Faculty Profiles - NASU Yasutomo

Papers - NASU Yasutomo

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腎細胞癌に対する腎部分切除術の検討

白崎義範, 新良治, 那須保友, 津島知靖, 公文裕巳, 市川孝治, 光畑直喜, 西光雄, 林俊秀

日本泌尿器科学会雑誌 92 ( 2 ) 248 - 248 2001

経尿道的手術直後に膀胱内注入されたピラルビシン(THP)の血漿および血球への移行

津島知靖, 那須保友, 雑賀隆史, 新良治, 白崎義範, 日下信行, 公文裕巳, 橋本英昭, 森永修, 石井和史, 大和豊子, 上原偵也, 赤枝輝明

日本泌尿器科学会雑誌 92 ( 2 ) 258 - 258 2001

前立腺癌に対するIn Situ Gene Therapy : マウス前立腺癌転移モデルを用いた併用療法とその投与時期の検討

江原伸, 雑賀隆史, 佐藤威文, 那須保友, 津島知靖, TERRY TIMME L., GUANG YANG, TIMOTHY THOMPSON C., 公文裕巳

日本泌尿器科学会雑誌 92 ( 2 ) 266 - 266 2001

内分泌療法抵抗性再燃前立腺癌に対するbicalutamideの効果

中田哲也, 倉繁拓志, 村田匡, 白崎義範, 賀来春紀, 新良治, 那須保友, 津島知靖, 公文裕巳, 渡辺雄一, 宮地禎幸, 牧佳男, 高本均

日本泌尿器科学会雑誌 92 ( 2 ) 284 - 284 2001

LH-RH agonist投与中止後におけるテストステロン値の推移について

賀来春紀, 中田哲也, 倉繁拓志, 日下信行, 新良治, 那須保友, 津島知靖, 公文裕巳

日本泌尿器科学会雑誌 92 ( 2 ) 391 - 391 2001

Efficacy of ultrasound contrast agent in the diagnosis and treatment of prostate diseases

Masaya Tsugawa, Katsumi Sasaki, Takashi Senoo, Ryoji Arata, Yasutomo Nasu, Hiromi Kumon

Nishinihon Journal of Urology 62 ( 4 ) 176 - 181 2000.4

Language：Japanese Publishing type：Research paper (scientific journal)

The efficacy of an ultrasound contrast agent (Levovist(TM)) for ultrasonography during prostatic biopsy and transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia (BPH) was examined. Between March and September, 1999, 25 patients who were suspected of having prostate cancer according to PSA, MRI or transrectal ultrasonography (TRUS), underwent transrectal prostatic biopsy. The ultrasound contrast agent was administered intravenously at a concentration of 300 mg/ml and at a rate of 1.0 ml/min. Similarly, between January and September, 1999, for 3 patients with symptomatic BPH, changes in blood flow signals in the prostate gland during TUMT were observed using transrectal color Doppler ultrasound using the ultrasound contrast agent. The ultrasound contrast agent was administered intravenously at a concentration of 300 mg/ml and at a rate of 0.5 ml/min. Prostatic cancer was detected in 17 (68.0%) of the 25 patients. Evaluating all the samples obtained, the sensitivity and specificity were 70.6% and 84.3% for TRUS, 64.7% and 86.1% for color Doppler ultrasound, and 64.7% and 87.0% for enhanced color Doppler ultrasound, respectively. Although this is only a preliminary report, we were able to conclude that the use of an ultrasound contrast agent during prostatic biopsy can enable the lesion to be depicted clearly, however there is little impact on the improvement of sensitivity and specificity in the diagnosis of prostate cancer. The signals of blood flow in the prostate gland increased just after the initiation of TUMT in all patients. Avascular areas in the prostate appeared about 10 minutes after TUMT treatment and expanded time dependently in all patients. These avascular areas were correlated with the coagulative necrosis areas detected by MRI 2 weeks after treatment. The real-time observation of avascular areas using an ultrasound contrast agent during TUMT for BPH has become possible, and this will be helpful in establishing the treatment conditions for each patient.

