Faculty Profiles - MAKINO Takuma

Papers - MAKINO Takuma

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Candidemia in patients with head and neck cancer: mortality and a novel risk factor Reviewed International journal

Kensuke Uraguchi, Takuma Makino, Shin Kariya, Youhei Noda, Hidenori Marunaka, Akira Doi, Kenichi Kozakura, Soshi Takao, Mizuo Ando

Supportive Care in Cancer 30 ( 7 ) 5921 - 5930 2022.7

Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

PURPOSE: Candidemia is a bloodstream infection (BSI) by Candida spp. and is associated with high mortality. However, there have been few reports about BSI in head and neck cancer (HNC). We aimed to evaluate the impact of candidemia in patients with HNC and compared it with bacteremia. STUDY DESIGN: A multicenter retrospective study. METHODS: We retrospectively analyzed 83 BSI episodes in HNC (2011 to 2020) and divided them into the candidemia and bacteremia groups. We then compared the survival rate and risk factors for candidemia between the groups. RESULTS: The overall cumulative incidence (risk) of candidemia in BSI was 12 out of 83 episodes (14.5%). The 1-year mortality for the bacteremia and candidemia groups was 33.3% and 58.3%, respectively (log-rank p = 0.041). Broad-spectrum antibiotics (odds ratio [OR]: 29.5; 95% confidence interval [CI], 2.49-350), mucositis (OR 11.0; 95% CI, 1.52-80.1), and malignant wounds (OR 79.5; 95% CI 1.33-4737) were significant risk factors for candidemia in HNC. CONCLUSIONS: Candidemia causes high mortality in patients with HNC. To our knowledge, malignant wounds have not been previously reported as a risk factor for candidemia. For early diagnosis and treatment of candidemia, risk factors should be considered, and antifungal therapy started earlier.

DOI： 10.1007/s00520-022-07010-9

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Other Link： https://link.springer.com/article/10.1007/s00520-022-07010-9/fulltext.html

【今日からの診療に役立つビジュアルでダイレクトに解説する体表・軟部疾患の検査&臨床画像】画像検査各論頭蓋・顔面・頭頸部見逃せない疾患を中心とした頸部腫瘤の鑑別診断

秋定直樹, 牧野琢丸, 安藤瑞生

形成外科 65 ( 増刊 ) S92 - S100 2022.6

ANL Secondary Publication 上顎洞癌に対する動注化学放射線治療の病理学的評価

牧野琢丸, 橘智靖, 假谷伸, 松井裕輔, 松崎秀信, 藤本将平, 折田頼尚, 藤井邦明, 平木隆夫, 佐藤康晴, 金澤右, 西崎和則

日本耳鼻咽喉科頭頸部外科学会会報 125 ( 5 ) 913 - 915 2022.5

【頸部リンパ節を見直す】頸部リンパ節腫脹鑑別の手順頸部リンパ節腫脹の視診と触診について

牧野琢丸

JOHNS 38 ( 3 ) 268 - 270 2022.3

Resection and immediate reconstruction of two pediatric intraosseous capillary mandibular malformations Reviewed

Hiroshi Matsumoto, Tomoyuki Ota, Sho Komagoe, Yohei Noda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa, Kohei Taniguchi, Tomoka Ikeda, Hiroyuki Yanai, Yoshihiro Kimata

European Journal of Plastic Surgery 45 ( 5 ) 831 - 839 2022.1

【新たに薬事承認・保険収載された薬剤・医療資材・治療法ガイド】頭頸部セツキシマブサロタロカンナトリウムを用いた頭頸部イルミノックス治療

牧野琢丸

耳鼻咽喉科・頭頸部外科 94 ( 1 ) 59 - 64 2022.1

小児、思春期・若年がん患者に対する妊孕性温存療法現状と改善の取り組み Reviewed

秋定直樹, 牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2022

外耳道癌治療中に発症した胆道感染症例 Reviewed

秋定直樹, 牧野琢丸, 森本光作, 佐藤明日香, 駿河有莉, 梶原壮平, 浦口健介, 大道亮太郎, 安藤瑞生

頭頸部外科 31 ( 3 ) 301 - 305 2022

Language：Japanese Publisher：(NPO)日本頭頸部外科学会

胆道感染症は,胆石や胆泥により胆汁が鬱滞することで十二指腸乳頭より上行性に細菌感染が生じ発症する。長期間の絶食や経口摂取量不足が続くと胆汁がよどみ,胆石や胆泥発生の好条件となる。また,オピオイド鎮痛薬によるオッジ括約筋機能不全に陥る場合もあり,化学放射線療法中の腹部症状には注意を要する。今回われわれは外耳道癌に対するセツキシマブ併用放射線療法中に発症した胆道感染症を経験した。胆道感染症は診断と治療が遅れれば,開腹手術を要することがある。化学放射線療法を行う機会のある耳鼻咽喉科医は留意すべき治療中合併症のひとつであろう。(著者抄録)

