedure were relatively favorable.

DOI： 10.18926/AMO/56931

慢性腰痛に対する「本音の」治療戦略慢性腰痛に対する集学的アプローチ

リウマチ肩関節外科の現状と将来展望解剖学的人工肩関節全置換術

西田圭一郎, 那須義久, 中原龍一, 尾崎敏文

関節の外科 46 ( 2 ) 40 - 40 2019年8月

リウマチ肘における手術適応、手術法と将来展望 Unlinked TEAの利点と限界

那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 中原龍一, 西田圭一郎, 尾崎敏文

関節の外科 46 ( 2 ) 51 - 51 2019年8月

Involvement of ADAM12 in Chondrocyte Differentiation by Regulation of TGF-β1-Induced IGF-1 and RUNX-2 Expressions. 査読国際誌

Horita M, Nishida K, Hasei J, Furumatsu T, Sakurai M, Onodera Y, Fukuda K, Salter DM, Ozaki T

Calcified tissue international 105 ( 1 ) 97 - 106 2019年7月

鉄永倫子, 西田圭一郎, 鉄永智紀, 井上真一郎, 太田晴之, 大倉和代, 宮本和子, 尾崎敏文

PAIN RESEARCH 34 ( 2 ) 120 - 120 2019年7月

半月板からみた早期OAの予防と進行抑制

古松毅之, 西田圭一郎, 尾崎敏文

日本関節病学会誌 38 ( 2 ) 85 - 90 2019年7月

Prevalence of and Risk Factors for the Progression of Upper Cervical Lesions in Patients with Rheumatoid Arthritis.

Masahiro Horita, Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Sugimoto, Yoshihisa Nasu, Ryuichi Nakahara, Ryozo Harada, Toshifumi Ozaki

Acta medica Okayama 73 ( 3 ) 235 - 240 2019年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

We investigated the prevalence of and risk factors for the progression of upper cervical lesions (UCLs) in patients with rheumatoid arthritis (RA). A retrospective analysis of 49 patients with RA (4 males, 45 females) was conducted. The UCLs included atlanto-axial subluxation and vertical subluxation. We investigated the clinical factors including the Disease Activity Score 28 based on C-reactive protein (DAS28-CRP) and the modified Health Assessment Questionnaire-Disability Index as well as radiographic changes between the baseline (at May 2010 to April 2013) and final follow-up. Forty patients (81.6%) were classified as the non-progressive group, and the other 9 patients (18.4%) comprised the progressive group. The progressive group's final CRP values, baseline or final MMP-3 levels, DAS28-CRP, and rate of pre-existing lesions at baseline were all significantly higher than those of the non-progressive group (p=0.017, p=0.043, p=0.002, p=0.008, p<0.001, and p=0.008 respectively). A multivariate logistic regression analysis demonstrated that DAS28-CRP at baseline was a risk factor for radiographic progression (p=0.018, odds ratio: 2.54, 95% confidence interval: 1.17-5.51). Our findings indicate that higher disease activity might influence the progression of UCLs in patients with RA.

DOI： 10.18926/AMO/56866

岡山大学病院における運動器慢性痛患者に対する復職支援の取り組み

慢性疼痛患者の集学的治療における活動能力の経時的変動と特徴に関する基礎的検討

太田晴之, 齋藤圭介, 鉄永倫子, 堅山佳美, 西田圭一郎, 千田益生, 尾崎敏文

運動器リハビリテーション 30 ( 2 ) 216 - 216 2019年6月

当院における人工肘関節置換術後の可動域訓練プログラム

松山宜之, 那須義久, 中原龍, 西田圭一郎, 尾崎敏文

運動器リハビリテーション 30 ( 2 ) 204 - 204 2019年6月

Rasch分析を用いたRA患者における上肢機能評価の検討

原田遼三, 西田圭一郎, 那須義久, 中原龍一

運動器リハビリテーション 30 ( 2 ) 238 - 238 2019年6月

ビスフォスフォネート製剤長期服用者に生じた尺骨非定型骨折の4例

沖田駿治, 斉藤太一, 松橋美波, 横尾賢, 望月雄介, 兼田大輔, 山本乃利男, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O23 - 6 2019年4月

日本外傷データバンクからみる近年の日本における上肢切断に対する治療の傾向

斎藤太一, 沖田駿治, 松橋美波, 山川泰明, 湯本哲也, 島村安則, 西田圭一郎, 中尾篤典, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O22 - 1 2019年4月

関節リウマチに対する小指MP人工指関節置換術の治療成績

松橋美波, 那須義久, 木曽洋平, 斎藤太一, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 36 ( 1 ) O34 - 3 2019年4月

その他の医原性免疫不全関連リンパ増殖性疾患

佐藤康晴, 祇園由佳, 西田圭一郎, 吉野正

病理と臨床 37 ( 4 ) 360 - 363 2019年4月

サルコイドーシスの手指関節病変に対して外科的治療を行った2例

松橋美波, 那須義久, 中原龍一, 西田圭一郎

岡山医学会雑誌 131 ( 1 ) 61 - 61 2019年4月

RA手術によるQOL向上のエビデンス QOLを高める手術のエビデンス肩・肘

那須義久, 原田遼三, 西田圭一郎, 松橋美波, 渡辺雅仁, 沖田駿治, 木曽洋平, 大橋秀基, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 223 - 223 2019年3月

関節リウマチ患者に対する連結型人工肘関節全置換術(PROSNAP)の臨床成績の検討

沖田駿治, 西田圭一郎, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 638 - 638 2019年3月

関節リウマチ診断における両手足造影MRI検査の有用性の検討

松橋美波, 中原龍一, 渡辺雅仁, 沖田駿治, 木曽洋平, 那須義久, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 611 - 611 2019年3月

関節リウマチの滑膜細胞増殖におけるADAM12の役割とmiRNA-29bによる制御

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 大橋秀基, 沖田駿治, 木曽洋平, 松橋美波, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 743 - 743 2019年3月

関節リウマチ手術後のPRO(ボディイメージ・抑うつ・機能)の改善は術前の疾患活動性に影響される

小橋靖子, 西田圭一郎, 堀田昌宏, 那須義久, 雑賀建多, 中原龍一, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 659 - 659 2019年3月

軟骨組織に対する濃縮脂肪由来抽出液の影響

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 尾崎敏文

移植 53 ( 6 ) 379 - 379 2019年3月

鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 93 ( 3 ) S1259 - S1259 2019年3月

関節リウマチ前足部変形における外側趾中足骨短縮骨切りが外反母趾角に与える影響

那須義久, 松橋美波, 沖田駿治, 木曽洋平, 渡辺雅仁, 大橋秀基, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 93 ( 3 ) S1115 - S1115 2019年3月

結晶誘発性関節炎・痛風超音波ガイド下穿刺が診断治療に有用であった股関節偽痛風の2例

原田遼三, 西田圭一郎, 中原龍一, 那須義久, 高杉幸司, 藤森美鈴, 江澤和彦, 藤田慎一朗, 井上貴絵, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 63回 547 - 547 2019年3月

変形性関節症:from bench to bedside 関節軟骨のバイオイメージング

大橋俊孝, 加来田博貴, 大野充昭, 西田圭一郎

日本整形外科学会雑誌 93 ( 2 ) S331 - S331 2019年3月

Dupuytren拘縮に対する部分腱膜切除術の術後成績

齋藤太一, 島村安則, 松橋美波, 内野崇彦, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 35 ( 5 ) 898 - 901 2019年2月

記述言語：日本語出版者・発行元：(一社)日本手外科学会

Dupuytren拘縮に対して長軸切開にて部分手掌腱膜切除を行い,Z形成を追加して閉創を行った症例と,Zigzag切開にて部分手掌腱膜切除を行った症例について治療成績を比較検討した.2年以上追跡可能であった病的腱膜切除を施行した17例22指を対象とした.最終観察時の平均屈曲拘縮角度はZigzag切開を行った症例群では術前61.1度から術後27.8度へ,長軸切開を行った症例群では術前87.7度から術後21.2度へと,どちらも術前に比べ有意な改善を認めた.DASHスコアについてもZigzag切開を行った群では術前10.3から術後1.5へ,長軸切開を行った群では術前6.3から術後1.2へとどちらも術前に比べ有意な改善を認めた.Zigzag切開を行った症例のうち2年後再発により再手術した症例を1例認め,長軸切開にてアプローチした症例のうちで皮膚移植を行った症例を1例認めた.術後に創離開や皮膚壊死を生じた例は認められなかった.両アプローチとも,中程度から高度屈曲拘縮例においても安定した中期成績を示した.長軸切開にZ形成を追加する術式はアプローチにしやすさという点から有用と思われた.(著者抄録)

関節リウマチ患者の高度拘縮肘に対する人工肘関節置換術

松橋美波, 那須義久, 沖田駿治, 木曽洋平, 西田圭一郎, 尾崎敏文

日本肘関節学会雑誌 26 ( 1 ) S141 - S141 2019年2月

50歳未満の関節リウマチ患者に行った人工肘関節全置換術の臨床成績の検討

沖田駿治, 西田圭一郎, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 中原龍一, 那須義久, 尾崎敏文

日本肘関節学会雑誌 26 ( 1 ) S138 - S138 2019年2月

小児整形外科における最新の超音波診断

青木清, 西田圭一郎, 赤澤啓史, 寺本亜留美

整形・災害外科 62 ( 1 ) 43 - 51 2019年1月

Clinical features and treatment outcome of desmoid-type fibromatosis: based on a bone and soft tissue tumor registry in Japan 査読

Nishida Y, Kawai A, Toguchida J, Ogose A, Ae K, Kunisada T, Matsumoto Y, Matsunobu T, Takahashi K, Nishida K, Ozaki T

International Journal of Clinical Oncology 24 1498 - 1505 2019年

High molecular weight hyaluronan protects cartilage from degradation by inhibiting aggrecanase expression. 査読国際誌

Takashi Ohtsuki, Keiichi Asano, Junko Inagaki, Akira Shinaoka, Kanae Kumagishi-Shinaoka, Mehmet Z Cilek, Omer F Hatipoglu, Toshitaka Oohashi, Keiichiro Nishida, Issei Komatsubara, Satoshi Hirohata

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 36 ( 12 ) 3247 - 3255 2018年12月

記述言語：英語

Hyaluronan (HA) is an extracellular matrix (ECM) component of articular cartilage and has been used to treat patients with osteoarthritis (OA). A disintegrin and metalloproteinases with thrombospondin motifs (ADAMTSs) play an important role in cartilage degradation in OA. We have previously reported that ADAMTS4 and ADAMTS9 were induced by cytokine stimulation. However, the effect of HA on the cytokine-inducible ADAMTS9 has never been investigated. Moreover, it is unclear whether HA protects cartilage by suppressing aggrecan degradation. Here, we examined the effects of HA on ADAMTS expression in vitro and on cartilage degradation in vivo. ADAMTS9 expression was higher than that of the other aggrecanases (ADAMTS4 and 5) in human chondrocytes, chondrocytic cells, and rat cartilage. ADAMTS4 and 9 mRNA levels were upregulated in cytokine-stimulated chondrocytes and chondrocytic cells. Pre-incubation with HA significantly inhibited ADAMTS9 mRNA expression in cytokine-stimulated cells. In a rat OA model, Adamts5 and 9 mRNA levels were transiently increased after surgery; intra-articular HA injections attenuated the induction of Adamts5 and 9 mRNA. HA also blocked aggrecan cleavage by aggrecanase in OA rats in a molecular size-dependent manner. These results demonstrate that HA attenuates induced aggrecanases expression in OA and thereby protects articular cartilage degradation by this enzyme. Our findings provide insight into the molecular basis for the beneficial effects of HA in OA. © 2018 The Authors. Journal of Orthopaedic Research® Published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society. J Orthop Res 36:3247-3255, 2018.

DOI： 10.1002/jor.24126

関節リウマチに対する尺骨遠位端切除術を併用した手関節部分固定術の中・長期治療成績

竹下歩, 西田圭一郎, 那須義久, 沖田駿治, 橋詰博行, 尾崎敏文

日本手外科学会雑誌 35 ( 3 ) 434 - 436 2018年12月

記述言語：日本語出版者・発行元：(一社)日本手外科学会

関節リウマチに対する尺骨遠位端切除術を併用した手関節部分固定術の治療成績を検討した.術後5年以上経過観察可能であった19例23手を対象とした.症例は全て女性で,手術時年齢は平均50.7歳,経過観察期間は平均9.9年であった.手術は橈骨月状骨間固定術が21手,橈骨月状骨三角骨間固定術が2手であり,術前のSchulthess分類はType IIが15手,Type IIIが8手であった.良好な除痛効果と手関節アライメントの矯正・維持が獲得されていた.最終調査時には掌背屈可動域に減少を認めたが,術後月状骨周囲に骨性硬直を生じた群で顕著であり,その頻度はSchulthess分類Type IIIの手関節で高かった.そのため手根中央関節の破壊が高度である場合は,手関節部分固定術後に月状骨周囲骨性強直が発生し,手関節アライメント異常の矯正は獲得される一方で,掌背屈可動域減少が生じる可能性が高いと考える.(著者抄録)

【腰痛治療の最前線】腰痛の治療腰痛のリエゾン療法

鉄永倫子, 西田圭一郎, 鉄永智紀, 尾崎敏文

関節外科 37 ( 12 ) 1350 - 1356 2018年12月

記述言語：日本語出版者・発行元：(株)メジカルビュー社

腰痛に対する保存療法、薬物療法、手術療法が進歩するなかで、認知行動学的な集学的治療の重要性も昨今認識されてきている。そこで、腰痛のリエゾン療法についての効果・限界・今後の展望について紹介する。(著者抄録)

プレガバリンの処方実態調査腎機能と用法・用量を基にした適正使用に関する考察

神崎浩孝, 鉄永倫子, 田中雄太, 槇田崇志, 西原茂樹, 鉄永智紀, 北村佳久, 西田圭一郎, 千堂年昭

Journal of Musculoskeletal Pain Research 10 ( 3 ) S153 - S153 2018年11月

【慢性運動器疼痛整形外科のペインマネジメント徹底解説】慢性運動器疼痛治療における薬学管理の実践ポイント! 慢性運動器疼痛治療薬の副作用マネジメント

神崎浩孝, 鉄永倫子, 西田圭一郎, 千堂年昭

薬局 69 ( 12 ) 3361 - 3367 2018年11月

記述言語：日本語出版者・発行元：(株)南山堂

＜Key Points＞◎慢性疼痛の治療は、個人差の大きいことから、その背景を十分に理解した上で、個別化した治療(医療)を提供する必要がある。◎慢性疼痛治療の目標は、「ADLとQOLの改善」であり、「痛みゼロ」を最重要目標としていない点でがん性疼痛治療と大きく異なっている。◎薬物療法マネジメントにおいて、薬剤使用の見極め(減量、中止や別の薬への変更)と副作用の発現リスクへの配慮が重要である。◎副作用マネジメントにおいて、漫然とした処方継続の回避と定期的な血液検査の奨励が必須である。◎高齢で慢性疼痛を呈する患者も多く、高齢者は副作用リスクも高いことから注意が必要である。(著者抄録)

岡山大学病院における運動器慢性痛患者に対する復職支援の取り組み

鉄永倫子, 西田圭一郎, 鉄永智紀, 井上真一郎, 松崎孝, 太田晴之, 神崎浩孝, 大倉和代, 石橋京子, 宮本和子

Journal of Musculoskeletal Pain Research 10 ( 3 ) S74 - S74 2018年11月

Drug dependence in patients with chronic pain: A retrospective study. 査読国際誌

Tetsunaga T, Tetsunaga T, Nishida K, Kanzaki H, Misawa H, Takigawa T, Shiozaki Y, Ozaki T

Medicine 97 ( 40 ) e12748 2018年10月

リウマチ足の治療成績を左右する因子関節リウマチ患者の前足部変形に対する手術における術式選択と治療成績の検討

堀田昌宏, 西田圭一郎, 橋詰謙三, 那須義久, 雑賀建多, 中原龍一, 大橋秀基, 林充, 尾崎敏文

日本足の外科学会雑誌 39 ( Suppl. ) S286 - S286 2018年10月

【しびれ・痛みに対する整形外科診療の進歩】薬物療法セロトニン・ノルアドレナリン再取り込み阻害薬の使用方法効果は抑うつの有無により影響するか

鉄永倫子, 鉄永智紀, 西田圭一郎, 尾崎敏文

別冊整形外科 ( 74 ) 23 - 26 2018年10月

関節リウマチに対するMCP関節人工関節置換術中に手関節部での腱処置剥離術を要した症例の検討

木曽洋平, 那須義久, 松橋美波, 渡辺雅仁, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 199 - 199 2018年10月

人工肘関節全置換術(TEA)術後の肘関節機能回復のアプローチとその角度変化

松山宜之, 中原龍一, 鍋倉由佳, 小川加苗, 藤岡晃, 岡佳純, 那須義久, 堅山佳美, 西田圭一郎, 千田益生

日本RAのリハビリ研究会誌 32 ( 1 ) 43 - 46 2018年10月

関節リウマチ外側趾MTP関節背屈変形の重症度分類

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 雑賀建多, 堀田昌宏

日本足の外科学会雑誌 39 ( Suppl. ) S370 - S370 2018年10月

関節リウマチにおけるPDスコアの関節破壊予測能の検討

沖田駿治, 中原龍一, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 那須義久, 西田圭一郎, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 306 - 306 2018年10月

深層学習を用いた超音波画像の関節部位推定

中原龍一, 西田圭一郎, 沖田駿治, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 那須義久, 野田知之, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 305 - 305 2018年10月

RA手の障害に対する手指人工関節における角速度の術後経過

松山宜之, 中原龍一, 松岡玲衣, 藤岡晃, 鍋倉由佳, 小川加苗, 岡佳純, 那須義久, 堅山佳美, 西田圭一郎, 千田益生, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 271 - 271 2018年10月

人工手関節全置換術(TWA)を受ける関節リウマチ患者の看護

小橋靖子, 西田圭一郎, 宮地亜美, 鍋倉由佳, 藤岡晃, 那須義久, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 216 - 216 2018年10月

関節リウマチに対するAVANTAとAVANTA preflexによる小指MP人工指関節置換術の治療成績

松橋美波, 那須義久, 渡辺雅仁, 沖田駿治, 木曽洋平, 大橋秀基, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 37 ( 3 ) 216 - 216 2018年10月

人工肘関節置換術施行後に隣接関節の運動機能が変化し追加にて「排泄動作自立」の目標設定が可能となった一症例

藤岡晃, 鍋倉由佳, 小川加苗, 松山宜之, 岡佳純, 中原龍一, 那須義久, 西田圭一郎, 千田益生

日本RAのリハビリ研究会誌 32 ( 1 ) 47 - 50 2018年10月

短母指伸筋腱の停止様式が母指ボタン穴変形発症に与える影響

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 尾崎敏文, 中原龍一, 那須義久

中国・四国整形外科学会雑誌 30 ( 2 ) 291 - 291 2018年9月

関節リウマチによる高度手関節破壊に対して人工手関節置換術を施行した2例

那須義久, 中原龍一, 西田圭一郎, 尾崎敏文

中部日本整形外科災害外科学会雑誌 61 ( 秋季学会 ) 249 - 249 2018年9月

A Multidisciplinary Approach to the Management of Chronic Pain through a Self-managed Behavioral Exercise Program : A Pilot Study in Japan. 査読

Nishie H, Tetsunaga T, Kanzaki H, Oda K, Inoue S, Ryuo Y, Ota H, Miyawaki T, Arakawa K, Tetsunaga T, Kitamura Y, Sendo T, Morimatsu H, Ozaki T, Nishida K

Acta medica Okayama 72 ( 4 ) 343 - 350 2018年8月

濃縮脂肪由来抽出液によるOAモデルラットの軟骨破壊抑制とその機序の解明

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 松橋美波, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S2018 - S2018 2018年8月

超音波診療の進歩のための基礎研究超音波3D評価

中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S1712 - S1712 2018年8月

LT-α刺激による軟骨細胞由来RANKLの発現亢進と破骨細胞分化促進効果

竹下歩, 西田圭一郎, 那須義久, 中原龍一, 兼田大輔, 大橋秀基

日本整形外科学会雑誌 92 ( 8 ) S1659 - S1659 2018年8月

高度の緩みを有する人工肘関節周囲骨折に対して骨接合術を施行した1例

沖田駿治, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

岡山医学会雑誌 130 ( 2 ) 99 - 99 2018年8月

関節リウマチ下肢手術において止血帯が無効であった症例の検討

原田遼三, 西田圭一郎, 那須義久, 棗田将光, 藤森美鈴, 高杉幸司, 斎藤大輔, 江澤和彦, 竹本美由紀, 藤田慎一朗, 山本渉

岡山医学会雑誌 130 ( 2 ) 99 - 99 2018年8月

関節リウマチにおける手指・手関節の超音波PDスコアと関節破壊の関連

沖田駿治, 中原龍一, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 那須義久, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 92 ( 8 ) S2052 - S2052 2018年8月

リウマチ性疾患治療中に発症し診断に難渋した手指屈筋腱腱鞘滑膜炎の3例

沖田駿治, 那須義久, 松橋美波, 渡辺雅仁, 木曽洋平, 大橋秀基, 中原龍一, 西田圭一郎, 尾崎敏文

日本骨・関節感染症学会プログラム・抄録集 41回 126 - 126 2018年7月

関節リウマチ前足部手術における術式別のTUGおよびJSSF-RA scaleの検討とX線学的解析

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 大橋秀基, 木曽洋平, 沖田駿治, 松橋美波, 尾崎敏文

関節の外科 45 ( 2 ) 96 - 96 2018年7月

生物学的製剤使用下における上肢手術〜現状と今後の展望〜生物学的製剤使用下の関節リウマチ手関節・手指手術の傾向

那須義久, 西田圭一郎

関節の外科 45 ( 2 ) 38 - 38 2018年7月

The role of lymphotoxin-α in rheumatoid arthritis

Tomohiro Hirose, Yuri Fukuma, Ayumu Takeshita, Keiichiro Nishida

Inflammation Research 67 ( 6 ) 495 - 501 2018年6月

記述言語：英語出版者・発行元：Birkhauser Verlag AG

Background: The role of tumor necrosis factor (TNF) in the inflammatory response in rheumatoid arthritis (RA) is well established, whereas less is known about the role of TNF’s close homolog, lymphotoxin alpha (LTα). Findings: Increased levels of LTα are found in the serum and synovial tissue of patients with RA, and in vitro studies found that LTα-induced proliferation of RA fibroblast-like synoviocytes was at a similar level to TNF. These findings support the idea that anti-LTα treatment could be beneficial in patients with RA, but pateclizumab, an anti-LTα antibody, was not as efficacious as the anti-TNF agent adalimumab in reducing symptoms of RA in a head-to-head study, suggesting that anti-LTα therapies might not represent a valid alternative treatment option in patients with RA. However, suppression of LTα activity might be relevant in the context of RA-related comorbidities, as patients with RA have an increased risk of myocardial infarction (MI) compared with the general population, and specific polymorphisms of the LTα gene have been linked to increased MI risk. Conclusions: In this review, we summarize the key characteristics of LTα and the most recent findings on the role of LTα in RA.

DOI： 10.1007/s00011-018-1139-6

SETTING TREATMENT TARGET FOR JOINT SURGERY IN LOWER LIMBS IN PATIENTS WITH LONG-STANDING RHEUMATOID ARTHRITIS BASED ON MULTICENTER PROSPECTIVE COHORT STUDY; VALIDATION AND RELIABILITY OF OBJECTIVE INDEX OF ACTIVITY SPEED, TIMED UP AND GO TEST, FOR MEASURI

Kojima T, Ishikawa H, Tanaka S, Haga N, Nishida K, Yukioka M, Hashimoto J, Miyahara H, Niki Y, Kimura T, Oda H, Funahashi K, Asai S, Kojima M, Ishiguro N

ANNALS OF THE RHEUMATIC DISEASES 77 1333-1334 2018年6月

Characteristics of functional impairment in patients with long-standing rheumatoid arthritis based on range of motion of joints: Baseline data from a multicenter prospective observational cohort study to evaluate the effectiveness of joint surgery in the treat-to-target era 査読

Toshihisa Kojima, Hajime Ishikawa, Sakae Tanaka, Nobuhiko Haga, Keiichiro Nishida, Masao Yukioka, Jun Hashimoto, Hisaaki Miyahara, Yasuo Niki, Tomoatsu Kimura, Hiromi Oda, Shuji Asai, Koji Funahashi, Masayo Kojima, Naoki Ishiguro

Modern Rheumatology 28 ( 3 ) 474 - 481 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Taylor and Francis Ltd

Objective: To explore the characteristics of functional impairment in patients with established rheumatoid arthritis (RA) based on the range of motion (ROM) of joints in a prospective observational study of RA patients undergoing joint surgery. Methods: We collected data on demographics, Health Assessment Questionnaire Disability Index (HAQ-DI), and the ROM of large joints including the shoulder, elbow, wrist, hip, knee, and ankle. Associations between the ROM of each joint and disability in the eight HAQ-DI categories were determined using receiver operating characteristic (ROC) and logistic regression analyses. ROM cut-off values of each joint for the absence of disability in each HAQ-DI category were determined using ROC curves. Results: A total of 460 patients were enrolled and analyzed in this study. Based on ROC analysis, the ROM of each joint was significantly associated with disability in each category. After adjusting for disease activity, age, and sex, shoulder abduction had the highest independent impact on disability in activity [cut-off: 139 degrees (OR: 5.26)], elbow flexion-extension in dressing [121 degrees (OR: 2.22)], wrist flexion-extension in reach [86 degrees (OR: 2.71)], hip flexion-extension in walking [126 degrees (OR: 3.42)], and knee flexion-extension in walking [134 degrees (OR: 2.97)]. Conclusions: Limited ROM of multiple joints was significantly associated with functional impairment in patients with long-standing RA. Motion in daily activity involves multiple joints, and at least two joints were independently involved in disability.

DOI： 10.1080/14397595.2017.1349593

IL-6 is an independent predictive factor of drug survival after dose escalation of infliximab in patients with rheumatoid arthritis 査読

Koji Takasugi, Keiichiro Nishida, Masamitsu Natsumeda, Misuzu Yamashita, Wataru Yamamoto, Kazuhiko Ezawa

Modern Rheumatology 28 ( 3 ) 452 - 460 2018年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Taylor and Francis Ltd

Objective: We aimed to investigate factors predictive of increased serum infliximab (IFX) concentration with improvement of disease activity, as well as better 1-year continuation rate after dose escalation, in patients with rheumatoid arthritis (RA) who showed inadequate response to 3 mg/kg IFX. Methods: Among 42 patients allotted to receive 3 mg/kg IFX, 13 patients showed adequate response (DAS28 &lt
3.2) and 29 patients required dose escalation to 4.5 or 6 mg/kg after inadequate response (DAS28 ≥ 3.2) to 3 mg/kg IFX. DAS28, mHAQ, serum level of CRP, interleukin (IL)-6, IL-17, anti-infliximab antibody (AIA) titers and IFX concentration before and on average 2.7 months after dose escalation were examined to explore the baseline factors predictive of a clinically beneficial increase of serum IFX concentration and drug survival. Results: One year after IFX dose escalation, 25 patients completed the study protocol, and 16 patients (64%) continued to show a good response for one year, while 9 patients (36%) required switching of biologics because of inadequate response. Multivariate analyses revealed that a serum IL-6 level of less than 4.0 pg/mL at baseline was the only factor predictive of a clinically beneficial increase of serum IFX concentration in patients who required dose escalation. Receiver operating characteristic analysis revealed that 5.16 pg/mL of IL-6 was the cut-off value with sensitivity 0.833 and specificity of 0.769 (95%CI for AUC: 0.712–1.006). In patients with IL-6 levels of less than 5.16 pg/mL at baseline, the serum IFX concentration significantly increased after dose escalation with adequate response. The 1-year drug survival rates of patients with IL-6 levels less than 5.16 pg/mL and in those with levels greater than or equal to 5.16 pg/mL at baseline were 83.3% and 30.8%, respectively (log-rank test, p =.011). Conclusions: The results of our study indicated that a baseline serum level of IL-6 below 5.16 pg/mL might be a predictive factor for a clinically beneficial increase of serum IFX concentration with improvement of disease activity and better 1-year continuation rate after IFX dose escalation.

DOI： 10.1080/14397595.2017.1361802

RAにおける大関節破壊の予測と評価関節リウマチの罹病期間・疾患活動性と関節破壊 modified Total Sharp ScoreとARASHI score

関節リウマチ患者のボディイメージに対する手術治療の影響

堀田昌宏, 西田圭一郎, 那須義久, 中原龍一, 林充, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 55 ( 特別号 ) 2 - 5 2018年5月

那須義久, 橋詰謙三, 西田圭一郎

日本整形外科学会雑誌 92 ( 5 ) 364 - 368 2018年5月

記述言語：日本語出版者・発行元：(公社)日本整形外科学会

生物学的製剤を投与中で、1年以上の間隔をあけて評価に必要な単純X線画像および臨床評価が得られた75例(平均62.6歳)を対象とした。調査期間中の大関節破壊の進行と患者背景との関係を調査するために、ARASHI change score(ACS)を大関節破壊進行群(ACS>0群)と非進行/改善群(ACS≦0群)の2群にわけて比較した。調査期間中、対象のCRP、modified Health assessment questionnaire(mHAQ)、DAS28-CRP、modified Total Sharp Score(mTSS)の平均値に有意な変化はなかった。調査開始時の平均mTSSとASSは、大関節と小関節の破壊の程度と有意な相関があった。ASSはDAS28-CRPなどの疾患活動性とは弱い有意な正の相関があった。最終調査時迄の変化はΔmTSSが平均2.25±9.93、ARASHI change score(ACS)が平均0.03±2.30であった。ACSで評価した大関節破壊の進行は16例(21.3%)に認めた。ACSはΔDAS28-CRP、ΔmHAQと有意な相関を示し、ACS>0群はACS≦0群よりも有意にΔDAS28-CRP、ΔCRP、ΔmHAQが高かった。

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J01133&link_issn=&doc_id=20180607020002&doc_link_id=%2Ffj2ortho%2F2018%2F009205%2F003%2F0364-0368%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffj2ortho%2F2018%2F009205%2F003%2F0364-0368%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

サルコイドーシスの関節病変に対して外科的治療を行なった2例

松橋美波, 那須義久, 渡辺雅仁, 斎藤太一, 島村安則, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 35 ( 1 ) S774 - S774 2018年4月

RAに対する手関節部分固定術の中・長期治療成績

竹下歩, 西田圭一郎, 島村安則, 那須義久, 斎藤太一, 中道亮, 沖田駿治, 尾崎敏文

日本手外科学会雑誌 35 ( 1 ) S220 - S220 2018年4月

Dupuytren拘縮の術後成績

斎藤太一, 島村安則, 中道亮, 竹下歩, 沖田駿治, 松橋美波, 岡崎勇樹, 西田圭一郎, 尾崎敏文

日本手外科学会雑誌 35 ( 1 ) S147 - S147 2018年4月

【運動器画像診療の最前線】部位別・疾患別画像診療の最前線関節リウマチの画像診療

中原龍一, 西田圭一郎

関節外科 37 ( 4月増刊 ) 106 - 119 2018年4月

記述言語：日本語出版者・発行元：(株)メジカルビュー社

＜画像診療のポイント＞●関節リウマチ診療においては、それぞれの画像検査の特徴と使いどころを知ることが重要である。●単純X線検査は最も基本的な画像検査であり、定期的に撮影すれば微小な変化の検出に役立つ。●MRIは骨髄浮腫や滑膜炎の診断が可能であるが、コストが高く造影剤投与が必要であるため、超音波検査との使い分けが必要である。●超音波検査は近年注目されている画像検査であり、外来で簡便に関節評価が可能であるため、使い方に習熟すべきである。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00282&link_issn=&doc_id=20180406150011&doc_link_id=10.18885%2FJ00282.2018192549&url=https%3A%2F%2Fdoi.org%2F10.18885%2FJ00282.2018192549&type=%88%E3%8F%91.jp_%83I%81%5B%83%8B%83A%83N%83Z%83X&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

Outcomes of Resection and Joint-Preserving Arthroplasty for Forefoot Deformities for Rheumatoid Arthritis 査読

Masahiro Horita, Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Nasu, Kenta Saiga, Ryuichi Nakahara, Takahiro Machida, Hideki Ohashi, Toshifumi Ozaki

Foot and Ankle International 39 ( 3 ) 292 - 299 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE Publications Inc.

