研究者詳細 - 飯田　征二

論文 - 飯田　征二

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スメグマ菌におけるメチオニン関連遺伝子欠損株作製とその解析

橋本和樹, 飯田征二, 大原直也

岡山歯学会雑誌 38 ( 1 ) 1 - 14 2019年6月

Intermittent parathyroid hormone 1–34 induces oxidation and deterioration of mineral and collagen quality in newly formed mandibular bone 国際誌

Yohsuke Yoshioka, Eiki Yamachika, Makoto Nakanishi, Tadashi Ninomiya, Sho Akashi, Sei Kondo, Norifumi Moritani, Yasuhiro Kobayashi, Tatsuo Fujii, Seiji Iida

Scientific Reports 9 ( 1 ) 8041 - 8041 2019年5月

担当区分：最終著者記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Intermittent parathyroid hormone (PTH) administration is known to promote bone healing after surgical procedures. However, the mechanism and influence of PTH on the mineral and collagen quality of the jaw are not well understood. Most studies have focused on analyzing the bone density and microstructure of the mandible, and have insufficiently investigated its mineral and collagen quality. Oxidative stress activates osteoclasts, produces advanced glycation end products, and worsens mineral and collagen quality. We hypothesized that PTH induces oxidation and affects the mineral and collagen quality of newly formed mandibular bone. To test this, we examined the mineral and collagen quality of newly formed mandibular bone in rats administered PTH, and analyzed serum after intermittent PTH administration to examine the degree of oxidation. PTH administration reduced mineralization and worsened mineral and collagen quality in newly formed bone. In addition, total anti-oxidant capacity in serum was significantly decreased and the oxidative-INDEX was increased among PTH-treated compared to vehicle-treated rats, indicating serum oxidation. In conclusion, intermittent administration of PTH reduced mineral and collagen quality in newly formed mandibular bone. This effect may have been induced by oxidation.

DOI： 10.1038/s41598-019-44389-8

PubMed

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その他リンク： https://www.nature.com/articles/s41598-019-44389-8

人工呼吸管理中に浮腫による巨舌を呈した1例

人工呼吸管理中に浮腫による巨舌を呈した, 石邊紀章, 澤木康一, 藤田祐貴, 岡崎文彦, 佐藤亜希, 吉岡洋祐, 中野誠, 松村達志, 山近英樹, 飯田征二

広島市立広島市民病院医誌 35 ( 1 ) 65 - 68 2019年3月

歯科矯正用アンカースクリューによりデンタルディコンペンセーションを図った骨格性III級症例に対する外科的矯正治療査読

田中智代, 矯正歯科, 村上隆, 森谷徳文, 松村達志, 飯田征二, 上岡寛

日本顎変形症学会雑誌 29 ( 4 ) 295 - 303 2019年

二卵性双生児にみられた22q11.2欠失症候群

有村友紀, 松村達志, 水谷雅英, 植松彩, 松井裕一, 岡田亜由美, 田畑光康, 明石翔, 中川敦子, 飯田征二

岡山歯学会雑誌 37 ( 2 ) 37 - 42 2018年12月

記述言語：日本語出版者・発行元：岡山歯学会

二卵性双生児で、一人は粘膜下口蓋裂、一人は先天性鼻咽腔閉鎖不全症を伴った22q11.2欠失症候群の症例を報告した。二卵性双生児の兄:5歳時に鼻咽腔閉鎖不全を指摘され、当院耳鼻咽喉科に紹介となった。特異的顔貌を認めたため、染色体検査を行い22q11.2欠失症候群と診断された。粘膜下口蓋裂に対して口蓋形成術(Furlow法)を施行し、その後は定期的に言語訓練を行うこととなった。二卵性双生児の弟:5歳時に鼻咽腔閉鎖不全を指摘され、兄とともに当院耳鼻咽喉科に紹介となった。軟口蓋挙上装置を装着し、言語訓練を行った。一旦来院が途絶えていたが再来院され、言語訓練の重要性を十分に説明した。その後は定期的に言語訓練を施行している。

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A3 adenosine receptor agonist attenuates neuropathic pain by suppressing activation of microglia and convergence of nociceptive inputs in the spinal dorsal horn 査読

