Faculty Profiles - NASU Yasutomo

Papers - NASU Yasutomo

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腹腔鏡下精索静脈瘤手術の経験 : 第80回日本泌尿器科学会総会

大枝忠史, 山根享, 志田原浩二, 小澤秀夫, 那須保友, 公文裕巳, 大森弘之

日本泌尿器科学会雑誌 84 ( 1 ) 224 - 224 1993

Mucinous adenocarcinoma of the prostate: A case report

T. Watanabe, K. Hata, Y. Nasu, H. Ohmori

Nishinihon Journal of Urology 55 ( 11 ) 1654 - 1657 1993

Hyperthermotherapy for penile cancer

Kuroda, M., Makihata, E., Asaumi, J., Nishikawa, K., Gao, X.S., Nakagawa, T., Kimoto, S., Hiraki, Y., Tsushima, T., Nasu, Y., Ohmori, H., Kawasaki, S.

Japanese Journal of Clinical Radiology 38 ( 4 ) 1993

Intra-arterial infusion chemotherapy for superficial bladder cancer

T. Saika, S. Kaku, T. Tsushima, Y. Nasu, M. Takamatsu, M. Noda, Y. Matsumura, H. Ohmori

Nishinihon Journal of Urology 55 ( 3 ) 360 - 364 1993

Renal cyst with cholesterol crystals: A case report

T. Watanabe, Y. Nasu, H. Kumon, H. Ohmori

Nishinihon Journal of Urology 55 ( 11 ) 1658 - 1661 1993

Squamous cell carcinoma of the bladder: Two case reports

S. Kaku, T. Tsushima, Y. Nasu, M. Noda, T. Saika, M. Takamatsu, H. Ohmori

Nishinihon Journal of Urology 55 ( 7 ) 1134 - 1137 1993

Combination chemotherapy with cis-platinum and ifosfamide for advanced prostate cancer: Preliminary report

T. Saika, T. Tsushima, Y. Nasu, M. Noda, M. Takamatsu, S. Kaku, H. Ohmori, Y. Matsumura

Nishinihon Journal of Urology 55 ( 6 ) 829 - 832 1993

PROPHYLACTIC INTRAVESICAL INSTILLATION THERAPY IN PATIENTS WITH SUPERFICIAL BLADDER CANCER:Results of a Randomized Prospective Study

Tsushima Tomoyasu, Nasu Yasutomo, Abeki Naoki, Noda Masatoshi, Saika Takashi, Ohmori Hiroyuki, Kobashi Kenji, Ozaki Yujiro, Matsumura Yosuke, Tanahashi Toyoko, Namba Katsuichi, Shiraga Tsuyoshi, Takamoto Hitoshi, Araki Tohru, Takeda Katsuji, Asahi Toshihiko, Akaeda Teruaki

The Japanese Journal of Urology 83 ( 8 ) 1314 - 1321 1992

Publisher：The Japanese Urological Association

A randomized prospective study was conducted for the purpose of investigating the efficacy of intravesical chemoprophylaxis of superficial bladder cancers. Eligible patients were randomized into three groups: 1) adriamycin (ADM) group; intravesical instillation with 50mg of ADM dissolved in 100ml physiological saline, 2) mitomycin C (MMC) group; intravesical instillation with 30mg of MMC dissolved in 100ml of physiological saline, 3) control group; transurethral resection or transurethral coagulation only. The characteristic features of our protocol consisted of frequent (six times) instillations of the drugs within two weeks after transurethral resection, followed by instillations on two consecutive days at four-week intervals for two years. Furthermore, large quantities (100ml) of instillation fluid containing relatively low concentrations of the drugs (500μg/ml for ADM or 300μg/ml for MMC) were employed. One hundred and forty-four patients have been submitted to the study; 110 patients were fully evaluable for recurrence and 34 patients were eliminated as non-evaluable patients. The cumulative five-year non-recurrence rates of the patients with multiple tumors were 32% in the MMC group, 25% in the ADM group and 7% in the control group. The cumulative non-recurrence rates of the ADM and MMC groups were significantly higher than that of the control group. It is considered that this instillation therapy with ADM and MMC is useful for preventing the recurrence of superficial bladder cancers.

