Faculty Profiles - KUBOKI Takuo

Papers - KUBOKI Takuo

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A novel brief questionnaire using a face rating scale to assess dental anxiety and fear Reviewed

Takuya Mino, Aya Kimura-Ono, Hikaru Arakawa, Kana Tokumoto, Yoko Kurosaki, Yoshizo Matsuka, Kenji Maekawa, Takuo Kuboki

The Journal of Advanced Prosthodontics 16 ( 4 ) 244 - 244 2024

Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors Reviewed International journal

Loc Dinh Hoang, Eriko Aoyama, Miki Hiasa, Hiroshi Omote, Satoshi Kubota, Takuo Kuboki, Masaharu Takigawa

International Journal of Molecular Sciences 24 ( 24 ) 17294 - 17294 2023.12

Language：English Publishing type：Research paper (scientific journal) Publisher：MDPI AG

S-adenosylmethionine (SAM) is considered to be a useful therapeutic agent for degenerative cartilage diseases, although its mechanism is not clear. We previously found that polyamines stimulate the expression of differentiated phenotype of chondrocytes. We also found that the cellular communication network factor 2 (CCN2) played a huge role in the proliferation and differentiation of chondrocytes. Therefore, we hypothesized that polyamines and CCN2 could be involved in the chondroprotective action of SAM. In this study, we initially found that exogenous SAM enhanced proteoglycan production but not cell proliferation in human chondrocyte-like cell line-2/8 (HCS-2/8) cells. Moreover, SAM enhanced gene expression of cartilage-specific matrix (aggrecan and type II collagen), Sry-Box transcription factor 9 (SOX9), CCN2, and chondroitin sulfate biosynthetic enzymes. The blockade of the methionine adenosyltransferase 2A (MAT2A) enzyme catalyzing intracellular SAM biosynthesis restrained the effect of SAM on chondrocytes. The polyamine level in chondrocytes was higher in SAM-treated culture than control culture. Additionally, Alcian blue staining and RT-qPCR indicated that the effects of SAM on the production and gene expression of aggrecan were reduced by the inhibition of polyamine synthesis. These results suggest that the stimulation of polyamine synthesis and gene expression of chondrogenic differentiation factors, such as CCN2, account for the mechanism underlying the action of SAM on chondrocytes.

DOI： 10.3390/ijms242417294

PubMed

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可撤性上部構造へ置換後のパーキンソン病患者にインプラントに起因するトラブルが生じた介護現場での1例

徳本佳奈, 三野卓哉, 高岡一樹, 前川賢治, 窪木拓男, 岸本裕充

日本口腔リハビリテーション学会雑誌 36 ( 1 ) 67 - 67 2023.12

可撤性上部構造へ置換後のパーキンソン病患者にインプラントに起因するトラブルが生じた介護現場での1例

徳本佳奈, 三野卓哉, 高岡一樹, 前川賢治, 窪木拓男, 岸本裕充

日本口腔リハビリテーション学会雑誌 36 ( 1 ) 67 - 67 2023.12

Accuracy of a novel modified single computed tomography scanning method for assisting dental implant placement: a retrospective observational study. Reviewed International journal

Hiroaki Shimizu, Takuya Mino, Yoko Kurosaki, Hikaru Arakawa, Kana Tokumoto, Aya Kimura-Ono, Kenji Maekawa, Takuo Kuboki