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Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining Reviewed

Yuria Egusa, Midori Filiz Nishimura, Satoko Baba, Kengo Takeuchi, Takuma Makino, Tomoyasu Tachibana, Asami Nishikori, Azusa Fujita, Hiroyuki Yanai, Yasuharu Sato

Diagnostics 11 ( 12 ) 2284 - 2284 2021.12

Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova et al. in 2010 and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma.

DOI： 10.3390/diagnostics11122284

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Morphological Changes and Durability of Skin and Mucosal Flaps in Intraoral and Pharyngeal Reconstructions: Long-term Follow-up and Literature Review for Potential Second Carcinomas. Reviewed

Hiroshi Matsumoto, Yoshihiro Kimata, Tomoyuki Ota, Narushi Sugiyama, Satoshi Onoda, Takuma Makino, Seiko Takeda, Nobuyoshi Mizukawa

Acta medica Okayama 75 ( 6 ) 725 - 734 2021.12

Language：English Publishing type：Research paper (scientific journal)

The long-term changes in tissues implanted in the oral cavity and pharynx after head and neck reconstruction have not been fully evaluated. This study aimed to clarify the morphological changes, long-term durability, and potential for secondary carcinogenesis in such tissues. In our single-center study, the rough morphological changes in 54 cases of intraoral and pharyngeal skin and mucosal flaps were evaluated more than 10 years after flap transfer. In addition, the literature on the development of second carcinomas from skin flaps was reviewed. The mean follow-up period for transferred flaps was 148 months. The reconstruction areas and the probability of morphological changes were significantly correlated (p=0.006), especially in cases with tongue, lower gingiva, and buccal mucosal reconstruction. Free jejunal flap surfaces were well maintained, whereas tubed skin flaps showed severe morphological changes in cases with pharyngeal reconstruction. None of the flaps in our series developed second primary carcinomas. Skin flaps generally had good durability for > 10 years in intraoral environments, while mucosal flaps had better durability for pharyngeal reconstruction. Second squamous carcinomas arising from skin flaps are extremely rare; however, surgeons should take this possibility into consideration and conduct meticulous and long-term follow-up.

DOI： 10.18926/AMO/62813

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PD-L1 expression in tongue squamous cell carcinoma. Reviewed

Naoki Akisada, Kohei Nishimoto, Soshi Takao, Yuka Gion, Hidenori Marunaka, Tomoyasu Tachibana, Takuma Makino, Kentaro Miki, Yusuke Akagi, Munechika Tsumura, Tomohiro Toji, Tadashi Yoshino, Kazunori Nishizaki, Yorihisa Orita, Yasuharu Sato

Medical molecular morphology 54 ( 1 ) 52 - 59 2021.3

Language：English Publishing type：Research paper (scientific journal)

PURPOSE: Immune checkpoint proteins programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) are important therapeutic targets for head and neck cancer. This large-scale case study aimed to analyze tongue squamous cell carcinomas (SCCs) and evaluate the correlation between PD-L1 expression and clinical prognosis. So far, this study is the largest case study on PD-L1 expression in tongue SCCs. METHODS: This is a case-control study that analyzed 121 tongue SCCs. Paraffin-embedded sections and clinical data were obtained retrospectively and immunohistochemistry with PD-L1 was performed. RESULTS: 11.6% contained ≥ 50% of PD-L1-positive cells, 57.1% of these cases had a poor prognosis with nodal metastasis. Among cases of T1/2 primary lesions with nodal metastasis, cases of high PD-L1 expression had a significantly shorter disease-free survival than cases of no PD-L1 expression (p = 0.018). The hazard ratio for high PD-L1 expression was 3.21 (95 per cent CI, 1.26-8.72) compared with no PD-L1 expression after adjusting for other factors. CONCLUSIONS: These data indicate that PD-L1 upregulation in tongue SCCs is associated with a more advanced stage and shorter disease-free survival. PD-1/PD-L1 inhibitors might hence constitute potential adjuvant therapy for tongue SCCs with PD-L1 upregulation.

