研究者詳細 - 柳　文修

MISC - 柳　文修

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Application of dynamic contrast-enhanced MRI to differentiate malignant lymphoma from squamous cell carcinoma in the head and neck. 国際誌

Jun-Ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Miki Hisatomi, Hidenobu Matsuzaki, Kanji Kishi

Oral oncology 40 ( 6 ) 579 - 84 2004年7月

記述言語：英語出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

Because malignant lymphoma, the second most common malignant tumor of the head and neck, and squamous cell carcinoma (SCC), the most common malignant tumor of the head and neck, require different treatments, it is important to be able to differentiate them. In the present study, we attempted to differentiate malignant lymphomas from SCCs using dynamic contrast-enhanced MRI (DCE-MRI). Seventeen lesions (in 8 cases) of malignant lymphoma and 30 cases of SCC were compared by DCE-MRI. Thirteen of 17 malignant lymphomas (76.5%) showed the maximum contrast index (CI) at 90-180 s, while 26 of 30 SCCs (86.7%) showed the maximum CI at a much faster 60-105 s. There was a statistically significant difference between SCC and malignant lymphoma in the time needed reach the maximum CI (p = 0.0177). There was also significant difference between SCC and malignant lymphoma in their maximum CIs (p < 0.001), with the maximum CIs of 29/30 SCCs (96.7%) above 2.0, while 12/17 malignant lymphomas (70.6%) showed CIs of less than 2.0. We consider these findings to be useful for distinguishing lymphomas from SCCs.

DOI： 10.1016/j.oraloncology.2003.12.002

Radiographic examination of mesiodens and their associated complications

JI Asaumi, Y Shibata, Y Yanagi, M Hisatomi, H Matsuzaki, H Konouchi, K Kishi

DENTOMAXILLOFACIAL RADIOLOGY 33 ( 2 ) 125 - 127 2004年3月

記述言語：英語出版者・発行元：BRITISH INST RADIOLOGY

Objectives: To examine mesiodens with regard to their status, their influence on adjacent teeth and their alteration during the follow-up period.
Methods: From retrospective reviews of all patients who visited our institution from 1990-2001, we identified 200 patients (256 mesiodentes) who were shown to have mesiodentes on the basis of a periapical radiograph, a panoramic radiograph or an axial radiograph.
Results: The number of supernumerary teeth was one in 146 cases (73%), two in 5 2 cases (26%) and three in 2 cases (1%). Of 256 mesiodentes, the direction of the crown of the mesiodens was inverted in 172 (67%), in a normal direction in 69 (27%) and in a horizontal direction with regard to the tooth axis in 15 (6%). Of the 147 mesiodentes for which axial radiography was performed, 131 (89%) were located at a palatal site against the dental arch, 16 (11%) overlapped the dental arch and none were at a labial site. Of our 200 cases, a delay of eruption of the permanent central incisor was seen in 12 (6%), malposition or rotation of the central incisor in 5 (2.5%) and dentigerous cyst formation arising from mesiodens in 22 (11%). Marked movement of the mesiodens was seen in 10 cases during the follow-up period of 5-7 years. Some complication arising from mesiodens was seen in 19.5% of all cases in our research.
Conclusion: Although mesiodentes are not caused by malocclusion, they may cause it. A long period of impaction of mesiodentes may bring about dentigerous cyst formation or movement of the mesiodentes.

