Faculty Profiles - TSUKAHARA Hirokazu

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第1章輸液療法の基礎--新生児の輸液の特殊性を知る (新生児輸液マニュアル--早わかりポイント132)

塚原宏一

ネオネイタルケア 16 10 - 20 2003

Vasoactive and natriuretic mediators in umbilical cord blood: a report of our observation and review of the literature

H Tsukahara, K Sekine, M Miura, Y Todoroki, Y Ohshima, M Hiraoka, K Hosokawa, F Kotsuji, M Mayumi

EARLY HUMAN DEVELOPMENT 69 ( 1-2 ) 57 - 64 2002.10

Language：English Publisher：ELSEVIER SCI IRELAND LTD

Background: The relative potency and interrelationship among vasoactive and natriuretic mediators are thought to be important in the transition from fetal to neonatal life. However, little is known about their potential roles in the perinatal setting. Aim: The aim of this study was to evaluate further the potential roles of vasoactive and natriuretic mediators in the perinatal setting. Study design: We measured umbilical venous levels of arginine vasopressin, endothelin-1, adrenomedullin, natriuretic peptides and NO2-/NO3- in 24 vaginally delivered newborns and examined their possible functions. Results: Cord levels of vasopressin, endothelin-1 and adrenomedullin were considerably higher compared with normal adult values; the concentrations were more than 10-fold higher for vasopressin, and more than threefold higher for endothelin-1 and adrenomedullin. The levels of natriuretic peptides and NO2-/NO3- were almost comparable to those of normal adults. Among the mediators, there was a significant correlation between endothelin-1 and adrenomedullin. Conclusions: It appears from other studies that the postnatal fall in vasopressin and endothelin-1 levels is associated with increased levels of natriuretic peptides and NO2-/NO3-. Based on these observations, we consider that these mediators may play active roles in the initiation, maintenance or both of the transition from fetal to neonatal life. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

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Oxidant and antioxidant activities in childhood meningitis

H Tsukahara, T Haruta, Y Todoroki, M Hiraoka, E Noiri, M Maeda, M Mayumi

LIFE SCIENCES 71 ( 23 ) 2797 - 2806 2002.10

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Animal studies have provided substantial evidence for a key role of reactive oxygen species, nitric oxide and its related compounds in the complex pathophysiology of bacterial meningitis. However, there is little information on changes in the redox status in human meningitis. In the present study, we evaluated the redox status and oxidative stress in the central nervous system of children with meningitis. Oxidant and antioxidant activities were assessed from cerebrospinal fluid levels of acrolein-lysine adducts (a marker of lipid peroxidation), nitrite (a marker of nitric oxide production) and bilirubin derivatives (a marker of antioxidant activity of bilirubin). All these markers were several times higher in children during the early phase of bacterial meningitis compared with those of children without meningitis and patients with aseptic meningitis. In the bacterial meningitis group, the levels of bilirubin derivatives correlated significantly with those of acrolein-lysine adducts and nitrite. Acrolein-lysine adducts and nitrite decreased significantly as the patients started to respond to treatment but bilirubin derivatives remained elevated. In conclusion, our data indicate the enhancement of both oxidant and antioxidant activities in the central nervous system of children with early bacterial meningitis, but not in those with aseptic meningitis. Clinical and laboratory improvement may be associated with a decrease in oxidant activities in the central nervous system. (C) 2002 Elsevier Science Inc. All rights reserved.

DOI： 10.1016/S0024-3205(02)02137-9

Transient MR signal changes in the splenium of the corpus callosum in rotavirus encephalopathy: Value of diffusion-weighted imaging

R Kobata, H Tsukahara, A Nakai, A Tanizawa, Y Ishimori, Y Kawamura, H Ushijima, M Mayumi

JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 26 ( 5 ) 825 - 828 2002.9

Language：English Publisher：LIPPINCOTT WILLIAMS & WILKINS

The authors report serial brain MR findings from a 2-year-old girl with rotavirus encephalopathy. The lesion in the splenium of the corpus callosum showed restricted proton diffusion, suggesting local cytotoxic edema. Diffusion-weighted images demonstrated the lesion more conspicuously than other techniques, such as fluid-attenuated inversion-recovery and T1- and T2-weighted images. The findings were reversible on follow-up MRI obtained 4 days later. Diffusion-weighted MRI is a potentially useful method for detecting early changes of rotavirus encephalopathy, although the mechanism of the restricted diffusion is not clearly identified.

