Faculty Profiles - OTSUKA Fumio

Papers - OTSUKA Fumio

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多発骨折を契機に発見され、社会的介入を要したビタミンD欠乏の1例

須山敦仁, 大塚勇輝, 中野靖浩, 松田祐依, 櫻田泰江, 小比賀美香子, 豊川達也, 大塚文男

日本内分泌学会雑誌 99 ( 1 ) 389 - 389 2023.5

後縦靱帯骨化症を合併し椎弓切除術を要した成人XLHの1例

山本紘一郎, 本多寛之, 大國皓平, 中野靖浩, 徳増一樹, 長谷川功, 長谷川高誠, 安原隆雄, 大塚文男

日本内分泌学会雑誌 99 ( 1 ) 330 - 330 2023.5

新型コロナウイルス後遺症診療において発見された内分泌代謝疾患

中野靖浩, 副島佳晃, 田中秀一, 大塚勇輝, 徳増一樹, 本多寛之, 長谷川功, 萩谷英大, 大塚文男

日本内分泌学会雑誌 99 ( 1 ) 323 - 323 2023.5

Case Series of Granulicatella Bacteremia: A Single-centered, Five-year Retrospective Study. Reviewed

Shinnosuke Fukushima, Hideharu Hagiya, Koji Iio, Hiroyuki Honda, Tomoharu Ishida, Hirokazu Nagaoka, Kou Hasegawa, Fumio Otsuka

Acta medica Okayama 77 ( 2 ) 203 - 207 2023.4

Authorship：Last author Language：English

Granulicatella species are rare, nutritionally variant streptococci that cause infective endocarditis. Their clinical and microbiological characteristics remain unknown. We reviewed five years of Granulicatella cases in our hospital database (Jan 2017-Jun 2022), finding 6 Granulicatella adiacens cases and 1 Granulicatella elegans case. Clinical backgrounds and bacteremia sources were diverse; 3 cases developed polymicrobial bacteremia. Antimicrobial testing showed non-susceptibility to penicillin G in 4 of 7 cases (57.1%), and high susceptibility to carbapenems and vancomycin in all cases. Determining optimal antibiotic therapy for Granulicatella infections is vital in this era of antimicrobial resistance.

DOI： 10.18926/AMO/65151

PubMed

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四肢と左臀部に生じたextensive subcutaneous sarcoidosisの1例

臼井真菜, 杉原悟, 立花宏太, 安富陽平, 川上佳夫, 中本健太, 大塚文男, 森実真

西日本皮膚科 85 ( 2 ) 109 - 112 2023.4

Language：Japanese Publisher：日本皮膚科学会-西部支部

71歳,女性。1年前に右膝と両側前腕に皮下硬結を自覚し,その後左臀部にも皮下硬結が出現した。右膝に20×10cm,左臀部に10×7cm,右前腕に10×7cm,左前腕に2個の7×5cmの板状皮下硬結がみられた。皮膚生検では皮下脂肪組織に非乾酪壊死性類上皮細胞肉芽腫を認め,sIL-2Rは1697.0U/mlと高値であった。胸部CTでは縦隔リンパ節の軽度腫大があり,Gaシンチグラフィーでは四肢と左臀部の皮下硬結部に高度な集積を認め,extensive subcutaneous sarcoidosisと診断した。膝関節屈曲制限が生じる懸念があったためプレドニゾロン25mg/day内服を開始したところ,皮下病変は速やかに縮小し,sIL-2Rは418.3U/mlまで低下した。皮下型サルコイドーシスではトラニラストやミノサイクリン内服で軽快する症例や,無治療で軽快する症例もあるが,本症例では,右膝部皮下病変の拡大による歩行障害が懸念されたため,ステロイド内服による治療を選択した。広範な皮下型病変を呈するサルコイドーシスでは,sIL-2Rや皮膚病変のサイズなどを総合的に評価し,病勢を検討することが必要である。(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J01003&link_issn=&doc_id=20230516250006&doc_link_id=10.2336%2Fnishinihonhifu.85.109&url=https%3A%2F%2Fdoi.org%2F10.2336%2Fnishinihonhifu.85.109&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Symptomatic Characteristics of Hypozincemia Detected in Long COVID Patients. Reviewed International journal

Yui Matsuda, Kazuki Tokumasu, Yuki Otsuka, Naruhiko Sunada, Hiroyuki Honda, Yasue Sakurada, Yasuhiro Nakano, Toru Hasegawa, Mikako Obika, Keigo Ueda, Fumio Otsuka

