研究者詳細 - 窪木　拓男

MISC - 窪木　拓男

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インプラント義歯装着患者のQOLレベル測定におけるレスポンスシフトの影響

荒川光, 木村彩, 野田欣志, 完山学, 窪木拓男

日本口腔インプラント学会誌 20 ( 1 ) 2007年

金属アレルギー患者に対するインプラント治療-チタン製修復物による暴露試験でチタンの安全性を確認した一症例-

完山学, 真野隆充, 荒川光, 峯篤史, 上山吉哉, 窪木拓男

日本口腔インプラント学会誌 20 ( 1 ) 2007年

Regression of pustulosis palmaris et plantaris by periodontal treatment in a subject with severe periodontitis. 国際誌

Hiroshi Akazawa, Fushanori Nishimura, Hiroshi Maeda, Shogo Takashiba, Atsushi Mine, Kenji Maekawa, Takuo Kuboki

International journal of dermatology 45 ( 12 ) 1420 - 2 2006年12月

記述言語：英語出版者・発行元：BLACKWELL PUBLISHING

A 38-year-old woman with pustulosis palmaris et plantaris (PPP) was referred to the dentist with a suspicion of metal allergy (Fig. 1A). She had noticed the symptoms 3 years previously on her palms and legs. As her symptoms did not improve spontaneously, she visited her dermatologist. There, she was recorded as follows: (1) pustules localized only on the palms and soles; (2) no lesions with eczema or psoriasis on any other parts of the body; and (3) no family history of pustulosis. On the basis of these observations, she was diagnosed with PPP. She was treated with topical application of corticosteroids; however, her symptoms did not improve. Her dermatologist then suspected metal allergy and performed a patch test. Her skin reacted positively with chromium sulfate, zinc chloride, and mercury bichloride. Therefore, she was referred to our dental hospital for the investigation of the possible association of PPP with oral restorative materials.
Her medical records were unremarkable, except for extremely severe periodontitis, which she was aware of more than 10 years previously; however, she had not received any comprehensive periodontal treatment. On presentation, we first analyzed the restorative materials of the teeth to determine whether they contained any positive elements detected by the patch test. Unfortunately, we could not detect any positive elements in the oral cavity. Her blood chemistry did not indicate any abnormalities. The white blood cell count was 5600/mm(3), with differential counts of 49.3% neutrophils, 28.0% lymphocytes, 7.6% monocytes, 14.4% eosinophils, and 0.7% basophils. C-reactive protein was not elevated, as measured by the conventional method. Immunoglobulin G (IgG), IgA, and IgM concentrations were all within the normal range (IgG, 1243.0 mg/dL; IgA, 131.6 mg/dL; IgM, 149.6 mg/dL). Because of these laboratory data, we first treated her periodontitis to determine whether there was a possible relationship of her PPP to severe periodontitis.
Her periodontitis was very severe (Fig. 2A,B). The extraction of several teeth, as well as the correction of the shape of the inflamed alveolar bone (the bone supporting the teeth) to a physiological shape, was necessary. We first treated her periodontitis with the topical application of antibiotics (minocycline-HCl ointment) to determine the effect of anti-infectious periodontal treatment on PPP. We administered the antibiotics in every periodontal pocket once a week for a period of 1 month. One month after treatment, her symptoms appeared to improve slightly (Fig. 1B). We next performed surgical treatment, including teeth extractions and correction of the bone shape. Two to three days after surgery, her PPP symptoms worsened suddenly (Fig. 1C), and continued for up to 1 month (Fig. 1D). From 1 month after surgery, however, her symptoms gradually improved and complete remission was observed (Fig. 1E). In addition, although more than 2 years have passed since complete remission, no recurrence has been observed (Fig. 1F).

DOI： 10.1111/j.1365-4632.2006.02900.x

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臨床エビデンスに基づく顎関節症の診断と治療口腔顔面痛や口腔運動器疾患を治療する立場から

窪木拓男

日本顎頭蓋機能学会誌 19 ( 1 ) 55 - 55 2006年12月

簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果

水口一, 永松千代美, 前川賢治, 完山学, 松香芳三, 窪木拓男

日本顎頭蓋機能学会誌 19 ( 1 ) 46 - 46 2006年12月

【Orofacial Pain 歯科はどうかかわるか】咬合感覚異常の鑑別診断

窪木拓男

歯界展望 108 ( 5 ) 1019 - 1025 2006年11月

チタン表面と生体分子の相互作用解析のためのバイオセンサーの開発

平田伊佐雄, 岡崎正之, 吉田靖弘, 鈴木一臣, 前川賢治, 窪木拓男

日本口腔インプラント学会誌 19 ( 3 ) 325 - 325 2006年9月

ラット1次求心ニューロンに対するIsolectin B4とsaporinの複合体(IB4-sap)の毒性

福田朋樹, 寺山隆司, 市川博之, 窪木拓男, 杉本朋貞

Journal of Oral Biosciences 48 ( Suppl. ) 171 - 171 2006年9月

簡易貼付型睡眠時ブラキシズム測定装置のバージョンアップとその効果

水口一, 永松千代美, 前川賢治, 完山学, 松香芳三, 窪木拓男, Clark Glenn T.

