Faculty Profiles - MASUYAMA Hisashi

MISC - MASUYAMA Hisashi

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Paclitaxel投与時の筋肉痛・関節痛に対する芍薬甘草湯，L-Glutamineの効果

長谷川幸清, 水谷靖司, 倉本博行, 長尾昌二, 増山寿, 本郷淳司, 児玉順一, 吉野内光夫, 平松祐司, 工藤尚文, 奥田博之

癌と化学療法 29 569 - 574 2002

妊娠時、および帝王切開時の子宮筋腫核出術

平松祐司, 増山寿, 水谷靖司, 洲脇尚子, 工藤尚文

日本生殖外科学会雑誌 2002

妊娠糖尿病管理上の問題点

藤原美佐保, 平松祐司, 水谷靖司, 増山寿, 工藤尚文

日本産科婦人科学会中国四国合同地方部会雑誌 2002

116 Diacylglycerol(DAG)-Protein Kinase C(PKC)cascade異常とdiabetic embryopathy

平松祐司, 増山寿, 水谷靖司, 工藤尚文

日本産科婦人科學會雜誌 54 ( 2 ) 281 - 281 2002

P-523 Parathyroid Hormone-related Protein(PTHrP)が腫瘍マーカーとして有用であった卵巣明細胞癌の一例

洲脇尚子, 増山寿, 水谷靖司, 児玉順一, 平松祐司, 工藤尚文

日本産科婦人科學會雜誌 54 ( 2 ) 561 - 561 2002

Coexistence of Graves' disease and struma ovarii: Case report and literature review

Y Mimura, M Kishida, H Masuyama, N Suwaki, J Kodama, F Otsuka, H Kataoka, T Yamauchi, T Ogura, T Kudo, H Makino

ENDOCRINE JOURNAL 48 ( 2 ) 255 - 260 2001.4

Language：English Publishing type：Book review, literature introduction, etc. Publisher：JAPAN ENDOCRINE SOCIETY

We report a rare case of Graves' disease associated with struma ovarii. A 26-year-old Japanese woman had preexisting Graves' disease and was positive for TSH receptor antibody. She had been on antithyroid medication at presentation. She noted a mass in the lower left abdomen, which was diagnosed as a left struma ovarii by radiological work-up including computed tomography, magnetic resonance imaging and scintigraphy. The surgically excised teratomatous tumor, containing cystic spaces with thyroid tissue, was histologically proved to be struma ovarii. Since thyroid function tests and TSH receptor antibody did not change after surgery, her hyperthyroidism was considered to be due to Graves' disease. Our case was diagnosed as struma ovarii before surgery using various imaging studies.

DOI： 10.1507/endocrj.48.255

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The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse

H Masuyama, Y Hiramatsu, Y Mizutani, H Inoshita, T Kudo

MOLECULAR AND CELLULAR ENDOCRINOLOGY 172 ( 1-2 ) 47 - 56 2001.2

Language：English Publisher：ELSEVIER SCI IRELAND LTD

Recently, pregnane X receptor (PXR) has been described to mediate the genomic effects of several steroid hormones, such as progesterone (P), glucocorticoid (Dex), pregnenolone (Preg), and xenobiotics through the cytochrome P-450 3A gene family (CYP3A), which are monooxygenases, responsible for the oxidative metabolism of some endogenous substrates and xenobiotics. In the present study, we used a transient transfection reporter gene expression assay of COS-7 cells to demonstrate that P, Dex and Preg significantly stimulate PXR-mediated transcription at relatively high concentration comparable with that of progesterone near term pregnancy. In yeast two-hybrid protein interaction assay, PXR interacted with nuclear receptor coactivator proteins, SRC1, RIP140, and SUGI in a ligand-dependent manner. The expression of PXR mRNA was observed in the liver, intestine, uterus, ovary and placenta. The expressions of PXR mRNA in the liver and ovary increased towards term about fifty-fold compared with that of non-pregnancy and decreased postpartum. Its expression in the placenta was not drastically changed towards term. CYP3A, a target gene of PXR, was also expressed in the liver, ovary, and placenta. The expressions of CYP3A mRNA as well as PXR in the liver and ovary increased about 20-fold during prenatal period. These data suggest: that PXR may play certain roles in perinatal period, possibly in the protection of the feto-maternal system from the toxic effect of endogenous steroids and foreign substrates. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

DOI： 10.1016/S0303-7207(00)00395-6

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子宮破裂

熊澤一真, 増山寿, 工藤尚文

周産期医学 31,増,249-250 2001

妊婦の栄養・食事指導の実際：貧血妊婦

工藤尚文, 増山寿

周産期医学 31,2,243-247 2001

新しいステロイド・Xenobitotics代謝調節機構の解明

増山寿, 井下秀司, 国富衛, 水谷靖司, 平松祐司, 工藤尚文

産婦人科治療 82,1,103 2001

新しい核内受容体 pregnane X receptor(PXR)

