Faculty Profiles - MAKINO Takuma

Papers - MAKINO Takuma

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光免疫療法:頭頸部アルミノックス治療の現況光免疫療法後における病理組織学的検討

牧野琢丸, 佐藤康晴, 安藤瑞生

日本癌治療学会学術集会抄録集 62回 OWS1 - 5 2024.10

診断に苦慮した舌内神経鞘腫の1例

深澤茉祐, 牧野琢丸, 手島大雅, 直井勇人, 藤本将平, 安藤瑞生

口腔・咽頭科 37 ( 3 ) 239 - 239 2024.8

頭頸部アルミノックス治療により喉頭温存が可能となった再発下咽頭癌症例

手島大雅, 牧野琢丸, 深澤茉祐, 直井勇人, 藤本将平, 安藤瑞生

口腔・咽頭科 37 ( 3 ) 254 - 254 2024.8

Adverse Reactions of Photoimmunotherapy Invited Reviewed

Takuma Makino

The Journal of Japan Society for Laser Surgery and Medicine 45 ( 2 ) 89 - 95 2024.7

A case of an electric toothbrush tip penetrating from the oral cavity to the submandibular gland. Reviewed International journal

Naoki Akisada, Takuma Makino, Yuto Naoi, Yoshinori Taguchi, Yuto Moriwaki, Mizuo Ando

Clinical case reports 12 ( 6 ) e8987 2024.6

3Dバイオプリンターを用いたCAFとがん細胞の位置関係についての検討

直井勇人, 長崎譲慈, 秋定直樹, 藤本将平, 牧野琢丸, 冨樫庸介, 安藤瑞生

頭頸部癌 50 ( 2 ) 159 - 159 2024.5

舌根部癌に対する頭頸部アルミノックス治療の検討

牧野琢丸, 松井裕輔, 藤本将平, 秋定直樹, 直井勇人, 平木隆夫, 安藤瑞生

頭頸部癌 50 ( 2 ) 188 - 188 2024.5

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024.5

上顎再建遊離腓骨移植による上顎再建

松本洋, 太田智之, 加藤基, 武田斉子, 牧野琢丸, 安藤瑞生

頭頸部癌 50 ( 2 ) 105 - 105 2024.5

Near-infrared photoimmunotherapy for salivary duct carcinoma Reviewed

Takuma Makino, Yasuharu Sato, Kensuke Uraguchi, Yuto Naoi, Yujiro Fukuda, Mizuo Ando

Auris Nasus Larynx 51 ( 2 ) 323 - 327 2024.4

Combined simultaneous endoscopic endonasal and transcranial surgery using high-definition three-dimensional exoscope for malignant tumors of the anterior skull base. Reviewed International journal

Seiichiro Makihara, Yoshihiro Otani, Kensuke Uraguchi, Aiko Shimizu, Aya Murai, Takaya Higaki, Naoki Akisada, Shohei Fujimoto, Takuma Makino, Joji Ishida, Kentaro Fujii, Takao Yasuhara, Tomoyuki Ota, Hiroshi Matsumoto, Mizuo Ando

Head & neck 46 ( 5 ) 1074 - 1082 2024.3

Language：English Publishing type：Research paper (scientific journal)

BACKGROUND: Advanced surgical interventions are required to treat malignancies in the anterior skull base (ASB). This study investigates the utility of endoscopic endonasal and transcranial surgery (EETS) using a high-definition three-dimensional exoscope as an alternative to traditional microscopy. METHODS: Six patients with carcinomas of varying histopathologies underwent surgery employing the EETS maneuver, which synchronized three distinct surgical modalities: harvesting of the anterolateral thigh flap, initiation of the transnasal technique, and initiation of the transcranial procedure. RESULTS: The innovative strategy enabled successful tumor resection and skull base reconstruction without postoperative local neoplastic recurrence, cerebrospinal fluid leakage, or neurological deficits. CONCLUSION: The integration of the exoscope and EETS is a novel therapeutic approach for ASB malignancies. This strategy demonstrates the potential of the exoscope in augmenting surgical visualization, enhancing ergonomics, and achieving seamless alignment of multiple surgical interventions. This technique represents a progressive shift in the management of these complex oncological challenges.

