研究者詳細 - 三村　由香里

MISC - 三村　由香里

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小学生における調節誤差に関する検討－近視進行と読書距離に着目して－

宝諸昌世, 三村由香里, 大角博子, 長谷部聡, 高橋香代

学校保健研究 2005年

中枢性尿崩症で発症し，汎下垂体機能低下を来したgerminomaの１例

稲垣兼一, 大塚文男, 松井利浩, 鈴木二郎, 武田昌也, 三好智子, 加納義浩, 岸田雅之, 三村由香里, 小倉俊郎, 市村浩一, 景山甚郷, 槇野博史

日本内分泌学会雑誌 2005年

Aldosterone regulation for 18 years in a case of primary aldosteronism

T Miyoshi, F Otsuka, T Ogura, J Suzuki, K Inagaki, M Takeda, M Kishida, Y Mimura, A Nagai, H Makino

AMERICAN JOURNAL OF HYPERTENSION 17 ( 6 ) 546 - 548 2004年6月

Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002

T Ogura, K Matsuura, Y Matsumoto, Y Mimura, M Kishida, F Otsuka, K Tobe

METABOLISM-CLINICAL AND EXPERIMENTAL 53 ( 4 ) 448 - 453 2004年4月

記述言語：英語出版者・発行元：W B SAUNDERS CO

The aim of the present study was to determine the change of serum uric acid (UA) levels in male adolescents and to characterize the relationship between UA levels and obesity or its related factors. This study was conducted in 17,155 students at enrollment in Okayama University from 1991 through 2002, in which the mean serum UA level as a whole was 5.64 +/- 0.009 mg/dL (mean +/- SEM) and the incidence of hyperuricemia (greater than or equal to7.6 mg/dL) was 4.13%. Serum UA levels were correlated with obesity-related indicators, including body mass index (BMI; r = 0.282, P < .0001) and skin-fold thickness (r = 0.286, P < .0001). The incidence of hyperuricemia was increased in parallel with BMI. In the last 4 years (1999 through 2002) of the study period, serum UA levels (5.76 mg/dL) and the incidence of hyperuricemia (4.5%) were significantly increased compared with those in the earlier period (1991 through 1994: 5.50 mg/dL and 3.5%, respectively). However, BMI has been rather gradually decreased throughout 12-year observation in all the subjects. Hyperuricemia was related to the presence of other risk factors, including hypercholesterolemia, liver function abnormality, and hypertension. The frequencies of such abnormalities were higher than euuricemic subjects and this trend was notable in the most recent students enrolled from 1999 through 2002. Hyperuricemia was even found in the group of non-obese male adolescents. Taking into consideration that hyperuricemia is associated with a high prevalence of lifestyle-related diseases in adults, it is of great importance to prevent hyperuricemia at the early stage in Japanese adolescents. (C) 2004 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.metabol.2003.11.017

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妊娠中に顕在化した周期性クッシング病の一例

大塚文男, 三好智子, 鈴木二郎, 稲垣謙一, 武田昌也, 岸田雅之, 三村由香里, 小倉俊郎, 景山甚郷, 橋本浩三, 槇野博史

ACTH RELATED PEPRIDES 15 187 - 193 2004年

記述言語：日本語出版者・発行元：間脳・下垂体・副腎系研究会

19歳女.妊娠後33週より高血圧・蛋白尿が出現し,35週には浮腫と体重増加を伴う妊娠中毒症を呈した.食事療法と安静によって妊娠36週に経腟分娩で男児を出産した.しかし,出産後も体重増加と高血圧が持続し,産後4ヵ月には尿路結石にも罹患した.血中ACTH高値とコルチゾール高値を認めたためクッシング症候群を疑い,入院となった.精査によりクッシング病と診断し,外来で経過観察を続けた.クッシング徴候が臨床的に増悪したため,経蝶形骨洞的下垂体腫瘍摘出術を施行した.摘出した下垂体腫瘍は免疫組織学的にACTH産生性腺腫であった.現在は長時間作用ドパミンアゴニストであるカベルゴリンによる後療法を行い経過観察中であるが再発は認めていない

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論文で用いられている養護教諭の行う判断・診断に関する「ことば」と「その対象」

岡田加奈子, 斎藤理砂子, 山本雅, 酒井都仁子, 徳山美智子, 葛西敦子, 三村由香里, 高田しずか, 藤澤雅子, 井上智恵子, 岩田美保, 西能代

日本教育保健研究会年報 ( 12 ) 15 - 26 2004年

養護教諭のための養護診断開発に向けての課題－看護診断からの考察－

葛西敦子, 岡田加奈子, 三村由香里, 徳山美智子

弘前大学教育学部紀要 92 167 - 171 2004年

記述言語：日本語出版者・発行元：弘前大学

養護診断に関しての重要性と必要性が指摘されている｡養護診断という言葉を最も多く使用しているのは杉浦氏である｡養護教諭は｢児童･生徒の養護をつかさどる｣専門職である｡養護教諭が教育の専門職として,養護診断を理論的に体系化することが求められる｡そこで,養護と近接領域にある看護の看護診断について概観し検討することで,養護診断に関する問題点と課題を明らかにした｡養護診断を開発するには,まず,養護教諭の職能団体や学会が一体となり,｢養護とは何か｣という養護の定義を明確にすることが重要である｡次に,杉浦氏は養護診断における診断をAssessmentとしているが,適切な用語を選択するための議論をし,養護過程をも含め,養護診断を再構築していく必要がある｡看護師が看護診断に看護専門職としての独自の機能を反映させたように,養護診断を確立することで,養護教諭の独自性や専門職性を兄いだすことができるものと期待する。