International journal of implant dentistry 9 ( 1 ) 42 - 42 2023.11

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: The aim of this study is to compare dental implant placement accuracy of three surgical guide fabrication methods: single (SCT) and double computed tomography (DCT), and a newly developed modified SCT (MSCT) scan method. METHODS: A total of 183 cases (183 surgical guides, and 485 implants) of static-guide-assisted implant placement surgery using the SCT, DCT, or MSCT methods in a dental clinic were included in the study. Three-dimensional (3D) deviations (mm) at the entry and tip of the implant body between preoperative simulation and actual placement were measured as surrogate endpoints of implant placement accuracy. The following survey details were collected from medical records and CT data: sex, age at implant placement surgery, surgical guide fabrication method, number of remaining teeth, implant length, implant location, alveolar bone quality, and bone surface inclination at implant placement site in preoperative simulation, etc. Risk factors for reducing implant placement accuracy were investigated using generalized estimating equations. RESULTS: The SCT and DCT methods (odds ratios [ORs] vs. MSCT method: 1.438, 1.178, respectively), posterior location (OR: 1.114), bone surface buccolingual inclination (OR: 0.997), and age at implant placement surgery (OR: 0.995) were significant risk factors for larger 3D deviation at the entry; the SCT (OR: 1.361) and DCT methods (OR: 1.418), posterior location (OR: 1.190), implant length (OR: 1.051), and age at implant placement surgery (OR: 0.995) were significant risk factors for larger 3D deviation at the tip of the implant body. CONCLUSIONS: Implant placement accuracy was better using the MSCT method compared to the SCT and DCT methods.

DOI： 10.1186/s40729-023-00509-8

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パーキンソン病患者の固定性インプラント補綴を可撤性へ置換したが介護現場でのインプラントに起因するトラブルを回避できなかった1例

徳本佳奈, 三野卓哉, 土佐郁恵, 高岡一樹, 前川賢治, 窪木拓男, 岸本裕充

日本口腔インプラント学会誌 36 ( 特別号 ) P - 44 2023.9

暫間上部構造形状を最終上部構造へ反映させるTooth Morphology Fusion Techniqueの有効性に関する介入研究

三野卓哉, 黒崎陽子, 徳本佳奈, 和泉幸治, 仲野友人, 大野彩, 窪木拓男, 前川賢治

日本口腔インプラント学会誌 36 ( 特別号 ) O - 8 2023.9

暫間上部構造形状を最終上部構造へ反映させるTooth Morphology Fusion Techniqueの有効性に関する介入研究

三野卓哉, 黒崎陽子, 徳本佳奈, 和泉幸治, 仲野友人, 大野彩, 窪木拓男, 前川賢治

日本口腔インプラント学会誌 36 ( 特別号 ) O - 8 2023.9

パーキンソン病患者の固定性インプラント補綴を可撤性へ置換したが介護現場でのインプラントに起因するトラブルを回避できなかった1例

徳本佳奈, 三野卓哉, 土佐郁恵, 高岡一樹, 前川賢治, 窪木拓男, 岸本裕充

日本口腔インプラント学会誌 36 ( 特別号 ) P - 44 2023.9

開口障害を有するがんサバイバーのための加工した歯ブラシの歯垢除去効果に関する検討 Reviewed

藤代万由, 松崎久美子, 佐々木禎子, 梶谷明子, 吉田陽子, 宮崎文伸, 三浦留美, 窪木拓男

日本歯科衛生学会雑誌 18 ( 1 ) 153 - 153 2023.8

認知機能と口腔機能の相関に関する探索的研究(ECCO)プロジェクト活動の趣旨と内容 Reviewed

笛木賢治, 佐々木啓一, 眞鍋雄太, 大本克彦, 窪木拓男, 上田貴之, 安部友佳, 稲用友佳, 釘宮嘉浩, 白石成, 齋藤壮, 小林琢也, 橋本衛, 石川智久, 内海久美子, 池田学, 馬場一美, 公益社団法人日本補綴歯科学会研究企画推進委員会

