Faculty Profiles - MAKINO Takuma

Papers - MAKINO Takuma

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MACC1 expression is an indicator of recurrence in early-stage glottic cancer. Reviewed International journal

Takuma Makino, Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Soshi Takao, Hidenori Marunaka, Kentaro Miki, Naoki Akisada, Yusuke Akagi, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

Japanese journal of clinical oncology 50 ( 4 ) 392 - 398 2020.4

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer. METHODS: Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n = 52) were immunohistochemically analyzed to explore MACC1 expression. The clinical records associated with each case were also examined. Recurrence-free survival (RFS) was estimated using the Kaplan-Meier method, and between-group RFS differences were assessed using the log-rank test. The multivariate analyses were evaluated using the Cox's proportional-hazard model. RESULTS: Patients were treated with only radiotherapy (RT) (n = 37, including 18 with T1 disease and 19 with T2 disease), or with chemoradiotherapy (CRT) (n = 15, including 1 with T1 disease and 14 with T2 disease). Eleven patients demonstrated local recurrence and two patients experienced cervical lymph node recurrence. Tumor specimens were MACC1-positive in 9 of the 13 (69.2%) patients with local or neck recurrence, and 7 of the 11 (63.6%) patients with local recurrence. The RFS rate of patients who were treated with only RT was significantly lower than that of patients who were treated with CRT (P = 0.0243). The RFS rate was significantly lower in cases with MACC1 expression than in those without MACC1 expression (P = 0.0003). Multivariate analysis revealed that MACC1 expression was an independent risk factor of local recurrence (P = 0.0016). CONCLUSION: MACC1 is an independent indicator of recurrence related to RFS in early-stage glottic cancer.

DOI： 10.1093/jjco/hyz206

Clinical significance of cytoplasmic IgE-positive mast cells in eosinophilic chronic rhinosinusitis Reviewed International journal

Gion Y, Okano M, Koyama Y, Oura T, Nishikori A, Orita Y, Tachibana T, Marunaka H, Makino T, Nishizaki K, Sato Y

Int J Mol Sci 7 ( 21 ) 2020

Language：English Publishing type：Research paper (scientific journal)

Cross-linking of antigen-specific IgE bound to the high-affinity IgE receptor (FcεRI) on the surface of mast cells with multivalent antigens results in the release of mediators and development of type 2 inflammation. FcεRI expression and IgE synthesis are, therefore, critical for type 2 inflammatory disease development. In an attempt to clarify the relationship between eosinophilic chronic rhinosinusitis (ECRS) and mast cell infiltration, we analyzed mast cell infiltration at lesion sites and determined its clinical significance. Mast cells are positive for c-kit, and IgE in uncinated tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. The number of positive cells and clinicopathological factors were analyzed. Patients with ECRS exhibited high levels of total IgE serum levels and elevated peripheral blood eosinophil ratios. As a result, the number of mast cells with membranes positive for c-kit and IgE increased significantly in lesions forming NP. Therefore, we classified IgE-positive mast cells into two groups: membrane IgE-positive cells and cytoplasmic IgE-positive cells. The amount of membrane IgE-positive mast cells was significantly increased in moderate ECRS. A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. The number of cytoplasmic IgE-positive mast cells was significantly increased in moderate and severe ECRS. A positive correlation was observed between the cytoplasmic IgE-positive cells and the radiological severity score, the ratio of eosinophils in the blood, and the total IgE level. These results suggest that the process of mast cell internalization of antigens via the IgE receptor is involved in ECRS pathogenesis.

DOI： 10.3390/ijms21051843

An adolescent case of maxillary ameloblastic fibrosarcoma Reviewed

Yohei Noda, Tomoyasu Tachibana, Hidenori Marunaka, Kazunori Kuroda, Takuma Makino, Shift Kariya

Otolaryngology - Head and Neck Surgery (Japan) 92 ( 10 ) 851 - 856 2020

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Igaku-Shoin Ltd

We report about 17-year-old girl with maxillary ameloblastic fibrosarcoma. She underwent surgery and received postoperative chemotherapy comprising ifos-famide and doxorubicin. Considering fertility preservation. mature oocytes were cryopreserved before initiating chemotherapy. Two years after chemotherapy, there were no signs of recurrence. In adolescent and young adult patients, treatment and fertility preservation should be considered in the management of head and neck cancer.

