Faculty Profiles - TAKAKI Akinobu

MISC - TAKAKI Akinobu

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肝臓治療安全かつ確実なRFA治療を目指した超音波技術の工夫 RFAにおける部分的free-hand法の利点と、ファントムを用いた穿刺トレーニング

中村進一郎, 竹内康人, 能祖一裕, 大西秀樹, 森井和彦, 和田望, 安中幸, 白羽英則, 高木章乃夫, 岡田裕之

超音波医学 45 ( Suppl. ) S329 - S329 2018.4

若年成人の非アルコール性脂肪性肝疾患の経過における遺伝子多型の解析

岩崎良章, 中山光, 池田房雄, 和田望, 安中哲也, 高木章乃夫, 岡田裕之

肝臓 59 ( Suppl.1 ) A353 - A353 2018.4

Acute presentation of autoimmune hepatitis: a multicentre study with detailed histological evaluation in a large cohort of patients

Hiep Nguyen Canh, Kenichi Harada, Hirofumi Ouchi, Yasunori Sato, Koichi Tsuneyama, Masayoshi Kage, Masayuki Nakano, Kaname Yoshizawa, Atsushi Takahashi, Masanori Abe, Jong-Hon Kang, Kazuhiko Koike, Ayano Inui, Tomoo Fujisawa, Akinobu Takaki, Teruko Arinaga-Hino, Takuji Torimura, Yoshiyuki Suzuki, Keiichi Fujiwara, Mikio Zeniya, Hiromasa Ohira, Atsushi Tanaka, Hajime Takikawa

JOURNAL OF CLINICAL PATHOLOGY 70 ( 11 ) 961 - 969 2017.11

Language：English Publisher：BMJ PUBLISHING GROUP

Aims Although liver biopsy is crucial to diagnose and guide treatment decisions, a detailed histological analysis of autoimmune hepatitis (AIH) with clinically acute presentations has not yet been performed. This study aimed to characterise the histological features and explore potential histological hallmarks to diagnose the acute presentation of AIH.
Methods We systematically evaluated liver specimens of 87 adult patients with acute presentation of AIH retrospectively enrolled from Japanese multicentre facilities. Each histological feature was predefined by consensus based on the diagnostic criteria.
Results Key findings were that acute presentation of AIH revealed histological features of both acute hepatitis and chronic hepatitis accompanying various degrees of fibrosis. The prominent features were lobular necrosis/ inflammation (97.7%), plasma cell infiltration (96.4%), emperipolesis (89.3%), pigmented macrophages (84.5%), cobblestone appearance of hepatocytes (82.6%) and perivenular necroinflammatory activity, including centrilobular necrosis (81.4%).
Conclusions The acute presentation of AIH represents the entire histological spectrum of acute hepatitis and chronic hepatitis with various activity grades and fibrosis stages that clinically correspond to acute-onset AIH and acute exacerbation of classic AIH, respectively. Although there are no pathognomonic features for the pathological diagnosis, the prominent presence of lobular and perivenular necroinflammatory activity, pigmented macrophages and cobblestone appearance of hepatocytes in addition to the classic AIH features, such as plasma cell infiltration and emperipolesis, are useful for the pathological diagnosis of the acute presentation of AIH.

DOI： 10.1136/jclinpath-2016-204271

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再発肝癌に対する治療戦略 Salvage transplantationの見極め

