研究者詳細 - 飯田　征二

論文 - 飯田　征二

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骨性癒着が疑われた上顎中切歯を有する上顎前突症例に対する外科的矯正治療 4前歯での上顎前歯部歯槽骨切り術

谷本裕子, 森谷徳文, 松村達志, 有村友紀, 近藤星, 飯田征二

中・四国矯正歯科学会雑誌 35 ( 1 ) 51 - 66 2023年8月

記述言語：日本語出版者・発行元：中・四国矯正歯科学会

今回,上顎4前歯部の歯槽骨切り術を施術した上顎前突症例について報告する.患者は初診時年齢15歳3ヵ月の男子で,上顎前歯の突出を主訴として来院した.12歳時に上顎右側中切歯の打撲の既往があった.側面観は凸型で,口唇の突出および頤筋の緊張感を認めた.∠SNAは81.9°,∠SNBは73.5°,∠ANBは8.4°で骨格性II級を呈していた.上顎前歯は著しく唇側傾斜し,オーバージェットは14.0mm,オーバーバイトは4.0mmで,大臼歯関係および犬歯関係は両側ともにアングルII級を呈していた.上顎右側第一小臼歯と下顎右側第二小臼歯は交叉咬合であった.上顎両側第一小臼歯の片顎抜去による治療方針とし治療を開始したが,動的治療開始10ヵ月後の犬歯牽引中に上顎右側中切歯の骨性癒着が疑われた.治療計画を矯正歯科治療単独から,犬歯牽引後に上顎4前歯を上顎前歯部歯槽骨切り術にて後方移動する方針に変更した.術前矯正治療を1年11ヵ月行った後に上顎前歯部歯槽骨切り術を施術した.術後矯正治療1年5ヵ月後に動的治療を終了し保定に移行した.∠SNAは80.8°,∠SNBは73.7°,∠ANBは7.1°になり,上顎前歯は標準的傾斜となり,オーバージェットは2.6mm,オーバーバイトは3.5mmに改善された.上顎4前歯部の歯槽骨切り術により上顎前歯部は後退し,凸型の側貌と口唇閉鎖不全は改善し良好な側貌が得られた.保定開始後2年3ヵ月経過時においても,良好な顔貌と咬合は維持されている.(著者抄録)

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副甲状腺ホルモン受容体シグナルはマウス鼻軟骨の形成に必須である

天野克比古, 北岡好大, 栗岡恭子, 田中晋, 飯田征二

日本口腔科学会雑誌 72 ( 2 ) 151 - 151 2023年7月

頭蓋顔面の発育を制御する頭蓋底軟骨におけるヘッジホッグシグナル受容性の違いと特徴

天野克比古, 加藤壮真, 飯田征二

日本顎変形症学会雑誌 33 ( 2 ) 223 - 223 2023年5月

下顎頭内側に周辺性骨腫を有する顔面非対称患者に外科的矯正治療を行った1例

河野加奈, 竹本史子, 太田明美, 森谷徳文, 加藤壮真, 飯田征二, 上岡寛

日本顎変形症学会雑誌 33 ( 2 ) 207 - 207 2023年5月

Quality of life after tongue cancer treatment and its influencing factors: A cross‐sectional study of Japanese patients

Hisako Sasahara, Yuko Kurawaki, Kenichiro Uchida, Tatsushi Matsumura, Hideo Shigeishi, Yasutaka Hayashido, Shigeaki Toratani, Seiji Iida, Katsuaki Mishima, Kouji Ohta, Masaru Sugiyama

Oral Science International 2023年4月

口腔支持療法により外来放射線治療を完遂できた口腔癌3症例

武田斉子, 有村友紀, 田村庄平, 中辻和樹, 三上彩可, 松崎秀信, 丸山貴之, 横井彩, 天野克比古, 水川展吉, 飯田征二

日本口腔ケア学会雑誌 17 ( 3 ) 242 - 242 2023年4月

Treatment of Severe Open Bite Malocclusion with Four-Piece Segmental Horseshoe Le Fort I Osteotomy.