Background: We investigated the clinical outcomes of resection and joint-preserving arthroplasty for forefoot deformities in patients with rheumatoid arthritis. Methods: Sixteen feet of 14 women (average age, 67.1 years
range, 53-82) underwent resection arthroplasty of the metatarsal head (resection group), and 18 feet of 15 women (average age, 61.3 years
range, 40-73) underwent a metatarsophalangeal joint-preserving procedure with shortening oblique metatarsal osteotomies of the lesser toes (joint preservation group). The mean disease duration in the resection and joint preservation groups was 23.6 and 19.1 years, and the average follow-up period was 37.3 and 33.5 months, respectively. The classification of Larsen was used to assess the severity of destruction of the metatarsophalangeal (MTP) joint. Preoperative and postoperative clinical evaluation included Japanese Society for Surgery of the Foot (JSSF) score and postoperative complications. Results: The number of preoperative radiographic destruction of the MTP joints (Larsen grade II, III, IV, and V) was 0, 29, 39, and 12 joints in the resection group and 13, 67, 9, and 1 joints in the joint preservation group. The mean JSSF score improved significantly from 61.3 to 83.9 points in the resection group (P &lt
.001) and from 62.2 to 90.8 points in the joint preservation group (P &lt
.001). In the resection group, recurrence of callosities and claw toe deformity was observed in 6 and 3 feet, respectively. In the joint-preserving group, recurrence of callosities and hammer toe deformity was observed in 1 foot each. Conclusion: The resection arthroplasty and joint-preserving procedure showed satisfactory clinical outcomes. However, whether both procedures can maintain the good clinical results without the recurrence of forefoot deformity will require longer follow-up. Level of Evidence: Level III, retrospective comparative series.

DOI： 10.1177/1071100717743996

単純X線足荷重位正面像における外側趾MTP関節背側脱臼の重症度スコア

関節リウマチの手術4:上肢・その他関節リウマチによる手指伸筋腱断裂症例の患者背景近年の傾向と薬物療法との関係

那須義久, 渡辺雅仁, 木曽洋平, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 586 - 586 2018年3月

関節リウマチ肘に対するLinked人工肘関節(PROSNAP)の臨床成績の検討

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 734 - 734 2018年3月

関節リウマチに対するMCP関節人工関節置換術中に手関節部での腱剥離術を要した症例の検討

木曽洋平, 那須義久, 渡辺雅仁, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 729 - 729 2018年3月

関節リウマチ患者におけるTimed UP and GO(TUG)testを用いた下肢機能、QOLの検討

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 江澤和彦, 高杉幸司, 藤森美鈴, 藤田慎一朗, 井上貴絵, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 710 - 710 2018年3月

関節リウマチの手術4:上肢・その他関節リウマチの手術が患者のボディイメージに与える影響

小橋靖子, 西田圭一郎, 堀田昌宏, 那須義久, 橋詰謙三, 中原龍一, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 587 - 587 2018年3月

関節リウマチの手術4:上肢・その他短母指伸筋腱の停止様式と母指ボタン穴変形との関連について

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 586 - 586 2018年3月

術後早期に復職できたが機能回復には長期間を要したRA患者の一症例

松山宜之, 坂口和輝, 鍋倉由佳, 小川加苗, 藤岡晃, 岡佳純, 堅山佳美, 西田圭一郎, 千田益生

作業療法おかやま 27 54 - 54 2018年3月

リウマチ性疾患の画像1:関節エコーRA 動画画像を教師画像とした深層学習を用いた関節リウマチ患者の超音波画像自動分類

中原龍一, 西田圭一郎, 木曽洋平, 沖田駿治, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 455 - 455 2018年3月

リウマチ上肢のリハビリと手術〜真の寛解を目指して〜リウマチ上肢のリハビリと手術人工肘関節置換術で社会的・精神的寛解をえられるか

西田圭一郎, 那須義久, 小橋靖子, 橋詰謙三, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 231 - 231 2018年3月

関節リウマチ患者のQOL向上を目指した薬物・手術のcombined therapy 疾患活動性からみた整形外科手術が患者Body Imageに与える影響

西田圭一郎, 小橋靖子, 堀田昌宏, 那須義久, 中原龍一, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 62回 220 - 220 2018年3月

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1169 - S1169 2018年3月

関節リウマチに対する手術加療の傾向初回手術例の患者背景

那須義久, 渡辺雅仁, 沖田駿治, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1041 - S1041 2018年3月

関節リウマチ前足部手術における術式別のTUGおよびJSSF-RA scaleの検討

渡辺雅仁, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 木曽洋平, 沖田駿治, 尾崎敏文

日本整形外科学会雑誌 92 ( 3 ) S1028 - S1028 2018年3月

関節リウマチ診療における超音波多関節評価・検査時間の短縮の研究

中原龍一, 西田圭一郎, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S313 - S313 2018年3月

短母指伸筋腱の停止様式が母指ボタン穴変形発症に与える影響

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本整形外科学会雑誌 92 ( 2 ) S175 - S175 2018年3月

アバタセプトは関節リウマチにおける周術期合併症を増やすか多施設コホート研究に基づく入れ子型ケースコントロール研究より

伊藤宣, 辻成佳, 中山政憲, 持田勇一, 西田圭一郎, 石川肇, 小嶋俊久, 松本卓巳, 窪田綾子, 望月猛, 桃原茂樹

日本整形外科学会雑誌 92 ( 3 ) S595 - S595 2018年3月

関節リウマチの自己血輸血関節リウマチに対する整形外科手術施行時の術前Hb値と疾患活動性、使用薬剤との関係

那須義久, 西田圭一郎

自己血輸血 31 ( 学術総会 ) S32 - S32 2018年2月

The clinical course of patients with rheumatoid arthritis who underwent orthopaedic surgeries under disease control by tofacitinib. 査読国際誌

Nishida K, Harada R, Nasu Y, Takeshita A, Nakahara R, Matsumeda M, Ozaki T

Modern rheumatology 28 ( 6 ) 1 - 8 2018年1月

Identification of specific protein markers of rheumatoid arthritis in synovial fluid and serum 査読

Keisuke Mihara, Sayuki Kohno, Shiho Hatanaka, Tsutomu Yamasaki, Kei-Ichiro Nishida, Tohru Nakanishi

Journal of Hard Tissue Biology 27 ( 1 ) 55 - 58 2018年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Society of Hard Tissue Regenerative Biology

Rheumatoid arthritis (RA) is a common articular disease characterized by chronic inf lammation, hyperproliferation of synovial cells, and bone destruction. Recently, we showed that small interfering RNA targeting CD81 (siCD81) is therapeutically effective for RA. CD81 belongs to a family of cell-surface proteins (tetraspanins) known to be up-regulated in RA synoviocytes, and siCD81 decreases the expression of synoviolin and TNF-α at the cellular level. We also previously established a highly sensitive sandwich ELISA system using monoclonal antibodies (MAbs) against CD81 by immunization with the outer membrane region of CD81 (LEL), which was overexpressed as a recombinant protein. This assay can be used to detect CD81 in synovial fluids and serum. Here, we identified several specific marker proteins and peptides for diagnosis of RA, including CD81 by using a protein chip system, 2D-gels, and western blotting. These markers can be used for early diagnosis of RA and might contribute to further effective treatment.

DOI： 10.2485/jhtb.27.55

Target setting for lower limb joint surgery using the Timed Up and Go test in patients with rheumatoid arthritis: A prospective cohort study

Mast cells exhibiting storong cytoplasmic staining for IgE and high affinity IgE receptor are increased in IgG4-related disease. 査読国際誌

Nishida K, Gion Y, Takeuchi M, Tanaka T, Kataoka RT, Yoshino T, Sato Y

Scientific Reports 8 ( 1 ) 4656 - 4656 2018年

Kojima, T., Ishikawa, H., Tanaka, S., Haga, N., Nishida, K., Yukioka, M., Hashimoto, J., Miyahara, H., Niki, Y., Kimura, T., Oda, H., Asai, S., Funahashi, K., Kojima, M., Ishiguro, N.

International Journal of Rheumatic Diseases 21 ( 10 ) 2018年

Mid-term results of alumina ceramic unlinked total elbow arthroplasty with cement fixation for patients with rheumatoid arthritis

Nishida, K., Hashizume, K., Nasu, Y., Ozawa, M., Fujiwara, K., Inoue, H., Ozaki, T.

Bone and Joint Journal 100B ( 8 ) 2018年

Inhibitory effect of JAK inhibitor on mechanical stress-induced protease expression by human articular chondrocytes 査読

Takahiro Machida, Keiichiro Nishida, Yoshihisa Nasu, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Masahiro Horita, Ayumu Takeshita, Daisuke Kaneda, Aki Yoshida, Toshifumi Ozaki

INFLAMMATION RESEARCH 66 ( 11 ) 999 - 1009 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER BASEL AG

To investigate whether janus kinase (JAK) inhibitor exhibits a chondro-protective effect against mechanical stress-induced expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) and matrix metalloproteinase (MMPs) in human chondrocytes.
Normal human articular chondrocytes were seeded onto stretch chambers and incubated with or without tofacitinib (1000 nM) for 12 h before mechanical stimulation or cytokine stimulation. Uni-axial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation, 30 min) was applied and the gene expression levels of type II collagen alpha 1 chain (COL2A1), aggrecan (ACAN), ADAMTS4, ADAMTS5, MMP13, and runt-related transcription factor 2 (RUNX-2) were examined by real-time polymerase chain reaction. Nuclear translocation of RUNX-2 and nuclear factor-kappa B (NF-kappa B) was examined by immunocytochemistry, and phosphorylation of mitogen-activated protein kinase (MAPK) and signaling transducer and activator of transcription (STAT) 3 was examined by western blotting. The concentration of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha in the supernatant was examined by enzyme-linked immunosorbent assay.
COL2A1 and ACAN gene expression levels were decreased by CTS, but these catabolic effects were canceled by tofacitinib. Tofacitinib significantly down-regulated CTS-induced expression of ADAMTS4, ADAMTS5, MMP13, and RUNX2, and the release of IL-6 in supernatant by chondrocytes. Tofacitinib also reduced CTS-induced nuclear translocation of RUNX-2 and NF-kappa B, and phosphorylation of MAPK and STAT3.
Tofacitinib suppressed mechanical stress-induced expression of ADAMTS4, ADAMTS5, and MMP13 by human chondrocytes through inhibition of the JAK/STAT and MAPK cascades.

DOI： 10.1007/s00011-017-1083-x

Integrating patients' perceptions into clinical practice guidelines for the management of rheumatoid arthritis in Japan. 査読国際誌

Masayo Kojima, Takeo Nakayama, Takashi Otani, Mieko Hasegawa, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern rheumatology 27 ( 6 ) 924 - 929 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Patients' values and preferences are among the key factors that determine the strength of recommendations presented in clinical practice guidelines (CPG). The aim of this study was to summarize the integration process for patients' perceptions into the development of CPG for rheumatoid arthritis (RA) management in Japan. METHODS: We used a mixed-methods approach. Questionnaires that could be self-administered were mailed to 2222 RA patients randomly selected from the Japan Rheumatism Friendship Association (JRFA) membership list that was age- and prefecture-stratified. A focus group with five JRFA executive members was formed to verify the results of the questionnaire. RESULTS: A total of 1470 patients aged 20-79 years old returned the questionnaire. Analysis of the questionnaire data revealed that the topics selected by the CPG task force met the patients' needs. The focus group participants showed reluctance to use the term 'preference' because patients would not want to take any medications but would have to take them out of necessity. CONCLUSIONS: We confirmed that the new CPG successfully addressed clinical issues that were important to both rheumatologists and patients. Clinicians should understand patients' reluctance to take medications and explain the role of each medication well to increase adherence.

DOI： 10.1080/14397595.2016.1276511

RA軟骨におけるRANKL発現とその誘導因子の検討

Rasch分析を用いたRA患者における上肢機能評価の検討

原田遼三, 西田圭一郎, 那須義久, 中原龍一, 兼田大輔, 竹下歩, 大橋秀基, 木曾洋平, 沖田駿治, 渡辺雅仁, 高杉幸司, 藤森美鈴, 江澤和彦

日本関節病学会誌 36 ( 3 ) 263 - 263 2017年10月

関節リウマチ肘に対するlinked人工肘関節(PROSNAP)の治療成績の検討

沖田駿治, 西田圭一郎, 渡辺雅仁, 木曽洋平, 大橋秀基, 兼田大輔, 竹下歩, 中原龍一, 那須義久, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 367 - 367 2017年10月

深層学習を用いた関節リウマチ患者の超音波画像分類における動画データ利用

中原龍一, 西田圭一郎, 木曽洋平, 大橋秀樹, 兼田大輔, 竹下歩, 那須義久, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 366 - 366 2017年10月

関節リウマチ新時代の手術療法 50歳未満のRA患者に対する人工肘関節全置換術

西田圭一郎, 沖田駿治, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 木曽洋平, 尾崎敏文, 橋詰謙三

日本関節病学会誌 36 ( 3 ) 362 - 362 2017年10月

中足骨遠位斜め骨切り短縮術を行った関節リウマチ外側趾のX線学的経時変化

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 360 - 360 2017年10月

関節リウマチ前足部手術における足長変化に関する検討

木曽洋平, 那須義久, 渡辺雅仁, 沖田瞬治, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 雑賀健多, 西田圭一郎, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 359 - 359 2017年10月

関節リウマチ前足部変形における外側趾中足骨短縮骨切りが外反母趾角に与える影響

那須義久, 渡辺雅仁, 木曽洋平, 沖田駿治, 大橋基広, 兼田大輔, 竹下歩, 中原龍一, 西田圭一郎, 尾崎敏文

日本関節病学会誌 36 ( 3 ) 358 - 358 2017年10月

外側型肘離断性骨軟骨炎に対する膝外側壁を含む骨軟骨柱移植術

島村安則, 内野崇彦, 名越充, 島村好信, 中道亮, 野田知之, 西田圭一郎, 尾崎敏文

日本肩関節学会抄録集 44回 161 - 161 2017年10月

関節リウマチ治療手術のタイミングと工夫リウマチ肘関節に対する人工関節置換術の適応とインプラント選択

那須義久, 西田圭一郎, 尾崎敏文

中部日本整形外科災害外科学会雑誌 60 ( 秋季学会 ) 55 - 55 2017年9月

竹下歩, 西田圭一郎, 那須義久, 中原龍一, 兼田大輔, 大橋秀基, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1515 - S1515 2017年8月

軟骨細胞によるIL-1β誘導性蛋白分解酵素発現に対する脂肪由来抽出液の影響

大橋秀基, 那須義久, 竹下歩, 兼田大輔, 木曽洋平, 沖田駿治, 渡辺雅仁, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1758 - S1758 2017年8月

メカニカルストレスによる軟骨細胞におけるRANKLの発現

兼田大輔, 西田圭一郎, 那須義久, 中原龍一, 堀田昌宏, 竹下歩, 大橋秀基, 沖田駿治, 木曽洋平, 渡辺雅仁, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1617 - S1617 2017年8月

軟骨分化制御による骨棘形成過程へのADAM12の関与

堀田昌宏, 西田圭一郎, 長谷井嬢, 古松毅之, 宮澤慎一, 那須義久, 中原龍一, 竹下歩, 兼田大輔, 大橋秀基, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1597 - S1597 2017年8月

深層学習を用いた自動学習に必要な教師画像数の検討関節リウマチ患者の単純X線画像の自動学習

中原龍一, 西田圭一郎, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 那須義久, 尾崎敏文

日本整形外科学会雑誌 91 ( 8 ) S1550 - S1550 2017年8月

関節リウマチ患者のボディイメージに対する手術治療の影響

堀田昌宏, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 林充, 尾崎敏文

関節の外科 44 ( 2 ) 67 - 67 2017年7月

足関節・足部最良の機能再建とQOL向上を目指して関節リウマチ前足部手術における足長変化に関する検討

木曽洋平, 那須義久, 渡辺雅仁, 沖田駿治, 大橋秀基, 竹下歩, 兼田大輔, 堀田昌宏, 中原龍一, 雑賀健多, 西田圭一郎, 尾崎敏文

関節の外科 44 ( 2 ) 36 - 36 2017年7月

空気圧迫止血帯が無効であった関節リウマチ下肢手術の2例

原田遼三, 西田圭一郎, 那須義久, 棗田将光, 藤森美鈴, 高杉幸司, 江澤和彦

関節の外科 44 ( 2 ) 79 - 79 2017年7月

Clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: Comparison of diffuse large B-cell lymphoma and classical Hodgkin lymphoma types 査読

Yuka Gion, Noriko Iwaki, Katsuyoshi Takata, Mai Takeuchi, Keiichiro Nishida, Yorihisa Orita, Tomoyasu Tachibana, Tadashi Yoshino, Yasuharu Sato

Cancer Science 108 ( 6 ) 1271 - 1280 2017年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Blackwell Publishing Ltd

Patients with rheumatoid arthritis often develop methotrexate-associated lymphoproliferative disorders (MTX-LPD) during MTX treatment. MTX-LPD occasionally regresses spontaneously after simply discontinuing MTX treatment. In patients without spontaneous regression, additional chemotherapy is required to avoid disease progression. However, the differences between spontaneous and non-spontaneous regression have yet to be elucidated. To clarify the factors important for spontaneous regression, we analyzed the clinicopathological features of 51 patients with rheumatoid arthritis who developed MTX-LPD (diffuse large B-cell lymphoma [DLBCL]-type [n = 34] and classical Hodgkin lymphoma [CHL]-type [n = 17]). We examined the interval from MTX discontinuation to the administration of additional chemotherapy. The majority of DLBCL-type MTX-LPD patients (81%) exhibited remission with MTX discontinuation alone. In contrast, the majority of CHL-type MTX-LPD patients (76%) required additional chemotherapy. This difference was statistically significant (P = 0.001). However, overall survival was not significantly different between DLBCL-type and CHL-type (91% vs 94%, respectively
P &gt
0.05). Thus, the morphological differences in the pathological findings of MTX-LPD may be a factor for spontaneous or non-spontaneous regression after discontinuation of MTX.

DOI： 10.1111/cas.13249

西田圭一郎, 小橋靖子, 鉄永倫子

Journal of Musculoskeletal Pain Research 9 ( 1 ) 7 - 14 2017年6月

記述言語：日本語出版者・発行元：(一社)日本運動器疼痛学会

関節リウマチ(RA)の治療は生物学的製剤の導入と新しい治療戦略により、過去14年で大きく変化した。近代のリウマチ治療は局所あるいは全身性の炎症抑制に傾注してきたが、一方で患者による全般的疾患活動性評価は、しばしば寛解達成のための障害因子であり、疼痛が最も影響を与える因子であることが知られている。RAにおける疼痛は炎症や、末梢性および中枢性の疼痛感作、抑うつ、関節の構造的変化など様々な機序によって引き起こされる。これらは疾患経過や炎症の沈静化と再燃、あるいは個人によって異なるが、それぞれに応じた適切な治療を選択しなければならない。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J05881&link_issn=&doc_id=20170707070001&doc_link_id=%2Feg5undok%2F2017%2F000901%2F004%2F0007-0014%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Feg5undok%2F2017%2F000901%2F004%2F0007-0014%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Short-term outcomes of patients being treated for chronic intractable pain at a liaison clinic and exacerbating factors of prolonged pain after treatment 査読

Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 22 ( 3 ) 554 - 559 2017年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Background: Although a multidisciplinary approach is often recommended to treat intractable pain, this approach does not completely prevent uncontrolled pain in some patients. The aim of this retrospective study was to investigate the exacerbating factors of prolonged, intractable pain among patients being treated at a pain liaison clinic.
Methods: The participants of this study were 94 outpatients (32 men, 62 women) with chronic intractable pain who visited our hospital between April 2013 and February 2015. Demographic and clinical information was obtained from all patients at baseline. Experts in various fields, including anesthesia, orthopedic surgery, psychiatry, physical therapy, and nursing, were involved in the treatment procedures. All patients were assessed before and after a 6-month treatment period using the following measures: the Numeric Rating Scale (NRS); the Pain Catastrophizing Scale (PCS); the Hospital Anxiety and Depression Scale (HADS); the Pain Disability Assessment Scale (PDAS); and the Oswestry Disability Index (ODI). All participants were then divided into two groups based on their self-reported pain after treatment: a pain relief group (n = 70) and a prolonged pain group (n = 24). The exacerbating factors of prolonged pain after treatment in the pain liaison outpatient clinic were analyzed using univariate and multiple logistic regression analysis.
Results: A significant improvement in NRS scores was observed after the 6-month follow-up period. After treatment, 24 (25.5%) of the 94 patients reported having prolonged pain. Significant improvements were seen in the PCS, PDAS, and ODI scores in the pain relief group, and in the HADS depression scores in the prolonged pain group. On univariate and multiple regression analysis, HADS depression scores were identified as a factor related to prolonged pain after treatment.
Conclusions: The results of the present study suggest that severe depression at the initial visit to the liaison outpatient clinic was an exacerbating factor for prolonged pain after treatment. (C) 2017 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jos.2017.01.004

関節リウマチ患者の前足部変形に対する切除関節形成術と関節温存手術の治療成績の比較

Sauve-Kapandji法術後掌屈可動域減少例の検討

竹下歩, 西田圭一郎, 島村安則, 那須義久, 尾崎敏文

日本手外科学会雑誌 34 ( 1 ) S415 - S415 2017年4月

RAにおける手関節形成術の検討

竹下歩, 西田圭一郎, 那須義久, 中原龍一, 町田崇博, 堀田昌宏, 兼田大輔, 尾崎敏文

岡山医学会雑誌 129 ( 1 ) 65 - 65 2017年4月

堀田昌宏, 雑賀建多, 竹下歩, 兼田大輔, 大橋秀基, 尾崎敏文, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一

中国・四国整形外科学会雑誌 29 ( 1 ) 157 - 157 2017年4月

Denosumab and alendronate treatment in patients with back pain due to fresh osteoporotic vertebral fractures 査読

Tomoko Tetsunaga, Tomonori Tetsunaga, Keiichiro Nishida, Masato Tanaka, Yoshihisa Sugimoto, Tomoyuki Takigawa, Yoshitaka Takei, Toshifumi Ozaki

JOURNAL OF ORTHOPAEDIC SCIENCE 22 ( 2 ) 230 - 236 2017年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Introduction: Denosumab specifically inhibits the receptor activator for nuclear factor-kappa B ligand (RANKL), and prevents osteoporotic fractures. Several reports have analyzed the effects of denosumab and alendronate alone on bone mineral density (BMD) or reduction of fracture risk. The objective of this study was to analyze the effects of antiresorptive osteoporosis pharmacotherapy on pain relief in patients with fresh vertebral fracture.
Methods: This retrospective, single-center study included 80 patients (10 males, 70 females) with fresh osteoporotic vertebral fractures treated using denosumab at a dose of 60 mg subcutaneously every 6 months (40 patients) or alendronate at a dose of 35 mg orally every week (40 patients) for 6 months in our hospital. The mean age of subjects was 77 years (range, 55-92 years). The primary outcome was duration of back pain. Secondary outcomes included changes in BMD, serum type 1 collagen cross-linked N-telopeptide (NTX), and serum N-terminal propeptide of type 1 collagen (P1NP) from baseline to 6 months. Pain catastrophizing due to back pain was assessed using the Pain Catastrophizing Scale (PCS). The incidences of further vertebral fracture and adverse events were also assessed.
Results: Pain relief was obtained at a mean of 3.3 weeks with denosumab and 5.4 weeks with alendronate. Pain relief was achieved significantly earlier with denosumab than with alendronate. At 6 months, change in BMD was higher with denosumab (6.1%) than with alendronate (0.8%). No significant differences in changes in NTX and P1NP were observed between groups. Scores for PCS were significantly lower for denosumab than for alendronate. The incidence of further vertebral fractures was 5% with denosumab and 10% with alendronate. Adverse event rates were similar between groups.
Conclusions: Denosumab enabled earlier pain relief than alendronate and avoided catastrophizing in patients with osteoporotic vertebral fractures after 6 months of treatment. (C) 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jos.2016.11.017

関節リウマチ中後足部変形に対する選択的固定術の短・中期成績

リウマチ性疾患に合併する感染症の対策と克服手術部位感染症とDMARDsの管理

那須義久, 中原龍一, 西田圭一郎, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 246 - 246 2017年3月

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 堀田昌宏, 竹下歩, 兼田大輔, 尾崎敏文

日本整形外科学会雑誌 91 ( 3 ) S863 - S863 2017年3月

SAFE-Qを用いた関節リウマチ足部手術成績の評価

兼田大輔, 西田圭一郎, 那須義久, 中原龍一, 雑賀建多, 堀田昌宏, 竹下歩, 大橋秀基, 尾崎敏文

日本整形外科学会雑誌 91 ( 3 ) S863 - S863 2017年3月

関節リウマチ患者の前足部変形に対する切除関節形成術と関節温存手術の治療成績

堀田昌宏, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 雑賀建多, 竹下歩, 兼田大輔, 大橋秀基, 尾崎敏文

日本整形外科学会雑誌 91 ( 3 ) S860 - S860 2017年3月

関節リウマチ患者における足部障害の評価

吉村将秀, 雑賀建多, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌宏, 中原龍一, 那須義久, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 91 ( 3 ) S845 - S845 2017年3月

関節リウマチの罹病期間・疾患活動性と関節破壊 modified Total Sharp ScoreとARASHI scoreの比較検討

那須義久, 橋詰謙三, 大橋秀基, 兼田大輔, 竹下歩, 堀田昌弘, 中原龍一, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 91 ( 3 ) S712 - S712 2017年3月

QOL向上を目指したRA薬物療法と手術療法の融合リウマチ患者のbody imageに対する手術治療の影響

西田圭一郎, 堀田昌宏, 那須義久, 中原龍一, 大橋秀基, 竹下歩, 兼田大輔, 沖田駿治, 尾崎敏文

日本整形外科学会雑誌 91 ( 2 ) S415 - S415 2017年3月

トファシチニブ投与中に行った整形外科手術の周術期経過

竹下歩, 西田圭一郎, 那須義久, 中原龍一, 堀田昌宏, 兼田大輔, 大橋秀基, 沖田駿治, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 641 - 641 2017年3月

リウマチ性疾患の画像深層学習を用いた関節リウマチ患者単純X線写真の骨びらん解析教師データの最適化

中原龍一, 西田圭一郎, 那須義久, 堀田昌宏, 竹下歩, 兼田大輔, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 579 - 579 2017年3月

RAの手術上肢 Patient-related elbow evaluation(PREE)によるRA人工肘関節置換術の臨床評価

原田遼三, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 堀田昌宏, 竹下歩, 兼田大輔, 大橋秀基, 沖田駿治, 棗田将光, 山下美鈴, 高杉幸司, 斎藤大輔, 江澤和彦, 藤田慎一朗, 竹本美由紀, 山本渉

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 539 - 539 2017年3月

RAの手術上肢 50歳未満の比較的若年者に行った人工肘関節全置換術の臨床成績の検討

沖田駿治, 西田圭一郎, 那須義久, 中原龍一, 堀田昌宏, 竹下歩, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 538 - 538 2017年3月

膠原病と妊娠関節リウマチ(RA)の手術が患者のボディイメージ(BI)に与える影響

小橋靖子, 西田圭一郎, 堀田昌宏, 那須義久, 橋詰謙三, 中原龍一, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 521 - 521 2017年3月

RAの手術下肢 RA前足部手術における術式選択と治療成績の検討

兼田大輔, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 原田遼三, 町田崇博, 堀田昌宏, 竹下歩, 大橋秀基, 沖田駿治, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 501 - 501 2017年3月

RAの手術下肢関節リウマチ(RA)患者における足部・足関節手術と抑うつ傾向の関係性

大橋秀基, 西田圭一郎, 那須義久, 中原龍一, 堀田昌宏, 竹下歩, 兼田大輔, 小橋靖子, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 501 - 501 2017年3月

関節リウマチ診療における患者立脚型評価患者立脚型評価からみたRA手術の有用性

堀田昌宏, 西田圭一郎, 小橋靖子, 橋詰謙三, 那須義久, 中原龍一, 町田崇博, 竹下歩, 兼田大輔, 大橋秀基, 尾崎敏文

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 258 - 258 2017年3月

膠原病・リウマチ性疾患の診療ガイドライン関節リウマチ診療ガイドライン JCR2014に基づく一般医向け診療ガイドラインの作成

山中寿, 伊藤宣, 遠藤平仁, 金子祐子, 川人豊, 岸本暢将, 小嶋俊久, 小嶋雅代, 瀬戸洋平, 中山健夫, 西田圭一郎, 平田信太郎, 松下功, 宮坂信之

日本リウマチ学会総会・学術集会プログラム・抄録集 61回 237 - 237 2017年3月

Results of Total Elbow Arthroplasty with Cementless Implantation of an Alumina Ceramic Elbow Prosthesis for Patients with Rheumatoid Arthritis 査読

Keiichiro Nishida, Kenzo Hashizume, Masatsugu Ozawa, Ayumu Takeshita, Daisuke Kaneda, Ryuichi Nakahara, Yoshihisa Nasu, Yasunori Shimamura, Hajime Inoue, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 71 ( 1 ) 41 - 47 2017年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We investigated the long-term clinical results of total elbow arthroplasty (TEA) by cementless fixation of alumina ceramic unlinked elbow prostheses (J-alumina ceramic elbows: JACE) for the reconstruction of elbow joints with rheumatoid arthritis (RA). Seventeen elbows in 17 patients (aged 44-72 years, average 54.8) replaced by JACE TEA without bone cement were investigated. The average follow-up period was 10.7 (range, 1.0-19.3) years. Clinical conditions of each elbow before and after surgery were assessed according to the Mayo Elbow Performance Index (MEPI). Radiographic loosening was defined as a progressive radiolucent line of more than 1 mm that was completely circumferential around the intramedullary stem. The average MEPI significantly improved from 46.8 points preoperatively to 66.8 points at final follow-up (p= 0.0226). However, aseptic loosening was noted in 10 of 17 elbows (58.8%) and revision surgery was required in 7 (41.2%). Most loosening was observed on the humeral side. With radiographic loosening and revision surgery defined as the end points, the likelihoods of prosthesis survival were 41.2% and 51.8%, respectively, up to 15 years by Kaplan-Meier analysis. The clinical results of JACE implantation without bone cement were disappointing, with high revision and loosening rates of the humeral component.