DOI： 10.1002/hed.27724

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Various arrangements of pharyngeal flap in soft palate reconstruction after cancer treatment Reviewed

Hiroshi Matsumoto, Tomoyuki Ota, Motoi Kato, Takuma Makino, Seiichiro Makihara, Mizuo Ando, Yoshihiro Kimata

Head & Neck 46 ( 7 ) 1573 - 1581 2024.3

Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Background

The pharyngeal flap (PF) is useful for reconstruction of soft palate defects, but effective arrangements of PF for various types of soft palate defects are controversial. Here, we classify three types of soft palate defects and discuss the arrangements of PF and their functional prognosis.

Methods

Reconstruction was performed based on the classification of the defects. Clinical details were collected, and postoperative function was analyzed.

Results

Eight patients were included in the study. The defect sizes ranged from 25 (width) × 40 (depth) to 40 × 60 mm. Six patients underwent pharyngeal flap reconstruction with free‐flap reconstruction, and two underwent pharyngeal flap reconstruction. The pharyngeal flap was harvested at the maximum width of the posterior pharyngeal wall, ranging from 25 to 40 mm in length. Eating and speaking functions were maintained in all patients.

Conclusions

Good postoperative function can be maintained by narrowing the velopharyngeal space with a pharyngeal flap.

DOI： 10.1002/hed.27712

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Extent of thyroidectomy and paratracheal lymph node dissection in total pharyngolaryngectomy for pyriform sinus cancer, and recurrence, survival, and postoperative hypoparathyroidism: A multicenter retrospective study Reviewed

Yosuke Ariizumi, Nobuhiro Hanai, Takahiro Asakage, Akira Seto, Toshifumi Tomioka, Junji Miyabe, Hisashi Kessoku, Takashi Mukaigawa, Go Omura, Masanori Teshima, Daisuke Nishikawa, Yuki Saito, Yukinori Asada, Takuo Fujisawa, Takuma Makino, Hiroshi Nishino, Daisuke Sano, Mitsuhiko Nakahira, Kunihiko Tokashiki, Hirokazu Uemura, Tsutomu Ueda, Akihiro Sakai, Muneyuki Masuda, Takahiro Tsujikawa, Yusuke Hiei, Naoki Nishio, Hidetoshi Matsui, Naomi Kiyota, Akihiro Homma

Head & Neck 46 ( 2 ) 269 - 281 2023.11

Publishing type：Research paper (scientific journal) Publisher：Wiley

Abstract

Background

Total pharyngolaryngectomy (TPL) is standard treatment for hypopharyngeal cancer. However, extensive thyroidectomy and paratracheal nodal dissection (PTND) can cause hypoparathyroidism. We sought to determine the optimum extent of resection.

Methods

We analyzed the clinicopathological information of 161 pyriform sinus cancer patients undergoing TPL from 25 Japanese institutions. Rates of recurrence and risk factors for hypoparathyroidism, as well as incidence of pathological contralateral level VI nodal metastasis and stomal recurrence, were investigated.

Results

The extent of thyroidectomy and nodal dissection were not independent risk factors for recurrence. Incidences of contralateral level VI nodal involvement and stomal recurrence were 1.8% and 1.2%, respectively. Patients undergoing hemithyroidectomy/ipsilateral PTND did not develop stomal recurrence and had the lowest incidence of hypoparathyroidism. Prognosis in patients without tracheostomy prior to hemithyroidectomy/ipsilateral PTND was comparable to that with more extensive resections.

Conclusions

Hemithyroidectomy/ipsilateral PTND may be sufficient for pyriform sinus cancer cases without tracheostomy.

DOI： 10.1002/hed.27572

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Nasopharyngeal low-grade papillary schneiderian carcinoma with cervical metastasis. Reviewed International journal

Kensuke Uraguchi, Kenji Nishida, Takuma Makino, Seiichiro Makihara, Masahiro Tabata, Shin Kariya, Mizuo Ando

Auris, nasus, larynx 50 ( 5 ) 821 - 826 2023.10

Language：English

Low-grade papillary Schneiderian carcinoma (LGPSC) is a rare and newly described type of cancer arising from the Schneiderian epithelium. Owing to cellular atypia, it is difficult to differentiate this type from other papillomas and malignancies. Although this condition remains unclear, it is associated with mortality and recurrence. Therefore, treating physicians should be aware of the possibility of LGPSC for prompt diagnosis and treatment. In this article, we present an additional case of nasopharyngeal LGPSC with cervical lymph node metastasis and reviewed the 14 cases reported thus far in the literature. A 76-year-old female was referred to our department for detailed examination of nasopharyngeal and cervical lymph node tumors detected by positron emission tomography-computed tomography. Based on the biopsy of the nasopharyngeal tumor, we suspected LGPSC. Considering the clinical course and pathological findings, the patient was diagnosed with cervical lymph node metastasis through neck dissection. We performed radiotherapy for the primary lesion of the nasopharynx, which led to the disappearance of the tumor. After 13 months following the radiotherapy, the patient died from a recurrence of retroperitoneal liposarcoma without the recurrence of LGPSC.