Ryuji Terayama, Mitsuyasu Tabata, Kotaro Maruhama, Seiji Iida

Experimental Brain Research 236 ( 12 ) 3203 - 3213 2018年12月

Dental management of unilateral multiple impacted primary teeth

Yuki Matsumi, Yuko Morikawa, Eri Yoshida, Setsuyo Morimoto, Sho Yoshida, Tatsushi Matsumura, Seiji Iida, Yukiko Takashima, Shuhei Naka, Michiyo Matsumoto-Nakano

PEDIATRIC DENTAL JOURNAL 28 ( 3 ) 119 - 124 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

Impacted primary teeth can be caused by odontogenic tumors such as odontomas, cystic diseases such as dentigerous and eruption cysts, and fibrous hyperplasia of the gingiva, while elimination of those causes reportedly results in normal eruption of primary teeth. We describe the course of a child from the age of 1 year until 4 years 10 months who had primary tooth eruption failure and was treated with dental methods. Although primary teeth expected to spontaneously erupt were followed, there were several on the left side that remained unerupted. We performed a left maxillary and mandibular gingivectomy to closely examine the cause of eruption delay and tooth germ dislocation, as well as attempt to induce eruption of the primary teeth. Based on histopathological results, the diagnosis was fibroma. Surgical procedures did not result in clear improvement of eruption failure. In order to improve masticatory function and aesthetics, the child was fixed with an artificial denture for all primary teeth not expected to erupt. (C) 2018 Japanese Society of Pediatric Dentistry. Published by Elsevier Ltd. All rights reserved.

DOI： 10.1016/j.pdj.2018.09.002

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Efficacy of Maxillary Anterior Segmental Distraction Osteogenesis in Patients With Cleft Lip and Palate. 査読国際誌

Chihiro Tanikawa, Kae Hirata, Tomonao Aikawa, Jun Maeda, Mikihiko Kogo, Seiji Iida, Takashi Yamashiro

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 55 ( 10 ) 1375 - 1381 2018年11月

記述言語：英語

OBJECTIVES: To evaluate the effects of maxillary anterior segmental distraction osteogenesis (MASDO) in patients with cleft lip and palate (CLP) and to identify risk factors for increased relapse. DESIGN: A retrospective study. PATIENTS: Thirty-one Japanese patients with CLP who underwent MASDO were eligible for study inclusion. MAIN OUTCOME MEASURES: We evaluated lateral cephalograms obtained before (T1), at 3 months (T2), and at 1 year (T3) after MASDO, and measured changes from T1 to T2 (δT1T2), from T2 to T3 (δT2T3), and from T1 to T3 (δT1T3). We also evaluated the risk factors associated with an increased relapse. RESULTS: Overall (δT1T3), MASDO improved retrusion of the maxilla. We measured a significant advancement (6.1 mm) of the anterior maxillary segment in δT1T2 (A-McNamara classification) and increases in the overjet and the SNA, ANB, and nasolabial angles. However, skeletal relapse was evident in δT2T3, and the median percentage of relapse was 10%. To explore the risk factors, we subdivided patients with a δT1T2 of >5 mm into 2 groups based on the percentage of relapse (>15% vs ≤15%). There were significant differences between these groups in the vertical positions of the anterior nasal spine and point A, and the angle formed by the SN and palatal planes (SNPP), suggestive of intraoperative counterclockwise rotation of the maxilla. CONCLUSIONS: MASDO is effective for correcting midfacial deficiencies, but counterclockwise rotation of the maxilla during surgery may cause relapse.

DOI： 10.1177/1055665618758692

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Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats

Y. Yoshioka, E. Yamachika, M. Nakanishi, T. Ninomiya, K. Nakatsuji, Y. Kobayashi, T. Fujii, S. Iida

British Journal of Oral and Maxillofacial Surgery 56 ( 8 ) 732 - 738 2018年10月

Molecular alterations of newly formed mandibular bone caused by zoledronate

Y. Yoshioka, E. Yamachika, M. Nakanishi, T. Ninomiya, K. Nakatsuji, M. Matsubara, N. Moritani, Y. Kobayashi, T. Fujii, S. Iida

International Journal of Oral and Maxillofacial Surgery 47 ( 9 ) 1206 - 1213 2018年9月

Peripheral neuropathy arose in the trigeminal nerve during chemotherapy with docetaxel: A report of two cases