Journal of clinical medicine 12 ( 5 ) 2023.3

Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: The aim of this study was to determine the characteristics of hypozincemia in long COVID patients. METHODS: This study was a single-center retrospective observational study for outpatients who visited the long COVID clinic established in a university hospital during the period from 15 February 2021 to 28 February 2022. Characteristics of patients with a serum zinc concentration lower than 70 μg/dL (10.7 μmol/L) were compared with characteristics of patients with normozincemia. RESULTS: In a total of 194 patients with long COVID after excluding 32 patients, hypozincemia was detected in 43 patients (22.2%) including 16 male patients (37.2%) and 27 female patients (62.8%). Among various parameters including the background characteristics of the patients and medical histories, the patients with hypozincemia were significantly older than the patients with normozincemia (median age: 50 vs. 39 years). A significant negative correlation was found between serum zinc concentrations and age in male patients (R = -0.39; p < 0.01) but not in female patients. In addition, there was no significant correlation between serum zinc levels and inflammatory markers. General fatigue was the most frequent symptom in both male patients with hypozincemia (9 out of 16: 56.3%) and female patients with hypozincemia (8 out of 27: 29.6%). Patients with severe hypozincemia (serum zinc level lower than 60 μg/dL) had major complaints of dysosmia and dysgeusia, which were more frequent complaints than general fatigue. CONCLUSIONS: The most frequent symptom in long COVID patients with hypozincemia was general fatigue. Serum zinc levels should be measured in long COVID patients with general fatigue, particularly in male patients.

DOI： 10.3390/jcm12052062

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ペースメーカ留置を回避出来た粘液水腫性昏睡による洞不全症候群の1例

長谷川功, 原田洸, 山本紘一郎, 中野靖浩, 大塚文男

日本内分泌学会雑誌 98 ( 5 ) 1302 - 1302 2023.3

若年男性の橋本病による粘液水腫の1例

山本紘一郎, 本多寛之, 中野靖浩, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 5 ) 1303 - 1303 2023.3

ハンセン病に対する免疫抑制療法を背景に発症した播種性糞線虫症の1例

中本健太, 萩谷英大, 平佑貴, 庵谷紘美, 中野靖浩, 長谷川功, 大塚文男

感染症学雑誌 97 ( 2 ) 52 - 57 2023.3

Language：Japanese Publisher：(一社)日本感染症学会

症例は30歳代ネパール人男性で、下痢と嘔気を主訴とした。ハンセン病(LL型)と新型コロナウイルス感染症の既往があり、らい反応に対して長期間のステロイド製剤内服による免疫抑制療法を行っていた。各種検査所見より、糞線虫の過剰感染状態による播種性糞線虫症と診断した。栄養状態は不良で、寄生虫の消化管内過剰増殖に伴う腸管浮腫を認め、イベルメクチンは吸収不良で血中濃度が不十分であった。多臓器不全を併発したため集学的治療を行ったが第36病日に死亡した。日本では糞線虫症は稀であるが、インバウンドの増加に伴い播種性糞線虫症のリスクが増加する可能性があり、ステロイドの長期内服などで免疫抑制状態の可能性がある場合は寄生虫スクリーニングを行う必要があると考えられた。

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【臨床検査で患者を救え!-知っておいてほしい疾患】重度で長期の甲状腺機能低下症

越智可奈子, 中野靖浩, 原田洸, 長谷川功, 大塚文男

臨床検査 67 ( 3 ) 246 - 253 2023.3

プラスミノーゲン欠乏症に腸管型ベーチェット病を合併し広範な皮膚粘膜病変を発症した一例

中土井崇人, 勝山恵理, 寺嶋悠也, 松本和也, 廣瀬啓, 志田原健太, 縄稚翔一, 浅野洋介, 片山祐, 宮脇義亜, 勝山隆行, 楢崎真理子, 松本佳則, 佐田憲映, 大塚文男, 和田淳

日本リウマチ学会総会・学術集会プログラム・抄録集 67回 795 - 795 2023.3

ハンセン病に対する免疫抑制療法を背景に発症した播種性糞線虫症の1例

中本健太, 萩谷英大, 平佑貴, 庵谷紘美, 中野靖浩, 長谷川功, 大塚文男

感染症学雑誌 97 ( 2 ) 52 - 57 2023.3

Language：Japanese Publisher：(一社)日本感染症学会

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ビジュアルで見るプライマリ・ケア毒針毛による皮膚炎

大塚勇輝, 長岡寛和, 花山宜久, 大塚文男, 金森達也

日本プライマリ・ケア連合学会誌 46 ( 1 ) 33 - 34 2023.3

若年男性の橋本病による粘液水腫の1例

山本紘一郎, 本多寛之, 中野靖浩, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 5 ) 1303 - 1303 2023.3

Buruli ulcer caused by Mycobacterium ulcerans subsp. shinshuense: A case report. Reviewed International journal

Takumi Fujimori, Hideharu Hagiya, Koji Iio, Osamu Yamasaki, Yuji Miyamoto, Yoshihiko Hoshino, Ayaka Kakehi, Mami Okura, Hiroshi Minabe, Yukika Yokoyama, Fumio Otsuka, Akihito Higashikage

