研究者詳細 - 片岡　祐子

論文 - 片岡　祐子

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【てこずった症例・難治症例にどう対応するか】耳領域変動性一側性耳痛を主訴に受診した椎骨動脈解離症例

大道亮太郎, 片岡祐子

JOHNS 40 ( 9 ) 1005 - 1008 2024年9月

記述言語：日本語出版者・発行元：(株)東京医学社

＜文献概要＞はじめに日常診療を行っている中で耳痛を主訴に来院される患者は数多く存在する。耳痛を呈する疾患としては,通常中耳炎,外耳炎,耳性帯状疱疹などの細菌や真菌,ウイルスによる炎症性疾患が多い。その他には真珠腫性中耳炎やANCA関連血管炎性中耳炎などの中耳疾患や外耳道癌などの腫瘍性疾患など,内耳から外耳にかけての直接的な疾患の他に,耳周辺の他組織に原因がある上気道炎,扁桃炎,耳下腺炎,顎関節症,頸部リンパ節炎,茎状突起過長症などを考慮する。基質的疾患が見つからない場合には舌咽神経痛や三叉神経痛,後頭神経痛などの神経痛を考慮する。

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2024&ichushi_jid=J01814&link_issn=&doc_id=20240826030026&doc_link_id=10.24479%2Fohns.0000001236&url=https%3A%2F%2Fdoi.org%2F10.24479%2Fohns.0000001236&type=%E5%8C%BB%E6%9B%B8.jp_%E3%82%AA%E3%83%BC%E3%83%AB%E3%82%A2%E3%82%AF%E3%82%BB%E3%82%B9&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00024_2.gif

聴覚障がい児の新版K式発達検査2001の「了解」の正答率に関する検討

平岡東佳, 問田直美, 矢永美穂, 藤原真由美, 片岡祐子, 菅谷明子, 福田章一郎

Audiology Japan 67 ( 5 ) 394 - 394 2024年9月

Exploring factors influencing the hearing test and hearing aid adoption among Japanese older adults: Implications of recognizing the hearing loss-dementia relationship. 査読国際誌

Ichiro Fukumasu, Yuko Kataoka, Takahiro Tabuchi, Kentaro Egusa, Mizuo Ando

Auris, nasus, larynx 51 ( 4 ) 822 - 827 2024年8月

担当区分：責任著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: The hearing aid adoption rate among older adults in Japan is lower than that in other developed countries. Herein, a survey was conducted to identify this bottleneck and develop countermeasures. This study aimed to examine whether raising awareness of the relationship between hearing loss and dementia is significant for hearing tests and adopting hearing aids. METHODS: A questionnaire was administered to participants aged 65 or older who visited a general hospital to determine the background factors (1) for a recent history of hearing tests, (2) for the desire to visit an otolaryngologist and have a hearing test, (3) for recognizing the hearing loss-dementia relationship, and (4) for adopting hearing aids. RESULTS: A total of 517 patients (mean age, 78.06; SD 6.97), representing 2.4% of the region's older-adult population, participated in the survey. A history of hearing tests within five years was significantly associated with recognizing the hearing loss-dementia relationship (adjusted OR 2.36, 95% CI 1.49-3.72). The desire to visit an otolaryngologist or have a hearing test was significantly associated with recognizing the hearing loss-dementia relationship (adjusted OR 1.70, 95% CI 1.02-2.85). Moreover, 39.3% were aware of the hearing loss-dementia relationship. The significant associated factors were being female (OR 2.50, 95% CI 1.64-3.81) and having interpersonal hobbies (OR 1.66, 95% CI 1.11-2.49). The significant background factors for adopting hearing aids were older age (OR 6.95, 95% CI 1.90-25.40), self-reported severe hearing impairment (OR 5.49, 95% CI 2.55-11.80), and living alone (OR 2.63, 95% CI 1.18-5.89). Recognizing the hearing loss-dementia relationship was not a significant factor. CONCLUSION: Raising awareness of the hearing loss-dementia relationship was not associated with adopting hearing aids for self-reported hearing impairments. However, it may be associated with otolaryngology visits and hearing tests. Thus, steps like hearing screening for older adults are also essential.

DOI： 10.1016/j.anl.2024.07.001

Middle-Ear Salivary Gland Choristoma with Congenital, Single-Sided Hearing Loss. 査読

Yuichiro Tominaga, Akiko Sugaya, Shin Kariya, Aiko Shimizu, Yuko Kataoka, Mizuo Ando

Acta medica Okayama 78 ( 4 ) 349 - 355 2024年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Middle-ear salivary gland choristoma (SGCh) is a rare, benign tumor that causes conductive hearing loss owing to middle-ear morphological abnormalities. Early diagnosis is challenging, and surgical resection is indispensable for a definitive diagnosis. We report the case of a 3-year-old boy diagnosed with middle-ear SGCh during the follow-up period for left-sided hearing loss discovered at newborn hearing screening (NHS). Long-term follow-up after the NHS result, subsequent computed tomography/magnetic resonance imaging, and surgical resection led to its relatively early diagnosis and treatment.

DOI： 10.18926/AMO/67554

市民公開講座参加者における聴力像の実際

浜本真一, 假谷伸, 菅谷明子, 片岡祐子, 前田幸英, 大道亮太郎, 安藤瑞生, 原浩貴

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 4 ) 549 - 549 2024年4月

突発性難聴に対する二次治療としてステロイド鼓室内注入の予後因子に関する検討

小松原靖聡, 橘智靖, 假谷彰文, 片岡祐子, 安藤瑞生

日本耳鼻咽喉科頭頸部外科学会会報 127 ( 4 ) 525 - 525 2024年4月

聴覚障害者における災害時・緊急時の情報伝達の課題と解決に向けた取り組み査読

片岡祐子, 小林有美子, 野田夕月奈, 大守伊織, 牧尉太, 日吉顕太, 本多達也

日本災害医学会雑誌 29 ( 2 ) 124 - 130 2024年

聞き取り困難症-検出と対応のポイント-聞き取り困難症の対応 1)環境調整と聴覚トレーニング

片岡祐子

Monthly Book ENTONI ( 301 ) 2024年

Cochlear Implantation in the Poorer-Hearing Ear Is a Reasonable Choice. 査読

Ryotaro Omichi, Shin Kariya, Yukihide Maeda, Kunihiro Fukushima, Yuko Kataoka, Akiko Sugaya, Kazunori Nishizaki, Mizuo Ando

Acta medica Okayama 77 ( 6 ) 589 - 593 2023年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Choosing the optimal side for cochlear implantation (CI) remains a major challenge because of the lack of evidence. We investigated the choice of the surgery side for CI (i.e., the better- or poorer-hearing ear) in patients with asymmetric hearing. Audiological records of 74 adults with a unilateral hearing aid who had undergone surgery at Okayama University Hospital were reviewed. The definition of 'better-hearing ear' was the aided ear, and the unaided ear was considered the poorer-hearing ear. We performed a multiple regression analysis to identify potential predictors of speech recognition performance after unilateral CI in the patients. Fifty-two patients underwent CI in the poorer-hearing ear. The post-Ci bimodal hearing rate was far higher in the poorer-ear group (77.8% vs. 22.2%). A multivariate analysis revealed that prelingual hearing loss and the patient's age at CI significantly affected the speech recognition outcome (beta coefficients: 24.6 and -0.33, 95% confidence intervals [11.75-37.45] and [-0.58 to -0.09], respectively), but the CI surgery side did not (-6.76, [-14.92-1.39]). Unilateral CI in the poorer-hearing ear may therefore be a reasonable choice for adult patients with postlingual severe hearing loss, providing a greater opportunity for postoperative bimodal hearing.

DOI： 10.18926/AMO/66150

軽度・中等度難聴だからこそ気を付けること幼児・学童招待

片岡祐子

日本耳鼻咽喉科頭頸部外科学会会報 126 ( 11 ) 1185 - 1190 2023年11月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

新生児聴覚スクリーニング(NHS)が浸透し,先天性難聴児の診断から療育までは,1-3-6ルール,すなわち生後1ヵ月までにNHS,生後3ヵ月までに診断,生後6ヵ月までに補聴器装用と療育を開始するというタイムテーブルが標準化している.しかし一方で,軽度・中等度難聴児では補聴器装用開始時期や補聴器適応聴力に明確な基準がなく,診断や補聴導入の基準が不明確でその時期や必要性に迷うことが多い.その結果適切な補聴導入や療育を受けられていない児や,中途で医療機関を受診しなくなる児も散見される.軽度・中等度難聴の発達への影響に関しては個人差もあるが,放置することにより影響は大きくなるため,NHSで要精密検査であった児では,生後6ヵ月までには聴力レベルの診断を行うことを目指す.また補聴については,30dB以上であれば推奨されており,特に40dB以上は1-3-6ルールに準ずるとする見解が支持されている.軽度・中等度難聴では学齢期以降に補聴器装用を拒否する例も少数ではない.雑音下聴取も含めた語音明瞭度の評価や,学力,社会面も含めたアセスメントを行うこと,聴取の状況や補聴への意識を鑑み,課題を把握した上で,本人の意向も踏まえたカウンセリングと補聴導入を行うことが重要である.難聴児の抱える課題は個人差もあり,年齢とともに変化するため,長期にわたる伴走的支援を心掛けたい.(著者抄録)

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J07551&link_issn=&doc_id=20231201240001&doc_link_id=%2Fdz0tokei%2F2023%2F012611%2F001%2F1185-1190%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0tokei%2F2023%2F012611%2F001%2F1185-1190%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

