研究者詳細 - 三村　由香里

Junko Goto, Fumio Otsuka, Ryo Kodera, Tomoko Miyoshi, Masaru Kinomura, Hiroyuki Otani, Yukari Mimura, Toshio Ogura, Hiroyuki Yanai, Yasutomo Nasu, Hirofumi Makino

ENDOCRINE JOURNAL 55 ( 1 ) 175 - 181 2008年2月

記述言語：英語出版者・発行元：JAPAN ENDOCRINE SOC

A 73-year-old Japanese woman was referred for examination of right flank pain and progressive hypertension. Abdominal CT incidentally detected a right adrenal mass 8 cm in size. The tumor exhibited isodensity by CT and contained high-intense lesion by T2-weighted MRI. Scintigraphy with I-131-metaiodobenzylguanidine and I-131-adosterol showed no abnormal uptake by whole body scan. Positron emission tomography scan with F-18-2-fluoro-D-deoxyglucose demonstrated an exclusive uptake in the right adrenal mass. Adrenocortical hormone levels and catecholamine secretion were within normal range; however, the level of serum neuron-specific enolase (NSE) was found to be markedly high. After controlling systemic blood pressure with an alpha 1-blocker, the right adrenal tumor was surgically removed, along with the right kidney and inferior vena cava which adhered to it. The tumor was pathologically proven to be leiomyosarcoma, which was immunohistochemically positive with a-smooth muscle actin and negative with CD57, S-100 and c-kit proteins. Notably, NSE protein was massively expressed in the resected tumor. After surgery blood pressure was controlled with regular medication and serum NSE levels have since normalized. The possibility of leiomyosarcoma should be kept in mind in adrenal incidentalomas with rapid growth and atypical radiological images. Our findings suggest that circulating NSE levels may be clinically useful for early detection of recurrence.

DOI： 10.1507/endocrj.K07E-020

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甲状腺機能低下症により顕在化したApparent Mineralocorticoid Excwss(AME)病態の一例

稲垣兼一, 大塚文男, 鈴木二郎, 三好智子, 大谷寛之, 三村由香里, 小倉俊郎, 槇野博史

ホルモンと臨床 56 119 - 123 2008年

学校救急処置における養護教諭の役割－判例にみる職務の分布から－

河本妙子, 松枝睦美, 上村弘子, 三村由香里, 高橋香代

学校保健研究 50 ( 4 ) 221 - 233 2008年

養護実践のための頭部外傷チェックリストの提案

三村由香里, 松枝睦美, 藤尾由美, 中吉千施子, 上村弘子, 藤原さとこ, 田代桂子, 武田和子, 河本妙子, 高橋香代

日本養護教諭教育学会誌 11 ( 1 ) 16 - 25 2008年

養護教諭の救急処置における困難と今後の課題－記録と研修に着目して－

武田和子, 三村由香里, 松枝睦美, 河本妙子, 上村弘子, 高橋香代

日本養護教諭教育学会誌 11 ( 1 ) 33 - 43 2008年

Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope LβT2 cells.

Takeda M, Otsuka F, Otani H, Inagaki K, Miyoshi T, Suzuki J, Mimura Y, Ogura T, Makino H

J of Endocrionlogy 194 ( 1 ) 87 - 99 2007年7月

リンパ球性漏斗神経葉炎と肺癌脳転移を伴った中枢性尿崩症の一例

大谷寛之, 大塚文男, 廣田大昌, 三好智子, 稲垣兼一, 鈴木二郎, 後藤順子, 三村由香里, 小倉俊郎, 田端雅弘, 槇野博史

日本内分泌学会雑誌 83suppl 208 - 210 2007年

養護診断『心理的な要因が存在する可能性のある状態』の診断名と診断指標の開発

岡田加奈子, 葛西敦子, 三村由香里, 徳山美智子, 竹鼻ゆかり, 荒木田美香子, 荒川雅子, 井上智恵子, 齋藤理砂子, 西能代, 冨塚都仁子, 高田しずか, 外間朝子, 岩田美保, 山本雅

日本養護教諭教育学会誌 10 1 - 18 2007年

MDSを合併した先端巨大症に対するオクトレオチドによる１治療例

三好智子, 大塚文男, 稲垣兼一, 鈴木二郎, 大谷寛之, 後藤順子, 三村由香里, 小倉俊郎, 景山甚郷, 前田嘉信, 槇野博史

日本内分泌学会雑誌 83suppl 79 - 81 2007年

高血圧の精査にて発見されたNSE産生性副腎平滑筋肉腫の一例.

