研究者詳細 - 中村　宜督

MISC - 中村　宜督

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アピゲニンの細胞内プロオキシダント作用

中村宜督, 難波きさ, 三好規之, 山田貴代, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2004 77 2004年3月

ベンジルイソチオシアナートの抗炎症作用

中村宜督, 高林聡子, 三好規之, 大沢俊彦

日本農芸化学会関西支部講演会講演要旨集 2003 20 2003年10月

Benzyl isothiocyanateによる細胞周期特異的な細胞死に関する解析

三好規之, 中村宜督, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2003 62 2003年3月

ショウガ科植物に含まれるアポトーシス誘導物質

中村宜督, 上田泰弘, 三好規之, 阿部雅子, 小沢好夫, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2003 62 2003年3月

Wasabi: A Traditional Japanese Food That Contains an Exceedingly Potent Glutathione S-Transferase Inducer for RL34 Cells

Yasujiro Morimitsu, Yasujiro Morimitsu, Y. Nakamura, Y. Nakamura, T. Osawa, K. Uchida

ACS Symposium Series 807 301 - 309 2002年12月

In the course of our screening of edible plants on the induction of glutathione S-transferase (GST) activity in rat liver epithelial RL34 cells, 6-methylsulfinylhexyl isothiocyanate (MS-1TC) was isolated from wasabi (Wasabia japonica) as a potential inducer of GST. As a result from western blot analyses of GST expression induced by MS-ITC in RL34 cells, increasing of protein levels of both GST-Ya and GST-Yp were detected. And as a result from time dependent GSH level by MS-ITC, the GSH level in RL34 cells was initially decreased, then increased gradually to 1.8 times higher than its basal level after 12 hrs. By adding benzyl isothiocyanate (BITC) isolated from papaya instead of MSITC to the cells, the reactive oxygen intermediates (ROIs) detected by a fluorescence probe were increased immediately. From these data, we discuss the relation between levels of intracellular oxidation and the induction of GST.

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Benzyl isothiocyanateによる細胞周期停止機構の解析

三好規之, 中村宜督, 内田浩二, 大沢俊彦

生化学 74 ( 8 ) 902 - 902 2002年8月

アピゲニンのアポトーシス誘導における活性酸素の役割

難波きさ, 三好規之, 山田貴代, 大沢俊彦, 内田浩二, 中村宜督

生化学 74 ( 8 ) 1064 - 1064 2002年8月

植物性食品因子アピゲニンによる細胞死誘導機構の解析

中村宜督, 三好規之, 内田浩二, 大沢俊彦

日本癌学会総会記事 61st 478 2002年8月

フラボノイドによる細胞死誘導と活性酸素の関与

中村宜督, 山田貴代, 三好規之, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2002 245 2002年3月

食品因子benzyl isothiocyanateによるredox感受性細胞死の誘導機構

三好規之, 中村宜督, 内田浩二, 大沢俊彦

日本農芸化学会大会講演要旨集 2002 245 2002年3月

Role of p38 mitogen-activated protein kinase in the 4-hydroxy-2-nonenal-induced cyclooxygenase-2 expression

T Kumagai, Y Nakamura, T Osawa, K Uchida

FREE RADICAL BIOLOGY AND MEDICINE 33 S67 - S68 2002年

Search for chemopreventive agents on the basis of the involvement of oxidative stress and inflammation in carcinogenesis 査読

A Murakami, Y Nakamura, K Koshimizu, H Ohigashi

ANIMAL CELL TECHNOLOGY : BASIC & APPLIED ASPECTS, VOL 12 57 - 61 2002年

記述言語：英語出版者・発行元：SPRINGER

Cancer chemoprevention with food phytochemicals is currently regarded as one of the noticeable scientific fields. We have screened more than 400 extracts from vegetables and fruits for the anti-tumor promoting activity using a cell culture system. The Zingiberaceae plants in Southeast Asian countries were indicated to be notable sources to identify effective cancer chemopreventive agents. In addition, F-acetoxychavicol acetate (ACA), a phenyl propanoid, isolated from the rhizomes of Languas galanga, was found to be a potent chemopreventive agent which markedly suppresses phorbol ester-induced superoxide (O-2(.)) generation and endotoxin-induced nitric oxide (NO) production.

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Food phytochemicals suppressing free-radical generation: Implications for cancer chemoprevention.

A Murakami, Y Nakamura, K Koshimizu, H Ohigashi

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 219 U27 - U27 2000年3月

活性酸素による制がんの可能性

中村宜督

バイオサイエンスとインダストリー = Bioscience & industry 57 ( 8 ) 40 - 41 1999年8月

抗腫瘍性プロスタグランジン類による遺伝子発現誘導

川本善之, 内藤裕子, 鳥居恭好, 中村宜督, 大東肇, 今川正良, 佐藤公彦, 大澤俊彦, 内田浩二

生化学 71 ( 8 ) 882 - 882 1999年8月

Auraptene, an Alkyloxylated Coumarin from Citrus natsudaidai HAYATA, Inhibits Mouse Skin Tumor Promotion and Rat Colonie Aberrant Crypt Foci Formation

Akira Murakami, Wataru Kuki, Yasuo Takahashi, Hiroshi Yonei, Takuji Tanaka, Hiroki Makita, Keiji Wada, Naomi Ueda, Masanobu Haga, Yoshimasa Nakamura, Yoshimi Ohto, Oe Kyung Kim, Hajime Ohigashi, Koichi Koshimizu, Koichi Koshimizu

ACS Symposium Series 701 86 - 95 1998年12月

Auraptene, a coumarin-related compound, has been isolated from the cold-pressed oil of natsumikan (Citrus natsudaidai HAYATA), as an inhibitor of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein-Barr virus (EBV) activation in Raji cells. In a two-stage carcinogenesis experiment with 1.6 nmol of TPA and 0.19 μmol of 7,12-dimethyl benz[a]anthracene (DMBA) in ICR mouse skin, topical application of 160 nmol of auraptene significantly reduced tumor incidence and the number of tumors per mouse by 27% and 23%, respectively. Auraptene at 50 μM almost completely suppressed TPA-induced superoxide (O 2 - )and hydroperoxide (ROOH) generation in differentiated HL-60 cells as well as lypopolysaccharide (LPS)/interferon-γ(IFN-γ)-induced nitric oxide (NO) generation in RAW 264.7 cells. Dietary feeding of auraptene at a dose of 100 or 500 ppm inhibited azoxymethane (AOM)-induced rat colonic aberrant crypt foci (ACF) formation in a dose-dependent manner. Oral administration of auraptene (50 - 200 mg/kg body wt.) clearly enhanced the glutathione S-transferase (GST) activity in mouse liver, suggesting that auraptene is an effective chemopreventer in both tumor initiation and promotion phases.

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フェノール性抗酸化剤の発がん抑制に対する二面性

中村宜督

化学と生物 36 ( 11 ) 728 - 729 1998年11月

熱帯アジアの食材の発癌抑制効果と活性成分 (特集/スパイス・ハ-ブ健康学)

大東肇, 中村宜督, 村上明

Food style 21 2 ( 7 ) 31 - 35 1998年7月

Cellular response to phenolic antioxidants

K Uchida, Y Naito, Y Torii, Y Nakamura, T Kondo, T Osawa

FREE RADICAL BIOLOGY AND MEDICINE 25 S53 - S53 1998年

Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin.

A Murakami, W Kuki, Y Takahashi, H Yonei, Y Nakamura, Y Ohto, H Ohigashi, K Koshimizu

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 213 154 - AGFD 1997年4月

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