人工指関節置換術とそのリハビリテーション

那須義久, 坂口和輝, 西田圭一郎

The Japanese journal of rehabilitation medicine = リハビリテーション医学 54 ( 3 ) 191 - 194 2017年

記述言語：日本語出版者・発行元：公益社団法人日本リハビリテーション医学会

人工指関節置換術は，股関節や膝関節などと比べて経験することの少ない手術であり，関節リウマチ（RA）の手指変形に対して行われる症例が大きな割合を占める．強力な抗リウマチ薬の普及によりRA症例の人工関節手術が世界的に減少傾向にある中，本邦では手指の小手術がむしろ増加傾向にあり，より高い機能・整容的目標の達成が求められるようになっている．人工関節の特性や，軟部組織の破綻のメカニズムと再建方法について熟知することが人工関節置換術を正確に行うためには必須であり，リハビリテーションを担当するスタッフとの情報を共有する必要がある．本稿では最も多く行われているRAの中手指節関節（MCP関節）変形に対する人工関節置換術を例に，手術とリハビリテーションの実際について概説する．

DOI： 10.2490/jjrmc.54.191

その他リンク： http://search.jamas.or.jp/link/ui/2017296065

Safety and effectiveness of certolizumab pegol in patients with rheumatoid arthritis: Interim analysis of post-marketing surveillance 査読

Hideto Kameda, Keiichiro Nishida, Toshihiro Nannki, Akira Watanabe, Yukiya Oshima, Shigaki Momohara

Japanese Journal of Clinical Immunology 40 ( 3 ) 196 - 205 2017年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Society for Clinical Immunology

Objective: To evaluate the safety and effectiveness of certolizumab pegol (CZP) in a real-world setting among Japanese patients with rheumatoid arthritis. Methods: Post-marketing surveillance data from 2,579 patients treated with CZP were analyzed. Adverse events (AEs) observed during the 24-week CZP treatment period were recorded. Disease activity was evaluated using DAS28-ESR and DAS28-CRP at baseline, Week 12, Week 24, or at withdrawal. Results: The total period of exposure to CZP was 1313.8 patient-years (PY). AEs were reported in 658 (25.5%) patients, at an event rate (ER) of 73.68/100 PY. The most frequent serious AEs were pneumonia, herpes zoster, and interstitial lung disease, at ER per 100 PY of 2.06, 1.29, and 1.22, respectively. Mean disease activity scores at baseline, as measured by DAS28-ESR and DAS28-CRP, were 4.77 ± 1.34 and 4.21 ± 1.27, respectively. Mean changes from baseline at the last observation were –1.29 ± 1.46 and –1.30 ± 1.42, respectively. EULAR good or moderate responses were achieved in 65% of patients. Longer disease duration, prior biologics use, and treatment without MTX co-therapy were associated with EULAR no response. Conclusion: In this interim analysis, no new safety signals were observed. Clinical response to CZP was observed in approximately two thirds of patients.

DOI： 10.2177/jsci.40.196

Discrimination between malignant and benign vertebral fractures using magnetic resonance imaging 国際誌

Tomoyuki Takigawa, Masato Tanaka, Yoshihisa Sugimoto, Tomoko Tetsunaga, Keiichiro Nishida, Toshifumi Ozaki

Asian Spine Journal 11 ( 3 ) 478 - 483 2017年

小児上腕骨顆上骨折後にVolkmann拘縮を来した1例

柏原尚子, 島村安則, 原田遼三, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

日本小児整形外科学会雑誌 25 ( 2 ) 183 - 187 2016年12月

記述言語：日本語出版者・発行元：(一社)日本小児整形外科学会

小児上腕骨顆上骨折は、小児肘関節周囲骨折の中で最も高頻度に発生し、合併症が多い疾患である。上腕骨顆上骨折後にVolkmann拘縮を来した1例を経験したので報告する。7歳男児、ジャングルジムより墜落して受傷。前医で上腕骨顆上骨折と診断され、当日創外固定術を施行された。術後徐々に手指の屈曲傾向が進行し、当科紹介となった。Volkmann拘縮と診断し、装具加療や徹底したリハビリの後、屈筋腱解離術を施行した。手術所見としては、屈筋群深層筋線維に変性像を認め、正中・尺骨神経剥離術、屈筋群剥離・前進術を施行した。術後6ヵ月時、DIP関節の屈曲拘縮が残存するも全指伸展位保持可能となり、術後7年時生活に支障のない状態まで回復した。小児上腕骨顆上骨折の合併症であるVolkmann拘縮は、重篤な後遺症を残す。本骨折に対していかなる治療方法を選択しても、阻血性障害への注意が重要である。(著者抄録)

【初期研修医・後期研修医のための必修整形外科】各種検査法超音波検査

中原龍一, 西田圭一郎

関節外科 35 ( 10月増刊 ) 71 - 77 2016年10月

痛みリエゾン外来における慢性疼痛患者の痛みと動作能力の関係

太田晴之, 岩井賢司, 野澤康明, 築山尚司, 堅山佳美, 千田益生, 西田圭一郎, 鉄永倫子, 佐々木賢太郎, 西江宏行

理学療法学 43 ( Suppl.2 ) P - 3 2016年10月

変形性関節症における骨棘形成に対するADAM12の関与

堀田昌宏, 西田圭一郎, 古松毅之, 宮澤慎一, 那須義久, 中原龍一, 藤原智洋, 町田崇博, 竹下歩, 兼田大輔, 前原亜美, 櫻井美和, 国定俊之, 尾崎敏文

日本整形外科学会雑誌 90 ( 8 ) S1590 - S1590 2016年8月

RA手指変形の治療関節リウマチのボタン穴変形・スワンネック変形に対する再建術

西田圭一郎, 中原龍一, 那須義久, 島村安則, 尾崎敏文

日本手外科学会雑誌 33 ( 1 ) S19 - S19 2016年4月

岡山大学病院における難治性慢性痛に対する集学的治療の検討

鉄永倫子, 西田圭一郎, 鉄永智紀, 尾崎敏文, 西江宏行, 太田晴之, 井上真一郎, 小田幸治, 龍野耕一, 宮脇卓也, 神崎浩孝

日本整形外科学会雑誌 90 ( 2 ) S39 - S39 2016年3月

Consensus-based identification of factors related to false-positives in ultrasound scanning of synovitis and tenosynovitis 査読

Kei Ikeda, Akihiro Narita, Michihiro Ogasawara, Shigeru Ohno, Yutaka Kawahito, Atsushi Kawakami, Hiromu Ito, Isao Matsushita, Takeshi Suzuki, Kenta Misaki, Takehisa Ogura, Tamotsu Kamishima, Yohei Seto, Ryuichi Nakahara, Atsushi Kaneko, Takayuki Nakamura, Mihoko Henmi, Jun Fukae, Keiichiro Nishida, Takayuki Sumida, Takao Koike

MODERN RHEUMATOLOGY 26 ( 1 ) 9 - 14 2016年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Introduction: We aimed to identify causes of false-positives in ultrasound scanning of synovial/tenosynovial/bursal inflammation and provide corresponding imaging examples.Methods: We first performed systematic literature review to identify previously reported causes of false-positives. We next determined causes of false-positives and corresponding example images for educational material through Delphi exercises and discussion by 15 experts who were an instructor and/or a lecturer in the 2013 advanced course for musculoskeletal ultrasound organized by Japan College of Rheumatology Committee for the Standardization of Musculoskeletal Ultrasonography.Results: Systematic literature review identified 11 articles relevant to sonographic false-positives of synovial/tenosynovial inflammation. Based on these studies, 21 candidate causes of false-positives were identified in the consensus meeting. Of these items, 11 achieved a predefined consensus (80%) in Delphi exercise and were classified as follows: (I) Gray-scale assessment [(A) non-specific synovial findings and (B) normal anatomical structures which can mimic synovial lesions due to either their low echogenicity or anisotropy]; (II) Doppler assessment [(A) Intra-articular normal vessels and (B) reverberation)]. Twenty-four corresponding examples with 49 still and 23 video images also achieved consensus.Conclusions: Our study provides a set of representative images that can help sonographers to understand false-positives in ultrasound scanning of synovitis and tenosynovitis.

DOI： 10.3109/14397595.2015.1091123

Clinical and radiographic study of partial arthrodesis for rheumatoid wrists 国際誌

Saito T, Nishida K, Hashizume K, Nakahara R, Harada R, Machida T, Horita M, Ozaki T

Mod Rheumatol 26 ( 1 ) 57 - 61 2016年

Shortening Oblique Osteotomy with Screw Fixation for Correction of the Lesser Metatarsophalangeal Joints of Rheumatoid Forefoot

Nishida K, Machida T, Horita M, Hashizume K, Nakahara R, Nasu Y, Ohashi H, Saiga K, Ozaki T

Acta Med Okayama 70 ( 6 ) 477 - 483 2016年

Risk factors for surgical site infection and delayed wound healing after orthopedic surgery in rheumatoid arthritis patients 国際誌

Kadota Y, Nishida K, Hashizume K, Nasu Y, Nakahara R, Kanazawa T, Ozawa M, Harada R, Machida T, Ozaki T

Mod Rheumatol 26 ( 1 ) 68 - 74 2016年

Effect of Tramadol/Acetaminophen on Motivation in Patients with Chronic Low Back Pain 国際誌

Tetsunaga T, Tetsunaga T, Tanaka M, Nishida K, Takei Y, Ozaki T

Pain Res Manag 2016 7458534 - 7458534 2016年

The process of collecting and evaluating evidences for the development of Guidelines for the management of rheumatoid arthritis, Japan College of Rheumatology 2014: Utilization of GRADE approach. 査読国際誌

Masayo Kojima, Takeo Nakayama, Yutaka Kawahito, Yuko Kaneko, Mitsumasa Kishimoto, Shintaro Hirata, Yohei Seto, Hirahito Endo, Hiromu Ito, Toshihisa Kojima, Keiichiro Nishida, Isao Matsushita, Kiichiro Tsutani, Ataru Igarashi, Naoyuki Kamatani, Mieko Hasegawa, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern rheumatology 26 ( 2 ) 175 - 9 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To describe the process of collecting and evaluating evidence for treating rheumatoid arthritis (RA) for developing clinical practice guidelines (CPGs) for rheumatologists in Japan. METHODS: The task force comprised rheumatologists, epidemiologists, health economists, and patients. First, the critical outcomes were determined according to a three-round Delphi method, and eight topics with 88 clinical questions (CQs) were formulated. A systematic review of CQs was conducted using the Cochran Database of Systematic Reviews, MEDLINE, and Japana Centra Revvo Medicina (2003-2012). A questionnaire survey and focus group interview were performed to capture the patients' values and preferences. Data from the National Health Insurance drug price list and product information provided by pharmaceutical companies were collected to evaluate drug cost and safety. The GRADE approach was used to describe the evidence quality and determine the strength of recommendations. Recommendations were developed using a modified Delphi method by a multidisciplinary panel including patients. RESULTS: Eight meetings and frequent e-mail communications were conducted to draft a quality assessment of evidence and recommendations. For 88 CQs, recommendation statements were determined. CONCLUSIONS: Using the GRADE approach, new CPGs successfully addressed important clinical issues for treating RA patients. Timely updating of recommendations should be routinely considered.

DOI： 10.3109/14397595.2015.1069474

痛みリエゾン外来における慢性疼痛患者の痛みと動作能力の関係

太田晴之, 岩井賢司, 野澤康明, 築山尚司, 堅山佳美, 千田益生, 西田圭一郎, 鉄永倫子, 佐々木賢太郎, 西江宏行

理学療法学Supplement 2015 309 - 309 2016年

記述言語：日本語出版者・発行元：公益社団法人日本理学療法士協会

【はじめに】2012年4月より慢性疼痛患者に対し，痛みリエゾン外来（開始時は麻酔科リエゾン外来）を開始した。チームは麻酔科医，整形外科医，精神科医，理学療法士，看護師，臨床心理士，薬剤師で構成されている。条件として問診票の記入ができるもの，各医療者側の検査測定が可能なものとした。6ヵ月を治療期間とし，初診時，1ヵ月目，3ヵ月目，終了時の6ヵ月目で定期的な検査測定から評価を実施している。【目的】理学療法を施行した前後の変化，痛みと動作能力の関係を比較検討する。【対象と方法】対象は他院にて身体的・精神的に治療困難とされた慢性疼痛患者136名のうち，理学療法にて6ヵ月間経過が追えた，50例（55.7±15.3歳，男性20名・女性30名）とした。主な疾患の内訳は脊柱管狭窄症12例，頸椎症9例，変形性脊椎症6例，腰椎椎間板ヘルニア4例，筋筋膜性腰痛2例，繊維筋痛症2例，その他15例であった。症候は腰痛15例，全身痛11例，下肢痛7例，頭頸部痛3例，坐骨神経痛4名，その他10名であった。理学療法前後の測定項目はTimed up ＆ go test（以下，TUG），Finger Floor Distance（以下，FFD），片脚立位時間とし，痛みの測定はNumeric Rating Scale（以下，NRS）にて施行し，最も痛みの強い時期のNRSを使用した。検討項目はTUG，FFD，片脚立位時間に対し①初診時のPT施行前後の比較，②6ヵ月時のPT施行前後を比較，③初診時PT施行前と6ヵ月時のPT施行後の比較はWilcoxon符号付順位和検定ならびに，④初診時PT開始前TUG，FFD，片脚立位時間とNRSの関係性，⑤6ヵ月時PT施行後TUG，FFD，片脚立位時間とNRSの関係性についてはピアソンの積率相関係数を用い，5％水準にて統計学的検討を行った。【結果】初回時の理学療法施行した前後では，FFDのみ16.7±17.1cmと12.1±15.5cmであり施行前後で有意差（p＜0.05）が認められた。6ヵ月時の理学療法施行した前後ではTUG10.0±5.7秒と9.4±5.1秒，FFDは11.6±13.4cmと7.1±9.6cm，左片脚立位時間では27.9±19.6秒と30.2±19.7秒施行前後で有意差（p＜0.05）があった。初回時の理学療法施行前と6ヵ月時のPT施行後の比較ではTUG，FFD，左片脚立位時間で有意差（p＜0.01）が認められ，右片脚立位時間では有意差は無かった。初診時TUG，FFD，片脚立位時間とNRSの関係性では，TUGとNRS間に弱いながら相関関係（r=0.33，p＜0.05）を認めた。また6ヵ月時TUG，FFD，片脚立位時間とNRSの相関関係は，初診時と同様にTUGとNRS間に弱いながらも相関関係（r=0.42，p＜0.05）を認めた。【結論】痛みリエゾン外来が6ヶ月間継続可能な症例では理学療法に対し，施行直後より良好な反応を示す患者が多く，初回時と6ヶ月時では明らかな改善がみられた。またNRSとTUGに弱いながらも相関関係を認め，PT開始時よりも6ヵ月時に相関関係が強くなる傾向がみられた。慢性疼痛患者の痛みの改善度と動作能力をみる指標として，TUGが利用できることが示唆された。

DOI： 10.14900/cjpt.2015.0309

Recent advances in upper extremity surgery for rheumatoid arthritis

Nishida, K.

Nihon rinsho. Japanese journal of clinical medicine 74 ( 6 ) 2016年

滑膜細胞におけるA to I microRNA editingによる機能調節の解明

田中陽子, 高田修治, 飯笹久, Artemis Hatzigeorgiou, 宮澤慎一, 古松毅之, 西田圭一郎, 浅原弘嗣

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 88回・38回 [3T特 - 03(3P1127)] 2015年12月

岡山大学病院における難治性慢性痛に対する薬剤師の介入意義について

神崎浩孝, 北村佳久, 千堂年昭, 鉄永倫子, 鉄永智紀, 尾崎敏文, 西江宏行, 太田晴之, 井上真一郎, 小田幸治, 流王雄太, 宮脇卓也, 西田圭一郎

Journal of Musculoskeletal Pain Research 7 ( 3 ) S71 - S71 2015年11月

メカニカルストレスに対するJAK阻害薬tofacitinibの軟骨破壊抑制効果

町田崇博, 西田圭一郎, 中原龍一, 那須義久, 斎藤太一, 堀田昌宏, 竹下歩, 兼田大輔, 尾崎敏文

日本整形外科学会雑誌 89 ( 8 ) S1718 - S1718 2015年9月

Postoperative complications in patients with rheumatoid arthritis using a biological agent - A systematic review and meta-analysis. 査読国際誌

Hiromu Ito, Masayo Kojima, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Takeo Nakayama, Hirahito Endo, Shintaro Hirata, Yuko Kaneko, Yutaka Kawahito, Mitsumasa Kishimoto, Yohei Seto, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka, Hisashi Yamanaka

Modern rheumatology 25 ( 5 ) 672 - 8 2015年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: To evaluate, through a systematic review of the literature, the association between the use of biological disease-modifying antirheumatic drugs (bDMARDs) and surgical site infection (SSI) or wound healing delay after orthopedic surgery in patients with rheumatoid arthritis (RA). METHODS: A systematic review of articles indexed in the Cochrane Library, PubMed, and Web of Science from 1992 to 2012 was performed. The search aimed to identify studies describing SSI or wound healing delay in patients with RA treated with or without bDMARDs. Articles fulfilling the predefined inclusion criteria were reviewed systematically and their quality was appraised. RESULTS: There was no Cochrane review on this subject. We found 75 articles through specific searches of PubMed and Web of Science, and hand searching. After inclusion and exclusion by full-text review, 10 articles were found for SSI, and 5 articles for delayed wound healing. The use of bDMARDs appeared to increase the rate of SSI slightly, especially in large joint-replacement surgery. Delayed wound healing was not increased by the use of bDMARDs. However, the definitions of SSI and delayed wound healing varied between the reviewed articles. Most of the articles focused on tumor necrosis factor-α inhibitors. CONCLUSION: bDMARDs slightly increase the relative risk of SSI but not that of delayed wound healing after orthopedic surgery and should be used with appropriate caution.

DOI： 10.3109/14397595.2015.1014302

キーンベック病に対する手術治療長期経過の1例

原田遼三, 島村安則, 井上円加, 小澤正嗣, 山川泰明, 柏原尚子, 雑賀建多, 魚谷弘二, 中原龍一, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 27 ( 2 ) 379 - 379 2015年9月

健常人の横隔神経伝導検査における左右差の検討

堅山佳美, 千田益生, 原田遼三, 上原健敬, 西田圭一郎, 尾崎敏文

The Japanese Journal of Rehabilitation Medicine 52 ( Suppl. ) S198 - S198 2015年5月

Hyaluronan suppresses mechanical stress-induced expression of catabolic enzymes by human chondrocytes via inhibition of IL-1 beta production and subsequent NF-kappa B activation 査読

Masatsugu Ozawa, Keiichiro Nishida, Aki Yoshida, Taichi Saito, Ryozo Harada, Takahiro Machida, Toshifumi Ozaki

INFLAMMATION RESEARCH 64 ( 3-4 ) 243 - 252 2015年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER BASEL AG

To investigate the inhibitory effect of hyaluronan (HA) on mechanical stress- induced expression of a disintegrin and metalloproteinase with thrombospondin type1 motifs (ADAMTS)-4, -5 and matrix metalloproteinase (MMP)-13 by human chondrocytes.
Normal human articular chondrocytes were pre-incubated with or without 1.0 mg/mL HA (2700 kDa) for 12 h at 37 A degrees C in stretch chambers, then they were exposed to uni-axial cyclic tensile strain (CTS, 0.5 Hz, 10 % elongation). The expression of ADAMTS-4, -5, and MMP-13 were analyzed by real-time polymerase chain reaction and Immunocytochemistry. The concentration of IL-1 beta in the supernatant was measured using enzyme-linked immunosorbent assay (ELISA). The nuclear translocation of runt-related transcription factor 2 (RUNX-2) and nuclear factor-kappa B (NF-kappa B) was examined by ELISA and immunocytochemistry, and phosphorylation of NF-kappa B was examined by western blotting.
HA inhibited mRNA expression of ADAMTS-4, -5, and MMP13 after 24 h CTS via inhibition of IL-1 beta secretion and NF-kappa B activation. However, HA failed to inhibit CTS-induced RUNX-2 expression and subsequent expression of ADAMTS-5 and MMP-13 1 h after CTS.
Our results demonstrated that HA significantly suppressed mechanical stress-induced expression of catabolic proteases by inhibition of the NF-kappa B-IL-1 beta pathway, but did not suppress mechanical stress-induced RUNX-2 signaling.

DOI： 10.1007/s00011-015-0804-2

関節リウマチ患者におけるARASHIスコアを用いた大関節破壊評価

元村拓, 松下功, 金子敦史, 神戸克明, 荒井勝光, 久我芳昭, 阿部麻美, 松本雄, 中川夏子, 西田圭一郎, 木村友厚

日本整形外科学会雑誌 89 ( 3 ) S568 - S568 2015年3月

MRI of Rheumatoid Arthritis: Comparing the Outcome Measures in Rheumatology Clinical Trials (OMERACT) Scoring and Volume of Synovitis for the Assessment of Biologic Therapy 査読

Ryuichi Nakahara, Keiichiro Nishida, Kenzo Hashizume, Ryouzou Harada, Takahiro Machida, Masahiro Horita, Aiji Ohtsuka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 69 ( 1 ) 29 - 35 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The outcome measures in rheumatology clinical trials (OMERACT) scores are the most mature quantitation system for rheumatoid arthritis (RA) on magnetic resonance imaging (MRI). Direct measuring techniques of synovial volume have been reported with good reproducibility, although few reports have demonstrated the changes of these measures in response to treatment. To assess these clinical responses, we evaluated the correlation of the changes of clinical activity score 28-joints disease activity score (DAS28-CRP) with the changes of OMERACT scores and with synovial volume measurements. Eight RA patients who were treated by biologic agents were examined with MRI of the dominant affected wrist and finger joints before and one year after the treatment. The total OMERACT score was reduced from 48.0 to 41.3, and synovial volume was reduced from 15.4 to 8.8 milliliters. Positive correlations were seen between the changes of DAS28-CRP and the changes of OMERACT synovitis score (r = 0.27), OMERACT total score (r = 0.43) and synovial volume (r = 0.30). Limited to synovium assessment, synovial volume showed a better correlation with DAS28-CRP than the OMERACT synovitis score. On the other hand, the OMERACT total score showed a higher correlation with DAS28-CRP than synovial volume, probably because the OMERACT total score includes scores for bone erosion and bone edema as well.

Tocilizumab, a humanized anti-IL-6R antibody, as an emerging therapeutic option for rheumatoid arthritis: Molecular and cellular mechanistic insights

Hashizume, M., Tan, S.-L., Takano, J., Ohsawa, K., Hasada, I., Hanasaki, A., Ito, I., Mihara, M., Nishida, K.

International Reviews of Immunology 34 ( 3 ) 2015年

Analysis of Musculoskeletal Systems and Their Diseases. Pathology and treatment for injuries of the tendon and ligament

Furumatsu, T., Shimamura, Y., Nishida, K.

Clinical calcium 25 ( 8 ) 2015年

Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice

Mukai, T., Gallant, R., Ishida, S., Kittaka, M., Yoshitaka, T., Fox, D.A., Morita, Y., Nishida, K., Rottapel, R., Ueki, Y.

Arthritis and Rheumatology 67 ( 3 ) 2015年

関節リウマチ(RA)に対するSwansonとAVANTAによるMP人工指関節置換術の治療成績

原田遼三, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 尾崎敏文, 西田圭一郎

日本関節病学会誌 33 ( 2 ) 175 - 182 2014年7月

記述言語：日本語出版者・発行元：(一社)日本関節病学会

関節リウマチに対しSwansonおよびAVANTAインプラントを用いてMP人工指関節置換術を行い、半年以上経過観察し得た34例118指について治療成績を検討した。Swanson群は48指、AVANTA群は70指であった。治療成績として、MP関節可動域、握力、ピンチ力、health assessment questionnaire、Hand20、Disabilities of the Arm, Shoulder and Handを調査した。また、画像評価として、インプラント周囲の骨透亮像と硬化像を計測し、更に尺側偏位、破損等についても検討を行なった。その結果、術後の臨床成績においてAVANTA群が優れる傾向にあったが、明らかな有意差はなかった。インプラント破損をSwanson群の3指に認めたが、シリコンインプラントの耐久性として経過観察期間(Swanson群60.7±20.5ヵ月、AVANTA群21.3±9.1ヵ月)の影響が考えられた。

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J05177&link_issn=&doc_id=20140813110010&doc_link_id=%2Ffd8kanse%2F2014%2F003302%2F011%2F0175-0182%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffd8kanse%2F2014%2F003302%2F011%2F0175-0182%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Short-term results of the PROSNAP linked elbow prosthesis with a snap-in structure and modular flange for the reconstruction of severely damaged rheumatoid elbows. 国際誌

Keiichiro Nishida, Kenzo Hashizume, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Takahiro Machida, Yoshihisa Nasu, Toshihumi Ozaki, Hajime Inoue

Journal of shoulder and elbow surgery 23 ( 6 ) 837 - 42 2014年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: We aimed to evaluate the early clinical results of the reconstruction of problematic elbow joints due to rheumatoid arthritis (RA) using a PROSNAP linked elbow prosthesis (Kyocera Medical, Osaka, Japan) for total elbow arthroplasty. METHODS: Seventeen elbows in 14 RA patients were replaced with a PROSNAP elbow with cement fixation. The patients comprised 1 man and 13 women, with a mean age of 63.9 years (range, 52-83 years) at the time of surgery. The preoperative conditions of the elbows were arthritis mutilans (n = 10), an ankylosed or stiff elbow with a preoperative range of motion of 45° or less (n = 4), and loosening of a primary total elbow arthroplasty (n = 3). The mean follow-up period was 47.7 months (range, 32-69 months), with a 100% follow-up rate. The clinical outcome of the elbows was evaluated by the Mayo Elbow Performance Index (maximum, 100 points). RESULTS: The mean postoperative Mayo Elbow Performance Index score improved from 57.6 points to 97.1 points. Preoperatively, 3 of the 17 elbows were judged as good, 7 as fair, and 7 as poor; at final follow-up, 16 elbows were judged as excellent and 1 as good. Complications were noted in 1 elbow (6%), which had undergone a postoperative fracture. CONCLUSIONS: The PROSNAP elbow prosthesis can be safely implanted through a relatively easy procedure and provides satisfactory short-term clinical outcomes for the reconstruction of severely damaged RA elbows. LEVEL OF EVIDENCE: Level IV, case series, treatment study.

DOI： 10.1016/j.jse.2013.12.031

Abatacept management during the perioperative period in patients with rheumatoid arthritis: report on eight orthopaedic procedures. 国際誌

Keiichiro Nishida, Yoshihisa Nasu, Kenzo Hashizume, Ryuichi Nakahara, Masatsugu Ozawa, Ryozo Harada, Takahiro Machida, Toshihumi Ozaki

Modern rheumatology 24 ( 3 ) 544 - 5 2014年5月

タクロリムス使用下の整形外科手術

町田崇博, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文, 那須義久

岡山医学会雑誌 126 ( 1 ) 76 - 77 2014年4月

橈骨遠位部骨折に対するMIPO法による治療成績

島村安則, 野田知之, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 井上円加, 尾崎敏文, 西田圭一郎

中国・四国整形外科学会雑誌 26 ( 1 ) 149 - 149 2014年4月

Ultrasound Assessment of Synovial Pathologic Features in Rheumatoid Arthritis Using Comprehensive Multiplane Images of the Second Metacarpophalangeal Joint 査読

Kei Ikeda, Yohei Seto, Akihiro Narita, Atsushi Kawakami, Yutaka Kawahito, Hiromu Ito, Isao Matsushita, Shigeru Ohno, Keiichiro Nishida, Takeshi Suzuki, Atsushi Kaneko, Michihiro Ogasawara, Jun Fukae, Mihoko Henmi, Takayuki Sumida, Tamotsu Kamishima, Takao Koike

ARTHRITIS & RHEUMATOLOGY 66 ( 3 ) 523 - 532 2014年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL

Objective. The aim of this pilot study was to provide groundwork that could be utilized to optimize the global ultrasound (US) assessment of the whole joint for synovial pathologic features in patients with rheumatoid arthritis (RA).
Methods. US images of the second metacarpophalangeal joint in 8 predefined imaging planes, comprising regions that comprehensively capture the synovial pathologic features of the whole joint, were obtained from 30 patients with RA. Twelve experienced sonographers evaluated these images at the level of both the individual image and the whole joint, using a visual analog scale (VAS) to assess pathologic severity. Interrater reproducibility of the VAS scores was evaluated with intraclass correlation coefficients (ICCs), and factors that independently influenced the global assessment of the whole joint were identified using multiple linear regression analysis.
Results. A total of 14,276 VAS scores were analyzed. Interrater reproducibility of any eligible VAS assessment of synovial pathologic features was good (ICC 0.65). US assessment of synovial pathologic features in joints with mild inflammation was less reproducible than that in joints with severe inflammation. Although the most severely affected region in a joint did not always represent the average pathologic severity among the 8 regions, global assessment of the whole joint strongly correlated with assessment of the most severely affected region (P < 0.001). Importantly, the standard, midline imaging plane was not the most influential plane on the global assessment of the whole joint. Assessment of synovial fluid accumulation was not reproducible (ICCs 0.20-0.42) and did not substantially influence the global assessment of synovial inflammation (beta = 0.06).
Conclusion. The results of this study provide a unique data set that could be utilized to optimize the global US assessment of synovial pathologic features of the whole joint in patients with RA.

DOI： 10.1002/art.38280

【手指の変形性関節症】Hand OAのMRI所見

中原龍一, 西田圭一郎

リウマチ科 51 ( 2 ) 174 - 179 2014年2月

Light and electron microscopic detection of inflammation-targeting liposomes encapsulating high-density colloidal gold in arthritic mice

Ami Maehara, Keiichiro Nishida, Masumi Furutani, Emi Matsumoto, Aiji Ohtsuka, Yoshifumi Ninomiya, Toshitaka Oohashi

INFLAMMATION RESEARCH 63 ( 2 ) 139 - 147 2014年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER BASEL AG

We have previously demonstrated the efficient and time-dependent transvascular localization of Sialyl Lewis X (SLX)-liposomes to inflammatory sites, but the final target of the SLX-liposomes remained uncertain. The aim of this study was to identify the target cells of the liposomes within the inflamed joints of collagen antibody-induced arthritis (CAIA) model mice.SLX-liposomes and unlabeled liposomes encapsulating high-density colloidal gold were administered intravenously into the caudal vein of CAIA mice on day 5 after induction of arthritis when the inflammatory score was maximal (n = 6 per group). Six hours or 24 h after liposome administration, animals were euthanized and hind limbs and ankles were excised without perfusion. After fixation, synovial tissues were examined by light microscopy after silver enhancement of colloidal gold or by transmission electron microscopy.Silver-enhanced signals were detected within the cells around E-selectin-positive blood vessels in the synovium of the SLX-liposome group. These cells were positive for the macrophage/monocyte marker F4/80 or neutrophil marker Ly-6G. Transmission electron microscopy detected the colloidal gold signals together with liposome-like structures within the phagosomes of synovial macrophages. Transmission electron microscopy and energy dispersive X-ray spectrometry could determine gold elements in the lysosomes of synovial macrophages.The results of the current study demonstrate that SLX-liposomes primarily targeting E-selectin in activated endothelial cells could potentially deliver their contents into inflammatory cells around synovial blood vessels in arthritic joints.

