Faculty Profiles - TAKAKI Akinobu

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消化器疾患と自然免疫 C型肝炎ウイルス(HCV)構成遺伝子導入及びHCVタンパク貪食による樹状細胞サイトカイン産生能の変化

高木章乃夫, 岩崎良章, 白鳥康史

日本消化器病学会雑誌 103 ( 臨増総会 ) A59 - A59 2006.3

B型慢性肝炎の背景因子および治療目標による最適治療の選択

小橋春彦, 西田知弘, 白鳥康史, 辰川匡史, 庄司凡, 高木章乃夫, 岩崎良章, 坂口孝作

日本消化器病学会雑誌 103 ( 臨増総会 ) A233 - A233 2006.3

Long-term monitoring of platelet count, as a non-invasive marker of hepatic fibrosis progression and/or regression in patients with chronic hepatitis C after interferon therapy

H Taniguchi, Y Iwasaki, A Fujiwara, K Sakaguchi, A Moriya, PC Yu, A Takaki, SI Fujioka, H Shimornura, Y Shiratori

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 21 ( 1 ) 281 - 287 2006.1

Language：English Publisher：BLACKWELL PUBLISHING

Background: Platelet count has been shown to correlate with the hepatic fibrosis stage in chronic hepatitis C (CHC). The aim of the present study was to assess hepatic fibrosis progression or regression of CHC patients by long-term monitoring of the platelet count.
Methods: A total of 429 interferon (IFN)-treated CHC patients were studied. Follow-up data on the platelet count were collected every 6 months after IFN therapy. The IFN response was defined as follows: complete responders (CR, n = 121) demonstrating persistent clearance of serum hepatitis C virus (HCV) RNA; biochemical responders (BR, n = 94) demonstrating alanine aminotransferase (ALT) normalization for >= 6 months without eradication of HCV-RNA; and non-responder (NR, n = 214) demonstrating all other patterns.
Results: In comparison with the baseline level, mean platelet count increased in the CR group from 0.5 years after IFN therapy (for each point, P < 0.01), but significantly decreased in the NR group from I year after IFN therapy (for each point, P < 0.01). In the BR group, an increase in mean platelet count was observed from 0.5 to 3.5 years following IFN therapy (for each point, P < 0.01), followed by a gradual decrease.
Conclusion: An increase from baseline values in platelet count was observed, regardless of the presence of HCV-RNA, in both the CR and BR groups, suggesting the importance of ALT normalization in preventing hepatic fibrosis progression in IFN-treated CHC patients. (C) 2006 Blackwell Publishing Asia Pty Ltd.

DOI： 10.1111/j.1440-1746.2006.04201.x

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目でみる診断学 Wilson病のKayser-Fleischerリング

高木章乃夫, 白鳥康史

成人病と生活習慣病院 36,4,350-351 2006

Des-gamma-carboxy prothrombin is an autologous growth factor for hepatocellular carcinoma

H. Shiraha, M. Suzuki, T. Fujikawa, N. Ueda, N. Takaoka, Y. Nakanishi, A. Takaki, Y. Shiratori

JOURNAL OF HEPATOLOGY 44 S117 - S117 2006

Novel splicing variant of the vitamin K-dependent gamma-glutamyl carboxylase (GGCX) causes des-gamma-carboxyl prothrombin production in human hepatocellular carcinoma cell lines

N. Ueda, H. Shiraha, T. Fujikawa, M. Suzuki, N. Takanka, Y. Nakanishi, A. Takaki, Y. Shiratori

JOURNAL OF HEPATOLOGY 44 S109 - S110 2006

Novel splicing variant of the vitamin K-dependent Fa-glutamyl carboxylase (GGCX) in human des-gamma-carboxyl prothrombin producing hepatocellular carcinoma cell lines

N Ueda, H Shiraha, T Fujikawa, M Suzuki, N Takaoka, A Takaki, S Nakamura, Y Shiratori