日本補綴歯科学会誌 15 ( 1 ) 72 - 78 2023.1

Language：Japanese Publisher：(公社)日本補綴歯科学会

超高齢社会の本邦において認知症への対策は喫緊の課題であり,国の認知症施策推進総合戦略(新オレンジプラン)において歯科医師にも積極的な関与が求められている.歯学研究において,認知機能と口腔機能の関連は,関心が高いテーマで,これまでに基礎・臨床研究が多数報告されている.その一方,医科専門分野では口腔因子が認知機能の低下または認知症の発症のリスク因子として共有されるに至っていない.(公社)日本補綴歯科学会は,認知機能と口腔機能との相関について新たな研究を展開するために,(公社)日本老年精神医学会と連携して研究プロジェクトを推進している.本稿では,ECCOプロジェクトを設立した経緯と活動内容を概説する.(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J05334&link_issn=&doc_id=20230127240010&doc_link_id=%2Fdv5proso%2F2023%2F001501%2F012%2F0072-0078%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdv5proso%2F2023%2F001501%2F012%2F0072-0078%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Medical-Dental collaboration: Exploratory research project on the Correlation between Cognitive and Oral function (ECCO): background and research activity Reviewed

Kenji Fueki, Keiichi Sasaki, Yuta Manabe, Katsuhiko Kimoto, Takuo Kuboki, Takayuki Ueda, Yuka Abe, Yuka Inamochi, Yoshihiro Kugimiya, Naru Shiraishi, Takashi Saito, Takuya Kobayashi, Mamoru Hashimoto, Tomohisa Ishikawa, Kumiko Utsumi, Manabu Ikeda, Kazuyoshi Baba

Annals of Japan Prosthodontic Society 15 ( 1 ) 72 - 78 2023

Dilemma of cohort study-A concept of early disease markers for measured risk factors. Invited Reviewed

Takuo Kuboki

Journal of prosthodontic research 67 ( 4 ) vi 2023

コロナ禍における老人介護施設での口腔栄養関連サービスに関するPBL演習 Reviewed

前田あずさ,縄稚久美子,菊谷武,兒玉直紀,萬田陽介,窪木拓男

岡山歯学会雑誌 41 ( 2 ) 21 - 33 2022.12

Impact of number of functional teeth on independence of Japanese older adults. Reviewed

Kenji Maekawa, Tomoko Ikeuchi, Shoji Shinkai, Hirohiko Hirano, Masahiro Ryu, Katsushi Tamaki, Hirofumi Yatani, Takuo Kuboki, Aya Kimura-Ono, Takeshi Kikutani, Takashi Suganuma, Yasunori Ayukawa, Tomoya Gonda, Toru Ogawa, Masanori Fujisawa, Shoichi Ishigaki, Yutaka Watanabe, Akihiko Kitamura, Yu Taniguchi, Yoshinori Fujiwara, Ayako Edahiro, Yuki Ohara, Junichi Furuya, Junko Nakajima, Kento Umeki, Kentaro Igarashi, Yasuhiro Horibe, Yoshihiro Kugimiya, Yasuhiko Kawai, Hideo Matsumura, Tetsuo Ichikawa, Shuji Ohkawa, Kazuyoshi Baba

Geriatrics & gerontology international 22 ( 12 ) 1032 - 1039 2022.12

Language：English Publishing type：Research paper (scientific journal)

AIM: To examine the relationship between the number of present and functional teeth at baseline and future incidence of loss of independence. METHODS: Participants were community-dwelling older individuals who participated in a comprehensive geriatric health examination conducted in Kusatsu town, Japan, between 2009 and 2015. The primary endpoint was the incidence of loss of independence among participants, defined as the first certification of long-term care insurance in Japan. The numbers of present and functional teeth at baseline were determined via an oral examination. Demographics, clinical variables (e.g., history of chronic diseases and psychosocial factors), blood nutritional markers, physical functions, and perceived masticatory function were assessed. RESULTS: This study included 1121 individuals, and 205 individuals suffered from loss of independence during the follow-up period. Kaplan-Meier estimates of loss of independence for participants with smaller numbers of present and functional teeth were significantly greater than for those with larger numbers of teeth. Cox proportional hazard analyses indicated that a smaller number of present teeth was not a significant risk factor after adjusting for demographic characteristics. However, the number of functional teeth was a significant risk factor after the adjustment (hazard ratio: 1.975 [1.168-3.340]). Additionally, higher hazard ratios were observed in other adjusted models, but they were not statistically significant. CONCLUSIONS: The number of functional teeth may be more closely related to the future incidence of loss of independence than the number of present teeth. This novel finding suggests that prosthodontic rehabilitation for tooth loss possibly prevents the future incidence of this life-event. Geriatr Gerontol Int 2022; ••: ••-••.

