Faculty Profiles - MASUYAMA Hisashi

MISC - MASUYAMA Hisashi

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統合失調症合併妊娠の周産期管理とその問題点.

乃美志保, 井上誠司, 江口武志, 大道千晶, 尾嶋真由子, 原賀順子, 延本悦子, 沖本直輝, 瀬川友功, 増山寿, 平松祐司

現代産婦人科 61 ( 2 ) 201 - 204 2013

当院における緊急産褥搬送の現状.

井上誠司, 延本悦子, 早田桂, 沖本直輝, 瀬川友功, 増山寿, 平松祐司

現代産婦人科 61 ( 2 ) 223 - 226 2013

Language：Japanese Publisher：中国四国産科婦人科学会

産褥期の緊急搬送は、妊娠中の母体搬送と比較し頻度は低いものの、とくに出産直後に生じる急性疾患は迅速な診断と治療が要求され、対応が遅れると母体死亡にいたる危険をはらんでいるが、逆に適切な処置により早期の回復が期待できる。今回われわれは、当科における緊急産褥搬送の現状について調査・検討を行った。2007年1月〜2012年6月において、当科に産褥期に緊急搬送された52症例を対象とし、その病態・入院時所見・治療内容について後方視的検討を行った。産褥搬送症例の内訳は、出血性疾患42例(弛緩出血13例、外陰腟壁血腫10例、癒着胎盤・胎盤遺残8例、頸管・腟壁裂傷4例、子宮破裂3例、子宮内反症2例、その他2例)および非出血性疾患10例であった。出血性疾患において入院時平均ヘモグロビン値は8.7g/dl(1.4-13.6)、推定総出血量2,657ml(130-15,000)、shock index 1.0以上であったのは13例(32%)であった。そのうち輸血は24例(57.1%)、外科的処置は22例(52.4%)、子宮動脈塞栓術は9例(21.4%)に施行された。緊急産褥搬送された症例は、高率に輸血や外科的介入を要するため、個々の症例の病態や重症度に応じて、迅速に評価・判断を行い適切な治療を行う必要がある。母体救命のためには、前医および関連各科との円滑な連携体制、迅速な血液製剤輸血の準備、手術室の整備が必須であると考えられた。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2013&ichushi_jid=J05038&link_issn=&doc_id=20130620480015&doc_link_id=%2Fcv0mtrob%2F2012%2F006102%2F015%2F0223-0226%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fcv0mtrob%2F2012%2F006102%2F015%2F0223-0226%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

卵管妊娠破裂/頸管妊娠出血.

増山寿, 平松祐司

臨床婦人科産科産婦人科当直医マニュアル慌てないための虎の巻 67 ( 4(増刊号) ) 28 - 31 2013

最近の周術期管理について.

寺尾泰久, 増山寿, 藤井多久磨, 正岡直樹, 平松祐司, 小西郁生

産婦人科手術 ( 24 ) 111 - 115 2013

糖尿病と胎盤.

増山寿, 舛本明生, 洲脇尚子, 平松祐司

産婦人科の実際 62 ( 8 ) 1073 - 1078 2013

妊婦の悩みに応じられる助産師になろうビジュアルで学ぶマイナートラブル解決法 5．つわり.

増山寿, 平松祐司

ペリネイタルケア 32 ( 12 ) 27 - 30 2013

2生児を出産した妊娠許可基準を満たさない慢性腎不全合併妊娠の1例.

江口武志, 大道千晶, 尾嶋真由子, 乃美志保, 原賀順子, 沖本直輝, 延本悦子, 井上誠司, 瀬川友功, 増山寿, 平松祐司

現代産婦人科 62 ( 1 ) 133 - 137 2013

K2-7-3 高脂肪食飼育子宮内環境は,アディポサイトカイン遺伝子のエピゲノム変化を介して世代を超えてメタボリック症候群発症に関与する(高得点演題12 周産期医学3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

増山寿, 延本悦子, 沖本直輝, 早田桂, 井上誠司, 瀬川友功, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 693 - 693 2013

P2-30-9 若年卵巣がん妊孕能温存手術後妊娠出産例の検討(Group 82 合併症妊娠4,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

関典子, 増山寿, 福島千加子, 楠本知行, 中村圭一郎, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 782 - 782 2013

P2-35-4 先天性心疾患胎児における脳血流動態および頭部発育についての検討(Group 87 胎児奇形・先天異常3,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

沖本直輝, 延本悦子, 井上誠司, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 794 - 794 2013

