Faculty Profiles - MASUYAMA Hisashi

MISC - MASUYAMA Hisashi

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P1-102 当科で経験したUAE後に妊娠に至った5症例についての検討(Group12 妊娠高血圧症候群1,一般演題,第60回日本産科婦人科学会学術講演会)

瀬川友功, 赤堀洋一郎, 井上誠司, 中務日出輝, 舛本明生, 住田由美, 野口聡一, 高本憲男, 増山寿, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 530 - 530 2008

P1-149 糖変動パターンによる絨毛細胞障害に関する研究(Group17 胎盤2,一般演題,第60回日本産科婦人科学会学術講演会)

舛本明生, 高本憲男, 赤堀洋一郎, 井上誠司, 中務日出輝, 住田由美, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 546 - 546 2008

P4-66 Oncostatin MとHGF(hepatic growth factor)の新生児黄疸への関与(Group101 合併症妊娠5,一般演題,第60回日本産科婦人科学会学術講演会)

中務日出輝, 増山寿, 赤堀洋一郎, 井上誠司, 舛本明生, 住田由美, 瀬川友功, 高本憲男, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 806 - 806 2008

Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells

Hisashi Masuyama, Hideki Nakatsukasa, Norio Takamoto, Yuji Hiramatsu

MOLECULAR PHARMACOLOGY 72 ( 4 ) 1045 - 1053 2007.10

Language：English Publisher：AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS

Recent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of drug-metabolizing enzymes, cytochrome P450 3A (CYP3A) family, and members of the drug transporter family, including multiple drug resistance 1 (MDR1). We demonstrated previously that steroid/xenobiotic metabolism by tumor tissue through the PXR-CYP3A pathway might play an important role in endometrial cancer and that PXR ligands enhance PXR-mediated transcription in a ligand- and promoter-dependent fashion, leading to differential regulation of individual PXR targets, especially CYP3A4 and MDR1. In this study, we investigated the potential contribution of PXR down-regulation by RNA interference toward the augmentation of drug sensitivity and the overcoming of drug resistance. We observed the protein levels of both CYP3A4 and MDR1 in PXR small interfering RNA (siRNA)-transfected cells were not increased in the presence of PXR ligands, paclitaxel, cisplatin, estradiol, or medroxyprogesterone acetate (MPA) compared with control siRNA-transfected cells. There was no PXR-mediated transactivation or augmentation of transcription by coactivators in the presence of these ligands. We then found that PXR down-regulation caused a significant increase in cell growth inhibition and enhancement of apoptosis in the presence of the anticancer agents, paclitaxel, cisplatin, and MPA. Finally, we demonstrated that PXR overexpression caused a significant decrease in cell growth inhibition and inhibited apoptosis in the presence of paclitaxel or cisplatin. These data suggest that PXR down-regulation could be a novel therapeutic approach for the augmentation of sensitivity to anticancer agents, or to overcome resistance to them, in the treatment of endometrial cancer.

DOI： 10.1124/mol.107.037937

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Correlation between soluble endoglin, vascular endothelial growth factor receptor-1, and adipocytokines in preeclampsia

Hisashi Masuyama, Hideki Nakatsukasa, Norio Takamoto, Yuji Hiramatsu

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 92 ( 7 ) 2672 - 2679 2007.7

Language：English Publisher：ENDOCRINE SOC

Context: Recent reports have demonstrated that soluble endoglin (sEng), an antiangiogenic protein thought to impair TGF-beta binding to receptors, and soluble vascular endothelial growth factor receptor (sVEGFR)-1 play important roles in the pathophysiology of pre-eclampsia ( PE). Moreover, insulin resistance, which is greatly influenced by adipocytokines, characterizes PE.
Objectives: We examined possible links between sEng, VEGF, sVEGFR, and adipocytokines in the pathophysiology of PE.
Study Design: We performed a cross-sectional study in 30 PE patients and controls matched for gestational age and body mass index. Blood samples were collected soon after disease onset. We measured serum concentrations of leptin, adiponectin, sEng, VEGF, placental growth factor (PlGF), and sVEGFR [soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble fetal liver kinase 1 (sFlk-1)], and examined the placental protein content of sEng and sFlt-1.
Results: sEng concentrations in PE patients (60.9 +/- 28.8 ng/ml) were significantly higher than those in controls (11.2 +/- 4.4 ng/ml). There was a significant correlation between sEng and sFlt-1 or PlGF. Moreover, there were significant differences in mean blood pressure between the high and low sEng groups, and in proteinuria between the high and low sFlt- 1 groups, and significant differences in placental sEng and sFlt- 1 contents between patients with and without severe hypertension or proteinuria. sEng was also correlated positively with adiponectin levels and negatively with the leptin to adiponectin ratio.
Conclusions: Along with sFlt-1 and PlGF, sEng might play a role in the pathophysiology of PE, especially in elevating blood pressure, while the association with hypoadiponectinemia and the high leptin to adiponectin ratio in pregnancy seem to be risk factors for PE.