Yuki Fujita, Shunsuke Hino, Koichi Sawaki, Makoto Nakano, Takahiro Kaneko, Norio Horie, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 30 ( 4 ) 359 - 364 2018年7月

PTH間歇投与による下顎新生骨の骨質変化ラマン分光法を用いた骨質解析

吉岡洋祐, 山近英樹, 中西真, 二宮禎, 明石翔, 松原正和, 森谷徳文, 小林泰浩, 藤井達生, 飯田征二

日本骨形態計測学会雑誌 28 ( 2 ) S109 - S109 2018年5月

Odontoma associated with unerupted primary tooth in primary dentition - Three cases

Yukiko Takashima, Yuko Morikawa, Atsushi Takagi, Yuki Matsumi, Tatsushi Matsumura, Seiji Iida, Shuhei Naka, Michiyo Matsumoto-Nakano

PEDIATRIC DENTAL JOURNAL 28 ( 1 ) 19 - 24 2018年4月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCIENCE BV

Odontomas are generally encountered in permanent dentition and rarely seen in primary dentition. These lesions are regarded as essentially benign, though they often cause disturbances in eruption of the associated tooth. We present clinical findings and management of 3 cases of odontomas that occurred in primary dentition, including a 3-year-old girl referred for examination of an unerupted left upper primary canine, a 6-year-old boy with an unerupted left lower second primary molar, and a 5-year-old girl who was presented with an unerupted right upper second primary molar. In all cases, periapical and panoramic radiography revealed a radio-opaque mass surrounded by a narrow radiolucent space located above the crown of the unerupted tooth. Each was diagnosed as a compound odontoma interfering with eruption of a primary tooth and surgical removal was performed under general anesthesia for all patients, with the final diagnosis based on histological findings. Following surgery, the primary canine in Case 1 spontaneously erupted, while a space maintenance appliance was applied in Case 2 and 3. It is important to recognize that an odontoma can appear in primary dentition, though the incidence is quite low. Early detection and removal of an odontoma associated with an impacted primary tooth is necessary for optimal dentition. (C) 2017 Published by Elsevier Ltd on behalf of Japanese Society of Pediatric Dentistry.

DOI： 10.1016/j.pdj.2017.10.001

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Differential induction of c-Fos and phosphorylated ERK by a noxious stimulus after peripheral nerve injury

Mitsuyasu Tabata, Ryuji Terayama, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto

International Journal of Neuroscience 128 ( 3 ) 208 - 218 2018年3月

Metabolic regulation of the CCN family genes by glycolysis in chondrocytes. 国際誌

Sho Akashi, Takashi Nishida, Abdellatif El-Seoudi, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of cell communication and signaling 12 ( 1 ) 245 - 252 2018年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

The CCN family consists of 6 genes in the mammalian genome and produces multifunctional proteins involved in a variety of biological processes. Recent reports indicate the profound roles of CCN2 in energy metabolism in chondrocytes, and Ccn2 deficiency is known to alter the expression of 2 other family members including Ccn3. However, almost nothing is known concerning the regulation of the CCN family genes by energy metabolism. In order to gain insight into this critical issue, we initially and comprehensively evaluated the effect of inhibition of glycolysis on the expression of all of the CCN family genes in chondrocytic cells. Upon the inhibition of a glycolytic enzyme, repression of CCN2 expression was observed, whereas CCN3 expression was conversely induced. Similar repression of CCN2 was conferred by the inhibition of aerobic ATP production, which, however, did not induce CCN3 expression. In contrast, glucose starvation significantly enhanced the expression of CCN3 in those cells. The results of a reporter gene assay using a molecular construct containing a CCN3 proximal promoter revealed a dose-dependent induction of the CCN3 promoter activity by the glycolytic inhibitor in chondrocytic cells. These results unveiled a critical role of glycolytic activity in the regulation of CCN2 and CCN3, which activity mediated the mutual regulation of these 2 major CCN family members in chondrocytes.