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その他リンク： http://hdl.handle.net/10129/613

養護教諭の行う養護診断の確立に向けて医学領域における「診断」から考える

三村由香里, 岡田加奈子, 葛西敦子, 徳山美智子

日本保健医療行動科学学会年報 19 217 - 223 2004年

蝶形骨洞内に発生した異所性ACTH産生下垂体腺腫の１例

鈴木二郎, 大塚文男, 武田昌也, 三好智子, 稲垣謙一, 岸田雅之, 三村由香里, 小倉俊郎, 橋本浩三, 槇野博史

ホルモンと臨床 52 6 - 10 2004年

A lethal complication, acute necrotizing pancreatitis, of Turnerﾕs syndrome with primary hyperparathyroidism

Kishida M, Otsuka F, Mimura Y, Ogura T, Makino H

Endocrine J 50 ( 6 ) 835 - 836 2003年12月

Hypothyroidism associated with anti-human chorionic gonadotropin antibodies secondarily produced by gonadotropin in a case of idiopathic hypothalamic hypogonadism

T Ogura, Y Mimura, F Otsuka, M Kishida, K Yokota, J Suzuki, A Nagai, S Hirakawa, H Makino, K Tobe

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 26 ( 11 ) 1128 - 1135 2003年11月

記述言語：英語出版者・発行元：EDITRICE KURTIS S R L

We report a 22-yr-old male patient with idiopathic hypothalamic hypogonadism who showed secondary resistance to gonadotropin (Gn) therapy over 3 yr after successful treatment with hCG combined with human menopausal Gn. The patient simultaneously developed subclinical hypothyroidism. Endocrine examination revealed low levels of testosterone (0.3 ng/ml), free T-4 (0.91 ng/dl), and increased levels of TSH (31.1 muU/ml) in the serum. Serum autoantibodies to thyroid gland were all negative. Interestingly, thyroid function was improved after discontinuation of Gn therapy. In vitro assays by immunoprecipitation using (125)l-hCG or (125)l-TSH elucidated the presence of anti-hCG antibody in the serum 13 months after commencement of Gn therapy but anti-TSH antibody was not detected in the serum. Furthermore, the anti-hCG antibody specifically bound to hCG but not to other glycoproteins including TSH and FSH based on a competitive displacement assay. Bioassays using porcine thyroid cells revealed that the serum gamma-globulin fraction enables the suppression of cyclic AMP (cAMP) synthesis stimulated by TSH. Our findings suggest that anti-hCG and/or anti-idiotypic hCG antibodies induced by hCG therapy impaired TSH-dependent cAMP production through interfering with binding of TSH to its receptor, and this resulted in subclinical hypothyroidism in this patient. (C) 2003, Editrice Kurtis.

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Role of bradykinin in renoprotective effects by angiotensin II type 1 receptor antagonist in salt-sensitive hypertension

K Yokota, M Kishida, T Ogura, J Suzuki, F Otsuka, Y Mimura, M Takeda, Y Nakamura, H Makino

HYPERTENSION RESEARCH 26 ( 3 ) 265 - 272 2003年3月

記述言語：英語出版者・発行元：JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE

To elucidate whether bradykinin is involved in the renoprotective effect produced by angiotensin II type 1 receptor antagonist (AT1A) in chronic salt-sensitive hypertension, Dahl salt-sensitive rats receiving a high-salt (8%) diet were treated either with an AT1A (candesartan, 1 mg/kg/day), a bradykinin B2 receptor antagonist (BKB2A; FR172357, 30 mg/kg/day) or a combination of AT1A and BKB2A for 7 weeks. None of the treatments changed the markedly increased systolic blood pressure induced by a high-salt diet. However, chronic treatment with AT1A significantly improved the histological hallmarks of renal damage-i.e., glomerular sclerosis and cell proliferation-despite the presence of severe hypertension. This beneficial action of AT1A was abolished by the concomitant administration of BKB2A. In agreement with these histologically based findings, increases in levels of creatinine clearance induced by AT1A were also reversed back to the basal levels when BKB2A was administered in conjunction with AT1A. Furthermore, urinary excretions of nitrate plus nitrite and prostaglandin E-2 increased moderately in response to the administration of AT1A alone, but not in combination with BKB2A. Thus, the blockade of bradykinin signaling abrogates the renoprotective actions of the angiotensin II type 1 (AT1) receptor antagonism. Collectively, these data show that when AT1 action is chronically blocked, endogenous bradykinin plays a pivotal role in preventing the progression of glomerular injury in salt-sensitive hypertension.

