Faculty Profiles - OTSUKA Fumio

Papers - OTSUKA Fumio

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A Lethal Complication, Acute Necrotizing Pancreatitis, of Turner's Syndrome with Primary Hyperparathyroidism

Masayuki Kishida, Fumio Otsuka, Yukari Mimura, Toshio Ogura, Hirofumi Makino

Endocrine Journal 50 ( 6 ) 835 - 836 2003

The role of bone morphogenetic proteins in ovarian function

S Shimasaki, RK Moore, GF Erickson, F Otsuka

REPRODUCTION 61,323-337 323 - 337 2003

Language：English Publishing type：Research paper (scientific journal) Publisher：BIOSCIENTIFICA LTD

Bone morphogenetic proteins (BMPs) represent the largest subclass of growth factors in the transforming growth factor beta (TGF-beta) superfamily. BMPs have proven to be multifunctional regulators of a wide variety of biological processes in numerous types of cell and tissue. The role of inhibins, activins and TGF-betas (which also belong to the TGF-beta superfamily) in reproduction has been studied extensively over the last 15 years. However, there were no reports on the role of BMPs in the mammalian ovary until 1999 when we reported an intrinsic ovarian BMP system replete with BMP ligands, receptors and novel biological functions. Since this report it has become clear that the BMP system plays an important role in the regulation of ovarian function, evidenced by the ability of BMPs to control granulosa cell proliferation and cytodifferentiation, as well as oocyte development. The physiological relevance of the BMP system has recently been highlighted by the discovery that genetic mutations in the BMP-15 ligand or the BMPtype IB receptor lead to critical aberrations in folliculogenesis and ovulation. This review provides a current overview of the rapidly emerging field of the BMP system in mammalian ovarian function.

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Relationship between Adrenomedullin and Vasopressin-Aquaporin System under General Anesthesia

Toshio Ogura, Kiyoshi Morita, Mamoru Takeuchi, Fumio Otsuka, Tatsuo Iwasaki, Katsunori Oe, Kazuharu Matsuura, Kazuo Tobe, Yukari Mimura, Masayuki Kishida, Hirofumi Makino, Masahisa Hirakawa

Hormone Research in Paediatrics 59 ( 1 ) 30 - 34 2003

Publishing type：Research paper (scientific journal) Publisher：S. Karger AG

Aim: The roles of adrenomedullin (AM) in body fluid balance under general anesthesia were investigated. Methods: Time course changes in plasma osmolality, AM, arginine vasopressin (AVP), and urinary aquaporin 2 (AQP2) in 17 patients undergoing abdominal surgery under general anesthesia were examined. Results: Increases in plasma AM levels were observed in parallel with increases in the levels of urinary AQP2/creatinine (Cr) before induction and 90 and 180 min after initiation of anesthesia. Significant correlations between plasma AM and urinary AQP2/Cr (r = 0.62, p < 0.0001) as well as urinary AVP/Cr and AQP2/Cr (r = 0.60, p < 0.0001) were uncovered. Multivariate stepwise analysis identified plasma AM as the critical independent factor affecting urinary AQP2/Cr level. Conclusion: A novel correlation of AM and AQP2 which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia.

DOI： 10.1159/000067933

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Role of Bradykinin in Renoprotective Effects by Angiotensin II Type 1 Receptor Antagonist in Salt-Sensitive Hypertension.

Kazuaki YOKOTA, Masayuki KISHIDA, Toshio OGURA, Jiro SUZUKI, Fumio OTSUKA, Yukari MIMURA, Masaya TAKEDA, Yoshio NAKAMURA, Hirofumi MAKINO

Hypertension Research 26 ( 3 ) 265 - 272 2003

A Novel Function of Bone Morphogenetic Protein-15 in the Pituitary: Selective Synthesis and Secretion of FSH by Gonadotropes

Fumio Otsuka, Shunichi Shimasaki

Endocrinology 143 ( 12 ) 4938 - 4941 2002.12

A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis

Fumio Otsuka, Shunichi Shimasaki

Proceedings of the National Academy of Sciences 99 ( 12 ) 8060 - 8065 2002.6

Publishing type：Research paper (scientific journal) Publisher：Proceedings of the National Academy of Sciences

