Faculty Profiles - NASU Yasutomo

Papers - NASU Yasutomo

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Partial cystectomy in the treatment of invasive bladder cancer

Tomoyasu Tsushima, Takanori Murakami, Shin Ebara, Nobuyuki Kusaka, Shunko Kaku, Yoshiyuki Miyaji, Yasuo Yamamoto, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Ohmori

Nishinihon Journal of Urology 60 ( 5 ) 397 - 401 1998.5

Language：Japanese Publishing type：Research paper (international conference proceedings)

Forty-eight patients with localized muscle-invasive bladder cancer underwent partial cystectomy. Their median age was 70 years. Of these patients, 67% had G3 tumors, and 40% had stage pT3b or pT4 tumors. Nine patients received neoadjuvant therapy. Thirty-one patients received adjuvant chemotherapy and 21 received postoperative radiotherapy, among whom 19 received adjuvant chemo-radiotherapy. The median follow-up was 38 months for all patients, and 68 months for the surviving patients. The cause-specific 5- year survival rate was 63%, while the non-recurrence 5-year survival rate was 58%. Univariate analysis of prognostic factors was carried out with regard to cause-specific survival. Prognosis was statistically better in patients with tumors less than 2cm in diameter, in those with stages pT2 and 3a disease, and in those without hydronephrosis. Partial cystectomy can be recommended in certain clearly selected patients with localized muscle-invasive bladder cancer.

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Clinical Evaluation of Serum Prostate-Specific Antigen-Alpha^1-Antichymotrypsin Complex Values in Diagnosis of Prostate Cancer: A Cooperative Study

KURIYAMA Manabu, UENO Kazuya, UNO Hiromi, KAWADA Yukimichi, AKIMOTO Susumu, NODA Masatoshi, NASU Yasutomo, TSUSHIMA Tomoyasu, OHMORI Hiroyuki, SAKAI Hideki, SAITO Yasushi, MEGURO Norio, USAMI Michiyuki, KOTAKE Toshihiko, SUZUKI Yuji, ARAI Yoichi, SHIMAZAKI Jun

Int. J. Urol. 5 ( 1 ) 48 - 54 1998

Gene therapy for prostate cancer

Bangma C.H, Thompson T.C, Timme T.L, Scardino P.T, Yang G, Wang J, Nasu Y, Park S.H, Hull J.W

Prostate Cancer and Prostatic Diseases 1 ( S-1 ) 33 1998

Prospective Randomized Comparative Study of Antibiotic Prophylaxis in Urethrocystoscopy and Urethrocystography

TSUGAWA Masaya, MONDEN Kohichi, NASU Yoshitsugu, KUMON Hiromi, OHMORI Hiroyuki

Int J Urol 5 ( 5 ) 441 - 443 1998

Absorption of epirubicin instilled intravesically immediately after transurethral resection of superficial bladder cancer Reviewed

T Tsushima, Y Miyaji, M Noda, Y Nasu, H Kumon, H Ohmori

UROLOGIA INTERNATIONALIS 60 ( 3 ) 161 - 164 1998

Language：English Publishing type：Research paper (scientific journal) Publisher：KARGER

As postoperative adjuvant therapy for superficial bladder cancer, intravesical instillation therapy is commonly conducted. In this case, from the view point of prevention of intraoperative dissemination, commencement of instillation therapy at an early postoperative period is preferred. However, increased drug permeability is suspected because of damage to the bladder mucosa during operation. Therefore, this study was conducted to investigate the plasma level of epirubicin (EPI) instilled immediately after transurethral operation. EPI (20 mg/40 ml or 50 mg/100 ml) was instilled immediately after a transurethral operation, and retained in the bladder for 1 h. Blood samples were obtained before instillation, as well as 30, 60, 120 and 240 min after instillation, and EPI levels were assayed. The mean EPI concentrations (ng/ml) among the 20-mg/40 ml group (n = 5) were <2.5 and <2.0 at 30 and 60 min, respectively, after which they were undetectable. The 50-mg/100 ml group (n = 5) recorded 5.0, 4.4 and <3.0 after 30, 60 and 120 min, respectively, and after 240 min it was undetectable. Intravesical instillation of EPI immediately after a transurethral operation causes a small increase in the plasma level and it is thought to cause small systemic side effects.