聞き取り困難を呈する成人小児に対する聴覚情報処理検査の検出率 AMED研究からの報告

阪本浩一, 川瀬哲明, 岡本康秀, 片岡祐子, 土橋奈々, 中川尚志, 加我君孝, 小渕千絵, 坂本圭, 關戸智惠

Audiology Japan 66 ( 5 ) 405 - 405 2023年9月

APD/LiDの診断と支援招待査読

片岡祐子

Audiology Japan 66 ( 4 ) 230 - 236 2023年8月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(一社)日本聴覚医学会

聴覚情報処理障害(APD)/聞き取り困難(LiD)は,聴覚閾値は正常であるが中枢性聴覚情報処理が困難である状態で,騒音下や複数音声下の聞き取り困難を呈する。そのため,学校や社会生活の様々な場面において聴取および理解が難しく,コミュニケーションや学習,業務に支障を来すことが多い。APD/LiDの診断には,聴覚検査にて末梢性聴覚障害を除外し,聴覚情報処理検査(両耳分離聴検査,早口音声聴取検査,雑音下聴取検査等)を用いて行うが,質問紙での自覚的認知検査結果も参考にする。APD/LiDの介入と支援の方法は,音声入力情報の調整,環境調整,機器を用いた情報強化,トレーニングがある。音声入力情報の調整以外は,聴取の困難さに対するアプローチであるボトムアップ式と,内容を推測しやすくするアプローチであるトップダウン式の手段があり,各人の課題を分析した上で,必要な介入・支援方法を選定している。(著者抄録)

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2023&ichushi_jid=J00125&link_issn=&doc_id=20230901310002&doc_link_id=10.4295%2Faudiology.66.230&url=https%3A%2F%2Fdoi.org%2F10.4295%2Faudiology.66.230&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

【How to Follow-up-ハイリスク児フォローアップの必修知識2023】疾患別・領域別のフォローアップ退院時にみられる疾患・合併症のフォローアップ耳鼻科疾患難聴招待

片岡祐子

周産期医学 53 ( 4 ) 661 - 665 2023年4月

身体障害者に該当しない軽度・中等度難聴の補償と支援小児に対する補償と支援招待査読

片岡祐子

Audiology Japan 65 ( 6 ) 543 - 548 2022年12月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(一社)日本聴覚医学会

小児難聴のうち身体障害者に該当しない軽度・中等度難聴児は約60%を占める。近年新生児聴覚スクリーニングによる早期診断,療育開始や軽度・中等度難聴児補聴器助成事業導入といった社会的制度が拡充されてきた。軽度・中等度難聴児は一般的に聴取や言語発達が良好で,通常学校・級在籍児が多く,通級も含めて聴覚に関する特別支援教育を受ける児は少数である。しかし一方で,聴取能,言語発達遅滞や学力の低下,社会性の問題などが出現する頻度が高く,年齢が上がるにつれて顕著化,複雑化する傾向がある。インクルーシブ教育においては一見コミュニケーションに支障がなさそうであるが故,必ずしも適切な介入,教育者等による適切な理解と支援が受けられていないことが多い。通学校での合理的配慮や課題の把握を行うとともに,言語聴覚士や聴覚支援学校教師等による専門的検査や指導を併用できるよう,連携した支援体制の構築,情報共有が望まれる。(著者抄録)

その他リンク： https://search.jamas.or.jp/default/link?pub_year=2022&ichushi_jid=J00125&link_issn=&doc_id=20221229440003&doc_link_id=10.4295%2Faudiology.65.543&url=https%3A%2F%2Fdoi.org%2F10.4295%2Faudiology.65.543&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_3.gif

小児難聴と人工聴覚器

假谷伸、菅谷明子、片岡祐子

耳鼻咽喉科 2 ( 2 ) 263 - 269 2022年8月

小児難聴と人工聴覚器

假谷伸, 菅谷明子, 片岡祐子

耳鼻咽喉科 2 ( 2 ) 263 - 269 2022年8月

【先天性難聴への対応】補聴器・人工内耳を装用する小・中・高校生への総合的配慮

片岡祐子

JOHNS 38 ( 7 ) 775 - 778 2022年7月

【先天性難聴への対応】補聴器・人工内耳を装用する小・中・高校生への総合的配慮招待

片岡祐子

JOHNS 38 ( 7 ) 775 - 778 2022年7月

聴覚検査　聴性定常反応(ASSR)

片岡祐子

耳鼻咽喉科・頭頸部外科 94 ( 5 ) 54 - 59 2022年4月

Detailed clinical features and genotype-phenotype correlation in an OTOF-related hearing loss cohort in Japan. 査読国際誌

Yoh-Ichiro Iwasa, Shin-Ya Nishio, Hidekane Yoshimura, Akiko Sugaya, Yuko Kataoka, Yukihide Maeda, Yukihiko Kanda, Kyoko Nagai, Yasushi Naito, Hiroshi Yamazaki, Tetsuo Ikezono, Han Matsuda, Masako Nakai, Risa Tona, Yuika Sakurai, Remi Motegi, Hidehiko Takeda, Marina Kobayashi, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Sakiko Furutate, Shin-Ichiro Oka, Toshinori Kubota, Yasuhiro Arai, Yumiko Kobayashi, Daisuke Kikuchi, Tomoko Shintani, Noriko Ogasawara, Yohei Honkura, Shuji Izumi, Misako Hyogo, Yuzuru Ninoyu, Mayumi Suematsu, Jun Nakayama, Nana Tsuchihashi, Mayuri Okami, Hideaki Sakata, Hiroshi Yoshihashi, Taisuke Kobayashi, Kozo Kumakawa, Tadao Yoshida, Tomoko Esaki, Shin-Ichi Usami

Human genetics 141 ( 3-4 ) 865 - 875 2022年4月

記述言語：英語掲載種別：研究論文（学術雑誌）

Mutations in the OTOF gene are a common cause of hereditary hearing loss and the main cause of auditory neuropathy spectrum disorder (ANSD). Although it is reported that most of the patients with OTOF mutations have stable, congenital or prelingual onset severe-to-profound hearing loss, some patients show atypical clinical phenotypes, and the genotype-phenotype correlation in patients with OTOF mutations is not yet fully understood. In this study, we aimed to reveal detailed clinical characteristics of OTOF-related hearing loss patients and the genotype-phenotype correlation. Detailed clinical information was available for 64 patients in our database who were diagnosed with OTOF-related hearing loss. As reported previously, most of the patients (90.6%) showed a "typical" phenotype; prelingual and severe-to-profound hearing loss. Forty-seven patients (73.4%) underwent cochlear implantation surgery and showed successful outcomes; approximately 85-90% of the patients showed a hearing level of 20-39 dB with cochlear implant and a Categories of Auditory Performance (CAP) scale level 6 or better. Although truncating mutations and p.Arg1939Gln were clearly related to severe phenotype, almost half of the patients with one or more non-truncating mutations showed mild-to-moderate hearing loss. Notably, patients with p.His513Arg, p.Ile1573Thr and p.Glu1910Lys showed "true" auditory neuropathy-like clinical characteristics. In this study, we have clarified genotype-phenotype correlation and efficacy of cochlear implantation for OTOF-related hearing loss patients in the biggest cohort studied to date. We believe that the clinical characteristics and genotype-phenotype correlation found in this study will support preoperative counseling and appropriate intervention for OTOF-related hearing loss patients.

DOI： 10.1007/s00439-021-02351-7

【結果の読み方がよくわかる! 耳鼻咽喉科検査ガイド】聴覚検査聴性定常反応(ASSR) 招待

片岡祐子

耳鼻咽喉科・頭頸部外科 94 ( 5 ) 54 - 59 2022年4月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(株)医学書院

＜文献概要＞POINT ◆聴性定常反応(ASSR)は他覚的に聴覚閾値を測定する検査法で,周波数特異性に優れている.◆乳幼児,知的障害や認知機能低下者,機能性難聴者など,純音聴力検査の信頼性が低い者の聴力評価に有用である.

The fine-needle aspiration cytology and clinical findings of Kikuchi-Fujimoto disease in pediatric patients: a retrospective clinical study. 査読国際誌

Yuto Naoi, Tomoyasu Tachibana, Yoji Wani, Machiko Hotta, Katsuya Haruna, Yasutoshi Komatsubara, Kazunori Kuroda, Soichiro Fushimi, Tami Nagatani, Yuko Kataoka, Kazunori Nishizaki, Yasuharu Sato, Mizuo Ando

Acta oto-laryngologica 142 ( 3-4 ) 340 - 344 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Histological evaluation of lymph node is crucial for the definitive diagnosis of Kikuchi-Fujimoto disease (KFD). However, lymph node biopsy under local anesthesia is often difficult in pediatric patients. OBJECTIVES: We evaluated cytological findings for pediatric patients with prolonged cervical lymphadenitis clinically suggestive of KFD and investigated the clinical characteristics of patients diagnosed with KFD by fine-needle aspiration cytology (FNAC). METHODS: This retrospective clinical study included 58 Japanese pediatric patients with cervical lymphadenitis who underwent FNAC. RESULTS: Cytological diagnosis was KFD for 22 and suspicion of KFD for 11 patients. The remaining 25 patients were diagnosed with non-specific lymphadenitis (NSL). Tenderness was independently associated with a higher frequency of both KFD in narrow and broad senses, compared with NSL (p = .009; p = .038). The percentage of patients who underwent FNAC within 28 days from symptom onset tended to be higher among patients with KFD in a narrow sense than those with NSL (p = .052). CONCLUSION: This study indicated that the period from symptom onset to FNAC (<28 days) and the symptom of tenderness were associated with the cytological diagnosis of KFD.