Although the existence of a regulatory paracrine feedback system between oocytes and follicular somatic cells has been postulated for some time, there has not yet been any definitive evidence that such a communication system exists. Herein we present a previously undescribed oocyte-granulosa cell (GC) feedback communication system involving an oocyte-derived factor, bone morphogenetic protein-15 (BMP-15) and a GC-derived factor, kit ligand (KL), both of which have been shown to be crucial regulators of female reproduction. We used a coculture system of rat oocytes and GCs and found that BMP-15 stimulates KL expression in GCs, whereas KL inhibits BMP-15 expression in oocytes, thus forming a negative feedback loop. Moreover, KL, like BMP-15, exhibited mitotic activity on GCs in the presence of oocytes. Because c-kit (KL receptor) is expressed in oocytes but not GCs, the oocytes must be involved in mediating the KL-induced GC mitosis. Furthermore, the blockage of c-kit signaling in oocytes by using a c-kit neutralizing antibody markedly suppressed BMP-15-induced GC mitosis, suggesting that the oocyte must play a role in the GC responses to BMP-15. In contrast, the c-kit antibody had no effect on the mitotic activities of two other known GC mitogens, activin-A and BMP-7. Altogether, this study presents direct evidence of a negative feedback system governed by oocyte-derived BMP-15 and GC-derived KL, and demonstrates that the mitotic activities of BMP-15 and KL for GCs depend on this oocyte–GC communication system. We hypothesize that the negative feedback system most likely plays a pivotal role in early folliculogenesis.

DOI： 10.1073/pnas.122066899

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Role of ERK1/2 in the Differential Synthesis of Progesterone and Estradiol by Granulosa Cells

R.Kelly Moore, Fumio Otsuka, Shunichi Shimasaki

Biochemical and Biophysical Research Communications 289 ( 4 ) 796 - 800 2001.12

Follistatin Inhibits the Function of the Oocyte-Derived Factor BMP-15

Fumio Otsuka, R.Kelly Moore, Shun-ichiro Iemura, Naoto Ueno, Shunichi Shimasaki

Biochemical and Biophysical Research Communications 289 ( 5 ) 961 - 966 2001.12

Effect of Bone Morphogenetic Protein-7 on Folliculogenesis and Ovulation in the Rat1

Woo-Sik Lee, Fumio Otsuka, R. Kelly Moore, Shunichi Shimasaki

Biology of Reproduction 65 ( 4 ) 994 - 999 2001.10

Biological Function and Cellular Mechanism of Bone Morphogenetic Protein-6 in the Ovary

Fumio Otsuka, R. Kelly Moore, Shunichi Shimasaki

Journal of Biological Chemistry 276 ( 35 ) 32889 - 32895 2001.8

Chronic treatment with amlodipine modulates adrenocortical angiotensin II receptors in spontaneously hypertensive rats

Masayuki Kishida, Fumio Otsuka, Toshio Ogura, Hideo Kataoka, Yoshio Nakamura, Takayoshi Yamauchi, Masami Takahashi, Kazuaki Yokota, Yukari Mimura, Hirofumi Makino

Life Sciences 69 ( 1 ) 113 - 122 2001.5

Bone Morphogenetic Protein-15 Inhibits Follicle-stimulating Hormone (FSH) Action by Suppressing FSH Receptor Expression

Fumio Otsuka, Shin Yamamoto, Gregory F. Erickson, Shunichi Shimasaki

Journal of Biological Chemistry 276 ( 14 ) 11387 - 11392 2001.4

The role of nitric oxide and the renin-angiotensin system in salt-restricted Dahl rats

Hideo Kataoka, Fumio Otsuka, Toshio Ogura, Takayoshi Yamauchi, Masayuki Kishida, Masami Takahashi, Yukari Mimura, Hirofumi Makino

American Journal of Hypertension 14 ( 3 ) 276 - 285 2001.3

Coexistence of Graves' Disease and Struma Ovarii: Case Report and Literature Review.