DOI： 10.1007/s00011-013-0682-4

A 5-22-year follow-up study of stemmed alumina ceramic total elbow arthroplasties with cement fixation for patients with rheumatoid arthritis 査読

Keiichiro Nishida, Kenzo Hashizume, Yoshihisa Nasu, Makoto Kishimoto, Toshifumi Ozaki, Hajime Inoue

JOURNAL OF ORTHOPAEDIC SCIENCE 19 ( 1 ) 55 - 63 2014年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

We determined mid to long-term results of total elbow arthroplasty (TEA) by use of unlinked elbow prostheses with solid alumina ceramic trochleae, and ceramic ulnar stems (stemmed Kyocera type I; SKC-I) for patients with rheumatoid arthritis.
Fifty-four elbows of 39 patients were available for detailed clinical and radiographic review after a follow-up period of at least 5 years. The mean follow-up period was 12.6 years (range 5-22 years). Clinical condition before and after surgery was assessed by use of a modified version of the Mayo Elbow Performance Score (MEPS; 0-100 points) and a Japan Orthopaedic Association Elbow score (JOA score; 0-100 points). The radiographs were reviewed and loosening was defined as a progressive radiolucent line > 1 mm wide that was completely circumferential around the prosthesis. Clinical records of post-operative events affecting the elbows were used for survival analysis of the prostheses using the Kaplan-Meier method.
The average modified MEPS and JOA scores improved significantly from 39.7 +/- A 14.3 to 44.7 +/- A 9.4, respectively, pre-operatively, to 89.7 +/- A 15.4 and 83.1 +/- A 12.8, respectively, post-operatively (P < 0.0001). The functional assessment score also improved from 4.9 +/- A 2.8 to 8.5 +/- A 3.3 points (P < 0.0001). With loosening or implant revision defined as end points, the likelihood of survival of the prosthesis for up to 20 years was 92.6 % (95 % confidence interval (CI), 85.6-100.0) or 86.3 % (95 % CI 75.0-97.6), respectively.
Satisfactory clinical results were obtained after TEA using SKC-I prostheses, which provided excellent pain relief and functional range of motion. The results of our study reveal the high reliability over a long period of the cemented SKC-I prosthesis with an alumina ceramic component.

DOI： 10.1007/s00776-013-0492-0

当科における人工肩関節置換術の治療成績の検討

金澤智子, 橋詰謙三, 島村安則, 中原龍一, 斎藤太一, 小澤正嗣, 原田遼三, 尾﨑敏文, 西田圭一郎

日本関節病学会誌 33 ( 4 ) 479 - 485 2014年

記述言語：英語出版者・発行元：日本関節病学会

Objective: To investigate the clinical and radiographic results of total shoulder arthroplasty (TSA) for damaged shoulder joints with osteoarthritis (OA) and rheumatoid arthritis (RA).Patients and Methods: From 1999 to 2012 inclusive, we performed 19 total shoulder arthroplasties in 17 patients. A total of sixteen shoulders, five with OA and 11 with RA, from 15 patients were followed up for more than six months. All patients were female, with an average age of 71 years, and an average follow-up period of three years. Preoperative magnetic resonance imaging showed that the supraspinatus tendon was intact in five shoulders (intact group), and torn or thin in 11 shoulders (damaged group), respectively. Clinical outcomes were assessed using the Japanese Orthopedic Association (JOA) score, Disabilities of the Arm, Shoulder and Hand (DASH) score and range of motion (ROM). Radiographic loosening of the humeral stem and glenoid component was evaluated according to the criteria described by Stewart.Results: The average JOA score improved from 39.9 points preoperatively to 80.3 points at the final follow-up. The average DASH score improved from 70.1 points to 56.0 points. The range of active flexion, abduction and external rotation significantly improved postoperatively. Radiolucent line evaluation around the glenoid component was observed in two shoulders. There was no significant difference in the improvement of the JOA score between the intact group and the damaged group. In both groups, pain relief was experienced postoperatively, but the improvement in ROM consisting of flexion, abduction and external rotation, was significantly greater in the intact group than in the damaged group. The postoperative JOA score showed a strong inverse correlation with the preoperative DASH score.Conclusion: The results of the current study showed satisfactory clinical outcomes of TSA for OA and RA, particularly with the treatment effect of good postoperative pain relief. Clinical outcome may depend on the preoperative status of the rotator cuff and the function of the upper extremity.

DOI： 10.11551/jsjd.33.479

輸血不能のエホバの証人に対する人工股関節置換術の経験

その他リンク： https://jlc.jst.go.jp/DN/JLC/20002300823?from=CiNii

田中孝明, 岡田芳樹, 尾﨑敏文, 藤原一夫, 遠藤裕介, 西田圭一郎

中国・四国整形外科学会雑誌 26 ( 2 ) 255 - 259 2014年

記述言語：日本語出版者・発行元：中国・四国整形外科学会

Jehovah's Witnesses refuse blood transfusions on the basis of their religious belief. We report our experience with total hip arthroplasty without blood transfusion in a Jehovah's Witness. The patient was a 70-year-old woman who had been receiving treatment for rheumatoid arthritis for 34 year and had been taking anti-platelet agents for atrial fibrillation and hypertension. Plain radiographs revealed severe erosions (Larsen Grade 4) in the right hip. We used a cemented femoral component and reamed the acetabulum gently to minimize any bleeding, while performing intraoperative blood-salvaging autotransfusion. We carried out hybrid total hip arthroplasty with a cementless acetabular component and a cemented femoral component. The operation time was 62 minutes, intraoperative blood loss was 50ml, and postoperative blood loss was 90ml. The preoperative hemoglobin level was 9.9g/dl, and the lowest hemoglobin level was 6.8g/dl after surgery. At the final follow-up, the patient was able to walk with a T-shaped walking stick, and her Japanese Orthopaedics Association score (right/left) was 80 points/81 points on. We considered that the use of a cemented femoral component and gentle reaming of the acetabulum were factors that reduced bleeding during total hip arthroplasty.

DOI： 10.11360/jcsoa.26.255

関節リウマチとWaddingtonの後成的遺伝風景

西田圭一郎

臨床リウマチ 26 ( 1 ) 5 - 8 2014年

Light and electron microscopic detection of inflammation-targeting liposomes encapsulating high-density colloidal gold in arthritic mice.

Maehara A, Nishida K, Furutani M, Matsumoto E, Ohtsuka A, Ninomiya Y, Oohashi T

Inflamm Res. 63 ( 2 ) 139 - 147 2014年

SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model

Mukai, T., Gallant, R., Ishida, S., Yoshitaka, T., Kittaka, M., Nishida, K., Fox, D.A., Morita, Y., Ueki, Y.

PLoS ONE 9 ( 8 ) 2014年

Development and validation of a new radiographic scoring system to evaluate bone and cartilage destruction and healing of large joints with rheumatoid arthritis: ARASHI (Assessment of rheumatoid arthritis by scoring of large joint destruction and healing in radiographic imaging) study. 国際誌

Atsushi Kaneko, Isao Matsushita, Katsuaki Kanbe, Katsumitsu Arai, Yoshiaki Kuga, Asami Abe, Takeshi Matsumoto, Natsuko Nakagawa, Keiichiro Nishida

Modern rheumatology 23 ( 6 ) 1053 - 62 2013年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: To assess the reliability and sensitivity of a novel scoring method to evaluate the radiographic appearance of and longitudinal changes including joint remodeling in large joints with early and established rheumatoid arthritis (RA). METHODS: The ARASHI study group devised new radiographic scoring systems (Status score; range 0-16 points, and Change score; range -11 to 12 points) for evaluation of large joints with RA. Radiographs showing anterior/posterior views of large joints (shoulder, elbow, hip, knee, and ankle joints) taken at two time points (mean interval 2.3 years) were collected from 25 patients with established RA (5 patients for each of the 5 joints, 50 films in total), and an additional 5 films of each joint with severe joint destruction were collected from 5 different sets of RA patients. After consensus on the definition of each component and reader training, images were evaluated using the Larsen's grading system and the ARASHI Status and Change score by 9 independent senior orthopedic surgeons. The reliability was estimated by intra-class correlation coefficients (ICCs) and measurement error by 95% confidence intervals of minimum detectable change (MDC95). RESULTS: ARASHI Status score and Change score significantly correlated with Larsen's grade (r = 0.89, P < 0.0001) and follow-up-baseline differences in Larsen's grade (r = 0.83, P < 0.0001), respectively. Inter-reader ICCs were very high for both Status score (0.88, 95% confidence interval [CI], 0.83-0.92, P < 0.001) and Change score (0.92, 95% CI, 0.87-0.96, P < 0.001). Intra-reader ICCs were also very high for both Status score (0.92, 95% CI, 0.71-0.98, P < 0.001) and Change score (0.97, 95% CI, 0.91-0.99, P < 0.001). The MDC95 for inter-reader agreement were 4.18 (25% of maximum obtainable score, MOS) and 4.99 (21% of MOS) for Status score and Change score, respectively. The MDC95 for intra-reader agreement was acceptable with 2.82 (17% of MOS) and 3.02 (13% of MOS) for Status score and Change score, respectively. CONCLUSION: The ARASHI scoring method showed good inter-/intra-reader reliability with high ICCs and acceptable MDC95 with respect to each large joint and the components of both Status and Change scores. The results suggest that the ARASHI scoring method might be useful for the assessment of status, as well as longitudinal monitoring of destruction and remodeling of large joints with RA.

DOI： 10.1007/s10165-012-0823-6

Occult Compression Fracture of Metacarpal Head without Evidence of Avascular Necrosis 査読

Keiichiro Nishida, Hiroyuki Hashizume, Akihiro Matsukawa, Kenzo Hashizume, Yasunori Shimamura, Yasuyaki Torigoe, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 67 ( 5 ) 311 - 317 2013年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We report a case of 4th metacarpal head collapse of a 19-year-old healthy man. MRI revealed T1 low and T2 high regions in the collapsed 4th metacarpal head, as well as in the right 3rd and left 4th metacarpal head. Our initial diagnosis was occult compression fracture due to avascular necrosis, known as Dieterich's disease. However, pathological findings of surgically resected right 4th metacarpal head were compatible with transient osteoporosis and metacarpal head fracture followed by active tissue repair. The autologous osteochondral transplants from costchondral junction survived and maintained their size and shape even at 10-year follow-up.

【早期関節リウマチ治療を考える】関節リウマチにおける画像診断の進歩とその役割核磁気共鳴画像(MRI) MRIの早期診断と疾患活動性評価の有用性、その問題点について

メカニカルストレスに対するヒアルロン酸の軟骨破壊抑制効果の機序の解析

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 齋藤太一, 金澤智子, 原田遼三, 町田崇博, 尾崎敏文

日本関節病学会誌 32 ( 3 ) 380 - 380 2013年10月

中原龍一, 西田圭一郎

Progress in Medicine 33 ( 9 ) 1901 - 1904 2013年9月

メカニカルストレスに対するヒアルロン酸の軟骨破壊抑制効果の機序の解析

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 原田遼三, 町田崇博, 尾崎敏文

日本整形外科学会雑誌 87 ( 8 ) S1321 - S1321 2013年8月

PROSNAP人工肘関節置換術の短期成績

那須義久, 西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

岡山医学会雑誌 125 ( 2 ) 183 - 184 2013年8月

【上肢のリウマチ診断と治療】治療生物学的製剤が与えたリウマチ関節外科手術の変化

那須義久, 西田圭一郎

関節外科 32 ( 4 ) 382 - 388 2013年4月

関節リウマチの評価法を学ぶ(第2回) 関節レントゲン写真の見方と評価法

原田遼三, 西田圭一郎, 中原龍一, 橋詰謙三

Rheumatology Clinical Research 2 ( 1 ) 53 - 57 2013年4月

記述言語：日本語出版者・発行元：(株)先端医学社

関節リウマチ(RA)の診断治療において、単純X線による関節病変の評価はその所見に特徴的なものが多く、また病態を反映していることなどもあり有用なツールとして広く使用されている。しかし、生物学的製剤の導入を契機に早期診断また治療効果、寛解評価のための鋭敏な検査が必須となり、単純X線のlimitationのためMRIや超音波検査など他のmodalityとの併用が提唱されている。早期診断には不向きであるが、網羅的評価に長けること、reproducibleであるなど利点も多いため単純X線の見方や評価法について熟慮しておく必要がある。多種の評価法が報告されており、どの評価法を用いるかについては各検査法の長所短所を考慮し、目的に応じた評価法の選択を検討する必要がある。(著者抄録)

その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J06167&link_issn=&doc_id=20130423530009&doc_link_id=%2Fae6rclid%2F2013%2F000201%2F009%2F0053-0057%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fae6rclid%2F2013%2F000201%2F009%2F0053-0057%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

再発した手関節尺側部痛の1例

金澤智子, 島村安則, 大森敏規, 篠原健介, 原田遼三, 山川泰明, 小澤正嗣, 井上円加, 斉藤太一, 中原龍一, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 25 ( 1 ) 245 - 245 2013年4月

JACE型人工肘関節置換術の中期成績

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 那須義久, 齋藤太一, 金澤智子, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 87 ( 3 ) S818 - S818 2013年3月

関節リウマチ肘に対するPROSNAP型人工肘関節の術後成績

齋藤太一, 西田圭一郎, 橋詰謙三, 中原龍一, 小澤正嗣, 金澤智子, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 87 ( 3 ) S733 - S733 2013年3月

関節リウマチにおける生物学的製剤と各関節に対する手術の役割 Bio使用中関節リウマチ患者に対する肘関節手術の有用性

西田圭一郎, 金澤智子, 中原龍一, 橋詰謙三, 齋藤太一, 小澤正嗣, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 87 ( 2 ) S251 - S251 2013年3月

RAに対するSwansonとAVANTAによるMP人工指関節置換術の治療成績

原田遼三, 西田圭一郎, 橋詰謙三, 中原龍一, 齋藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

日本整形外科学会雑誌 87 ( 2 ) S83 - S83 2013年3月

臨床研究支援のためのスコア入力・自動統計システムの開発

中原龍一, 西田圭一郎, 橋詰謙三, 小澤正嗣, 齋藤太一, 金澤智子, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 87 ( 3 ) S910 - S910 2013年3月

関節リウマチの手術上肢 RAにおけるNalebuff type I(ボタン穴変形)の治療成績

原田遼三, 西田圭一郎, 橋詰謙三, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 57回・22回 403 - 403 2013年3月

骨・軟骨・滑膜細胞伸展装置を用いたメカニカルストレスに対するヒアルロン酸のヒト軟骨破壊抑制効果

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 57回・22回 317 - 317 2013年3月

RAに対するBio製剤使用中の整形外科手術 Bio使用中患者の整形外科手術の適応

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 町田崇博, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 57回・22回 204 - 204 2013年3月

Multiple Regression Analysis for Grading and Prognosis of Cubital Tunnel Syndrome: Assessment of Akahori's Classification 査読

Masutaka Watanabe, Seizaburo Arita, Hiroyuki Hashizume, Mitsugi Honda, Keiichiro Nishida, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 67 ( 1 ) 35 - 44 2013年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The purpose of this study was to quantitatively evaluate Akahori's preoperative classification of cubital tunnel syndrome. We analyzed the results for 57 elbows that were treated by a simple decompression procedure from 1997 to 2004. The relationship between each item of Akahori's preoperative classification and clinical stage was investigated based on the parameter distribution. We evaluated Akahori's classification system using multiple regression analysis, and investigated the association between the stage and treatment results. The usefulness of the regression equation was evaluated by analysis of variance of the expected and observed scores. In the parameter distribution, each item of Akahori's classification was mostly associated with the stage, but it was difficult to judge the severity of palsy. In the mathematical evaluation, the most effective item in determining the stage was sensory conduction velocity. It was demonstrated that the established regression equation was highly reliable (R = 0.922). Akahori's preoperative classification can also be used in postoperative classification, and this classification was correlated with postoperative prognosis. Our results indicate that Akahori's preoperative classification is a suitable system. It is reliable, reproducible and well-correlated with the postoperative prognosis. In addition, the established prediction formula is useful to reduce the diagnostic complexity of Akahori's classification.

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

Saito T., Nishida K., Furumatsu T., Yoshida A., Ozawa M., Ozaki T.

Osteoarthritis and Cartilage 21 ( 1 ) 165 - 174 2013年1月

記述言語：英語出版者・発行元：Elsevier Ltd

Objective: To investigate the inhibitory effects and the regulatory mechanisms of histone deacetylase (HDAC) inhibitors on mechanical stress-induced gene expression of runt-related transcription factor (RUNX)-2 and a disintegrin and metalloproteinase with thrombospondin motif (ADAMTS)-5 in human chondrocytes. Methods: Human chondrocytes were seeded in stretch chambers at a concentration of 5 x 10(4) cells/chamber. Cells were pre-incubated with or without HDAC inhibitors (MS-275 or trichostatin A; TSA) for 12 h, followed by uniaxial cyclic tensile strain (CTS) (0.5 Hz, 10% elongation), which was applied for 30 min using the ST-140-10 system (STREX, Osaka, Japan). Total RNA was extracted and the expression of RUNX-2, ADAMTS-5, matrix metalloproteinase (MMP)-3, and MMP-13 at the mRNA and protein levels were examined by real-time polymerase chain reaction (PCR) and immunocytochemistry, respectively. The activation of diverse mitogen-activated protein kinase (MAPK) pathways with or without HDAC inhibitors during CTS was examined by western blotting. Results: HDAC inhibitors (TSA: 10 nM, MS-275: 100 nM) suppressed CTS-induced expression of RUNX-2, ADAMTS-5, and MMP-3 at both the mRNA and protein levels within 1 h. CTS-induced activation of p38 MAPK (p38), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (INK) MAPKs was downregulated by both HDAC inhibitors. Conclusion: The CTS-induced expression of RUNX-2 and ADAMTS-5 was suppressed by HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes. The results of the current study suggested a novel therapeutic role for HDAC inhibitors against degenerative joint disease such as osteoarthritis.

DOI： 10.1016/j.joca.2012.09.003

Reliability, validity, and responsiveness of the Japanese version of the patient-rated elbow evaluation

Hanyu, T., Watanabe, M., Masatomi, T., Nishida, K., Nakagawa, T., Nishiura, Y., Ohi, H.

Journal of Orthopaedic Science 18 ( 5 ) 2013年

メカニカルストレスによる軟骨基質分解酵素発現に対するヒストン脱アセチル化酵素阻害剤の抑制効果

斎藤太一, 西田圭一郎, 古松毅之, 小澤正嗣, 金澤智子, 原田遼三, 尾崎敏文

移植 47 ( 6 ) 499 - 499 2012年12月

Cyclic tensile strain inhibits interleukin-1 beta and tumor ncerosis factor-alpha-induced aggrecanase in human chondrosarcoma cell line OUMS-27 by stretch-activated channles

Takashi Ohtsuki, Keiichiro Nishida, Satoshi Hirohata, Yoshifumi Ninomiya

GLYCOBIOLOGY 22 ( 11 ) 1582 - 1583 2012年11月

当科における人工肩関節置換術(TSA)の治療成績の検討

金澤智子, 西田圭一郎, 橋詰謙三, 島村安則, 中原龍一, 斉藤太一, 小澤正嗣, 那須義久, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 317 - 317 2012年10月

【運動器疾患の画像診断】超音波診断関節リウマチの超音波画像診断

中原龍一, 西田圭一郎

別冊整形外科 ( 62 ) 175 - 179 2012年10月

関節リウマチの足関節、中後足部変形に対する治療成績

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 371 - 371 2012年10月

RAにおけるSwansonとAvantaによるMP人工指関節置換術の治療成績

原田遼三, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 317 - 317 2012年10月

バイオ製剤使用のストラテジー並びにバイオ製剤無効例への対応と展望 Bio製剤効果不十分例に対する整形外科手術の有効性

西田圭一郎, 金澤智子, 中原龍一, 橋詰謙三, 斎藤太一, 小澤正嗣, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 259 - 259 2012年10月

Dual Energy CTを用いた骨抽出性能の向上

中原龍一, 西田圭一郎, 金澤智子, 原田遼三, 小澤正嗣, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 243 - 243 2012年10月

人工関節再置換術原因と成否のポイント<パート1.肘 TEA> 岡山大式人工肘関節再置換術例の検討

西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本関節病学会誌 31 ( 3 ) 314 - 314 2012年10月

Radiographic remodeling of the shoulder joint in a patient with rheumatoid arthritis after 4 years of treatment with etanercept 査読

Toshifumi Ozaki, Kenzo Hashizume, Ryuichi Nakahara, Keiichiro Nishida

MODERN RHEUMATOLOGY 22 ( 4 ) 635 - 637 2012年8月

メカニカルストレスによる軟骨基質分解酵素発現に対するヒストン脱アセチル化酵素阻害薬の抑制効果

斎藤太一, 西田圭一郎, 古松毅之, 小澤正嗣, 金澤智子, 原田遼三, 尾崎敏文

日本整形外科学会雑誌 86 ( 8 ) S1219 - S1219 2012年8月

3D-CADシステムを用いた鎖骨の三次元形状比較

中原龍一, 野田知之, 島村安則, 橋詰謙三, 西田圭一郎, 尾崎敏文

骨折 34 ( 2 ) 265 - 268 2012年5月

記述言語：日本語出版者・発行元：(一社)日本骨折治療学会

【目的】当院では骨折症例に対してCT画像をもとに健側鏡像の立体模型か実寸大の左右反転図を作成し、プレベンディングを行っている。この方法は骨の左右差が少ないことを前提としているが、どの程度骨の左右差があるかは不明であった。そこでCADソフトを用いてCT画像を三次元的に比較するシステムを構築し、プレベンディング法を最も利用している鎖骨を対象に左右差を検討した。【方法と対象】解剖実習で摘出した屍体の左右の鎖骨16対をCTで撮影し、CADソフトを用いて三次元的な左右差を検討した。【結果】骨幹部のカーブ形状に左右差は少なかったが、径の左右差は認められた。【考察】径の左右差はあるがカーブ形状に左右差はなかったため、鎖骨に関してプレベンディングは有用であると考えられた。(著者抄録)

中原龍一, 西田圭一郎

からだの科学 ( 273 ) 31 - 35 2012年5月

【RAの新分類基準の時代におけるリウマチ性疾患の鑑別】非結核性抗酸菌による関節炎・腱滑膜炎

那須義久, 西田圭一郎

リウマチ科 47 ( 4 ) 379 - 384 2012年4月

リウマチ性疾患の画像(1) T2マッピング解析法複数シークエンス画像を用いた軟骨半自動抽出法

中原龍一, 西田圭一郎, 橋詰謙三, 小澤正嗣, 斉藤太一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 292 - 292 2012年3月

関節リウマチ手術の長期成績関節リウマチ手術の長期成績人工肘関節置換術 linked vs.unlinked

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 214 - 214 2012年3月

関節リウマチの手術下肢(1) 関節リウマチ(RA)患者の外反母趾に対する切除関節形成術の治療成績

金澤智子, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 小澤正嗣, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 393 - 393 2012年3月

リウマチ性疾患の画像(1) 関節リウマチにおける大関節破壊の新たな画像評価基準(ARASHI status score)に関する検討

那須義久, 西田圭一郎, 高杉幸司, 山下美鈴, 棗田将光, 江澤香代, 江澤和彦, 金澤智子, 斉藤太一, 小澤正嗣, 中原龍一, 橋詰謙三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 292 - 292 2012年3月

メカニカルストレス下におけるヒストン脱アセチル化酵素阻害薬による軟骨破壊抑制効果

斉藤太一, 西田圭一郎, 橋詰謙三, 中原龍一, 小澤正嗣, 金澤智子

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 551 - 551 2012年3月

関節リウマチの手術下肢(1) 関節リウマチの足関節、中後足部変形に対する治療成績

小澤正嗣, 西田圭一郎, 橋詰謙三, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 393 - 393 2012年3月

MTXの有効性と安全性画像的にみたMTXの有効性と限界への対応

西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 56回・21回 168 - 168 2012年3月

関節リウマチの手関節に対する部分固定術の術後成績

斎藤太一, 西田圭一郎, 橋詰謙三, 島村安則, 尾崎敏文

日本手外科学会雑誌 29 ( 1 ) S134 - S134 2012年3月

当院における人工肘関節再置換術の術後成績

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 原田遼三, 尾崎敏文

日本肘関節学会雑誌 19 ( 1 ) S24 - S24 2012年1月

Gene Expression and Localization of High-mobility Group Box Chromosomal Protein-1 (HMGB-1) in Human Osteoarthritic Cartilage

Chuji Terada, Aki Yoshida, Yoshihisa Nasu, Shuji Mori, Yasuko Tomono, Masato Tanaka, Hideo K. Takahashi, Masahiro Nishibori, Toshifumi Ozaki, Keiichiro Nishida

ACTA MEDICA OKAYAMA 65 ( 6 ) 369 - 377 2011年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We investigated the expression and localization of high-mobility group box chromosomal protein-1 (HMGB-1) in human osteoarthritic (OA) cartilage in relation to the histopathological grade of cartilage destruction, and examined the role of HMGB-1 in the regulation of proinflammatory cytokine expression in chondrocytes. An immunohistochemical study demonstrated that total HMGB-1-positive cell ratios increase as the Osteoarthritis Research Society International (OARSI) histological grade increased. The population of cytoplasmic HMGB-1-positive chondrocytes was especially increased in the deep layers of higher-grade cartilage. The ratios and localization of receptors for advanced glycation end products (RAGE) expression by chondrocytes in Grade 2, 3, and 4 were significantly higher than those in Grade 1. In vitro stimulation with IL-1 beta, but not TNF alpha, significantly upregulated the expression of HMGB-1 mRNA by human OA chondrocytes. Both IL-1 beta and TNFa promoted the translocation of HMGB-1 from nuclei to cytoplasm. IL-1 beta and TNF alpha secretions were stimulated at higher levels of HMGB-1. The results of our study suggest the involvement of HMGB-1 in the pathogenesis of cartilage destruction in OA.

DOI： 10.18926/AMO/47262

Risk of postoperative complications in rheumatoid arthritis relevant to treatment with biologic agents: a report from the Committee on Arthritis of the Japanese Orthopaedic Association

Masahiko Suzuki, Keiichiro Nishida, Satoshi Soen, Hiromi Oda, Hiroshi Inoue, Atsushi Kaneko, Kenji Takagishi, Takaaki Tanaka, Tsukasa Matsubara, Naoto Mitsugi, Yuichi Mochida, Shigeki Momohara, Toshihito Mori, Toru Suguro

JOURNAL OF ORTHOPAEDIC SCIENCE 16 ( 6 ) 778 - 784 2011年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER JAPAN KK

Since biologic agents were introduced to treat rheumatoid arthritis (RA) in 2003, the number of orthopedic surgical procedures under treatment with biologic agents has been increasing in Japan. However, whether biologic agents cause an increase in the prevalence of postoperative complications is as yet unknown. The Committee on Arthritis of the Japanese Orthopedic Association investigated the prevalence of postoperative complications in patients with RA in teaching hospitals in Japan.
Between January 2004 and November 2008, surveillance forms about medications and surgical procedures in patients with RA were sent to 2,019 teaching hospitals. Data were analyzed by the Rheumatoid Arthritis Committee.
Biologic agents were administered to RA patients in 632 of 1,245 hospitals (50.8%); 430 of the 1,245 hospitals (34.5%) used surgical intervention under treatment with biologic agents. The number of surgical procedures under treatment with biologic agents was 3,468, and the prevalence of infection was 1.3% (46 cases). The prevalence of infection was 1.0% (567 procedures) in 56,339 procedures under treatment with nonbiologic disease-modifying anti-rheumatic drugs. There were no significant differences between biological and nonbiological treatment groups with respect to the prevalence of infection. In the joint arthroplasty group, the number of procedures under biological and nonbiological treatment was 1,626 and 29,903, and the prevalence of infection was 2.1% (34 procedures) and 1.0% (298 procedures), respectively. There was a significant difference between groups. The odds ratio was 2.12 (95% confidence interval 1.48-3.03, P < 0.0001).
The chance of having biological treatment with joint arthroplasty was more than twofold greater in patients with surgical-site infections compared with those treated with nonbiologic agents. Caution is required for surgical procedure, perioperative course, and obtaining consent for joint arthroplasty for patients with RA undergoing surgery under biological agents.

DOI： 10.1007/s00776-011-0142-3

関節リウマチ(RA)患者の外反母趾に対する切除関節形成術の治療成績

金澤智子, 橋詰謙三, 西田圭一郎, 中原龍一, 斉藤太一, 小澤正嗣, 尾崎敏文

日本関節病学会誌 30 ( 3 ) 264 - 264 2011年10月

整形外科CT画像の三次元ディスプレー表示システムの有用性

中原龍一, 西田圭一郎, 金澤智子, 小澤正嗣, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 30 ( 3 ) 368 - 368 2011年10月

生物学的製剤導入とRAの手術 RA上肢の手術

西田圭一郎, 橋詰謙三, 中原龍一, 金澤智子, 斎藤太一, 小澤正嗣, 尾崎敏文

日本関節病学会誌 30 ( 3 ) 250 - 250 2011年10月

関節リウマチにおける大関節破壊の新たな画像評価(ARASHI status score)に関する検討

那須義久, 西田圭一郎, 金澤智子, 斎藤太一, 中原龍一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 30 ( 3 ) 372 - 372 2011年10月

タクロリムス使用下に術後感染症を生じた関節リウマチの3例

橋詰謙三, 西田圭一郎, 中原龍一, 斉藤太一, 金澤智子, 小澤正嗣, 尾崎敏文

日本関節病学会誌 30 ( 3 ) 374 - 374 2011年10月

骨折治療への三次元実体模型の応用

中原龍一, 野田知之, 島村安則, 西山武, 西田圭一郎, 尾崎敏文

骨折 33 ( 3 ) 738 - 742 2011年9月

記述言語：日本語出版者・発行元：(一社)日本骨折治療学会

【目的】CT画像から作製された三次元実体模型が手術に利用されるようになった。しかし、発注が煩雑で作製時間が長いことが問題であった。当院では作製過程に医師が加わることで作業効率を改善し、骨折などの緊急症例に対応可能な院内発注システムを構築したので報告する。【方法】当院には三次元プリンターが設置されており、歯科技工士が実体模型を作製していた。医師がCTデータから領域抽出を行いDICOMデータとして保存したものを、作製期限を設けてデータを蓄積し、作製期限に間に合うように一度にまとめて作製するシステムを構築した。【結果】作業効率が改善され緊急作製に対応可能となった。2009年度は緊急作製を必要とした骨折症例7例で48時間以内にプレベンディング用の健側骨の左右反転模型を作製した。【結語】領域抽出と作製を分離することで作製効率が向上し、緊急症例に対応可能となった。(著者抄録)

Recent trends in orthopedic surgery performed in Japan for rheumatoid arthritis

Shigeki Momohara, Sakae Tanaka, Hiroshi Nakamura, Junya Mibe, Takuji Iwamoto, Katsunori Ikari, Jinju Nishino, Yuho Kadono, Tetsuro Yasui, Kenji Takahashi, Kenji Takenouchi, Kenzo Hashizume, Ryuichi Nakahara, Ayako Kubota, Takashi Nakamura, Keiichiro Nishida, Toru Suguro

MODERN RHEUMATOLOGY 21 ( 4 ) 337 - 342 2011年8月

記述言語：英語出版者・発行元：SPRINGER

The aim of this report was to review the use of orthopedic surgeries performed to manage rheumatoid arthritis (RA). Our review of studies published in English indicates that there has been a decrease in RA-associated surgeries in Western countries. Improvements in medical treatment may partly explain the reduction in numbers of orthopedic joint surgeries, which also suggests a worldwide trend toward improved long-term outcomes. However, the results of our multicenter study in Japan indicate that the number of RA-associated operations has not decreased, and that the numbers of operations performed annually have been relatively stable from 1998 to 2008. Although there definitely has been a decline in the numbers of synovectomy surgeries, the numbers of operations on the upper limbs and foot arthroplasties have increased. With the trend toward milder disease because of improved medical treatment, we speculate that RA patients may want and need better function for the activities of daily living. The combination of medical treatment and surgical intervention is thought to improve outcomes in RA patients who will develop joint destruction. Additional studies, including analyses of RA databases containing long-term data on a variety of surgical interventions, are needed.

