Faculty Profiles - TSUKAHARA Hirokazu

MISC - TSUKAHARA Hirokazu

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Changes of plasma coenzyme Q(10) levels in early infancy

S Sato, H Tsukahara, Y Ohshima, N Ohta, M Uchiyama, K Sekine, T Uetake, M Mayumi

REDOX REPORT 9 ( 5 ) 289 - 290 2004

Language：English Publisher：MANEY PUBLISHING

Rapid perfusion of oxygen in infants at birth may increase oxidative stress which has been incriminated in serious diseases including neonatal respiratory distress syndrome, chronic lung disease, and retinopathy of prematurity. Elucidating the antioxidant defense systems of neonates in clinical practice is important. Coenzyme Q(10) is a widely distributed, redox-active quinoid compound originally discovered as an essential part of the mitochondrial respiratory chain in mammals. Although coenzyme Q(10) is a powerful lipid antioxidant in vivo, few data pertain to plasma CoQ(10) levels in infants. This is the first paper to report plasma coenzyme Q(10) levels in preterm infants.

DOI： 10.1179/135100004225006768

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薬剤の胎児腎への影響：リトドリン、マグネシウム

塚原宏一

日本小児腎不全学会雑誌 24 30 - 34 2004

新生児単純ヘルペスウイルス感染症を呈した超低出生体重児の１例

早川和代, 畑郁江, 古畑律代, 山田直江, 川谷正男, 金谷由宇子, 塚原宏一, 谷澤昭彦, 眞弓光文

日児誌 108 ( 5 ) 782 - 785 2004

早産児の骨代謝マーカーとDXAを用いた骨量計測

塚原宏一

第4回新生児栄養フォーラム発表論文集 85-101 2004

アレルギーと酸化ストレス

塚原宏一, 眞弓光文

日児誌 108 ( 5 ) 744 - 752 2004

Acute bilateral medial medullary infarction: A unique 'heart appearance' sign by diffusion-weighted imaging

M Maeda, T Shimono, H Tsukahara, SE Maier, K Takeda

EUROPEAN NEUROLOGY 51 ( 4 ) 236 - 237 2004

Methylenetetrahydrofolate reductase polymorphism in patients with bronchial asthma

Mizu Jiang, Hirokazu Tsukahara, Yusei Ohshima, Chaochun Zou, Naoko Ohta, Shuko Sato, Yukiko Todoroki, Masahiro Hiraoka, Mitsuhiko Nambu, Toshio Tanaka, Etsuro Yamaguchi, Naomi Kondo, Mitsufumi Mayumi

International Medical Journal 11 ( 2 ) 119 - 123 2004

Objective: Bronchial asthma is a chronic inflammatory condition of the respiratory tract. The C677T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene is reported to confer susceptibility to cardiovascular diseases and inflammatory conditions. We hypothesized that TT genotype of MTHFR may influence the development of bronchial asthma and thus examined the C677T polymorphism in our Japanese asthmatic patients. Design: Clinical Investigation. Methods: Genotypes for MTHFR were determined in 461 asthmatic patients (male/female ratio: 248/213) by the polymerase chain reaction and restriction fragment length polymorphism method and the results were compared with those obtained from 1430 healthy subjects (male/female ratio: 939/491). Results: For the male population, the frequency of the TT genotype in asthmatic patients was significantly higher than in healthy subjects (16.9% vs. 11.0%, odds ratio = 1.65, 95% confidence interval: 1.12-2.44, P = 0.011). For the female population, the frequency of the TT genotype in atopic asthmatic patients was insignificantly higher than in non-atopic asthmatic patients (17.3% vs. 11.8%). Conclusion: Our findings suggest that the TT genotype of MTHFR is a probable genetic risk factor for the development of bronchial asthma in Japanese males.