DOI： 10.1080/00016489.2022.2040744

小児、思春期・若年がん患者に対する妊孕性温存療法　現状と改善の取り組み査読

秋定直樹，牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2021年12月

難聴児に対する補聴の有用性と限界　医療と療育・教育連携の必要性

片岡祐子

小児耳鼻咽喉科 42 ( 3 ) 258 - 262 2021年12月

創部感染の制御が可能であった人工内耳植え込み術後の小児の1例査読

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸, 安藤瑞生

日本耳鼻咽喉科免疫アレルギー感染症学会誌 1 ( 3 ) 177 - 180 2021年12月

難聴児に対する医療・教育連携に向けた取り組み　教師対象パンフレットの作成

片岡祐子

日本耳鼻咽喉科頭頸部外科学会会報 124 ( 12 ) 1590 - 1593 2021年12月

難聴児に対する補聴の有用性と限界医療と療育・教育連携の必要性査読

片岡祐子

小児耳鼻咽喉科 42 ( 3 ) 258 - 262 2021年12月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本小児耳鼻咽喉科学会

先天性難聴の早期発見,補聴器・人工内耳装用に伴い,難聴児の聴取能や言語発達は向上し,近年インクルーシブ教育を受ける児が増加している。しかしながら難聴児の聴取は補聴器や人工内耳を装用していても正常聴力児と同等ではなく,言語発達や学習面,友人関係,行動面で問題が生じることは多い。また新型コロナウイルス感染症拡大予防策のマスク着用やソーシャルディスタンスにより難聴児の聴取や読話は困難となり,コミュニケーションにおける支障は増大している。しかしながら,特にインクルーシブ教育を受けている児では,聴取の困難さや抱えている問題を担任教師が正確には把握ができていない場合が多い。学校生活において適切な配慮や支援が受けられるよう情報提供が必要であると考え,当院では教師対象パンフレットを作成している。学齢期の難聴児の多岐にわたる問題に対し,医療,療育・教育,行政等多職種で連携して支援する体制の構築が必要である。(著者抄録)

小児、思春期・若年がん患者に対する妊孕性温存療法現状と改善の取り組み査読

秋定直樹, 牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2021年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：耳鼻咽喉科臨床学会

当科で化学療法を施行した小児、思春期・若年(CAYA)世代がん患者20例を対象に、妊孕性温存に関する説明の実態調査を行った。その結果、妊孕性低下・消失について説明していた患者は2例のみであり、それぞれ17歳と23歳の未婚若年女性であった。一方、その他の女性5例(30歳台)や男性(13〜38歳)には説明が行われていなかった。また、妊孕性温存ガイドラインが出版された2017年の前後で妊孕性低下・消失について説明を実施した割合には著しい変化はみられず、妊孕性に対する配慮は担当医レベル、診療科レベルでも改善できる余地が十分にあると考えられた。

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00580&link_issn=&doc_id=20211209280011&doc_link_id=10.5631%2Fjibirin.114.957&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.114.957&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

難聴児に対する医療・教育連携に向けた取り組み教師対象パンフレットの作成査読

片岡祐子

日本耳鼻咽喉科頭頸部外科学会会報 124 ( 12 ) 1590 - 1593 2021年12月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

難聴児の早期発見・療育,人工内耳装用に伴い,聴取能や言語発達は向上している.加えて,障害児の共生に向けた社会的体制の変化も伴い,近年地域の学校でインクルーシブ教育を受ける児は増加している.しかし,難聴児の聴取は補聴器や人工内耳を装用しても正常聴力児と同等ではなく,大勢でさまざまな方向からの聴取を要する学校生活の環境において多くの場面で支障がある.また学年が上がるとともに学習面の限界や学力低下,友人との関係性の問題などが出現する頻度が高く,留意や配慮を要する.加えて,新型コロナウイルス感染症拡大予防策のマスク着用やソーシャルディスタンスにより,さらにコミュニケーションの支障は増大している.しかしながら,担任教師であってもそれらの問題を正確には把握しにくく,適切な配慮や支援が施されないことが多い.われわれはこれまでに実施した難聴児・者への質問紙による調査結果をもとに,難聴児の直面している問題と支援について教師が実際に活用しやすい形式でまとめたパンフレット「難聴をもつ小・中・高校生の学校生活で大切なこと先生編」を作成した.難聴児の抱える問題は成長の段階で変化するため,乳幼児期の補聴機器のフィッティングや言語訓練を中心とした指導で完結すべきではなく,学齢に達しても専門的支援を継続する必要がある.本冊子が難聴児の育成の一助となることに期待するとともに,今後学齢期以降の支援を充実させるよう努めたい.(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J07551&link_issn=&doc_id=20211224180007&doc_link_id=%2Fdz0tokei%2F2021%2F012412%2F007%2F1590-1593%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Fdz0tokei%2F2021%2F012412%2F007%2F1590-1593%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

創部感染の制御が可能であった人工内耳植え込み術後の小児の1例査読

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸, 安藤瑞生

日本耳鼻咽喉科免疫アレルギー感染症学会誌 1 ( 3 ) 177 - 180 2021年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本耳鼻咽喉科免疫アレルギー感染症学会

1日2回の生理食塩水洗浄と抗菌薬の保存的加療により、人工内耳植え込み術後の局所感染を制御できた小児の1例(1歳11ヵ月男児)について報告した。本症例で術後創部感染の保存的加療が可能であった要因として、「起炎菌がMRSAなどではなく、MSSAであったこと」「鼓膜所見や起炎菌から、中耳からの感染ではなく、皮膚からの感染であったため」「当院では、人工内耳植え込み術の際、minimum invasive surgeryを行っていること」が考えられた。

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J07545&link_issn=&doc_id=20220120310010&doc_link_id=%2Ffm9areka%2F2021%2F000103%2F010%2F0177-0180%26dl%3D0&url=https%3A%2F%2Fwww.medicalonline.jp%2Fjamas.php%3FGoodsID%3D%2Ffm9areka%2F2021%2F000103%2F010%2F0177-0180%26dl%3D0&type=MedicalOnline&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00004_2.gif

Apocrine Hidrocystoma of the External Auditory Canal in a Child. 査読国際誌

Tomoyasu Tachibana, Tomoaki Sasaki, Yoji Wani, Yuto Naoi, Yuko Kataoka, Kazunori Nishizaki, Mizuo Ando

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 42 ( 8 ) e1181-e1183 2021年9月

Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss. 査読

Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

Acta medica Okayama 75 ( 4 ) 511 - 516 2021年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

DOI： 10.18926/AMO/62404

Hypertrophic rhinitis without sinusitis histologically compatible with IgG4-related disease 査読

Maki Akamatsu, Aiko Oka, Shinya Okada, Shogo Oyamada, Koichi Hirose, Shin Kariya, Yuko Kataoka, Kazunori Nishizaki, Kengo Kanai, Yoshihiro Noguchi, Mitsuhiro Okano

Otolaryngology Case Reports 19 100294 - 100294 2021年6月

Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion. 査読国際誌

Tomoyasu Tachibana, Shin Kariya, Yoji Wani, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Kuroda, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Takuma Makino, Yuko Kataoka, Kazunori Nishizaki

Auris, nasus, larynx 48 ( 1 ) 154 - 160 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

DOI： 10.1016/j.anl.2020.07.017

両側難聴児・者が学校生活で抱える問題に関する調査の検討査読

片岡祐子, 菅谷明子, 中川敦子, 田中里実, 問田直美, 福島邦博, 前田幸英, 假谷伸

Audiology Japan 64 ( 1 ) 2021年

軽度~中等度難聴児への対応と課題思春期に学校生活で抱える問題招待

片岡祐子

小児耳鼻咽喉科 42 ( 1 ) 57 - 62 2021年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本小児耳鼻咽喉科学会

小児難聴の中で身体障害者に該当しない軽度・中等度難聴児は約30%を占める。2010年から導入された軽度・中等度難聴児への補聴器購入助成制度は現在すべての都道府県で実施され,その恩恵により補聴器を購入する児は増加している。ただし補聴器を装用しても正常聴力児と同等の聴取が可能なわけではなく,インクルーシブ教育を受ける中で問題に直面する児は多い。その問題は言語発達遅滞や学力の低下,友人とのコミュニケーション,心理面など多岐にわたり,年齢が上がるにつれて顕著化,複雑化する。それらの課題に対して,聴取の環境調整や視覚情報の提示,教育面,心理・社会面も踏まえて個別に介入や支援を行うこと,教育者や周囲の理解を啓蒙することが必要である。難聴児が成長し社会参加をするに当たり必要なセルフアドボカシースキルを確立できるような指導や支援を行うべきある。(著者抄録)

Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. 査読国際誌

Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 138 110298 - 110298 2020年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

DOI： 10.1016/j.ijporl.2020.110298

Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. 査読国際誌

Yasutoshi Komatsubara, Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Kazunori Kuroda, Yuto Naoi, Yuko Kataoka, Yasuharu Sato, Shin Kariya, Kazunori Nishizaki

Acta oto-laryngologica 140 ( 9 ) 773 - 778 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

DOI： 10.1080/00016489.2020.1767303

Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media. 査読国際誌

Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Seiichiro Makihara, Jun Nishihira, Tomoyasu Tachibana, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 41 ( 3 ) 364 - 370 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

HYPOTHESIS: Macrophage migration inhibitory factor plays an important role in the expression of interleukin (IL)-1β and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in lipopolysaccharide-induced otitis media. BACKGROUND: NLRP3 inflammasome and macrophage migration inhibitory factor are critical molecules mediating inflammation. However, the interaction between the NLRP3 inflammasome and macrophage migration inhibitory factor has not been fully examined. METHODS: Wild-type mice and macrophage migration inhibitory factor gene-deficient (MIF) mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 hours after the injection. Concentrations of IL-1β, NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: In the immunohistochemical study using the wild-type mice, positive staining of macrophage migration inhibitory factor, NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear. The number of inflammatory cells caused by lipopolysaccharide administration decreased remarkably in the MIF mice as compared with the wild-type mice. The concentrations of IL-1β, NLRP3, ASC, and caspase-1 increased in the lipopolysaccharide-treated wild-type mice. The MIF mice with lipopolysaccharide had decreased levels of IL-1β, NLRP3, ASC, and caspase-1 as compared with the wild-type mice. CONCLUSION: Macrophage migration inhibitory factor has an important role in the production of IL-1β and the NLRP3 inflammasome. Controlling the inflammation by modulating macrophage migration inhibitory factor and the NLRP3 inflammasome may be a novel therapeutic strategy for otitis media.