DOI： 10.1259/dmfr/68039278

同時性に発生した Ameloblastoma と Dentigerous Cyst の1例

久富美紀, 浅海淳一, 柳文修, 此内浩信, 岸幹二

日本口腔診断学会雑誌 = Japanese journal of oral diagnosis/oral medicine 17 ( 1 ) 189 - 192 2004年3月

Radiographic examination of dentigerous cysts in the transitional dentition

Y Shibata, J Asaumi, Y Yanagi, N Kawai, M Hisatomi, H Matsuzaki, H Konouchi, H Nagatsuka, K Kishi

DENTOMAXILLOFACIAL RADIOLOGY 33 ( 1 ) 17 - 20 2004年1月

記述言語：英語出版者・発行元：BRITISH INST RADIOLOGY

Objectives: To examine radiographically the relationship between the deciduous tooth and dentigerous cyst of the permanent successor during the transitional dentition.
Methods: From a retrospective review of all patients who visited our institution from April 1988 to August 2001, 70 patients under 16 years of age who had histologically confirmed dentigerous cysts that had developed from the central incisor to the second premolar were identified. These 70 patients were investigated using panoramic and periapical radiographs.
Results: Inmost cases (54 cases; 77.1%) the cyst was in the premolar region. Of the 54 premolars with dentigerous cysts, the overlying deciduous tooth had already been lost in 7 cases. Of the 47 remaining premolars with associated deciduous tooth, 35 (74.5%) had bone resorption of the periapical or bifurcation region, or irregular resorption of the associated deciduous tooth. Of the remaining 12 deciduous teeth with no periapical lesions, 9 had been treated with root canal therapy. Thus, 44 of these 47 cases (93.6%) had the possibility of inflammation at the deciduous tooth associated with the dentigerous cyst. Evidence from one case in the present study suggesting the process by which cyst development occurs is also given.
Conclusion: Inflammatory change at the apex of the deciduous tooth may bring on a dentigerous cyst of the permanent successor.

DOI： 10.1259/dmfr/24148363

Test injection用造影剤による造影効果に関する研究

柳文修, 此内浩信, 久富美紀, 浅海淳一, 岸幹二

日本画像医学雑誌 22 ( 5 ) 54 - 54 2004年1月

MRIを用いた摂食嚥下動態の解析法の開発(2)座位での撮影が可能なMRIの使用経験

本多康聡, 柳文修, 河井紀子, 岸幹二, 江草正彦, 石田僚, 森貴幸, 梶原京子

日本摂食・嚥下リハビリテーション学会雑誌 7 ( 2 ) 187 - 187 2003年12月

The value of dynamic contrast-enhanced MRI in diagnosis of malignant lymphoma of the head and neck. 国際誌

Jun-ichi Asaumi, Yoshinobu Yanagi, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Kanji Kishi

European journal of radiology 48 ( 2 ) 183 - 7 2003年11月

記述言語：英語出版者・発行元：ELSEVIER SCI IRELAND LTD

In this study, we attempted to diagnose malignant lymphoma on the basis of magnetic resonance imagings (MRIs) and dynamic contrast-enhanced MRI (DCE-MRI). Eighteen lesions (in eight patients), all of which had been proven histopathologically, were detected on MRI. The eight patients included five patients with diffuse large B-cell lymphoma, one with B-cell low-grade MALT lymphoma, one with follicular lymphoma, and one with Hodgkin's lymphoma. Nine lesions were located in the submandibular region, three in the buccal region, two in the orbit region, two in the submental region, and one each in the palatal and tonsil regions. The diameter of the lesions ranged between 9 and 42.2 mm (average: 22.4 mm). The signal intensities (SIs) of the 18 lesions were examined on T1-weighted (T1WI), T2WI, and gadopentetate (Gd)-T1WI. One lesion in case 8 was excluded from DCE-MRI findings, i.e., the regions of interest could not be adequately set on DCE-MRIs. The contrast index (CI) curves of the remaining 17 lesions were prepared. All 18 lesions showed almost the same images on T1WI, T2WI, and Gd-T1WI, although they represented four types of lymphoma. The images showed homogeneous SI that was intermediate to slightly high SI on T1WI, slightly high SI on T2WI, and moderately enhanced on Gd-T1WI. Thus, the cases of malignant lymphoma in this study showed relatively characteristic features based on MRI; however, these features might be non-specific. The CI curves in this study showed a relatively rapid increase, reaching a maximum CI at 45-120 s, and a relatively rapid decrease in most lesions (14/17; 82.4%); on the other hand, the curves of 3 of the 15 lesions (17.6%) showed relatively rapid increase, sustenance of a plateau, and a gradual decrease thereafter. These patterns of CI curves may indicate characteristic features useful for distinguishing malignant lymphomas from other lesions.