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Mobilizationの責任

塚原宏一

平成16年度福井県小児科医会会報33号 177 2004

小児疾患シリーズ（小児救急の手引き8）：ショック

塚原宏一, 眞弓光文

臨床医薬 20 ( 7 ) 795 - 805 2004

エンドセリン/エンドセリン受容体系の骨格系における生物学的役割

塚原宏一

第20回小児代謝性骨疾患研究会発表論文集 89 - 93 2004

An extremely low birthweight infant with metaphyseal osteopenia in long bones possibly due to maternal administration of magnesium sulphate

H.Tsukahara, N.Yamada, H.Kometani, Y.Kanaya, N.Ohta, S.Sato, A.Tanizawa, M.Mayumi

Repots for 21st Pediatric Metabolic Bone Disease Conference 45 - 48 2004

壊死性腸炎を呈するミルクアレルギーの新生児症例についての検討

塚原宏一

小児科臨床 57(2) ( 2 ) 273 - 276 2004

レドックス制御が急性肺傷害におよぼす治療的効果（研究課題番号 14370244）

眞弓光文, 塚原宏一

平成14～15年度科学研究費補助金 (基盤研究B2) 研究成果報告書 2004

乳児期早期の児における血漿中coenzyme Q10値の計測

佐藤周子, 塚原宏一, 大嶋勇成, 巨田尚子, 轟夕起子, 田村知史, 関根恭一, 西井学, 小川泰代, 内山真由美, 針田恭子, 黒瀬ルミ子, 植竹達雄, 眞弓光文

小児科臨床 57(9) ( 9 ) 1913 - 1917 2004

Language：Japanese Publisher：(株)日本小児医事出版社

正期産児5名,早産児15名について血漿中Coenzyme Q10(CoQ10)値の生後変化を調査した.生直後に呼吸障害を呈さなかった群(呼吸障害なし群,11名),呼吸障害を呈し酸素補充と人工換気療法を必要とした群(呼吸障害あり群,9名)とも,生直後においては血漿中CoQ10値が健常成人レベルを下回る児がほとんどであった.CoQ10値はその後上昇し,呼吸障害なし群では新生児期の後半に,呼吸障害あり群では新生児期を過ぎたころに健常成人レベルに達していた.母乳・人工粉乳中にも新生児血漿中とほぼ同レベルのCoQ10が含有されていた.これらの結果から,CoQ10がレドックス制御系(酸化ストレスに対する防御機構として種々の生体内還元装置が作動するシステム)の生後成熟に寄与している可能性が示唆された

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2004&ichushi_jid=J00643&link_issn=&doc_id=20040831220003&doc_link_id=%2Fag1snrsd%2F2004%2F005709%2F004%2F1913-1917%26dl%3D0&url=http%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fag1snrsd%2F2004%2F005709%2F004%2F1913-1917%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Oxidative stress in the pathogenesis of diabetic complications

TSUKAHARA H.

Recent Research Developments in Life Sciences 2 111 - 120 2004

Role of oxidative stress in allergic inflammation

TSUKAHARA H.

Recent Research Developments in Life Sciences 2 183 - 193 2004

High levels of urinary pentosidine, an advanced glycation end product, in children with acute exacerbation of atopic dermatitis: Relationship with oxidative stress

H Tsukahara, R Shibata, N Ohta, S Sato, M Hiraoka, S Ito, E Noiri, M Mayumi

METABOLISM-CLINICAL AND EXPERIMENTAL 52 ( 12 ) 1601 - 1605 2003.12

Language：English Publisher：W B SAUNDERS CO

Pentosidine is an advanced glycation end product formed by sequential glycation and oxidation. The formation of pentosidine is increased in diseases associated with oxidative stress, such as inflammatory conditions. The aim of the present study was to determine the urinary concentration of pentosidine in atopic dermatitis (AD) and its relationship to the inflammatory status of AD. Urine samples of 32 children with AD and 30 age-matched healthy control subjects were assayed for pentosidine, pyrraline (another advanced glycation end product formed by nonoxidative glycation), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) (an established marker of oxidative stress). Of these 3 markers, urinary concentrations of pentosidine were significantly higher in patients with acute exacerbation of AD than in healthy controls and patients with stable AD. Urinary concentrations of 8-OHdG were significantly higher in AD patients with and without acute exacerbation than in healthy controls. Urinary pentosidine levels correlated significantly with those of 8-OHdG when all data of healthy controls and AD patients were plotted. In patients with acute exacerbation of AD, both urinary pentosidine and 8-OHdG significantly decreased after 7 to 9 days of treatment. Our findings in patients with acute exacerbation of AD suggest that pentosidine levels are partly determined by the prevailing oxidative stress in these patients. (C) 2003 Elsevier Inc. All rights reserved.