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Statistical analysis of factors affecting progression of superficial bladder cancer

Naoki Akebi, Tomoyasu Tsushima, Kenji Kobashi, Yasutomo Nasu, Yoshiyuki Miyaji, Takanori Murakami, Hiroyuki Ohmori, Hiromi Kumon

Nishinihon Journal of Urology 60 ( 10 ) 692 - 697 1998

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Kyushu University

Three hundred and three consecutive patients with superficial bladder cancer, stages Ta and T1, who were initially treated at the Department of Urology, Okayama University Medical School between 1965 and 1990, were retrospectively reviewed regarding tumor progression. One hundred and fifty (49.5%) patients had disease recurrence, while 24 (7.0%) patients subsequently developed deep muscle invasion or distant metastasis. The interval between initial treatment and progression ranged from 8 to 122 months, with a median of 45.5 months. Of these 24 patients, 7 (29.2%) were initially diagnosed as stage Ta and 17 (70.8%) as stage T1, whilst 3 (12.5%) were diagnosed as histological grade 1, 17 (70.8%) as grade 2 and 4 (16.7%) as grade 3. Twelve factors including age, sex, clinical symptoms, number of tumors, tumor size, tumor shape, tumor involvement of the bladder neck, stage, grade, interval to first recurrence, urine cytology, and urethral recurrence were selected as variables of tumor progression and analyzed statistically. From univariate analysis of variables obtained from the initial diagnosis of 303 cases, nonpapillary tumor shape, stage T1, positive urine cytology and interval to first recurrence within 12 months were found to be significantly correlated with tumor progression. However, multivariate analysis using Cox's proportional hazards model revealed that only tumor shape and interval to first recurrence were of significant prognostic value. In 150 cases with recurrent tumors, the most unfavorable factor with regard to tumor progression as determined from the clinical records of each case was also analyzed statistically. Univariate analysis showed that urethral recurrence, grade 3, stage T1 and nonpapillary tumor shape were all significant predictors for progression. Further multivariate analysis using logistic model indicated that urethral recurrence was the most important factor followed by the histological grade.

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INHIBITION OF A PRIMARY MOUSE PROSTATE TUMOR WITH ADENOVIRAL MEDIATED HERPES SIMPLEX VIRUS THYMIDINE KINASE GENE TRANSDUCTION ＆ GANCICLOVIR THERAPY

Hall S.J, Yang G, Mutchnik S.E, Adier H.L, Nasu Y, Timme T.L, Woo S.L.C, Thompson T.C

The Journal of Urology 157 ( S-4 ) 368 1997

THE EFFECT OF A GONADOTROPIN-RELEASING HORMONE AGONIST ON BONE MINERAL DENSITY OF PROSTATIC CANCER PATIENTS

Noda M, Tsushima T, Nasu Y, Ohmori H

The Journal of Urology 157 ( S-4 ) 232 1997

Study of the Nephrotoxicity of Iron Oxide Fumes Released by Welding in an Experimental Model

Noda M, Tsushima T, Nasu Y, Kumon H, Ohmori H, Okada S

Pathophysiology 4 221 - 226 1997

尿路上皮癌における細胞表面糖鎖とDNA量の同時解析に関する基礎的・臨床的研究

宮地禎幸, 郭春鋼, 那須保友, 津島知靖, 大森弘之

日本泌尿器科学会雑誌 88 ( 2 ) 275 - 275 1997

Clinical Studies on Advantages and Safety of Visual Laser Ablation for Patients with Benign Prostatic Hyperplasia

Nasu Y, Watanabe T, Kumon H, Ohmori H

Int J Urol 3 ( S-1 ) S53 - S54 1996

New Technological Methods of Managing BPH －Visual Laser Ablation of Prostate(VLAP):Non-contact－