DOI： 10.1007/s00795-020-00261-7

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Correction to: PD-L1 expression in tongue squamous cell carcinoma. Reviewed

Medical molecular morphology 54 ( 1 ) 68 - 68 2021.3

A Case Report of Spindle Cell Carcinoma with Osteoid and Cartilage Formation in the Tongue Reviewed

Sawako Ono, Takuma Makino, Hiroyuki Yanai, Hotaka Kawai, Kiyofumi Takabatake, Keisuke Nakano, Kenji Nishida, Kohei Taniguchi, Tomohiro Toji, Hitoshi Nagatsuka, Tadashi Yoshino

Reports 4 ( 1 ) 5 - 5 2021.2

Publishing type：Research paper (scientific journal) Publisher：MDPI AG

Spindle cell carcinoma (SCSCC) with osteoid and/or cartilage formation in the head and neck is rare; only one case was reported in the tongue. Herein, we report an SCSCC with osteoid and cartilage formation of the tongue developed in an 85-year-old man, and then review the report.

DOI： 10.3390/reports4010005

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Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion. Reviewed International journal

Tomoyasu Tachibana, Shin Kariya, Yoji Wani, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Kuroda, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Takuma Makino, Yuko Kataoka, Kazunori Nishizaki

Auris, nasus, larynx 48 ( 1 ) 154 - 160 2021.2

Language：English Publishing type：Research paper (scientific journal)

OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

DOI： 10.1016/j.anl.2020.07.017

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Fertility Preservation Therapy Provided for Childhood, Adolescent, and Young Adult Cancer Patients —Current Status and Efforts to Improvement—,小児，思春期・若年がん患者に対する妊孕性温存療法―現状と改善の取り組み― Reviewed

Akisada, N., Makino, T., Sugaya, A., Kataoka, Y., Ando, M., Monden, N., Nakatsuka, M.

Practica Oto-Rhino-Laryngologica 114 ( 12 ) 2021

Application of Lip Biopsy for the Histological Diagnosis of Immunoglobulin G4-Related Disease. Reviewed International journal

Tomoyasu Tachibana, Yorihisa Orita, Yoji Wani, Yasutoshi Komatsubara, Kazunori Kuroda, Yuto Naoi, Yuka Gion, Takuma Makino, Kazunori Nishizaki, Yasuharu Sato

Ear, nose, & throat journal 101 ( 8 ) 145561320971932 - 145561320971932 2020.11

Language：English Publishing type：Research paper (scientific journal)

We describe the case of a 51-year-old woman with immunoglobulin G4-related disease (IgG4-RD) diagnosed using lip biopsy. She reported having bilateral submandibular nodules for a month. Magnetic resonance imaging showed diffuse swelling in the bilateral submandibular glands (SMGs), suggesting inflammatory changes. Laboratory data revealed an elevated level of serum IgG4. Fine needle aspiration cytology of the SMG showed a considerable number of lymphocytes with degeneration but did not demonstrate specific findings for a definitive diagnosis of IgG4-RD. Lip biopsy was performed, and a biopsy specimen from the labial salivary gland showed abundant lymphoplasmacytic infiltration with a large number of IgG4-positive cells. The patient was diagnosed with IgG4-RD based on histological and laboratory findings. Findings of further examinations revealed that the patient had autoimmune pancreatitis, confirming our diagnosis. Four months after prednisolone administration, improvement of the submandibular and pancreatic lesions was observed. One year after the initial presentation, the serum IgG4 level was normalized. In cases of IgG4-RD with salivary gland involvement, lip biopsy might be one of the options for the histological diagnosis of IgG4-RD.

DOI： 10.1177/0145561320971932

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Pathological evaluation of radiotherapy and concomitant intraarterial cisplatin for maxillary sinus cancer. Reviewed International journal

Takuma Makino, Tomoyasu Tachibana, Shin Kariya, Yusuke Matsui, Hidenobu Matsuzaki, Shohei Fujimoto, Yorihisa Orita, Kuniaki Katsui, Takao Hiraki, Yasuharu Sato, Susumu Kanazawa, Kazunori Nishizaki

Auris, nasus, larynx 47 ( 5 ) 881 - 886 2020.10

Authorship：Lead author Language：English Publishing type：Research paper (scientific journal)

