研究者詳細 - 片岡　祐子

論文 - 片岡　祐子

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複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリング経験

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 大道亮太郎, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 2 ) 2017年

MRI 検査後に人工内耳インプラント磁石の反転を来した2症例

片岡祐子, 内藤智之, 假谷伸, 菅谷明子, 前田幸英, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 5 ) 2017年

Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy. 国際誌

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Rie Nagayasu, Atsuko Nakagawa, Toru Yamashita, Koji Abe, Kazunori Nishizaki

Acta oto-laryngologica 136 ( 3 ) 266 - 70 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms. METHODS: The shape and threshold of pure-tone audiograms were evaluated for MSA-C (n = 47; mean (± SD) age, 61.6 ± 8.9 years), CCA (n = 16; 62.8 ± 9.5 years), and age-matched controls (n = 169; 62.5 ± 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria. RESULTS: When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208-5.139; p < 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709-6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320-7.969) and 3.692 (95% CI = 1.052-12.957), respectively, significantly higher than in controls.

DOI： 10.3109/00016489.2015.1104722

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当科における小児両側人工内耳50例の検討

長安吏江, 菅谷明子, 假谷伸, 福島邦博, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 西崎和則

小児耳鼻咽喉科 37 ( 1 ) 2016年

海水浴後に罹患したShewanella putrefaciensによる中耳感染症の例

藤本将平, 片岡祐子, 假谷伸, 菅谷明子, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 4 ( 1 ) 2016年

人工内耳装用児のスポーツに関するアンケート調査

片岡祐子, 菅谷明子, 假谷伸, 大道亮太郎, 前田幸英, 福島邦博, 西崎和則

Otology Japan 26 ( 3 ) 2016年

Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. 国際誌

Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yuko Kataoka, Junko Yoshinobu, Yukihide Maeda, Hisashi Ishihara, Takaya Higaki, Kazunori Nishizaki

Acta oto-laryngologica 136 ( 2 ) 136 - 40 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSIONS: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of middle ear diseases. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for cholesteatoma and chronic otitis media. OBJECTIVE: NLRP3 inflammasome is a critical molecule mediating interleukin (IL)-1β responses. However, the expression of NLRP3 in the pathogenesis of cholesteatoma and chronic otitis media has not been fully examined. This study sought to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in middle ear tissues in patients with cholesteatoma or chronic otitis media. METHODS: Middle ear tissue samples were obtained from patients with cholesteatoma or chronic otitis media. Control middle ear samples were collected during cochlear implant surgery of patients without middle ear inflammation. The expression of NLRP3, ASC, and caspase-1 were examined by reverse transcription polymerase chain reaction (RT-PCR) assay and immunohistochemical study. RESULTS: The levels of mRNA of NLRP3, ASC, and caspase-1 were significantly elevated in cholesteatoma and chronic otitis media as compared with that of normal controls. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

DOI： 10.3109/00016489.2015.1093171

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Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants. 国際誌

Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Yuko Kataoka, Yukihide Maeda, Rie Nagayasu, Naomi Toida, Shyuhei Ohmori, Akie Fujiyoshi, Tomoko Taguchi, Ryotaro Omichi, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 79 ( 12 ) 2142 - 6 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Early hearing detection and intervention (EHDI) is critical for achievement of age-appropriate speech perception and language development in hearing-impaired children. It has been 15 years since newborn hearing screening (NHS) was introduced in Japan, and its effectiveness for language development in hearing-impaired children has been extensively studied. Moreover, after over 20 years of cochlear implantation in Japan, many of the prelingual cochlear implant (CI) users have reached school age, and the effect of CI on language development have also been assessed. To identify prognostic factors for language development, audiological/language test scores and demographic factors were compared among prelingual severe-to-profound hearing-impaired children with CI divided into subgroups according to age at first hearing aid (HA) use and whether they received NHS. METHODS: Prelingual severe-to-profound deafened children from the Research on Sensory and Communicative Disorders (RSCD) project who met the inclusion criteria were divided into groups according to the age (in months) of HA commencement (before 6 months: group A, after 7 months: group B), and the presence or absence of NHS (groups C and D). Language development and socio-economic data were obtained from audiological/language tests and a questionnaire completed by caregivers, respectively. RESULTS: In total, 210 children from the RSCD project participated in this study. Group A (n=49) showed significantly higher scores on comprehensive vocabulary and academic achievement (p<0.05) than group B (n=161), with no difference in demographics except for significantly older age in group B. No differences in language scores were observed between group C (n=71) and group D (n=129), although participants of group D was significantly older and had used CIs longer (p<0.05). CONCLUSIONS: Early use of HAs until the CI operation may result in better language perception and academic achievement among CI users with prelingual deafness. A long-term follow-up is required to assess the usefulness of NHS for language development.