The efficacy of OK-432 sclerotherapy on thyroglossal duct cyst and the influence on a subsequent surgical procedure. Reviewed International journal

Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yoji Wani, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Yasuharu Sato, Kazunori Nishizaki

Acta oto-laryngologica 139 ( 9 ) 788 - 792 2019.9

Language：English Publishing type：Research paper (scientific journal)

Background: Although there are studies regarding the efficacy of OK-432 sclerotherapy on thyroglossal duct cyst (TDC), its effects on surgical procedure following this therapy have not been properly described. Objectives: The present study aimed to delineate the prognostic factors of OK-432 sclerotherapy in patients with TDC and investigate its influence on subsequent surgical procedure and the histological characteristics in patients with poor response to OK-432 sclerotherapy. Material and methods: We conducted a retrospective analysis of the medical records of 20 TDC patients treated with OK-432 sclerotherapy. Results: Of the 20 patients, OK-432 sclerotherapy was effective in 5 patients (25.0%). OK-432 showed a lower effective rate in multilocular cysts (9.1%) than in unilocular cysts (44.4%), although not significantly. Five cases were treated with surgery following OK-432 sclerotherapy. There was no significant difference in the operating time and the amount of bleeding between patients with and without OK-432 sclerotherapy. From the results of the histological examination of the cyst wall, two cases had stratified squamous epithelium and two cases showed the absence of lymphocyte infiltration. Conclusion and significance: OK-432 sclerotherapy is an acceptable initial treatment for TDC, especially in unilocular cysts, because of lack of influence on surgical procedure.

DOI： 10.1080/00016489.2019.1633019

KRAS mutations in tongue squamous cell carcinoma. Reviewed International journal

Yusuke Akagi, Tomoyasu Tachibana, Yorihisa Orita, Yuka Gion, Hidenori Marunaka, Takuma Makino, Kentaro Miki, Naoki Akisada, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

Acta oto-laryngologica 139 ( 7 ) 647 - 651 2019.7

Language：English Publishing type：Research paper (scientific journal)

Background: p16INK4a (p16) expression in tongue cancer (TC) is reportedly not associated with human papilloma virus (HPV). Mutations of KRAS in cancer cells are most frequently observed within codon 12. However, few reports have investigated the association between KRAS mutations and p16 status in TC. Objectives: This study aimed to evaluate the influence of KRAS mutations on TC. Methods: Clinical records and surgically resected specimens of 85 TC patients were analyzed. Tumor samples were analyzed for mutations of KRAS located within codons 12 and 13. p16 staining was performed and considered positive in cases with moderate to strong nuclear and cytoplasmic staining. Results: Positive p16 staining was observed in 10 cases (11.8%). A KRAS mutation was detected in one case (1.2%). The case with KRAS mutation showed negative p16 staining. Despite being at an early stage, the patient died of lung metastasis at 43 months from initial treatment. Conclusions and Significance: KRAS mutations are not associated with p16 expression in TC and may predict poor prognosis in TC patients. Further analysis of mutations in regions other than codons 12 and 13 of KRAS will be necessary to determine the relationship between KRAS mutations and prognosis of this disease.

DOI： 10.1080/00016489.2019.1610574

Spontaneous closure of traumatic tympanic membrane perforation following long-term observation. Reviewed International journal

Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Michihiro Nakada, Yohei Noda, Yasuharu Sato, Kazunori Nishizaki