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Ureteropyeloscopy for upper urinary tract lesions - Its techniques and applications

Masaya Tsugawa, Yasutomo Nasu, Hiromi Kumon

Nishinihon Journal of Urology 62 ( 4 ) 147 - 152 2000.4

Language：Japanese Publishing type：Research paper (scientific journal)

Since 1987, we have employed ureteropyeloscopic diagnosis and treatment for the patients with unilateral renal bleeding of uncertain etiology and upper urinary tract transitional cell carcinoma. The techniques and procedures have improved dramatically with the advancement of endoscopes and other related instruments. In this article, we introduce our recent procedures for ureteropyeloscopy with special reference to technical pitfalls. In addition, our clinical results are also reported. Between July, 1987 and September, 1999, 59 patients with essential hematuria were examined and treated endoscopically. The duration of gross hematuria was 1 to 144 months (average 29.5 months). The right side was affected in 21 patients, the left in 37, and both in 1 patient. The localized bleeding point was detected in 41 out of 59 patients. All these lesions were treated endoscopically. Among the 41 patients with localized bleeding, transitional cell carcinoma was found in 2, hemangioma in 14, minute venous rupture in 20, varices in 3 and calculus in 2. Between July, 1987 and September, 1999, we carried out endoscopic treatment for 16 patients with upper urinary tract transitional cell carcinoma. There were 3 patients who died of renal pelvic carcinoma, but there were no patients who died of ureteral carcinoma. However, the prognosis of patients with bilateral lesions, diffuse non-papillary carcinoma or preoperative positive urine cytology was particularly poor. In conclusion, ureteropyeloscopy is useful for the patients with unilateral renal bleeding of uncertain etiology. In cases of transitional cell carcinoma of the upper urinary tract with diffuse non-papillary carcinoma and/or preoperative positive urine cytology, total nephroureterectomy should be considered.

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Primary malignant lymphoma of the adrenal gland diagnosed by percutaneous needle biopsy: A report of two cases

Daisuke Manabe, Atsushi Nagai, Tomoyasu Tsushima, Kazushi Manabe, Koichi Monden, Yasutomo Nasu, Hiromi Kumon

Nishinihon Journal of Urology 62 ( 3 ) 136 - 139 2000.3

Language：Japanese Publishing type：Research paper (scientific journal)

Two cases of adrenal malignant lymphoma were treated at our hospital. Case 1 was a 68-year-old man whose chief complaint was right flank pain. He was referred to us for treatment of bilateral adrenal tumors which had been detected at another hospital. A diagnosis of non Hodgkin's lymphoma (diffuse large cell type) was confirmed by US-guided needle biopsy. The patient did not respond to cisplatin-based combination chemotherapy and died within a week. Case 2 was a 72-year-old woman who visited our hospital complaining of left flank pain. CT scan revealed bilateral bulky masses confined to the adrenal gland. As in Case 1, US-guided needle biopsy revealed non-Hodgkin's lymphoma (diffuse large cell type). Despite partial response following CHOP chemotherapy, thrombocytopenia progressed and the patient died after four courses of chemotherapy.

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Prognosis of patients with stage T1 and T2 renal cell carcinoma according to tumor size

Tomoyasu Tsushima, Yasutomo Nasu, Nobuyuki Kusaka, Ryoji Arata, Haruki Kaku, Yasuo Yamamoto, Yoshiyuki Miyaji, Mikio Kishi, Hiromi Kumon

Nishinihon Journal of Urology 62 ( 2 ) 55 - 58 2000.2

Language：Japanese Publishing type：Research paper (scientific journal)

In an attempt to define the relationship between tumor size and survival, the records of 307 patients with renal cell carcinoma were analyzed. Larger tumors were associated with a worse survival in T1-2 patients. When T1-2 patients were divided according to a tumor size of 70 mm, there was a statistically significant difference between the two groups (p = 0.01). There was no statistically significant difference between T1 and T2 patients divided according to a tumor size of 25 mm (p = 0.15). It would thus seem to be more appropriate to divide T1 and T2 patients into two groups according to a tumor size of 70 mm rather than 25 mm.

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Noninvasive urodynamic evaluation of bladder outlet obstruction using Doppler ultrasonography

OZAWA H.

Urology 56 ( 3 ) 408 - 412 2000

Reliability of color doppler ultrasound urodynamics in the evaluation of bladder outlet obstruction

Yew Yoong Ding, Ozawa H, Yokoyama T, Nasu Y, Chancellor M.B, Kumon H

Urology 56 ( 6 ) 967 - 971 2000

The clinical value of contrast-enhanced color doppler ultrasound : is it really useful in the diagnosis of prostate cancer?