DOI： 10.1097/00004728-200209000-00028

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Erythromycin in ELBW infants [6]

Yuhko Shiima, Hirokazu Tsukahara, Ritsuyo Kobata, Kazuyo Hayakawa, Masahiro Hiraoka, Mitsufumi Mayumi

Journal of Pediatrics 141 ( 2 ) 297 - 298 2002.8

Augmentation of NO-mediated vasodilation in metabolic acidosis

K Hattori, S Tsuchida, H Tsukahara, M Mayumi, T Tanaka, L Zhang, T Taniguchi, Muramatsu, I

LIFE SCIENCES 71 ( 12 ) 1439 - 1447 2002.8

Language：English Publisher：PERGAMON-ELSEVIER SCIENCE LTD

Reduction of perivascular pH in acidemia produces hyporesponsiveness of vascular bed to vasoconstrictors. In the present study, we examined the effects of modest acidification on dilatory responses of isolated rat thoracic aorta. Acetylcholine produced endothelium-dependent relaxation in phenylephrine-precontracted aorta, which was markedly enhanced by acidification of Krebs-Henseleit solution from pH 7.4 to 7.0. A similar augmentation was observed in the relaxing responses to NO donors (SNP, SIN-1, SNAP), 8-Br-cGMP and NS-1619 (a putative K-Ca channel opener and/or Ca channel inhibitor) in endothelium-denuded, phenylephrine-contracted aorta. However, papaverine-induced relaxation was not affected by the change in pH. At pH 7.4, the relaxing responses to acetylcholine and SNP were partially inhibited by charybdotoxin (K-Ca channel inhibitor) but not glibenclamide (K-ATP channel inhibitor), while at pH 7.0 the relaxation induced by either drug was not affected by K+ channel inhibitors. Relaxation induced by 8-Br-cGMP or NS-1619 was not inhibited by charybdotoxin or glibenclamide. Acidification to pH 7.0 increased the cGMP production in response to acetylcholine in endothelium-intact aorta and to SNP in endothelium-denuded aorta. These results show that modest acidification augments NO-mediated relaxation in rat aorta, probably due to an enhancement of cGMP-dependent but K+ channel-unrelated relaxation mechanisms. (C) 2002 Elsevier Science Inc. All rights reserved.

DOI： 10.1016/S0024-3205(02)01914-8

Bone mineral status in ambulatory patients on long-term antiepileptic drug therapy. (vol 44, pg 247, 2002)

H Tsukahara, K Kimura, Y Todoroki, Y Ohshima, M Hiraoka, Y Shigematsu, Y Tsukahara, M Miura, M Mayumi

PEDIATRICS INTERNATIONAL 44 ( 4 ) 466 - 466 2002.8

Infantile renal dysfunction associated with intrauterine exposure to ritodrine and magnesium sulfate

N Ohta, H Tsukahara, N Yamashita, R Kobata, M Hiraoka, K Shukunami, K Hosokawa, F Kotsuji, M Mayumi

NEPHRON 91 ( 2 ) 352 - 353 2002.6

原発性巣状糸球体硬化症患児におけるメチレンテトラヒドロフォレート還元酵素遺伝子多型の解析 (主題腎・尿路疾患)

Zou Chaochun, 塚原宏一, 平岡政弘

小児科臨床 55 ( 6 ) 945 - 948 2002.6

慢性肺疾患の薬物療法--生後早期ステロイド療法 (特集新生児の慢性肺疾患)

塚原宏一

周産期医学 32 ( 6 ) 777 - 784 2002.6

髄膜炎の発症と一酸化窒素(NO)

塚原宏一

小児感染免疫 14 ( 1 ) 31 - 39 2002.4

急性脳症を発症したSalmonella enteritidis腸炎の1例

山下信子, 塚原宏一, 川満徹, 西田公一, 大嶋勇成, 平岡政弘, 眞弓光文, 平泉泰

小児感染免疫 14 ( 1 ) 57 - 57 2002.4

Two cases of anaphylactic reaction to gelatin induced by a chloral hydrate suppository

