Faculty Profiles - NAKATSUKA Mikiya

Problem
Endometriosis has been proposed to be an autoimmune disease because of the presence of a variety of autoantibodies specific for endometrial or ovarian antigens. The object of the present study is to characterize binding specificity of anti-laminin-111 autoantibodies in infertile patients with endometriosis and to investigate whether these autoantibodies affect the in vitro embryo development.
Method of study
An ELISA analysis using overlapping synthesized peptides that covered the entire G domain of laminin-alpha 1 chain was performed in infertile patients with endometriosis (n = 45). Mouse blastocysts were cultured in media containing the purified IgG from one antibody-positive serum on laminin-111-coated dishes.
Results
Anti-laminin-111 autoantibodies were directed to several particular biologically functional peptide sequences in laminin-alpha 1 chain G domain. The tested IgG significantly inhibited the extent of in vitro trophoblast outgrowth.
Conclusion
Anti-laminin-111 autoantibodies may have major pathogenic roles on early reproductive failure including endometriosis-associated infertility.

DOI： 10.1111/j.1600-0897.2010.00956.x

Web of Science

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Increased arterial stiffness in mildly-hypertensive women with polycystic ovary syndrome

Aiko Sasaki, Yayoi Emi, Miwa Matsuda, Sharula, Yasuhiko Kamada, Chebib Chekir, Yuji Hiramatsu, Mikiya Nakatsuka

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 37 ( 5 ) 402 - 411 2011.5

Language：English Publisher：WILEY-BLACKWELL

Aim:
Although risk factors for cardiovascular disease, such as obesity, hyperinsulinemia, and dyslipidemia, are commonly observed in women with polycystic ovary syndrome (PCOS), impairment of vascular function is still controversial. We evaluated the vascular function in young women with PCOS.
Methods:
We evaluated arterial stiffness in 54 women with PCOS and 24 healthy control women using a volume-plethysmographic apparatus equipped with a multi-element applanation tonometry sensor for the left common carotid artery and studied the correlations of various factors.
Results:
There was no significant difference in age or body mass index between the controls and the women with PCOS. These women with PCOS had a significantly higher serum testosterone and C-reactive protein levels and showed insulin resistance and dyslipidemia. The mean blood pressure in women with PCOS was within the normal range, but still significantly higher than those in the controls. Women with PCOS had a significantly higher brachial-ankle pulse wave velocity (baPWV) than that for the controls (P < 0.02), whereas there was no significant difference in the carotid augmentation index between the two groups. Stepwise multiple regression analysis revealed that blood pressure influences the baPWV in women with PCOS. Arterial stiffness evaluated using the baPWV in mildly-hypertensive women (systolic blood pressure >= 120 mmHg or diastolic blood pressure >= 90 mmHg) with PCOS was significantly higher than that in the controls or normotensive women with PCOS.
Conclusions:
Early changes in vascular function were detected in mildly-hypertensive women with PCOS. Lifestyle interventions to prevent hypertension, such as diet and exercise, should be the first-line of treatment in women with PCOS.

DOI： 10.1111/j.1447-0756.2010.01375.x

Web of Science

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腹腔鏡下手術後の仙骨子宮靭帯上に発生した子宮内膜症性嚢胞の１例

鎌田泰, 菊池由, 淵, 松田美, 小谷早, 水, 楠本, 中塚, 児玉, 平松祐

現代産婦人科 60 ( 1 ) 2011

「飛び込み分娩」における母子の実際

中塚幹也

産婦人科治療 103 ( 4 ) 2011

血栓性素因のある不育症に対するへパリンカルシウム自己皮下注射の安全性についての検討

齋藤滋, 丸山哲夫, 田中忠夫, 竹下俊行, 山田秀人, 小澤伸晃, 中塚幹也, 木村正, 福井淳史, 杉俊隆

日本産婦人科・新生児血液学会誌 21 ( 1 ) 2011

グリーフケアを受けた流死産女性への継続ケアとしての退院後面接の試み

古谷真実, 秦久美子, 殿森恵利子, 難波沙由里, 中塚幹也

日本不妊カウンセリング学会誌 10 ( 1 ) 2011

妊娠中の不育症女性の不安

秦久美子, 久世恵美子, 中塚幹也

日本不妊カウンセリング学会誌 10 ( 1 ) 2011

「妊婦のDV被害」の実態と産科医療スタッフの意識

川原みちよ, 中塚幹也

母性衛生 52 ( 1 ) 2011

A Possible Mechanism of Autoimmune-Mediated infertility in Women with Endometriosis.

37 ( 5 ) 402 - 411 2011

不育症over view

齋藤滋, 杉浦真弓, 丸山哲夫, 田中忠夫, 竹下俊行, 山田秀人, 小澤伸晃, 中塚幹也, 木村正, 藤井知行, 下屋浩一郎, 山本樹生, 佐田文宏, 康東天, 早川智, 一瀬白帝, 柳原格, 秦健一郎, 勝山博信, 堤康央, 中野有美, 福井淳史, 杉俊隆

産婦人科の実際 60 ( 10 ) 2011

ストレス・抑うつと不育症

中塚幹也

産婦人科の実際 60 ( 10 ) 2011

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