DOI： 10.1097/MAO.0000000000002537

「軽度~中等度難聴児への対応と課題」思春期に学校生活で抱える問題

片岡祐子

小児耳鼻咽喉科 41 ( 2 ) 2020年

課題山積のわが国の乳幼児健診先天性聴覚障害

片岡祐子

日本医師会雑誌 149 ( 4 ) 2020年

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究インクルーシブ教育を受ける思春期の難聴者の抱える問題に関する研究

西崎和則, 片岡祐子, 菅谷明子

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究令和元年度総括・分担研究報告書(Web) 2020年

Progression of hearing loss and choice of hearing aids by patients in their 60s, 70s, and 80s and older: experience in the Japanese super-aged era. 査読国際誌

Yukihide Maeda, Shin Kariya, Shohei Fujimoto, Akiko Sugaya, Yuko Kataoka, Atsuko Nakagawa, Satomi Tanaka, Natsumi Hosokawa, Kazunori Nishizaki

Acta oto-laryngologica 139 ( 12 ) 1077 - 1082 2019年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Demographic data of patients with sensorineural hearing loss (SNHL) in super-aged societies are still limited.Aims/objectives: To report audiometric statistics of SNHL and hearing aid (HA) use in patients in their 60s, 70s, and 80s and older during the super-aged era.Material and methods: Medical charts and audiograms of 2064 older patients with SNHL who visited a Japanese University Hospital in 2007-2018 were retrospectively reviewed. Among 270 patients referred to the HA service unit (HASU), the percentage of final decisions to continue using HAs was calculated.Results: The average pure tone thresholds on initial visit to the clinic were 56.9, 60.6, 69.4, and 82.4 dB HL in patients in their 60s, 70s, 80s, and 90s, respectively. The rates of progression were 0.25, 0.87, 1.19, and 1.37 dB/year in patients in their 50s, 60s, 70s, and 80s, respectively. The percentage of patients in HASU who chose to use HAs did not differ among the 60s (59.3%), 70s (51.2%), and 80s and older (58.2%).Conclusions and significance: The clinical picture of patients with SNHL in their 70s and 80s differs because progression accelerates exponentially through these ages. HAs can be recommended to older adult patients in all the age groups.

DOI： 10.1080/00016489.2019.1667531

Impact of reading and writing skills on academic achievement among school-aged hearing-impaired children. 査読国際誌

Akiko Sugaya, Kunihiro Fukushima, Soshi Takao, Norio Kasai, Yukihide Maeda, Akie Fujiyoshi, Yuko Kataoka, Shin Kariya, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 126 109619 - 109619 2019年11月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Reading and writing skills are important for hearing-impaired children since these skills help them to develop their language skills, but the prevalence of reading/writing difficulties and its effects on language development aspects among them are unclear. In this study, we identified language development features and demographic factors of Japanese hearing-impaired children diagnosed as having reading/writing difficulties. METHODS: We analyzed data from a total of 546 sever-to-profound pre-school and elementary school hearing-impaired children for this study. Children with reading/writing difficulties (Group A) were defined as children obtaining low scores (-1.5 SD compared to others in the same grade) in the Screening Test of Reading and Writing for Japanese Primary School Children (STRAW), and we compared other language development features (communication ability, vocabulary, syntax and academic achievement) and demographic factors to those of hearing-impaired children with normal reading and writing skills (Group B). We assessed language development domains as outcomes using the Assessment of Language Development for Japanese Children (ALADJIN) package, and analyzed the results stratified by age groups (5-6, 7-8, 9-10, and 11-12 years) using multiple regression analyses. RESULTS: The prevalence of reading/writing difficulties was 20.1% among the participants. Almost all point estimates in each language development domain showed better odds ratios (OR) except Criterion Referenced Test -II (CRT-II) mathematics in 11- to 12-year-olds in fully-adjusted models. Among 9- to 10-year-olds, the ORs (95% confidence interval) for fair academic achievement measured by CRT-II were 2.60 (1.09-6.20) for Japanese and 3.02 (1.29-7.11) for mathematics in Group B, even after adjusting for possible confounding factors. CONCLUSIONS: Reading and writing are important for language development of hearing-impaired children, especially for academic achievement during the middle phase of elementary school. Screening for reading/writing difficulties is important for appropriate intervention and to prevent language and academic delays among hearing-impaired children.

DOI： 10.1016/j.ijporl.2019.109619

Comprehensive analysis of syndromic hearing loss patients in Japan. 査読国際誌

Michie Ideura, Shin-Ya Nishio, Hideaki Moteki, Yutaka Takumi, Maiko Miyagawa, Teruyuki Sato, Yumiko Kobayashi, Kenji Ohyama, Kiyoshi Oda, Takamichi Matsui, Tsukasa Ito, Hiroshi Suzumura, Kyoko Nagai, Shuji Izumi, Nobuhiro Nishiyama, Manabu Komori, Kozo Kumakawa, Hidehiko Takeda, Yoko Kishimoto, Satoshi Iwasaki, Sakiko Furutate, Kotaro Ishikawa, Masato Fujioka, Hiroshi Nakanishi, Jun Nakayama, Rie Horie, Yumi Ohta, Yasushi Naito, Mariko Kakudo, Hirofumi Sakaguchi, Yuko Kataoka, Kazuma Sugahara, Naohito Hato, Takashi Nakagawa, Nana Tsuchihashi, Yukihiko Kanda, Chiharu Kihara, Tetsuya Tono, Ikuyo Miyanohara, Akira Ganaha, Shin-Ichi Usami

Scientific reports 9 ( 1 ) 11976 - 11976 2019年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

More than 400 syndromes associated with hearing loss and other symptoms have been described, corresponding to 30% of cases of hereditary hearing loss. In this study we aimed to clarify the mutation spectrum of syndromic hearing loss patients in Japan by using next-generation sequencing analysis with a multiple syndromic targeted resequencing panel (36 target genes). We analyzed single nucleotide variants, small insertions, deletions and copy number variations in the target genes. We enrolled 140 patients with any of 14 syndromes (BOR syndrome, Waardenburg syndrome, osteogenesis imperfecta, spondyloepiphyseal dysplasia congenita, Stickler syndrome, CHARGE syndrome, Jervell and Lange-Nielsen syndrome, Pendred syndrome, Klippel-Feil syndrome, Alport syndrome, Norrie disease, Treacher-Collins syndrome, Perrault syndrome and auditory neuropathy with optic atrophy) and identified the causative variants in 56% of the patients. This analysis could identify the causative variants in syndromic hearing loss patients in a short time with a high diagnostic rate. In addition, it was useful for the analysis of the cases who only partially fulfilled the diagnostic criteria.

DOI： 10.1038/s41598-019-47141-4

OTOF mutation analysis with massively parallel DNA sequencing in 2,265 Japanese sensorineural hearing loss patients. 査読国際誌

Yoh-Ichiro Iwasa, Shin-Ya Nishio, Akiko Sugaya, Yuko Kataoka, Yukihiko Kanda, Mirei Taniguchi, Kyoko Nagai, Yasushi Naito, Tetsuo Ikezono, Rie Horie, Yuika Sakurai, Rina Matsuoka, Hidehiko Takeda, Satoko Abe, Chiharu Kihara, Takashi Ishino, Shin-Ya Morita, Satoshi Iwasaki, Masahiro Takahashi, Tsukasa Ito, Yasuhiro Arai, Shin-Ichi Usami

PloS one 14 ( 5 ) e0215932 2019年

記述言語：英語掲載種別：研究論文（学術雑誌）

The OTOF gene (Locus: DFNB9), encoding otoferlin, is reported to be one of the major causes of non-syndromic recessive sensorineural hearing loss, and is also reported to be the most common cause of non-syndromic recessive auditory neuropathy spectrum disorder (ANSD). In the present study, we performed OTOF mutation analysis using massively parallel DNA sequencing (MPS). The purpose of this study was to reveal the frequency and precise genetic and clinical background of OTOF-related hearing loss in a large hearing loss population. A total of 2,265 Japanese sensorineural hearing loss (SNHL) patients compatible with autosomal recessive inheritance (including sporadic cases) from 53 otorhinolaryngology departments nationwide participated in this study. The mutation analysis of 68 genes, including the OTOF gene, reported to cause non-syndromic hearing loss was performed using MPS. Thirty-nine out of the 2,265 patients (1.72%) carried homozygous or compound heterozygous mutations in the OTOF gene. It is assumed that the frequency of hearing loss associated with OTOF mutations is about 1.72% of autosomal recessive or sporadic SNHL cases. Hearing level information was available for 32 of 39 patients with biallelic OTOF mutations; 24 of them (75.0%) showed profound hearing loss, 7 (21.9%) showed severe hearing loss and 1 (3.1%) showed mild hearing loss. The hearing level of patients with biallelic OTOF mutations in this study was mostly severe to profound, which is consistent with the results of past reports. Eleven of the 39 patients with biallelic OTOF mutations had been diagnosed with ANSD. The genetic diagnosis of OTOF mutations has significant benefits in terms of clinical decision-making. Patients with OTOF mutations would be good candidates for cochlear implantation; therefore, the detection of OTOF mutations is quite beneficial for patients, especially for those with ANSD.