DOI： 10.1016/j.anl.2022.12.010

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Application of the Valsalva maneuver to prevent adhesion and deformity after hypopharyngeal endoscopic submucosal dissection. Reviewed International journal

Hironao Sato, Kenta Hamada, Makoto Abe, Takuma Makino, Yoshiro Kawahara

Gastrointestinal endoscopy 98 ( 2 ) 254 - 256 2023.8

Degree of pharyngeal deformation caused by pharyngeal endoscopic submucosal dissection is associated with the incidence of aspiration pneumonia. Reviewed International journal

Makoto Abe, Yoshiro Kawahara, Yuka Obayashi, Yuki Baba, Kenta Hamada, Hiroyuki Sakae, Yoshiyasu Kono, Hiromitu Kanzaki, Masaya Iwamuro, Seiji Kawano, Takuma Makino, Yohei Noda, Hidenori Marunaka, Hiroyuki Okada

Endoscopy international open 11 ( 4 ) E351-E357 2023.4

Language：English Publishing type：Research paper (scientific journal)

Background and study aims Endoscopic submucosal dissection (ESD) is one of the most minimally invasive treatments for superficial squamous cell cancer of the pharynx. However, aspiration pneumonia (AsP) associated with postoperative deformity of the pharynx may occur. The purpose of this study was to investigate the frequency of AsP and the degree of pharyngeal deformity after pharyngeal ESD. Patients and methods This was a retrospective observational study of patients who underwent pharyngeal ESD at Okayama University Hospital between 2006 and 2017. The degree of pharyngeal deformation was assessed using the pharyngeal deformation grade (PDG). The primary endpoint was the frequency of AsP as a long-term adverse event. Results Among the 52 patients enrolled, nine developed aspiration pneumonia, with a 3-year cumulative incidence of 9.0 % (95 % confidence interval [CI], 3.3 %-22.0 %). There were 16, 18, 16, and two patients that had PDG 0, 1, 2, and 3, respectively. Patients with a history of radiotherapy, as a treatment of head and neck cancer (44.4 % vs. 11.6 %; P = 0.02) and the high PDG group (PDG 2 and 3) (77.8 % vs. 25.6 %; P = 0.005) had a significantly higher incidence of AsP. The 3-year cumulative incidence rate of AsP after ESD in the high PDG group was significantly higher than that in the low PDG group (PDG 0 and 1) (23.9 % [95 %CI, 9.2.-49.5%] vs. 0 %; P = 0.03). Conclusions The incidence of aspiration pneumonia in the long-term course after pharyngeal ESD was revealed. The incidence of aspiration pneumonia may be associated with pharyngeal deformity, but further studies are needed.

DOI： 10.1055/a-2033-9707

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5年の経過で増大した上咽頭形質細胞肉芽腫の1例 Reviewed

駿河有莉, 牧野琢丸, 假谷伸, 安藤瑞生

口腔・咽頭科 36 ( 1 ) 48 - 53 2023.3

Language：Japanese Publisher：日本口腔・咽頭科学会

形質細胞肉芽腫(plasma cell granuloma)は形質細胞の増殖を伴う非腫瘍性,反応性の病変である.今回,我々は上咽頭形質細胞肉芽腫の1症例を経験したので報告する.症例は68歳女性であり主訴は鼻閉であった.PET検査で上咽頭に集積が認められ,精査加療を目的に当科を紹介され受診となった.生検で診断は確定できなかったが悪性腫瘍は否定されたため,数年間経過観察をされた後に終診となった.その後5年の経過で上咽頭腫瘤の増大による鼻閉が出現した.鼻閉症状の改善および診断を目的として手術の方針となり,形質細胞肉芽腫の診断となった.確定診断がついていない場合は悪性所見がなくても定期的なフォローアップが必要と考えられる.(著者抄録)