P1-37-8 精神科入院を要した統合失調症合併妊娠の周産期臨床像(Group 37 合併症妊娠2,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

乃美志保, 井上誠司, 延本悦子, 沖本直輝, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 635 - 635 2013

P3-28-5 低体温療法が有効であった臍帯真結節による重症新生児仮死の一例(Group 133 胎盤・羊水(症例)1,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

河合清日, 増山寿, 延本悦子, 沖本直輝, 井上誠司, 瀬川友功, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 939 - 939 2013

P3-26-7 当科における前置胎盤の臨床的検討(Group 131 胎盤2,一般演題,公益社団法人日本産科婦人科学会第65回学術講演会)

丹羽家泰, 延本悦子, 沖本直輝, 井上誠司, 瀬川友功, 増山寿, 平松祐司

日本産科婦人科學會雜誌 65 ( 2 ) 933 - 933 2013

Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice

Hisashi Masuyama, Yuji Hiramatsu

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 303 ( 2 ) E293 - E300 2012.7

Language：English Publisher：AMER PHYSIOLOGICAL SOC

Masuyama H, Hiramatsu Y. Treatment with constitutive androstane receptor ligand during pregnancy prevents insulin resistance in offspring from high-fat diet-induced obese pregnant mice. Am J Physiol Endocrinol Metab 303: E293-E300, 2012. First published May 29, 2012; doi:10.1152/ajpendo.00167.2012.-The constitutive androstane receptor (CAR) has been reported to decrease insulin resistance even during pregnancy, while exposure to a high-fat diet (HFD) in utero in mice can induce a type 2 diabetes phenotype that can be transmitted to the progeny. Therefore, we examined whether treatment with a CAR ligand during pregnancy could prevent hypertension, insulin resistance, and hyperlipidemia in the offspring from HFD-induced obese pregnant mice (OH mice). We employed four groups of offspring from HFD-fed and control diet-fed pregnant mice with or without treatment with a CAR ligand. Treatment with a CAR ligand during pregnancy improved glucose tolerance and the levels of triglyceride and adipocytokine and restored the changes induced by HFD with amelioration of hypertension in the adult OH mice. This treatment also increased adiponectin mRNA expression, suppressed leptin expression in adipose tissues of OH mice, and abolished the effect of HFD on the epigenetic modifications of the genes encoding adiponectin and leptin in the offspring during immaturity and adulthood. Our data suggest that CAR might be a potential therapeutic target to prevent metabolic syndrome in adulthood of offspring exposed to an HFD in utero.

DOI： 10.1152/ajpendo.00167.2012

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Effects of a High-Fat Diet Exposure in Utero on the Metabolic Syndrome-Like Phenomenon in Mouse Offspring through Epigenetic Changes in Adipocytokine Gene Expression

Hisashi Masuyama, Yuji Hiramatsu

ENDOCRINOLOGY 153 ( 6 ) 2823 - 2830 2012.6

Language：English Publisher：ENDOCRINE SOC

The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. Adipocytokines such as leptin and adiponectin play important roles in glucose and lipid metabolism. Therefore, we examined whether the offspring from dams exposed to a high-fat diet during pregnancy (OH mice) exhibited hypertension, insulin resistance, and hyperlipidemia along with epigenetic changes in the expression of adipocytokine genes. OH mice were significantly heavier than the offspring of dams exposed to a control diet during pregnancy (OC mice) from 14 wk of age after an increased caloric intake from 8 wk. OH mice exhibited higher blood pressure and worse glucose tolerance than the OC mice at 24 wk. Total triglyceride and leptin levels were significantly higher and the adiponectin level was significantly lower in OH compared with OC mice at 12 wk of age. This was associated with changes in leptin and adiponectin expression in white adipose tissue. There were lower acetylation and higher methylation levels of histone H3 at lysine 9 of the promoter of adiponectin in adipose tissues of OH mice at 2 wk of age as well as at 12 and 24 wk of age compared with OC mice. In contrast, methylation of histone 4 at lysine 20 in the leptin promoter was significantly higher in OH compared with OC mice. Thus, exposure to a high-fat diet in utero might cause a metabolic syndrome-like phenomenon through epigenetic modifications of adipocytokine, adiponectin, and leptin gene expression. (Endocrinology 153: 2823-2830, 2012)

DOI： 10.1210/en.2011-2161

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Severe Superimposed Preeclampsia with Obesity, Diabetes and a Mild Imbalance of Angiogenic Factors

Hisashi Masuyama, Etsuko Nobumoto, Tomonori Segawa, Yuji Hiramatsu

ACTA MEDICA OKAYAMA 66 ( 2 ) 171 - 175 2012.4

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity, diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.