Mitsuhiro Hoshijima, Naoki Oka, Tatsushi Matsumura, Seiji Iida, Hiroshi Kamioka

Acta medica Okayama 77 ( 1 ) 97 - 104 2023年2月

記述言語：英語

Appropriate operations in severe anterior open bite (AOB) cases are extremely complicated to perform because of the multiple surgical procedures involved, the difficulty of predicting posttreatment aesthetics, and the high relapse rate. We herein report a 16-year-old girl with skeletal Class II, severe AOB malocclusion, and crowding with short roots, and aesthetic and functional problems. Four-piece segmental Le Fort I osteotomy with horseshoe osteotomy was performed for maxillary intrusion, and bilateral sagittal split ramus osteotomy (SSRO) and genioplasty were performed for mandibular advancement. The malocclusion and skeletal deformity were significantly improved by the surgical orthodontic treatment. Functional and aesthetic occlusion with an improved facial profile was established, and no further root shortening was observed. Acceptable occlusion and dentition were maintained after a two-year retention period. This strategy of surgical orthodontic treatment with a complicated operative procedure might be effective for correcting certain severe AOB malocclusion cases.

DOI： 10.18926/AMO/64369

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Osteonecrosis of the Jaw in Two Rheumatoid Arthritis Patients Not Treated with a Bisphosphonate

Katsuhiko Amano, Akinari Sugauchi, Chiaki Yamada, Mikihiko Kogo, Seiji Iida

ACTA MEDICA OKAYAMA 77 ( 1 ) 111 - 116 2023年2月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：OKAYAMA UNIV MED SCHOOL

Medication-related osteonecrosis of the jaw (MRONJ) is a side effect in patients taking bone-modifying agents (BMAs), which are highly beneficial for treating osteoporosis and cancer. Bisphosphonates are prescribed to treat secondary osteoporosis in patients with rheumatoid arthritis (RA). We recently encountered two unusual cases of intraoral ONJ in RA patients who had not been treated with a BMA and did not have features of methotrexate-associated lymphoproliferative disorder. Their ONJ stage II bone exposures were treated by conservative therapy, providing good prognoses. These cases indicate that ONJ can occur in RA patients not treated with bisphosphonates. Several risk factors are discussed.

Web of Science

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上顎骨病変

古庄寿子, 佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 水川展吉, 飯田征二, 柿本直也, 宮内睦美

日本口腔診断学会雑誌 36 ( 1 ) 48 - 48 2023年2月

Mandibular condylar displacement and the associated factors following intraoral vertical ramus osteotomy

Yuki Nagata, Norifumi Moritani, Katsuhiko Amano, Yuki Arimura, Kazuki Nakatsuji, Soma Kato, Ayaka Mikami, Tatsushi Matsumura, Seiji Iida

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 35 ( 5 ) 390 - 396 2023年1月

QUAD shotによる緩和的放射線治療を適用した終末期口腔癌の1例

兵頭誠治, 加藤祐季, 加藤昌, 武田斉子, 水川展吉, 飯田征二

日本口腔外科学会雑誌 69 ( 1 ) 9 - 14 2023年1月

記述言語：日本語出版者・発行元：(公社)日本口腔外科学会

79歳男性。既往として40年前に右下顎歯肉癌に対し手術と放射線治療が行われていた。今回、右下顎部の疼痛ならびに開口障害を主訴に、近在の歯科医院より精査目的で当科へ紹介となった。画像所見、生検結果を踏まえて、右下顎歯肉癌の再発と診断され、患者の全身状態、希望よりQUAD shotによる緩和的放射線治療が行われた。その結果、QUAD shotとの併用放射線増感剤にPTXを選択し、1コース終了時より腫瘍は縮小し、疼痛の改善傾向がみられた。更に3コース終了後にはオピオイドを中止し、NSAIDsのみで日常生活を過ごせるようになり、摂食機能の改善で食事量の増加から体重減少や低栄養が改善された。最終的には患者はQOLを維持したまま最期を迎えることができた。

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01073&link_issn=&doc_id=20230201450002&doc_link_id=10.5794%2Fjjoms.69.9&url=https%3A%2F%2Fdoi.org%2F10.5794%2Fjjoms.69.9&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