DOI： 10.1016/j.ijporl.2015.09.036

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蝸牛におけるステロイド作用機序 Charcot-Marie-Tooth neuropathy関連蛋白、Myelin protein zeroの制御

前田幸英, 假谷伸, 菅谷明子, 片岡祐子, 西崎和則

Otology Japan 25 ( 4 ) 618 - 618 2015年9月

Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy. 国際誌

Yukihide Maeda, Yuko Kataoka, Akiko Sugaya, Shin Kariya, Katsuhiro Kobayashi, Kazunori Nishizaki

Auris, nasus, larynx 42 ( 3 ) 249 - 53 2015年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Charcot-Marie-Tooth disease (CMT) is the most common form of hereditary sensorimotor neuropathy and sometimes involves disorders of the peripheral auditory system. We present a case of steroid-dependent auditory neuropathy associated with CMT, in which the patient experienced 3 episodes of acute exacerbation of hearing loss and successful rescue of hearing by prednisolone. An 8-year-old boy was referred to the otolaryngology department at the University Hospital. He had been diagnosed with CMT type 1 (demyelinating type) at the Child Neurology Department and was suffering from mild hearing loss due to auditory neuropathy. An audiological diagnosis of auditory neuropathy was confirmed by auditory brainstem response and distortion-product otoacoustic emissions. At 9 years and 0 months old, 9 years and 2 months old, and 10 years and 0 months old, he had experienced acute exacerbations of hearing loss, each of which was successfully rescued by intravenous or oral prednisolone within 2 weeks. Steroid-responsive cases of CMT have been reported, but this is the first case report of steroid-responsive sensorineural hearing loss in CMT. The present case may have implications for the mechanisms of action of glucocorticoids in the treatment of sensorineural hearing loss.

DOI： 10.1016/j.anl.2014.11.002

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複数の遺伝子変異を有する難聴者における遺伝カウンセリングの経験

片岡祐子, 菅谷明子, 長安吏江, 前田幸英, 福島邦博, 西崎和則

日本遺伝カウンセリング学会誌 36 ( 2 ) 78 - 78 2015年5月

当科における急性低音障害型感音難聴の治療と予後の検討

菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 118 ( 4 ) 604 - 604 2015年4月

言語評価の後に補聴器装用・言語訓練の開始に至った中等度難聴の一例

中川敦子, 菅谷明子, 福島邦博, 前田幸英, 片岡祐子, 藤吉昭江, 長安吏江, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 232 - 232 2015年4月

Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan. 国際誌

Shuhei Ohmori, Akiko Sugaya, Naomi Toida, Etsuji Suzuki, Masato Izutsu, Tomoko Tsutsui, Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 79 ( 2 ) 196 - 201 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Permanent hearing impairment has a life-long impact on children and its early identification is important for language development. A newborn hearing screening (NHS) program has started in Okayama Prefecture, Japan, in 1999 to detect hearing impairment immediately after birth. We aim to examine the effect of this screening program on vocabulary development in pre-school children in a before and after comparative study design. METHODS: A total of 107 5-year-old children who graduated from Okayama Kanariya Gakuen (an auditory center for hearing-impaired children) between 1998 and 2011 were enrolled in this study. The pre-NHS group (n=40) was defined as those who graduated between 1998 and 2003, while the post-NHS group (n=67) was defined as those who graduated between 2004 and 2011. The primary outcome was receptive vocabulary, which was assessed by the Picture Vocabulary Test [score <18 (low) vs. score ≥18 (high)]. The secondary outcome was productive vocabulary, or the number of productive words, which was assessed by an original checklist [<1773 words (low) vs. ≥1773 (high)]. We calculated odds ratios and 95% confidence intervals for vocabulary development and compared both groups. RESULTS: The adjusted Picture Vocabulary Test score and number of productive words were significantly higher (p<0.01) in the post-NHS group than the pre-NHS group. Odds ratios were 2.63 (95% confidence interval: 1.17-5.89) for receptive vocabulary and 4.17 (95% confidence interval: 1.69-10.29) for productive vocabulary. CONCLUSIONS: The introduction of NHS in Okayama Prefecture significantly improved both receptive and productive vocabulary development in hearing-impaired children.