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Other Link： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J02661&link_issn=&doc_id=20230412340008&doc_link_id=10.14821%2Fstomatopharyngology.36.48&url=https%3A%2F%2Fdoi.org%2F10.14821%2Fstomatopharyngology.36.48&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

A Case of Radiation-Induced Osteosarcoma with RB1 Gene Alteration Treated by Skull Base Surgery and Craniofacial Reconstruction. Reviewed

Yuki Matsuda, Yoshihiro Otani, Takao Yasuhara, Mizuo Ando, Takaya Higaki, Takuma Makino, Hiroshi Matsumoto, Tadashi Oyama, Hisakazu Nishimori, Isao Date

Acta medica Okayama 77 ( 1 ) 85 - 90 2023.2

Language：English

A 35-year-old female presented with headache, photophobia and developed sudden loss of vision after having undergone right-side ophthalmectomy and radiochemotherapy for retinoblastoma in infancy. A neoplastic lesion was found in the left middle cranial fossa and was surgically removed. The diagnosis was radiation-induced osteosarcoma with RB1 gene alteration. Although she received chemotherapy for the residual tumor, it progressed 17 months later. Maximal surgical resection with craniofacial reconstruction was required. We utilized two three-dimensional models for surgical planning. She was discharged without neurological deficits other than loss of light perception subsequent to left ophthalmectomy. In cases where retinoblastoma is treated with radiotherapy, long-term follow-up is necessary to monitor for radiation-induced tumor development.

DOI： 10.18926/AMO/64367

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【咽頭癌-最新の治療戦略】転移・再発咽頭癌に対するがん光免疫療法（頭頸部アルミノックス治療）

牧野琢丸

医学と薬学 79 ( 12 ) 1599 - 1603 2022.12

Midline involvement and perineural invasion predict contralateral neck metastasis that affects overall and disease-free survival in locally advanced oral tongue squamous cell carcinoma Reviewed International journal

Maki Akamatsu, Takuma Makino, Shinya Morita, Yohei Noda, Shin Kariya, Tomoo Onoda, Mizuo Ando, Yoshihiro Kimata, Kazunori Nishizaki, Mitsuhiro Okano, Aiko Oka, Kengo Kanai, Yoshihiro Watanabe, Yorihisa Imanishi

Frontiers in Oncology 12 1010252 - 1010252 2022.10

Language：English Publishing type：Research paper (scientific journal) Publisher：Frontiers Media SA

Introduction

Although patients with oral squamous cell carcinoma who develop contralateral neck metastasis (CLNM) have worse survival outcomes than those without CLNM, accurate prediction of occult CLNM in clinically negative contralateral neck (contralateral cN0) remains difficult. This study aimed to identify clinicopathological factors that could reliably predict CLNM in patients with locally advanced (clinical T3 and T4a) tongue squamous cell carcinoma (TSCC).

Patients and methods

The medical data of 32 patients with cT3–4a TSCC who underwent curative surgery between 2010 and 2017 were retrospectively analyzed. The correlation of clinicopathological variables with CLNM was examined using logistic regression analysis. The diagnostic performance of significant variables was evaluated using the area under the receiver operating characteristic curves (AUC). Overall survival (OS) and disease-free survival (DFS) were assessed using a Cox proportional hazards model.

Results

CLNM was eventually confirmed in 11 patients (34.4%). Multivariate logistic regression showed that midline involvement [odds ratio (OR) = 23.10, P = 0.017] and perineural invasion (PNI, OR = 14.96, P = 0.014) were independent predictors of CLNM. Notably, the prediction model comprising a combination of midline involvement and PNI exhibited superior diagnostic performance with an even higher OR of 80.00 (P &lt; 0.001), accuracy of 90.3%, and AUC of 0.876. The multivariate Cox hazards model revealed independent significance of CLNM as an unfavorable prognostic factor for both OS [hazard ratio (HR) = 5.154, P = 0.031] and DFS (HR = 3.359, P = 0.038), as well as that of PNI for OS (HR = 5.623, P = 0.033).

Conclusion

Our findings suggest that coexisting midline involvement and PNI of the primary tumor is highly predictive of CLNM development, which independently affects both OS and DFS in patients with locally advanced TSCC. Such reliable prediction enables efficient control of CLNM by optimizing management of the contralateral cN0 neck, which will likely contribute to improved prognosis of those patients without unnecessarily compromising their quality of life.

DOI： 10.3389/fonc.2022.1010252

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Papers - MAKINO Takuma