DOI： 10.1007/s10165-011-0426-7

MRI画像表示法カラー表示を用いて異なるシークエンス画像を同時に表示させる方法

中原龍一, 金澤智子, 齋藤太一, 橋詰謙三, 西田圭一郎, 尾崎敏文

日本整形外科学会雑誌 85 ( 8 ) S1226 - S1226 2011年8月

リウマチ手変形に対する治療関節リウマチ手指MP関節に対する人工指関節置換術の成績

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

関節の外科 38 ( 2 ) 47 - 47 2011年8月

メカニカルストレス下におけるヒストン脱アセチル化酵素阻害薬による軟骨破壊抑制効果

齋藤太一, 西田圭一郎, 小澤正嗣, 古松毅之, 鉄永智紀, 尾崎敏文

日本整形外科学会雑誌 85 ( 8 ) S1158 - S1158 2011年8月

リウマチ外科治療up-to-date(新評議員報告) PROSNAP人工肘関節の短期臨床成績

西田圭一郎, 橋詰謙三, 中原龍一, 斎藤太一, 金澤智子, 那須義久, 尾崎敏文

関節の外科 38 ( 2 ) 58 - 58 2011年8月

上腕骨通顆骨折に対する内固定法の力学的比較 ONI plate対従来固定法

島村安則, 今谷潤也, 野田知之, 中原龍一, 齋藤太一, 金澤智子, 井上円加, 小澤正嗣, 古松毅之, 国定俊之, 西田圭一郎, 橋詰博行, 尾崎敏文

日本整形外科学会雑誌 85 ( 8 ) S1338 - S1338 2011年8月

橈骨遠位掌側面の横断面での傾きの変化

清水弘毅, 今谷潤也, 竹下歩, 堀田昌宏, 大塚亮介, 中道亮, 山川泰明, 川上幸雄, 林正典, 西田圭一郎

骨折 33 ( Suppl. ) S55 - S55 2011年7月

[Cutting edge on research of cartilage metabolism. Recent progress in bio-molecular imaging of articular cartilage]. 査読

Toshitaka Oohashi, Keiichiro Nishida

Clinical calcium 21 ( 6 ) 896 - 902 2011年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

In the process of cartilage degeneration seen in osteoarthritis, loss of proteoglycan from articular cartilage has been widely accepted as a critical early event, followed by collagen degradation designated as a point of no return. Recent advance in the development of targeted molecular probes and new imaging modalities enabled the detection of qualitative and functional change of articular cartilage. In this paper, we describe the recent progress of bio-molecular imaging of articular cartilage including our fluorescent-labeled glycosaminoglycan-binding octaarginine.

ENU-induced missense mutation in the C-propeptide coding region of Col2a1 creates a mouse model of platyspondylic lethal skeletal dysplasia, Torrance type

Tatsuya Furuichi, Hiroshi Masuya, Tomohiko Murakami, Keiichiro Nishida, Gen Nishimura, Tomohiro Suzuki, Kazunori Imaizumi, Takashi Kudo, Kiyoshi Ohkawa, Shigeharu Wakana, Shiro Ikegawa

MAMMALIAN GENOME 22 ( 5-6 ) 318 - 328 2011年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The COL2A1 gene encodes the alpha 1(II) chain of the homotrimeric type II collagen, the most abundant protein in cartilage. In humans, COL2A1 mutations create many clinical phenotypes collectively termed type II collagenopathies; however, the genetic basis of the phenotypic diversity is not well elucidated. Therefore, animal models corresponding to multiple type II collagenopathies are required. In this study we identified a novel Col2a1 missense mutation-c.44406A > C (p.D1469A)-produced by large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis in a mouse line. This mutation was located in the C-propeptide coding region of Col2a1 and in the positions corresponding to a human Col2a1 mutation responsible for platyspondylic lethal skeletal dysplasia, Torrance type (PLSD-T). The phenotype was inherited as a semidominant trait. The heterozygotes were mildly but significantly smaller than wild-type mice. The homozygotes exhibited lethal skeletal dysplasias, including extremely short limbs, severe spondylar dysplasia, severe pelvic hypoplasia, and brachydactyly. As expected, these skeletal defects in the homozygotes were similar to those in PLSD-T patients. The secretion of the mutant proteins into the extracellular space was disrupted, accompanied by abnormally expanded rough endoplasmic reticulum (ER) and upregulation of ER stress-related genes, such as Grp94 and Chop, in chondrocytes. These findings suggested that the accumulation of mutant type II collagen in the ER and subsequent induction of ER stress are involved, at least in part in the PLSD-T-like phenotypes of the mutants. This mutant should serve as a good model for studying PLSD-T pathogenesis and the mechanisms that create the great diversity of type II collagenopathies.

DOI： 10.1007/s00335-011-9329-3

生物学的製剤と外科治療生物学的製剤使用患者の手術のタイミング

西田圭一郎, 金澤智子, 中原龍一, 橋詰謙三, 那須義久, 斎藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 147 - 147 2011年6月

関節リウマチの手術上肢関節リウマチ(RA)に対するSauve-Kapandji法の治療成績

金澤智子, 橋詰謙三, 西田圭一郎, 中原龍一, 斉藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 383 - 383 2011年6月

関節リウマチの手術上肢 RA手関節に対する部分固定術の術後成績

斉藤太一, 西田圭一郎, 橋詰謙三, 中原龍一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 312 - 312 2011年6月

関節リウマチの手術上肢関節リウマチ手指MP関節に対する人工指関節置換術の成績

橋詰謙三, 西田圭一郎, 那須義久, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 55回・20回 310 - 310 2011年6月

炎症標的化金コロイド内包リポソームのリウマチ関節炎症部位への集積

古谷満寿美, 松本衣未, 美名口順, 小川弘子, 古松毅之, 廣畑聡, 二宮善文, 西田圭一郎, 大塚愛二, 大橋俊孝

日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集 43回・58回 118 - 118 2011年5月

Increased level of heme oxygenase-1 in rheumatoid arthritis synovial fluid

Ai Kitamura, Keiichiro Nishida, Takamitsu Komiyama, Hideyuki Doi, Yasutaka Kadota, Aki Yoshida, Toshifumi Ozaki

MODERN RHEUMATOLOGY 21 ( 2 ) 150 - 157 2011年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

We investigated the expression and localization of heme oxygenase-1 (HO-1) in synovial fluid and synovial tissue, and examined the stimulation of HO-1 production in rheumatoid synovial fibroblasts (RASFs). Synovial fluid samples were obtained from knee joints of 20 rheumatoid arthritis (RA) and 20 osteoarthritis (OA) patients, and concentration of HO-1 and matrix metalloproteinase-3 (MMP-3) were measured by enzyme-linked immunosorbent assay (ELISA). Synovial tissues obtained from RA or OA patients during total knee arthroplasty (TKA) were used for immunohistochemical analysis of HO-1. HO-1 production by RASFs in response to various cytokines was examined by ELISA. HO-1 levels in synovial fluid were higher in the RA group than in the OA group with significant difference (P < 0.001), and correlated with serum C-reactive protein (CRP) level (r = 0.80, P < 0.01) in the RA group. Higher levels of HO-1 were seen in the RA-L group (Larsen grade III-V) than in the RA-E (Larsen grade 0-II) group (P < 0.001). There was weak correlation between the levels of HO-1 protein and MMP-3 in synovial fluid in the RA group (r = 0.31, P < 0.01), while no positive correlation was observed in OA. Positive immunoreaction for HO-1 was observed in cells of synovial tissue including synovial fibroblasts and cells in synovial pannus. HO-1 protein levels in cultured media of RASFs were increased by stimulation by interleukin-1 beta at 6 h and tumor necrosis factor-alpha at 12 h, but suppressed by interferon-gamma at 12 and 24 h. These results indicated that HO-1 expression in synovial tissue might be stimulated by inflammatory cytokines. The correlation of HO-1 concentration in synovial fluid with serum CRP and MMP-3 in joint fluid indicated that HO-1 might be useful as a marker of joint inflammation in RA patients.

DOI： 10.1007/s10165-010-0372-9

掌側プレート固定を行った橈骨遠位端骨折における抜釘術の重要性

ハンドル外傷による舟状骨骨折の1例

金澤智子, 島村安則, 西田圭一郎, 斎藤太一, 中原龍一, 雑賀建多, 野田知之, 尾崎敏文

中国・四国整形外科学会雑誌 23 ( 1 ) 253 - 253 2011年4月

島村安則, 井上円加, 小澤正嗣, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 23 ( 1 ) 258 - 258 2011年4月

RA手関節に対する部分固定術の術後成績

斎藤太一, 西田圭一郎, 橋詰謙三, 島村安則, 尾崎敏文

日本手外科学会雑誌 28 ( 1 ) S138 - S138 2011年3月

ANTERIOR TRANSPOSITION OF THE ULNAR NERVE WITH ENDOSCOPIC ASSISTANCE

T. Konishiike, K. Nishida, M. Ozawa, T. Ozaki

JOURNAL OF HAND SURGERY-EUROPEAN VOLUME 36E ( 2 ) 126 - 129 2011年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SAGE PUBLICATIONS LTD

We treated 20 patients with cubital tunnel syndrome by anterior transposition of the ulnar nerve with endoscopic assistance. Five elbows were classified preoperatively as McGowan's stage 1, 11 as stage 2 and four as stage 3. Excellent outcomes were obtained in nine and good in eight patients. Three patients had fair results. Improvement of symptoms occurred in all patients. There were no serious complications. All ulnar nerves remained anteriorly transposed.

DOI： 10.1177/1753193410381675

Prenatal diagnosis of short-rib polydactyly syndrome type 3 (Verma-Naumoff type) by three-dimensional helical computed tomography

Takahiro Yamada, Gen Nishimura, Keiichiro Nishida, Hideaki Sawai, Tokuhiko Omatsu, Taichi Kimura, Hiroshi Nishihara, Rina Shono, Shigeki Shimada, Mamoru Morikawa, Masato Mizushima, Takashi Yamada, Kazutoshi Cho, Shinya Tanaka, Hiroki Shirato, Hisanori Minakami

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 37 ( 2 ) 151 - 155 2011年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-BLACKWELL PUBLISHING, INC

We present a case of short-rib polydactyly syndrome (SRPs) type 3 in which accurate prenatal diagnosis was feasible using both ultrasonography and 3D-CT. SRP encompass a heterogeneous group of lethal skeletal dysplasias. However, the phenotypes overlap with those of nonlethal skeletal dysplasias (i.e. Ellis-van Creveld syndrome and Jeune syndrome). As accurate prenatal diagnosis of SRP is helpful for parents, we used 3D-CT in the early third trimester to examine a fetus suggested to have phenotypes of 'short-rib dysplasia group' on ultrasonography. 3D-CT showed mild modification of the vertebral bodies, small ilia with horizontal acetabula and triangular partial ossification defects, and subtle metaphyseal irregularities of the femora. These CT findings and an extensive literature search regarding the phenotypes of various diseases categorized as short-rib dysplasia group led to a correct prenatal diagnosis of SRP type 3. This case exemplified the usefulness of 3D-CT for the precise prenatal diagnosis of skeletal dysplasias.

DOI： 10.1111/j.1447-0756.2010.01324.x

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

T. Tetsunaga, K. Nishida, T. Furumatsu, K. Naruse, S. Hirohata, A. Yoshida, T. Saito, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE 19 ( 2 ) 222 - 232 2011年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：W B SAUNDERS CO LTD

Objective: To investigate the mechanism of mechanical stress-induced expression and regulation of aggrecanases and examine the role of runt-related transcription factor 2 (RUNX-2) in chondrocyte-like cells.
Methods: SW1353 cells were seeded onto stretch chambers at a concentration of 5 x 10(4) cells/chamber, and a uni-axial cyclic tensile strain (CTS) (0.5 Hz, 10% stretch) was applied for 30 min. Total RNA was extracted, reverse transcribed, and analyzed by polymerase chain reaction (PCR) and real-time PCR. RUNX-2 overexpression and small interfering RNA (siRNA) targeting RUNX-2 were used to investigate the role of RUNX-2 in CTS-induced gene expression. The involvement of diverse mitogen-activated protein kinase (MAPK) pathways in the activation of RUNX-2, MMP-13 and ADAMTS-5 during CTS was examined by Western blotting.
Results: CTS induced expression of RUNX-2, MMP-13, ADAMTS-4, -5, and -9. Overexpression of RUNX-2 up-regulated expression of MMP-13 and ADAMTS-5, whereas RUNX-2 siRNA resulted in significant down-regulation of mechanically-induced MMP-13 and ADAMTS-5 expression. CTS induced activation of p38 MAPK, and CTS induction of RUNX-2. MMP-13 and ADAMTS-5 mRNA was down-regulated by the selective p38 MAPK inhibitor SB203580 but not by the p44/42 MAPK inhibitor U0126, or the JNK MAPK inhibitor JNK inhibitor II.
Conclusions: RUNX-2 might have a role as a key downstream mediator of p38's ability to regulate mechanical stress-induced MMP-13 and ADAMTS-5 expression. (C) 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.joca.2010.11.004

当院にて経験したＷｅｌｌｌｅｇｃｏｍｐａｒｔｍｅｎｔｓｙｎｄｒｏｍｅの１例

岡田芳樹, 橋詰謙三, 中原龍一, 西田圭一郎, 野田知之, 尾﨑敏文

中部日本整形外科災害外科学会雑誌 54 ( 4 ) 869 - 870 2011年

Time-concentration profile of serum etanercept in Japanese patients with rheumatoid arthritis after treatment discontinuation before orthopedic surgery

Keiichiro Nishida, Kenzo Hashizume, Yasutaka Kadota, Masamitsu Natsumeda, Ryuichi Nakahara, Taichi Saito, Tomoko Kanazawa, Kazuhiko Ezawa, Toshihumi Ozaki

MODERN RHEUMATOLOGY 20 ( 6 ) 637 - 639 2010年12月

長橈側手根伸筋(ECRL)腱を用いて母指手根中手骨(CM)関節形成術を行った1例

井上円加, 西田圭一郎, 橋詰謙三, 島村安則, 中原龍一, 斉藤太一, 金澤智子, 尾崎敏文

岡山医学会雑誌 122 ( 3 ) 279 - 279 2010年12月

【関節リウマチ明確な治療目標の達成をめざす診療】パラダイムシフト後の関節外科治療

那須義久, 中原龍一, 西田圭一郎

治療学 44 ( 10 ) 1127 - 1130 2010年10月

RA上肢変形の治療関節リウマチ(RA)に対するSauve-Kapandji(S-K)法の治療成績

金澤智子, 橋詰謙三, 西田圭一郎, 中原龍一, 斎藤太一, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 398 - 398 2010年10月

周術期の管理エタネルセプト使用症例の周術期感染頻度の検討

中原龍一, 西田圭一郎, 金澤智子, 斎藤太一, 橋詰謙三, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 340 - 340 2010年10月

関節病に対する上肢人工関節置換術関節リウマチ肘関節破壊に対するJACE型人工肘関節置換術の中期成績

橋詰謙三, 西田圭一郎, 中原龍一, 斎藤太一, 金澤智子, 尾崎敏文

日本関節病学会誌 29 ( 3 ) 409 - 409 2010年10月

橈骨遠位端掌側部の組織学的検討いわゆるWatershed Lineを中心に

今谷潤也, 清水弘毅, 高田逸朗, 西田圭一郎, 秋田恵一

日本手外科学会雑誌 26 ( 5 ) 466 - 468 2010年9月

三次元実体石膏模型を利用して治療した反復性肩関節脱臼の1例

井上円加, 中原龍一, 斎藤太一, 金澤智子, 島村安則, 小澤正嗣, 阿部信寛, 野田知之, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 176 - 176 2010年9月

鎖骨骨幹部骨折に対する前下方プレート法による治療成績

島村安則, 野田知之, 中原龍一, 金澤智子, 井上円加, 斎藤太一, 小澤正嗣, 雑賀建多, 西田圭一郎, 尾崎敏文

肩関節 35 ( 1 ) 75 - 75 2010年9月

橈骨遠位端掌側ロッキングプレートにおける屈筋腱障害の発生要因解剖学的検討を基に

清水弘毅, 今谷潤也, 高田逸朗, 中道亮, 山川泰明, 大塚亮介, 岡田幸正, 井上円加, 川上幸雄, 林正典, 西田圭一郎

中国・四国整形外科学会雑誌 22 ( 2 ) 496 - 496 2010年9月

ヒト軟骨細胞様細胞においてADAMTS-5はRUNX-2を介してメカノセンシティブに機能するアグリカナーゼである

鉄永智紀, 西田圭一郎, 古松毅之, 斎藤太一, 成瀬恵治, 尾崎敏文

日本整形外科学会雑誌 84 ( 8 ) S1230 - S1230 2010年8月

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis

Tomoko Kawabata, Keiichiro Nishida, Koji Takasugi, Hiroko Ogawa, Kenei Sada, Yasutaka Kadota, Junko Inagaki, Satoshi Hirohata, Yoshifumi Ninomiya, Hirofumi Makino

Arthritis Research and Therapy 12 ( 4 ) 637 - 639 2010年7月

記述言語：英語掲載種別：研究論文（学術雑誌）

Introduction: The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA), and to examine whether there is a link between HDAC activity and synovial inflammation.Methods: HDAC activity and histone acetyltransferase (HAT) activity were determined in nuclear extracts of total synovial tissue surgically obtained from normal, OA and RA joints. The level of cytoplasmic tumor necrosis factor a (TNFα) fraction was measured by ELISA. Total RNA of synovial tissue was used for RT-PCR of HDAC1-8. In synovial fibroblasts from RA (RASFs), the effects of TNFα on nuclear HDAC activity and class I HDACs (1, 2, 3, 8) mRNA expressions were examined by quantitative real-time PCR. The protein expression and distribution of class I HDACs were examined by Western blotting.Results: Nuclear HDAC activity was significantly higher in RA than in OA and normal controls and correlated with the amount of cytoplasmic TNFα. The mRNA expression of HDAC1 in RA synovial tissue was higher than in OA and normal controls, and showed positive correlation with TNFα mRNA expression. The protein level of nuclear HDAC1 was higher in RA synovial tissue compared with OA synovial tissue. Stimulation with TNFα significantly increased the nuclear HDAC activity and HDAC1 mRNA expression at 24 hours and HDAC1 protein expression at 48 hours in RASFs.Conclusions: Our results showed nuclear HDAC activity and expression of HDAC1 were significantly higher in RA than in OA synovial tissues, and they were upregulated by TNFα stimulation in RASFs. These data might provide important clues for the development of specific small molecule HDAC inhibitors. © 2010 Kawabata et al.
licensee BioMed Central Ltd.

DOI： 10.1186/ar3071

Radiographic measurements in the evaluation and classification of elbow joint destruction in patients with rheumatoid arthritis

Kenzo Hashizume, Keiichiro Nishida, Kazuo Fujiwara, Yasutaka Kadota, Ryuichi Nakahara, Kazuhiko Ezawa, Hajime Inoue, Toshifumi Ozaki

CLINICAL RHEUMATOLOGY 29 ( 6 ) 637 - 643 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER LONDON LTD

We developed two new radiographic parameters-the humeral surface height ratio and ulnar surface height ratio-to precisely detect changes in the bony structure of rheumatoid elbows. Of the 59 patients with rheumatoid arthritis, 101 elbows were classified into four types (osteoarthritis, ankylosis, erosive, and resorptive) according to the radiographic appearance. Clinically, osteoarthritis type and ankylosis type were considered to be stable form, and erosive type and resorptive type were unstable form. Patients' clinical data and yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and ulnar surface height ratio were compared among the four types and between the two forms. There were significant differences between the two forms and among the three types except for the ankylosis type in yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and ulnar surface height ratio. Stable and unstable forms were distinguished by a cut-off point of 0.65 and 2.58 in yearly radiographic changes in the bony structure evaluated by the humeral surface height ratio and the ulnar surface height ratio, respectively. These parameters might be useful for monitoring the structural changes of the elbow joint in rheumatoid arthritis.

DOI： 10.1007/s10067-010-1381-y

Preoperative Time Required for the Timed "Up and Go" Test in Women with Hip Osteoarthritis Could Predict a Deep Venous Thrombosis Complication after Total Hip Arthroplasty

Kentaro Sasaki, Masuo Senda, Keiichiro Nishida, Haruyuki Ota

ACTA MEDICA OKAYAMA 64 ( 3 ) 197 - 201 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We examined whether the preoperative time required for the Timed "Up and Go" (TUG) test could predict the risk for deep venous thrombosis (DVT) in patients with hip osteoarthritis after total hip arthroplasty (THA). Eighteen patients with DVT diagnosed by venography were selected, and 18 without DVT of the same age and sex and with the same operated side as the DVT group were selected as a control group. We evaluated the 5 preoperative factors that might affect the occurrence of DVT complications, as follows: disease duration, body mass index, serum total cholesterol, subjective pain evaluated by the visual analog scale, and TUG. The JOA hip score (pain, range of motion, walking ability, and daily life) was also evaluated before surgery. As a postoperative factor, we checked the postoperative day when weight-bearing was initiated. As a result, TUG (DVT, 18.4 +/- 4.0 sec vs. control, 15.0 +/- 3.2 sec; p < 0.01) was only significantly different between the 2 groups. The ROC curve revealed that the cut-off point of 15.3 sec in preoperative time for TUG was sensitive (83.3%) and specific (61.1%) for DVT after THA (odds ratio = 7.0; 95% confidence interval, 1.6-30.8). These results suggested that low preoperative ambulatory ability in patients with hip osteoarthritis might be associated with DVT after THA. An improvement in TUG before surgery might contribute to a decrease in the occurrence of DVT after THA.

DOI： 10.18926/AMO/40012

The Mohawk homeobox gene is a critical regulator of tendon differentiation

Yoshiaki Ito, Naoya Toriuchi, Teruhito Yoshitaka, Hiroe Ueno-Kudoh, Tempei Sato, Shigetoshi Yokoyama, Keiichiro Nishida, Takayuki Akimoto, Michiko Takahashi, Shigeru Miyaki, Hiroshi Asahara

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107 ( 23 ) 10538 - 10542 2010年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATL ACAD SCIENCES

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

DOI： 10.1073/pnas.1000525107

Biomechanical Evaluation of the Fixation Methods for Transcondylar Fracture of the Humerus: ONI Plate Versus Conventional Plates and Screws

Yasunori Shimamura, Keiichiro Nishida, Junya Imatani, Tomoyuki Noda, Hiroyuki Hashizume, Aiji Ohtsuka, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 64 ( 2 ) 115 - 120 2010年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We biomechanically evaluated the bone fixation rigidity of an ONI plate (Group I) during fixation of experimentally created transcondylar humerus fractures in cadaveric elbows, which are the most frequently observed humeral fractures in the elderly, and compared it with the rigidity achieved by 3 conventional fixation methods: an LCP reconstruction plate 3.5 using a locking mechanism (Group II), a conventional reconstruction plate 3.5 (CRP) with a cannulated cancellous screw (Group III), and a CRP with 2 cannulated cancellous screws (CS) in a crisscross orientation (Group IV). In the axial loading test, the mean failure loads were: Group I, 98.9 +/- 32.6; Group II, 108.5 +/- 27.2; Group III, 50.0 +/- 7.5; and Group IV, 34.5 +/- 12.2 (N). Group I fixations failed at a significantly higher load than those of Groups III and IV (p < 0.05). In the extension loading test, the mean failure loads were: Group I, 34.0 +/- 12.4; Group II, 51.0 +/- 14.8; Group III, 19.3 +/- 6.0; and Group IV, 14.7 +/- 3.1 (N). Group IV fixations showed a significantly lower failure load than those of Group I (p < 0.05). The fixation rigidities against mechanical loading by the ONI plate and LCP plate were comparable. These results suggested that an ONI system might be superior to the CRP and CS method, and comparable to the LCP method in terms of fixation rigidity for distal humerus fractures.

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 金澤智子, 中原龍一, 雑賀建多, 野田知之, 西田圭一郎, 尾崎敏文

中国・四国整形外科学会雑誌 22 ( 1 ) 199 - 199 2010年4月

橈骨遠位端部掌側の解剖的研究 Watershed Lineを中心に

清水弘毅, 今谷潤也, 中道亮, 井上円加, 岡田幸正, 高田逸朗, 高橋欣吾, 川上幸雄, 林正典, 西田圭一郎, 吉田晶

中国・四国整形外科学会雑誌 22 ( 1 ) 260 - 260 2010年4月

生物学的製剤使用下の手術治療について生物学的製剤の限界

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S228 - S228 2010年3月

掌側ロッキングプレートを用いて加療した橈骨遠位部骨折における抜釘術の検討

島村安則, 斎藤太一, 野田知之, 西田圭一郎, 尾崎敏文

日本手の外科学会雑誌 27 ( 1 ) S138 - S138 2010年3月

生物学的製剤時代における手術の変遷画像診断と外科的治療画像からみた手術の適応とタイミングどの時期に手術が必要か

西田圭一郎, 橋詰謙三, 中原龍一, 門田康孝, 那須義久, 斎藤太一, 尾崎敏文

日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集 54回・19回 219 - 219 2010年3月

関節リウマチに対する手術療法の進歩と今後関節リウマチに対する上肢手術の進歩と今後

西田圭一郎, 橋詰謙三, 門田康孝, 中原龍一, 斎藤太一, 尾崎敏文

日本整形外科学会雑誌 84 ( 3 ) S231 - S231 2010年3月

Frequent methylation of RASSF１A in synovial sarcoma and the anti-tumor effects of 5-aza-2'-deoxycytidine against synovial sarcoma cell lines.

Numoto K, Yoshida A, Sugihara S, Kunisada T, Morimoto Y, Yoneda Y, Fujita Y, Nishida K, Ouchida M, Ozaki T

J Cancer Res Clin Oncol 136 ( 1 ) 17 - 25 2010年1月

Inflammatory Cytokine-induced Expression of Vasohibin-1 by Rheumatoid Synovial Fibroblasts

Kohei Miyake, Keiichiro Nishida, Yasutaka Kadota, Hiroko Yamasaki, Tatsuyo Nasu, Daisuke Saitou, Katsuyuki Tanabe, Hikaru Sonoda, Yasufumi Sato, Yohei Maeshima, Hirofumi Makino

ACTA MEDICA OKAYAMA 63 ( 6 ) 349 - 358 2009年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Angriogenesis is an essential event in the development of synovial inflammation in rheumatoid arthritis (RA). The aim of the current study was to investigate the expression of vasohibin-1, a novel endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor, in the RA synovium, and to test the effect of inflammatory cytokines on the expression of vasohibin-1 by RA synovial fibroblasts (RASFs). Synovial tissue samples were obtained at surgery from patients with osteoarthritis (OA) and RA, and subjected to immunohistochemistry to investigate the expression and distribution of vasohibin-1 relevant to the degree of synovial inflammation. In an in vitro analysis, RASFs were used to examine the expression of vasohibin-1 and VEGF mRNA by real-time PCR after stimulation with VEGF or inflammatory cytokines under normoxic or hypoxic conditions. The immunohistochemical results showed that vasohibin-1 was expressed in synovial lining cells, endothelial cells, and synovial fibroblasts. In synovial tissue, there was a significant correlation between the expression of vasohibin-1 and histological inflammation score (p = 0.002, r = 0.842). In vitro, stimulation with VEGF induced the expression of vasohibin-1 mRNA in RASFs under normoxic conditions, and stimulation with cytokines induced vasohibin-1 mRNA expression under a hypoxic condition. These results suggest that vasohibin-1 was expressed in RA synovial tissue and might be regulated by inflammatory cytokines.

DOI： 10.18926/AMO/31820

Computer Navigation-Assisted Spinal Fusion with Segmental Pedicle Screw Instrumentation for Scoliosis with Rett Syndrome: A Case Report

Masato Tanaka, Kazuo Nakanishi, Yoshihisa Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Keiichiro Nishida, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 63 ( 6 ) 373 - 377 2009年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Scoliosis is a common clinical manifestation of Rett syndrome, a neurodevelopmental disorder that almost exclusively affects females. The spinal curve in patients with Rett syndrome is typically a long C curve of a neuromuscular type. As the onset of the scoliosis is very early and shows rapid progression, early surgical intervention has been recommended to prevent a life-threatening collapsing spine syndrome. However, there are high perioperative risks in Rett syndrome patients who undergo spinal surgery, such as neurological compromise and respiratory dysfunction due to rigrid spinal curve. We herein report the surgical result of treating severe rapid progressive thoracic scoliosis in a 16-year-old girl with Rett syndrome. Posterior segmental pedicle screw fixation was performed from T1 to L3 using a computer-assisted technique. Post-operative radiography demonstrated a good correction of the curve in both the sagittal and coronal alignment. There were no postoperative complications such as neurological compromise. The patient had maintained satisfactory spinal balance as of the 3-year follow-up examination.

DOI： 10.18926/AMO/31823

A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification

Kanae Kumagishi, Keiichiro Nishida, Tomoichiro Yamaai, Ryusuke Momota, Shigeru Miyaki, Satoshi Hirohata, Ichiro Naito, Hiroshi Asahara, Yoshifumi Ninomiya, Aiji Ohtsuka

ARCHIVES OF HISTOLOGY AND CYTOLOGY 72 ( 3 ) 175 - 185 2009年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：INT SOC HISTOLOGY & CYTOLOGY

A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) is known to influence aggrecan degradation in endochondral ossification, but its role has not been well understood. In the present study, in vitro gene expression of ADAMTS9 was investigated by RT-PCR in ATDC5 cells in which experimentally chondrogenic differentiation had been induced. We also investigated the protein localization and gene expression pattern of ADAMTS9 in the tibia growth plate cartilage of male mice in a day 1 neonate, 7-week-old young adult, and a 12-week-old adult by immunohistochemistry and in situ hybridization and compared the results with the expression of proliferating cell nuclear antigen (PCNA) and type X collagen for the identification of proliferative and hypertrophic chondrocyte phenotypes, respectively. We found the gene expression of ADAMTS9 by ATDC5 cells as a dual mode, both before the expression of type X collagen and after hypertrophic differentiation. The immunoreactivity of ADAMTS9 was observed in chondrocytes of proliferative and hypertrophic zones in the growth plate. The population of ADAMTS9 positive cells decreased with age. The results of the present study suggest that ADAMTS9 might have a role in aggrecan cleavage around the chondrocytes to allow chondrocyte proliferation and hypertrophy.

