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村上純, 浅海淳一, 柳文修, 此内浩信

歯科放射線 47 ( 1-4 ) 113 - 113 2008年3月

Diagnostic value of dynamic contrast-enhanced MRI in the salivary gland tumors. 国際誌

Miki Hisatomi, Jun-ichi Asaumi, Yoshinobu Yanagi, Teruhisa Unetsubo, Yuu Maki, Jun Murakami, Hidenobu Matsuzaki, Yasutoshi Honda, Hironobu Konouchi

Oral oncology 43 ( 9 ) 940 - 7 2007年10月

記述言語：英語出版者・発行元：ELSEVIER SCIENCE BV

To evaluate the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI) in salivary gland tumors, thirty-five patients (47 lesions) who underwent MR examinations and were histopathologically diagnosed with salivary gland tumors in Okayama University Hospital, between April 1998 and March 2005, were entered in the present study. The parameters included CI(max300) or CI(max600), which was the contrast index (CI) at maximal contrast enhancement upon 300 s or 600 s, and Tmax, which was the time that corresponded to the CI(max300). Washout ratio (WR(300) or WR(600)) was defined as follows: CI(max300)-CI(300s)/CI(max300) or CI(max600)-CI(600s)/CI(max600)x100 (%), where CI(300) or CI(600) was the CI at 300s or 600s after contrast medium administration. We obtained the following results from the analysis of DCE-MRI parameters; (a) The salivary gland tumors were categorized into three CI curve types according to Tmax and WR300; Pleomorphic adenoma; Tmax > 210 s and WR300 < 10%, Warthin tumor; Tmax < 60 s and WR300 > 40%, and malignant tumor; 60s < Tmax < 210 s and 10% < WR300 < 30%; (b) On the basis of the relationship between Tmax and CImax or WR, all pleomorphic adenomas were successfully differentiated from Warthin tumor lesions. Of the 20 pleomorphic adenomas, 18 (90.0%) were successfully differentiated from malignant tumors. All Warthin tumor lesions were successfully differentiated from pleomorphic adenomas and malignant tumors. Of 12 the malignant tumors, 11 (91.7%) were successfully differentiated from pleomorphic adenomas. All malignant tumors were successfully differentiated from Warthin tumors. Thus, DCE-MRI parameters are useful in diagnosing salivary gland tumors on the basis of the combined assessment of Tmax and CImax or WR.

DOI： 10.1016/j.oraloncology.2006.11.009

Web of Science

PubMed

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残存歯数・歯の残存部位と年齢の関係について

畦坪輝寿, 浅海淳一, 久富美紀, 柳文修, 此内浩信

日本口腔診断学会雑誌 20 ( 2 ) 455 - 455 2007年10月

Diagnosis of multiple synchronously occurring cystic jaw lesions in 23 patients: Prognostic implications related to basal cell nevus syndrome

Jun-Ichi Asaumi, Jun Murakami, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Yuu Maki, Teruhisa Unetsubo, Yasutoshi Honda, Hironobu Konouchi

Oral Radiology 23 ( 1 ) 16 - 18 2007年6月

記述言語：英語

Objectives. We rarely find multiple cystic lesions in the jaw in panoramic radiographs. Most reports of multiple cystic lesions have described keratocystic odontogenic tumors (KOTs) in patients with basal cell nevus syndrome. In this study, we performed radiographic and clinical examinations of patients with multiple cystic jaw lesions found during their first visit to our department to determine the proportion of basal cell nevus syndrome among multiple cystic lesions. Methods. Patients who had a panoramic radiograph taken at Okayama University Hospital between 1993 and 2000 were examined. Twenty-three patients with multiple cystic jaw lesions on a first panoramic radiography examination were entered into this study. Results. Of the 23 patients, 12 (52.2%) were diagnosed with basal cell nevus syndrome and 11 (47.8%) were not. Of the 14 patients with multiple KOTs, 12 (85.7%) were diagnosed as having basal cell nevus syndrome. Of the nine remaining patients with multiple cystic jaw lesions, only seven had multiple dentigerous cysts and two had multiple simple bone cysts. Cleft palate was observed in four of the 12 patients (33.3%) with basal cell nevus syndrome. Conclusion. Diagnosing basal cell nevus syndrome based on multiple cystic jaw lesions carries a high risk of misdiagnosis. A strong possibility exists that patients with multiple jaw KOTs have basal cell nevus syndrome. Furthermore, cleft palate should be considered an important oral finding in basal cell nevus syndrome because its occurrence was relatively frequent in our study. © 2007 Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag.