Acta oto-laryngologica 139 ( 6 ) 487 - 491 2019.6

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Traumatic tympanic membrane perforation (TTMP) is usually managed conservatively because most close spontaneously within a few months. Nevertheless, spontaneous closure of TTMP during long-term observation has not been well described in the literature. OBJECTIVES: The present study investigated factors associated with spontaneous closure of TTMP, and the characteristics of cases exhibiting spontaneous closure following long-term observation. MATERIALS AND METHODS: The medical records of 40 patients with TTMP who visited the authors' hospital were retrospectively reviewed. RESULTS: Spontaneous closure was observed in 27 (67.5%) patients. The healing period was <2 weeks in 6 cases, <4 weeks in 9, <3 months in 5, <6 months in 3, and ≥6 months in 4. All four cases in which spontaneous closure took ≥6 months exhibited a sign of spontaneous closure at 6 months following injury. Perforation in contact with the malleus was associated with a lower frequency of spontaneous closure. CONCLUSIONS AND SIGNIFICANCE: In TTMP, surgery should be considered in patients who exhibit perforation in contact with the malleus. However, it has also been suggested that long-term observation may be a viable treatment option when a sign of spontaneous closure is observed within 6 months following injury.

DOI： 10.1080/00016489.2019.1592225

Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx. Reviewed

Makoto Abe, Masaya Iwamuro, Yoshiro Kawahara, Hiromitsu Kanzaki, Seiji Kawano, Takehiro Tanaka, Munechika Tsumura, Takuma Makino, Yohei Noda, Hidenori Marunaka, Kazunori Nishizaki, Hiroyuki Okada

Acta medica Okayama 73 ( 2 ) 109 - 115 2019.4

Language：English Publishing type：Research paper (scientific journal)

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61.0% and 50.8% had a history of esophageal cancer and head and neck cancer, respectively. The median tumor size was 15 mm, and 75.7% of the lesions were located at the piriform sinus. The en bloc resection rate was 94.9%. Treatment-related adverse events occurred in 8 cases, but there was no treatment-related death. The lateral margin was positive for neoplasm in 3 lesions (4.3%) and inconclusive in 27 lesions (38.6%), but no local recurrence was observed. Cervical lymph node metastasis was observed in 6 patients, and was successfully treated by cervical lymph node dissection. The three-year overall survival rate was 91.5% (95%CI: 76.6-97.3%) and the cause-specific survival rate was 97.6% (95%CI: 84.9-99.7%). In conclusion, ESD for superficial pharyngeal cancer was safe and effective. "Resect and watch" is probably a feasible and rational strategy for treatment of patients with superficial pharyngeal cancer.

DOI： 10.18926/AMO/56646

Young adult patients with squamous cell carcinoma of the tongue strongly express p16 without human papillomavirus infection. Reviewed International journal

Tachibana T, Orita Y, Gion Y, Miki K, Ikegami K, Marunaka H, Makino T, Akagi Y, Akisada N, Tsumura M, Ito T, Yoshino T, Nishizaki K, Sato Y

Acta oto-laryngologica 139 ( 1 ) 80 - 84 2019.1

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Long-term smoking and drinking are known to contribute to the onset of tongue cancer (TC). However, the increasing incidence of TC in younger adults has been suggested to be associated with other factors. OBJECTIVES: The present study investigated the relationship between TC and human papillomavirus (HPV) infection. MATERIAL AND METHODS: Clinical records and surgically resected specimens from 86 patients (<40-years-old, n = 12; ≥40-years-old, n = 74) with TC were analyzed. Strong nuclear and cytoplasmic p16 staining was considered positive. HPV DNA (high-risk subtypes: 16, 18, 31, 33, 35, 52b, and 58; low-risk subtypes: 6 and 11) was detected using consensus primer-mediated polymerase chain reaction. RESULTS: Strong p16 expression was observed in 10 (11.6%) patients. HPV DNA was detected in 9 (10.5%) patients (high-risk subtypes, n = 2; low-risk subtypes, n = 7). Strong p16 expression was observed more frequently among younger adults than among older adults (33.3% vs. 8.1%; p = .045). p16 staining did not correlate with the detection of HPV DNA (correlation coefficient, 0.113; p = .300). CONCLUSIONS AND SIGNIFICANCE: In TC, p16 expression was not associated with HPV infection, suggesting that it may be caused by a different mechanism.