日本補綴歯科学会雑誌 50 ( 115回特別 ) 153 - 153 2006年7月

硬組織再生研究の最前線歯科治療における再生医療のニーズと現時点での研究動向確実かつ質の高いインプラント治療をめざして

窪木拓男

日本骨代謝学会学術集会プログラム抄録集 24回 76 - 76 2006年7月

結合組織成長因子CCN2/CTGFによる骨髄由来間質細胞の細胞接着、遊走の亢進とシグナル伝達経路の活性化

大野充昭, 藤澤拓生, 久保田聡, 園山亘, 秋山謙太郎, 西田崇, 滝川正春, 窪木拓男

日本骨代謝学会学術集会プログラム抄録集 24回 248 - 248 2006年7月

根未完成永久歯における新規間葉系幹細胞の同定

園山亘, 窪木拓男, Shi S

日本補綴歯科学会雑誌 50 ( 115回特別 ) 172 - 172 2006年7月

クリニカルパスと症型分類(その2) 補綴歯科治療の難易度を決定する補綴歯科治療の難易度を測定するプロトコルの信頼性と妥当性の検討エビデンスに基づく補綴医療をめざして

窪木拓男

日本補綴歯科学会雑誌 50 ( 115回特別 ) 68 - 68 2006年7月

ポリリン酸処理によるチタンインプラントの細胞応答促進と成長因子吸着制御

前川賢治, 吉田靖弘, 峯篤史, 大島正充, 下野賢吾, 秋山謙太郎, 藤澤拓生, 鈴木一臣, 窪木拓男

日本補綴歯科学会雑誌 50 ( 115回特別 ) 91 - 91 2006年7月

貼付型ブラキシズム測定装置により計測したブラキシズム頻度と頭頸背部の筋痛の関連性

永松千代美, 水口一, 前川賢治, 完山学, 松香芳三, 窪木拓男, Clark Glenn T.

日本補綴歯科学会雑誌 50 ( 115回特別 ) 152 - 152 2006年7月

Spectroscopic characterization of enamel surfaces irradiated with Er:YAG laser.

Atsushi Mine, Yasuhiro Yoshida, Kazuomi Suzuki, Youichi Nakayama, Hirofumi Yatani, Takuo Kuboki

Dental materials journal 25 ( 2 ) 214 - 8 2006年6月

記述言語：英語出版者・発行元：JAPANESE SOC DENTAL MATERIALS DEVICES

The purpose of this study was to investigate the effect of laser irradiation on the enamel surface spectroscopically. Polished bovine enamel surface was irradiated with an Er:YAG laser apparatus and chemically analyzed using X-ray photoelectron spectroscopy (XPS). XPS detected core electron peaks such as carbon (C 1s) and nitrogen (N 1s), as well as calcium (Ca 2s, Ca 2p, Ca 3s, Ca 3p), phosphorous (P 2s, P 2p), and oxygen (O 1s), from the control enamel surface. After irradiation, XPS revealed that the intensity of C 1s peak slightly decreased while that of N 1s diminished below the detection limit. Detailed C 1s narrow scan spectrum of the Er:YAG laser-irradiated enamel surface showed that C-O/C-N, C = O/-CON=, -COO-, and CO,3(2-) components, attributed to the specific composition of enamel and any common carbon contamination in surplus, relatively decreased. The binding energies of Ca 2p and P 2p, delta (Ca 2p, P 2p), and the Ca/P ratio of lased enamel were found to be different from those of non-lased enamel. It was also shown that Er:YAG laser ablation caused surface alterations to the apatitic inorganic components of tooth tissue.

DOI： 10.4012/dmj.25.214

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顎関節MRIを用いた関節円板動態診断の変動と信頼性

永松千代美, 小野剛, 前川賢治, 柳文修, 浅海淳一, 荒木佳子, 片山朗, 谷本裕子, 宮脇正一, 山本照子, 岸幹二, 窪木拓男

日本顎関節学会雑誌 18 ( 1 ) 60 - 60 2006年4月

ASIC3-immunoreactive neurons in the rat vagal and glossopharyngeal sensory ganglia

T Fukuda, H Ichikawa, R Terayama, T Yamaai, T Kuboki, T Sugimoto

BRAIN RESEARCH 1081 150 - 155 2006年4月

記述言語：英語出版者・発行元：ELSEVIER SCIENCE BV

ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immuno fluorescence method demonstrated that many ASIC3-immunoreactive (ir) neurons co-expressed calcitonin gene-related peptide (CGRP)- or vanilloid receptor subtype 1 (VRL-1)-ir in the jugular (CGRP, 77.8%; VRL-1, 28.0%) and petrosal ganglia (CGRP, 61.7%; VRL-1, 21.5%). In the nodose ganglion, however, such neurons were relatively rare (CGRP, 6.3%; VRL-1, 0.4%). ASIC3-ir neurons were mostly devoid of tyrosine hydroxylase in these ganglia. However, some ASIC3-ir neurons co-expressed calbindin D28k in the petrosal (5.5%) and nodose ganglia (3.8%). These findings may suggest that ASIC3-containing neurons have a wide variety of sensory modalities in the vagal and glossopharyngeal sensory ganglia. (c) 2006 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.brainres.2006.01.039

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Er:YAGレーザー照射象牙質に対する光硬化型グラスアイオノマーの接着レーザーを用いたう蝕処置におけるゼロステップ修復の検討

峯篤史, 鈴木一臣, 窪木拓男

日本レーザー歯学会誌 17 ( 1 ) 37 - 37 2006年4月

チタンへの接着性に及ぼすリン酸エステル系モノマーの影響

吉田靖弘, 土本洋平, 泓川大輔, 峯篤史, 窪木拓男, 鈴木一臣

歯科材料・器械 25 ( 2 ) 143 - 143 2006年4月

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