楳田祐三, 八木孝仁, 吉田龍一, 信岡大輔, 杭瀬崇, 国府島健, 熊野健二郎, 高木弘誠, 吉田真里, 高木章乃夫, 藤原俊義

移植 52 ( 4-5 ) 414 - 415 2017.11

移植後C型肝炎に対するインターフェロンフリーDAA治療の高い効果

大山淳史, 高木章乃夫, 安中哲也, 足立卓哉, 和田望, 池田房雄, 楳田祐三, 吉田龍一, 信岡大輔, 杭瀬崇, 高木弘誠, 八木孝仁, 岡田裕之

移植 52 ( 4-5 ) 416 - 416 2017.11

肝生検で診断し得た非典型画像の悪性リンパ腫の1例

坂口智紘, 和田望, 大山淳史, 竹内康人, 安中哲也, 大西秀樹, 池田房雄, 中村進一郎, 白羽英則, 高木章乃夫, 岡田裕之

肝臓 58 ( Suppl.3 ) A827 - A827 2017.11

酸化ストレスマーカーを指標とした肝硬変体液貯留患者のトルバプタン治療

足立卓哉, 高木章乃夫, 佐藤秀一, 大山淳史, 和田望, 安中幸, 竹内康人, 安中哲也, 大西秀樹, 池田房雄, 中村進一郎, 白羽英則, 岡田裕之

肝臓 58 ( Suppl.3 ) A860 - A860 2017.11

HCV関連肝細胞癌の根治後にInterferon-free治療を行った312症例の再発と予後の解析

中村進一郎, 能祖一裕, 岡田裕之, 大西秀樹, 白羽英則, 池田房雄, 桑木健志, 安中哲也, 安中幸, 竹内康人, 和田望, 大山淳史, 高木章乃夫, 藤岡真一, 荒木康之, 岩堂昭太, 守本洋一, 安東正晴, 守屋昭男, 萩原宏明, 金吉俊彦, 狩山和也, 谷口英明, 小橋春彦, 熊田卓, 豊田秀徳, 本村健太

肝臓 58 ( Suppl.3 ) A812 - A812 2017.11

腹腔鏡下肝生検による原発性胆汁性胆管炎の予後予測

安中哲也, 池田房雄, 足立卓哉, 和田望, 安中幸, 高木章乃夫, 岩崎良章, 岡田裕之

肝臓 58 ( Suppl.3 ) A907 - A907 2017.11

Living Donor Liver Transplantation for Acute Liver Failure: Comparing Guidelines on the Prediction of Liver Transplantation

Kazuhiro Yoshida, Yuzo Umeda, Akinobu Takaki, Takeshi Nagasaka, Ryuichi Yoshida, Daisuke Nobuoka, Takashi Kuise, Kosei Takagi, Tetsuya Yasunaka, Hiroyuki Okada, Takahito Yagi, Toshiyoshi Fujiwara

ACTA MEDICA OKAYAMA 71 ( 5 ) 381 - 390 2017.10

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

Determining the indications for and timing of liver transplantation (LT) for acute liver failure (ALF) is essential. The King's College Hospital (KCH) guidelines and Japanese guidelines are used to predict the need for LT and the outcomes in ALF. These guidelines' accuracy when applied to ALF in different regional and etiological backgrounds may differ. Here we compared the accuracy of new (2010) Japanese guidelines that use a simple scoring system with the 1996 Japanese guidelines and the KCH criteria for living donor liver transplantation (LDLT). We retrospectively analyzed 24 adult ALF patients (18 acute type, 6 sub-acute type) who underwent LDLT in 1998-2009 at our institution. We assessed the accuracies of the 3 guidelines' criteria for ALF. The overall 1-year survival rate was 87.5%. The new and previous Japanese guidelines were superior to the KCH criteria for accurately predicting LT for acute-type ALF (72% vs. 17%). The new Japanese guidelines could identify 13 acute-type ALF patients for LT, based on the timing of encephalopathy onset. Using the previous Japanese guidelines, although the same 13 acute-type ALF patients (72%) had indications for LT, only 4 patients were indicated at the 1st step, and it took an additional 5 days to decide the indication at the 2nd step in the other 9 cases. Our findings showed that the new Japanese guidelines can predict the indications for LT and provide a reliable alternative to the previous Japanese and KCH guidelines.

