Faculty Profiles - NAKATSUKA Mikiya

Papers - NAKATSUKA Mikiya

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性的マイノリティ当事者を取り巻く現状-法律，結婚，生殖医療など

中塚幹也

医学のあゆみ 279 ( 4 ) 288 - 292 2021.10

Inflammation of the adipose tissue in the retroperitoneal cavity adjacent to pelvic endometriosis International journal

Kotaro Kubo, Yasuhiko Kamada, Toru Hasegawa, Ai Sakamoto, Mikiya Nakatsuka, Takashi Matsumoto, Hisashi Masuyama

THE JOURNAL OF Obstetrics and Gynaecology Reserch 47 ( 10 ) 3598 - 3606 2021.10

Language：English Publishing type：Research paper (scientific journal)

AIM: Peritoneal endometriosis is a chronic inflammatory disease particularly associated with macrophages. Of note, adipose tissues with fibrotic changes in the context of peritoneal endometriotic lesions are often observed during surgery. However, the characteristics of fibrotic adipose tissues in endometriosis are still unknown. In this study, we investigated the inflammatory status of retroperitoneal adipose tissues adjacent to pelvic endometriotic lesions. METHODS: Thirty-two patients who underwent surgical treatment were assigned to either the endometriosis (n = 16) or the control (n = 16) groups. Retroperitoneal adipose tissues around the uterus were collected from patients in both groups. Fibrosis was evaluated via Masson's trichrome staining. Macrophage infiltration, the expression of fatty acid-binding protein 4 (FABP4), and angiogenesis in the retroperitoneal adipose tissues were evaluated via immunohistochemistry. The mRNA expression levels of cytokines was also evaluated in the adipose tissues using real-time PCR. RESULTS: There was more fibrosis and angiogenesis in the adipose tissues adjacent to the endometriotic lesions with a significantly higher level of infiltration of macrophages and a predominance of the M1 type in the endometriosis group compared to the control group. In addition, FABP4 positivity in the adipose tissues of the peritoneum was significantly higher in the endometriosis group versus the control group. Moreover, the mRNA expression levels of FABP4, VEGF, and proinflammatory cytokines were also significantly higher in the endometriosis group. CONCLUSION: Altogether, our results showed that the adipose tissue adjacent to endometriotic lesions are inflamed with fibrosis and angiogenesis.

DOI： 10.1111/jog.14958

PubMed

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連載LGBT第２回：トランスジェンダーにおける身体的治療

中塚幹也

性の健康 20 ( 3 ) 27 - 29 2021.9

Relation Between Identity Disclosure to Family Members and Mental Health in Japan Transgender People

Yu Zhou, Michiyo Furutani, Rukumali Athurupana, Mikiya nakatsuka

Acta Medica Okayama 75 ( 6 ) 611 - 623 2021.5

The Thickness and Density of the Ovarian Tunica Albuginea Increases with Age in Transgender Patients

Pilar Ferré-Pujol, Junko Otsuki, Hiroaki Funahashi, Mikiya Nakatsuka

Reproductive Sciences 2021.1

Gender Expression among Transgender Women in Japan: Support Is Needed to Improve Social Passing as a Woman

Michiyo Furutania, Zhou Yua, Mikiya Nakatsuka

Acta Medica Okayama 75 ( 3 ) 323 - 334 2021

LGBT当事者への生殖医療の実態と意識産婦人科施設代表者への全国調査から

樫野千明, 細木菜々恵, 周宇, 中塚幹也

GID(性同一性障害)学会雑誌 13 ( 1 ) 15 - 29 2020.12

自治体職員の職場におけるLGBT(性的マイノリティ)当事者への意識と対応

周宇, 松本梓, 樫野千明, 中塚幹也

GID(性同一性障害)学会雑誌 13 ( 1 ) 43 - 53 2020.12

大学におけるLGBT当事者支援に対する大学生の意識とカミングアウトされた時の気持ちや行動

周宇, 安間友美, 樫野千明, 中塚幹也

GID(性同一性障害)学会雑誌 13 ( 1 ) 75 - 88 2020.12

The beta(2)-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome

Kenji Tanimura, Shigeru Saito, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Atsushi Fukui, Masashi Deguchi, Yuki Sasagawa, Noriko Arase, Hisashi Arase, Hideto Yamada

ARTHRITIS & RHEUMATOLOGY 72 ( 11 ) 1882 - 1891 2020.11

着床前診断・スクリーニングを受けるか否かの意思決定を女性が行う際の要因に関する文献検討

美甘祥子, 井田歩美, 片岡久美恵, 中塚幹也

母性衛生 61 ( 3 ) 143 - 143 2020.9

産褥精神病，マタニティブルース Reviewed

Mikiya Nakatsuka

50 ( 8 ) 1417 - 1418 2020.8

高校生におけるSNSの中でのデートDV

日本性科学会雑誌 38 ( 1 ) 31 - 42 2020.7

連載第36回：不育症の基礎知識と患者支援のポイント「周囲のありがちな対応と不育症女性の心理」 Reviewed

Mikiya Nakatsuka

12 ( 4 ) 76 - 79 2020.7

当院の不育症患者に対するステロイド治療の検討

久保光太郎, 鎌田泰彦, 樫野千明, 中塚幹也, 増山寿

現代産婦人科 68 ( 2 ) 201 - 205 2020.6

2-5 不妊治療施設の看護スタッフにおける「男性不妊Jべの対応の実態と意識

20200400 60 - 61 2020.4

2-4 大学生の不妊に関する意識の実態調査

20200400 58 - 89 2020.4

1-8不育症ピアの会「ママとたまごの会」における交流会の活動報告と今後の課題

20200400 43 - 44 2020.4

Increased Plasma Levels of Platelet Factor 4 and β-thromboglobulin in Women with Recurrent Pregnancy Loss.

Sayoko Kotani, Yasuhiko Kamada, Keiko Shimizu, Ai Sakamoto, Mikiya Nakatsuka, Yuji Hiramatsu, Hisashi Masuyama

Acta medica Okayama 74 ( 2 ) 115 - 122 2020.4

Language：English Publishing type：Research paper (scientific journal)

Thrombosis in decidual vessels is one of the mechanisms of pregnancy loss. However, few studies have assessed the relation between platelet activation, which is known to cause of thrombosis, and recurrent pregnancy loss (RPL). We investigated platelet activation in women with RPL compared to controls by measuring plasma levels of platelet factor 4 (PF4) and β-thromboglobulin (βTG), and assessed correlations between PF4/βTG and coagulative risk factors associated with RPL. The study group included 135 women who had experienced two or more consecutive pregnancy losses. The control group included 28 age-matched healthy women who had never experienced pregnancy loss. PF4 and βTG plasma levels were significantly higher in the women with RPL than controls (PF4: 14.0 [8.0-20.0] vs. 9.0 [6.0-12.0] ng/ml, p=0.043; βTG: 42.0 [24.3-59.8] vs. 31.5 [26.6-36.4] ng/ml, p=0.002). There was a significant association between βTG and anti-phosphatidylethanolamine antibody immunoglobulin M (aPE IgM) (p=0.048). Among the women with RPL, 18 of those who were positive for PF4 (45%) and 18 of those who were positive for βTG (37%) were negative for all known coagulative risk factors associated with RPL. Measurements of PF4 and βTG may be important because they help identify women who are at risk of RPL.

DOI： 10.18926/AMO/58269

PubMed

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特別報告：多様化する健康課題?性別違和感を持つ子供たち? 「研究者の立場から」 Reviewed

Mikiya Nakatsuka

15 ( 1 ) 7 - 10 2020.3

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