Nasu Y, Kumon H, Ohmori H

Japanese Journal of Endourology and ESWL 9 ( 2 ) 137 - 139 1996

Relationship of intracellular concentration and duration of contamination of pirarubicin and adriamycin in human bladder cancer cell lines and human bladder normal mucosa cell line Reviewed

T. Saika, T. Tsushima, Y. Nasu, N. Akebi, H. Ohmori

Japanese Journal of Cancer and Chemotherapy 23 ( 7 ) 905 - 909 1996

Language：Japanese Publishing type：Research paper (scientific journal)

To establish a method for reasonable clinical use of adriamycin (ADM) and pirarubicin (THP) in the intravesical chemotherapy for superficial bladder cancer, intracellular concentrations of these drugs were examined in culture cell lines (T-24, T-24/ADM and FHS736b1) with variable durations of contamination. The intracellular concentration of THP showed a plateau at 15- 30 min. contamination in T-24, and in T-24/ADM, and showed the time dependence of contamination in FHS736b1, human normal bladder mucosa cell line. The intracellular concentration of ADM showed the time dependence of contamination in T-24, T-24/ADM and FHS736b1. And these concentrations of THP were 20 times higher than those of ADM. In conclusion, it seems better that THP was retained for 5-15 min. in the bladder in the intravesical chemotherapy, from the point of view of drug efficacy and preventing side effects. And it seems good that ADM was retained for more than 30 min. in the case with drug sensitive tumors.

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膀胱癌培養細胞におけるアポトーシス関連物質の検討

郭春鋼, 那須保友, 津島知靖, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 402 - 402 1996

膀胱癌におけるFlSH法による染色体数的異常の検討

井上高明, 那須保友, 津島知靖, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 519 - 519 1996

尿路癌における細胞表面糖鎖とDNA量の同時解析に関する基礎的・臨床的研究

宮地禎幸, 那須保友, 津島知靖, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 518 - 518 1996

上部尿路疾患におけるヘリカルCTによる三次元画像診断

橋本英昭, 那須保友, 公文裕巳, 大森弘之, 清哲朗, 安井光太郎, 平木祥夫

日本泌尿器科学会雑誌 87 ( 2 ) 322 - 322 1996

前立腺癌の診断におけるsystematic biopsyの検討

村上貴典, 野田雅俊, 那須保友, 津島知靖, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 315 - 315 1996

前立腺癌診断におけるfree PSA/total PSA(TOSOH)の有用性

野田雅俊, 津島知靖, 那須保友, 大森弘之

日本泌尿器科学会雑誌 87 ( 2 ) 251 - 251 1996

Prostatic cancer presenting as palpable lymph-node metastases: A case report

Ryuji Fujita, Atsushi Nagai, Masaya Tsugawa, Yasutomo Nasu, Tomoyasu Tsushima, Hiroyuki Ohmori

Nishinihon Journal of Urology 58 ( 1 ) 41 - 43 1996

Language：Japanese Publishing type：Research paper (scientific journal)

A 48-year-old man visited our hospital complaining of nodules in the left neck. Physical examination revealed firm, smooth and movable masses of 1 to 2 cm in diameter in the bilateral neck, and in the left supraclavicular, bilateral axillar anti bilateral inguinal regions. On digital rectal examination, a hen's egg sized, smooth and elastic firm prostate was observed. The serum prostatic acid phosphatase and prostate-specific antigen levels were elevated. Needle biopsy of the prostate showed poorly differentiated adenocarcinoma. Treatment with LH-RH agonist, diethylstilbestrol diphosphate, ifosfamide and cisplatinum was effective and the patient has responded well. The enlarged lymph nodes have since shrunk markedly, and the serum prostatic acid phosphatase and prostate-specific antigen levels have also fallen to normal levels. This case indicated the presence of an unusual prostatic cancer in which non-regional superficial lymph-node metastases occurred.

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