DOI： 10.1210/jc.2006-2349

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Expression and potential role of peroxisome proliferator-activated receptor gamma in the placenta of diabetic pregnancy

N. Suwaki, H. Masuyama, A. Masumoto, N. Takamoto, Y. Hiramatsu

PLACENTA 28 ( 4 ) 315 - 323 2007.4

Language：English Publisher：W B SAUNDERS CO LTD

Peroxisome proliferator-activated receptor gamma (PPAR gamma) is expressed predominantly in adipose tissue and is known to be involved in adipocyte differentiation and insulin sensitivity. Recent reports indicated that PPAR gamma-deficient mice were embryonic lethal due to abnormal placental development, suggesting that PPAR gamma plays an important role in normal development of placenta. On the other hand, expression of vascular endothelial growth factor (VEGF), the other important factor in placental development, has been demonstrated to be regulated by PPAR gamma in vascular smooth muscle cells. Also, diabetic pregnancy is often associated with defective placental functions. In order to investigate physiological roles of PPAR gamma and VEGF in placental development during diabetic pregnancy, we examined the expressions of PPAR gamma and VEGF in placentas, which were obtained from normal and streptozotocin-induced diabetic pregnant mouse, and studied in vitro effects of hyperglycemic condition and PPAR gamma ligands (rosiglitazone and 15-deoxy-delta(12,14)prostaglandin J(2)) on trophoblasts using human choriocarcinoma cell lines. In diabetic mouse placentas (n = 5), expressions of PPAR gimel and VEGF proteins significantly increased as compared with these in normal placenta (n = 3 or 4). In vitro studies indicated that hyperglycemic condition (42 mM) significantly enhanced the PPAR gamma expression and hCG production, and significantly suppressed cell proliferation, however these effects were attenuated by PPAR gamma ligands that accompanied with increased VEGF production. These data suggest that the PPAR gamma pathway might be involved in the impairment of placental development induced by high glucose conditions, and that VEGF might play some roles in this pathway. (c) 2006 Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.placenta.2006.04.002

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妊娠高血圧症候群と代謝異常

平松祐司, 増山寿, 洲脇尚子

周産期医学 37 ( 9 ) 1115 - 1120 2007

Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia

Kumiko Hirokoshi, Yohei Maeshima, Kazuko Kobayashi, Eiji Matsuura, Hitoshi Sugiyama, Yasushi Yamasaki, Hisashi Masuyama, Yuji Hiramatsu, Hirofumi Makino

NEPHRON CLINICAL PRACTICE 106 ( 1 ) C43 - C50 2007

Language：English Publisher：KARGER

Background: An imbalance of angiogenesis-associated factors may predispose to preeclampsia. Here, we determined the ratio of serum concentration of soluble fms-like tyrosine kinase 1 (sFlt-1), a natural inhibitor of pro-angiogenic vascular endothelial growth factor (VEGF) relative to angiopoietin-2 (Ang-2), a natural antagonist of angiopoietin-1 (Ang-1) involved in promoting angiogenesis in the presence of VEGF, in women with preeclampsia. Methods: The levels of serum sFlt-1 and Ang-2 were measured by enzyme-linked immunosorbent assay. Results: Significant decrease of serum Ang-2 and the increase of sFlt-1 were observed in women with preeclampsia as compared to healthy pregnant women. The serum sFlt-1/Ang-2 ratio was strikingly increased in preeclamptic women in contrast to healthy pregnant women exhibiting lower value similar to non-pregnant women. The serum sFlt1 concentrations tended to positively correlate with mean blood pressure (BP) in preeclamptic women, but not in healthy pregnant women. A cut-off value > 0.25 in the serum sFlt-1/Ang-2 ratio showed 87.1% sensitivity and 82.8% specificity in differentiating preeclamptic women from healthy pregnant women. Conclusion: The serum sFlt-1/Ang-2 ratio is significantly elevated in preeclamptic women as compared to healthy pregnant women. Remarkable difference of sFlt-1/Ang-2 ratio between these two groups with excellent specificity and sensitivity suggests the clinical usefulness of the serum sFlt-1/Ang-2 ratio in diagnosing and potentially predicting the onset of preeclampsia. Copyright (c) 2007 S. Karger AG, Basel.