後藤順子, 大塚文男, 小寺亮, 稲垣兼一, 三好智子, 大谷寛之, 鈴木二郎, 三村由香里, 小倉俊郎, 那須保友, 柳井広之, 槇野博史

日本内分泌学会雑誌 83 242 - 245 2007年

多嚢胞性卵巣症候群を合併した先端巨大症の一例.

大塚文男, 稲垣兼一, 鈴木二郎, 三好智子, 大谷寛之, 後藤順子, 三村由香里, 小倉俊郎, 槇野博史

第三回アクロメガリーフォーラム記録集 10 2007年

Mutual regulation of follicle-stimulating hormone signaling and bone morphogenetic protein system in human granulosa cells

T Miyoshi, F Otsuka, Suzuki, I, M Takeda, K Inagaki, Y Kano, H Otani, Y Mimura, T Ogura, H Makino

BIOLOGY OF REPRODUCTION 74 ( 6 ) 1073 - 1082 2006年6月

記述言語：英語出版者・発行元：SOC STUDY REPRODUCTION

Bone morphogenetic proteins (BMPs) play critical roles in folliculogenesis by modulating the actions of follicle-stimulating hormone (FSH) in the ovary. However, the effects of FSH on the BMP system remain unknown. Here, we have investigated the effects of FSH on BMP signaling using the human granulosa-like tumor cell line KGN. KGN cells express BMP type 1 and type II receptors and the BMP signaling molecules SMADs. FSH administration upregulated BMP type IA (BMPR1A) and IB (BMPR1B) receptors, activin type II receptor (ACVR2), and BMP type II receptor (BMPR2). FSH also augmented SMAD1 and SMAD5 expression, and conversely, FSH suppressed the expression of the inhibitory SMADs, SMAD6 and SMAD7. Bioassays revealed that FSH enhances BMP-induced SMAD1/5/8 phosphorylation and cellular DNA synthesis induced by BMP6 and BMP7. Since overexpression of BMPR1A and BMPR1B, but not SMADs, significantly enhanced the BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells. BMPs significantly suppressed progesterone synthesis induced by forskolin and dibutyryl-cAMP (BtcAMP) but had no effect on estradiol induced by the same factors. KGN cAMP levels induced by forskolin were not altered by BMPs, suggesting that BMPs regulate steroidogenesis at a level downstream of cAMP synthesis in KGN cells. In this regard, BMPs specifically reduced the STAR transcription, whereas the levels of CYP11A, HSD3B2, and CYP19 stimulated by forskolin as well as BtcAMP were not altered. Collectively, the two major factors, FSH-cAMP pathway and BMP system, are reciprocally and functionally linked. Given that BMPs downregulate FSH receptors in KGN cells, this interaction may contribute to finetuning of the mutual sensitivity toward BMP ligands and FSH.

DOI： 10.1095/biolreprod.105.047969

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Involvement of bone morphogenetic protein-6 in differential regulation of aldosterone production by angiotensin II and potassium in human adrenocortical cells

Kenichi Inagaki, Fumio Otsuka, Jiro Suzuki, Yoshihiro Kano, Masaya Takeda, Tomoko Miyoshi, Hiroyuki Otani, Yukari Mimura, Toshio Ogura, Hirofumi Makino

ENDOCRINOLOGY 147 ( 6 ) 2681 - 2689 2006年6月

記述言語：英語出版者・発行元：ENDOCRINE SOC

Aldosterone production is modified by several growth factors that reside in the adrenal. We have recently reported the existence of a bone morphogenetic protein (BMP) system in human adrenocortical cells, in which BMP-6 augments aldosterone synthesis. Here, we investigated functional roles of BMP-\6, focusing on the differential regulation of aldosterone synthesis induced by angiotensin (Ang) II and potassium (K). In human adrenocortical H295R cells, BMP-6 augmented Ang II-induced CYP11B2 transcription and mRNA and aldosterone roduction but had no effect on K-induced aldosterone production. Inhibition of endogenous BMP-6 action by neutralizing antibodies impaired aldosterone production induced by Ang II but not that induced by K. Blockage of ligand-receptor binding using extracellular domain (ECD) of BMP type I receptors revealed that ECDs to activin receptor-like kinase (ALK)-2 and ALK-3 significantly reduced the aldosterone production induced by Ang II. None of the type I-receptor ECDs tested had any effect on K-induced aldosterone levels. Overexpression of a dominant negative-activin type II receptor construct selectively decreased Ang II-induced aldosterone production without having any effect on K-induced aldosterone production. BMP type II receptor-dominant negative had no effect on aldosterone induced by either Ang II or K. These results infer that BMP-6 acts through ALK-2, ALK-3, and activin type II receptor receptors in adrenocortical cells. BMP-6 pretreatment extends the induction of ERK1/2 phosphorylation by Ang II and treatment with ECDs to ALK-2 and ALK-3 impaired Ang II-induced ERK phosphorylation. The specific inhibitor of ERK activation, U0126, suppressed the activation of CYP11B2 transcription induced by BMP-6 without affecting Smad phosphorylation and Tlx2-Luc activity. Collectively, the endogenous BMP-6 system plays critical roles in aldosterone production between Ang II and K through ERK signaling pathway.

