研究者詳細 - 飯田　征二

論文 - 飯田　征二

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Role of oral sensory and serotonergic neurons in dopamine-induced tongue movement in rat

Takeshi Harada, Seiji Iida, Yoshiki Inada, Susumu Tanaka, Yoshinosuke Hamada, Mikihiko Kogo

Nano Biomedicine 12 ( 2 ) 53 - 60 2020年

掲載種別：研究論文（学術雑誌）

Background: Oral dyskinesia is a condition in which oral organs exhibit involuntary movements. The aim of this study was to determine the contribution of oral sensation to the control of oral dyskinesia using an animal model that exhibits vacuous tongue movements after systemic administration of dopamine (DA) agonists. Methods: Adult male Sprague-Dawley rats were used in all experiments. Tongue movement was elicited in a freely moving rat model by systemic administration of a mixture of the D1 receptor agonist SKF38393 and the D2 receptor agonist quinpirole. The number of tongue protrusions was calculated from electrical myographic data obtained from the genioglossal muscle. Extracellular concentrations of DA and serotonin (5-HT) in the nucleus accumbens were determined using in vivo microdialysis. To investigate the effects of oral sensation on vacuous tongue movement, deafferentation of the palatal mucosa was performed, and the above experiments were repeated. Results: The hyperactivity of tongue protrusion induced by administration of SKF38393 and quinpirole was significantly inhibited by palatal deafferentation. Palatal deafferentation also significantly reduced the increase in extracellular 5-HT concentration in the nucleus accumbens produced by administration of DA agonists. Conclusions: These results support the important contribution of oral sensation to vacuous tongue protrusion in a rat model of oral dyskinesia.

DOI： 10.11344/nano.12.53

Scopus

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Histological differences related to autophagy in the minor salivary gland between primary and secondary types of Sjögren's syndrome. 国際誌

Hitomi Ono-Minagi, Tsutomu Nohno, Kiyofumi Takabatake, Takehiro Tanaka, Takayuki Katsuyama, Kohta Miyawaki, Jun Wada, Soichiro Ibaragi, Seiji Iida, Tadashi Yoshino, Hitoshi Nagatsuka, Takayoshi Sakai, Hideyo Ohuchi

BMC oral health 24 ( 1 ) 1099 - 1099 2024年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Some forms of Sjögren's syndrome (SS) follow a clinical course accompanied by systemic symptoms caused by lymphocyte infiltration and proliferation in the liver, kidneys, and other organs. To better understand the clinical outcomes of SS, here we used minor salivary gland tissues from patients and examine their molecular, biological, and pathological characteristics. A retrospective study was performed, combining clinical data and formalin-fixed paraffin-embedded (FFPE) samples from female patients over 60 years of age who underwent biopsies at Okayama University Hospital. We employed direct digital RNA counting with nCounter® and multiplex immunofluorescence analysis with a PhenoCycler™ on the labial gland biopsies. We compared FFPE samples from SS patients who presented with other connective tissue diseases (secondary SS) with those from stable SS patients with symptoms restricted to the exocrine glands (primary SS). Secondary SS tissues showed enhanced epithelial damage and lymphocytic infiltration accompanied by elevated expression of autophagy marker genes in the immune cells of the labial glands. The close intercellular distance between helper T cells and B cells positive for autophagy-associated molecules suggests accelerated autophagy in these lymphocytes and potential B cell activation by helper T cells. These findings indicate that examination of FFPE samples from labial gland biopsies can be an effective tool for evaluating molecular histological differences between secondary and primary SS through multiplexed analysis of gene expression and tissue imaging.

DOI： 10.1186/s12903-024-04869-4

PubMed

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Migrationにより下顎骨下縁より歯根が突出した異所性埋伏智歯の一例

永田裕樹, 天野克比古, 武田斉子, 中辻和樹, 飯田征二

日本口腔科学会雑誌 73 ( 2 ) 106 - 107 2024年9月

【埋伏歯について】埋伏歯・萠出障害の歯の診断と治療

飯田征二

小児歯科臨床 29 ( 8 ) 28 - 37 2024年8月

The Endoscopic Removal of a Detached Dental Implant Cap in the Maxillary Sinus During the Waiting Period: A Case Report. 国際誌

Katsuhiko Amano, Chiaki Nishizawa, Yohei Maeda, Susumu Tanaka, Seiji Iida

Cureus 16 ( 6 ) e63243 2024年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Displacement of dental implants into the maxillary sinus is one of the common dental complications. However, it is rare that dental implants cause the displacement of multiple components due to separation. Here, we describe an unusual case of a 43-year-old man who had a missing implant in the maxillary sinus after an implant procedure. There was a two-week waiting period before we performed the removal during which the cap had unexpectedly separated from the body and freely moved into the ostium by sinus activity. The body was independently extracted intraorally. The remaining cap was secondly removed by utilizing nasal endoscopy. There were no complications in the postoperative period and the patient reported no symptoms of sinusitis after two months of follow-up. We experience unexpected events in the course of treating a displaced implant into the maxillary sinus. Our case report may provide several learning points for the removal of a missing implant.

