Faculty Profiles - OTSUKA Fumio

Papers - OTSUKA Fumio

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頭部外傷が契機と考えられる中枢性尿崩症の1例

山本紘一郎, 本多寛之, 田中秀一, 高橋美砂, 長谷川功, 中野靖浩, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 335 - 335 2022.4

LβT2細胞におけるオレキシンとBMPによるゴナドトロピン分泌調節の検討

副島佳晃, 岩田菜穂子, 中山菜々子, 平田真一, 中野靖浩, 山本紘一郎, 須山敦仁, 灘隆宏, 藤澤諭, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 329 - 329 2022.4

肝硬変と多発骨折を契機に診断されたFGF23関連低リン血症性骨軟化症の1例

須山敦仁, 山本紘一郎, 田中秀一, 孫麗那, 高橋美砂, 中野靖浩, 本多寛之, 長谷川功, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 325 - 325 2022.4

コロナ・アフターケア外来における加齢性腺機能低下(LOH)症候群の潜在とその特徴

山本幸近, 大塚勇輝, 徳増一樹, 中野靖浩, 本多寛之, 櫻田泰江, 砂田匠彦, 大村大輔, 長谷川功, 萩谷英大, 小比賀美香子, 植田圭吾, 片岡仁美, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 292 - 292 2022.4

骨粗鬆症精査を契機に診断されたTurner症候群の1成人例

長谷川徹, 越智可奈子, 中野靖浩, 山本紘一郎, 小比賀美香子, 植田圭吾, 長谷川高誠, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 402 - 402 2022.4

LβT2細胞におけるオレキシンとBMPによるゴナドトロピン分泌調節の検討

副島佳晃, 岩田菜穂子, 中山菜々子, 平田真一, 中野靖浩, 山本紘一郎, 須山敦仁, 灘隆宏, 藤澤諭, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 329 - 329 2022.4

IFN-α投与が奏効したステロイド抵抗性Erdheim-Chester病の1例

庵谷紘美, 中野靖浩, 中本健太, 平佑貴, 山本紘一郎, 長谷川功, 三好智子, 小川弘子, 白羽英則, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 279 - 279 2022.4

Cushing病術後にバセドウ病再燃と相対的副腎不全を来した1例

中野靖浩, 平佑貴, 中本健太, 庵谷紘美, 長谷川功, 大塚勇輝, 佐々木恵里佳, 岸田雅之, 大塚文男

日本内分泌学会雑誌 98 ( 1 ) 254 - 254 2022.4

ADHDの薬物治療強化により減量と血糖コントロールの改善が得られた若年肥満男性の1例

本多寛之, 大塚文男

糖尿病 65 ( Suppl.1 ) S - 233 2022.4

Detection of Male Hypogonadism in Patients with Post COVID-19 Condition. International journal

Yukichika Yamamoto, Yuki Otsuka, Naruhiko Sunada, Kazuki Tokumasu, Yasuhiro Nakano, Hiroyuki Honda, Yasue Sakurada, Hideharu Hagiya, Yoshihisa Hanayama, Fumio Otsuka

Journal of clinical medicine 11 ( 7 ) 2022.3

Language：English Publishing type：Research paper (scientific journal)

The pathogenesis and prognosis of post COVID-19 condition have remained unclear. We set up an outpatient clinic specializing in long COVID in February 2021 and we have been investigating post COVID-19 condition. Based on the results of our earlier study showing that "general fatigue" mimicking myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the most common symptom in long COVID patients, a retrospective analysis was performed for 39 male patients in whom serum free testosterone (FT) levels were measured out of 61 male patients who visited our clinic. We analyzed the medical records of the patients' backgrounds, symptoms and laboratory results. Among the 39 patients, 19 patients (48.7%) met the criteria for late-onset hypogonadism (LOH; FT < 8.5 pg/mL: LOH group) and 14 patients were under 50 years of age. A weak negative correlation was found between age and serum FT level (r = -0.301, p = 0.0624). Symptoms including general fatigue, anxiety, cough and hair loss were more frequent in the LOH group than in the non-LOH group (FT ≥ 8.5 pg/mL). Among various laboratory parameters, blood hemoglobin level was slightly, but significantly, lower in the LOH group. Serum level of FT was positively correlated with the levels of blood hemoglobin and serum total protein and albumin in the total population, whereas these interrelationships were blurred in the LOH group. Collectively, the results indicate that the incidence of LOH is relatively high in male patients, even young male patients, with post COVID-19 and that serum FT measurement is useful for revealing occult LOH status in patients with long COVID.

