Faculty Profiles - MASUYAMA Hisashi

MISC - MASUYAMA Hisashi

Division display 401 - 420 of about 496 ／ All the affair displays >>

子宮体癌における新しい薬物耐性機構の解明(子宮体部悪性腫瘍IX, 第57回日本産科婦人科学会学術講演会)

増山寿, 中務日出輝, 洲脇尚子, 立石洋子, 瀬川友功, 井下秀司, 水谷靖司, 平松祐司

日本産科婦人科學會雜誌 57 ( 2 ) 607 - 607 2005

潰瘍性大腸炎合併妊娠の検討(合併症妊娠V, 第57回日本産科婦人科学会学術講演会)

松尾環, 井上誠司, 舛本明生, 住田由美, 立石洋子, 井下秀司, 増山寿, 水谷靖司, 平松祐司

日本産科婦人科學會雜誌 57 ( 2 ) 742 - 742 2005

Peroxisome proliferator-activated receptorγ ligand は糖尿病合併妊娠における胎盤機能不全を改善する(合併症妊娠III, 第57回日本産科婦人科学会学術講演会)

洲脇尚子, 増山寿, 舛本明生, 立石洋子, 井下秀司, 水谷靖司, 平松祐司

日本産科婦人科學會雜誌 57 ( 2 ) 737 - 737 2005

糖尿病マウス胎仔での奇形の発生における終末糖化産物 (AGE) の関与(胎児・新生児VIII, 第57回日本産科婦人科学会)

舛本明生, 洲脇尚子, 立石洋子, 井下秀司, 増山寿, 水谷靖司, 平松祐司

日本産科婦人科學會雜誌 57 ( 2 ) 705 - 705 2005

099 低出生体重児を出産した母親への分娩直後の援助(妊娠、分娩、産褥20)(第45回日本母性衛生学会総会学術集会)

大井伸子, 増山寿, 新田明子, 松井たみこ

母性衛生 45 ( 3 ) 127 - 127 2004.9

Involvement of suppressor for Gal 1 in the ubiquitin/proteasome-mediated degradation of estrogen receptors

H Masuyama, Y Hiramatsu

JOURNAL OF BIOLOGICAL CHEMISTRY 279 ( 13 ) 12020 - 12026 2004.3

Language：English Publisher：AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

The proteasome-mediated pathway involves the degradation of several nuclear receptors. Previously we demonstrated that the interaction between the suppressor for Gal 1 (SUG1) and nuclear receptors, the vitamin D receptor, or the pregnane X receptor was involved in proteasome-mediated degradation. In our recent experiments, we examined the potential role of SUG1 in the proteasome-mediated degradation of estrogen receptors (ER)alpha and - beta. Both ERs interacted with SUG1 in a ligand-dependent manner. Functionally, the overexpression of SUG1 inhibited both ERalpha- and ERbeta-mediated transcription in the presence of ligands. Transient expression studies demonstrated that the overexpression of wildtype SUG1 generated proteolytic fragments of both ERs and that these products were blocked by a proteasome inhibitor. The overexpression of SUG1 also enhanced the formation of ubiquitinated proteins of both ERs in the presence of ligand. On the other hand, bisphenol A (BSA), which activated ER-mediated transcription, did not enhance the interaction between ERbeta and SUG1. Furthermore, the degradation of ERbeta was much slower in the presence of BSA than in the presence of estradiol or phthalate, which is another endocrine-disrupting chemical. Also, BSA had no effect on the formation of proteolytic fragments of ERbeta, and neither did it have any effect on the ubiquitination of ERbeta. These findings indicate that the ubiquitin/proteasome-mediated degradation of both ER proteins may involve the interaction of SUG1 with both ERs. Moreover, BSA strongly blocked the ubiquitination and degradation of ERbeta compared with estradiol, suggesting that BSA may affect the ERbeta-mediated transcription of target genes by inhibiting ERbeta degradation.

DOI： 10.1074/jbc.M312762200

Web of Science

researchmap

Proteasomeを介した核内受容体turnoverとsuppressor for gal-1(SUG1).

増山寿, 井下秀司, 瀬川友功, 洲脇尚子, 水谷靖司, 平松祐司

日本産科婦人科栄養・代謝研究会誌 2004

特発性血小板減少性紫斑病（ITP）合併妊娠

平松祐司, 洲脇尚子, 増山寿

産婦人科の実際 53,9,1349-1358 2004

＜林原賞受賞講演＞Expression and Potential Roles of Pregnane X Receptor in Endometrial Cancer.

増山寿

岡山医学会雑誌 116,,191 2004