DOI： 10.5980/jpnjurol1989.83.1314

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Other Link： http://search.jamas.or.jp/link/ui/1993101168

HISTOPATHOLOGICAL STUDY OF METALLOTHIONEIN IN BLADDER CANCER AND RENAL CELL CARCINOMA

Saika Takashi, Tsushima Tomoyasu, Nasu Yasutomo, Akebi Naoki, Noda Masatoshi, Kobashi Kenji, Matsumura Yousuke, Ohmori Hiroyuki

The Japanese Journal of Urology 83 ( 5 ) 636 - 642 1992

Publisher：The Japanese Urological Association

Metallothionein (MT) is a low molecularmetal binding protein with multiple biological functions. Recently, MT has been implicated as a factor involved in resistance to anticancer drugs, which presumably inactivates anticancer drugs, including cisplatin, and doxorubicin. In this report, we investigated the relationship of MT expression with the clinical features in bladder cancer and renal cell carcinoma. In 35 cases of bladder cancer, 10 cases of renal cell carcinoma and 3 cases of normal mucosa of bladder, the expression of MT was immunohistologically examined by avidinebiotin-peroxidase (ABC) staining of paraffin-embedded tissue specimens with anti-MT antibody. Intense MT expression was noted in all cases of normal mucosa of bladder. MT was detected in 10 of 35 cases of bladder cancer, with the incidence of MT expression being significantly higher increases with lower pathological tumor grade. MT was detected in 8 of 10 cases of renal cell carcinoma, and all of the their normal renal tubules showed more intense staining. A number of hypotheses can be proposed from these observations. First, our observation of decreased MT expression in poorly differentiated carcinomas, which are the more proliferating tumors, this suggests correlation of MT expression with proliferative status of cancer. Second, the higher incidence of MT expression in renal cell carcinoma than in bladder cancer may suggest that it is a factorresponsible for the lower efficacy of chemo-therapy in renal cell carcinoma than in bladder cancer.

DOI： 10.5980/jpnjurol1989.83.636

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Other Link： http://search.jamas.or.jp/link/ui/1992251205

Phase 2 study of 5'-DFUR for bladder and prostatic cancer Reviewed

H. Ohmori, Y. Matsumura, J. Ochi, K. Kobashi, N. Akebi, T. Saika, K. Nanba, T. Tanahashi, T. Josen, Y. Nasu, M. Saegusa, Y. Ozaki, M. Hara, T. Asahi, N. Ike, T. Tsushima, N. Mitsuhata, T. Akagi, T. Kaeda

Japanese Journal of Cancer and Chemotherapy 18 ( 13 ) 2307 - 2314 1991

Language：Japanese Publishing type：Research paper (scientific journal)

Phase 2 study of 5'-DFUR in bladder and prostatic cancer was conducted at 15 collaborative institutions including Okayama University. 5'-DFUR was orally administered to patients at a daily dose of 800-1200 mg for more than 4 weeks. Forty-one patients with bladder cancer and 12 patients with prostatic cancer were evaluated. The response rate for bladder cancer was 31.7% (CFR, 1 case: PR, 12 cases), against no response with prostatic cancer. Moreover, the concentration of 5-FU in bladder tumors was confirmed to be high. Adverse reactions such as diarrhea, anorexia, and nausea were observed. Thus, 5'-DFUR seems to be useful for the treatment of bladder cancer.

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ISOANTIGENS ABH IN BLADDER TUMORS AS AN INDICATOR OF MALIGNANT POTENTIAL The Staining Pattern by PAP Method and its Correlation with Prognosis

Saegusa Michihisa, Nasu Yasutomo, Kumon Hiromi, Matsumura Yosuke, Ohmori Hiroyuki

The Japanese Journal of Urology 81 ( 2 ) 196 - 203 1990

Publisher：The Japanese Urological Association

Blood group antigens (BGA) were stained by PAP methods and the relation between staining pattern (classified into five types: I, II, IIIa, IIIb and IV) and tumor prognosis was examined in 54 patients with primary superficial bladder tumor. The recurrence rate was significantly higher in BGA negative (Type IIIb or IV) or Type IIIa cases than in antigen positive (Type I or II) cases. Stage-up was observed only in BGA negative cases. Although staining pattern of recurrent tumor differed from that of primary tumor in some cases, it is believed that prediction of malignant potential should be performed at the primary development, when tumor has not been influenced by treatments. With regard to the relation between staining pattern and tumor prognosis, no significant difference was found between the cases of A, B and AB blood groups and those of O group.

DOI： 10.5980/jpnjurol1989.81.196

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Other Link： http://search.jamas.or.jp/link/ui/1990217480

A COMBINED LIGHT AND SCANNING ELECTRON-MICROSCOPY ON HUMAN URINARY CYTOLOGY Reviewed

H KUMON, Y NASU, Y MATSUMURA, H OHMORI, T TANAKA

JOURNAL OF ELECTRON MICROSCOPY 32 ( 1 ) 27 - 32 1983

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