DOI： 10.1371/journal.pone.0215932

小児科医に求められる新生児医療の基本新生児室で行われる検査の意義と実際新生児聴覚スクリーニング

片岡祐子

小児内科 51 ( 5 ) 2019年

難治性聴覚障害に関する調査研究当科で経験したWFS1遺伝子変異による若年発症型両側性感音難聴の2家系例

西崎和則, 片岡祐子, 前田幸英, 菅谷明子

難治性聴覚障害に関する調査研究平成30年度総括・分担研究報告書(Web) 2019年

「新生児聴覚スクリーニングがもたらすもの」

片岡祐子

三重医報 ( 709 ) 2019年

乳幼児滲出性中耳炎診断における 1,000Hz ティンパノメトリーの有用性の検討

片岡祐子, 前田幸英, 藤澤郁, 菅谷明子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 122 ( 7 ) 2019年

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究「遅発性難聴の早期発見」「思春期の難聴児が抱える問題の検証」に関する研究

西崎和則, 片岡祐子, 菅谷明子

身体的・精神的・社会的(biopsychosocial)に健やかな子どもの発育を促すための切れ目のない保健・医療体制提供のための研究平成30年度総括・分担研究報告書(Web) 2019年

新生児聴覚スクリーニングの現状と今後の課題

片岡祐子

日本耳鼻咽喉科学会会報 122 ( 12 ) 2019年

NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. 国際誌

Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Yohei Noda, Seiichiro Makihara, Kazunori Nishizaki

Acta oto-laryngologica 138 ( 12 ) 1061 - 1065 2018年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is a critical molecule mediating interleukin-1β (IL-1β) responses. However, the role of the NLRP3 inflammasome in otitis media has not been fully examined. AIMS/OBJECTIVES: The purpose of this study is to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in lipopolysaccharide-induced otitis media. MATERIALS AND METHODS: BALB/c mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 h after injection. Concentrations of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: The transtympanic injection of lipopolysaccharide significantly upregulated levels of IL-1β, NLRP3, ASC, and caspase-1 in the middle ear as compared with the control mice. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear cavity. CONCLUSIONS AND SIGNIFICANCE: Lipopolysaccharide induces NLRP3 inflammasome components in the middle ear. The NLRP3 inflammasome may play an important role in the pathogenesis of otitis media. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for otitis media.

DOI： 10.1080/00016489.2018.1515499

Relationship between pure-tone audiogram findings and speech perception among older Japanese persons. 国際誌

Yukihide Maeda, Soshi Takao, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Satomi Tanaka, Rie Nagayasu, Atsuko Nakagawa, Kazunori Nishizaki

Acta oto-laryngologica 138 ( 2 ) 140 - 144 2018年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: To clarify how the pure-tone threshold (PTT) on the PTA predicts speech perception (SP) in elderly Japanese persons. METHODS: Data on PTT and SP were cross-sectionally analyzed in Japanese persons (656 ears in 353 patients, aged ≥65 years). Correlations of SP and average PTT in all tested frequencies were evaluated by Pearson's correlation coefficient and simple linear regression. After adjusting for sex, laterality of ears, and age, the relationship of average and frequency-specific PTT with impaired SP ≤50% was estimated by logistic regression models. RESULTS: SP correlated well (r = -0.699) with the average PTT of all tested frequencies. On the other hand, the correlation between patient age and SP was weak, especially among ≤85-year-old persons (r = -0.092). Linear regression showed that the average PTT corresponding to SP of 50% was 76.4 dB nHL. Odds ratios for impaired SP were highest for PTT at 2000 Hz. Odds ratios were higher for middle (500, 1000, 2000 Hz) and high frequencies (4000, 8000 Hz) than low frequencies (125, 250 Hz). CONCLUSION: The PTT on the pure-tone audiogram (PTA) is a good predictor of SP by speech audiometry among older persons, which could provide clinically important information for hearing aid fitting and cochlear implantation.

DOI： 10.1080/00016489.2017.1378435

次世代シークエンサーを併用した難聴の遺伝学的検査が有用であった小児難聴の3例

菅谷明子, 菅谷明子, 片岡祐子, 片岡祐子, 峠和美, 假谷伸, 前田幸英, 大道亮太郎, 佐藤吏江, 西崎和則

日本遺伝カウンセリング学会誌 39 ( 3 ) 2018年

ビスホスホネート製剤投与が原因と考えられた外耳道骨壊死

片岡祐子, 野田実里, 大道亮太郎, 清水藍子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 7 ) 2018年

骨吸収抑制薬関連顎骨壊死

片岡祐子

岡山医学会雑誌 130 ( 2 ) 2018年

How to Follow-up Q&A-2018アップデート予後聴力のフォローアップ:スクリーニングと聴覚予後

御牧信義, 片岡祐子

周産期医学 48 ( 9 ) 2018年

新生児聴覚スクリーニングの費用対効果の検討

片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 121 ( 10 ) 2018年

[Genetic Counseling of a Hearing-impaired Patient with Multiple Genetic Mutations].

Yuko Kataoka, Akiko Sugaya, Yukihide Maeda, Shin Kariya, Ryotaro Omichi, Kunihiro Fukushima, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 120 ( 2 ) 131 - 6 2017年2月

記述言語：日本語掲載種別：研究論文（学術雑誌）

Since April 2012, genetic testing for congenital hearing loss is covered by the public health insurance in Japan. Recent (since August 2015) developments in next-generation sequencing technology have enabled the detection of 154 mutations in 19 genes. Genetic testing provides valuable information on hearing phenotype, prognosis, and prediction of associated symptoms. We report a hearing-impaired patient in whom multiple genetic mutations were detected. This patient carries two missense mutations in GJB2 (p.G45E, p.Y136X), as well as a mitochondrial mutation (7445A>G). Since the number of genes detectable by genetic testing has increased, the diagnosis of hearing loss can be made with greater accuracy. However, it is often difficult to clinically understand and interpret the genotype information, especially when multiple gene variants are detected in one patient or family. Genetic counseling plays an important part in the intervention for or follow-up of such patients. Genotypic and phenotypic information of other family members is necessary, so that both the patient and the family can understand and accept the results of genetic testing.

複数の遺伝子ヴァリアントを有する難聴者における遺伝カウンセリング経験

片岡祐子, 菅谷明子, 前田幸英, 假谷伸, 大道亮太郎, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 2 ) 2017年

MRI 検査後に人工内耳インプラント磁石の反転を来した2症例

片岡祐子, 内藤智之, 假谷伸, 菅谷明子, 前田幸英, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 120 ( 5 ) 2017年

Characteristics of audiogram configuration in multiple-system atrophy C and cortical cerebellar atrophy. 国際誌

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Rie Nagayasu, Atsuko Nakagawa, Toru Yamashita, Koji Abe, Kazunori Nishizaki

Acta oto-laryngologica 136 ( 3 ) 266 - 70 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSION: The prevalence of low-tone hearing loss (LTHL) is significantly high in spinocerebellar degeneration (SCD) with cerebellar predominance, including multiple-system atrophy C (MSA-C) and cortical cerebellar atrophy (CCA). OBJECTIVE: This study aimed to test the hypothesis that SCD with cerebellar predominance, MSA-C and CCA may cause auditory symptoms. METHODS: The shape and threshold of pure-tone audiograms were evaluated for MSA-C (n = 47; mean (± SD) age, 61.6 ± 8.9 years), CCA (n = 16; 62.8 ± 9.5 years), and age-matched controls (n = 169; 62.5 ± 10.7 years). To differentiate specific hearing loss for MSA-C and CCA from presbycusis, the shape of audiograms was examined based on previously established audiological criteria. RESULTS: When audiogram shape was defined according to audiological criteria, the odds ratio for LTHL in SCD compared to controls was 2.492 (95% confidence interval (CI) = 1.208-5.139; p < 0.05, Pearson's Chi-square test) in MSA-C and 2.194 (95% CI = 0.709-6.795) in CCA. When the selection of audiogram shape according to these criteria was verified by three certified audiologists, odds ratios for LTHL in MSA-C and CCA were 3.243 (95% CI = 1.320-7.969) and 3.692 (95% CI = 1.052-12.957), respectively, significantly higher than in controls.