DOI： 10.1016/S0720-048X(02)00347-9

MR imaging of epithelial cysts of the oral and maxillofacial region. 国際誌

Miki Hisatomi, Jun-ichi Asaumi, Hironobu Konouchi, Hiroshi Shigehara, Yoshinobu Yanagi, Kanji Kishi

European journal of radiology 48 ( 2 ) 178 - 82 2003年11月

記述言語：英語出版者・発行元：ELSEVIER SCI IRELAND LTD

The aim of the present study was to review the magnetic resonance (MR) appearance of primary epithelial cysts in order to distinguish the cysts from other possible lesions. MR images were obtained in 27 cases of epithelial cysts, including 7 odontogenic keratocysts, 3 dentigerous cysts, 1 glandular odontogenic cyst, 10 radicular cysts, 4 nasopalatine duct cysts, and 2 nasolabial cysts. In addition, contrast enhanced MR imagings were performed in 12 cases, including 3 odontogenic keratocysts, 1 dentigerous cyst, 1 glandular odontogenic cyst, and 7 radicular cysts. We obtained the following results on the basis of the above MR and contrast enhanced MR findings. (a) Odontogenic keratocysts had a predilection for intermediate-high signal intensity (SI) on T1-weighted images (WI) and heterogeneous low-high SI on T2WI. (b) Dentigerous cysts, glandular odontogenic cyst, radicular cysts and nasolabial cysts showed the same predilection with the SI, which were homogeneous intermediate SI on T1WI and homogeneous high SI on T2WI. (c) The MR images of the nasopalatine duct cysts, which showed homogeneous high SI on T1WI, were specific. (d) The Gd-T1WI would be useful in decisively differentiating odontogenic cysts, which showed rim-enhancement, from tumors consisting of solid components. In conclusion, we were able to obtain more information from the MR and contrast enhanced MR images than from conventional radiograph findings.

DOI： 10.1016/S0720-048X(02)00218-8

Assessment of pleomorphic adenomas using MRI and dynamic contrast enhanced MRI. 国際誌

Miki Hisatomi, Jun-ichi Asaumi, Yoshinobu Yanagi, Hironobu Konouchi, Hidenobu Matsuzaki, Yasutoshi Honda, Kanji Kishi

Oral oncology 39 ( 6 ) 574 - 9 2003年9月

記述言語：英語出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a). Pleomorphic adenomas showed a predilection for homogeneous intermediate signal intensity on T1-weighted images (T1WI), heterogeneous high signal intensity on T2-weighted images, and heterogeneous enhancement on Gd-T1WI. (b). Of 11 contrast index (CI) curves of pleomorphic adenomas, nine CI curves (81.8%) increased gradually to 600 s or increased gradually, reached a plateau, and sustained the plateau to 600 s. The remaining two (18.2%) increased gradually and decreased gradually thereafter. (c). CI curves reached the maximum CI index at 135-300 s.

DOI： 10.1016/S1368-8375(03)00040-X

頭頸部悪性リンパ腫の画像診断におけるDynamic Contrast-Enhanced MRIの有用性

浅海淳一, 此内浩信, 柳文修, 久富美紀, 松崎秀信, 岸幹二

歯科放射線 43 ( 増刊 ) 35 - 35 2003年9月

口腔顎顔面領域の上皮性嚢胞のMR像

岸幹二, 久富美紀, 此内浩信, 柳文修, 本多康聡, 浅海淳一

歯科放射線 43 ( 増刊 ) 50 - 50 2003年9月

Incidentally found and unexpected tumors discovered by MRI examination for temporomandibular joint arthrosis. 国際誌

