Faculty Profiles - TAKAKI Akinobu

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肝炎の自然史-C型肝炎

高木章乃夫, 小池和子, 辰川匡史, 岩崎良章, 白鳥康史

臨床と研究 81,8,1233-1236 2004

病気と薬の説明ガイド2004－消化器疾患肝炎

高木章乃夫, 小池和子, 白鳥康史

薬局 55:999-1005 2004

急性肝不全の概念と分類の見直し－劇症肝炎に対する肝移植適応ガイドラインの問題点について

三宅康弘, 三好健司, 岡本良一, 森井和彦, 藤尾耕三, 大本昌樹, 池田弘, 小橋春彦, 牧野泰裕, 坂井宣之, 高口浩一, 荒木康之, 安東正晴, 喜田恵治, 高木章乃夫, 岩崎良章, 坂口孝作, 白鳥康史

消化器科 38(1) 2004

消化器疾患と免疫－基礎－肝臓の免疫装置と免疫担当細胞

高木章乃夫, 小池和子, 白鳥康史

消化器科 35(11) 2004

肝炎の臨床よりの問題臨床的諸問題の展開と今後の展望

高木章乃夫, 岩崎良章, 白鳥康史

肝疾患Review 2004 25-38 2004

肝炎の臨床よりの問題－臨床的諸問題の展開と今後の展望

高木章乃夫, 岩崎良章, 白鳥康史

肝疾患Review 25-38 2004

Effects of pulsing procedure of interleukin-12 in combination with interleukin-2 on the activation of peripheral blood lymphocytes derived from patients with hepatocellular carcinoma

T Sawayama, K Sakaguchi, T Senoh, T Ohta, M Nishimura, A Takaki, T Tsuji, Y Shiratori

ACTA MEDICA OKAYAMA 57 ( 6 ) 285 - 292 2003.12

Language：English Publisher：OKAYAMA UNIV MED SCHOOL

In patients with hepatocellular carcinoma (HCC), natural killer (NK) cell activity decreases significantly, and the reduced activity may be associated with the progression of HCC. In this study we evaluated the effects of pulsing with interleukin (IL)-2 and/or IL-12 on the activation of freshly isolated peripheral blood lymphocytes (PBL) derived from patients with HCC. PBL obtained from 9 HCC patients, 4 liver cirrhosis patients, and 9 normal subjects were cultured in the presence of IL-2 and/or IL-12. After 24h of incubation, the levels of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha presented in the supernatants were determined by enzyme-linked immunosorbent assay (ELISA). The IFN-gamma and TNF-alpha production of PBL pulsed by a combination of IL-2 and IL-12 was significantly higher than those of PBL stimulated by either IL-2 or IL-12 alone. The mRNA encoding perforin, granzyme B, as well as IFN-gamma and TNF-alpha, were markedly enhanced in PBL stimulated with a combination of IL-12 and IL-2. The pulsing procedure of IL-12 in combination with IL-2 resulted in the increase of IFN-gamma and TNF-alpha, and the expression of perforin and granzyme B mRNA in PBL obtained from HCC patients, as well as in those obtained from normal subjects. These results indicate that adoptive immunotherapy based on PBL pulsed with a combination of IL-2 and IL-12 may be a promising adjunctive strategy for HCC treatment.

DOI： 10.18926/AMO/32813

Web of Science

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紫外線照射にて蛍光赤血球を認めた骨髄性プロトポルフィリンの1例

庄司凡, 藤岡真一, 守屋昭男, 寺田亮, 朴成郁, 高木章乃夫, 岩崎良章, 白鳥康史

岡山済生会総合病院雑誌 35 104 - 105 2003.12

インターフェロンαサブタイプによる肝癌細胞株アポトーシス誘導効果の相違

高木章乃夫, 小池和子, 白羽英則, 岩崎良章, 坂口孝作, 稲葉二朗, 窪田規一, 白鳥康史

日本免疫学会総会・学術集会記録 33 331 - 331 2003.11

Interferon alpha 8 and 2 show differential activation of apoptosis pathway and growth factor pathway in human hepatoma cell lines.

