Faculty Profiles - NAKATSUKA Mikiya

MISC - NAKATSUKA Mikiya

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新連載：助産師・看護師に知ってほしいLGBTの基礎知識「LGBT，トランスジェンダーって何？」

中塚幹也

臨床助産ケア 10 ( 3 ) 82 - 85 2018

配偶子保存の必要性と課題：配偶子凍結に伴う倫理的問題

中塚幹也

臨床婦人科産科 72 ( 5 ) 424 - 428 2018

連載第26回：不育症の基礎知識と患者支援のポイント「不育症女性の職場でのストレス」

中塚幹也

臨床助産ケア 10 ( 1 ) 93 - 96 2018

性同一性障害（FTM）の診断と対応

中塚幹也

ホルモンと臨床 63 ( 6 ) 493 - 498 2018

特集：LGBTを学ぶ LGBTの基礎知識

中塚幹也

健康教室 69 ( 1 ) 22 - 24 2018

性同一性障害当事者と家族形成

中塚幹也

日本母性衛生学会 58 ( 4 ) 学3-学8 2018

胚培養士が行う不妊予防啓発授業

高山修, 大月純子, 舟橋弘晃, 舟橋弘晃, 中塚幹也, 中塚幹也

日本不妊カウンセリング学会誌 17 ( 1 ) 2018

教職員における性別違和感を持つ児童生徒に対する意識調査学校内での啓発方法

林田桃子, 樫野千明, 藤田志保, 新井富士美, 中塚幹也

GID(性同一性障害)学会雑誌 10 ( 1 ) 106 - 106 2017.12

High Expression of High-Mobility Group Box 1 in Menstrual Blood: Implications for Endometriosis

Keiko Shimizu, Yasuhiko Kamada, Ai Sakamoto, Miwa Matsuda, Mikiya Nakatsuka, Yuji Hiramatsu

REPRODUCTIVE SCIENCES 24 ( 11 ) 1532 - 1537 2017.11

Language：English Publisher：SAGE PUBLICATIONS INC

Endometriosis is a benign gynecologic disease characterized by the presence of ectopic endometrium and associated with inflammation and immune abnormalities. However, the molecular basis for endometriosis is not well understood. To address this issue, the present study examined the expression of high-mobility group box (HMGB) 1 in menstrual blood to investigate its role in the ectopic growth of human endometriotic stromal cells (ESCs). A total of 139 patients were enrolled in this study; 84 had endometriosis and 55 were nonendometriotic gynecological patients (control). The HMGB1 levels in various fluids were measured by enzyme-linked immunosorbent assay. Expression of receptor for advanced glycation end products (RAGE) in eutopic and ectopic endometrium was assessed by immunohistochemistry, and RAGE and vascular endothelial growth factor (VEGF) messenger RNA expression in HMGB1- and lipopolysaccharide (LPS)-treated ESCs was evaluated by real-time polymerase chain reaction. The HMGB1 concentration was higher in menstrual blood than in serum or peritoneal fluid (P < .001 for both). RAGE was expressed in both normal and ectopic endometrium. Administration of 1000 ng/mL HMGB1 or coadministration of 100 ng/mL HMGB1 and 100 ng/mL LPS induced VEGF production in ESCs relative to the control (P < .05). These results suggest that menstrual fluid has naturally high levels of HMGB1 and may promote endometriosis following retrograde menstruation when complexed with other factors such as LPS by inducing inflammation and angiogenesis.

DOI： 10.1177/1933719117692042

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white plus いま、女性医療の領域で起きている注目すべき変化平成27年4月文部科学省通知「性同一性障害に係る児童生徒に対するきめ細かな対応の実施等」の実際について

中塚幹也

これからの女性医療を考えるWhite 5 ( 1 ) 50 - 53 2017

悪性腫瘍等の治療に関与する医療スタッフにおける生殖機能温存についての意識と対応の実態

宮本志織, 片岡久美恵, 中塚幹也

日本不妊カウンセリング学会誌 16 ( 1 ) 56 - 57 2017

性同一性障害の基礎知識

中塚幹也

日母性衛生学会学9-学17 2017

＜特集Ⅰ＞第35回日本思春期学会総会学術集会教育講演6 思春期における性同一性障害診療の課題：学校と医療施設との連携

中塚幹也

思春期学 35 ( 1 ) 31 - 36 2017

連載第22回：不育症の基礎知識と患者支援のポイント「Tender Loving Careの効果」

中塚幹也

臨床助産ケア 9 ( 2 ) 95 - 97 2017

性同一性障害（GID）とテストステロン

久保光太郎, 中塚幹也

最新女性医療 4 ( 1 ) 29 - 33 2017

特集：不妊と薬種々疾患を有する挙児を希望する不妊患者へのアプローチ①統合失調症×女性不妊

中塚幹也

薬局 68 ( 2 ) 324 - 328 2017

連載第21回：不育症の基礎知識と患者支援のポイント「Tender Loving Careの実際」

中塚幹也

臨床助産ケア 9 ( 1 ) 96 - 98 2017

【学習コーナー】性同一性障害の基礎知識外来診療・看護

中塚幹也

母性衛生 58 ( 2 ) 学3-学8 2017

連載第23回：不育症の基礎知識と患者支援のポイント「流産の原因とされること：喫煙など」

中塚幹也

臨床助産ケア 9 ( 3 ) 79 - 83 2017

Increased Anti-HSP60 and Anti-HSP70 Antibodies in Women with Unexplained Recurrent Pregnancy Loss

Miwa Matsuda, Aiko Sasaki, Keiko Shimizu, Yasuhiko Kamada, Soichi Noguchi, Yuji Hiramatsu, Mikiya Nakatsuk

ACTA MEDICA OKAYAMA 71 ( 3 ) 201 - 208 2017

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Vascular dysfunction has been reported in women with recurrent pregnancy loss (RPL). We investigated the severity of vascular dysfunction in non-pregnant women with RPL and its correlation with anti-heat shock protein (HSP) antibodies that are known to induce arteriosclerosis. We measured the serum anti-HSP60 antibodies, anti-HSP70 antibodies, and anti-phospholipid antibodies (APA) in 68 women with RPL and 29 healthy controls. Among the women with RPL, 14 had a diagnosis of antiphospholipid syndrome (APS), and in the remaining 54, the causes for RPL were unexplained. Compared to the controls, the brachial-ankle pulse wave velocity (baPWV), carotid augmentation index (cAI), and uterine artery pulsatility index (PI) were all significantly higher in the women with both APS and unexplained RPL. Compared to the controls, the anti-HSP60 antibody levels were significantly higher in the APA-positive group of women with unexplained RPL, and the anti-HSP70 antibody levels were significantly higher in APS and APA-positive group of women with unexplained RPL. However, the anti-HSP60 and anti-HSP70 antibody levels did not correlate with the values of baPWV or cAI. Our results demonstrated anti-HSP60 and anti-HSP70 antibodies are increased in women with unexplained RPL. Further studies are needed to elucidate the roles of anti-HSP antibodies and their pathophysiology in unexplained RPL.

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