OBJECTIVE: Since 2010, we have mainly performed surgical treatment following radiotherapy and concomitant intraarterial cisplatin (RADPLAT) for locally advanced maxillary sinus cancer (MSC). The present study investigated treatment results and pathological evaluations following RADPLAT for MSC. METHODS: Pathological response to RADPLAT was evaluated using surgical specimens. Pathological response was graded in accordance with the classification method that Shimosato reported in 1964, as grade V (no tumor cells remain in any of section), grade IV, III, II, I, and 0. Five-year overall and disease-specific survival rates were estimated using Kaplan-Meier methods. Univariate analyses of correlations between recurrence of MSC and other clinicopathological parameters were evaluated using the chi-square or Fisher's exact tests. RESULT: 19 patients were enrolled in this study, 5 patients showed T3 disease and 14 had T4 disease. One patient demonstrated local recurrence and 3 patients experienced distant metastasis. The 5-year overall survival rate was 67.1% (T3, 50.0%; T4, 69.6%), and the 5-year disease-specific survival rate was 81.9% (T3, 100%; T4, 76.0%). Histological response was categorized as grade V in 9 cases. No significant risk factors for residual cancer were identified. CONCLUSION: Our study suggested that RADPLAT not only has a low risk of side effects, but also could represent an effective procedure for locally advanced MSC by pathological evaluation. Increasing the therapeutic intensity of RADPLAT might provide an effective modality to avoid highly invasive surgery.

DOI： 10.1016/j.anl.2020.04.004

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Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. Reviewed International journal

Yasutoshi Komatsubara, Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Kazunori Kuroda, Yuto Naoi, Yuko Kataoka, Yasuharu Sato, Shin Kariya, Kazunori Nishizaki

Acta oto-laryngologica 140 ( 9 ) 773 - 778 2020.9

Language：English Publishing type：Research paper (scientific journal)

Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

DOI： 10.1080/00016489.2020.1767303

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AYA世代女子に発症した上顎エナメル上皮線維肉腫の1例 Reviewed

野田洋平, 橘智靖, 丸中秀格, 黒田一範, 牧野琢丸, 假谷伸

耳鼻咽喉科・頭頸部外科 92 ( 10 ) 851 - 856 2020.9

Language：Japanese Publisher：(株)医学書院

症例は17歳女性で、左上歯肉部に軽度の疼痛を自覚しており、生検でエナメル上皮線維肉腫が疑われたため、さらなる精査および加療を目的に当院受診した。左側上顎第二大臼歯の周囲歯肉にび漫性の淡赤色調の膨隆を認めた。CTでは上顎洞後壁に骨破壊を伴う軟部陰影を認めた。MRIでは、病変は左上顎骨から上顎洞にかけて液体成分と充実成分が混在する、造影効果を伴う長径約6cmの腫瘤影として描出された。以上より上顎エナメル上皮線維肉腫と診断し、外科的切除に加え、術後5週目より術後化学療法としてイホスファミドおよびドキソルビシンを4コース施行した。化学療法施行後のMRIおよびPET/CTにて左頬骨の骨髄内に異常陰影を認め、再発の可能性が疑われたため、初回手術より6ヵ月後に切除範囲を追加し上顎全摘を施行した。現在、化学療法後約2年経過するが明らかな再発徴候はなく、形態および機能面で良好な経過が得られている。

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耳下腺分泌癌の1経験例 Reviewed

藤本将平, 牧野琢丸, 津村宗近, 丸中秀格, 野田洋平, 假谷伸, 西崎和則

口腔・咽頭科 33 ( 2 ) 105 - 109 2020.6

Authorship：Corresponding author Language：Japanese Publisher：日本口腔・咽頭科学会

分泌癌は、2017年に改定された新WHO分類において新たに加えられた唾液腺悪性腫瘍であるが、耳鼻咽喉科医からの報告例が未だ少なく、臨床的特徴が明らかでない。症例は61歳男性で、左耳下腺癌cT3N0M0の診断にて手術を行い、病理組織学的検査の結果、分泌癌と診断した。術後2年が経過した時点で肺転移を認めたが、患者の希望で経過観察とした。その後、転移病変は緩徐に増大しているが長期に担癌生存している。分泌癌は低悪性度癌の経過をたどると考えられているが、なかには急激な転帰をたどるものや遠隔転移死の報告もあるため、引き続き厳重な経過観察が必要である。(著者抄録)

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Other Link： https://search.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2020&ichushi_jid=J02661&link_issn=&doc_id=20200626410008&doc_link_id=%2Fei4kouku%2F2020%2F003302%2F008%2F0105-0109%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fei4kouku%2F2020%2F003302%2F008%2F0105-0109%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

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Papers - MAKINO Takuma