MISC - 三村　由香里

In vitro macro- and micro-autoradiographic localization of V1 and V2 receptors in the rat kidney using OPC-21268 and OPC-31260. (共著)

Nephron   76 ( 3 )   331 - 336   1997年

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記述言語：英語  

DOI： 10.1159/000190200

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Alterations of renal V1 and V2 receptors in spontaneously hypertensive rats and DOCA-salt hypertensive rats using computerized quantification for macro-autoradiogram. (共著)

Res Commun Mol Pathol Parmacol   95 ( 1 )   43 - 56   1997年

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記述言語：英語  

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A patient with sarcoidosis associated with recurrent urolithiasis and tubular injury caused by calcium deposition

Yukari Mimura, Yohei Maeshima, Toshio Ogura, Naoki Kashihara, Kenji Kawabata, Nobuhiko Hayakawa, Yoshio Nagake, Kazue Hironaka, Hirofumi Makino, Zensuke Ota, Jingo Kageyama

Japanese Journal of Nephrology   38 ( 3 )   141 - 145   1996年

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記述言語：英語  

A 38-year-old woman was hospitalized in January, 1994 with renal dysfunction and hypercalcemia. Before admission, she was diagnosed as having urolithiasis, and had been treated twice with extracorporeal shock wave lithotripsy (ESWL). Ophthalmologically, she exhibited iritis and secondary glaucoma. Hypercalcemia, an extremely low titer of parathyroid hormone (PTH), and elevation of angiotensin-converting enzyme (ACE) and lysozyme activity were noted. These findings suggested sarcoidosis, although the chest X-ray showed only fibrotic changes. Hypercalcemia was suspected of having been caused secondarily by sarcoidosis. Since her laboratory data also showed renal dysfunction and abnormal unnalysis, a renal biopsy was performed. The histological findings indicated a tubular and interstitial disorder without glomerular abnormality
calcium deposition, which was detected by X-ray energy dispersive analysis, was observed in the tubular cytoplasm. Administration of prednisolone alleviated the renal dysfunction and decreased the elevation of ACE activity and lysozyme level of the blood. Sarcoidosis is sometimes associated with hypercalcemia, but rarely with renal dysfunction. These findings suggested that sarcoidosis may be associated with renal dysfunction due to tubular injury caused by calcium deposition in the tubules, and that glucocorticoid therapy was effective for these disorders.

DOI： 10.14842/jpnjnephrol1959.38.141

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A patient with sarcoidosis associated with recurrent urolithiasis and tubular injury caused by calcium deposition. (共著)

Jpn J Nephrol   38 ( 3 )   141 - 145   1996年

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記述言語：英語  

DOI： 10.14842/jpnjnephrol1959.38.141

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Effect of vasopressin V1- and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats.

Mimura Yukari, Ogura Toshio, Yamauchi Takayoshi, Otsuka Fumio, Oishi Tetsuya, Harada Kazushi, Hashimoto Masami, Ota Zensuke

Acta Medica Okayama   49 ( 4 )   187 - 194   1995年8月

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記述言語：英語   出版者・発行元：Okayama University Medical School  

<p>We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.</p>

DOI： 10.18926/AMO/30375

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Effect of vasopressin V1-and V2-receptor stimulation on blood pressure in DOCA-salt hypertensive rats. (共著)

Mimura Yukari, Ogura Toshio, Yamauchi Takayoshi, Otsuka Fumio, Oishi Tetsuya, Harada Kazushi, Hashimoto Masami, Ota Zensuke

Acta Med Okayama   49 ( 4 )   187 - 194   1995年8月

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記述言語：英語   出版者・発行元：Okayama University Medical School  

<p>We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.</p>

DOI： 10.18926/AMO/30375

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In vitro micro-autoradiography of atrial natriuretic peptide in biopsy specimens from patients with renal diseases. (jointly worked)

Ogura T, Asano N, Katayama E, Oishi T, Mimura Y, Hironaka K, Kashihara N, Makino H, Ota Z, Ogawa N

Journal of Medicine   25   203 - 217   1994年

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