上顎骨病変

古庄寿子, 佐藤亜希, 松村達志, 中野誠, 澤木康一, 吉岡洋祐, 明石翔, 水川展吉, 飯田征二, 柿本直也, 宮内睦美

日本口腔内科学会雑誌 28 ( 2 ) 72 - 72 2022年12月

口唇裂・口蓋裂児に関する臨床統計的検討(2019)

高木律男, 児玉泰光, 飯田征二, 井上直子, 小林眞司, 阪井丘芳, 須佐美隆史, 須田直人, 中村典史, 宮脇剛司, 古郷幹彦

日本口蓋裂学会雑誌 47 ( 3 ) 210 - 219 2022年10月

記述言語：日本語出版者・発行元：(一社)日本口蓋裂学会

一社・日本口蓋裂学会では,学術調査委員会の2020年度の事業として,2019年1年間の会員施設における新規患者について臨床的検討を行った。49施設より965例の登録があり,以下の結果を得た。1)症型別では辰裂110例(11.4%),唇顎裂206例(21.3%),唇顎口蓋裂388例(40.2%),口蓋裂193例(20.0%),粘膜下口蓋裂52例(5.4%),その他16例(1.7%)であった。2)罹患側では左側368例(52.2%),右側183例(26.0%),両側性160例(22.7%)。両側性は唇裂で少なく,唇顎口蓋裂で他の症型に比べて多かった。3)性別では女性432例(44.8%),男性533例(55.2%)。多くの症型で男性が多い中,口蓋裂では若干であるが,女性の方が多かった。4)出生時体重では,粘膜下口蓋裂で他の症型よりも低体重であった。5)出生前診断では,外表に変化のある口唇裂を含む症型で50%程度であった。6)両親の年齢では,全体に父親が母親よりも若干高年齢であったが症型間に差はなかった。7)血族内での出生では,いずれの症型も6～8%をしめていた。8)併発疾患および9)症候群,染色体異常については,口蓋裂および粘膜下口蓋裂児において頻度が高かった。併発疾患については,1例で複数の併発がみられる場合が多かった。なお,症型間で統計処理(カイ二乗検定)を行い,性差,罹患側,生下時体重,併発疾患,症候群・染色体異常において有意差(p<0.05)を認めた。以上,1年間に出生した日本人の口唇裂・口蓋裂児の多数例の検討から有意義なデータが得られた。(著者抄録)

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その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J01071&link_issn=&doc_id=20221208300004&doc_link_id=10.11224%2Fcleftpalate.47.210&url=https%3A%2F%2Fdoi.org%2F10.11224%2Fcleftpalate.47.210&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

Attempt of thyX gene silencing and construction of a thyX deleted clone in a Mycobacterium bovis BCG

Yuki Arimura, Yusuke Minato, Takayuki Wada, Masaaki Nakayama, Ayako Ryumon, Nao Hirata, Chie Nakajima, Yasuhiko Suzuki, Manabu Ato, Kazuo Kobayashi, Naoko Ohara, Seiji Iida, Naoya Ohara

Microbiology and Immunology 66 ( 1 ) 10 - 14 2022年1月

Comparing the Osteogenic Potential and Bone Regeneration Capacities of Dedifferentiated Fat Cells and Adipose-Derived Stem Cells In Vitro and In Vivo: Application of DFAT Cells Isolated by a Mesh Method. 国際誌

Kiyofumi Takabatake, Masakazu Matsubara, Eiki Yamachika, Yuki Fujita, Yuki Arimura, Kazuki Nakatsuji, Keisuke Nakano, Histoshi Nagatsuka, Seiji Iida