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Promising therapeutic efficacy of a novel reduced expression in immortalized cells/dickkopf-3 expressing adenoviral vector for hepatocellular carcinoma

Hiroaki Sawahara, Hidenori Shiraha, Daisuke Uchida, Hironari Kato, Ryo Kato, Atsushi Oyama, Teruya Nagahara, Masaya Iwamuro, Shigeru Horiguchi, Koichiro Tsutsumi, Mari Mandai, Tetsushige Mimura, Nozomu Wada, Yasuto Takeuchi, Kenji Kuwaki, Hideki Onishi, Shinichiro Nakamura, Masami Watanabe, Masakiyo Sakaguchi, Akinobu Takaki, Kazuhiro Nouso, Takahito Yagi, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Okada

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 32 ( 10 ) 1769 - 1777 2017.10

Language：English Publisher：WILEY

Background and Aim: Reduced expression in immortalized cells (REIC)/dickkopf-3 (Dkk-3) is a tumor suppressor gene that is downregulated in various cancers. In our previous study of prostate cancer, the REIC/Dkk-3-expressing adenoviral vector (Ad-REIC) was found to induce cancer-selective apoptosis. This study recently developed a novel super gene expression (SGE) system and used this system to re-construct an Ad-REIC vector, termed the Ad-SGE-REIC, to achieve more effective therapeutic outcomes. In this study, the therapeutic effects of Ad-SGE-REIC on hepatocellular carcinoma (HCC) was assessed.
Methods: Human HCC cell lines (HLE, Huh7, HepG2, HLF, SK-Hep1, and PLC), human HCC tissues, and mouse HCC cell line (Hepa1-6) were used in this study. REIC/Dkk-3 expression was assessed by immunoblotting and immunohistochemistry. The relative cell viability and the apoptotic effect were examined in vitro, and the anti-tumor effects of Ad-SGE-REIC treatment were analyzed in the mouse xenograft model. This study additionally assessed anti-tumor immunological effects on the immunocompetent mice.
Results: REIC/Dkk-3 expression was decreased in HCC cell lines and HCC tissues. Ad-SGE-REIC reduced cell viability and induced apoptosis in HCC cell lines (HLE and Huh7), inhibited tumor growth in the mouse xenograft model, and demonstrated in vivo anti-cancer immunostimulatory effects on the HCC cell line (Hepa1-6).
Conclusions: Ad-SGE-REIC treatment not only enhanced cell killing effects in vitro but also elicited significant therapeutic effects, with tumor growth suppression, in vivo. REIC/Dkk-3 gene therapy using Ad-SGE-REIC potentially represents an innovative new therapeutic tool for HCC.

DOI： 10.1111/jgh.13757

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Autoimmune hepatitis nationwide survey in Japan - subanalysis report

Teruko Arinaga-Hino, Atsushi Takahashi, Takuji Torimura, Hiromasa Ohira, Mikio Zeniya, Masanori Abe, Kaname Yoshizawa, Akinobu Takaki, Yoshiyuki Suzuki, Jong-Hon Kang, Nobuhiro Nakamoto, Tomoo Fujisawa, Atsushi Tanaka, Hajime Takikawa

HEPATOLOGY 66 194A - 194A 2017.10

Pruritus, dryness, fatigue and health-related quality of life in Japanese patients with primary biliary cholangitis

Minami Yagi, Atsushi Tanaka, Masanori Abe, Tadashi Namisaki, Hitoshi Yoshiji, Atsushi Takahashi, Hiromasa Ohira, Atsumasa Komori, Satoshi Yamagiwa, Kentaro Kikuchi, Tetsuya Yasunaka, Akinobu Takaki, Yoshiyuki Ueno, Akira Honda, Yasushi Matsuzaki, Hajime Takikawa

HEPATOLOGY 66 179A - 179A 2017.10

DAA治療によるSVR後発癌

竹内康人, 池田房雄, 和田望, 安中幸, 安中哲也, 大西秀樹, 中村進一郎, 白羽英則, 高木章乃夫, 岡田裕之

肝臓 58 ( Suppl.2 ) A578 - A578 2017.9

肝硬変に伴う軽症肺高血圧の病態分類と生体肝移植後生命予後に与える影響

大山淳史, 高木章乃夫, 安中哲也, 足立卓哉, 和田望, 竹内康人, 大西秀樹, 中村進一郎, 白羽英則, 信岡大輔, 吉田龍一, 楳田祐三, 篠浦先, 岡田裕之, 八木孝仁