DOI： 10.1291/hypres.26.265

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Relationship between adrenomedullin and vasopressin-aquaporin system under general anesthesia

T Ogura, K Morita, M Takeuchi, F Otsuka, T Iwasaki, K Oe, K Matsuura, K Tobe, Y Mimura, M Kishida, H Makino, M Hirakawa

HORMONE RESEARCH 59 ( 1 ) 30 - 34 2003年

記述言語：英語出版者・発行元：KARGER

Aim:The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia. Copyright (C) 2003 S. Karger AG, Basel.

DOI： 10.1159/000067933

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岡山大学における養護教諭養成カリキュラムの開発

高橋香代, 伊藤武彦, 三村由香里, 河内信子, 小出彌生, 門田新一郎

教科教育学研究 21 145 - 158 2003年

学校保健の現場における看護的支援を要する児童・生徒の実態とこれからの支援のあり方

岡田加奈子, 三村由香里

リハビリテーション看護研究 2003年

Issue and challenge in Yogo diagnosis.

Atsuko K, Okada K, Mimura Y, Tokuyama M

Japanease Journal of School Health 2003年

教育学部養護教諭養成の看護系科目に対する卒業生の学習ニーズ

福田博美, 天野敦子, 岡田加奈子, 本田優子, 松嶋紀子, 芝木美沙子, 津村直子, 小出やよい, 三村由香里, 中村朋子, 西沢義子

学校保健研究 45 ( 4 ) 331 - 342 2003年

教育学部養護教諭養成の臨床実習に対する卒業生の学習ニーズ

本田優子, 岡田加奈子, 天野敦子, 福田博美, 松嶋紀子, 芝木美沙子, 津村直子, 小出やよい, 三村由香里, 中村朋子, 西沢義子

学校保健研究 45 ( 4 ) 331 - 342 2003年

Relationship between reduced serum IGF-I levels and accumulation of visceral fat in Japanese men

M Kunitomi, J Wada, K Takahashi, Y Tsuchiyama, Y Mimura, K Hida, N Miyatake, M Fujii, S Kira, K Shikata, H Makino

INTERNATIONAL JOURNAL OF OBESITY 26 ( 3 ) 361 - 369 2002年3月

記述言語：英語出版者・発行元：NATURE PUBLISHING GROUP

OBJECTIVE: To investigate whether the changes in IGF-1 concentrations after weight reduction in Japanese overweight men are associated with changes in visceral and subcutaneous fat.
DESIGN: Cross-sectional and longitudinal clinical intervention study with exercise education.
SUBJECTS: One-hundred and twelve Japanese overweight men aged 30-59y (body mass index (BMI) 28.4+/-2.5 kg/m(2)) and 33 normal-weight men aged 30-39y (BMI 22.1+/-1.5 kg/m(2)) at baseline. From the participants, 56 randomly selected overweight men (BMI 28.8+/-2.8) were further enrolled into a 1 y exercise program.
MEASUREMENTS: Fat distribution was evaluated by visceral fat M and subcutaneous fat (S) areas measured with computed tomography scanning at umbilical levels, metabolic parameters and hormones including insulin, leptin and IGF-1 at baseline and after 1 y.
RESULTS: In 112 overweight subjects at baseline, insulin (10.5+/-5.0 muUl/ml) and leptin (6.4+/-3.7 ng/ml) significantly correlated with both V (r=0.260, P=0.0073; r=0.410, P<0.0001) and S areas (r=0.377, P<0.0001; r=0.613, P<0.0001), respectively. IGF-1 (156.8+/-48.7 muU/ml) significantly and negatively correlated with V area (r= -0.242, P=0.0125)and age (r= - 0.192, P=0.0480). In normal-weight men aged 30-39y (n=33) and age-matched subjects (n=30) selected from the 112 overweight men, the serum IGF-1 further tightly correlated with V area (r= - 0.467, P<0.0001). Visceral fat area and age were independently related to serum IGF-1 levels by multiple regression analysis. By intervention with exercise education, 56 overweight subjects showed an increase in daily steps (6224+/-2781 to 7898+/-4141 steps/day) and reduction of BMI (28.8+/-2.8 to 27.7+/-2.9). DeltaIGF-1 significantly correlated with DeltaV area (r= - 0.432, P = 0.0009) but not with DeltaS area or DeltaBMI.
CONCLUSION: The present study indicated a negative correlation between IGF-1 levels and visceral fat at baseline as well as an association between the reduction in visceral fat and increase in IGF-1 levels after an exercise intervention.

DOI： 10.1038/sj/ijo/0801899

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Basedow病で発症し中枢性甲状腺機能低下に移行した1型糖尿病の一例

永瀬亮, 臼井仁美, 松田充浩, 大石徹也, 四方賢一, 槇野博史, 小倉俊郎, 三村由香里, 和田淳

糖尿病 45 ( 2 ) 162 - 162 2002年2月

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