Yoshinobu Yanagi, Jun-ichi Asaumi, Yuu Maki, Jun Murakami, Miki Hisatomi, Hidenobu Matsuzaki, Hironobu Konouchi, Yosutoshi Honda, Kanji Kishi

European journal of radiology 47 ( 1 ) 6 - 9 2003年7月

記述言語：英語出版者・発行元：ELSEVIER SCI IRELAND LTD

We examined the frequency of incidentally found or unexpected tumors discovered at the time of magnetic resonance imaging (MRI) examinations in the temporomandibular joint (TMJ) region for patients with suspicion of TMJ arthrosis. Five MR images (T1-weighted transverse scout image and proton density and T2-weighted oblique sagittal images at the open and closed mouth) were acquired. In 2776 MRI examinations of TMJ arthrosis, two tumors were discovered. They consisted of an adenoid cystic carcinoma in the deep portion of the parotid gland, and a malignant tumor extending from the infratemporal fossa to the parapharyngeal space. The rate of incidentally founded or unexpected tumors in TMJ examinations was low (0.072%), but the two tumors found were malignant tumors, and therefore, scout image should be carefully examined, not only used for positing the slice.

DOI： 10.1016/S0720-048X(03)00095-0

顎関節部MRI撮影時における偶発腫

牧優, 柳文修, 浅海淳一, 岸幹二

岡山歯学会雑誌 22 ( 1 ) 242 - 243 2003年6月

Comparison of radiographic and MRI features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots

M Hisatomi, J Asaumi, H Konouchi, Y Yanagi, H Matsuzaki, K Kishi

ORAL DISEASES 9 ( 3 ) 152 - 157 2003年5月

記述言語：英語出版者・発行元：BLACKWELL MUNKSGAARD

Lesions that can produce divergence of the roots of teeth in the mandible include odontogenic cysts (odontogenic keratocysts, lateral periodontal cysts and radicular cysts), ameloblastomas, odontogenic myxomas, central giant cell granulomas, adenomatoid odontogenic tumors and aneurismal bone cysts, and other tumors. Moreover most benign jaw lesions can do this occasionally. However, when lesions - which show interradicular tear-shaped radiolucencies - are small it is often difficult to interpret them radiographically, because they do not show characteristic radiographic features. We describe a comparison of radiographic and magnetic resonance (MR) features of a root-diverging odontogenic myxoma, with discussion of the differential diagnosis of lesions likely to move roots. In addition, we discuss radiographic and MR features of possible lesions, which show similar radiographic findings to odontogenic myxoma.

DOI： 10.1034/j.1601-0825.2003.01802.x

Evaluation of tumor proliferation using dynamic contrast enhanced-MRI of oral cavity and oropharyngeal squamous cell carcinoma

H Konouchi, J Asaumi, Y Yanagi, H Shigehara, M Hisatomi, H Matsuzaki, K Kishi

ORAL ONCOLOGY 39 ( 3 ) 290 - 295 2003年4月

記述言語：英語出版者・発行元：PERGAMON-ELSEVIER SCIENCE LTD

We investigated the relationship between the enhanced patterns acquired by dynamic MRI and the tumor cell proliferation estimated by immunostaining proliferating cell nuclear antigen (PCNA) in oral squamous cell carcinoma (SCC). Thirty patients with primary oral SCC underwent dynamic contrast enhanced (DCE)-MRI using a three-dimensional fast imaging with steady-state precession sequence. Tumor cell proliferation of all surgical specimens was evaluated using immunohistochernical staining with the anti-PCNA antibody. The relationship between the dynamic MR1 parameters (maximum CI and maximum CI gain) and the PCNA labeling index was statistically analyzed using regression analysis. The time contrast index curves of all cases showed a rapid and high uptake pattern. The PCNA labeling index showed a significant correlation with tnaxitnutn CI and maximum CI gain (P<0.0001, r=0.866 and P=0.0019, r=0.544, respectively). The assessment of DCE-MRI parameters may provide valuable information for tumor cell proliferation of the patients with oral cancer. (C) 2003 Elsevier Science Ltd. All rights reserved.