DOI： 10.1679/aohc.72.175

Mechanical stretch stimulates integrin αVβ3-mediated collagen expression in human anterior cruciate ligament cells

Tetsunaga T, Furumatsu T, Abe N, Nishida K, Naruse K, Ozaki T

Journal of Biomechanics 42 ( 13 ) 2097 - 2103 2009年9月

Optical imaging of mouse articular cartilage using the glycosaminoglycans binding property of fluorescent-labeled octaarginine

K. Inagawa, T. Oohashi, K. Nishida, J. Minaguchi, T. Tsubakishita, K. O. Yaykasli, A. Ohtsuka, T. Ozaki, T. Moriguchi, Y. Ninomiya

OSTEOARTHRITIS AND CARTILAGE 17 ( 9 ) 1209 - 1218 2009年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：W B SAUNDERS CO LTD

Objective: The aim of the current study was to examine the cartilage-specific binding property of polyarginine peptides (R4, 8, 12, and 16) and specifically to test octaarginine peptides for the optical imaging of articular cartilage in experimentally induced arthritis in mice.
Methods: Four rhodamine-labeled polyarginine peptides each with a different-length arginine chain (R4, 8, 12, or 16) were injected into the knee joints of C57BL/6J mice (n = 20). The joints were excised 1 h later and the fluorescent signal intensity in cartilage cryosections was compared for the four peptides. To examine the substrate of R8 in cartilage, femoral condyles obtained from another set of mice were treated with chondroitinase ABC (Ch'ase ABC), keratanase or heparitinase then immersed in R8-rhodamine. Fluorescent signals were examined by fluorescent microscopy. Next, R8-rhodamine was injected into the right knee joints of three control and three collagen antibody-induced arthritis (CAIA) mice, and fluorescent intensity in normal and degenerative cartilage was semi-quantitatively analysed on the histological sections using image software. Finally, femoral condyles from normal mice (n = 2) and CAIA mice (n = 2) were immersed in R8-rhodamine and calcein, then imaged using optical projection tomography (OPT).
Results: Fluorescent signals were specifically detected in the cartilage pericellular matrix from the surface to the tide mark but were completely absent in the calcified layer or bone marrow. The number of arginine residues significantly influenced peptide accumulation in articular cartilage, with R8 accumulating the most. The fluorescent signal in the femoral condylar cartilage diminished when it was treated with Ch'ase ABC. R8 accumulation was significantly decreased in the degenerative cartilage of CAIA mice, and this was demonstrated both histologically and in three-dimensional (3D)-reconstruction image by OPT.
Conclusion: R8 may be a useful new experimental probe for optical imaging of normal and arthritic articular cartilage. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.joca.2009.03.010

【整形外科関節リウマチ保存治療の実際】RA診断・治療におけるMRIの有用性

中原龍一, 西田圭一郎

Orthopaedics 22 ( 9 ) 31 - 38 2009年8月

記述言語：日本語出版者・発行元：(株)全日本病院出版会

関節リウマチ(RA)に対する治療ガイドラインが策定され、生物学的製剤の登場やメトトレキサートの積極的使用により、早期診断、薬効評価における画像診断の重要性が大きくなりつつある。MRI画像によって得られるRAに特徴的な所見としては、滑膜炎、骨びらん、骨髄浮腫、腱鞘滑膜炎などがあり、補助診断としてRAを早期に診断し、予後不良因子などをもとに治療法を決定し、寛解・薬剤中止を目指すためのツールとしてのエビデンスが蓄積されつつある。早期診断においてはfalse positiveの除外を含めた正しい評価方法を知ることが重要であり、薬効判定においては滑膜体積や最大造影速度などを用いた定量的判定が求められている。(著者抄録)

マウス成長軟骨におけるADAMTS-9発現とその役割について

熊岸加苗, 西田圭一郎, 百田龍輔, 山合友一朗, 廣畑聡, Kadir Demircan, 内藤一郎, 二宮善文, 大塚愛二

解剖学雑誌 84 ( Suppl. ) 139 - 139 2009年3月

Target-tropic accumulation of SLX-liposome in arthritis mouse 査読

Minaguchi JA, Minematsu H, Oohashi T, Otani T, Inagawa K, Oie K, Nishida K, Ohtsuka A, Ninomiya Y, Igarashi K

Matrix Biology 27 43 - 43 2008年12月

The expression of microRNA424 in rheumatoid arthritis

Yoshitaka, Teruhito, Nakasa, Tomoyuki, Inoue, Atsushi, Okubo, Atsuko, Takemoto, Fuko, Miyaki, Shigeru, Nishida, Keiichiro, Ochi, MitStio, Ozaki, Toshifumi, Sumida, Takayuki, Asahara, Hiroshi

ARTHRITIS AND RHEUMATISM 58 ( 9::Suppl. S ) 0 - 0 2008年9月

Disease-specific screening for deep venous thrombosis and pulmonary thromboembolism using plasma D-dimer values after total knee arthroplasty

Teruhito Yoshitaka, Nobuhiro Abe, Hiroshi Minagawa, Hirokazu Date, Yoshimasa Sakoma, Keiichiro Nishida, Toshifumi Ozaki

MODERN RHEUMATOLOGY 18 ( 4 ) 359 - 365 2008年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

We prospectively evaluated the disease-specific features of the early postoperative plasma D-dimer value and the relationship with deep venous thrombosis and/or pulmonary thromboembolism (DVT/PE) in 95 patients following total knee arthroplasty. Patients in whom DVT/PE was highly suspected were diagnosed by high-resolution multi-detector row computed tomography scanning (MDCT). Forty-nine knees in 46 patients with rheumatoid arthritis (RA, 24 knees) or osteoarthritis (OA, 25 knees) were finally recruited. DVT/PE was detected in 28 (57.1%) of the 49 cases examined by diagnostic MDCT: 12 (50.0%) of the 24 cases of RA, and 16 (64.0%) of the 25 cases of OA. Of these, PE was found in 11 cases (39.2%), but none of them showed clinical symptomatic signs of dyspnea or chest pain. In both RA and OA cases, there were statistically significant differences in the D-dimer value on postoperative day 3 (P = 0.027) and after day 28 (P = 0.037) between the groups with and without DVT/PE. In OA cases, there were significant differences between the two groups on postoperative days 1 (P = 0.034), 3 (P = 0.020), 5 (P = 0.005), and 7 (P = 0.045), respectively. At the baseline, perioperative D-dimer levels in the RA group without DVT/PE were higher than in the OA group. However, multivariate logistic regression analysis showed that RA was not a significant risk factor of DVT/PE in comparison with OA. In conclusion, individual evaluation of the D-dimer level between RA and OA should provide a more precise predictive indicator of early postoperative DVT/PE.

DOI： 10.1007/s10165-008-0068-6

Intra-articular injection of interleukin-4 decreases nitric oxide production by chondrocytes and ameliorates subsequent destruction of cartilage in instability-induced osteoarthritis in rat knee joints

M. Yorimitsu, K. Nishida, A. Shimizu, H. Doi, S. Miyazawa, T. Komiyama, Y. Nasu, A. Yoshida, S. Watanabe, T. Ozaki

OSTEOARTHRITIS AND CARTILAGE 16 ( 7 ) 764 - 771 2008年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Objective: To investigate the in vitro and in vivo effects of interleukin (IL)-4 on mechanical stress-induced nitric oxide (NO) expression by chondrocytes, and destruction of cartilage and NO production in an instability-induced osteoarthritis (OA) model in rat knee joints, respectively.
Materials and methods: Cyclic tensile stress (CTS; 0.5 Hz and 7% elongation) was applied to cultured normal rat chondrocytes with or without pre-incubation with recombinant rat IL-4 (rrIL-4). Inducible NO synthase (iNOS) mRNA expression and NO production were examined with real-time polymerase chain reaction and the Griess reaction, respectively. OA was induced in rat knee joints by transection of the anterior cruciate and medial collateral ligaments and resection of the medial meniscus. rrIL-4 (10, 50, and 100 ng/joint/day) was injected intra-articularly, and knee joint samples were collected 2, 4, and 6 weeks after surgery. Cartilage destruction was evaluated by the modified Mankin score and Osteoarthritis Research Society International scoring system on paraffin-embedded sections stained with safranin O. Cleavage of aggrecan and NO production were examined by immunohistochemistry for aggrecan neoepitope (NITEGE) and of nitrotyrosine (NT), respectively.
Results: rrIL-4 down-regulated CTS-induced iNOS mRNA expression and NO production by chondrocytes. The intra-articular injection of rrIL-4 gave rise to a limited, but significant amelioration of cartilage destruction, prevention of loss of aggrecan, and decrease in the number of NT-positive chondrocytes, an effect that was not dose-dependent.
Conclusion: The present study suggests that IL-4 may exert chondroprotective properties against mechanical stress-induced cartilage destruction, at least in part, by inhibiting NO production by chondrocytes. (C) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.joca.2007.11.006

Novel magnetic resonance imaging evaluation for valgus instability of the knee caused by medial collateral ligament injury

Hisanori Ikuma, Nobuhiro Abe, Youichiro Uchida, Takayuki Furumatsu, Kazuo Fujiwara, Keiichiro Nishida, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 62 ( 3 ) 185 - 191 2008年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Instability of the knee after the medial collateral ligament (MCL) injury is usually assessed with the manual valgus stress test, even though, in recent years, it has become possible to apply magnetic resonance imaging (MRI) to the assessment of the damage of the ligament. The valgus instability of 24 patients (12 isolated injuries and 12 multiple ligament injuries) who suffered MCL injury between 1993 and 1998 was evaluated with the Hughston and Eilers classification, which involves radiographic assessment under manual valgus stress to the injured knees. We developed a novel system for classifying the degree of injury to the MCL by calculating the percentage of injured area based on MRI and investigated the relationship between this novel MRI classification and the magnitude of valgus instability by the Hughston and Eilers classification. There was a significant correlation between the 2 classifications (p = 0.0006). On the other hand, the results using other MRI based classification systems, such as the Mink and Deutsch classificaiton and the Petermann classification, were not correlated with the findings by the Hughston and Eilers classification in these cases (p > 0.05). Since MRI is capable of assessing the injured ligament in clinical practice, this novel classification system would be useful for evaluating the stability of the knee and choosing an appropriate treatment following MCL injury.

DOI： 10.18926/AMO/30974

Expression of MicroRNA-146 in rheumatoid arthritis synovial tissue

Tomoyuki Nakasa, Shigeru Miyaki, Atsuko Okubo, Megumi Hashimoto, Keiichiro Nishida, Mitsuo Ochi, Hiroshi Asahara

ARTHRITIS AND RHEUMATISM 58 ( 5 ) 1284 - 1292 2008年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Objective. Several microRNA, which are similar to 22-nucleotide noncoding RNAs, exhibit tissue-specific or developmental stage-specific expression patterns and are associated with human diseases. The objective of this study was to identify the expression pattern of microRNA-146 (miR-146) in synovial tissue from patients with rheumatoid arthritis (RA).
Methods. The expression of miR-146 in synovial tissue from 5 patients with RA, 5 patients with osteoarthritis (OA), and 1 normal subject was analyzed by quantitative reverse transcription-polymerase chain reaction (RT-PCR) and by in situ hybridization and immunohistochemistry of tissue sections. Induction of miR-146 following stimulation with tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) of cultures of human rheumatoid arthritis synovial fibroblasts (RASFs) was examined by quantitative PCR and RT-PCR.
Results. Mature miR-146a and primary miR146a/b were highly expressed in RA synovial tissue, which also expressed TNF alpha, but the 2 microRNA were less highly expressed in OA and normal synovial tissue. In situ hybridization showed primary miR-146a expression in cells of the superficial and sublining layers in synovial tissue from RA patients. Cells positive for miR-146a were primarily CD68+ macrophages, but included several CD3+ T cell subsets and CD79a+ B cells. Expression of miR-146a/b was markedly upregulated in RASFs after stimulation with TNF alpha and IL-1 beta.
Conclusion. This study shows that miR-146 is expressed in RA synovial tissue and that its expression is induced by stimulation with TNF alpha and IL-1 beta. Further studies are required to elucidate the function of miR-146 in these tissues.

DOI： 10.1002/art.23429

Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes

Hideyuki Doi, Keiichiro Nishida, Masanori Yorimitsu, Takamitsu Komiyama, Yasutaka Kadota, Tomonori Tetsunaga, Aki Yoshida, Satoshi Kubota, Masaharu Takigawa, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 62 ( 2 ) 119 - 126 2008年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Mechanical stress plays a key role in the pathogenesis of cartilage destruction seen in osteoarthritis (OA). We investigated the effect of cyclic tensile stress (CTS) on the anabolic and catabolic gene expression of rat cultured normal chondrocytes using the Flexercell strain unit. The effects of interleukin (IL)-4, a chondroprotective cytokine, on the changes in gene expression induced by CTS were also investigated. CTS (7% elongation at 0.5 Hz) for 24 h did not affect the expression of aggrecan and type 11 collagen, whereas CTS significantly upregulated matrix metalloproteinase (MMP)-13 and cathepsin B mRNA expression by chondrocytes. IL-1 beta expression was also significantly upregulated by CTS up to 12 h. The upregulation of MMP-13 was observed at 3 h, which was earlier than that of IL-1 beta. Furthermore, pre-treatment with IL-4 (10 ng/ml) suppressed both MMP-13 and cathepsin B induction by mechanical stress, as well as CTS-induced IL-1 beta expression. Our results suggest that IL-4 might have a therapeutic value in the treatment of OA by downregulation of mechanical stress-induced MMP-13 and cathepsin B expression by chondrocytes.

DOI： 10.18926/AMO/30956

Application of laminar screws to posterior fusion of cervical spine

Kazuo Nakanishi, Masato Tanaka, Yoshihisa Sugimoto, Haruo Misawa, Tomoyuki Takigawa, Kazuo Fujiwara, Keiichiro Nishida, Toshifumi Ozaki

SPINE 33 ( 6 ) 620 - 623 2008年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Study Design. Morphometric analysis.
Objective. For safe and solid fixation, it is necessary to measure the diameter of the vertebral arch to ascertain whether or not screws can be used and if so, the appropriate size of screws to be used.
Summary of Background Data. Cervical pedicle screws are the most biomechanically stable screws. However, their use carries a high risk of neurovascular complications during screw insertion. In 2004, a new method to avoid such vertebral artery injuries was reported by insertion of screws with crosswise to the lamina of C2. For safe and solid fixation, it is necessary to measure the diameter of the vertebral arch to ascertain whether or not screws can be used and if so, the appropriate size of screws to be used. There is no report of the diameter of the vertebral arch by a navigation system.
Methods. Morphometric analysis was performed on 42 patients who had undergone a CT scan of the cervical spine for either surgery or diagnostic purposes. To examine the possibilities to insert laminar screws, the diameter of the vertebral arch was measured using a navigation system.
Results. The diameter of the vertebral arch in C2 was the largest in the cervical spine, individual differences ranging between 0.8 and 8.4 mm. In C2, insertion of screws with a diameter of 3 mm was possible in 80% of males and 63% of females. As for screws with a diameter of 4 mm, insertion was possible in 50% of the males and 24% of the females in C2. In C2, gender had a significant effect, but left-right differences and height did not.
Conclusion. Laminar screws are useful as they can prevent vascular injuries, but a preoperative evaluation is necessary.

DOI： 10.1097/BRS.0b013e318166aa76

Inhibition of histone deacetylase down-regulates the expression of hypoxia-induced vascular endothelial growth factor by rheumatoid synovial fibroblasts

H. Manabe, Y. Nasu, T. Komiyama, T. Furumatsu, A. Kitamura, S. Miyazawa, Y. Ninomiya, T. Ozaki, H. Asahara, K. Nishida

INFLAMMATION RESEARCH 57 ( 1 ) 4 - 10 2008年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BIRKHAUSER VERLAG AG

Objective: To investigate the effect of FK228 on the in vitro expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) by rheumatoid arthritis synovial fibroblasts (RASFs), and on the in vivo expression of VEGF and angiogenesis in the synovial tissue of mice with collagen-antibody-induced arthritis (CAIA).
Methods: RASFs were stimulated with IL-1 beta and TNF alpha and then incubated under hypoxia (1 % O-2) with various concentrations of FK228. The effects of FK228 on the expression of HIF-1 alpha and VEGF mRNA were examined by quantitative real-time PCR. Changes in HIF-1 alpha protein expression and the secretion of VEGF protein into the culture medium were examined by Western blot analysis and ELISA, respectively. Immunohistochemical analysis was carried out to investigate the expression and distribution of VEGF in synovial tissues of CAIA mice.
Results: The cytokine-stimulated expression of HIF-1 alpha and VEGF mRNA was inhibited by FK228 in a dose-dependent manner. FK228 also reduced the expression of HIF-1 alpha and VEGF protein. Intravenous administration of FK228 (2.5 mg/kg) suppressed VEGF expression, and also blocked angiogenesis in the synovial tissue of CAIA.
Conclusion: FK228 may exhibit a therapeutic effect on RA by inhibition of angiogenesis through down-regulation of angiogenesis related factors, HIF-1 alpha and VEGF.

DOI： 10.1007/s00011-007-7036-z

Isolation of a mRNA preferentially expressed in synoviocytes from rheumatoid arthritis that is identical with lumican, which encodes a collagen binding Extracellular Matrix Protein 査読

Hiroki Mori, Keiichiro Nishida, Toshifumi Ozaki, Hajime Inoue, Tohru Nakanishi

Journal of Hard Tissue Biology 17 ( 3 ) 125 - 130 2008年

記述言語：英語掲載種別：研究論文（学術雑誌）

Rheumatoid arthritis (RA) is a complex disease including autoimmune disorder and resulting in inflammation. It also shows progressive proliferation of synoviocytes, and these synoviocytes destroys articular structure. In order to understand the mechanism of this abnormal proliferation of RA-originated synoviocytes in molecular level, we analyzed the gene expression profiles by using DNA chips that contain more than 10,000 genes. Comparing the expression profiles of normal and RA-originated synoviocytes, we found several genes that are highly expressed in RA-originated synoviocytes than normal synoviocytes. Among these genes, we focused on one hypothetical protein, cDNA of which contains one reading frame in its DNA fragment, indicating that this fragment is a part of large mRNA structure. The expression of this gene in RA-originated synoviocytes is about three times higher than that in normal synoviocytes by DNA chip analysis. After cDNA cloning of this mRNA, we found that the gene is identical with lumican, which encodes a collagen binding, extracellular matrix protein. This mRNA was widely distributed in many tissues but its alternatively spliced forms are differently expressed in various tissues. ©2008 The Hard Tissue Biology Network Association Printed in Japan, All rights reserved.

DOI： 10.2485/jhtb.17.125

Chondrosarcoma and Peroxisome Proliferator-Activated Receptor

K. Nishida, T. Kunisada, Z. N. Shen, Y. Kadota, K. Hashizume, T. Ozaki

PPAR RESEARCH 2008 1 - 7 2008年

記述言語：英語出版者・発行元：HINDAWI PUBLISHING CORPORATION

Induction of differentiation and apoptosis in cancer cells by ligands of PPAR gamma is a novel therapeutic approach to malignant tumors. Chondrosarcoma (malignant cartilage tumor) and OUMS-27 cells (cell line established from grade III human chondrosarcoma) express PPAR gamma. PPAR gamma ligands inhibited cell proliferation in a dose-dependent manner, and induced apoptosis of OUMS-27. The higher-grade chondrosarcoma expressed a higher amount of antiapoptotic Bcl-xL in vivo. The treatment of OUMS-27 by 15d-PGJ(2), the most potent endogenous ligand for PPAR gamma, downregulated expression of Bcl-xL and induced transient upregulation of proapoptotic Bax, which could accelerate cytochrome c release from mitochondria to the cytosol, followed by induction of caspase-dependent apoptosis. 15d-PGJ(2) induced the expression of CDK inhibitor p21 protein in human chondrosarcoma cells, which appears to be involved in the mechanism of inhibition of cell proliferation. These findings suggest that targeted therapy with PPAR gamma ligands could be a novel strategy against chondrosarcoma. Copyright (C) 2008 K. Nishida et al.

DOI： 10.1155/2008/250568

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

Nasu Y, Nishida K, Miyazawa S, Komiyama T, Kadota Y, Abe N, Yoshida A, Hirohata S, Ohtsuka A, Ozaki T

Osteoarthritis and Cartilage 16 ( 6 ) 723 - 732 2008年

The distribution of type IV collagen α chains in basement membranes of human epidermis and skin appendages

Hasegawa H, Naito I, Nakano K, Momota R, Nishida K, Taguchi T, Sado Y, Ninomiya Y, Ohtsuka A

Arch Histol Cytol 70 ( 4 ) 255 - 265 2007年11月

New approach for assessing vascular distribution within bone tumors using dynamic contrast-enhanced MRI

Yukio Kawakami, Toshiyuki Kunisada, Shinsuke Sugihara, Atsushi Ono, Keiichiro Nishida, Nobuhiro Abe, Akira Kawai, Kazuo Fujiwara, Yuki Morimoto, Toshifumi Ozaki

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 133 ( 10 ) 697 - 703 2007年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Purpose To differentiate benign from malignant bone tumors by analyzing the vascular distribution within bone tumors with dynamic contrast-enhanced MRI.
Methods We studied dynamic contrast-enhanced MRI for 49 bone tumors (22 malignant and 27 benign tumors). Seven small regions of interest (ROI) were set inside the largest portion of each tumor. Four ROI were placed evenly on the periphery and three ROI were placed evenly on the line of the longest breadth within the tumor. The slope of the curve (%Slope) was calculated on the time-intensity curves of the whole tumor and of each ROI. The variance values for the %Slope of the ROI were calculated to assess the dispersion of the intensity change at each ROI within the tumor.
Results Mean value of the %Slopes of whole tumor regions for malignant bone tumors (70.4 +/- 60.3%) was significantly higher than that for benign bone tumors (37.6 +/- 52.9%) (P = 0.015), although giant cell tumor (GCT), a locally aggressive tumor, had a relatively higher %Slope. Mean value of the variance of %Slopes for malignant bone tumors (3485.9 +/- 5942.5) was significantly higher than that for all benign tumors (470.4 +/- 583.9) (P = 0.012), indicating that the %Slope values of seven ROI within malignant bone tumors varied more widely compared with the ROI inside benign bone tumors. GCT also demonstrated a lower value.
Conclusion Our method of analyzing the signal intensity change at seven separate regions that evaluates the vascular distribution within a tumor could be a useful tool for differentiating between benign and malignant bone tumors.

DOI： 10.1007/s00432-006-0190-9

A novel dominant-negative mutation in Gdf5 generated by ENU mutagenesis impairs joint formation and causes osteoarthritis in mice

Hiroshi Masuya, Keiichiro Nishida, Tatsuya Furuichi, Hideaki Toki, Gen Nishimura, Hidehiko Kawabata, Haruka Yokoyama, Aki Yoshida, Sayaka Tominaga, Junko Nagano, Aya Shimizu, Shigeharu Wakana, Yoichi Gondo, Tetsuo Noda, Toshihiko Shiroishi, Shiro Ikegawa

HUMAN MOLECULAR GENETICS 16 ( 19 ) 2366 - 2375 2007年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OXFORD UNIV PRESS

Growth and differentiation factor 5 (GDF5) has been implicated in chondrogenesis and joint formation, and an association of GDF5 and osteoarthritis (OA) has been reported recently. However, the in vivo function of GDF5 remains mostly unclarified. Although various human GDF5 mutations and their phenotypic consequences have been described, only loss-of-function mutations that cause brachypodism (shortening and joint ankylosis of the digits) have been reported in mice. Here, we report a new Gdf5 allele derived from a large-scale N-ethyl-N-nitrosourea mutagenesis screen. This allele carries an amino acid substitution (W408R) in a highly conserved region of the active signaling domain of the GDF5 protein. The mutation is semi-dominant, showing brachypodism and ankylosis in heterozygotes and much more severe brachypodism, ankylosis of the knee joint and malformation with early-onset OA of the elbow joint in homozygotes. The mutant GDF5 protein is secreted and dimerizes normally, but inhibits the function of the wild-type GDF5 protein in a dominant-negative fashion. This study further highlights a critical role of GDF5 in joint formation and the development of OA, and this mouse should serve as a good model for OA.

DOI： 10.1093/hmg/ddm195

Comparative biomechanical analysis of an improved novel pedicle screw with sheath and bone cement

Tomoyuki Takigawa, Masato Tanaka, Hitoshi Konishi, Hisanori Ikuma, Haruo Misawa, Yoshihisa Sugimoto, Kazuo Nakanishi, Koichi Kuramoto, Keiichiro Nishida, Toshifumi Ozaki

JOURNAL OF SPINAL DISORDERS & TECHNIQUES 20 ( 6 ) 462 - 467 2007年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

Study Design: A human cadaveric biomechanical study of fixation strength of an improved novel pedicle screw (NPS) with cement and a conventional screw.
Objective: To clarify whether the NPS has adequate fixation strength without leakage in vertebrae with low bone quality.
Summary of Background Data: The fixation strength of pedicle screws decreases in frail spines of elderly osteoporotic patients. Augmentation of screw fixation with bone cement must be balanced against increased difficulty of screw removal and risk of cement leakage. We developed the NPS consisting of an internal screw and an outer sheath to mitigate the disadvantages of cement augmentation.
Methods: The T12 and L1 vertebrae obtained from 18 formalin preserved cadavers (11 males and 7 females; mean age, 82.7y) were used. The mean bone mineral density was 0.39 +/- 0.14 g/cm(2). The NPS was inserted into one pedicle of each vertebra and the control screw, a Compact CD2 screw, was inserted into the contralateral pedicle. Both screws were 6 mm in diameter and 40 mm in length. Pull-out tests were performed at a crosshead speed of 10 mm/min. Cyclic loading tests were performed with a maximum 250 N load at 2 Hz until 30,000 cycles.
Results: Cement leakage did not occur in any of the specimens tested. The mean maximum force at pull-out was 760 +/- 344 N for the NPS and 346 172 N for the control screw (P < 0.01). Loosening of 50% of the screws was observed after 17,000 cycles of the NPS and after 30 cycles of the control screw. The hazard ratio of loosening was 19.6 (95% confidence interval 19.3-19.9) (P < 0.001).
Conclusions: The NPS showed a significantly higher mechanical strength than the control screw in both pull-out tests and cyclic loading test than the control screw in both pull-out tests and cyclic loading test. The NPS showed more than adequate strength without cement leakage.

DOI： 10.1097/BSD.0b013e318030d2d6

IV型コラーゲンα鎖特異抗体を用いた血管基底膜の三次元観察

The association of C-reactive protein with an oxidative metabolite of LDL and its implication in atherosclerosis

Masako Tabuchi, Katsumi Inoue, Hitomi Usui-Kataoka, Kazuko Kobayashi, Misako Teramoto, Koji Takasugi, Kenichi Shikata, Masahiro Yamamura, Kenji Ando, Keiichiro Nishida, Junko Kasahara, Noriaki Kume, Luis R. Lopez, Kazuaki Mitsudo, Masakiyo Nobuyoshi, Tatsuji Yasuda, Toru Kita, Hirofumi Makino, Eiji Matsuura

JOURNAL OF LIPID RESEARCH 48 ( 4 ) 768 - 781 2007年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

C-reactive protein (CRP) is one of the strongest independent predictors of cardiovascular disease. We have previously reported that oxidized LDL (oxLDL) interacts with beta 2-glycoprotein I (beta 2GPI), implicating oxLDL/P2GPI complexes as putative autoantigens in autoimmune-mediated atherosclerotic vascular disease. In this study, we investigated the interaction of CRP with oxLDL/beta 2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus (DM). CRP/oxLDL/R2GPI complexes were predominantly found in sera of DM patients with atherosclerosis. In contrast, noncomplexed CRP isoforms were present in sera of patients with acute/chronic inflammation, i.e., various pyrogenic diseases, rheumatoid arthritis (RA), and DM. Immunohistochemistry staining colocalized CRP and beta 2GPI together with oxLDL in carotid artery plaques but not in synovial tissue from RA patients, strongly suggesting that complex formation occurs during the development of adierosclerosis. Serum levels of CRP correlated with soluble forms of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1, and oxLDL/beta 2GPI complexes correlated with total cholesterol and hemoglobin Al c. Thus, the generation of CRP/oxLDL/beta 2GPI complexes seems to be associated with arterial inflammation, hyperglycemia, and hypercholesterolemia. CRP/oxLDL/R2GPI complexes can be distinguished from pyrogenic noncomplexed CRP isoforms and may represent a more specific and predictive marker for atherosclerosis.

DOI： 10.1194/jlr.M600414-JLR200

マウス成長軟骨におけるADAMTS-9発現の検討

熊岸加苗, 西田圭一郎, 百田龍輔, 山合友一朗, 広畑聡, Demircan Kadir, 内藤一郎, 二宮善文, 大塚愛二

解剖学雑誌 82 ( Suppl. ) 150 - 150 2007年3月

A new Gdf5 allele with fusion of knee joint 査読

Masuya Hiroshi, Furuichi Tatsuya, Nishida Keiichirou, Nagano Junko, Yokoyama Haruka, Miura Ikuo, Wakana Shigeharu, Ikegawa Shirou, Shiroishi Toshihiko

GENES & GENETIC SYSTEMS 81 ( 6 ) 447 2006年12月

森本尊雅, 内藤一郎, 田口勇仁, 芳原成美, 長谷川治子, 中野和代, 佐渡義一, 西田圭一郎, 二宮善文, 大塚愛二

解剖学雑誌 81 ( 3 ) 96 - 96 2006年9月

Decreased levels of insulin-like growth factor-1 and vascular endothelial growth factor relevant to the ossification disturbance in femoral heads spontaneous hypertensive rats

Takamitsu Komiyama, Keiichiro Nishida, Masanori Yorimitsu, Hideyuki Doi, Shinichi Miyazawa, Ai Kitamura, Aki Yoshida, Yoshihisa Nasu, Nobuhiro Abe, Toshifumi Ozaki

ACTA MEDICA OKAYAMA 60 ( 3 ) 141 - 148 2006年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Ossification disturbance in femoral head reportedly is seen in the Spontaneously Hypertensive rats (SHR) between ages of 10 and 20 weeks. We investigated serum and tissue levels of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VIEGF) in SHR relevant to the ossification disturbance and osteonecrosis of the femoral head. Serum levels of IGF-1 and VEGF were significantly lower in SHR than in Wistar Kyoto rats (WKY) at weeks 5, 10, 15 and 20 (P < 0.005). The incidence of histological ossification disturbance of the femoral head was higher in SHR (59%) than in WKY (40%) at week 20. Lower serum and local levels of VEGF in SHR appeared to be related to the incomplete ossification of the femoral heads. Immunohistochemical study showed significantly lower numbers of IGF-1 and VEGF positive chondrocytes in the femoral epiphyseal cartilage of SHR than in those of WKY at weeks 10, 15 and 20. Our results suggest that local and/or systemic levels of IGF-1 and VEGF between ages of 5 and 20 weeks might play roles in the pathogenesis of ossification disturbance of the femoral head in SHR.