DOI： 10.1080/00016489.2018.1541506

Factors that prolong the duration of recovery in acute rhinosinusitis with orbital complications. Reviewed

Tachibana T, Kariya S, Orita Y, Nakada M, Makino T, Haruna T, Matsuyama Y, Komatsubara Y, Naoi Y, Sato Y, Nishizaki K

Acta Otolaryngol 10 1 - 5 2019

Factors that prolong the duration of recovery in acute rhinosinusitis with orbital complications. Reviewed International journal

Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Takenori Haruna, Yuko Matsuyama, Yasutoshi Komatsubara, Yuto Naoi, Yasuharu Sato, Kazunori Nishizaki

Acta oto-laryngologica 139 ( 1 ) 52 - 56 2019

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Regarding prognostic factors of acute rhinosinusitis (ARS) with orbital complications, there are few studies including adult cases. OBJECTIVES: The present study aims to delineate prognostic factors of ARS with orbital complications. MATERIAL AND METHODS: We conducted a retrospective analysis of medical records of 21 patients (6 pediatric and 15 adult patients) with ARS with orbital complications. The duration of recovery was defined as the time from initial diagnosis to complete resolution of local findings and all symptoms. Orbital complications due to postoperative cysts or mycosis were excluded. RESULTS: Twenty-one patients comprised 11 males and 10 females. Chandler's classification showed group I in 4, group II in 8, and group III in 9. None of six pediatric patients required any surgical intervention, whereas five adult patients (23.8%) underwent surgical intervention. The average period of recovery was 8.1 days. In univariate analysis, the duration of recovery was significantly longer among adult cases (p < .01) and cases with Chandler's groups II-III (p = .019). In multivariate analysis, adult patients had a significantly longer duration of recovery than pediatric patients (p = .027). CONCLUSION AND SIGNIFICANCE: The present study suggested that ARS with orbital complications may have prolonged clinical course in adults.

DOI： 10.1080/00016489.2018.1539516

Computed Tomography Findings for Diagnosing Follicular Thyroid Neoplasms. Reviewed

Makino T, Orita Y, Tachibana T, Marunaka H, Miki K, Akisada N, Akagi Y, Usui Y, Sato Y, Yoshino T, Nishizaki K

Acta medica Okayama 72 ( 6 ) 577 - 581 2018.12

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

Since no diagnostic method has been established to distinguish follicular thyroid carcinoma (FTC) from follicular thyroid adenoma (FTA), surgery has been the only way to reach a diagnosis of follicular neoplasm. Here we investigated the computed tomography (CT) features of follicular neoplasms, toward the goal of being able to identify specific CT features allowing the preoperative differentiation of FTC from FTA. We retrospectively analyzed the cases of 205 patients who underwent preoperative CT of the neck and were histopathologically diagnosed with FTC (n=31) or FTA (n=174) after surgery between January 2002 and June 2016 at several hospitals in Japan. In each of these 205 cases, non-enhanced and contrast-enhanced CT images were obtained, and we analyzed the CT features. On univariate analysis, inhomogeneous features of tumor lesions on contrast-enhanced CT were more frequently observed in FTC than in FTA (p=0.0032). A multivariate analysis identified inhomogeneous features of tumor lesions on contrast-enhanced CT images as an independent variable indicative of FTC (p=0.0023). CT thus offers diagnostic assistance in distinguishing FTC from FTA.

DOI： 10.18926/AMO/56375

Canal wall-down procedure with soft posterior meatal wall reconstruction in acquired cholesteatoma: focus on postoperative middle ear status* Reviewed International journal

Tomoyasu Tachibana, Shin Kariya, Yorihisa Orita, Michihiro Nakada, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Kazunori Nishizaki

Acta Oto-Laryngologica 138 ( 8 ) 695 - 700 2018.8

Language：English Publishing type：Research paper (scientific journal) Publisher：Taylor and Francis Ltd