肝臓 58 ( Suppl.2 ) A650 - A650 2017.9

若年成人の非アルコール性脂肪性肝疾患における遺伝子多型と白血球分画の検討

岩崎良章, 中山光, 池田房雄, 和田望, 安中哲也, 高木章乃夫, 岡田裕之

肝臓 58 ( Suppl.2 ) A636 - A636 2017.9

脾摘の功罪からみた生体肝移植における術前脾動脈塞栓術の意義

楳田祐三, 八木孝仁, 吉田龍一, 信岡大輔, 杭瀬崇, 國府島健, 熊野健二郎, 高木弘誠, 伏見卓郎, 友田健, 吉田真里, 加藤博也, 高木章乃夫, 藤原俊義

移植 52 ( 総会臨時 ) 333 - 333 2017.8

トルバプタンによる胸水腹水治療戦略肝硬変患者の体液貯留に対するトルバプタン効果予測因子としての酸化ストレスマーカーの有用性

足立卓哉, 高木章乃夫, 佐藤秀一, 大山淳史, 和田望, 安中幸, 竹内康人, 安中哲也, 大西秀樹, 池田房雄, 中村進一郎, 白羽英則, 岡田裕之

日本門脈圧亢進症学会雑誌 23 ( 3 ) 65 - 65 2017.8

肝硬変 : 肝硬変の合併症 : 合併症に負けないマネージメント (特集肝臓を診る : 肝臓病のキモ) -- (肝不全・肝硬変・肝細胞がん)

高木章乃夫, 安中哲也, 川野誠司, 岡田裕之

内科 = Internal medicine : 臨床雑誌 119 ( 6 ) 1173 - 1176 2017.6

Autoimmune hepatitis in Japan: trends in a nationwide survey

Atsushi Takahashi, Teruko Arinaga-Hino, Hiromasa Ohira, Takuji Torimura, Mikio Zeniya, Masanori Abe, Kaname Yoshizawa, Akinobu Takaki, Yoshiyuki Suzuki, Jong-Hon Kang, Nobuhiro Nakamoto, Tomoo Fujisawa, Koji Yonemoto, Atsushi Tanaka, Hajime Takikawa

JOURNAL OF GASTROENTEROLOGY 52 ( 5 ) 631 - 640 2017.5

Language：English Publisher：SPRINGER JAPAN KK

A nationwide survey of autoimmune hepatitis (AIH) patients was performed in Japan in 2015. The aims of this study were to elucidate the trends and characteristics of AIH in Japan, in addition to identifying differences in AIH between acute hepatitis and chronic hepatitis.
Questionnaires about patients with AIH diagnosed from 2009 to 2013 were sent to 437 hospitals or clinics with hepatology specialists.
A total of 1682 patients were enrolled. The mean age at diagnosis was 60.0 years, and 87.1 % of patients were female. Serum immunoglobulin G levels were high, peaking at 1.5-2.0 g/dL. Histological diagnoses of chronic hepatitis, acute hepatitis, and cirrhosis were seen in 79.6, 11.7, and 6.7 % of patients respectively. In addition to elevation of aminotransferase levels, the frequencies of emperipolesis and human leukocyte antigen (HLA)-DR2 positivity were higher in patients with acute hepatitis than in those with chronic hepatitis. Approximately 80 % of patients were treated with corticosteroids, and in 97.7 % of them, their condition improved. Steroid pulse therapy was more frequently given to patients with acute hepatitis than to those with chronic hepatitis.
In the present nationwide survey of AIH patients in Japan, patients with acute hepatitis had clinical features different from those of patients with chronic hepatitis.

DOI： 10.1007/s00535-016-1267-0

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