Faculty Profiles - MASUYAMA Hisashi

MISC - MASUYAMA Hisashi

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腹腔鏡補助下に診断・治療を行った、高度肥満合併Meigs症候群の一例.

久保光太郎, 楠本知行, 西田傑, 長谷川徹, 春間朋子, 小川千加子, 中村圭一郎, 関典子, 増山寿, 平松祐司

現代産婦人科 63 ( 2 ) 361 - 365 2015

照射野内再発にIMRT(intensity-modulated radiation therapy)が著効した子宮頸癌の一例.

小川千加子, 呉隆進, 早田裕, 西田傑, 春間朋子, 楠本知行, 中村圭一郎, 関典子, 増山寿, 平松祐司

現代産婦人科 63 ( 2 ) 373 - 378 2015

胎児心拍数モニタリング.

増山寿, 平松祐司

週刊日本医事新報 ( 4733 ) 49 - 49 2015

DOHaD説.

増山寿, 平松祐司

週刊日本医事新報 ( 4735 ) 51 - 51 2015

Different fetal and neonatal growth between early- and late-onset preeclampsia.

Mitsui T, Masuyama H, Eto E, Nobumoto E, Hayata K, Hiramatsu Y

Open Journal of Obstetrics and Gynecology 5 ( 9 ) 516 - 521 2015

GDMに対するSMBGの保険適応拡大に向けて.

平野友美加, 光井崇, 渋川昇平, 衛藤英理子, 延本悦子, 早田桂, 瀬川友功, 増山寿, 平松祐司

糖尿病と妊娠 15 ( 1 ) 76 - 76 2015

Pretreatment platelet-lymphocyte ratio is an independent predictor of cervical cancer recurrence following concurrent chemoradiation therapy. International journal

Keiichiro Nakamura, Takeshi Nishida, Tomoko Haruma, Junko Haraga, Chiaki Omichi, Chikako Ogawa, Tomoyuki Kusumoto, Noriko Seki, Hisashi Masuyama, Yuji Hiramatsu

Molecular and clinical oncology 3 ( 5 ) 1001 - 1006 2015

Language：English Publisher：SPANDIDOS PUBL LTD

The aim of the present study was to identify the correlations between inflammation markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and C-reactive protein (CRP) and the prognosis in patients with recurrent cervical cancer. The associations among NLR, PLR and CRP and clinical characteristics and prognosis were examined in 32 patients receiving chemotherapy with recurrent cervical cancer following concurrent chemoradiation therapy (CCRT). The patient median survival time was 198 days (range, 42-1,022 days). Pretreatment NLR and PLR were significantly correlated with the recurrence of cervical cancer following CCRT (R=-0.538, P=0.002; and R=-0.542, P=0.001, respectively). Pretreatment PLR >322.0 was significantly associated with a poor prognosis for recurrent cervical cancer following CCRT by univariate and multivariate analyses (P=0.015 and P=0.029). These findings indicate that pretreatment PLR is an important predictor of prognosis in patients with recurrent cervical cancer following CCRT.

DOI： 10.3892/mco.2015.595

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P3-35-6 妊娠17週にて子宮破裂を発症した既往帝王切開後妊娠の1例(Group137 子宮破裂 TOLAC,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

光井崇, 西田傑, 中村圭一郎, 早田桂, 谷和祐, 河原義文, 衛藤英理子, 延本悦子, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 907 - 907 2015

P1-33-8 妊娠中に顕在化した緩徐進行1型糖尿病の1例(Group33 合併症妊娠4,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

清時毅典, 延本悦子, 光井崇, 衛藤英理子, 早田桂, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 622 - 622 2015

P2-58-1 18トリソミーに特徴的な小脳低形成検出を目的とした,小脳横径と小脳半球縦径の基準値作成と臨床応用(Group 99 胎児異常1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

早田桂, 渋川昇平, 光井崇, 平野友美加, 衛藤英理子, 延本悦子, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 805 - 805 2015

P2-30-7 先天性アンチトロンビン3欠損症合併妊娠の2症例(Group 71 不育症臨床,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

甲斐憲治, 酒本あい, 長谷川徹, 久保光太郎, 松田美和, 小谷早葉子, 瀬川友功, 鎌田泰彦, 増山寿, 中塚幹也, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 726 - 726 2015

P2-24-2 手術前に画像診断し得た静脈内子宮平滑筋腫の一例(Group 65 良性・悪性腫瘍症例1,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

兼森美帆, 中村圭一郎, 西田傑, 春間朋子, 小川千加子, 楠本知行, 関典子, 増山寿, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 711 - 711 2015

P2-4-10 子宮頸癌再発のplatelet-to-lymphocyte ratio (PLR)は予後予測に有効である(Group45 子宮頸部腫瘍症例検討,一般演題,公益社団法人日本産科婦人科学会第67回学術講演会)

中村圭一郎, 西田傑, 春間朋子, 小川千加子, 楠本知行, 関典子, 増山寿, 平松祐司

日本産科婦人科學會雜誌 67 ( 2 ) 659 - 659 2015

先天性サイトメガロウイルス感染症の2例

玉田祥子, 牧尉太, 江口武志, 光井崇, 平野友美加, 衛藤英理子, 延本悦子, 早田桂, 増山寿, 平松祐司

日本絨毛性疾患研究会・日本胎盤学会学術集会プログラム・抄録集 33rd-23rd 2015

Efficacy of transarterial embolisation in the management of post-partum haemorrhage and its impact on subsequent pregnancies

Seiji Inoue, Hisashi Masuyama, Yuji Hiramatsu

AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY 54 ( 6 ) 541 - 545 2014.12