DOI： 10.1016/S1368-8375(02)00119-7

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Thermoradiotherapy combined with adenoviral p53 gene therapy in head and neck squamous cell carcinoma cell lines

Y Higuchi, J Asaumi, J Murakami, H Matsuzaki, T Wakasa, T Inoue, H Konoucni, M Hisatomi, Y Yanagi, Y Honda, H Shigehara, K Kishi

ONCOLOGY REPORTS 10 ( 2 ) 415 - 420 2003年3月

記述言語：英語出版者・発行元：PROFESSOR D A SPANDIDOS

We examined effects of recombinant p53-expressing adenovirus combined with thermoradiotherapy in 8 head and neck squamous cell carcinoma (SCC) cell lines to improve the outcomes of the threatment of advanced head and neck cancer. The p53 gene therapy did not improve the discrepancy between thermoradiosensitivities among the 8 SCC cell lines. However, p53 gene therapy improved the effects of thermoradiotherapy in all 8 cell lines, and there were significant differences in four situations of the HSC4 44degreesC (p=0.032), SAS at 44degreesC (p=0.029), the KB at 43degreesC (p=0.025), and the Ca9-22 43degreesC (p=0.020). In comparing the survival rates of thermoradiotherapy with those of thermotherapy and radiotherapy, thermoradiotherapy demonstrated actual survival rates less than theoretical survival rates based on the survival rates of thermotherapy multiplied by the survival rates of radiotherapy in almost all treatments of thermoradio-gene therapy of the 8 SCC cell lines. These results demonstrate that thermoradiotherapy combined with p53 gene therapy may be a useful tool in treating SCC cells.

DOI： 10.3892/or.10.2.415

顎関節部MRI撮影時における偶発腫

牧優, 柳文修, 浅海淳一, 岸幹二

歯科放射線 43 ( 1 ) 32 - 32 2003年3月

頬部血管平滑筋腫の一例

柳文修, 浅海淳一, 此内治信, 岸幹二

歯科放射線 43 ( 1 ) 30 - 30 2003年3月

頭頸部悪性リンパ腫の診断におけるdynamic contrast-enhanced MRIの有用性

此内浩信, 浅海淳一, 柳文修, 岸幹二

日本画像医学雑誌 21 ( 5 ) 213 - 213 2003年2月

Usefulness of dynamic contrast-enhanced MRI in the differential diagnosis of angioleiomyoma in the buccal space

Yoshinobu Yanagi, Jun-Ichi Asaumi, Miki Hisatomi, Hidenobu Matsuzaki, Yosutoshi Honda, Hironobu Konouchi, Kanji Kishi

European Journal of Radiology Extra 48 ( 1 ) 14 - 18 2003年

記述言語：英語出版者・発行元：Elsevier BV

We describe a case of angioleiomyoma in the buccal space, and discuss its magnetic resonance imaging (MRI) features with histopathological correlation, with particular emphasis on the usefulness of using dynamic contrast-enhanced MRI (DCE-MRI) to differentiate other possible tumors. Angioleiomyoma of the buccal space in this case corresponded clinically and histopathologically to the previous reports. The characteristic findings of angioleiomyoma were a very high signal intensity on T2WI, and extremely high enhancement on Gd-T1WI. The inner aspect of this lesion was homogeneous on both T1WI and T2WI. However, the histopathological findings included tumor substance, mucous degeneration, and mature adipose cells, and these findings were reflected only on the DCE-MRI. Furthermore, the CI-Curve of the angioleiomyoma showed a characteristic pattern, which might differentiate it from other tumors. © 2003 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/S1571-4675(03)00080-4

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