DOI： 10.1007/s12079-017-0420-8

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The influence of zoledronate and teriparatide on gamma delta T cells in mice 査読国際誌

Yamachika Eiki, Matsui Yuichi, Matsubara Masakazu, Matsumura Tatsushi, Nakata Naoki, Moritani Norifumi, Ikeda Atsushi, Tsujigiwa Hidetsugu, Ohara Naoya, Iida Seiji

JOURNAL OF DENTAL SCIENCES 12 ( 4 ) 333 - 339 2017年12月

The Incidence of Oral and Oropharyngeal Cancers in Betel Quid-Chewing Populations in South Myanmar Rural Areas

Nobuyoshi Mizukawa, Swe Swe Win, Zaw Moe Thein, Moe Thida Htwe, Yohsuke Yoshioka, Yoshihiro Kimata, Seiji Iida, Myo Khin, Shigeru Okada, Than Sein

Act Medica OKAYAMA 71 ( 6 ) 519 - 524 2017年12月

多数の静脈石を認めた咬筋内静脈奇形の1例

藤田佑貴, 水谷雅英, 有村友紀, 池田篤司, 柳文修, 飯田征二

日本口腔外科学会雑誌 63 ( 11 ) 593 - 597 2017年11月

記述言語：日本語出版者・発行元：(公社)日本口腔外科学会

症例は21歳女性で、13年前に左側頬部の腫瘤を自覚したが確定診断には至らなかった。左側頬部に鈍痛を覚えるようになり、腫瘤の増大を認めた。左側頬粘膜は表面正常で、触診にて咬筋相当部に可動性で軽度の圧痛を伴う30mm大の骨様硬の病変を触知した。単純CT画像では、左側狡筋は右側と比較し腫大し、内部に長径22mm大、外形不整な高吸収域を認めた。病変内部に長径3〜6mm大の複数の類円形石灰物を認めた。造影CT画像では、高吸収域に不均一な造影効果を認め、造影性の高い領域では血管腔と同程度の高い造影性を示した。腫瘤内石灰化物の多くは内部に核を有し、層板状構造に近い性状であった。MRI所見では、病変内部はT1強調画像では低信号から筋と同程度の不均一な信号強度、T2強調画像では低信号から高信号の不均一な信号強度を呈し、石灰化物に相当する部分はほぼ無信号を呈した。全身麻酔下で口腔内より腫瘤の摘出術を施行した。現在、術後3年経過しているが、再発はなく経過良好である。摘出標本の病理組織学的診断は静脈石を伴った静脈奇形であった。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2017&ichushi_jid=J01073&link_issn=&doc_id=20171130350014&doc_link_id=10.5794%2Fjjoms.63.593&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.63.593&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Rapid occurrence of left ventricular thrombus associated with platinum-based chemotherapy plus cetuximab for the treatment of metastatic squamous cell carcinoma of the head and neck: A case report. 国際誌

Atsushi Ikeda, Eiki Yamachika, Masahide Mizutani, Masakazu Matsubara, Norifumi Moritani, Kazuki Nakatsuji, Seiji Iida

Molecular and clinical oncology 7 ( 5 ) 833 - 836 2017年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

Platinum-based chemotherapy plus cetuximab represents the first-line treatment for recurrent or metastatic squamous cell carcinoma of the head and neck. The most common adverse events associated with cetuximab are infusion reactions and skin reactions, and a risk of venous thromboembolic events has also recently been reported in association with cetuximab. It is well known that thrombosis is a common complication of malignancy, and represents the second most frequent cause of mortality in cancer patients. The present study reports the case of a 79-year-old man who presented with lung and liver metastases from tongue squamous cell carcinoma, for which platinum-based chemotherapy plus cetuximab was administered. After 1 cycle, the patient showed rapid growth of a left ventricular (LV) thrombus, despite ongoing antiplatelet therapy for an old myocardial infarction. Anticoagulant therapy was administered to treat the LV thrombus, which resolved within 1 week. To the best of our knowledge, this represents the first reported case of rapidly occurring LV thrombus associated with platinum-based chemotherapy plus cetuximab. Platinum-based chemotherapy plus cetuximab may be associated with a higher risk of embolic thrombus.

DOI： 10.3892/mco.2017.1393

PubMed

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骨吸収抑制薬関連顎骨壊死に由来した非クロストリジウム性ガス壊疽の1例

松原正和, 石田展久, 池田篤司, 山近英樹, 明石翔, 飯田征二

63 ( 10 ) 506 - 511 2017年10月

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