Language：English Publisher：WILEY-BLACKWELL

BackgroundTransarterial embolisation (TAE) has been attracting attention as a treatment option for post-partum haemorrhage (PPH).
AimsWe investigated cases in which TAE was performed for PPH to determine the efficacy of TAE for the treatment of PPH and its impact on subsequent pregnancies and childbirth in a multi-institutional case-series study.
Materials and MethodsA total of 211 women who underwent emergency (n=161) or prophylactic (n=50) TAE for the management of PPH from 2002 to 2011 in the Chugoku and Shikoku regions of Japan were evaluated. Data on maternal background, treatment efficacy, adverse events in 113 cases followed up after TAE and subsequent pregnancies in 76 women were obtained.
ResultsThe overall success rate of emergency and prophylactic TAE was 91.9 and 96.0%, respectively. The rate of complications such as infection, uterine necrosis and amenorrhoea was 13.3% among women followed up after TAE. Forty women became pregnant after TAE, and the pregnancy rate among those who desired fertility was 52.6%. Twenty-eight gave birth, including four preterm deliveries. Five (16.7%) were associated with a hysterectomy due to placenta accreta.
ConclusionsTo reduce haemorrhage and avoid hysterectomy, TAE may be considered as a treatment option for PPH, however short and long terms complications are not uncommon.

DOI： 10.1111/ajo.12228

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The inhibition of constitutive androstane receptor-mediated pathway enhances the effects of anticancer agents in ovarian cancer cells

Yan Wang, Hisashi Masuyama, Etsuko Nobumoto, Guangmei Zhang, Yuji Hiramatsu

BIOCHEMICAL PHARMACOLOGY 90 ( 4 ) 356 - 366 2014.8

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Background: Ovarian cancer is commonly treated with anticancer agents; however, many tumors become resistant. Resistance is regulated, in part, by P-glycoprotein, which is encoded by the gene multiple drug resistance 1 (MDR1) and functions as a transmembrane efflux pump for the elimination of anticancer agents. Constitutive androstane receptor (CAR) is a nuclear receptor that regulates drug metabolism through control of MDR1 and other genes.
Purpose: We examined whether the inhibition of CAR-mediated pathway could influence the cytotoxicity of three anticancer drugs, cisplatin, paclitaxel, and arsenic trioxide, in ovarian cancer cells.
Results: We observed that the cell proliferation of several ovarian cell lines expressing CAR significantly increased when CITCO was combined with anticancer agents compared with any anticancer agent alone. The up-regulation of MDR1 and UGT1A1 by anticancer agents was further enhanced in the presence of CITCO. We confirmed that combining CITCO with anticancer agents induced significantly lower levels of apoptosis than those achieved with any single anticancer drug. CAR down-regulation by RNA interference caused a significant increase in cell growth inhibition and enhancement of apoptosis in the presence of anticancer agents. Combination of CITCO with any anticancer agents significantly enhanced CAR-mediated transcription compared with any anticancer agents alone and CAR down-regulation completely inhibited the transcription in the presence of CITCO and/or anticancer agents.
Conclusion: Inhibition of CAR pathway could be a novel therapeutic approach for the augmentation of sensitivity to anticancer agents, or to overcome resistance, in the treatment of ovarian cancer. (C) 2014 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bcp.2014.06.003

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Additive Effects of Maternal High Fat Diet during Lactation on Mouse Offspring

Hisashi Masuyama, Yuji Hiramatsu

PLOS ONE 9 ( 3 ) e92805-e92805 2014.3

Language：English Publisher：PUBLIC LIBRARY SCIENCE

Recent reports indicated that nutrition in early infancy might influence later child health outcomes such as obesity and metabolic syndrome. Therefore, we examined the effects of maternal high fat diet (HFD) during lactation on the onset of a metabolic syndrome in their offspring. All offspring were cross-fostered by dams on the same or opposite diet to yield 4 groups: offspring from HFD-fed dams suckled by HFD-fed dams (OHH) and by control diet (CD)-fed dams (OHC) and CD-fed dams suckled by HFD-fed dams (OCH) and by CD-fed dams (OCC) mice. We examined several metabolic syndrome-related factors including body weight, blood pressure, glucose tolerance and adipocytokines. Mean body weights of OHH and OCH mice were significantly higher than those of OHC and OCC mice, respectively, with elevated systolic blood pressure. Moreover, OHH and OCH mice revealed significantly worse glucose tolerance compared with the OHC and OCC mice, respectively. Triglyceride and leptin levels were significantly increased and adiponectin levels were significantly reduced by the maternal HFD during lactation, with similar changes in leptin and adiponectin mRNA expression but without histone modifications in adipose tissues. In addition, maternal obesity induced by HFD during lactation increased and prolonged the leptin surge in the offspring and the gender differences of leptin surge were observed. Our data suggested that maternal HFD during lactation might have an additive effect on the onset of the metabolic syndrome in the offspring, irrespective of the nutritional status in utero through the modified leptin surge.

DOI： 10.1371/journal.pone.0092805

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成熟嚢胞性奇形腫悪性転化3症例の検討.

尾嶋真由子, 楠本知行, 江口武志, 大道千晶, 乃美志保, 原賀順子, 春間朋子, 小川千加子, 中村圭一郎, 関典子, 増山寿, 平松祐司

現代産婦人科 63 ( 1 ) 159 - 163 2014

開腹手術.

平松祐司, 増山寿, 早田桂, 延本悦子

産婦人科の実際 63 ( 10 ) 1335 - 1341 2014

2．婦人科腫瘍における静脈血栓塞栓症の発症メカニズムとリスク因子.

関典子, 春間朋子, 福島千加子, 楠本知行, 中村圭一郎, 増山寿, 平松祐司

日本婦人科腫瘍学会雑誌 32 ( 2 ) 147 - 153 2014

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