DOI： 10.3109/00016489.2015.1104722

当科における小児両側人工内耳50例の検討

長安吏江, 菅谷明子, 假谷伸, 福島邦博, 福島邦博, 片岡祐子, 前田幸英, 大道亮太郎, 西崎和則

小児耳鼻咽喉科 37 ( 1 ) 2016年

海水浴後に罹患したShewanella putrefaciensによる中耳感染症の例

藤本将平, 片岡祐子, 假谷伸, 菅谷明子, 西崎和則

日本耳鼻咽喉科感染症・エアロゾル学会会誌 4 ( 1 ) 2016年

人工内耳装用児のスポーツに関するアンケート調査

片岡祐子, 菅谷明子, 假谷伸, 大道亮太郎, 前田幸英, 福島邦博, 西崎和則

Otology Japan 26 ( 3 ) 2016年

Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. 国際誌

Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yuko Kataoka, Junko Yoshinobu, Yukihide Maeda, Hisashi Ishihara, Takaya Higaki, Kazunori Nishizaki

Acta oto-laryngologica 136 ( 2 ) 136 - 40 2016年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSIONS: The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays an important role in the pathogenesis of middle ear diseases. Modulation of inflammasome-mediated inflammation may be a novel therapeutic strategy for cholesteatoma and chronic otitis media. OBJECTIVE: NLRP3 inflammasome is a critical molecule mediating interleukin (IL)-1β responses. However, the expression of NLRP3 in the pathogenesis of cholesteatoma and chronic otitis media has not been fully examined. This study sought to assess the expression of NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in middle ear tissues in patients with cholesteatoma or chronic otitis media. METHODS: Middle ear tissue samples were obtained from patients with cholesteatoma or chronic otitis media. Control middle ear samples were collected during cochlear implant surgery of patients without middle ear inflammation. The expression of NLRP3, ASC, and caspase-1 were examined by reverse transcription polymerase chain reaction (RT-PCR) assay and immunohistochemical study. RESULTS: The levels of mRNA of NLRP3, ASC, and caspase-1 were significantly elevated in cholesteatoma and chronic otitis media as compared with that of normal controls. The proteins of NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells in cholesteatoma and chronic otitis media.

DOI： 10.3109/00016489.2015.1093171

Impact of early intervention on comprehensive language and academic achievement in Japanese hearing-impaired children with cochlear implants. 国際誌

Akiko Sugaya, Kunihiro Fukushima, Norio Kasai, Yuko Kataoka, Yukihide Maeda, Rie Nagayasu, Naomi Toida, Shyuhei Ohmori, Akie Fujiyoshi, Tomoko Taguchi, Ryotaro Omichi, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 79 ( 12 ) 2142 - 6 2015年12月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Early hearing detection and intervention (EHDI) is critical for achievement of age-appropriate speech perception and language development in hearing-impaired children. It has been 15 years since newborn hearing screening (NHS) was introduced in Japan, and its effectiveness for language development in hearing-impaired children has been extensively studied. Moreover, after over 20 years of cochlear implantation in Japan, many of the prelingual cochlear implant (CI) users have reached school age, and the effect of CI on language development have also been assessed. To identify prognostic factors for language development, audiological/language test scores and demographic factors were compared among prelingual severe-to-profound hearing-impaired children with CI divided into subgroups according to age at first hearing aid (HA) use and whether they received NHS. METHODS: Prelingual severe-to-profound deafened children from the Research on Sensory and Communicative Disorders (RSCD) project who met the inclusion criteria were divided into groups according to the age (in months) of HA commencement (before 6 months: group A, after 7 months: group B), and the presence or absence of NHS (groups C and D). Language development and socio-economic data were obtained from audiological/language tests and a questionnaire completed by caregivers, respectively. RESULTS: In total, 210 children from the RSCD project participated in this study. Group A (n=49) showed significantly higher scores on comprehensive vocabulary and academic achievement (p<0.05) than group B (n=161), with no difference in demographics except for significantly older age in group B. No differences in language scores were observed between group C (n=71) and group D (n=129), although participants of group D was significantly older and had used CIs longer (p<0.05). CONCLUSIONS: Early use of HAs until the CI operation may result in better language perception and academic achievement among CI users with prelingual deafness. A long-term follow-up is required to assess the usefulness of NHS for language development.

DOI： 10.1016/j.ijporl.2015.09.036

蝸牛におけるステロイド作用機序 Charcot-Marie-Tooth neuropathy関連蛋白、Myelin protein zeroの制御

前田幸英, 假谷伸, 菅谷明子, 片岡祐子, 西崎和則

Otology Japan 25 ( 4 ) 618 - 618 2015年9月

Steroid-dependent sensorineural hearing loss in a patient with Charcot-Marie-Tooth disease showing auditory neuropathy. 国際誌

Yukihide Maeda, Yuko Kataoka, Akiko Sugaya, Shin Kariya, Katsuhiro Kobayashi, Kazunori Nishizaki

Auris, nasus, larynx 42 ( 3 ) 249 - 53 2015年6月

記述言語：英語掲載種別：研究論文（学術雑誌）

Charcot-Marie-Tooth disease (CMT) is the most common form of hereditary sensorimotor neuropathy and sometimes involves disorders of the peripheral auditory system. We present a case of steroid-dependent auditory neuropathy associated with CMT, in which the patient experienced 3 episodes of acute exacerbation of hearing loss and successful rescue of hearing by prednisolone. An 8-year-old boy was referred to the otolaryngology department at the University Hospital. He had been diagnosed with CMT type 1 (demyelinating type) at the Child Neurology Department and was suffering from mild hearing loss due to auditory neuropathy. An audiological diagnosis of auditory neuropathy was confirmed by auditory brainstem response and distortion-product otoacoustic emissions. At 9 years and 0 months old, 9 years and 2 months old, and 10 years and 0 months old, he had experienced acute exacerbations of hearing loss, each of which was successfully rescued by intravenous or oral prednisolone within 2 weeks. Steroid-responsive cases of CMT have been reported, but this is the first case report of steroid-responsive sensorineural hearing loss in CMT. The present case may have implications for the mechanisms of action of glucocorticoids in the treatment of sensorineural hearing loss.

DOI： 10.1016/j.anl.2014.11.002

複数の遺伝子変異を有する難聴者における遺伝カウンセリングの経験

片岡祐子, 菅谷明子, 長安吏江, 前田幸英, 福島邦博, 西崎和則

日本遺伝カウンセリング学会誌 36 ( 2 ) 78 - 78 2015年5月

当科における急性低音障害型感音難聴の治療と予後の検討

菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 西崎和則

日本耳鼻咽喉科学会会報 118 ( 4 ) 604 - 604 2015年4月

言語評価の後に補聴器装用・言語訓練の開始に至った中等度難聴の一例

中川敦子, 菅谷明子, 福島邦博, 前田幸英, 片岡祐子, 藤吉昭江, 長安吏江, 西崎和則

小児耳鼻咽喉科 36 ( 2 ) 232 - 232 2015年4月

Does the introduction of newborn hearing screening improve vocabulary development in hearing-impaired children? A population-based study in Japan. 国際誌

Shuhei Ohmori, Akiko Sugaya, Naomi Toida, Etsuji Suzuki, Masato Izutsu, Tomoko Tsutsui, Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 79 ( 2 ) 196 - 201 2015年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Permanent hearing impairment has a life-long impact on children and its early identification is important for language development. A newborn hearing screening (NHS) program has started in Okayama Prefecture, Japan, in 1999 to detect hearing impairment immediately after birth. We aim to examine the effect of this screening program on vocabulary development in pre-school children in a before and after comparative study design. METHODS: A total of 107 5-year-old children who graduated from Okayama Kanariya Gakuen (an auditory center for hearing-impaired children) between 1998 and 2011 were enrolled in this study. The pre-NHS group (n=40) was defined as those who graduated between 1998 and 2003, while the post-NHS group (n=67) was defined as those who graduated between 2004 and 2011. The primary outcome was receptive vocabulary, which was assessed by the Picture Vocabulary Test [score <18 (low) vs. score ≥18 (high)]. The secondary outcome was productive vocabulary, or the number of productive words, which was assessed by an original checklist [<1773 words (low) vs. ≥1773 (high)]. We calculated odds ratios and 95% confidence intervals for vocabulary development and compared both groups. RESULTS: The adjusted Picture Vocabulary Test score and number of productive words were significantly higher (p<0.01) in the post-NHS group than the pre-NHS group. Odds ratios were 2.63 (95% confidence interval: 1.17-5.89) for receptive vocabulary and 4.17 (95% confidence interval: 1.69-10.29) for productive vocabulary. CONCLUSIONS: The introduction of NHS in Okayama Prefecture significantly improved both receptive and productive vocabulary development in hearing-impaired children.