Nasu Y, Saika T, Arata R, Tsugawa M, Tsushima T, Kumon H, Seno T

J Urol 163 ( 4 ) 280 2000

前立腺癌遺伝子治療の基礎研究と臨床研究について

那須保友

日本泌尿器科学会雑誌 91 ( 3 ) 138 - 138 2000

腎細胞癌に対する腎摘除術後の対側腎機能の検討

白崎義範, 那須保友, 津島知靖, 公文裕巳, 明比直樹

日本泌尿器科学会雑誌 91 ( 3 ) 269 - 269 2000

ヒト腎細胞癌におけるシクロオキシゲナーゼ2の発現

山本康雄, 津島知康, 那須保友, 雑賀隆史, 新良治, 賀来春紀, 日下信行, 倉繁拓志, 公文裕巳

日本泌尿器科学会雑誌 91 ( 3 ) 186 - 186 2000

マウス前立腺同所移植モデルを用いた前立腺癌に対する治療評価系の構築 : 超音波細経プローブを用いたモニタリング法の確立

日下信行, 那須保友, 新良治, 雑賀隆史, 津島知靖, 公文裕巳

日本泌尿器科学会雑誌 91 ( 3 ) 260 - 260 2000

尿路変向の違いによる膀胱全摘術後患者のQOL

新良治, 日下信行, 雑賀隆史, 那須保友, 津島知靖, 公文裕巳, 武田克治, 光畑直喜, 西光雄, 陶山文三

日本泌尿器科学会雑誌 91 ( 3 ) 342 - 342 2000

Retroperitoneoscopic pyelotomy combined with transposition of crossing vessels for ureteropelvic junction obstruction

Atsushi Nagai, Hideaki Hashimoto, Masaya Tsugawa, Yasutomo Nasu, Hiromi Kumon

Nishinihon Journal of Urology 61 ( 4 ) 308 - 312 1999.4

Language：Japanese Publishing type：Research paper (international conference proceedings)

We have developed a new approach comprising retroperitoneoscopic pyelotomy combined with transposition of crossing vessels for ureteropelvic junction obstruction. From February 1997 to March 1998, we identified 6 cases of ureteropelvic junction obstruction due to crossing vessels by helical computed tomography. 'Ureterovascular hydronephrosis' characterized by malrotated renal pelvis with anterior crossing vessels was observed in 4, while ureteropelvic junction obstruction with posterior crossing vessels was observed in 2. Two female and 4 male patients, ranging from 9 to 60 years of age underwent retroperitoneoscopic surgery. After insertion of an endoureterotomy stent cystoscopically, retroperitoneoscopic surgery was carried out in the standard kidney position. Crossing vessels were found after removal of the periureteral adipose tissue and were freed from the ureter. After complete detachment, the vessels were transposed to a higher position in the renal pelvis and fixed with absorbable clips using peripelvic tissue. The resulting ureteropelvic junction was incised longitudinally for about 1.5 cm with a potassium titanyl phosphate (KTP) laser in 4 cases, although this incision was omitted in 2 cases where ureteropelvic junction obstruction appeared perfectly normal. The postoperative course was uneventful in all cases and the stent was removed 4-8 weeks postoperatively. Postoperative excretory urography (IVP) showed significant resolution of the hydronephrosis in 5 patients, but no significant resolution in 1 patient, who had not received the pyelotomy. This procedure is a simple but reliable method for ureterovascular hydronephrosis and related conditions as a minimally invasive alternative to conventional antegrade or retrograde endopyelotomy.

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Primary non-Hodgkin lymphoma of the ureter Reviewed

H Hashimoto, M Tsugawa, Y Nasu, T Tsushima, H Kumon

BJU INTERNATIONAL 83 ( 1 ) 148 - 149 1999.1

Effective steroid therapy for retrovesical inflammatory pseudotumor in children: A case report

Shunko Kaku, Tomoyasu Tsushima, Masaya Tsugawa, Yasutomo Nasu, Hiromi Kumon, Hiroyuki Ohmori

Nishinihon Journal of Urology 60 ( 9 ) 669 - 672 1998.9

Language：Japanese Publishing type：Research paper (scientific journal)

A 10-year-old boy complained of fever and frequent miction pain. CT scan revealed right hydronephrosis and a retrovesical mass. Based on the histological diagnosis of a specimen obtained by transrectal needle biopsy, the mass was determined to be an inflammatory pseudotumor. Steroid therapy was selected, resulting in the complete disappearance of the mass. Although surgery is the preferred treatment, steroid therapy should be considered in cases with this rare condition.

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