International journal of molecular sciences 22 ( 22 ) 2021年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: We investigated and compared the osteogenic potential and bone regeneration capacities of dedifferentiated fat cells (DFAT cells) and adipose-derived stem cells (ASCs). METHOD: We isolated DFAT cells and ASCs from GFP mice. DFAT cells were established by a new culture method using a mesh culture instead of a ceiling culture. The isolated DFAT cells and ASCs were incubated in osteogenic medium, then alizarin red staining, alkaline phosphatase (ALP) assays, and RT-PCR (for RUNX2, osteopontin, DLX5, osterix, and osteocalcin) were performed to evaluate the osteoblastic differentiation ability of both cell types in vitro. In vivo, the DFAT cells and ASCs were incubated in osteogenic medium for four weeks and seeded on collagen composite scaffolds, then implanted subcutaneously into the backs of mice. We then performed hematoxylin and eosin staining and immunostaining for GFP and osteocalcin. RESULTS: The alizarin red-stained areas in DFAT cells showed weak calcification ability at two weeks, but high calcification ability at three weeks, similar to ASCs. The ALP levels of ASCs increased earlier than in DFAT cells and showed a significant difference (p < 0.05) at 6 and 9 days. The ALP levels of DFATs were higher than those of ASCs after 12 days. The expression levels of osteoblast marker genes (osterix and osteocalcin) of DFAT cells and ASCs were higher after osteogenic differentiation culture. CONCLUSION: DFAT cells are easily isolated from a small amount of adipose tissue and are readily expanded with high purity; thus, DFAT cells are applicable to many tissue-engineering strategies and cell-based therapies.

DOI： 10.3390/ijms222212392

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Camouflage Treatment for Skeletal Maxillary Protrusion and Lateral Deviation with Classic-Type Ehlers-Danlos Syndrome.

Mitsuhiro Hoshijima, Noriaki Kawanabe, Seiji Iida, Takashi Yamashiro, Hiroshi Kamioka

Acta medica Okayama 75 ( 2 ) 205 - 212 2021年4月

記述言語：英語

We herein report the case of a 19-year-old female with a transverse discrepancy, skeletal Class II malocclusion, severe crowding with concerns of classic-type Ehlers-Danlos syndrome (EDS), aesthetics problems and functional problems. The main characteristics of classic EDS are loose-jointedness and fragile, easily bruised skin that heals with peculiar "cigarette-paper" scars. The anteroposterior and transverse skeletal discrepancies can generally be resolved by maxilla repositioning and mandibular advancement surgery following pre-surgical orthodontic treatment. However, this patient was treated with orthodontic camouflage but not orthognathic surgery because of the risks of skin bruising, poor healing and a temporomandibular disorder. A satisfactory dental appearance and occlusion were achieved after camouflage treatment with orthodontic anchor screws and the use of Class II elastics, including the preservation of the stomatognathic functions. Acceptable occlusion and dentition were maintained after a two-year retention period. This treatment strategy of orthodontic camouflage using temporary anchorage, such as anchor screws and Class II elastics, may be a viable treatment option for skeletal malocclusion patients with EDS.

DOI： 10.18926/AMO/61902

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Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis. 国際誌

Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota

Journal of oral biosciences 62 ( 3 ) 280 - 288 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Anti-osteoclastic treatments for breast cancer occasionally cause medication-related osteonecrosis of the jaw. Moreover, elevated glycolytic activity, which is known as the Warburg effect, is usually observed in these breast cancer cells. Previously, we found that cellular communication network factor 2 (CCN2) production and glycolysis enhanced each other in chondrocytes. Here, we evaluated the interplay between CCN2 and glycolysis in breast cancer cells, as we suspected a possible involvement of CCN2 in the Warburg effect in highly invasive breast cancer cells. METHODS: Two human breast cancer cell lines with a distinct phenotype were used. Glycolysis was inhibited by using 2 distinct compounds, and gene silencing was performed using siRNA. Glycolysis and the expression of relevant genes were monitored via colorimetric assays and quantitative RT-PCR, respectively. RESULTS: Although CCN2 expression was almost completely silenced when treating invasive breast cancer cells with a siRNA cocktail against CCN2, glycolytic activity was not affected. Notably, the expression of glycolytic enzyme genes, which was repressed by CCN2 deficiency in chondrocytes, tended to increase upon CCN2 silencing in breast cancer cells. Inhibition of glycolysis, which resulted in the repression of CCN2 expression in chondrocytic cells, did not alter or strongly enhanced CCN2 expression in the invasive and non-invasive breast cancer cells, respectively. CONCLUSIONS: High CCN2 expression levels play a critical role in the invasion and metastasis of breast cancer. Thus, a collapse in the intrinsic repressive machinery of CCN2 due to glycolysis may induce the acquisition of an invasive phenotype in breast cancer cells.