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A case of a pregnant woman expected to be infected with syphilis during pregnancy

MURAKAMI Yuko, INOUE Seiji, SAITO Masako, NOBUMOTO Etsuko, OKIMOTO Naoki, SEGAWA Tomonori, MASUYAMA Hisashi, HIRAMATSU Yuji, FUJIWARA Michihisa

60 ( 2 ) 341 - 344 2012.3

A case of twin pregnancy complicated with intrauterine fetal death caused by colon cancer

SAITO Masako, INOUE Seiji, KUBO Kotaro, KUROKAWA Haruna, NISHIDA Takeshi, HASEGAWA Toru, MITSUI Takashi, NOBUMOTO Etsuko, OKIMOTO Naoki, SEGAWA Tomonori, MASUYAMA Hisashi, HIRAMATSU Yuji

60 ( 2 ) 219 - 224 2012.3

Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia

Hisashi Masuyama, Etsuko Nobumoto, Seiji Inoue, Yuji Hiramatsu

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 302 ( 6 ) E687 - E693 2012.3

Language：English Publisher：AMER PHYSIOLOGICAL SOC

Masuyama H, Nobumoto E, Inoue S, Hiramatsu Y. Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia. Am J Physiol Endocrinol Metab 302: E687-E693, 2012. First published January 10, 2012; doi:10.1152/ajpendo.00548.2011.-Adiponectin was reported recently to have roles in the pathophysiology of preeclampsia. Moreover, elevation of adiponectin and brain natriuretic peptide (BNP) has been observed in preeclampsia. We examined the possible links between adiponectin and BNP in the pathophysiology of preeclampsia. We performed a cross-sectional study in 56 preeclampsia patients and 56 controls matched for gestational age and body mass index. The BNP, leptin, and adiponectin levels were measured by ELISA, and their mRNA expressions were evaluated in omental adipose tissue by real-time PCR. The effects of BNP on adiponectin and leptin mRNA expression and secretion were investigated in primary cultures of adipocytes from obese and normal-weight women. The BNP, adiponectin, and leptin levels were significantly higher in preeclampsia patients compared with controls. The adiponectin level was increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients. Adiponectin mRNA expression was increased significantly in adipose tissues of preeclampsia patients compared with controls and was also increased significantly in normal-weight preeclampsia patients compared with overweight preeclampsia patients, whereas leptin was not. BNP and adiponectin showed significant positive correlations in both normal-weight and overweight preeclampsia patients. BNP had a significantly weaker effect on adiponectin in overweight compared with normal-weight preeclampsia patients. Moreover, BNP had a weaker effect on adiponectin production in adipocytes from overweight women compared with adipocytes from normal-weight women using primary culture of human adipocytes. These data suggested that BNP may play a role in hyperadiponectinemia of preeclampsia patients. The weaker effect of BNP on adiponectin production may participate in the pathophysiology of overweight preeclampsia patients.

DOI： 10.1152/ajpendo.00548.2011

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Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice

H. Masuyama, Y. Hiramatsu

MOLECULAR AND CELLULAR ENDOCRINOLOGY 348 ( 1 ) 120 - 127 2012.1

Language：English Publisher：ELSEVIER IRELAND LTD

Constitutive androstane receptor (CAR) has been reported to decrease insulin resistance, while obesity and insulin resistance may also be involved in the pathogenesis of preeclampsia. We examined whether a CAR ligand, 1,4-bis(2-(3,5-dichloropyridyloxy)) benzene (TCPOBOP), can ameliorate the signs of preeclampsia in high-fat diet (HFD)-induced obese pregnant mice to examine a possibility of CAR as a therapeutic target. We employed six groups including non-pregnant, NED-fed or control diet-fed pregnant mice with or without TCPOBOP treatment (n = 6). In HFD pregnant mice, insulin resistance increased with increasing expression of gluconeogenic and lipogenic genes and abnormal adipocytokine levels. TCPOBOP treatment, which was once-weekly intraperitoneal injections (0.5 mg/kg) and started at day 0.5 of pregnancy, improved glucose tolerance with significant changes of gluconeogenic, lipogenic and adipocytokine genes. HFD pregnant mice had hypertension and proteinuria, while TCPOBOP treatment ameliorated these signs. Our data suggested CAR might be a potential therapeutic target for obese preeclampsia patients with insulin resistance. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.mce.2011.07.047

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