DOI： 10.7759/cureus.63243

PubMed

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Double-faced CX3CL1 enhances lymphangiogenesis-dependent metastasis in an aggressive subclone of oral squamous cell carcinoma. 国際誌

Htoo Shwe Eain, Hotaka Kawai, Masaaki Nakayama, May Wathone Oo, Toshiaki Ohara, Yoko Fukuhara, Kiyofumi Takabatake, Quisheng Shan, Yamin Soe, Kisho Ono, Keisuke Nakano, Nobuyoshi Mizukawa, Seiji Iida, Hitoshi Nagatsuka

JCI insight 9 ( 10 ) 2024年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

Because cancer cells have a genetically unstable nature, they give rise to genetically different variant subclones inside a single tumor. Understanding cancer heterogeneity and subclone characteristics is crucial for developing more efficacious therapies. Oral squamous cell carcinoma (OSCC) is characterized by high heterogeneity and plasticity. On the other hand, CX3C motif ligand 1 (CX3CL1) is a double-faced chemokine with anti- and pro-tumor functions. Our study reported that CX3CL1 functioned differently in tumors with different cancer phenotypes, both in vivo and in vitro. Mouse OSCC 1 (MOC1) and MOC2 cells responded similarly to CX3CL1 in vitro. However, in vivo, CX3CL1 increased keratinization in indolent MOC1 cancer, while CX3CL1 promoted cervical lymphatic metastasis in aggressive MOC2 cancer. These outcomes were due to double-faced CX3CL1 effects on different immune microenvironments indolent and aggressive cancer created. Furthermore, we established that CX3CL1 promoted cancer metastasis via the lymphatic pathway by stimulating lymphangiogenesis and transendothelial migration of lymph-circulating tumor cells. CX3CL1 enrichment in lymphatic metastasis tissues was observed in aggressive murine and human cell lines. OSCC patient samples with CX3CL1 enrichment exhibited a strong correlation with lower overall survival rates and higher recurrence and distant metastasis rates. In conclusion, CX3CL1 is a pivotal factor that stimulates the metastasis of aggressive cancer subclones within the heterogeneous tumors to metastasize, and our study demonstrates the prognostic value of CX3CL1 enrichment in long-term monitoring in OSCC.

DOI： 10.1172/jci.insight.174618

PubMed

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当科における口唇口蓋裂症例に対する上顎骨骨延長術の応用

有村友紀, 天野克比古, 中辻和樹, 永田裕樹, 加藤壮真, 植田紘貴, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 136 - 136 2024年5月

術前後にナゾメーターで鼻咽腔閉鎖機能を評価し上顎骨延長術により反対咬合の改善を行った口蓋裂症例の一例

植田紘貴, 岡直毅, 中西泰之, 有村友紀, 飯田征二, 上岡寛

日本顎変形症学会雑誌 34 ( 2 ) 137 - 137 2024年5月

4切歯を含む上顎歯槽骨切り術によって歯列不正を改善した2症例

中辻和樹, 天野克比古, 谷本裕子, 河野加奈, 有村友紀, 永田裕樹, 加藤壮真, 上岡寛, 飯田征二

日本顎変形症学会雑誌 34 ( 2 ) 191 - 191 2024年5月

Sturge-Weber syndrome with cemento-ossifying fibroma in the maxilla and giant odontoma in the mandible: A case report

Aki Sato, Hisako Furusho, Tatsushi Matsumura, Makoto Nakano, Koichi Sawaki, Yohsuke Yoshioka, Sho Akashi, Mutsumi Miyauchi, Nobuyoshi Mizukawa, Seiji Iida