DOI： 10.3390/jcm11071955

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Low hematocrit reduces the efficiency of <scp>CD34</scp> ⁺ cell collection when using the Spectra Optia continuous mononuclear cell collection procedure

Takumi Kondo, Nobuharu Fujii, Keiko Fujii, Yuichi Sumii, Tomohiro Urata, Maiko Kimura, Masayuki Matsuda, Shuntaro Ikegawa, Kana Washio, Hideaki Fujiwara, Noboru Asada, Daisuke Ennishi, Hisakazu Nishimori, Ken‐ichi Matsuoka, Fumio Otsuka, Yoshinobu Maeda

Transfusion 2022.3

Hemothorax and Bloody Ascites Caused by Vascular Ehlers-Danlos Syndrome. International journal

Shuichi Tanaka, Hiroyuki Honda, Kou Hasegawa, Koji Tomita, Reimi Sogawa, Hideki Yamamoto, Takao Hiraki, Akira Hirasawa, Fumio Otsuka

The American journal of medicine 135 ( 7 ) e210-e211 2022.3

Idiopathic multicentric Castleman disease with positive antiphospholipid antibody: atypical and undiagnosed autoimmune disease?

Yoshito Nishimura, Asami Nishikori, Haruki Sawada, Torrey Czech, Yuki Otsuka, Midori Filiz Nishimura, Hiroki Mizuno, Naoki Sawa, Shuji Momose, Kumiko Ohsawa, Fumio Otsuka, Yasuharu Sato

Journal of clinical and experimental hematopathology : JCEH 2022.3

Language：English Publishing type：Research paper (scientific journal)

Idiopathic multicentric Castleman disease (iMCD) is a systemic disorder characterized by systemic inflammation and organ dysfunction associated with an increase in pro-inflammatory cytokines. Some patients with iMCD are positive for autoantibodies, although their significance and relationship with specific associated autoimmune diseases are unclear. This study retrospectively analyzed the clinicopathological features of iMCD patients focusing on autoantibodies. Among 63 iMCD patients in our database, 19 were positive for at least one autoantibody. Among the 19, we identified five with plasma cell type (PC)-iMCD lymph node histopathology and positive anti-phospholipid antibodies. These patients were likely to have thrombocytopenia, anasarca, fever, reticulin fibrosis or renal insufficiency, organomegaly (TAFRO) symptoms, and thrombotic events. The present study suggests that patients with undiagnosed or atypical autoimmune diseases, including anti-phospholipid syndrome (APS), were treated for iMCD. APS may present with thrombocytopenia or even multi-organ failure, which overlap with clinical presentations of iMCD. Due to differences in the treatment regimen and follow-up, recognition of the undiagnosed autoimmune disease process in those suspected of iMCD is essential. Our study highlights the importance of complete exclusion of differential diagnoses in patients with iMCD in their diagnostic workup.

DOI： 10.3960/jslrt.21038

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初期研修医の卒後ローテーションにおける「感染症研修の必須化」に関するアンケート調査

萩谷英大, 徳増一樹, 小比賀美香子, 大塚文男

感染症学雑誌 96 ( 2 ) 61 - 64 2022.3

Trends in the amyloidosis mortality rate in <scp>J</scp> apan: A nationwide observational study from 1998 to 2019

Ko Harada, Hideharu Hagiya, Toshihiro Koyama, Fumio Otsuka

Geriatrics & Gerontology International 22 ( 3 ) 246 - 250 2022.3

Language：English Publishing type：Research paper (scientific journal) Publisher：Wiley

AIM: Despite the increasing attention that has been paid to amyloidosis in recent years, there have been few reports on amyloidosis mortality and its trends worldwide. This study aimed to evaluate the trends in crude and age-adjusted amyloidosis-associated mortality rates in Japan from 1998 to 2019. METHODS: We used national Vital Statistics data among older adults aged over 50 years. The data were analyzed using the joinpoint regression program to estimate the long-term trends and average annual percentage changes (AAPCs). RESULTS: A total of 9158 amyloidosis-associated deaths were recorded from 1998 to 2019, of which 56.1% were in men. The crude mortality rate per 1 000 000 older adults aged over 80 years increased from 9.65 to 54.3 among men and from 7.02 to 22.1 among women during the study period. Overall, the AAPCs of age-adjusted amyloidosis-associated mortality rates increased significantly over the study period (1.8%, 95% confidence interval [CI], 1.0-2.7%). While the annual percentage change (APC) of age-adjusted mortality rates in women showed no significant change over the study period, the APC in men markedly increased in the 2013-2019 period (8.2%, 95% CI: 6.0-10.4%). CONCLUSIONS: This study revealed an increasing trend in mortality associated with amyloidosis, and in particular a marked increase in mortality among men over the past 6 years. Considering its high mortality rate and susceptibility to the effects of an increasing population of older adults, amyloidosis deserves more attention from healthcare providers to improve the understanding of diagnosis, clinical treatment, and healthcare planning. Geriatr Gerontol Int 2022; 22: 246-250.

DOI： 10.1111/ggi.14348

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Other Link： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ggi.14348

卵胞ステロイド合成におけるNR5Aの役割とClock・BMPによる調節機序

須山敦仁, 岩田菜穂子, 副島佳晃, 中野靖浩, 山本紘一郎, 灘隆宏, 大塚文男

日本内分泌学会雑誌 97 ( 5 ) 1303 - 1303 2022.3