Objectives: We reviewed surgical results of canal wall-down tympanoplasty (CWDT) with soft posterior meatal wall reconstruction (SWR) for acquired cholesteatoma (AC), and identified factors associated with surgical outcomes. Methods: Results from 119 ears with AC (pars flaccida, n = 99
pars tensa, n = 20) that underwent CWDT with SWR were retrospectively reviewed. We defined postoperative balloon-like retraction (PBR) with web formation, which needed reoperation to clean accumulated cerumen, as postoperative deep retraction pocket (PDRP). Results: Residual cholesteatoma was found in 11 ears (9.2%). Seven residual cholesteatomas were treated with outpatient operation. Seven ears (5.9%) showed PDRP. A transcanal approach was applied to all PDRPs. Postoperative mastoid reaeration was observed in 57 ears (47.9%). No factors significantly associated with residual cholesteatoma or PDRP were identified. The frequency of postoperative mastoid reaeration was significantly higher among cases with young age (&lt
50 years), stage I cholesteatoma, or type I ossiculoplasty. Conclusion: CWDT with SWR showed low rates of residual cholesteatoma or postoperative deep retraction pocket (PDRP). Most residual cholesteatomas and PDRPs could be dealt with using a minimally invasive procedure. Young age, stage I cholesteatoma, and type I ossiculoplasty were associated with postoperative mastoid reaeration. This procedure seems fully feasible for surgical treatment of AC.

DOI： 10.1080/00016489.2018.1439593

Prognostic factors and importance of recognition of adult croup Reviewed International journal

Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Yasutoshi Komatsubara, Yuko Matsuyama, Yuto Naoi, Michihiro Nakada, Yasuharu Sato, Kazunori Nishizaki

Acta Oto-Laryngologica 138 ( 6 ) 579 - 583 2018.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Taylor and Francis Ltd

Objectives: Croup, or laryngotracheobronchitis, is a common disease in childhood. On the other hand, to our knowledge, there are only 14 cases in six English literatures describing adult croup (AC). The clinical features of AC have not been well known. Methods: We conducted a retrospective analysis of medical records of 18 patients with AC during the period from 2008 to 2016. Results: None of the 18 patients required an urgent airway intervention. Univariate analysis indicated that the duration of symptoms was significantly longer in patients with cough (p &lt
.01) and younger patients (age &lt
60, p =.037). The duration of subglottic edema was significantly longer in female (p =.035), patients with high levels of CRP (≥1 mg/dL, p =.049), and patients with cough symptom (p =.035). Conclusions: Female, young age (&lt
60 years), the symptom of cough, and high levels of CRP should be recognized as signs of prolonged AC. It is important to confirm the diagnosis of AC by laryngoscopic examination, which also help to avoid airway intervention.

DOI： 10.1080/00016489.2017.1422140

Neck metastasis in patients with T1-2 supraglottic cancer Reviewed International journal

Tomoyasu Tachibana, Yorihisa Orita, Hidenori Marunaka, Sei-ichiro Makihara, Misato Hirai, Yuka Gion, Kana Ikegami, Kentaro Miki, Takuma Makino, Yasuyuki Noyama, Yasutoshi Komatsubara, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

Auris Nasus Larynx 45 ( 3 ) 540 - 545 2018.6

Language：English Publishing type：Research paper (scientific journal) Publisher：Elsevier Ireland Ltd

Objectives: Unlike glottic cancer, supraglottic cancer often presents with neck metastases. This different might be attributable to the location of the primary lesion. This study aimed to clarify the relationships between the sublocation of T1-2 supraglottic cancer, human papillomavirus (HPV) infection, neck metastasis, and prognosis of supraglottic cancer. Methods: This retrospective clinical study investigated 55 Japanese patients with T1-2 supraglottic cancer treated between 1994 and 2015. Results: Of 55 patients with T1-2 supraglottic cancer, neck metastasis was present at initial diagnosis in 14 patients (25.5%). Presence of neck metastasis was the only factor associated with worse prognosis of T1-2 supraglottic cancer (p = 0.004). In multivariate analysis, age &lt
70 years (p = 0.033) and sublocation of the primary lesion in the superior epilaryngeal portion (p = 0.017) were significantly associated with presence of neck metastasis in multivariate analysis. Twelve (27.9%) of 43 patients showed positive results for human papillomavirus infection. However, human papillomavirus infection was not associated with prognosis, presence of neck metastasis, or primary lesion sublocation in T1-2 supraglottic cancer. Conclusion: Relatively young patients with supraglottic cancer at the superior epilaryngeal portion are more likely to show neck metastasis. Human papillomavirus infection was not associated with frequency of neck metastasis.