HEPATOLOGY 42 ( 4 ) 528A - 528A 2005.10

Virus側と宿主側からみたC型慢性肝炎治療の将来像 C型肝炎ウイルス(HCV)構成遺伝子導入及びHCVタンパク貪食による樹状細胞機能の変化

高木章乃夫, 岩崎良章, 白鳥康史

肝臓 46 ( Suppl.2 ) A370 - A370 2005.9

Virus側と宿主側からみたC型慢性肝炎治療の将来像 C型肝炎ウイルス(HCV)構成遺伝子導入及びHCVタンパク貪食による樹状細胞機能の変化

高木章乃夫, 岩崎良章, 白鳥康史

日本消化器病学会雑誌 102 ( 臨増大会 ) A569 - A569 2005.9

C型肝炎ウイルス(HCV)構成遺伝子導入及びHCVタンパク貪食による樹状細胞(DC)表面マーカー及び機能の変化

高木章乃夫, 辰川匡史, 小池和子, 白羽英則, 岩崎良章, 白鳥康史

肝臓 46 ( Suppl.1 ) A225 - A225 2005.5

肝細胞癌における異常プロトロンビンの増殖制御機構

白羽英則, 鈴木真由美, 藤川達也, 高岡伸行, 上田直樹, 高木章乃夫, 白鳥康史

肝臓 46 ( Suppl.1 ) A141 - A141 2005.5

B型慢性肝炎発癌例と非発癌例の血清中HBV-DNA全長塩基配列の相違

辰川匡史, 高木章乃夫, 白羽英則, 小池和子, 藤岡真一, 岩崎良章, 白鳥康史

肝臓 46 ( Suppl.1 ) A190 - A190 2005.5

Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma

M Suzuki, H Shiraha, T Fujikawa, N Takaoka, N Ueda, Y Nakanishi, K Koike, A Takaki, Y Shiratori

JOURNAL OF BIOLOGICAL CHEMISTRY 280 ( 8 ) 6409 - 6415 2005.2

Language：English Publisher：AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

Des-gamma-carboxyl prothrombin (DCP) is a well recognized tumor marker for hepatocellular carcinoma (HCC). In the present study, we demonstrate that DCP has a mitogenic effect on HCC cell lines. Purified DCP stimulated DNA synthesis of Hep3B and SK-Hep-1 cells in a dose-dependent manner. DCP was found to bind with cell surface receptor Met causing Met autophosphorylation and also to activate STAT3 signaling pathway through Janus kinase 1. Luciferase gene reporter analysis showed that DCP induced STAT3-related transcription. Small interfering RNAs against both STAT3 and Met abrogated DCP-induced cell proliferation. DCP did not affect the mitogen-activated protein kinase pathway, Myc signaling pathway, or phosphoinositide 3-kinase/Akt pathway. Based on these results, we believe that DCP acts as an autologous mitogen for HCC cell lines. The Met-Janus kinase 1-STAT3 signaling pathway may be a major signaling pathway for DCP-induced cell proliferation.

DOI： 10.1074/jbc.M406714200

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【年齢・性差と肝胆膵疾患】年齢・性差と各種肝疾患 C型肝障害

平岡佐規子, 高木章乃夫, 白鳥康史

肝・胆・膵 51,2,199-204 2005

【ウイルス肝炎と肝移植】施設における現状と対策内科医より岡山大学病院において

高木章乃夫, 八木孝仁, 岩崎良章, 坂口孝作, 白鳥康史

今日の移植 18,2,213-215 2005

肝臓 C型肝炎ウイルス,病態,診断

高木章乃夫, 白鳥康史

Annual Review消化器2005巻 259-262 2005

【利尿薬の正しい使い方基礎と臨床】肝疾患と腹水

高木章乃夫, 白鳥康史

腎と透析 58,2,146-149 2005

Des-gamma-carboxy prothrombin is a potential autologous growth factor for hepatocellular carcinoma.

T Fujikawa, M Suzuki, H Shiraha, N Takaoka, N Ueda, Y Nakanishi, K Koike, A Takaki, Y Shiratori

HEPATOLOGY 40 ( 4 ) 602A - 603A 2004.10

B型慢性肝炎発癌例と非発癌例の血清中HBV DNA全長塩基配列の相違

辰川匡史, 高木章乃夫, 白羽英則, 小池和子, 藤岡真一, 岩崎良章, 白鳥康史

肝臓 45 ( Suppl.2 ) A451 - A451 2004.9

インターフェロンα8はα2よりもcaspaseを強く活性化し,抗癌剤による肝細胞癌株アポトーシスを誘導する

小池和子, 高木章乃夫, 辰川匡史, 白羽英則, 岩崎良章, 坂口孝作, 白鳥康史

肝臓 45 ( Suppl.2 ) A484 - A484 2004.9

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