DOI： 10.1210/en.2005-1250

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バセドウ病を合併した甲状腺不応症の１例

稲垣兼一, 大塚文男, 鈴木二郎, 三好智子, 武田昌也, 大谷寛之, 中村絵里, 三村由香里, 小倉俊郎, 槇野博史

日本内分泌学会雑誌 2006年

Functional roles of the bone morphogenetic protein system in thyrotropin signaling in porcine thyroid cells

J Suziki, F Otsuka, M Takeda, K Inagaki, T Miyoshi, Y Mimura, T Ogura, H Doihara, H Makino

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 327 ( 4 ) 1124 - 1130 2005年2月

記述言語：英語出版者・発行元：ACADEMIC PRESS INC ELSEVIER SCIENCE

We uncovered a new regulation of thyrocyte function by bone morphogenetic protein (BMP) under the influence of thyrotropin (TSH) using primary culture of porcine thyrocytes. The BMP type I receptors, ALK-2 (ActRIA), -3 (BMPRIA), and -6 (BMPRIB), were expressed in porcine thyrocytes, while ALK-6 was not detected in human thyroid. Treatment with BMP-2,-4,-6,-7, and TGF-beta1 exhibited a dose-dependent suppression of DNA synthesis by porcine thyrocytes. BMP-2, -4, -6, -7, and TGF-beta1 suppressed TSH receptor mRNA expression on thyrocytes, which was consistent with their suppressive effect on TSH-induced cAMP synthesis and TSH-induced insulin-like growth factor-1 expression. Activin exhibited minimal suppression of thyrocyte DNA synthesis and did not exhibit suppressive effects on TSH receptor mRNA expression. Phosphorylated Smad1/5/8 was detected in the lysates of porcine thyrocytes treated with BMP-2, -4,-6, and -7. However, in the presence of TSH, BMP-6 and -7 failed to activate Smad1/5/8 phosphorylation and 3TP-reporter activity, whereas BMP-2 and -4 maintained clear activation of the BMP signaling regardless of the presence of TSH. This diverged regulation of thyroid BMP system by TSH is most likely due to the reduction of ALK-6 expression caused by TSH. Thus, the thyroid BMP system is functionally linked to TSH actions through modulating TSH receptor expression and TSH, in turn, selectively inhibits BMP signaling. Given that BMP system is present in human thyroid and the expression pattern of ALK-2 and BMPRII is different between follicular adenomas and normal thyroid tissues, the endogenous BMP system may be involved in regulating thyrocyte growth and TSH sensitivity of human thyroid adenomas. (C) 2004 Elsevier Inc. All rights reserved.

DOI： 10.1016/j.bbrc.2004.12.122

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副腎偶発腫の経過観察中に両側副腎の腫大を生じ，PETにより原発巣を検出した転移性副腎腫瘍の一例

大塚文男, 三好智子, 鈴木二郎, 稲垣謙一, 武田昌也, 加納義浩, 岸田雅之, 三村由香里, 小倉俊郎, 景山甚郷, 橋本浩三, 槇野博史

ACTH RELATED PEPRIDES 16 223 - 227 2005年

記述言語：日本語出版者・発行元：間脳・下垂体・副腎系研究会

56歳男.健診にて血糖異常を指摘されスクリーニングCTにて右副腎腫瘍を認め,精査目的で入院した.アドステロールシンチを含む検査結果より,非機能性副腎腺腫が疑われたため外来経過観察とした.6ヵ月後右腹部から右腰背部に鈍痛が出現し,腹部画像検査にて副腎腫瘍の増大を認め,腫瘍内出血を疑い入院した.副腎腫瘍はホルモン産生を欠き,両側性であること,非常に急速に増大していることから,副腎癌,転移,悪性リンパ腫などが考えられたが,ガリウムシンチ・骨シンチでリンパ節転移は否定された.開腹手術により両側性副腎摘出術を施行し,副腎組織に腺癌浸潤像を認めた.術後,FDG-PET検査にて左上肺野に有意な核種取り込みを認め,肺腺癌の両側副腎転移として化学療法を行ったが,肺のブラ所見に変化は認められなかった

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