DOI： 10.1016/j.ijporl.2014.12.006

2年以上聴力経過を観察した小児心因性難聴の7例

前田幸英, 片岡祐子, 菅谷明子, 長安吏江, 中川敦子, 假谷伸, 西﨑和則

AUDIOLOGY JAPAN 58 ( 5 ) 335 - 336 2015年

新生児聴覚スクリーニングとの関連について

片岡祐子

小児耳鼻咽喉科 36 ( 3 ) 321 - 325 2015年

記述言語：日本語出版者・発行元：日本小児耳鼻咽喉科学会

2014年に改訂された人工内耳適応基準では，小児の適応年齢は従来の 1 歳 6 カ月以上から，1 歳以上に引き下げられた。この適応基準改定の背景には，近年の研究から低年齢での人工内耳の有用性や手術の安全性が確立されたことはさることながら，新生児聴覚スクリーニングの普及も大きく貢献していると言える。<br/> 新生児聴覚スクリーニングにより早期の療育開始が可能となり，また早期に音声による言語情報が入力されることによりコミュニケーション能力が向上する確率は有意に高くなる。本邦でも2000年度よりモデル事業として新生児聴覚スクリーニングは開始され，以後全国的に拡大しているが，スクリーニング実施にはいまだ地域差が大きいのが実情であり，全例実施されている産科施設は約半数程度でしかない。新生児聴覚スクリーニングを受け，早期に精密検査，療育へと繋げられた児では，1 歳時点で難聴の程度を判断するのは困難ではなく，早期の人工内耳手術は可能である。新生児聴覚スクリーニングとその後の診断，療育体制の整備を行うことで，難聴児の音声によるコミュニケーション能力の向上を目指したい。

DOI： 10.11374/shonijibi.36.321

その他リンク： http://search.jamas.or.jp/link/ui/2016123054

Outcomes of consonant-vowel monosyllable perception and word recognition after cochlear implantation in elderly Japanese patients. 国際誌

Ryotaro Omichi, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Shin Kariya, Kunihiro Fukushima, Kazunori Nishizaki

Acta oto-laryngologica 135 ( 11 ) 1108 - 12 2015年

記述言語：英語掲載種別：研究論文（学術雑誌）

CONCLUSION: Performance in consonant-vowel (CV) monosyllable speech perception after cochlear implantation (CI) in the elderly (≥ 65 years) is equivalent to that of young adults (18-64 years). Present data in the Japanese language supported the indication for CI in the elderly. Word recognition after CI was significantly lower in the elderly than young adults. OBJECTIVE: This study compared outcomes of monosyllable perception and word recognition after CI between elderly patients and young adults with post-lingual deafness. Age-related differences in CV monosyllable speech perception in Japanese were examined. METHODS: A retrospective chart review of 137 patients with post-lingual deafness who underwent CI at Okayama University Hospital during 1992-2014 [young adults aged 18-64 years (n = 96) and elderly aged ≥ 65 years (n = 41) at implantation] was conducted. CV monosyllable speech perception post-CI was compared among age groups (18-29, 30-39, 40-49, 50-59, 60-69, 70-79, 80-89). CV monosyllable perception and word recognition scores post-CI were compared between the elderly and young adults. RESULTS: There was no significant difference in CV monosyllable speech perception among age groups. CV monosyllable speech perception in the elderly (61.4 ± 25.5%) did not differ from that of young adults (65.9 ± 24.8%). Word recognition scores were significantly lower in the elderly (64.3 ± 28.1%) than young adults (80.4 ± 25.9%) (p < 0.05).

DOI： 10.3109/00016489.2015.1062547

[The age at which the grade of Special Child Dependent's Allowance Act can be judged in the case of deaf children].

Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 117 ( 9 ) 1200 - 4 2014年9月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The spread of neonatal hearing screening has made the identification of hearing loss in early childhood possible, and most of the children with hearing loss are diagnosed and provided with early intervention within several months after their birth. However, they have to wait to receive the Special Child Dependent's Allowance until their hearing levels are evaluated with audiometers. Under the Special Child Dependent's Allowance Act now in force, a delay of several years occurs for those children before they can receive the allowance after diagnosis. We retrospectively reviewed hearing test results of children who had not reacted at 90dBnHL bilaterally in ABR within 12 months after birth, and examined when those results were certain enough to determine their allowance eligibility. We found that the eligibility in children with hearing loss alone could be determined at 1 year of age; as for children who had other disorders, since it was mostly difficult to test them with an audiometer, the diagnosis of hearing loss must always be made carefully but it was also possible to determine the eligibility for the allowance at 1 year of age.

難聴児に対する特別児童扶養手当等級判定時期に関する検討乳児期にABR90dBnHL無反応であった児の聴力経過より

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 9 ) 1200 - 1204 2014年9月

記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

近年新生児聴覚スクリーニングの普及により、難聴児の多くは生後数ヵ月のうちに診断され、療育を開始している。一方、特別児童扶養手当に関してはオージオメーターによる検査が可能となるまで受給されず、診断から受給までの間に年単位の時間差が生じているのが現状である。われわれは、生後12ヵ月までにABRを実施し、両耳90dBnHLで無反応であった児の聴力経過の検討を行った。その結果、聴覚障害単独の児では特別児童扶養手当に該当するか否かは1歳時点で可能であるが、等級の判定は1歳で慎重な判断が必要であること、また重複障害をもつ児は検査を繰り返し慎重に診断する必要があるが特別児童扶養手当の判定は可能であると判断した。(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01099&link_issn=&doc_id=20141003450006&doc_link_id=1390282679988087552&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390282679988087552&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

当科で経験したBOR症候群の2家族例

浦口健介, 菅谷明子, 片岡祐子, 前田幸英, 假谷伸, 福島邦博, 西崎和則

Otology Japan 24 ( 4 ) 548 - 548 2014年9月

[Assessment of hearing aid outcome using CADL].

Rie Nagayasu, Yukihide Maeda, Akiko Sugaya, Yuko Kataoka, Kunihiro Fukushima, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 117 ( 8 ) 1126 - 31 2014年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The presence of hearing impairment deteriorates patients' quality of life by affecting their daily-life communication. Several self-report assessments are available to evaluate the subjective outcome of hearing aids, however, the procedures to evaluate the impairment of communication induced by hearing impairment has not been well established. A PC-recorded audio file prepared to evaluate the communication ability of hearing aid users, by extracting fifteen spoken language items from the Communication ADL Test: sp-CADL. A before and after study was performed among the hearing aid users who were attending Okayama University Hospital to evaluate the improvement in each of the 15 sp-CADL scores. Twenty-one adults were included in this study whose age ranged from 22 to 83 years old (mean: 56.7 years old). The total and individual scores of the sp-CADL improved significantly after the use of the hearing aids (p < 0.05). The total sp-CADL score of the patients with hearing aids showed a good correlation with the best scores of the speech discrimination test measured before wearing hearing aids.

実用コミュニケーション能力検査(CADL)簡易版を用いた補聴器装用効果の検討

長安吏江, 前田幸英, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 8 ) 1126 - 1131 2014年8月

記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

成人の聴覚障害者の補聴器装用効果の指標としては、日本聴覚医学会の補聴器適合指針をはじめ、各種質問紙調査が用いられている。しかし、聴覚障害に伴うコミュニケーション障害を評価するための指標は定まっていない。われわれは、実用コミュニケーション能力検査(Communication ADL Test:CADL)から音声に関する項目を抜粋し、音声ファイルを作成、このCADL簡易版を用いて、当科補聴器外来にて補聴器装用を介入とした前後比較試験を行ったところ、各15の質問項目および総得点で装用後有意な得点の改善がみられた。また、装用後の総得点は補聴器装用耳の語音明瞭度と良好な相関を認め、本検査がコミュニケーション障害のアウトカム指標に応用できる可能性が示唆された。(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2014&ichushi_jid=J01099&link_issn=&doc_id=20140902380011&doc_link_id=1390001205010834816&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001205010834816&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

当科で経験したBOR症候群の家族例

菅谷明子, 福島邦博, 前田幸英, 片岡祐子, 西崎和則

日本遺伝カウンセリング学会誌 35 ( 2 ) 80 - 80 2014年5月

岡山大学耳鼻咽喉科における補聴器外来の現況高齢者の補聴に関連して

前田幸英, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

日本耳鼻咽喉科学会会報 117 ( 4 ) 535 - 535 2014年4月

ちょっと便利な診療ツール外耳道パッキング素材

片岡祐子

JOHNS 30 ( 5 ) 2014年

耳鼻科シリーズ小児急性中耳炎診療ガイドライン

片岡祐子, 西崎和則

岡山医学会雑誌 126 ( 3 ) 2014年

当科での盲聾症候群5症例の臨床、遺伝子診断

前田幸英, 福島邦博, 片岡祐子, 菅谷明子, 西崎和則

Otology Japan 23 ( 4 ) 604 - 604 2013年10月

【検査結果をどう読むか?】聴覚領域の検査乳幼児聴力検査

菅谷明子, 片岡祐子, 福島邦博

JOHNS 29 ( 9 ) 1497 - 1499 2013年9月

Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery. 国際誌

Yuko Kataoka, Tetsuo Ikezono, Kunihiro Fukushima, Koji Yuen, Yukihide Maeda, Akiko Sugaya, Kazunori Nishizaki

Auris, nasus, larynx 40 ( 4 ) 422 - 4 2013年8月

記述言語：英語掲載種別：研究論文（学術雑誌）

Perilymphatic fistula (PLF) is defined as an abnormal leakage between perilymph from the labyrinth to the middle ear. Symptoms include hearing loss, tinnitus, and vertigo. The standard mode of PLF detection is intraoperative visualization of perilymph leakage and fistula, which ostensibly confirms the existence of PLF. Other possible methods of diagnosis include confirmation of pneumolabyrinth via diagnostic imaging. Recently, a cochlin-tomoprotein (CTP) detection test has been developed that allows definitive diagnosis of PLF-related hearing loss. We report the case of a 45-year-old man who presented with right-sided tinnitus, hearing loss, and dizziness 30 years after stapes surgery. Middle ear lavage was performed after myringotomy. A preoperative diagnosis of PLF was reached using the CTP detection test. Intraoperative observations included a necrotic long process of the incus, displaced wire piston, and fibrous tissue in the oval window. Perilymph leakage was not evident. The oval window was closed with fascia, and vertigo disappeared within 2 weeks postoperatively. When PLF is suspected after stapes surgery, the CTP detection test can be a useful, highly sensitive, and less invasive method for preoperative diagnosis.