DOI： 10.1016/S0026-0495(03)00310-X

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Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes.

H Tsukahara, Hata, I, Y Todoroki, M Hiraoka, M Mayumi, M Uchiyama, H Kawakami, K Sekine, K Yoshihara, M Beppu

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14 400A - 400A 2003.11

Formation of advanced glycosylation end products and oxidative stress in young patients with type 1 diabetes

H Tsukahara, K Sekine, M Uchiyama, H Kawakami, Hata, I, Y Todoroki, M Hiraoka, M Kaji, T Yorifuji, T Momoi, K Yoshihara, M Beppu, M Mayumi

PEDIATRIC RESEARCH 54 ( 3 ) 419 - 424 2003.9

Language：English Publisher：INT PEDIATRIC RESEARCH FOUNDATION, INC

Increased production of advanced glycosylation end products (AGEs) and augmented oxidative stress may contribute to vascular complications in diabetes. Little is known about the formation and accumulation of AGEs in young patients with type I diabetes. The aim of the present study was to investigate whether AGE production and oxidative stress are augmented in young patients with type I diabetes at early clinical stages of the disease. Urine samples of 38 patients with type I diabetes [mean age (+/-SD), 12.8 +/- 4.5 y; diabetes duration, 5.7 +/- 4.3 y; HbA(1c), 8.0 +/- 1.6%; urinary albumin excretion, 12.6 +/- 14.4 mg/g creatinine (Cr)] and those of 60 age-matched healthy control subjects were assayed for AGEs, pentosidine and pyrraline, and markers of oxidative stress, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and acrolein-lysine. Of these four markers, urinary concentrations of pentosidine, 8-OHdG, and acrolein-lysine were significantly higher in the patients with diabetes than in the healthy control subjects. For the patient group, pentosidine correlated significantly with 8-OHdG and acrolein-lysine, and pyrraline correlated significantly with acrolein-lysine. Urinary pentosidine, 8-OHdG, and acrolein-lysine but not pyrraline correlated significantly with urinary albumin excretion. Patients with microalbuminuria ( greater than or equal to15 mg/g Cr) showed significantly higher levels of all four markers than did normoalbuminuric patients and control subjects. The present study indicates that accumulation of AGEs, whose formation is closely linked to oxidative stress, and resultant endothelial dysfunction may start early in the course of type I diabetes. This means that the risk of vascular complications may be present at an early age and that the best possible glycemic control should be emphasized from the diagnosis of diabetes.

DOI： 10.1203/01.PDR.0000076662.72100.74

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Transient splenial lesion of the corpus callosum associated with antiepileptic drugs: evaluation by diffusion-weighted MR imaging

M Maeda, T Shiroyama, H Tsukahara, T Shimono, S Aoki, K Takeda

EUROPEAN RADIOLOGY 13 ( 8 ) 1902 - 1906 2003.8

Language：English Publisher：SPRINGER-VERLAG

Transient focal lesions in the splenium of the corpus callosum have been reported in epileptic patients receiving antiepileptic drugs. The characteristic imaging features included an oval high signal lesion on T2-weighted images in the central part of the splenium, no enhancement on post-contrast MR images, and complete reversibility without specific treatment. We report identical MR imaging findings in a depressive patient who had received antiepileptic drugs. In addition, diffusion-weighted MR imaging findings are described in our case, which is the first report on this unique lesion associated with antiepileptic drugs. Although this lesion has been assumed to be vasogenic edema in the previous reports, diffusion-weighted MR imaging showed markedly restricted diffusion of the lesion in the present case, suggesting that cytotoxic edema was the main pathophysiological abnormality.

DOI： 10.1007/s00330-002-1679-5

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