DOI： 10.1016/j.anl.2017.06.002

Squamous cell carcinoma of the bilateral external auditory canals Reviewed

Shin Kariya, Yohei Noda, Munechika Tsumura, Takuma Makino, Hidenori Marunaka, Kazunori Nishizaki

Otolaryngology - Head and Neck Surgery (Japan) 90 ( 7 ) 577 - 582 2018.6

Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Igaku-Shoin Ltd

Squamous cell carcinoma of the external auditory canal is an unusual head and neck malignancy with a reported incidence of between 1 to 6 cases per million population per year. We presented a case of Squamous cell carcinoma of the bilateral external auditory canals in a 69-year-old female. Right side tumor mas treated with surgery. Left side tumor was treated with radiotherapy. Five years after treatment, the recurrence of the tumor was found in the left side, and the surgery was performed. No recurrence or metastasis was observed at 10 years follow-up.

耳後部有茎皮弁にて外耳道再建した両側性外耳道扁平上皮癌の1例 Reviewed

假谷伸, 野田洋平, 津村宗近, 牧野琢丸, 丸中秀格, 西崎和則

耳鼻咽喉科・頭頸部外科 90 ( 7 ) 577 - 582 2018.6

Language：Japanese Publisher：(株)医学書院

症例は69歳女性で、7年前に右耳漏を主訴に受診し、右外耳道扁平上皮癌と診断された。術前放射線治療施行後に、外側側頭骨切除術および遊離腹直筋皮弁による再建術を施行した。その後、術後放射線治療を施行した。右外耳道癌の経過観察目的で受診した際に左外耳道下壁の皮膚不整を指摘された。左外耳道扁平上皮癌の診断で電子線照射、腔内照射を施行し、腫瘍は消失した。標準純音聴力検査では、右耳の混合性難聴を認めた。定期再診時に左外耳道に不整を認めた。左外耳道より生検を行い、病理組織診断は扁平上皮癌であった。左外耳道には過去の治療により高線量の放射線照射が行われており、さらなる放射線治療は不可能と判断し、左外耳道腫瘍切除手術を行った。摘出標本の病理組織学的検査にて高分化型扁平上皮癌と診断した。術後、皮弁は生着し、術後3週間で外耳道内は乾燥した。現在、最終手術から約10年を経過して両側とも外耳道癌の再発や転移は認めない。

椎周囲間隙に発生した頸部筋間脂肪腫例 Reviewed

牧野琢丸, 橘智靖, 小松原靖聡

耳鼻咽喉科臨床 111 ( 6 ) 395 - 399 2018.6

Authorship：Lead author Language：Japanese Publisher：耳鼻咽喉科臨床学会

症例は48歳男性で、約2年前から右頸部腫瘤を自覚した。右頸部に可動性不良な弾性軟の腫瘤を認めた。頸部超音波検査では胸鎖乳突筋の背側、内頸静脈の後方に、境界明瞭で内部が均一な等〜やや高エコーの腫瘤を認めた。MRIでは胸鎖乳突筋と肩甲挙筋の間、およびその背側に連続するダンベル型の嚢胞様の腫瘤として描出され、内部は均一でT1強調画像、T2強調画像でともに高信号を呈し、脂肪抑制画像にて信号が抑制された。全身麻酔下に仰臥位で腫瘍摘出術を行った。摘出した腫瘤の大きさは70×55×21mmで、色調は黄色であった。病理組織所見では、成熟した脂肪組織の増生から成り、筋線維束は認めなかったことから、単純脂肪腫と診断した。術後明らかな神経症状は認めず、現在外来にて経過観察中である。

Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2018&ichushi_jid=J00580&link_issn=&doc_id=20180615230005&doc_link_id=130007382299&url=https%3A%2F%2Fci.nii.ac.jp%2Fnaid%2F130007382299&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_1.gif

Laryngeal squamous cell papilloma is highly associated with human papillomavirus Reviewed International journal