DOI： 10.1007/s11282-007-0059-x

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Novel cell-surface peptides specific to human oral squamous cell carcinoma using an E-coli peptide display library

Noriko Kawai, Junichi Asaumi, Jun Murakami, Toru Wakasa, Masahiro Kuroda, Miki Hisatomi, Teruhisa Unetsubo, Yuu Maki, Hidenobu Matsuzaki, Yoshinobu Yanagi, Hironobu Konouchi

ONCOLOGY REPORTS 17 ( 4 ) 787 - 791 2007年4月

記述言語：英語出版者・発行元：PROFESSOR D A SPANDIDOS

We attempted to find a specific antigen of oral squamous cell carcinoma (SCC) cells that could be safely applied to gene therapy in the conservative clinical treatment of oral cancer. We performed subtraction using normal human keratinocyte cells, followed by selection using four oral SCC cell lines. We isolated three clones from poorly differentiated SCC cells and four from well-differentiated SCC cells. These seven clones adsorbed to the oral SCC cells at rates 10-100 times those of normal human keratinocyte cells. The three clones from the poorly differentiated SCC cells showed the same peptide sequence (LAPRTHP). Of the four clones from the well-differentiated SCC cells, three showed the same peptide sequence (FGTLPGT) and the fourth showed a different one (VTPNSTP). Each peptide sequence may recognize the material that exists specifically on the oral SCC cell cortex. We can expect applications not only for tumor-targeting treatment using a gene therapy virus vector but also for diagnosis using, as a tumor marker, the peculiar SCC surface material that these peptides recognize.

DOI： 10.3892/or.17.4.787

小型MRI装置の作製矩形ファントムの画像再構成

加藤博和, 花元克巳, 澁谷光一, 川崎祥二, 黒田昌宏, 金澤右, 柳文修, 本多康聡, 岸幹二, 高橋則雄, 綾野成記, 芝潤, 金澤圭剛

Radiation Medicine 25 ( Suppl.I ) 92 - 92 2007年4月

Open-configuration MRIを用いた座位での嚥下動態の評価

本多康聡, 波多伸彦, 柳文修, 浅海淳一

日本画像医学雑誌 25 ( 3 ) 176 - 176 2007年2月

MRIデータに基いた舌・喉頭部の生理学的嚥下モデルの構築

本多康聡, 党建武, 柳文修, 浅海淳一, 藤田覚

日本画像医学雑誌 25 ( 3 ) 166 - 166 2007年2月

院内連携による睡眠時無呼吸症候群診療への取り組み

公文啓二, 小川晃弘, 柴田泰弘, 柳文修, 福本初, 正木昭次

ＭｅｄｉｃａｌＱＯＬ 153 24 - 27 2007年

閉塞型睡眠時無呼吸症候群に伴う睡眠時の多発性心室性期外収縮が口腔内装置治療によって消失した1症例

公文啓二, 小川晃弘, 柴田康弘, 柳文修, 福本初, 正木昭次

循環制御 27 ( 4 ) 358 - 361 2006年12月

記述言語：日本語出版者・発行元：日本循環制御医学会

47歳女、日中の強度の眠気、入浴中の睡眠発作様症状、いびきを訴えた。標準終夜睡眠ポリグラフ(PSG)による無呼吸低呼吸指数は軽症の閉塞型無呼吸症候群を示したが、症状は強く危険な閉塞型睡眠時無呼吸症候群の状態であった。また、多発性の心室性期外収縮(VPCs)を認めた。cephalometryによる顔面角では86度と下顎の後方偏移は乏しかったが、口腔内装具(ORAP)療法を導入し、歯科にて50%下顎前方固定のORAPを作成した。ORAP装着下のPSGでは著明な改善を認め、VPCsは消失した。症状は全て解消し、生活の質の改善を得た。