A Yamada, Y Ohshima, H Tsukahara, M Hiraoka, Kimura, I, T Kawamitsu, K Kimura, M Mayumi

PEDIATRICS INTERNATIONAL 44 ( 1 ) 87 - 89 2002.2

気管支喘息治療中に舞踏アテトーゼ様症状を呈した１例

小倉一将, 大嶋勇成, 畑郁江, 小俣合歓子, 安冨素子, 塚原宏一, 谷澤昭彦, 平岡政弘, 眞弓光文

日本小児アレルギー学会誌 16 ( 2 ) 175 - 159 2002

Language：Japanese Publisher：(一社)日本小児アレルギー学会

4歳女児.主訴は右上下肢の不随意運動.アレルギー性鼻炎と気管支喘息を有しており,オキサトミド投与を7日間受けた後,喘息発作出現のためテオフィリン内服に変更され,投与開始3日目に右上下肢の舞踏アテトーゼ様不随意運動が出現した.不随意運動は投薬中止後2週間で消失し,以後の経過観察で再発を認めていない.paroxysmal dystonic choreoathetosis類似の病態がオキサトミドとテオフィリンの投与が契機となって生じた可能性が考えられた

DOI： 10.3388/jspaci.16.175

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2002&ichushi_jid=J02137&link_issn=&doc_id=20020703210008&doc_link_id=10.3388%2Fjspaci.16.175&url=https%3A%2F%2Fdoi.org%2F10.3388%2Fjspaci.16.175&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

Gas-phase oxidation and disproportionation of nitric oxide

H Tsukahara, T Ishida, M Mayumi

NITRIC OXIDE, PT D 359 168 - 179 2002

An Infantile Case of Partial Trisomy 4q Resulting from 46, XY. ish der (13) ins (13 ; 4) (q12.1 ; q25q35) (wcp4+, wcpl3+, LSI13+)

TODOROKI Yukiko, TSUKAHARA Hirokazu, SHIGEMATSU Yosuke, OBATA Koichiro, KOBATA Ritsuyo, ONO Nemuko, FUJISAWA Kazuo, HIRAOKA Masahiro, HORI Chikahide, MAYUMI Mitsufumi

105 ( 7 ) 785 - 788 2001.7

【腎・尿路疾患】肉眼的血尿を契機に発見された水腎症の1例

大坂陽子, 塚原宏一, 山田直江, 巨田尚子, 山下信子, 平岡政弘, 眞弓光文

小児科臨床 54 ( 7 ) 1478 - 1480 2001.7

Language：Japanese Publisher：(株)日本小児医事出版社

8歳男児.肉眼的血尿及び異常腹部腫瘤の精査目的で入院した.腹部超音波検査で両側腎盂の拡張(右腎は軽度,左腎は重度)が認められた.フロセミド負荷99mTc-DTPA腎臓シンチグラフィでは尿停滞が存在したが(左腎でより重度),それはフロセミドにより部分的に解除された.MRウログラフィでも左腎盂での重度の尿停滞が認められた.逆行性膀胱造影では異常は認められなかった.異常腹部腫瘤は左側尿管腎盂移行部狭窄による水腎症と診断した

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Other Link： http://search.jamas.or.jp/link/ui/2002031115

外陰部異常を呈し巣状糸球体硬化症から腎不全に至ったFrasier症候群の1男児例

山下信子, 平岡政弘, 西田公一, 大阪陽子, 塚原宏一, 眞弓光文

日本小児科学会雑誌 105 ( 2 ) 205 - 205 2001.2

全身性炎症性疾患における一酸化窒素(NO)の病態生理学的意義

塚原宏一

日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology 14 ( 3 ) 352 - 352 2000.10

Streptococcus pneumoniae-induced acute renal failure in a neonate

N Tomida, H Tsukahara, T Hiragi, N Ono, Y Osaka, M Hiraoka, M Mayumi

NEPHRON 86 ( 2 ) 190 - 191 2000.10

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