DOI： 10.18926/AMO/30749

血管基底膜IV型コラーゲンの免疫組織学的解析共焦点レーザー顕微鏡を用いた三次元観察

森本尊雅, 内藤一郎, 百田龍輔, 芳原成美, 長谷川治子, 田口勇仁, 西田圭一郎, 佐渡義一, 二宮善文, 大塚愛二

解剖学雑誌 81 ( Suppl. ) 155 - 155 2006年3月

In situ preparation of colloidal iron by microwave irradiation for transmission electron microscopy

S Nakatani, Naito, I, R Momota, N Hinenoya, K Horiuchi, K Nishida, A Ohtsuka

ACTA MEDICA OKAYAMA 60 ( 1 ) 59 - 64 2006年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

We attempted to prepare colloidal iron within tissues by means of microwave irradiation. Mouse tissue blocks were fixed with a mixture of paraformaldehyde and ferric chloride in a cacodylate buffer, immersed in a cacodylate buffered ferric chloride solution, and irradiated in a microwave processor. Colloidal iron was prepared within tissues or cells, and was observed in the form of electron dense fine granules (1-2 nm in diameter) by transmission electron microscopy. Collagen fibrils in the connective tissue showed colloidal iron deposition at regular periodical intervals. Cells in the splenic tissue showed that fine colloidal granules were deposited on the ribosomes but not on the nuclear chromatin. This finding suggests that ferric ions could not diffuse into the nucleus, which was surrounded by the nuclear envelope. The podocyte processes of the renal glomerulus were stained diffusedly. Though this microwave in situ colloidal iron preparation method has some limitations, it is convenient for use in biomedical specimen preparation in transmission electron microscopy.

Novel transdermal photodynamic therapy using ATX-S10·Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice

Miyazawa, S., Nishida, K., Komiyama, T., Nakae, Y., Takeda, K., Yorimitsu, M., Kitamura, A., Kunisada, T., Ohtsuka, A., Inoue, H.

Rheumatology International 26 ( 8 ) 2006年

Expression of WISP-1 (ccn4), WISP-2 (ccn5) and WISP-3 (ccn6) in rheumatoid arthritic synovium evaluated by DNA microarrays

Mori H, Nishida K, Ozaki T, Inoue H, Setsu K, Tsujigiwa H, Nagatsuka H, Gunduz M, Nakanishi T

J Hard Tissue Biol 15 ( 3 ) 89 - 95 2006年

記述言語：英語出版者・発行元：硬組織再生生物学会

Rheumatoid disease (RA) is one of the complex diseases that showed multiple progression stages. At first inflammatory response is occurred by self antibodies, and then the proliferation of synoviocytes is abnormally promoted. These synoviocytes invade into articular structures and finally articular cartilage is destroyed. In order to analyze growth-promoting factors in synovial cells from articular tissues of RA, we performed DNA microarray analysis and compared the expression patterns of their mRNA to that of synoviocytes from osteoarthritis (OA). The results showed that the expression of many genes was up-regulated in RA synoviocytes comparing with OA synoviocytes. Among these genes, RT-PCR analysis revealed that Wnt-1-induced secreted protein 2 (WISP-2, CCN5) and protein 3 (WISP-3, CCN6) which are belong to the novel gene family, CCN, were highly up-regulated in RA synoviocytes. In addition, one truncated isoform of WISP-3 which may be related to the ongoing of some type of RA, was detected in RA synoviocytes. Furthermore, immunohistochemical analysis showed that the products of both CCN genes were highly distributed in active synoviocytes of articular tissues of RA. These results indicate that both CCN genes and their products play some roles in the progression of RA.

DOI： 10.2485/jhtb.15.89

その他リンク： http://search.jamas.or.jp/link/ui/2007191489

Accuracy of a portable electroneurometer for measuring distal motor latency

H Tanaka, H Hashizume, C McCown, M Senda, K Nishida, H Inoue

JOURNAL OF ORTHOPAEDIC SCIENCE 10 ( 5 ) 445 - 450 2005年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER TOKYO

Background A facile electromyographic test in the outpatient clinic is needed to evaluate the outcome of screening for carpal tunnel syndrome. The purpose of the current prospective study was to compare the accuracy of Nervepace digital electroneurometer (Nervepace) and Dantec Neuromatic 2000M (Dantec) measurements of a wide range of distal motor latency (DML) of the median nerve.
Methods. The DML values for 112 of 126 median nerves examined with Nervepace and conventional electromyography, Dantec were statistically analyzed in this prospective study. The 30 hands of 15 clinically healthy adults 20-24 years old served as the reference group. Sixty consecutive patients (96 hands) with idiopathic carpal tunnel syndrome provided a wider range of DML values. All of the patients had standard clinical tests and standard motor (Dantec and Nervepace) and sensory (Dantec) electrodiagostic tests before endoscopic carpal tunnel release.
Results. The DML was measurable in all 30 hands of the reference group, in all 96 hands of the patients by Dantec, but in only 82 hands (52 patients) by Nervepace. Nervepace and Dantec DML values of 6.0 ms or less had high correlation and agreement.
Conclusions. Correlation and agreement decreased significantly among values greater than 6.0ms.

DOI： 10.1007/s00776-005-0928-2

ADAMTS-9 is synergistically induced by interleukin-1 beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes

K Demircan, S Hirohata, K Nishida, OF Hatipoglu, T Oohashi, T Yonezawa, SS Apte, Y Ninomiya

ARTHRITIS AND RHEUMATISM 52 ( 5 ) 1451 - 1460 2005年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Objective. To compare induction of the aggrecanases (ADAMTS-1, ADAMTS-4, ADAMTS-5, ADAMTS-8, ADAMTS-9, and ADAMTS-15) by interleukin-1β (IL-1β) and tumor necrosis factor a (TNFα) in chondrocyte-like OUMS-27 cells and human chondrocytes, and to determine the mechanism of induction of the most responsive aggrecanase gene.
Methods. OUMS-27 cells were stimulated for different periods of time and with various concentrations of IL-1β and/or TNFa. Human chondrocytes obtained from osteoarthritic joints and human skin fibroblasts were also stimulated with IL-1β and/or TNFα. Total RNA was extracted, reverse transcribed, and analyzed by quantitative real-time polymerase chain reaction and Northern blotting. ADAMTS-9 protein was examined by Western blotting, and the role of the MAPK signaling pathway for ADAMTS9 induction in IL-1β-stimulated OUMS-27 cells was investigated.
Results. IL-1β increased messenger RNA (mRNA) levels of ADAMTS4, ADAMTS5, and ADAMTS9 but not ADAMTS1 and ADAMTS8. The fold increase for ADAMTS9 mRNA was greater than that for mRNA of the other aggrecanase genes. The increase of ADAMTS9 mRNA by IL-1β stimulation was greater in chondrocytes than in fibroblasts. The combination of IL-1β and TNFα had a synergistic effect, resulting in a considerable elevation in the level of ADAMTS9 mRNA. ADAMTS-9 protein was also induced in IL-1β-stimulated OUMS-27 cells. The MAPK inhibitors SB203580 and PD98059 decreased ADAMTS9 upregulation in OUMS-27 cells.
Conclusion. ADAMTS9 is an IL-1β- and TNFα-inducible gene that appears to be more responsive to these proinflammatory cytokines than are other aggrecanase genes. Furthermore, these cytokines had a synergistic effect on ADAMTS9. Together with the known ability of ADAMTS-9 to proteolytically degrade aggrecan and its potential to cleave other cartilage molecules, the data suggest that ADAMTS-9 may have a pathologic role in arthritis.

DOI： 10.1002/art.21010

Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats

S Arataki, K Tomizawa, A Moriwaki, K Nishida, M Matsushita, T Ozaki, T Kunisada, A Yoshida, H Inoue, H Matsui

JOURNAL OF NEUROTRAUMA 22 ( 3 ) 398 - 406 2005年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：MARY ANN LIEBERT INC

Traumatic spinal cord injury (SCI) results in widespread neuronal cell death. Recent studies have suggested that activated calpain mediates neuronal cell death in the central nervous system. We conducted a study to determine whether calpain mediates neuronal cell death in the motor neurons of the spinal cord after SCI, and whether postinjury administration of the calpain inhibitors N-acetyl-Leu-Leu-Met-CHO (ALLM) and calpain inhibitor III (CI III) (MDL28170) reduces the motor disturbances in rats with a model of SCI. Adult male Wistar rats were subjected to SCI by application of a 20-g weight impactor probe to the spinal cord at T12 for 20 min. The rats were divided into three groups according to whether they were injected intravenously with 0.05-2.5 mg/kg ALLM, 10 mg/kg CI III, or 0.1% DMSO as a control every 24 h for I week after SCI. Calpain was activated in the spinal cord at 8 h, 24 h, and 5 days after SCI, and administration of ALLM inhibited its activation. ALLM, as compared to the DMSO vehicle alone, also significantly reduced the number of motor neurons in spinal-cord lesions that were positively labeled at 24 h after SCI with the terminal deoxynucleotidyl transferase-uridine nucleotide end-labeling (TUNEL) technique. Additionally, both the inclined plane test and footprint analysis showed markedly better motor activity after 4 weeks in rats injected with ALLM or CI III than in rats given vehicle only. These results suggest that activation of calpain plays a critical role in the neuronal cell death that follows SCI, and that calpain inhibitors may have benefit in treating the motor disturbances that follow SCI.

DOI： 10.1089/neu.2005.22.398

Hoechst 33342は関節軟骨修復の長期研究において細胞標識物質として有用である

Suppression of chondrosarcoma cells by 15-deoxy-Delta (12,14)-prostaglandin J(2) is associated with altered expression of Bax/Bcl-xL and p21

ZN Shen, K Nishida, H Doi, T Oohashi, S Hirohata, T Ozaki, A Yoshida, Y Ninomiya, H Inoue

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 328 ( 2 ) 375 - 382 2005年3月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ACADEMIC PRESS INC ELSEVIER SCIENCE

We previously reported that 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), the most potent agonist for peroxisome proliferator-activated receptor gamma (PPARgamma), induces apoptosis of human chondrosarcoma cell line OUMS-27. The current study aimed to explore the mechanism of 15d-PGJ(2)-induced apoptosis and inhibition of cell proliferation in OUMS-27 cells. The preliminary results of cDNA microarray analysis showed the down-regulation of anti-apoptotic Bcl-xL and up-regulation of pro-apoptotic Bax in the process of 15d-PGJ2-induced apoptosis. These changes were further confirmed at mRNA and protein levels by RT-PCR and Western blot analysis, respectively. Among cyclin-dependent kinase inhibitors, p21 was induced and up-regulated by 15d-PGJ2, but p 16 and p27 were not changed, suggesting that the involvement of p21 in inhibition of cell proliferation. Activation of caspase-3 by 15d-PGJ2 was partly, but not completely, blocked by PPARgamma antagonist (GW9662) suggesting the 15d-PGJ2 exerted its effect by PPARgamma-dependent and -independent pathways. Interestingly, immunohistochemical study on human chondrosarcoma samples revealed that Bcl-xL is frequently expressed by tumor cells. The results of the current study suggest that the potential ability of 15d-PGJ2 in regulation of cell cycle and inhibition of Bcl-xL expression might be beneficial in the development of novel pharmacological agents for chondrosarcoma. (C) 2005 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2004.12.186

ヒト皮膚とその付属器の基底膜を構成するIV型コラーゲン分子のα鎖構成

長谷川治子, 内藤一郎, 中野和代, 米澤朋子, 西田圭一郎, 田口勇仁, 佐渡義一, 二宮善文, 大塚愛二

解剖学雑誌 80 ( Suppl. ) 151 - 151 2005年3月

ヒト皮膚および付属器の基底膜IV型コラーゲンα鎖構成

長谷川治子, 内藤一郎, 中野和代, 米澤朋子, 西田圭一郎, 田口勇仁, 佐渡義一, 二宮善文, 大塚愛二

解剖学雑誌 80 ( 1 ) 20 - 20 2005年3月

川崎啓介, 杉原進介, 大塚愛二, 西田圭一郎, 尾崎敏文, 吉田晶, 井上一

移植 40 ( 1 ) 78 - 79 2005年2月

Three-dimensional ultrastructure of the brush border glycocalyx in the mouse small intestine: a high resolution scanning electron microscopic study

K Horiuchi, Naito, I, K Nakano, S Nakatani, K Nishida, T Taguchi, A Ohtsuka

ARCHIVES OF HISTOLOGY AND CYTOLOGY 68 ( 1 ) 51 - 56 2005年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：INT SOC HISTOLOGY & CYTOLOGY

The three-dimensional ultrastructure of the filamentous glycocalyx of the brush border in the mouse small intestine was successfully demonstrated by high resolution scanning electron microscopy (SEM). The specimens were fixed with 2% glutaraldehyde in a 0.1 M phosphate buffer (pH 7.4), and rinsed with buffered solutions with differently adjusted pH values (pH 3.0, 7.0 or 11.0). They were then osmicated, dried, spatter-coated with gold (1.0-1.5 nm), and observed under a high resolution SEM. The glycocalyx on the luminal surface of the intestinal villi covered the top of the microvilli of the epithelial cells and were well preserved in the specimens treated with an alkaline buffer (pH 11.0). The glycocalyx was observed as filamentous structures, 7 to 15 nm thick in diameter. These filaments repeatedly branched and anastomosed with neighboring ones to form an actual network or plexus as a whole, in contrast with superimposed images in transmission electron microscopy (TEM) which suggested that such anastomoses were pseudo-networks. The filaments thickened globularly at the sites of the filament bifurcation or branching. On the other hand, specimens rinsed with an acid or neutral buffer showed no glycocalyx on their microvilli, whose naked top had knob-like structures. Thus, the pH values of the washing buffer solutions were considered to affect the preservation of the surface coat due to molecular characteristics.

DOI： 10.1679/aohc.68.51

Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage

S Omoto, K Nishida, Y Yamaai, M Shibahara, T Nishida, T Doi, H Asahara, T Nakanishi, H Inoue, M Takigawa

OSTEOARTHRITIS AND CARTILAGE 12 ( 10 ) 771 - 778 2004年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：W B SAUNDERS CO LTD

Objective: The investigation of the expression and localization of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24/CCN family member 2 (CTGF/Hcs24/CCN2) in normal and osteoarthritic (OA) cartilage, and quantification of CTGF/Hcs24-positive cells.
Methods: Cartilage samples of patients (n = 20) with late stage CA were obtained at total joint replacement surgery. Morphologically normal cartilage was harvested for comparison purposes from the femoral heads of 6 other patients with femoral neck fracture. Paraffin -embedded sections were stained by Safranin O. The severity of the OA lesions was divided into four stages (normal, early, moderate, and severe). The localization of protein and mRNA for CTGF/Hcs24 was investigated by immunohistochemistry and in situ hybridization, respectively. The population of CTGF/Hcs24-positive chondrocytes in CA cartilage and chondro-osteophyte was quantified by counting the number of the cells under light microscopy.
Results: Signals for CTGF/Hcs24 were detected in a small percentage of chondrocytes throughout the layers of normal cartilage. In early stage CA cartilage, the CTGF/Hcs24-positive chondrocytes were localized mainly in the superficial layer. In moderate to severe OA cartilage, intense staining for CTGF/Hcs24 was observed in proliferating chondrocytes forming cell clusters next to the cartilage surface. In chondro-osteophyte, strong signals were found in the chondrocytes of the proliferative and hypertrophic zones.
Conclusion: CTGF/Hcs24 expression was detected in both normal and OA chondrocytes of human samples. The results of the current study suggested that expression of CTGF/Hcs24 was concomitant with development of CA lesions and chondrocyte differentiation in chondro-osteophyte. (C) 2004 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.joca.2004.06.009

Histone deacetylase inhibitor suppression of auto antibody-mediated arthritis in mice via regulation of p16(INK4a) and p21(WAF1/Cip1) expression

K Nishida, T Komiyama, S Miyazawa, ZN Shen, T Furumatsu, H Doi, A Yoshida, J Yamana, M Yamamura, Y Ninomiya, H Inoue, H Asahara

ARTHRITIS AND RHEUMATISM 50 ( 10 ) 3365 - 3376 2004年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Objective. To examine whether depsipeptide (FK228), a histone deacetylase (HDA) inhibitor, has inhibitory effects on the proliferation of synovial fibroblasts from rheumatoid arthritis (RA) patients, and to examine the effects of systemic administration of FK228 in an animal model of arthritis.
Methods. Antoantibody-mediated arthritis (AMA) was induced in 19 male DBA/1 mice (6-7 weeks old); 10 of them were treated by intravenous administration of FK228 (2.5 mg/kg), and 9 were used as controls. The effects of FK228 were examined by radiographic, histologic, and immunohistochemical analyses and arthritis scores. RA synovial fibroblasts (RASFs) were obtained at the time of joint replacement surgery. In vitro effects of FK228 on cell proliferation were assessed by MTT assay. Cell morphology was examined by light and transmission electron microscopy. The effects on the expression of the cell cycle regulators p16(INK4a) and p21(WAF1/Cip1) were examined by real-time polymerase chain reaction and Western blot analysis. The acetylation status of the promoter regions of p16(INK4a) and p21(WAF1/Cip1) were determined by chromatin immunoprecipitation assay.
Results. A single intravenous injection of FK228 (2.5 mg/ml) successfully inhibited joint swelling, synovial inflammation, and subsequent bone and cartilage destruction in mice with AMA. FK228 treatment induced histone hyperacetylation in the synovial cells and decreased the levels of tumor necrosis factor a and interleukin-1beta in the synovial tissues of mice with AMA. FK228 inhibited the in vitro proliferation of RASFs in a dose-dependent manner. Treatment of cells with FK228 induced the expression of p16(INK4a) and up-regulated the expression of p21(WAF1/Cip1). These effects of FK228 on p16(INK4a) and p21(WAF1/Cip1) were related to the acetylation of the promoter region of the genes.
Conclusion. Our findings strongly suggest that systemic administration of HDA inhibitors may represent a novel therapeutic target in RA by means of cell cycle arrest in RASFs via induction of p16(INK4a) expression and increase in p21(WAF1/Cip1) expression.

DOI： 10.1002/art.20709

Influence of telomerase activity on bone and soft tissue tumors

N Umehara, T Ozaki, S Sugihara, T Kunisada, Y Morimoto, A Kawai, K Nishida, A Yoshida, T Murakami, H Inoue

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 130 ( 7 ) 411 - 416 2004年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

Purpose. Telomeres consisting of a repeating nucleotide sequence (TTAGGG)n are shortened in normal somatic cells. Telomerase is an enzyme that elongates the telomere sequence and is detected in most human cancers and usually not in normal somatic cells. Little is known about telomerase activity in bone and soft tissue tumors. The aim of this study was to investigate the relationship between telomerase activity and clinical factors in bone and soft tissue tumors. Methods. Telomerase activity was measured using the modified telomeric repeat amplification protocol (TRAP) assay in 115 bone and soft tissue tumors obtained through open biopsy or resection. Results. Telomerase activity was detected in 10% of benign tumors and 44% of malignant tumors (p<0.001). A higher incidence of telomerase activity was detected in high-grade tumors than in low-grade tumors (p=0.002). The cumulative metastasis-free and overall survival in telomerase-positive patients was significantly worse than in telomerase-negative patients (p=0.045 and p=0.048). Conclusion. Our study suggests that telomerase activity is associated with tumor aggressiveness and may be a useful parameter to predict the prognosis of patients with malignant bone and soft tissue tumors.

DOI： 10.1007/s00432-004-0553-z

抗炎症薬・抗アレルギー薬開発の最前線ヒストン脱アセチル化酵素阻害剤を用いた細胞周期制御による実験的関節炎の抑制

西田圭一郎, 小見山貴充, 宮澤慎一, 北村亜似, 申正男, 真鍋博規, 土井英之, 浅原弘嗣, 二宮善文, 大塚愛二, 井上一

炎症・再生 24 ( 4 ) 425 - 425 2004年7月

Radiological follow-up study of rheumatoid wrists after radio-lunate limited arthrodesis with ulnar head resection

Kensuke Uchida, Keiichiro Nishida, Hiroyuki Hashizume, Shunsuke Omoto, Masutaka Watanabe, Yusuke Ota, Hajime Inoue

Modern Rheumatology 14 ( 1 ) 31 - 36 2004年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

Radio-lunate limited arthrodesis (RLA) is an established surgical intervention for damaged rheumatoid arthritis (RA) wrists. The goal of RLA is to conserve the range of motion (ROM) and level of activities of daily life (ADL) by delaying more extensive fusion. In this study, we retrospectively reviewed the outcome of RLA with ulnar head resection (UHR) in terms of pain score, ROM, and radiographic parameters, including carpal height ratio, ulnar translation ratio, and palmar subluxation. The clinical factors, such as dose of corticosteroids per day and laboratory examination data before surgery, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and rheumatoid factor (RF), did not influence the results of the surgery. The changes in these clinical factors were also statistically analyzed in relation to the Schulthess classification of preoperative radiographs of wrists reported by Simmen and Huber: Type I (ankylosis type), Type II (osteoarthritis type), and Type III (disintegration type). This study hypothesized that RLA with UHR would provide no significant improvement in Type III wrists. The results showed that RLA with UHR resulted in stable wrists with excellent pain relief and with limited, but temporary, functional ROM, suggesting that this procedure seems to be applicable for all types of wrists within this group of patients. © Springer-Verlag Tokyo 2004.

DOI： 10.1007/s10165-003-0262-5

Spontaneous "spaghetti" flexor tendon ruptures in the rheumatoid wrist

Hiroyuki Hashizume, Keiichiro Nishida, Kazuo Fujiwara, Hajime Inoue

Modern Rheumatology 14 ( 3 ) 257 - 259 2004年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Japan

A 54-year-old woman who had been treated for rheumatoid arthritis for 12 years developed spontaneous multiple flexor tendon ruptures during a 5-month period. Radiography revealed volar subluxation of the lunate bone. Surgery was performed 5 months after the first onset of tendon rupture. All eight flexors, except the flexor pollicis longus tendons, had ruptured, and the damage resembled spaghetti. Four flexor digitorum profundus tendons were reconstructed by bridge graft using their respective sublimis tendons. Wrist joint fusion and tenolysis were performed 3 months after the first operation. Each finger achieved a good range of motion 2 years and 6 months after be second operation. © Japan College of Rheumatology and Springer-Verlag Tokyo 2004.

DOI： 10.3109/s10165-004-0303-8

Biomechanical analysis of the mechanism of elbow fracturedislocations by compression force

H Wake, H Hashizume, K Nishida, H Inoue, N Nagayama

JOURNAL OF ORTHOPAEDIC SCIENCE 9 ( 1 ) 44 - 50 2004年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER TOKYO

Fracture-dislocations of the coronoid and olecranon were produced experimentally, and their onset mechanisms were analyzed to clarify the effects of compression force on the coronoid and olecranon. The study used two-dimensional finite element method (2D-FEM) simulations and static loading experiments. The latter applied axial force distally to 40 cadaveric elbows. Posterior fracture-dislocations occurred between 15degrees of extension and 30degrees of flexion, anterior or posterior fracture-dislocations at 60degrees, and only anterior fracture-dislocations at 90degrees. Injuries were mainly to anterior or posterior support structures. The 2D-FEM simulations showed that the stress concentration areas moved from the coronoid process to the olecranon as position changed from extension to flexion. The very high frequency of concurrent fracture-dislocations of radial head or neck in the current study indicated that the radial head may also function as a stabilizer in the anterior support system.

DOI： 10.1007/s00776-003-0735-6

Arthroscopic surgery for traumatic triangular fibrocartilage complex injury

H Miwa, H Hashizume, K Fujiwara, K Nishida, H Inoue

JOURNAL OF ORTHOPAEDIC SCIENCE 9 ( 4 ) 354 - 359 2004年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER TOKYO

Clinical characteristics, diagnostic imaging, arthroscopic findings, and surgical results of arthroscopic treatment are reported in 62 hands with traumatic triangular fibrocartilage complex (TFCC) injury treated between 1995 and 2002. This retrospective study also describes and compares the results of a novel arthroscopic suture technique for repairing tears with Palmer's class 1B and 1D tears. According to Palmer's classification, there were 10 class 1A, 27 1B, 81C, and 17 1D injuries. The arthroscopic suture and debridement treatments were done under brachial plexus block as a L-day in-hospital procedure. Class ID tears required transradial fixation to anchor the TFCC. Surgical results of suture groups according to Minami's criteria were excellent in 16 hands, good in 15 hands, fair in 1 hand, and poor in 1 hand. The results of the debridement group were excellent in 16 hands, good in 10 hands, fair in 2 hands, and poor in 1 hand. The results of the current study indicate that the novel suture technique were easy to perform, provided strong, tight repair for class 1D injuries, and was applicable for class 1B injuries in this small case series.

DOI： 10.1007/s00776-004-0796-1

Development of a bone cutting robot for total knee arthroplasty. 査読

Hoechst 33342 is a useful cell tracer for a long-term investigation of articular cartilage repair

Kawasaki K, Sugihara S, Nishida K, Ozaki T, Yoshida A, Ohtsuka A, Inoue H

Arch Histol Cytol 67 ( 1 ) 13 - 9 2004年

Mamoru Mitsuishi, Shin'ichi Warisawa, Naohiko Sugita, N. Suzuki, Masahiko Suzuki, Hideshige Moriya, Kazuo Fujiwara, Nobuhiro Abe, Keiichiro Nishida, Hiroyuki Hashizume, H. Inoue, Takayuki Inoue, Koichi Kuramoto, Yoshio Nakashima

2004 IEEE/RSJ International Conference on Intelligent Robots and Systems, Sendai, Japan, September 28 - October 2, 2004 4 3302 - 3308 2004年

Blood loss in patients for total knee arthroplasty

N Abe, H Fujimoto, T Ozaki, K Asaumi, H Kato, K Nishida, Y Takahara, H Inoue

ANNALS OF THE RHEUMATIC DISEASES 62 497 - 497 2003年7月

Vascular endothelial growth factor principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis

T Furumatsu, ZN Shen, A Kawai, K Nishida, H Manabe, T Oohashi, H Inoue, Y Ninomiya

JOURNAL OF BIOCHEMISTRY 133 ( 5 ) 633 - 639 2003年5月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE BIOCHEMICAL SOC

Vascular endothelial growth factor (VEGF)-mediated angiogenesis is essential for bone formation. However, the effect of VEGF on osteoblastic cells during osteoblastogenesis is still controversial. The aim of this,study was to clarify the relationship between osteoblastic cells derived from human mesenchymal stem cells (MSCs). and VEGF -in the early stage of osteoblastic differentiation. Continuous dexamethasone treatment with a low concentration stimulated osteoblastogenesis of MSCs and the expression of VEGF121 mRNA. The VEGF secretion from osteoblastic cells also increased along with osteoblastogenesis. Neuropilin-1, which mainly binds VEGF165, was detected at all stages during early osteoblastogenesis, but VEGF receptor-1 and -2 were not detected on RT-PCR analyses. In this study, VEGF had no direct effect on the proliferation of osteoblastic cells. However, the secreted VEGF in the conditioned medium of osteoblastic cells exhibited high angiogenic power as to endothelial cell proliferation. Our findings indicated that VEGF121 principally acts as the main angiogenic factor in the early stage of human osteoblastogenesis. The present study also demonstrated the differential expression of VEGF121 during osteoblastogenesis. The increase of VEGF in the early stage might be a useful marker of induction of bone formation due to human MSCs.

DOI： 10.1093/jb/mvg081

リウマチ教室の経験

篠田潤子, 西田圭一郎, 千田益生, 濱田全紀, 堅山佳美, 井上一, 難波良文

リハビリテーション医学 40 ( Suppl. ) S292 - S292 2003年5月

Effect of NOS2 gene deficiency on the development of autoantibody mediated arthritis and subsequent articular cartilage degeneration

H Kato, K Nishida, A Yoshida, Takada, I, C McCown, M Matsuo, T Murakami, H Inoue

JOURNAL OF RHEUMATOLOGY 30 ( 2 ) 247 - 255 2003年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：J RHEUMATOL PUBL CO

Objective. To determine the effect of NOS2 gene deletion on articular cartilage degradation in autoantibody mediated arthritis (AMA).
Methods. Female C57BL/6Ai-[ko] NOS2 N5 (NOS2-/-) mice (7-8 weeks old) and the counterpart C57/B16 Crj mice (wild-type, WT) were studied, Arthritis was induced by intraperitoneal injection of 4 mg of an arthritogenic cocktail of 4 monoclonal antibodies raised against type II collagen twice on Day 0 and Day 1 followed by intraperitoneal injection of 50 mug of lipopolysaccharide on Day 2. Individual limbs were scored for arthritis in 4 grades; the total maximum score per mouse was 16. Femoral condyles and tibial plateaus of both knee joints were collected on Day 15 for immunohistological studies on nitrotyrosine and matrix metalloproteinase (MMP)-3 and -9. DNA fragmentation in chondrocytes was detected by the nick-end labeling (TUNEL) method. Blood was also collected on Day 15 to determine serum levels of nitrite/nitrate and interleukin 1beta (IL-1beta).
Results. Both NOS2-/- and WT mice with AMA developed clinically apparent arthritis. In WT mice, the arthritis progressed rapidly and reached the peak score 11.4 +/- 2.9 on Day 12, whereas the arthritis in NOS2-/- mice was milder and the peak score was 7.7 +/- 2.8 on Day 13 (p < 0.05). The serum nitrite/nitrate levels, histological grades of articular cartilage degradation, and numbers of apoptotic chondrocytes and nitrotyrosine positive chondrocytes were significantly lower in NOS2-/- mice with AMA than in WT mice with AMA. Conversely, significant differences were not observed in MMP-3 or -9 expression in chondrocytes, or in serum IL-1β levels between these 2 groups of mice.
Conclusion. NOS2 gene deletion did not affect the inflammatory responses, but reduced the cartilage degradation.

Blood loss in patients for total knee arthroplasty

Fujimoto, H., Ozaki, T., Asaumi, K., Kato, H., Nishida, K., Takahara, Y., Abe, N., Inoue, H.

Knee Surgery, Sports Traumatology, Arthroscopy 11 ( 3 ) 2003年

Hepatopancreatic arterial ring: Bilateral symmetric typology in human celiaco-mesenteric arterial system

M Kosaka, K Horiuchi, K Nishida, T Taguchi, T Murakami, A Ohtsuka

ACTA MEDICA OKAYAMA 56 ( 5 ) 245 - 253 2002年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The celiac and mesenteric arterial system including the left gastric, splenic, common hepatic, and superior mesenteric arteries shows various types of origins, courses, ramifications and anastomoses. In order to explain the various expressions of this system, we have proposed a typological model, in which celiacomesenteric arteries develop as paired or bilaterally symmetrical primordial vessels originated from the anterior aspect of the aorta, and these vessels anastomose each other with longitudinal and horizontal pathways. Here, we report 3 unusual cases characterized by arterial rings, formed by the left gastric, left accessory hepatic, proper hepatic, anterior pancreaticoduodenal, and dorsal pancreatic arteries. The dorsal pancreatic and anterior pancreaticoduodenal arteries are located to the right and left of the embryonic pancreas developing in the dorsal mesentery, respectively. Such hepatopancreatic arterial rings simultaneously containing right and left elements can only be explained using our typological model, in which the concept of paired arteries or bilateral symmetry is introduced.