DOI： 10.11312/ccm.27.358

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その他リンク： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2006&ichushi_jid=J00631&link_issn=&doc_id=20061229390012&doc_link_id=10.11312%2Fccm.27.358&url=https%3A%2F%2Fdoi.org%2F10.11312%2Fccm.27.358&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

小児患者におけるパノラマエックス線写真のスクリーニングとしての意義

畦坪輝寿, 浅海淳一, 久富美紀, 柳文修, 此内浩信, 岸幹二

日本口腔診断学会雑誌 19 ( 2 ) 398 - 398 2006年10月

Enhancement effects of test injection with a small amount of MR contrast medium in the oral and maxillofacial region. 国際誌

Yoshinobu Yanagi, Jun-ichi Asaumi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Jun Murakami, Yuu Maki, Teruhisa Unetsubo, Kanji Kishi

European journal of radiology 59 ( 3 ) 367 - 70 2006年9月

記述言語：英語出版者・発行元：ELSEVIER IRELAND LTD

PURPOSE: To examine whether the signal intensity of dynamic contrast-enhanced MRI (DCE-MRI) is altered by test injection of 1 ml of contrast medium, and if so, whether this change affects the DCE-MRI analysis. MATERIALS AND METHODS: Six healthy volunteers were examined by DCE-MRI using a Magnevist syringe and/or an Omniscan syringe for the injection of contrast medium. Each scan was performed 10 times using steady-state free precession (3D-FISP), a sequence for DCE-MRI, before and after intravenous injection of 1 ml of the contrast medium. The internal pterygoid muscle, masseter muscle, tongue, parotid gland, submandibular gland, bone marrow of the mandible, subcutaneous adipose tissue, and common carotid artery were determined to be regions of interest (ROI), and the ROI internal average signal intensity was measured. The 10 data sets obtained before or after contrast medium administration for each ROI were evaluated using the paired t-test. RESULTS: The test injection increased the signal intensities of six of eight ROIs, with all 20 experiments in the submandibular gland showing significant differences. There was no significant difference in the two ROIs corresponding to the carotid artery and subcutaneous adipose tissue of the cheek. CONCLUSIONS: The enhanced signal intensity in the tissue might have been caused by the small amount of contrast medium in the test injection. To eliminate this discrepancy caused by the test injection, a pre-contrast scan should be performed when the average signal intensity of an ROI is measured. We therefore believe that the data obtained before a test injection may be important in the analysis of DCE-MRI.

DOI： 10.1016/j.ejrad.2006.03.017

Web of Science

PubMed

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歯学系OSCEにおける医療面接評価教員と模擬患者の評価の信頼性とその関連性

吉田登志子, 浅海淳一, 松村誠士, 目瀬浩, 柳文修, 此内浩信, 仲井雪絵, 白井肇, 鳥井康弘, 荒川光, 前田純子, 下野勉

医学教育 37 ( Suppl. ) 91 - 91 2006年7月

Usefulness of contrast enhanced-MRI in the diagnosis of unicystic ameloblastoma. 国際誌

Hironobu Konouchi, Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Noriko Kawai, Hidenobu Matsuzaki, Kanji Kishi

Oral oncology 42 ( 5 ) 481 - 6 2006年5月

記述言語：英語出版者・発行元：ELSEVIER SCIENCE BV

The radiographic features of unicystic ameloblastoma (UA) are typically unilocular and round area of radiolucency. Therefore, this type of lesion is often misdiagnosed as an odontogenic keratocyst or a dentigerous cyst. UA should be differentiated from odontogenic cysts because the former have a higher rate of recurrence than the latter. In the present study, we performed contrast enhanced-MRI (CE-MRI) to diagnose 13 cases of unilocular, round radiolucent lesions visualized on panoramic radiograph and/or CT. In the cases of UA, low signal intensity was observed on T1-weighted images (WIs), and a markedly high signal intensity was observed on T2-WIs; moreover, relatively thick rim-enhancement with/without small intraluminal nodules was observed upon CE-T1WIs. CE-MRI was considered useful in the diagnosis of UA, as characteristic features of this type of lesion i.e., thick enhancement of the tumor wall and small intraluminal nodules were detected only by CE-MRI in the present study.

