Faculty Profiles - MASUYAMA Hisashi

Leptin, one of adipocytokines, plays a wide range of important roles in reproductive biology. We have previously reported that low hypo-adiponectinemia might be involved in the pathophysiology of overweight preeclampsia (PE) patients. Moreover, recent reports have underscored the importance of circulating angiogenic factors in the pathophysiology of PE. Here, we examined whether leptin in conjunction with adiponectin and/or angiogenic factors plays some role in the pathophysiology of PE. We performed a cross-sectional study in 34 PE patients and normal pregnancies matched for gestational age and body mass index as controls. We measured serum concentrations of leptin, adiponectin, the angiogenic factors vascular endothelial growth factor (VEGF), placental growth factor, and the soluble VEGF receptors sFlt-1 and sFlk-1. We observed that leptin levels in PE patients were significantly higher compared with those in controls, but did not observe significant differences between normal- and overweight patients in both groups. We also showed a significant negative correlation between leptin and adiponectin in controls, but not in PE patients. There was a significant correlation between leptin and sFlt-1 in PE patients, while there were significant differences of body mass index, mean blood pressure and proteinuria between high and low leptin/sFlt-1 ratio group in PE patients. Moreover, there was a significant difference of leptin level between IUGR and normal growth group in PE patients. These results suggest that the circulating increased leptin might be derived mainly from the placenta and regulated by the placental hypoxic condition, whereas adiponectin might be derived mainly from adipose tissue; and that leptin might play some role through insulin resistance, autonomic activation, or direct effect on endothelium with other angiogenic factors in pathophysiology of PE compared with the exaggerated release of adiponectin from adipose tissue.

DOI： 10.1507/endocrj.K07E-136

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A case of fetal chyrothorax treated with thoracocentesis before delivery

75 ( 4 ) 493 - 497 2008

微弱陣痛.

増山寿, 平松祐司, 難波道子, 松井たみこ

ペリネイタルケア 27 ( 12 ) 1174 - 1178 2008

巨大子宮頸部筋腫.

平松祐司, 守屋聡子, 増山寿, 関典子

産婦人科手術 ( 19 ) 33 - 39 2008

産婦人科手術における保険請求.

落合和彦, 礒西成治, 平松祐司, 三橋直樹, 福地剛, 正岡直樹, 増山寿, 寺尾泰久

産婦人科手術 ( 19 ) 141 - 144 2008

心内膜床欠損症.

住田由美, 笠原真悟, 大月審一, 増山寿, 平松祐司

周産期医学 38 ( 11 ) 1383 - 1387 2008

微弱陣痛

増山寿, 平松祐司, 難波道子, 松井たみこ

ペリネイタルケア 27 ( 12 ) 1174 - 1178 2008

肥満女性の栄養代謝学的問題点とその管理妊娠、産褥期：肥満妊婦preeclampsia発症へのadipocytokineの関与.

増山寿, 中務日出輝, 平松祐司

産婦人科の実際 57 ( 8 ) 1225 - 1231 2008

耐糖能異常やpreeclampsiaでのアディポサイトカインの動態と発症への関与

洲脇尚子, 舛本明生, 住田由美, 高本憲男, 増山寿, 平松祐司

糖尿病と妊娠 8 43 - 48 2008

Relation between neonatal jaundice and oncostatin M, hepatocyte growth factor and soluble gp130 levels in umbilical cord

Hideki Nakatsukasa, Hisashi Masuyama, Yoichiro Akahori, Seiji Inoue, Akio Masumoto, Yuji Hiramatsu

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA 87 ( 12 ) 1322 - 1328 2008

Language：English Publisher：TAYLOR & FRANCIS AS

Objectives. Oncostatin M (OSM), hepatocyte growth factor (HGF) and soluble glycoprotein 130 (sgp130) have been demonstrated to be involved in fetal liver development. In this study, we examined the relation between neonatal jaundice and OSM, gp130 or HGF levels in umbilical cord blood. Design. A cross-sectional study of 160 neonates born at Okayama University Hospital. Setting. Tertiary referral center serving a population of three million. Methods. The serum concentrations of OSM, HGF and sgp130 in umbilical venous cord blood were measured and compared with the clinical records of these neonates. Results. The HGF level was correlated to both gestational week (p=0.007) and birthweight (p=0.015), as well as to total bilirubin on Day 1 (p=0.032). In preterm neonates, the HGF levels were lower in neonates who received phototherapy (photo group) than in those who did not receive phototherapy (non-photo group) (p=0.002). In contrast, in term neonates, OSM levels were lower in the photo group than in the non-photo group (p=0.0003). Conclusions. These findings suggest that the phototherapy requirement for neonatal jaundice may be associated with lower umbilical HGF concentration in preterm neonates and with lower umbilical OSM concentration in term neonates.

DOI： 10.1080/00016340802468332

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ワークショップ3「分娩時大量出血への対応」当科で経験したUAE後に妊娠に至った症例についての検討.

瀬川友功, 赤堀洋一郎, 井上誠司, 中務日出輝, 舛本明生, 住田由美, 増山寿, 平松祐司

日本周産期・新生児医学会雑誌 44 ( 4 ) 987 - 991 2008

K2-2 新規インスリン感受性調節因子CNTF (ciliary neurotroohic factor)と妊娠中のインスリン抵抗性,特に妊娠高血圧症候群との関連(優秀演題賞候補演題1,高得点プログラム,第60回日本産科婦人科学会学術講演会)

赤堀洋一郎, 高本憲男, 中務日出揮, 井上誠司, 舛本明生, 増山寿, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 599 - 599 2008

P2-119 妊娠中におけるRetinol binding protein 4(RBP4)とインスリン抵抗性との関連性についての検討(Group48 合併症妊娠2,一般講演,第60回日本産科婦人科学会学術講演会)

井上誠司, 高本憲男, 赤堀洋一郎, 中務日出輝, 舛本明生, 住田由美, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 653 - 653 2008

P2-64 肥満妊婦のpreeclampsia発症へのadipocytokineの関与(Group 42 妊娠・分娩・産褥の生理5,一般講演,第60回産科婦人科学会学術講演会)

増山寿, 中務日出輝, 高木憲男, 平松祐司

日本産科婦人科學會雜誌 60 ( 2 ) 635 - 635 2008

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