DOI： 10.1159/000101483

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わが国の周産期医療の現況と周産期オープンシステム

平松祐司, 増山寿, 野口聡一

岡山県母性衛生 23 25 - 26 2007

Gestational transient hyperthyroidismを伴ったMirror症候群の一例

井上誠司, 妹尾絵美, 住田由美, 瀬川友功, 高本憲男, 野口聡一, 増山寿, 平松祐司

日本周産期・新生児医学会雑誌 43 ( 4 ) 1079 - 1082 2007

産婦人科領域における止血のための動脈塞栓術

田村正明, 前林俊也, 正岡直樹, 山本樹生, 平松祐司, 三橋直樹, 福地剛, 増山寿, 寺尾泰久

産婦人科手術 ( 18 ) 171 - 174 2007

前回帝王切開後の前置胎盤と癒着胎盤に対する対処法

寺尾泰久, 竹田省, 木下勝之, 平松祐司, 三橋直樹, 福地剛, 正岡直樹, 増山寿

産婦人科手術 ( 18 ) 175 - 181 2007

糖尿病と胎盤

平松祐司, 洲脇尚子, 増山寿

産科と婦人科 74 ( 7 ) 829 - 834 2007

P1-541 肥満妊娠高血圧症候群患者における血管増殖因子とadipocytokineの関与(Group67 妊娠高血圧症候群1,一般演題,第59回日本産科婦人科学会学術講演会)

洲脇尚子, 増山寿, 赤堀洋一郎, 中務日出輝, 井上誠司, 舛本明生, 住田由美, 瀬川友功, 高本憲男, 平松祐司

日本産科婦人科學會雜誌 59 ( 2 ) 529 - 529 2007

P2-494 当科における産道GBS陽性妊婦の児の感染状況について(Group169 周産期感染症2,一般演題,第59回日本産婦人科学会学術講演会)

住田由美, 赤堀洋一郎, 井上誠司, 舛本明生, 洲脇尚子, 瀬川友功, 高本憲男, 野口聡一, 増山寿, 平松祐司

日本産科婦人科學會雜誌 59 ( 2 ) 728 - 728 2007

P1-95 子宮体癌におけるCOUP-TFIIの発現について(Group8 子宮体部腫瘍1,一般演題,第59回日本産科婦人科学会学術講演会)

赤堀洋一郎, 高本憲男, 中村圭一郎, 中務日出輝, 井上誠司, 舛本明生, 洲脇尚子, 住田由美, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 59 ( 2 ) 380 - 380 2007

Hypoadiponectinemia and circulating angiogenic factors in overweight patients complicated with pre-eclampsia

Naoko Suwaki, Hisashi Masuyama, Hideki Nakatsukasa, Akio Masumoto, Yumi Sumida, Norio Takamoto, Yuji Hiramatrsu

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 195 ( 6 ) 1687 - 1692 2006.12