DOI： 10.1016/j.job.2020.07.001

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片側性唇顎口蓋裂を伴ったt(11;22)(q23.3;q11.2)均衡型相互転座の1例

有村友紀, 山田智明, 岡田亜由美, 薬師寺翔太, 岡本成美, 飯田征二

日本口腔外科学会雑誌 66 ( 8 ) 406 - 410 2020年8月

記述言語：日本語出版者・発行元：(公社)日本口腔外科学会

症例は3ヵ月男児で、左側唇口蓋裂を認め、出生後早期の染色体G-banding検査にて46,XY,t(11;22)(q23.3;q11.2)と診断された。口蓋裂一貫治療目的に当科を紹介受診した。初診時にホッツ床作製のための印象採得を行い、生後3ヵ月からホッツ床による顎誘導ならびに哺乳の改善を行った。生後5ヵ月目に全身麻酔下にて口唇形成術を施行し、口蓋裂に対しては2段階による口蓋形成術を行うものとし、初回は1歳3ヵ月時に軟口蓋形成術(Furlow法)を行い、1歳11ヵ月で2回目となる硬口蓋閉鎖術を施行した。術後経過は良好であり、2歳2ヵ月から言語聴覚士による発達検査、言語治療を開始した。鼻咽腔閉鎖機能不全や構音障害はみられず、定期的な経過観察を行っている。現在5歳8ヵ月で反対咬合を認めている。

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J01073&link_issn=&doc_id=20200828330010&doc_link_id=130007928053&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007928053&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Epidemiological Correlations Between Head and Neck Cancer and Hepatitis B Core Antibody Positivity. 国際誌

Mai Fukushima Komori, Takuji Kimura, Shin Kariya, Tomoo Onoda, Seiko Takeda, Nobuyoshi Mizukawa, Seiji Iida, Yoshihiro Kimata, Kazunori Nishizaki

Anticancer research 40 ( 4 ) 2393 - 2403 2020年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND/AIM: Hepatitis B core (HBc) antibody positivity indicates a history of hepatitis B virus (HBV) infection and latent infection. PATIENTS AND METHODS: We conducted a retrospective case-control study of 512 and 495 head and neck cancer (HNC) and non-HNC patients treated at the Okayama University Hospital, Head and Neck Cancer Center from 2008-2017. Demographic data and risk factors that might affect HNC diagnosis were analyzed to assess their effects. RESULTS: Cancer diagnosis was found to correlate with HBc antibody positivity [odds ratio (OR)=1.50, 95% confidence interval (CI)=1.09-2.08], smoking (OR=3.03, 95%CI=2.16-4.25), and a previous history of cancer (OR=4.12, 95%CI=2.79-6.09). The HBs antigen positivity rate in both groups was very close to that observed in the general Japanese population. The HBc antibody positivity rate was very high only in the HNC group. CONCLUSION: HBc antibody positivity and HNC are epidemiologically correlated.

DOI： 10.21873/anticanres.14209

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The Elimination of Dental Crowding and Development of a Proper Dental Arch by Maxillary Anterior Segmental Distraction Osteogenesis for a Patient With UCLP. 査読国際誌

Chihiro Tanikawa, Donghoon Lee, Yuri Yamamoto Oonishi, Seiji Haraguchi, Tomonao Aikawa, Mikihiko Kogo, Seiji Iida, Takashi Yamashiro

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 56 ( 7 ) 978 - 985 2019年8月

記述言語：英語

OBJECTIVE: This report describes the case of a male patient with a complete unilateral cleft lip and palate who presented with midface deficiency and an anteroposteriorly constricted maxilla. DESIGN: Case report Interventions: Correction involved anterior distraction of the segmented maxilla. RESULTS: The present case demonstrates that elongation of the maxilla with anterior distraction is an effective way to develop a proper dental arch, correct anterior and posterior crowding, and improve a midface deficiency.

DOI： 10.1177/1055665618821831

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