DOI： 10.1111/ggi.14508

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欠損補綴治療が高齢者の食品摂取の多様性や摂取可能食品に与える影響 Reviewed

坂本和基, 大野彩, 三野卓哉, 黒崎陽子, 下村侑司, 大森江, 樋口隆晴, 小山絵理, 徳本佳奈, 縄稚久美子, 窪木拓男

日本口腔リハビリテーション学会雑誌 35 ( 1 ) 79 - 80 2022.12

欠損補綴治療が高齢者の食品摂取の多様性や摂取可能食品に与える影響

坂本和基, 大野彩, 三野卓哉, 黒崎陽子, 下村侑司, 大森江, 樋口隆晴, 小山絵理, 徳本佳奈, 縄稚久美子, 窪木拓男

日本口腔リハビリテーション学会雑誌 35 ( 1 ) 79 - 80 2022.12

卒前臨床技術教育でデジタル光学印象を経験させる相互実習の導入

下村侑司, 土山雄司, 窪木慎野介, 松永直也, 北川若奈, 黄野頂策, 石橋啓, 田仲由希恵, 大森江, 水口真実, 中川晋輔, 三木春奈, 三野卓哉, 前田あずさ, 縄稚久美子, 秋山謙太郎, 水口一, 窪木拓男

岡山歯学会雑誌 41 ( 2 ) 58 - 59 2022.12

Therapeutic effects of peptide P140 in a mouse periodontitis model. Reviewed International journal

Kentaro Akiyama, Kyaw Thu Aung, Laura Talamini, Olivier Huck, Takuo Kuboki, Sylviane Muller

Cellular and molecular life sciences : CMLS 79 ( 10 ) 518 - 518 2022.9

Language：English Publishing type：Research paper (scientific journal)

In our search for innovative drugs that could improve periodontal treatment outcomes, autophagy and its anomalies represent a potential target for therapeutic intervention. We sought to identify autophagy defects in murine experimental periodontitis and study the effectiveness of P140, a phosphopeptide known to bind HSPA8 and inhibit its chaperone properties, and that corrects autophagy dysfunctions in several autoimmune and inflammatory diseases. Experimental periodontitis was induced by placing silk ligature around mandibular first molars. Sick mice were treated intraperitoneally with either P140 or a control, scrambled peptide. After 10 days, mandibles were harvested and bone loss was measured by micro-CT. Immune cells infiltration was studied by histological analyses. Cytokines levels and autophagy-related markers expression were evaluated by qRT-PCR and western blotting. A comparison with non-affected mice revealed significant alterations in the autophagy processes in mandibles of diseased mice, especially in the expression of sequestosome 1/p62, Maplc3b, Atg5, Ulk1, and Lamp2. In vivo, we showed that P140 normalized the dysregulated expression of several autophagy-related genes. In addition, it diminished the infiltration of activated lymphocytes and pro-inflammatory cytokines. Unexpectedly P140 decreased the extent of bone loss affecting the furcation and alveolar areas. Our results indicate that P140, which was safe in clinical trials including hundreds of autoimmune patients with systemic lupus erythematosus, not only decreases the inflammatory effects observed in mandibular tissues of ligation-induced mice but strikingly also contributes to bone preservation. Therefore, the therapeutic peptide P140 could be repositioned as a decisive breakthrough for the future therapeutic management of periodontitis.

DOI： 10.1007/s00018-022-04537-2

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老人介護施設における要介護高齢者や介護職員と歯学部生を電子的に繋いだPBL演習の取組

縄稚久美子, 前田あずさ, 兒玉直紀, 萬田陽介, 菊谷武, 窪木拓男

老年歯科医学 37 ( 2 ) 162 - 162 2022.9

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