DOI： 10.18926/AMO/31711

Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor-gamma

K Nishida, T Furumatsu, Takada, I, A Kawai, A Yoshida, T Kunisada, H Inoue

BRITISH JOURNAL OF CANCER 86 ( 8 ) 1303 - 1309 2002年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：NATURE PUBLISHING GROUP

A rare immunohistochemical study using 28 surgical sections of human chondrosarcoma revealed that 67.9% of tumour cells had weak (10-40%) or strong (> 40%) positive immunoreaction for peroxisome proliferator-activated receptor-gamma. The expression of peroxisome proliferator-activated receptor-mRNA and protein in human chondrosarcoma cell line OUMS-27 was also determined by reverse transcription-polymerase chain reaction and immunocytochemistry, respectively. Furthermore, the effects of peroxisome proliferator-activated receptor-gamma ligands on cell proliferation and survival were investigated in OUMS-27 cells. Pioglitazone, a selective ligand for peroxisome proliferator-activated receptor-gamma, and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a putative endogenous ligand for peroxisome proliferator-activated receptor-gamma, inhibited the proliferation of OUMS-27 cells in a dose-dependent manner. The mechanism of cytotoxic effects of 15d-PGJ(2) was via apoptosis as shown by DNA fragmentation using TUNEL stain and DNA ladder formation, and by ultrastructural analysis using transmission electron microscopy. Flow-cytometric analysis using annexin-V-fluorescein and propidium iodide detected the early change of apoptosis, as well as necrosis of OUMS-27 cells at 4 h after co-incubation with 15d-PGJ(2). These results suggest that peroxisome proliferator-activated receptor-gamma may play a significant role in the pathogenesis of chondrosarcoma, and peroxisome proliferator-activated receptor-gamma ligands, especially 15d-PGJ(2), may be of therapeutic value in the treatment of human chondrosarcoma. (C) 2002 dCancer Research UK.

DOI： 10.1038/sj/bjc/6600241

Endostatin inhibits adhesion of endothelial cells to collagen I via alpha(2)beta(1) integrin, a possible cause of prevention of chondrosarcoma growth

T Furumatsu, N Yamaguchi, K Nishida, A Kawai, T Kunisada, M Namba, H Inoue, Y Ninomiya

JOURNAL OF BIOCHEMISTRY 131 ( 4 ) 619 - 626 2002年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：JAPANESE BIOCHEMICAL SOC

Endostatin derived from collagen XVIII is a potent endogenous anti-angiogenic factor that induces regression of various tumors of epithelial origin. Endostatin has been shown to inhibit endothelial cell functions, however, its effect remains controversial. We first attempted here to apply the inhibitory effect of recombinant human endostatin on chondrosarcomas, which originate from the mesenchyme, in nude mice. Endostatin induced reduction of chondrosarcoma growth and tumor angiogenesis in vivo. However, endostatin showed no effect on the proliferation and migration of chondrosarcoma cells in vitro. Next, we investigated the interactions between endostatin and endothelial cells in detail. Endostatin inhibited the migration on and attachment to collagen I but did not affect the proliferation of endothelial cells. Although the migration of endothelial cells was stimulated by angiogenic factors such as basic fibroblast growth factor and vascular endothelial growth factor, endostatin showed similar inhibitory effects on it in the presence and absence of the stimulants. Moreover, the inhibitory effect against endothelial cell attachment to collagen I was attenuated or modulated in the presence of neutralizing antibodies of alpha(2), alpha(5)beta(1), and alpha(V)beta(3) integrins but not that of alpha(1) integrin. Our results suggest that endostatin might suppress the alpha(2)beta(1) integrin function of endothelial cells via alpha(5)beta(1), or alpha(V)beta(3), integrin. We propose here that endostatin might be effective for anti-angiogenic therapy for human chondrosarcomas through the suppression of alpha(2)beta(1) integrin functions in endothelial cells.

DOI： 10.1093/oxfordjournals.jbchem.a003142

Human chondrosarcoma secretes vascular endothelial growth factor to induce tumor angiogenesis and stores basic fibroblast growth factor for regulation of its own growth

T Furumatsu, K Nishida, A Kawai, M Namba, H Inoue, Y Ninomiya

INTERNATIONAL JOURNAL OF CANCER 97 ( 3 ) 313 - 322 2002年1月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：WILEY-LISS

Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are well-known factors that induce neovascularization in many tumors. The molecular mechanisms that regulate tumor angiogenesis in human chondrosarcoma are not clear. We assessed in this work the angiogenic activities of a human chondrosarcoma cell line (OUMS-27) In vivo and determined the efficacies of angiogenic factors derived from OUMS-27 cells on human umbilical vein endothelial cells (HUVECs) in vitro. Tumor xenografts induced an increase in the formation of neovessels, but the distributions of Ki-67 antigen, VEGF and bFGF were unaffected. We also demonstrated that OUMS-27 cells secreted VEGF(165) into the culture medium and that it was the maximal angiogenic factor to stimulate endothelial proliferation and migration in chondrosarcoma. Anti-VEGF antibodies induced an approximately 70% inhibition of these responses of HUVECs, but did not have any effect on OUMS-27 cells. Anti-bFGF antibodies suppressed not only the activities of HUVECs but also the growth of tumor cells in vitro. We indicate that angiogenesis is principally elicited by VEGF(165) and that tumorigenesis is mainly regulated by bFGF stored in the extracellular matrix of OUMS-27 cells. The present study may offer the availability of combination therapies for inhibition of VEGF and bFGF action on vascular endothelial cells and chondrosarcoma cells, respectively. (C) 2002 Wiley-Liss, Inc.

DOI： 10.1002/ijc.1607

Changes in LPIA D-dimer levels after total hip or knee arthroplasty relevant to deep-vein thrombosis diagnosed by bilateral ascending venography

Naofumi Shiota, Toru Sato, Keiichiro Nishida, Masatsugu Matsuo, Yasuhiro Takahara, Shigeru Mitani, Takuro Murakami, Hajime Inoue

Journal of Orthopaedic Science 7 ( 4 ) 444 - 450 2002年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：Springer Japan

The purpose of the current retrospective study was to determine the most sensitive and specific cutoff value of plasma D-dimer level associated with deep-vein thrombosis (DVT) after total hip (THA) or knee (TKA) joint arthroplasty. Diagnosis of DVT was determined by bilateral ascending venography pre- and postoperatively. Plasma D-dimer levels were measured by a latex photometric immunoassay system (LPIA) preoperatively and postoperatively on days 1, 3, 7, 10, 14, and 21. Postoperative DVT diagnosed by venography was found in 22 patients (40.1%) after THA and in 18 patients (64.3%) after TKA. Plasma D-dimer levels were significantly higher (P &lt
0.01) in patients with DVT than in those without DVT on days 1, 7, and 10 after THA, but only on day 7 after TKA. Statistical analysis confirmed that a cutoff value of 10.0 μg/ml for D-dimer on day 7 was most sensitive (THA, 95.5%
TKA, 94.4%) and most specific (THA, 96.9%
TKA, 90.0%) in the diagnosis of DVT after THA as well as TKA. It was concluded that over 10 μg/ml of LPIA D-dimer on post-operative day 7 appears to be an indication of the occurrence of DVT after THA and TKA.

DOI： 10.1007/s007760200077

Carpal tunnel syndrome grading system in rheumatoid arthritis

Junko Shinoda, Hiroyuki Hashizume, Cherie McCown, Masuo Senda, Keiichiro Nishida, Takeshi Doi, Hajime Inoue

Journal of Orthopaedic Science 7 ( 2 ) 188 - 193 2002年

記述言語：英語掲載種別：研究論文（学術雑誌）

The grading system of Hashizume and Hirooka for carpal tunnel syndrome (CTS) was modified to refine the system for surgical treatment selection for specific subsets of CTS in patients with rheumatoid arthritis (RA). The grading system uses clinical signs and symptoms of CTS, including pain indications, to identify surgical subsets of patients to facilitate treatment selection. Retrospective analysis of the system included radiographic and electromyographic findings. Twenty-nine hands of 21 adult patients with CTS in RA were graded in the current study. Eight hands with mild synovitis received conservative treatment only. Endoscopic carpal tunnel release (ECTR), using Okutsu's universal subcutaneous endoscopic system with a clear cannula, was performed in 11 hands with moderate synovitis. Open carpal tunnel release (OCTR) combined with flexor tenosynovectomy was performed in 9 hands with severe synovitis. One more hand required OCTR after ECTR when malignant RA was diagnosed. Clinical results, evaluated using Kelly's criteria, were: excellent in 19 hands, good in 5, fair in 4, and poor in the 1 patient with malignant RA. Clinical symptoms of CTS improved in all but the latter patient. Although the sample size in the current study is small, the results appear to warrant further study to determine the clinical utility of the grading system.

DOI： 10.1007/s007760200032

Evidence of oncotic cell death and DNA fragmentation in human hypertropic chondrocytes in chondro-osteophyte

Doi, T., Nishida, K., Matsuo, M., Yoshida, A., Murakami, T., Inoue, H.

Osteoarthritis and Cartilage 10 ( 4 ) 2002年

Expression of caspase-3 and-9 relevant to cartilage destruction and chondrocyte apoptosis in human osteoarthritic cartilage

M Matsuo, K Nishida, A Yoshida, T Murakami, H Inoue

ACTA MEDICA OKAYAMA 55 ( 6 ) 333 - 340 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

To clarify the involvement of the caspase family in the pathway of NO-induced chondrocyte apoptosis, osteoarthritis (OA) cartilage obtained from 8 patients undergoing total hip arthroplasty were used for histopathological study. Cartilage samples taken from non-fibrillated areas of femoral head resected during surgery for femoral neck fracture were used for comparison. DNA fragmentation of chondrocytes was detected by the nick end-labeling (TUNEL) method. Apoptosis was further confirmed by transmission electron microscopy. The distributions of nitrotyrosine (NT), caspase-3, and -9 were examined immunohistochemically. The populations of apoptotic as wen as NT-, caspase-3-, and -9-positive cells were quantified by counting the number of cells in the superficial, middle, and deep layers, respectively. The TUNEL-positive cells were observed primarily in superficial proliferating chondrocytes, clustering chondrocytes, and deep-layer chondrocytes of OA cartilage. Few positive cells were seen in the proliferating chondrocytes in the middle layer. Positive reactions for caspase-3 and -9 were observed in chondrocytes in similar areas. Histological OA grade showed significant correlations with the mean populations of apoptotic chondrocytes (% apoptosis) over the 3 areas. The populations of NT-positive cells (% NT) over the same areas also showed significant correlation with OA grade. Positivity for caspase-3 closely correlated with the OA grade, % apoptosis and %NT. It was concluded that caspase-3 and -9 could play a role in NO-induced chondrocyte apoptosis in OA cartilage.

Involvement of nitric oxide in chondrocyte cell death in chondro-osteophyte formation

K Nishida, T Doi, M Matsuo, Y Ishiwari, H Tsujigiwa, A Yoshida, M Shibahara, H Inoue

OSTEOARTHRITIS AND CARTILAGE 9 ( 3 ) 232 - 237 2001年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：W B SAUNDERS CO LTD

Objective: To examine the nitric oxide (NO) production relevant to chondrocyte cell death in order to elucidate the mechanism of chondro-osteophyte formation in osteoarthrotic joints.
Design: Human chondra-osteophytes were obtained during total hip arthroplasty. Expression of inducible nitric oxide synthase (iNOS) mRNA was determined by in-situ hybridization. Localization of iNOS and nitrotyrosine at protein level were examined by immunohistochemistry. Cell death of chondrocytes were confirmed by both TUNEL method and transmission electron microscopy.
Results: The various populations of proliferative and hypertrophic chondrocytes expressed iNOS mRNA and iNOS as well as nitrotyrosine protein. Approximately 30% at hypertrophic chondrocytes forming chondro-osteophyte showed positive reaction to TUNEL staining. Electron microscopy confirmed both disintegrated and apoptotic chondrocytes in these zones. In the deep hypertrophic zone calcification was seen around each of the matrix vesicles and some masses of cell debris.
Conclusion: Chondro-osteophyte formation involves NO production by chondrocytes. The expression and localization of iNOS and nitrotyrosine in chondro-osteophytes suggest the significant role of NO in chondrocyte hypertrophy and apoptosis. (C) 2001 OsteoArthritis Research Society international.

DOI： 10.1053/joca.2000.0380

Reconstruction of the proximal humerus with the clavicle after tumor resection: A case report

Reconstruction using clavicle afre resection of arcoma of the proximal humerus.

Ozaki T, Hashizume H, Nishida K, Kawai A, Inoue H

Clin Orthop 2001年

Ozaki, T., Hashizume, H., Kunisada, T., Kawai, A., Nishida, K., Sugihara, S., Inoue, H.

Clinical Orthopaedics and Related Research ( 385 ) 2001年

Expression of connective tissue growth factor in cartilaginous tumors

89 ( 7 ) 1466 - 1473 2000年10月

CD44 expression in soft tissue sarcomas

Kahara N, Ozaki T, Doi T, Nishida K, Kawai A, Shibahara M, Inoue H

Virchows Arch 436 ( 6 ) 574 - 578 2000年6月

Increased osteocyte apoptosis during the development of femoral head osteonecrosis in spontaneously hypertensive rat

Acta Medica Okayama 54 ( 2 ) 67 - 74 2000年4月

The role of nitric oxide in arthritic joint-a therapeutic target?

Nishida K, Doi T, Inoue H

Modern Rheumatology 10 ( 2 ) 63 - 67 2000年1月

Simultaneous fracture-dislocations of the distal and proximal interphalangeal joints

K Nakago, H Hashizume, M Senda, K Nishida, S Masaoka, H Inoue

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME 24B ( 6 ) 699 - 702 1999年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CHURCHILL LIVINGSTONE

Sixteen cases of simultaneous fracture-dislocations of both the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints in the same finger that were treated during the past 10 years were classified into three types: the swan-neck injury (dorsal fragment of the base of the distal phalanx at the DIP joint and palmar fragment of the base of the middle phalanx at the PIP joint); the double-hyperextension injury (palmar fragments at the DIP and PIP joints); and the straight-finger injury (with dorsal and palmar bone fragments at the DIP joint). The results of treatment were more satisfactory in PIP joints than in DIP joints.

DOI： 10.1054/jhsb.1999.0228

Ultrasonographic analysis of shoulder rotator cuff tears

Acta Medic Okayama 53 ( 2 ) 81 - 89 1999年4月

Expression of CD44 variants in osteosarcoma

M. Kuryu, T. Ozaki, K. Nishida, M. Shibahara, A. Kawai, H. Inoue

Journal of Cancer Research and Clinical Oncology 125 ( 11 ) 646 - 652 1999年

記述言語：英語掲載種別：研究論文（学術雑誌）

The standard form of CD44 (CD44H) is a transmembranous glycoprotein, widely distributed on a variety of human lymphoid cells, epithelial cells and tumours. CD44 has many variant forms, which are generated by alternative splicing. In recent years, CD44 has been reported to be related to the degree of tumour differentiation, tumour cell invasion, and metastasis. We investigated 44 tumour specimens in 39 patients with osteosarcoma immunochemically to analyze the expression of CD44 standard (CD44H) and variant exon-encoded gene products (CD44v3, v4, v5, v6, v7, v9, and v10). Furthermore, the relationship between CD44 expression and the clinical outcome of patients with osteosarcoma was analyzed. Membrane accentuation and exclusive cytoplasmic reactivity were analyzed as separate staining patterns. Tumour cells and some multinucleated giant cells were markedly stained. CD44H, v3, v4, v5, v6, v7, v9, and v10 were expressed in 85%, 49%, 54%, 59%, 46%, 5%, 28%, and 10% of the specimens respectively. The cumulative 5-year metastasis-free survival was 58% in CD44v6-negative cases and 24% in CD44v6-positive cases (P = 0.046). However, the cumulative 5-year metastasis-free survival was not significantly different between cases positive and negative for other variants of CD44. Multivariate analysis (Cox proportional-hazard model) with CD44v6 expression (positive or negative), chemotherapy (intensive or non-intensive), tumour site (proximal or distal), and age (at least 30 years or less than 30 years) showed that expression of CD44v6 and chemotherapy were important prognostic factors in patients with osteosarcoma. Overexpression of CD44 isoforms containing variant v6 is correlated with poor prognosis in patients with osteosarcoma.

DOI： 10.1007/s004320050329

Evaluation of Rheumatoid Arthritis Using a Scoring System Devised from Magnetic Resonance Imaging of Rheumatoid Knees

Ultrasonographic analysis of shoulder cuff tearsUltrasonographic analysis of shoulder cuff tears

Masaoka S, Hashizume H, Senda M, Nishida K

Acta MEd Okayama 1999年

Integrin-regulated sevreton of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes

Millward-Sadler SJ, Wright MO, Lee H, Nishida K, Caldwell H, Nuki J, Salter DM

J Cell Biol 145 183 - 189 1999年

Takeuchi Kazuhiro, Inoue Hajime, Yokoyama Yoshiki, Senda Masuo, Ota Yusuke, Abe Nobuhiro, Nishida Keiichiro

Acta Medica Okayama 52 ( 4 ) 211 - 224 1998年8月

記述言語：英語出版者・発行元：Okayama University Medical School

We studied the magnetic resonance imaging (MRI) of 120 knees in 86 rheumatoid arthritis (RA) patients and of 14 unaffected knees in 12 control cases. We also developed a scoring system as a quantitative analysis method. We divided the MRI into 10 items, and classified the severity of the symptoms into 4 grades (score 0 to 3). The average total score increased according to the radiographic grade. Soft tissue lesions were clearly detected, even in the early stages of RA. Items such as synovial proliferation showed a high score even in the early stages, suggesting that it was the initial symptom of RA. The score also showed a correlation with the inflammatory signs. These results suggest that this scoring system is very sensitive and yields a good reflection of RA activity. We demonstrated that this system is simple and convenient for routine diagnostic use. We further demonstrated that it is useful for following the advancement of RA and for evaluating the response to treatment.

DOI： 10.18926/AMO/31296

Fibrous structure and connection surrounding the metacarpophalangeal joint.

Takagoshi H, Hashizume H, Nishida K, Masaoka S, Asahara H, Inoue H

Acta Medica Okayama 52 ( 1 ) 19 - 26 1998年2月

Mast cells in osteoarthritic and rheumatoid arthritic synovial tissues of the knee.

Acta Medica Okayama 52 ( 1 ) 35 - 39 1998年2月

A Pathogenic role for IL-12 in maintaining Th1 immuneresponses in rheumatoid arthritis.

Morita Y, Yamamura M, Nishida K, Harada S, Okamoto H, Inoue H, Ohmoto Y, Modlin RL, Makino H

Arthritis Rheum 41 306 - 314 1998年

慢性関節リウマチの手指屈筋腱腱鞘炎

太田裕介, 井上一, 橋詰博行, 西田圭一郎, 浅原弘嗣, 臼井正明, 阿部信寛

岡山県立大学短期大学部研究紀要 ( 5 ) 37 - 44 1998年

記述言語：日本語出版者・発行元：岡山県立大学短期大学部

［概要］慢性関節リウマチ（RA）において手指屈筋腱腱鞘炎（腱鞘炎）を起こす例をしばしば認めるため，横断調査を行った。［対象，方法］岡山大学整形外科リウマチ外来に通院している52例（男６例，女46例）で平均年齢59.5歳（24～85歳），平均罹病期間9.2年（2～30年）を対象とし，視診および触診にて腱鞘炎，弾発現象，ロッキングの有無，および弾発現象の既往につき調査した。調査期間は平成９年４月～５月の２ヵ月間であった。［結果］腱鞘炎を25例（48％）63指に認めた。全63指中，母指～小指が各々4，12，14，19，14指と環指に多かった。１指発生が10例と最も多かったが８指発生も２例あり，うち１例は両手指廃用であった。弾発現象を９例（17％）11指に認め，中指２指，環指５指，小指４指と環指に多い傾向を認めた。ロッキングは４例（８％）５指に認め，手指基節掌側に３例，母指基節掌側に１例認めたが，痛みはなく，日常生活動作の障害はわずかであった。弾発現象の既往のある25例中２例が手術を受けていたが９例（17％）が放置にて治癒していた。また４例はRAの初発症状として弾発現象を認めた。［考察］弾発現象は放置しても自然に消失することが多いので，短期的には経過観察でもよいが，腱断裂を起こす例もあるので，注意が必要と思われた。［まとめ］日常診療において手指屈筋腱腱鞘炎の存在に留意し，腱鞘内注射が有効でない場合は手術的治療も考慮すべきと思われた。

DOI： 10.15009/00000959

その他リンク： http://id.nii.ac.jp/1212/00000959/

慢性関節リウマチにおける手関節のＭＲＩ

正岡俊二, 橋詰博行, 西田圭一郎, 浅原弘嗣, 井上一

中国・四国整形外科学会雑誌 10 ( 2 ) 325 - 329 1998年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

Magnetic resonance imaging (MRI) was performed in 71 wrists of 39 rheumatoid arthritis patients. There were 2 males (3 wrists) and 37 females (68 wrists) with an average age of 55.4 years. Synovial proliferation and bone erosion appeared as low intensity areas on T1-weighted MRIs and as high intensity areas on T2-weighted images. Discrimination of synovial proliferation was improved by Gd-DTPA enhancement. These lesions could be detected in early rheumatoid arthritis patients whose plain X-ray images lacked abnormal findings. We found MRI to be a useful method for detecting bone and soft tissue lesions of RA, especially of early RA patients. MRI is also useful in evaluation of drug therapy and pre-operative planning.

DOI： 10.11360/jcsoa1989.10.325

Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis

Morita, Y., Yamamura, M., Nishida, K., Harada, S., Okamoto, H., Inoue, H., Ohmoto, Y., Modlin, R.L., Makino, H.

Arthritis and Rheumatism 41 ( 2 ) 1998年

Negative charges bound to collagen fibrils in the rabbit articular cartilage: A light and electron microscopic study using cationic colloidal iron

60 ( 5 ) 435 - 443 1997年12月

Expression of osteonectin in articular cartilage of osteoarthritic knees.

Acta Medica Okayama 51 ( 5 ) 239 - 243 1997年10月

Hyperpolarization of cultured human chondrocytes following cyclical pressure-induced strain : Evidence for a role for α5β1 integrin as a chondrocyte mechanoreceptor.

Wright MO, Nishida K, Bavington C, Godolphin JL, Dunne E, Walmsley S, Jobanputra P, Nuki G, Salter DM

Journal of Orthopaedic Research 15 ( 5 ) 742 - 747 1997年9月

Percutaneous release for trigger finger in idiopathic and hemodialysis patients

Acta Medica Okayama 51 ( 3 ) 155 - 158 1997年6月

Histopathology and clinical results of carpal tunnel syndrome in idiopathic cases and hemodialysis patients

K Kinugasa, H Hashizume, K Nishida, Y Shigeyama, H Inoue

ACTA MEDICA OKAYAMA 51 ( 2 ) 63 - 70 1997年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

The results of the histological examinations of specimens of the tenosynovium of the flexor tendon, the epineurium and the transverse carpal ligament from two groups of Japanese patients with carpal tunnel syndrome (idiopathic and hemodialysis) were compared. Amyloid deposits, positively identified as beta(2)-microglobulin, appeared in all patients in the long-term hemodialysis group, but in no patients in the idiopathic group. Although the pathogenesis differed between the two groups, both resulted in nerve compression in the carpal tunnel. Therefore, surgical release is considered beneficial for both groups.

Non-traumatic paralysis of the posterior interosseous nerve

78B ( 5 ) 771 - 776 1996年9月

Shoulder pain in long-term haemodialysis patients - A clinical study of 166 patients

T Konishiike, H Hashizume, K Nishida, H Inoue, M Nagoshi

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 78B ( 4 ) 601 - 605 1996年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：BRITISH EDITORIAL SOC BONE JOINT SURGERY

We reviewed 166 adult patients on long-term haemodialysis, dividing them into three groups according to the presence and type of shoulder pain, The 24 patients in group A, with spontaneous pain related to a supine posture, had been under haemodialysis for significantly longer than the others, and had a much higher incidence of carpal tunnel syndrome,
Open or arthroscopic resection of the coracoacromial ligament in 21 shoulders relieved pain during haemodialysis and night pain, and histological examination showed amyloid deposits and inflammatory-cell infiltration in the subacromial bursa in almost all cases, and in the tenosynovium of the bicipital groove in some,
We conclude that one type of shoulder pain experienced by patients on long-term haemodialysis is caused by the subacromial impingement of amyloid deposits, This should be distinguished from other types of shoulder pain, because it can be relieved by resection of the coracoacromial ligament.

Ulnar buttress arthroplasty for reconstruction after resection of the distal ulna for giant cell tumor 査読

H Hashizume, A Kawai, K Nishida, K Sasaki, H Inoue

JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME 21B ( 2 ) 213 - 215 1996年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：CHURCHILL LIVINGSTONE

A giant cell tumour of the distal end of the ulna was treated by en bloc resection, The resected distal end of the ulna was replaced by an iliac bone graft, preserving the triangular fibrocartilage complex, The wrist was pain-free and had a full range of motion 6 months postoperatively.

Histopathology of Kienboeck''s disease : Correlation with magnetic resonance and other imaging techniques.

Hashizume H, Asahara H, Nishida K, Inoue H, Konishiike T

J. Hand Surg. (British and European Volume) 21 ( 1 ) 89 - 93 1996年

Dorsally displaced epiphyseal fracture of the phalangeal base

H. Hashizume, K. Nishida, D. Mizumoto, H. Takagoshi, H. Inoue

Journal of Hand Surgery 21 ( 1 ) 136 - 138 1996年

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Churchill Livingstone

A dorsally displaced epiphyseal fracture of the middle phalanx (Salter-Harris Type I) is described. The epiphyseal fragments were attached to the central slip of the extensor tendon and collateral ligaments. The articular surface of the PIP joint was intact and smooth. The epiphysis was reduced and fixed without cutting the central slip or the collateral ligaments 8 months after injury. This kind of fracture can occur in the PIP and DIP joints, and presents special diagnostic difficulties. Open reduction is evidently necessary to correct the displacement.

DOI： 10.1016/S0266-7681(96)80030-1

The Galeazzi-equivalent lesion in children revisited

21 ( 4 ) 455 - 457 1996年

Histological and scanning electron microscopic study on the glenoid labrum of cadavers.

Nishida K, Hashizume H, Toda K, Inoue H

Journal of Shoulder and Elbow Surgery 5 ( 2 ) 132 - 138 1996年

Localization of the glycosaminoglycans in the synovial tissues from osteoarthritic knees

K Nishida, H Inoue, K Toda, T Murakami

ACTA MEDICA OKAYAMA 49 ( 6 ) 287 - 294 1995年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Localization of the glycosaminoglycans (GAG) was examined in the synovial membranes of petients with osteoarthritis under light microscopy using a fine cationic colloidal iron staining method combined with enzymatic digestion. Our staining method was very useful for demonstrating the difference in the localization of GAG in regions of the inflammatory site in the osteoarthritic synovial membrane. Hyarulonic acid was mainly located in connective tissues in the surface intercellular and perivascular spaces, chondroitin sulfate A/C in the highly fibrous part of and connective tissue around blood vessels, dermatan sulfate (chondroitin sulfate B) in the subsurface interstitium and vascular endothelial cells and heparan sulfate in part of vascular endothelial cells. No keratan sulfate was detected. GAG is reported to have an important role in cell movement, adherence and aggregation in the inflammatory sites. These findings should be useful for understanding the role of GAG in physiological and pathologic processes of secondary synovitis.

DOI： 10.18926/AMO/30384

Immunohistochemical demonstration of fibronectin in the most superficial layer of normal rabbit articular cartilage.

Annals of the Rheumatic Diseases 54 ( 12 ) 995 - 998 1995年12月

Delayed posterior interosseous nerve palsy

Hashizume H, Nishida K, Yamamoto K, Hirooka T, Inoue H

J. Hand Surg. (British and European Volume) 20B ( 5 ) 655 - 657 1995年10月

STRONGLY ANIONIC SITES IN PERIPHERAL AXONS OF THE RAT SCIATIC-NERVE - LIGHT AND ELECTRON-MICROSCOPIC DETECTION USING CATIONIC COLLOIDAL IRON

K TODA, K NISHIDA, H INOUE, A OHTSUKA, T MURAKAMI

ARCHIVES OF HISTOLOGY AND CYTOLOGY 58 ( 4 ) 485 - 492 1995年10月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：INT SOC HISTOLOGY & CYTOLOGY

Anionic sites in the rat sciatic nerve mere studied by light and electron microscopy using a fine-granular cationic colloidal iron staining method (Mu-RAKAMI et al., 1986). The axon, as well as the endoneurium, the epineurium and the basement membrane of Schwann cells, were all confirmed to react strongly to the cationic colloidal iron even at a pH value of 1.0-2.0. Prior hyaluronidase digestion decreased the colloidal stain of the epineurium; chondroitinase ABC weakened that of the endoneurium and the basement membrane of Schwann cells. However, as axons retained stainability with cationic colloidal iron even after combined digestion with hyaluronidase, chondroitinase ABC, heparitinase and keratanase, the authors consider sulfated glycoconjugates and not those substances which are digestible with such common enzymes. The acid groups ionized at pH 1.0 are most likely sulfate groups. Methylation deprived the axon of the reactivity to cationic colloidal iron staining, and even subsequent saponification could not recover this reactivity to its full extent. All these suggested the presence of sulfate groups. In the axon, electron microscopy revealed a deposition of colloidal iron on the external surfaces of microtubules and neurofilaments in the axoplasm and of very fine filaments connecting them. This highly negatively charged intra-axonal network could also serve toward a supportive function in maintaining the spatial distribution of microtubules either mechanically or through electrostatic repulsion or, possibly, serve as an intra-axonal cation exchange reservoir.

DOI： 10.1679/aohc.58.485

良性骨腫ように対する合成ハイドロキシアパタイトの使用経験

Intraneural ganglion of the posterior interosseous nerve with lateral elbow pain

20 ( 5 ) 649 - 651 1995年

国定俊之, 川井章, 杉原進介, 西田圭一郎, 濱田全紀, 井上一

中国・四国整形外科学会雑誌 7 ( 1 ) 7 - 12 1995年

記述言語：日本語出版者・発行元：The Chugoku-Shikoku Orthopaedic Association

We applied hydroxyapatite (HAP) grafting clinically for 10 patients with defects produced by a curettage of benign bone tumors. The average follow up after surgery was 29 months (range 4 to 53 months). Physical and hematological findings during this period did not show any abnormalities. The radiographic evaluation of the incorporation of the implant was divided into four stages based on marginal findings and homogeneity of the grafted HAP. The margin of HAP became possibly unclear (stage II) an average of 3 months after surgery, and almost homogeneous with the surrounding bone (stage III) 11 months after surgery.

DOI： 10.11360/jcsoa1989.7.7

Cystic radio-lucency of carpal bones in haemodialysis patients.

Konishiike T, Hashizume H, Nishida K, Inoue H, Nanba T

Journal of Hand Surgery(British and European Volume) 19B ( 5 ) 630 - 635 1994年10月

Cubital tunnel syndrome in a patient in long-term haemodialysis

T. Konishiike, H. Hashizume, K. Nishida, H. Inoue, K. Moriwaki

Journal of Hand Surgery 19 ( 5 ) 636 - 637 1994年

記述言語：英語掲載種別：研究論文（学術雑誌）

The onset mechanism of cubital tunnel syndrome and carpal tunnel syndrome may be similar in haemodialysis patients. Carpal tunnel syndrome is well recognized as a consequence of dialysis-associated amyloidosis. This case report documents the development of cubital tunnel syndrome in a patient on haemodialysis treatment for 10 years. Proliferating granulation tissue at the elbow had entrapped and displaced the ulnar nerve. This was corrected surgically, and the patient experienced immediate relief of the numbness and the "tingling", but the muscular atrophy had not improved after 8 months. © 1994.

DOI： 10.1016/0266-7681(94)90133-3