Faculty Profiles - OTSUKA Fumio

Papers - OTSUKA Fumio

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Octreotide effect on cluster headache in acromegaly patients

Fumio Otsuka, Satoshi Mizobuchi, Hirofumi Makino

EUROPEAN JOURNAL OF ENDOCRINOLOGY 152 2005

Abrupt Enlargement of Adrenal Incidentaloma: A Case of Isolated Adrenal Metastasis

Tomoko MIYOSHI, Fumio OTSUKA, Jiro SUZUKI, Kenichi INAGAKI, Yoshihiro KANO, Toshio OGURA, Katsuyuki KIURA, Takashi SAIKA, Hirofumi MAKINO

Endocrine Journal 52 ( 6 ) 785 - 788 2005

Periodic Secretion of Adrenocorticotropin in a Patient with Cushing's Disease Manifested during Pregnancy

Tomoko MIYOSHI, Fumio OTSUKA, Jiro SUZUKI, Kenichi INAGAKI, Masaya TAKEDA, Yoshihiro KANO, Tetsuji YAMASHITA, Toshio OGURA, Isao DATE, Yasushi TANAKA, Kozo HASHIMOTO, Hirofumi MAKINO

Endocrine Journal 52 ( 3 ) 287 - 292 2005

Effect of cabergoline treatment on Cushing’s disease caused by aberrant adrenocorticotropin-secreting macroadenoma

T. Miyoshi, F. Otsuka, M. Takeda, K. Inagaki, J. Suzuki, T. Ogura, I. Date, K. Hashimoto, H. Makino

Journal of Endocrinological Investigation 27 ( 11 ) 1055 - 1059 2004.12

Characterization of the Bone Morphogenetic Protein (BMP) System in Human Pulmonary Arterial Smooth Muscle Cells Isolated from a Sporadic Case of Primary Pulmonary Hypertension: Roles of BMP Type IB Receptor (Activin Receptor-Like Kinase-6) in the Mitotic Action

Masaya Takeda, Fumio Otsuka, Kazufumi Nakamura, Kenichi Inagaki, Jiro Suzuki, Daiji Miura, Hideki Fujio, Hiromi Matsubara, Hiroshi Date, Tohru Ohe, Hirofumi Makino

Endocrinology 145 ( 9 ) 4344 - 4354 2004.9

Aldosterone regulation for 18 years in a case of primary aldosteronism

Tomoko Miyoshi , Fumio Otsuka, Toshio Ogura, Jiro Suzuki, Kenichi Inagaki, Masaya Takeda, Masayuki Kishida, Yukari Mimura, Atsushi Nagai, Hirofumi Makino

American Journal of Hypertension 17 ( 6 ) 546 - 548 2004.6

Cholestatic jaundice: An unusual symptom of isolated adrenocorticotropin deficiency in adults

F. Otsuka, K. Yamamoto, N. Shimada, J. Kageyama, T. Ogura, H. Makino

Journal of Endocrinological Investigation 27 ( 4 ) 404 - 405 2004.4

Ovarian bone morphogenetic proteins in female reproduction

ShunichiShimasakiR.KellyMooreGregory, F.EricksonFumioOtsuka

International Congress Series 1266 241 - 247 2004.4

Recent trends of hyperuricemia and obesity in Japanese male adolescents, 1991 through 2002

Toshio Ogura, Kazuharu Matsuura, Yosuke Matsumoto, Yukari Mimura, Masayuki Kishida, Fumio Otsuka, Kazuo Tobe

Metabolism 53 ( 4 ) 448 - 453 2004.4

Novel Action of Activin and Bone Morphogenetic Protein in Regulating Aldosterone Production by Human Adrenocortical Cells

Jiro Suzuki, Fumio Otsuka, Kenichi Inagaki, Masaya Takeda, Toshio Ogura, Hirofumi Makino

Endocrinology 145 ( 2 ) 639 - 649 2004.2

Publishing type：Research paper (scientific journal) Publisher：The Endocrine Society

Abstract

We have uncovered a functional bone morphogenetic protein (BMP) and activin system complete with ligands (BMP-6 and activin βA/βB), receptors (activin receptor-like kinase receptors 2, 3, and 4; activin type-II receptor; and BMP type-II receptor), and the binding protein follistatin in the human adrenocortical cell line H295R. Administration of activin and BMP-6 to cultures of H295R cells caused concentration-responsive increases in aldosterone production. The mRNA levels of steroidogenic acute regulatory protein or P450 steroid side-chain cleavage enzyme, the rate-limiting steps of adrenocortical steroidogenesis, were enhanced by activin and BMP-6. Activin and BMP-6 also activated the transcription of steroidogenic acute regulatory protein as well as the late-step steriodogenic enzyme CYP11B2. Activin enhanced ACTH-, forskolin-, or dibutyryl-cAMP- but not angiotensin II (Ang II)-induced aldosterone production, whereas BMP-6 specifically augmented Ang II-induced aldosterone production. Activin and ACTH but not BMP-6 increased cAMP production. Follistatin, which inhibits activin actions by binding, suppressed basal and ACTH-induced aldosterone secretion but failed to affect the Ang II-induced aldosterone level. Furthermore, MAPK signaling appeared to be involved in aldosterone production induced by Ang II and BMP-6 because an inhibitor of MAPK activation, U0126, reduced the level of aldosterone synthesis stimulated by Ang II and BMP-6 but not activin. In addition, Ang II reduced the expression levels of BMP-6 but increased that of activin βB, whereas ACTH had no effect on these levels. Collectively, the present data suggest that activin acts to regulate adrenal aldosterone synthesis predominantly by modulating the ACTH-cAMP-protein kinase A signaling cascade, whereas BMP-6 works primarily by modulating the Ang II-MAPK cascade in human adrenal cortex in an autocrine/paracrine fashion.

DOI： 10.1210/en.2003-0968

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The bone morphogenetic protein system in mammalian reproduction

S Shimasaki, RK Moore, F Otsuka, GF Erickson

ENDOCRINE REVIEWS 25 ( 1 ) 72 - 101 2004.2

Language：English Publisher：ENDOCRINE SOC

Using molecular, cellular, and genetic approaches, recent studies examining the role of the bone morphogenetic protein (BMP) family of growth factors in the reproductive system have led to significant breakthroughs in our understanding of mammalian reproduction and fertility. Gene expression studies have revealed that key components of the BMP system (ligands, receptors, signaling molecules, and binding proteins) exhibit coordinated spatial and temporal expression patterns in fundamental cell types throughout the reproductive system. Availability of recombinant BMPs has enabled functional studies that have demonstrated important biological activities of BMPs in controlling cellular proliferation, differentiation, and apoptosis in reproductive tissues. The physiological importance of the BMP system for mammalian reproduction has been further highlighted by the elucidation of the aberrant reproductive phenotypes of animals with naturally occurring mutations or targeted deletions of certain BMP family genes. Collectively, these studies have established the concept that the BMP system plays a crucial role in fertility in female and male mammals. The purpose of this article is to review the evidence underpinning the importance of the BMP system in mammalian reproduction.

DOI： 10.1210/er.2003-0007

Web of Science

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An Aberrant ACTH-producing Ectopic Pituitary Adenoma in the Sphenoid Sinus

Jiro SUZUKI, Fumio OTSUKA, Toshio OGURA, Masayuki KISHIDA, Masaya TAKEDA, Takashi TAMIYA, Tatsuya NISHIOKA, Yasushi TANAKA, Kozo HASHIMOTO, Hirofumi MAKINO

Endocrine Journal 51 ( 1 ) 97 - 103 2004