YUKARI MIMURA, MASAYUKI KISHIDA, HISASHI MASUYAMA, NAOKO SUWAKI, JUNICHI KODAMA, FUMIO OTSUKA, HIDEO KATAOKA, TAKAYOSHI YAMAUCHI, TOSHIO OGURA, TAKAFUMI KUDO, HIROFUMI MAKINO

Endocrine Journal 48 ( 2 ) 255 - 260 2001

Japanese Family with Glucocorticoid-Remediable Aldosteronism Diagnosed by Long-Polymerase Chain Reaction.

Kazuaki YOKOTA, Toshio OGURA, Masayuki KISHIDA, Jiro SUZUKI, Fumio OTSUKA, Yukari MIMURA, Tetsuya OISHI, Makizo HIRATA, Kazuo TOBE, Hirofumi MAKINO

Hypertension Research 24 ( 5 ) 589 - 594 2001

Bone Morphogenetic Protein-15

Fumio Otsuka, Zuxu Yao, Taek-hoo Lee, Shin Yamamoto, Gregory F. Erickson, Shunichi Shimasaki

Journal of Biological Chemistry 275 ( 50 ) 39523 - 39528 2000.12

Differential effect of chronic inhibition of calcium channel and angiotensin II type 1-receptor on aldosterone synthesis in spontaneously hypertensive rats Reviewed

F Otsuka, T Ogura, H Kataoka, M Kishida, M Takahashi, Y Mimura, T Yamauchi, H Makino

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 74 ( 3 ) 125 - 136 2000.10

Language：English Publishing type：Research paper (scientific journal) Publisher：PERGAMON-ELSEVIER SCIENCE LTD

We have investigated the in vivo effect of chronic blockade of Ca2+-channels and angiotensin II type I (AT(1))-receptors on aldosterone (Aldo)-synthesis in the adrenal glands of spontaneously hypertensive rats (SHR). Male SHR were administered Ca2+-antagonist, amlodipine (10 mg/kg per day) or AT(1)-receptor-antagonist, TCV-116 (1 mg/kg per day) from 7 until 11 weeks of age. Systolic blood pressure (SBP) and heart rate (HR) were significantly higher in SHR than Wistar-Kyoto (WKY) rats. Both treatments resulted in equivalent and significant reduction in SEP in SHR. Aldo-secretion in SHR, which was significantly higher than in WKY rats, was profoundly suppressed by TCV-116 compared with amlodipine. Both treatments resulted in thickening of the tuna glomerulosa, which immunohistochemically contains Aldo, at the end of therapy. Competitive reverse transcription-polymerase chain reaction (RT-PCR) showed that CYP11A (P450scc) mRNA regulating the first step of Aldo-synthesis was significantly reduced from week 9 of age by amlodipine, and that CYP11A (P450aldo) mRNA regulating the last step of Aldo-synthesis was potently suppressed from 9 weeks of age by TCV-116. Our results indicate that chronic treatment with different antihypertensive agents directly modulates adrenocortical aldosterone synthesis in SHR in vivo via different mechanisms. (C) 2000 Elsevier Science Ltd. All rights reserved.

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Effects of angiotensin-converting enzyme inhibitor and α1-adrenoceptor antagonist on hypertension induced in rats by long-term inhibition of nitric oxide production

M. Takahashi, F. Otsuka, T. Ogura, T. Yamauchi, H. Kataoka, M. Kishida, Y. Mimura, H. Makino

Clinical and Experimental Nephrology volume 126 - 132 2000.6

Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

T. Ogura, K. Tobe, Y. Mimura, F. Otsuka, T. Yamauchi, A. Imai, C. Tsukamoto, Y. Iwasaki, K. Matsuura

Journal of Endocrinological Investigation 23 ( 4 ) 246 - 250 2000.4

Differential glomerular response to continuous infusion of vasopressin in spontaneously hypertensive rats and Wistar–Kyoto rats

Masayuki Kishida, Fumio Otsuka, Takayoshi Yamauchi, Toshio Ogura, Masami Takahashi, Hideo Kataoka, Yukari Mimura, Hirofumi Makino

Regulatory Peptides 87 ( 1-3 ) 25 - 32 2000.2

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