DOI： 10.1016/j.oraloncology.2005.10.001

顎関節MRIを用いた関節円板動態診断の変動と信頼性

永松千代美, 小野剛, 前川賢治, 柳文修, 浅海淳一, 荒木佳子, 片山朗, 谷本裕子, 宮脇正一, 山本照子, 岸幹二, 窪木拓男

日本顎関節学会雑誌 18 ( 1 ) 60 - 60 2006年4月

A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after the initial treatment

YS Choi, J Asaumi, Y Yanagi, M Hisatomi, H Konouchi, K Kishi

DENTOMAXILLOFACIAL RADIOLOGY 35 ( 1 ) 43 - 46 2006年1月

記述言語：英語出版者・発行元：BRITISH INST RADIOLOGY

A case of recurrent ameloblastoma developing in an autogenous iliac bone graft 20 years after radical resection of primary mandibular ameloblastoma is presented. This case showed extensive bony resorption extending throughout the auto-grafted bone. Seeding to the graft bone was suspected as a cause of the recurrence in the iliac bone graft because wide destruction of the graft bone was observed without any prior signs and symptoms of intraoral mucosa. Consequently, extensive resection of bone as well as adjacent soft tissue was performed. Persistent follow-up examination is essential for management of ameloblastoma.

DOI： 10.1259/dmfr/13828255

嚥下時における舌圧と咽頭内圧の関連について舌圧・咽頭内圧測定システムの構築

有岡享子, 石田瞭, 柳文修, 浅海淳一, 江草正彦, 嶋田昌彦, 岸幹二

岡山歯学会雑誌 24 ( 2 ) 53 - 59 2005年12月

記述言語：日本語出版者・発行元：岡山歯学会

舌圧・咽頭内圧測定を指標とした同時圧測定システムの構築を行った.著しい歯列不正,構音障害,嚥下障害のない健康成人10例を対象とした.アルジネート印象材で個人の上顎の印象を採得し,石膏模型を作製した.この模型から樹脂プレートにより口蓋床を作製し,これに圧測定用マイクロシリコンチューブを埋入して使用した.比較的安定した舌圧,咽頭内圧の測定が可能で,それぞれの最大圧値のパターン化を行うことができた.また,咽頭内圧発生時の舌圧の必要性が示唆された.舌圧,咽頭内圧の同時測定,解析は嚥下動態を知るために有用であることが示唆された

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好酸球肉芽腫の臨床的・X線学的検討

浅海淳一, 畦坪輝寿, 牧優, 村上純, 松崎秀信, 久富美紀, 河井紀子, 柳文修, 此内浩信, 岸幹二

岡山歯学会雑誌 24 ( 2 ) 37 - 41 2005年12月

記述言語：日本語出版者・発行元：岡山歯学会

病理組織学的に好酸球肉芽腫と診断した4例を対象とした.主訴は4例中2例が腫脹,1例が疼痛,1例がX線撮影時に偶然発見されたものであった.臨床的・X線学的に4例中2例は悪性腫瘍,1例は骨髄炎と診断され,1例は不明であった.最終的には病理組織学的に全例,好酸球肉芽腫と診断した.X線学的には,顎骨内に生じた14病巣はび漫性のX線透過像を示した.処置は8病巣で掻爬あるいは辺縁骨切除などの外科処置,4病巣で放射線照射,3病巣で化学療法,2病巣で外科処置と放射線照射,3病巣で放射線照射と化学療法を行った.いずれの処置に対してもよく反応したが,化学療法に関しては悪性リンパ腫の診断の基に行ったもので,反応は悪かった.外科処置のみを行った4病巣に再発を生じたが,放射線照射および外科処置と放射線照射の併用によって制御された

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小児患者におけるパノラマエックス線写真のスクリーニングとしての意義

村中アドリアナ, 浅海淳一, 久富美紀, 柳文修, 此内浩信, 岸幹二

歯科放射線 45 ( 4 ) 180 - 180 2005年12月

舌癌における原発部ドップラ超音波画像と所属リンパ節転移の関係について

河井紀子, 柳文修, 松崎秀信, 此内浩信, 浅海淳一, 本多康聡, 久富美紀, 村上純, 岸幹二

歯科放射線 45 ( 4 ) 198 - 198 2005年12月

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