Yorihisa Orita, Yuka Gion, Tomoyasu Tachibana, Kana Ikegami, Hidenori Marunaka, Seiichiro Makihara, Yasuhiko Yamashita, Kentaro Miki, Takuma Makino, Naoki Akisada, Yusuke Akagi, Miyuki Kimura, Tadashi Yoshino, Kazunori Nishizaki, Yasuharu Sato

Japanese Journal of Clinical Oncology 48 ( 4 ) 350 - 355 2018.4

Language：English Publishing type：Research paper (scientific journal) Publisher：Oxford University Press

Objective: To delineate the association between characteristics of adult-onset laryngeal squamous cell papilloma and human papillomavirus (HPV) infection. Methods: Clinical records and paraffin-embedded specimens of 77 papilloma patients who had been treated between 1998 and 2014 were collected. Of the 77 cases, 34 were identified in the larynx, 28 in the oral cavity and 15 in the oropharynx. Specimens were investigated by polymerase chain reaction (PCR) to detect HPV 6, 11, 16, 18, 31, 33, 35, 52b and 58, and immunohistochemical (IHC) staining for anti-p16INK4a antibody. Results: In 21 cases (61.8%) with laryngeal squamous cell papilloma, various types of HPV were detected: 14 cases (41.2%) were positive of high-risk HPV, 18 (52.9%) were positive of low-risk HPV and 11 (32.4%) were positive of both high-risk HPV and low-risk HPV. Younger patients (&lt
60 years) showed a higher rate of HPV infection than older patients. Among the 34 cases with laryngeal papilloma, no malignant transformation was observed during the study period. With IHC staining, positive expression of p16 was observed in 20 cases (58.8%). HPV infection and p16-expression were associated with the pathological finding of koilocytosis. Only four cases (14.3%) showed HPV-positivity in the oral cavity, and none of the 15 oropharyngeal cases were positive for HPV, and none of the oral cavity and oropharyngeal cases showed koilocytosis. Results of HPV-PCR and p16-IHC staining were significantly correlated each other. Conclusions: HPV infection is frequently associated with laryngeal squamous cell papilloma, and koilocytosis is a characteristic pathological finding. To the best of our knowledge, this is the first report which have described infections with multiple HPV types in laryngeal papilloma.

DOI： 10.1093/jjco/hyy009

A case of intermuscular lipoma in the perivertebral space Reviewed

Takuma Makino, Tomoyasu Tachibana, Yasutoshi Komatsubara

Practica Oto-Rhino-Laryngologica 111 ( 6 ) 395 - 399 2018

Authorship：Lead author Language：Japanese Publishing type：Research paper (scientific journal) Publisher：Society of Practical Otolaryngology

We describe our experience of a case of intermuscular lipoma located in the perivertebral space. The patient was a 48-year-old male who presented with the chief complaint of a right neck swelling, first noticed about two years earlier. Cervical ultrasonography and MRI revealed a tumorous lesion expanding into the perivertebral space. Intraoperatively, there were no adhesions between the lipoma and the surrounding tissue. Manual ablation of the lipoma was effective in the deep region, where the lipoma could not be visualized directly. We successfully accomplished complete resection of the lipoma without any serious complications. In the management of intermuscular lipomas expanding into the perivertebral space, surgical treatment should be considered, because resection can be accomplished with little risk of postoperative complications.

DOI： 10.5631/jibirin.111.395

A case of a fish bone in the neck removed using CT- guided hookwire placement Reviewed

Yasutoshi Komatsubara, Tomoyasu Tachibana, Takuma Makino, Yuto Naoi, Aiko Shimizu, Mayu Uga, Akihito Mitsumori

Otolaryngology - Head and Neck Surgery (Japan) 89 ( 10 ) 849 - 853 2017.9

Language：Chinese Publishing type：Research paper (scientific journal) Publisher：Igaku-Shoin Ltd

A 67-year-old woman complained of right sided neck pain and a swelling at right sided neck. CT showed a severe inflammatory change and a linear calcification in the right neck region. We could not identify the foreign body in the initial surgery. After placing a hook-wire near the linear calcification under CT guide, we could safely remove a fish bone. We considered that preoperative CT-guided hookwire placement would be very useful for the removal of foreign bodies in the neck.

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