Heliyon 10 ( 8 ) e29445 - e29445 2024年4月

重度開口障害により口蓋裂未手術のロバン・シークエンス症例で栓塞子を併用して矯正歯科治療を行った一例査読

穴田理嵯, 植田紘貴, 古西隆之, 中川敦子, 有村友紀, 飯田征二, 上岡寛

日本口蓋裂学会雑誌 49 ( 2 ) 154 - 154 2024年4月

光学印象で前方骨片の可動性に配慮し無圧印象することで上顎骨前方部骨延長(MASDO)術後の安定を図った一例査読

竹本史子, 植田紘貴, 中西泰之, 西谷悠希, 兵藤藍子, 有村友紀, 飯田征二, 上岡寛

日本口蓋裂学会雑誌 49 ( 2 ) 153 - 153 2024年4月

扇型の上顎骨拡大により正常被蓋を獲得した片側性唇顎口蓋裂の3症例

西谷悠希, 有村友紀, 天野克比古, 兵藤藍子, 植田紘貴, 河野加奈, 大久保香織, 竹本史子, 上岡寛, 飯田征二

日本口蓋裂学会雑誌 49 ( 2 ) 161 - 161 2024年4月

放射線性顎骨壊死18例における感染源と周術期口腔管理の効果についての検討

武田斉子, 水川展吉, 田村庄平, 中田靖章, 天野克比古, 浅海淳一, 飯田征二

岡山歯学会雑誌 42 ( 2 ) 23 - 32 2023年12月

記述言語：日本語出版者・発行元：岡山歯学会

当科で治療を行った放射線性顎骨壊死(ORN)について、発症原因となった歯科疾患を中心に検討し、周術期口腔管理の有無による臨床像の違いも評価した。2013～2021年にORNと診断された18例(男性12例、女性6例)を対象とした。口腔管理群8例では感染源が歯周炎に関わる症例はなく、智歯周囲炎3例、咬合性外傷4例、感染源不明1例であった。非管理群10例では辺緑性歯周炎2例、根尖性歯周炎が3例、智歯周囲炎2例、義歯性潰瘍1例、感染源不明2例であった。保存療法のみ行ったのは8例であり、保存療法を行ったものの悪化を認めたため高気圧酸素療法を行ったのは3例、最終的に外科治療を行ったのは7例であった。ORNの予後や各治療方法の効果においては管理群と非管理群で明らかな違いはなかった。

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充実部と嚢胞部が混在し診断に苦慮したエナメル上皮腫の1例

舩橋洋志, 天野克比古, 岩本悠希, 長尾有里, 高畠清文, 永田裕樹, 飯田征二

日本口腔科学会雑誌 72 ( 4 ) 258 - 258 2023年12月

歯磨剤が含有するSLSに起因したと考えられた口腔粘膜剥離の1例

西谷悠希, 天野克比古, 武田斉子, 有村友紀, 田村庄平, 中辻和樹, 永田裕樹, 飯田征二

岡山歯学会雑誌 42 ( 2 ) 69 - 69 2023年12月

左側下顎頭内側に周辺性骨腫を有する顔面非対称患者に骨腫切除と外科的矯正治療を行った1例

河野加奈, 竹本史子, 太田明美, 森谷徳文, 飯田征二, 上岡寛

日本矯正歯科学会大会プログラム・抄録集 82回 257 - 257 2023年11月

開窓術により治療した舌下型類皮囊胞の1例査読

武田斉子, 田村庄平, 天野克比古, 水川展吉, 高畠清文, 飯田征二

日本口腔外科学会 69 ( 10 ) 475 - 480 2023年10月

担当区分：最終著者記述言語：日本語出版者・発行元：(公社)日本口腔外科学会

53歳女性。近在歯科を受診した際に口底部の腫脹を指摘され、当院へ紹介となった。口腔内所見では口底正中部粘膜下に25×25mm大の可動性を有する無痛性で弾性軟の類球形の腫瘤が認められた。また、造影CTでは口底正中からオトガイ舌骨筋上にかけて内部不均一な低吸収域の24×23×22mmの腫瘤が認められた。MR画像所見も踏まえて、本症例は脂肪腫を疑い、局所麻酔下に生検を行ったところ、病理組織学的に舌下型類皮嚢胞(DC)と診断された。DCは開窓術により縮小し、DCの残遺病変を摘出することで治癒することができた。

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20231027410005&doc_link_id=10.5794%2Fjjoms.69.475&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.475&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Expression and function of CCN2-derived circRNAs in chondrocytes

Soma Kato, Kazumi Kawata, Takashi Nishida, Tomomi Mizukawa, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of Cell Communication and Signaling 2023年9月

掲載種別：研究論文（学術雑誌）出版者・発行元：Springer Science and Business Media LLC

Abstract

Cellular communication network factor 2 (CCN2) molecules promote endochondral ossification and articular cartilage regeneration, and circular RNAs (circRNAs), which arise from various genes and regulate gene expression by adsorbing miRNAs, are known to be synthesized from CCN2 in human vascular endothelial cells and other types of cells. However, in chondrocytes, not only the function but also the presence of CCN2-derived circRNA remains completely unknown. In the present study, we investigated the expression and function of CCN2-derived circRNAs in chondrocytes. Amplicons smaller than those from known CCN2-derived circRNAs were observed using RT-PCR analysis that could specifically amplify CCN2-derived circRNAs in human chondrocytic HCS-2/8 cells. The nucleotide sequences of the PCR products indicated novel circRNAs in the HCS-2/8 cells that were different from known CCN2-derived circRNAs. Moreover, the expression of several Ccn2-derived circRNAs in murine chondroblastic ATDC5 cells was confirmed and observed to change alongside chondrocytic differentiation. Next, one of these circRNAs was knocked down in HCS-2/8 cells to investigate the function of the human CCN2-derived circRNA. As a result, CCN2-derived circRNA knockdown significantly reduced the expression of aggrecan mRNA and proteoglycan synthesis. Our data suggest that CCN2-derived circRNAs are expressed in chondrocytes and play a role in chondrogenic differentiation.

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DOI： 10.1007/s12079-023-00782-7

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その他リンク： https://link.springer.com/article/10.1007/s12079-023-00782-7/fulltext.html

A case of epidermoid cyst considered as originated from the abdominal skin tissue inserted into the temporomandibular joint 52 years ago

Soma Kato, Katsuhiko Amano, Norifumi Moritani, Yuki Nagata, Natsuki Segami, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2023年8月

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