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 29 ( 5 ) 523 - 526 2023.2

Language：English

Buruli ulcer is the third most common mycobacterial infection worldwide and is mainly diagnosed in tropical regions. Globally, this progressive disease is caused by Mycobacterium ulcerans; however, Mycobacterium ulcerans subsp. shinshuense, an Asian variant, has been exclusively identified in Japan. Because of insufficient clinical cases, the clinical features of M. ulcerans subsp. shinshuense-associated Buruli ulcer remain unclear. A 70-year-old Japanese woman presented with erythema on her left backhand. The skin lesion deteriorated without an apparent etiology of inflammation, and she was referred to our hospital 3 months after disease onset. A biopsy specimen was incubated in 2% Ogawa medium at 30 °C. After 66 days, we detected small yellow-pigmented colonies, suggesting scotochromogens. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI Biotyper; Bruker Daltonics, Billerica, MA, USA) indicated that the organism was Mycobacterium pseudoshottsii or Mycobacterium marinum. However, additional PCR testing for the insertion sequence 2404 (IS2404) was positive, suggesting that the pathogen was either M. ulcerans or M. ulcerans subsp. shinshuense. Further examination by 16S rRNA sequencing analysis, focusing on nucleotide positions 492, 1247, 1288, and 1449-1451, we finally identified the organism as M. ulcerans subsp. shinshuense. The patient was successfully treated with 12 weeks of clarithromycin and levofloxacin treatment. Mass spectrometry is the latest microbial diagnostic method; however, it cannot be used to identify M. ulcerans subsp. shinshuense. To accurately detect this enigmatic pathogen and uncover its epidemiology and clinical characteristics in Japan, more accumulation of clinical cases with accurate identification of the causative pathogen is essential.

DOI： 10.1016/j.jiac.2023.02.009

PubMed

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Trends in the Incidence of Japanese Spotted Fever in Japan: A Nationwide, Two-Decade Observational Study from 2001-2020. Reviewed International journal

Yuki Otsuka, Hideharu Hagiya, Shinnosuke Fukushima, Ko Harada, Toshihiro Koyama, Fumio Otsuka

The American journal of tropical medicine and hygiene 2023.2

Authorship：Last author Language：English Publishing type：Research paper (scientific journal)

The worldwide spread of tick-borne diseases (TBDs) has become a public health concern. Therefore, this study aimed to clarify trends in the incidence of Japanese spotted fever (JSF), one of Japan's most prevalent TBDs. Weekly infectious disease reports were used to calculate the annual incidence rates (AIRs) of JSF. Data were stratified by age and sex, and joinpoint regression analysis was performed to estimate the annual percentage change (APC). AIR and APC were geographically compared among the 47 prefectures. A total of 3,453 JSF cases were observed from 2001 to 2020. The AIR per 100,000 population was 0.03 in 2001, which increased approximately 10-fold to 0.33 in 2020. The average APC (AAPC) during the study period was 12.3% (95% CI: 10.7-13.9). By age group, the incidence of JSF increased more rapidly among the older population: 11.5% (95% CI: 10.1-12.9) in those aged ≥ 65 years and 8.9% (95% CI: 6.4-11.5) in those aged < 50 years. Although the AIR over the past two decades was higher in climatically warm regions located in southwestern Japan and on the Pacific coast, increases in the AAPC were notable in colder regions located in eastern Japan. The incidence of JSF continues to increase in Japan, especially among older populations and in eastern prefectures, where the disease has not been previously diagnosed.

DOI： 10.4269/ajtmh.22-0487

PubMed

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Mediastinal Abscess Induced by Group B Streptococcus Reviewed

Kenta Nakamoto, Hideharu Hagiya, Ruiko Hayashi, Fumio Otsuka

Internal Medicine 62 ( 3 ) 491 - 492 2023.2

コロナ禍にCaSR作動薬で長期管理し得た原発性副甲状腺機能亢進症の一例

大上莉央, 大塚勇輝, 中野靖浩, 高瀬了輔, 山下茉奈美, 山本紘一郎, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 4 ) 1079 - 1079 2023.2

成人期にPHEX新規変異によるX染色体連鎖性低リン血症性骨軟化症と診断した1例

山本紘一郎, 本多寛之, 高瀬了輔, 中野靖浩, 徳増一樹, 長谷川功, 長谷川高誠, 大塚文男

日本内分泌学会雑誌 98 ( 4 ) 1080 - 1080 2023.2

臨床検査室におけるナノポアシーケンシング技術を用いた新型コロナウイルス感染症の疫学的解析実用化に向けての取り組み

飯尾耕治, 後藤和義, 萩谷英大, 小川寛人, 三好諒, 大塚文男, 東影明人

医学検査 72 ( 2 ) 248 - 255 2023.2

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