A Takaki, K Koike, H Shiraha, Y Iwasaki, K Sakaguchi, N Inaba, K Kubota, Y Shiratori

HEPATOLOGY 38 ( 4 ) 406A - 406A 2003.10

C型肝炎ウイルス構成遺伝子導入による樹状細胞HLA及びCostimulatory molecule発現の変化についての検討

高木章乃夫, 小池和子, 白羽英則, 岩崎良章, 中山睿一, 白鳥康史

肝臓 44 ( Suppl.2 ) A433 - A433 2003.9

Des-gamma-carboxy prothrombin is an autocrine mitogen for hepatocellular carcinoma

M Suzuki, H Shiraha, T Fujikawa, N Takaoka, A Takaki, Y Nakanishi, N Ueda, K Koike, K Sakaguchi, Y Shiratori

GASTROENTEROLOGY 124 ( 4 ) A285 - A285 2003.4

インターフェロンαサブタイプによる肝癌細胞アポトーシス誘導能の相違と,細胞内情報伝達系及びアポトーシス関連遺伝子の変化の関連

高木章乃夫, 小池和子, 白羽英則, 岩崎良章, 坂口孝作, 白鳥康史

肝臓 44 ( Suppl.1 ) A168 - A168 2003.4

インターフェロンαサブタイプによる肝癌細胞アポトーシス誘導能の相違インターフェロンα2とα8で異なる細胞内情報伝達系とアポトーシス関連遺伝子の連係

高木章乃夫, 小池和子, 白羽英則, 岩崎良章, 白鳥康史

日本消化器病学会雑誌 100 ( 臨増総会 ) A150 - A150 2003.3

C型肝炎治療の実際と展望

白鳥康史, 医歯学総合研究科, 消化器肝臓感染症内科学, 岩崎良章, 小林功幸, 高木章乃夫, 坂口孝作

日本医事新報 1-10 2003

【消化器疾患と免疫】基礎肝臓の免疫装置と免疫担当細胞

高木章乃夫, 医歯学総合研究科, 消化器肝臓感染症内科, 小池和子, 白鳥康史

現代医療 35,11,2504-2508 2003

【内科キーワード2003】肝・胆・膵インターフェロン治療と肝線維化緩解

坂口孝作, 消化器肝臓感染症内科, 高木章乃夫, 河本博文, 白鳥康史

内科 91,6,1074 2003

約25年の経過で肝硬変に進展した体質性黄疸の一例

藤田英行, 医学部, 学科, 藤岡真一, 寺田亮, 馬場伸介, 中西豊, 朴成郁, 高木章乃夫, 岩崎良章, 山本和秀, 白鳥康史

日本消化器内視鏡学会雑誌 2003

【ウイルス肝炎診療update】 HCVの構造と研究の進歩 HCVと免疫

高木章乃夫, 消化器肝臓感染症内科学, 小池和子, 白鳥康史

臨床医 29,5,633-635 2003

A case of focal segmental glomerulosclerosis (FSGS) complicated with chronic hepatitis B and treated with steroid and LDL apheresis.

TAKAKI Akinobu, NAKATSUKA Atsuko, SATOU Chikage, IWATA Yasuyoshi, IKEDA Hiroshi, FUKUSHIMA Masaki

Jpn J Nephrol 44 ( 8 ) 806 - 812 2002

Language：Japanese Publisher：Japanese Society of Nephrology

A 52-year-old man was admitted to our hospital because of nephrotic syndrome. He had been monitored at our outpatient clinic for chronic hepatitis B, and had experienced histologically proven minimal change nephrotic syndrome at the ages of 40 and 51 years. Because of HBsAg positivity in his serum, steroid therapy was withheld in his earlier episodes and he recovered from nephrotic syndrome spontaneously. However, in the most recent episode the nephrotic syndrome was found difficult to control and the findings of renal biopsy showed FSGS, which is not expected in HBV-associated nephropathy. Finally, prednisolone was administered at the dose of 40 mg/day for four weeks, after which the dose was tapered. LDL apheresis was also administered three times because of the patient's incomplete response to prednisolone. His proteinuria was reduced from>10 g/day to<1 g/day, but the ALT levels and HBsAg titer increased. With stronger neominophagen C induction and very careful tapering of glucocorticoid, ALT levels and the HBsAg titer decreased. During the two-year period since the induction of glucocor ticoid therapy, urinary protein excretion has been maintained at less than 1 g/gcr, and ALT levels and HBsAg titer have not increased. We conclude that attention must be paid to dose modification of steroid therapy and strategies without immunosuppressive agents such as LDL apheresis should be considered in the case of treatment of nephrotic syndrome with HB virus.

DOI： 10.14842/jpnjnephrol1959.44.806

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