Language：English Publisher：MOSBY-ELSEVIER

Objective: Obesity is a risk factor for pre-eclampsia, and adiponectin is an important adipocyte-derived hormone that might protect the endothelium. Recent reports have underlined importance of circulating angiogenic factors for pathophysiology of pre-eclampsia. Here we examined whether adiponectin in conjunction with angiogenic factors plays some roles in the pathophysiology of pre-eclampsia.
Study design: We measured serum concentrations of adiponectin and angiogenic factors, vascular endothelial growth factor, placental growth factor, and the soluble vascular endothelial growth factor receptors, soluble fins-like tyrosine Kinase 1 (sFlt-1) and soluble fetal liver kinase 1 (sFik-1), in women with pre-eclampsia and healthy pregnant women. We also investigated the differences of these factors in overweight and normal-weight patients with pre-eclampsia.
Results: Significant correlations were found among the circulating adiponectin and angiogenic factors placental growth factor (R = 0.772, P = .0012) and sFlt-1 (R = 0.787, P = .0005); while, no correlation was found between adiponectin and sFlk-1 (R = 0.3, P = .3434) in patients with pre-eclampsia. Overweight patients with pre-eclampsia showed significantly lower adiponectin levels and a mild imbalance of circulating angiogenic factors, compared with normal-weight patients with pre-eclampsia.
Conclusion: Overweight women with pre-eclampsia appeared to have lower levels of adiponectin and sFlt1 and higher levels of placental growth factor than women with pre-eclampsia who were of normal weight. These results suggest that hypoadiponectinemia might be involved in the pathophysiology of overweight patients with pre-eclampsia. (c) 2006 Mosby, Inc. All rights reserved.

DOI： 10.1016/j.ajog.2006.04.003

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Parathyroid hormone-related protein as a potential tumor marker: A case report of ovarian clear cell carcinoma

N Suwaki, H Masuyama, Y Mizutani, J Kodama, Y Hiramatsu

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 32 ( 1 ) 94 - 98 2006.2

Language：English Publisher：BLACKWELL PUBLISHING

Hypercalcemia is one of the important paraneoplastic syndromes, mostly occurring in patients with advanced cancer. Clear cell carcinoma is known to be one of the most common histological subtypes of ovarian tumor associated with hypercalcemia. We present a case of ovarian clear cell carcinoma with hypercalcemia caused by elevated serum parathyroid hormone-related protein (PTHrP). PTHrP mRNA and protein were detected by reverse transcription-polymerase chain reaction and immunohistochemical analysis in the primary and metastasis lesions. Serum calcium and PTHrP levels returned to normal after antihypercalcemic treatment and a radical operation, but they elevated along with the recurrence. Because tumor markers such as carcinoembryonic antigen, carbohydrate antigen (CA)125 and CA19-9 were unstable owing to the patient's liver cirrhosis and were not reliable data for management, serum calcium and PTHrP levels are shown to have been a potential indicator of the recurrence in this case.

DOI： 10.1111/j.1447-0756.2006.00358.x

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Circulating angiogenic factors in preeclampsia, gestational proteinuria, and preeclampsia superimposed on chronic glomerulonephritis

H Masuyama, N Suwaki, H Nakatsukasa, A Masumoto, Y Tateishi, Y Hiramatrsu

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY 194 ( 2 ) 551 - 556 2006.2

Language：English Publisher：MOSBY, INC

Objective: Recently, reports have indicated that the imbalance of circulating angiogenic factors is important in the onset of preeclampsia. In this study we investigated angiogenic factor levels in women with preeclampsia, preeclampsia superimposed on chronic glomerulonephritis, gestational proteinuria, and normal pregnancies.
Study design: We measured several circulating angiogenic factors, placental growth factor, vascular endothelial growth factor, soluble fins-like tyrosine kinase-1, and soluble fetal liver kinase-1.
Results: Compared with women with normal pregnancies, placental growth factor concentrations were lower, and soluble fins-like tyrosine kinase 1 concentrations were higher in women with preeclampsia and gestational proteinuria; soluble fms-like tyrosine kinase I concentrations were also higher in women with preeclampsia superimposed on chronic glomerulonephritis.
Conclusion: There were obvious differences in the levels of circulating angiogenic factors placental growth factor and soluble fms-like tyrosine kinase I among preeclampsia, gestational proteinuria, and controls. The imbalance of angiogenic factors is important in the onset of preeclampsia superimposed on chronic glomerulonephritis. (c) 2006 Mosby, Inc. All rights reserved.

DOI： 10.1016/j.ajog.2005.08.034

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Ubiquitin/Proteasome経路を介した核内受容体turnoverにおけるSuppressor for Gal-1の役割

増山寿

岡山医誌 117 ( 3 ) 205 - 209 2006

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