DOI： 10.1016/j.ijporl.2014.12.006

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2年以上聴力経過を観察した小児心因性難聴の7例

前田幸英, 片岡祐子, 菅谷明子, 長安吏江, 中川敦子, 假谷伸, 西﨑和則

AUDIOLOGY JAPAN 58 ( 5 ) 335 - 336 2015年

新生児聴覚スクリーニングとの関連について

片岡祐子

小児耳鼻咽喉科 36 ( 3 ) 321 - 325 2015年

記述言語：日本語出版者・発行元：日本小児耳鼻咽喉科学会

2014年に改訂された人工内耳適応基準では，小児の適応年齢は従来の 1 歳 6 カ月以上から，1 歳以上に引き下げられた。この適応基準改定の背景には，近年の研究から低年齢での人工内耳の有用性や手術の安全性が確立されたことはさることながら，新生児聴覚スクリーニングの普及も大きく貢献していると言える。<br/> 新生児聴覚スクリーニングにより早期の療育開始が可能となり，また早期に音声による言語情報が入力されることによりコミュニケーション能力が向上する確率は有意に高くなる。本邦でも2000年度よりモデル事業として新生児聴覚スクリーニングは開始され，以後全国的に拡大しているが，スクリーニング実施にはいまだ地域差が大きいのが実情であり，全例実施されている産科施設は約半数程度でしかない。新生児聴覚スクリーニングを受け，早期に精密検査，療育へと繋げられた児では，1 歳時点で難聴の程度を判断するのは困難ではなく，早期の人工内耳手術は可能である。新生児聴覚スクリーニングとその後の診断，療育体制の整備を行うことで，難聴児の音声によるコミュニケーション能力の向上を目指したい。

DOI： 10.11374/shonijibi.36.321

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その他リンク： http://search.jamas.or.jp/link/ui/2016123054

Outcomes of consonant-vowel monosyllable perception and word recognition after cochlear implantation in elderly Japanese patients. 国際誌

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

Acta oto-laryngologica 135 ( 11 ) 1108 - 12 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSION: Performance in consonant-vowel (CV) monosyllable speech perception after cochlear implantation (CI) in the elderly (≥ 65 years) is equivalent to that of young adults (18-64 years). Present data in the Japanese language supported the indication for CI in the elderly. Word recognition after CI was significantly lower in the elderly than young adults. OBJECTIVE: This study compared outcomes of monosyllable perception and word recognition after CI between elderly patients and young adults with post-lingual deafness. Age-related differences in CV monosyllable speech perception in Japanese were examined. METHODS: A retrospective chart review of 137 patients with post-lingual deafness who underwent CI at Okayama University Hospital during 1992-2014 [young adults aged 18-64 years (n = 96) and elderly aged ≥ 65 years (n = 41) at implantation] was conducted. CV monosyllable speech perception post-CI was compared among age groups (18-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89). CV monosyllable perception and word recognition scores post-CI were compared between the elderly and young adults. RESULTS: There was no significant difference in CV monosyllable speech perception among age groups. CV monosyllable speech perception in the elderly (61.4 ± 25.5%) did not differ from that of young adults (65.9 ± 24.8%). Word recognition scores were significantly lower in the elderly (64.3 ± 28.1%) than young adults (80.4 ± 25.9%) (p < 0.05).

DOI： 10.3109/00016489.2015.1062547

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[The age at which the grade of Special Child Dependent's Allowance Act can be judged in the case of deaf children].

Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 117 ( 9 ) 1200 - 4 2014年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The spread of neonatal hearing screening has made the identification of hearing loss in early childhood possible, and most of the children with hearing loss are diagnosed and provided with early intervention within several months after their birth. However, they have to wait to receive the Special Child Dependent's Allowance until their hearing levels are evaluated with audiometers. Under the Special Child Dependent's Allowance Act now in force, a delay of several years occurs for those children before they can receive the allowance after diagnosis. We retrospectively reviewed hearing test results of children who had not reacted at 90dBnHL bilaterally in ABR within 12 months after birth, and examined when those results were certain enough to determine their allowance eligibility. We found that the eligibility in children with hearing loss alone could be determined at 1 year of age; as for children who had other disorders, since it was mostly difficult to test them with an audiometer, the diagnosis of hearing loss must always be made carefully but it was also possible to determine the eligibility for the allowance at 1 year of age.

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難聴児に対する特別児童扶養手当等級判定時期に関する検討乳児期にABR90dBnHL無反応であった児の聴力経過より

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 9 ) 1200 - 1204 2014年9月

記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

近年新生児聴覚スクリーニングの普及により、難聴児の多くは生後数ヵ月のうちに診断され、療育を開始している。一方、特別児童扶養手当に関してはオージオメーターによる検査が可能となるまで受給されず、診断から受給までの間に年単位の時間差が生じているのが現状である。われわれは、生後12ヵ月までにABRを実施し、両耳90dBnHLで無反応であった児の聴力経過の検討を行った。その結果、聴覚障害単独の児では特別児童扶養手当に該当するか否かは1歳時点で可能であるが、等級の判定は1歳で慎重な判断が必要であること、また重複障害をもつ児は検査を繰り返し慎重に診断する必要があるが特別児童扶養手当の判定は可能であると判断した。(著者抄録)

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01099&link_issn=&doc_id=20141003450006&doc_link_id=1390282679988087552&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282679988087552&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

当科で経験したBOR症候群の2家族例

浦口健介, 菅谷明子, 片岡祐子, 前田幸英, 假谷伸, 福島邦博, 西崎和則

Otology Japan 24 ( 4 ) 548 - 548 2014年9月

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