増山寿, 平松祐司, 工藤尚文

HORMONE FRONTIER IN GYNECOLOGY 8,4,365-372 2001

新しい核内受容体であるPregnane X Receptorの妊娠中及び内分泌撹乱作用における役割

増山寿, 工藤尚文

生活と環境 46,5,43-48 ( 5 ) 43 - 48 2001

Effect of Retinoids on Fetal Lung Development in the Rat,

H.Masuyama, Y.Hiramatsu, T.Kudo

Biol Neonate 2001

子宮内反症

熊澤一真, 増山寿, 工藤尚文

周産期医学 31,増,247-248 2001

397 内分泌撹乱物質のProteasomeを介したPregnane X Receptor turnoverに及ぼす影響

増山寿, 井下秀司, 国富衛, 中田高公, 水谷靖司, 平松祐司, 工藤尚文

日本産科婦人科學會雜誌 53 ( 2 ) 357 - 357 2001

妊娠中の新しいステロイドホルモン代謝調節機構の解明

増山寿, 井下秀司, 国富衛, 中田高公, 水谷靖司, 平松祐司, 工藤尚文

日本産科婦人科栄養・代謝研究会誌 2001

妊娠糖尿病スクリーニングにおける肥満妊婦の特性と診断効率改善に関する検討

深井佳恵, 平松祐司, 水谷靖司, 大橋美佐保, 増山寿, 工藤尚文, 小国信嗣, 小国美種, 大本裕之, 吉田信隆

日本産科婦人科栄養・代謝研究会誌 2001

Streptozotocin-induced diabetic pregnant rats exhibit signs and symptoms mimicking preeclampsia

G Ishihara, Y Hiramatsu, H Masuyama, T Kudo

METABOLISM-CLINICAL AND EXPERIMENTAL 49 ( 7 ) 853 - 857 2000.7

Language：English Publisher：W B SAUNDERS CO-ELSEVIER INC

The number of patients with hypertension, obesity, diabetes, and hyperlipidemia is increasing. This tendency is observed in pregnant women, in whom many obstetrical and perinatal complications occur. The prevention of these abnormalities is important in reducing perinatal mortality and the risk of coronary disease. We established a pregnant rat model with diabetes and signs and symptoms mimicking preeclampsia. On day 6 of pregnancy, streptozotocin (STZ) or citrate buffer was injected into the tail vein, After STZ administration, plasma glucose was increased within 48 hours and sustained at a high level until day 20 of pregnancy, and plasma insulin was decreased. Fetuses from STZ-treated mothers were growth-restricted, and plasma glucose was 6-fold higher in fetuses of STZ-treated versus control rats. The systolic blood pressure, urinary protein, and hematocrit were increased significantly in STZ-treated rats. Total cholesterol and triglycerides were also elevated in STZ-treated rats, but plasma leptin levels were decreased. The STZ-induced diabetic pregnant rat model exhibited preeclampsia, hemoconcentration, hyperlipidemia, hypoleptinemia, and intrauterine growth restriction. This model closely mimics the features of human pregnancy complicated by diabetes and is useful for the basic study of the pathophysiology of pregnancy with diabetes. Copyright (C) 2000 by W.B. Saunders Company.

DOI： 10.1053/meta.2000.6750

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Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription

H Masuyama, Y Hiramatsu, M Kunitomi, T Kudo, PN MacDonald

MOLECULAR ENDOCRINOLOGY 14 ( 3 ) 421 - 428 2000.3

Language：English Publisher：ENDOCRINE SOC

Recently, Pregnane X receptor (PXR), a new member of the nuclear receptor superfamily, was shown to mediate the effects of several steroid hormones, such as progesterone, glucocorticoid, pregnenolone, and xenobiotics on cytochrome P450 3A genes (CYP3A) through the specific DNA sequence for CYP3A, suggesting that PXR may play a role in steroid hormone metabolism. In this paper, we demonstrated that phthalic acid and nonylphenol, endocrine-disrupting chemicals (EDCs), stimulated PXR-mediated transcription at concentrations comparable to those at which they activate estrogen receptor-mediated transcription using a transient reporter gene expression assay in COS-7 cells. However, bisphenol A, another EDC, had no effect on PXR-mediated transcription, although this chemical significantly enhanced ER-mediated transcription. In the yeast two-hybrid protein interaction assay, PXR interacted with two nuclear receptor coactivator proteins, steroid hormone receptor coactivator-1 and receptor interacting protein 140, in the presence of phthalic acid or nonylphenol. Thus, EDC-occupied PXR may regulate its specific gene expression through the receptor-coactivator interaction. In contrast, these EDCs had no effect on the interaction between PXR and suppressor for gal 1, a component of proteasome. Finally, the expression of CYP3A1 mRNA in the liver of rats exposed to phthalic acid or nonylphenol markedly increased compared with that in rats treated with estradiol, bisphenol A, or ethanol as assessed by competitive RT-PCR. These data suggest that EDCs may affect endocrine functions by altering steroid hormone metabolism through PXR.

DOI： 10.1210/me.14.3.421

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Heavy-for-date infants: Their backgrounds and relationship with gestational diabetes

Yuji Hiramatsu, Hisashi Masuyama, Yasushi Mizutani, Takafumi Kudo, Nobutugu Oguni, Yoshitane Oguni

Journal of Obstetrics and Gynaecology Research 26 ( 3 ) 193 - 198 2000

Language：English Publisher：University of Tokyo Press

Objective: Gestational diabetes (GDM) is closely related to birth weight. Heavy-for-date (HFD) infants, especially those with macrosomia, cause many perinatal complications. This study was performed to examine the backgrounds of HFD infants and to determine such infants' relationship with GDM. Method: Eighty cases of HFD infants who were delivered from 1996 through 1998 were analyzed, The random blood-glucose level was used for screening for GDM. Results: Maternal body weight and the body-mass index before pregnancy and at delivery and the blood glucose level at the second trimester were positively correlated with birth weight. However, only 8.8% of HFD cases were detected by this screening method in the first trimester, and 11.3% of HFD cases were detected in the second trimester and only 1 case of borderline-type was detected by subsequent 75-g OGTT. Conclusions: Maternal obesity is an independent and more important risk factor for HFD infants than glucose intolerance.

DOI： 10.1111/j.1447-0756.2000.tb01310.x

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