DOI： 10.1016/j.anl.2012.08.001

Expression of toll-like receptors in chronic otitis media and cholesteatoma. 国際誌

Haruka Hirai, Shin Kariya, Mitsuhiro Okano, Kunihiro Fukushima, Yuko Kataoka, Yukihide Maeda, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 77 ( 5 ) 674 - 6 2013年5月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVE: Otitis media is one of the most common infectious diseases, especially in young children. Multiple factors affect the onset or development of otitis media. Human toll-like receptors recognize associated patterns and play a critical role in innate immune mechanisms. Toll-like receptors are considered to be important factors for clearance of infection and resolution of inflammation in otitis media. The purpose of this study was to evaluate the histological expression of toll-like receptor 2, which recognizes many kinds of pathogen-associated molecular patterns, and toll-like receptor 4, which recognizes lipopolysaccharide on Gram-negative bacteria, in tissue samples from patients with chronic otitis media and middle ear cholesteatoma. METHODS: Human middle ear tissue samples from 12 patients with chronic otitis media (n=7) and acquired middle ear cholesteatoma (n=5) were examined. Normal control middle ear samples without any inflammation were also included (n=7). The expressions of toll-like receptors 2 and 4 in middle ear tissues were examined immunohistochemically. RESULTS: Only one normal control middle ear sample showed weak expression of toll-like receptor 2, and toll-like receptor 4 was not observed in all control samples. On the other hand, both toll-like receptors 2 and 4 were markedly expressed in chronic otitis media and cholesteatoma. There was a significant difference between chronic otitis media and normal controls in the expressions of both toll-like receptors. Significant up-regulation of toll-like receptors 2 and 4 was observed in cholesteatoma as compared with control samples. CONCLUSIONS: Toll-like receptors 2 and 4 were strongly expressed in chronic otitis media and middle ear cholesteatoma. These findings suggest that toll-like receptors may play a principal role in human chronic otitis media and cholesteatoma.

DOI： 10.1016/j.ijporl.2013.01.010

乳児期にABRにて90dB無反応であった児の聴力経過

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 116 ( 4 ) 475 - 475 2013年4月

【難病への取り組み】小児難聴に対する取り組み岡山から全国への発信

片岡祐子, 福島邦博, 菅谷明子, 西崎和則

岡山医学会雑誌 124 ( 2 ) 155 - 159 2012年8月

Charcot-Marie-Tooth病に感音難聴を合併し、ステロイド依存性難聴様の経過を示した小児の1例

福島邦博, 前田幸英, 大道亮太郎, 牧野琢丸, 片岡祐子, 假谷伸, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊133 ) 83 - 83 2012年7月

CADL(実用コミュニケーション検査)による補聴器装用効果の検討

前田幸英, 菅谷明子, 福島邦博, 片岡祐子, 西崎和則

日本耳鼻咽喉科学会会報 115 ( 4 ) 494 - 494 2012年4月

生後11ヶ月で人工内耳埋込術を施行した細菌性髄膜炎後難聴の1例

濱田浩司, 菅谷明子, 片岡祐子, 前田幸英, 福島邦博, 西崎和則

小児耳鼻咽喉科 33 ( 1 ) 23 - 28 2012年3月

記述言語：日本語出版者・発行元：Japan Society for Pediatric Otorhinolaryngology

生後11ヶ月で人工内耳埋込術を施行した髄膜炎後難聴の 1 例を経験したので報告する。症例は生後 8 ヶ月で，細菌性髄膜炎に罹患し，治癒後の聴性脳幹反応検査では両側 105 dBnHL で反応がみられなかった。内耳 MRI の 3D 再構築画像で右内耳は既に閉塞し，内耳内腔の骨化が急速に進行していると考えられた。左内耳は今後閉塞が高度となる可能性が考えられ，直ちに左人工内耳埋込術を施行した。髄膜炎後の難聴にはしばしば蝸牛内骨化を伴うが，中には髄膜炎罹患後約 2 週間から内耳骨化が進行するような，急速な骨化例もある。髄膜炎直後の乳児では難聴の早期発見のための ABR 検査や，難聴の存在を疑われた場合の迅速な MRI 検査は不可欠である。

DOI： 10.11374/shonijibi.33.23

その他リンク： http://search.jamas.or.jp/link/ui/2012208704

外耳道扁平上皮癌との鑑別が困難であった外耳道耳垢腺腫の1例

假谷伸, 福島邦博, 片岡祐子, 前田幸英, 西崎和則

Otology Japan 22 ( 1 ) 36 - 39 2012年2月

記述言語：日本語出版者・発行元：THE JAPAN OTOLOGICAL SOCIETY

耳垢腺腫は外耳道の耳垢腺を発生母地とする良性腫瘍であり、多彩な組織所見を呈することから微少な組織からでは診断が困難であるとされている。今回、我々は術前の生検にて扁平上皮癌が疑われた耳垢腺腫症例を経験したので報告する。症例は59歳女性。主訴は耳漏であり、それ以外の自覚症状は認められなかった。術前の生検を2回行ったが、ともに扁平上皮癌の疑いという結果であった。耳内法による腫瘍切除術と耳後部有茎皮弁による外耳道再建を施行した。最終病理診断は耳垢腺腫であった。術後、1年半を経過し、再発は認められていない。

DOI： 10.11289/otoljpn.22.36

その他リンク： http://search.jamas.or.jp/link/ui/2012167712

当院における再手術・追加手術を要した小児の人工内耳症例5例の検討

菅谷明子, 福島邦博, 片岡祐子, 前田幸英, 笠井紀夫, 平井美紗都, 長安吏江, 西崎和則

小児耳鼻咽喉科 32 ( 3 ) 409 - 414 2011年12月

記述言語：日本語出版者・発行元：Japan Society for Pediatric Otorhinolaryngology

一般的には人工内耳術後再手術の適応には，機器の故障，血腫の形成，創部感染，および電極の位置不良などが挙げられる。また最近の手術時年齢の低下からは，耳管機能の未熟さに伴い，経過中に中耳疾患を合併することも少なくない。<br/> 今回当院で実施した小児の人工内耳埋め込み術150例のうち再手術を要した 3 例および追加手術を要した 2 例について検討した。再手術の 3 例は全員機器不良によるものであり，同側の人工内耳 explant/implant 術を施行した。また，追加手術の 2 例では鼓膜換気チューブ留置術および鼓膜形成術を施行した。このうち外傷後に再手術を行った内耳奇形の 1 例の詳細を報告した。<br/> 再手術を要する症例では失聴期間をできるだけ短くするために迅速な対応を行い，術側の決定および術中の電極の位置確認を慎重に行うことが重要であると考える。

DOI： 10.11374/shonijibi.32.409

その他リンク： http://search.jamas.or.jp/link/ui/2012118058

軽度および中等度難聴児における就学期における言語発達の検討

片岡祐子, 福島邦博, 菅谷明子, 前田幸英, 西崎和則

Otology Japan 21 ( 4 ) 738 - 738 2011年10月

Expression analysis of microRNAs in murine cochlear explants 査読

Misato Hirai, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Yuko Kataoka, Kazunori Nishizaki

NEUROREPORT 22 ( 13 ) 652 - 654 2011年9月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：LIPPINCOTT WILLIAMS & WILKINS

MicroRNAs (miRNAs) play functional roles in sound transduction in cochlea. This study focuses on the validity of cochlear culture as an in vitro experimental tool, in view of miRNA expression. E15 cochleae were dissected and maintained in vitro for 48 h before extraction of miRNAs. MiRNA expression was comprehensively screened in explanted cochleae using a miRNA array that covers 380 miRNAs. A strong correlation was observed between expression levels of miRNAs in in vitro and in in vivo cochleae. Levels of 43 miRNAs were altered in vitro and these changes were reproducible over three trials. These findings indicate that in vitro miRNA profiling is a viable method for analysis of gene expression and action of chemical compounds on cochleae. NeuroReport 22:652-654 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

DOI： 10.1097/WNR.0b013e32834a0273

当院で人工内耳手術を施行した児の言語発達の特徴

菅谷明子, 福島邦博, 笠井紀夫, 片岡祐子, 前田幸英, 長安吏江, 問田直美, 大森修平, 西崎和則

Audiology Japan 54 ( 5 ) 513 - 514 2011年9月

両側人工内耳装用児の聴取と発音明瞭度の継時的変化

問田直美, 大森修平, 福島邦博, 片岡祐子, 菅谷明子, 西崎和則

Audiology Japan 54 ( 5 ) 369 - 370 2011年9月

[Subsidizing hearing aid purchase in mild to moderate pediatric hearing--pediatric status following prefectural assembly subvention].

Yuko Kataoka, Kunihiro Fukushima, Akiko Sugaya, Yukihide Maeda, Yu Masuda, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 114 ( 8 ) 731 - 6 2011年8月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The dissemination of newborn hearing screening (NHS) has enabled those with mild to moderate hearing loss to be diagnosed in early infancy. The "handicapped independence support law", however, prevents those not determined to be physically handicapped; i.e., those with mild to moderate hearing loss-, from government assistance in purchasing hearing aids. This results either in (i) parents purchasing hearing aids at their own expense or (ii) nonpurchase of hearing aids. To redress this situation, subvention in purchasing hearing aids of mild to moderate hearing loss children has been begun by some local governments. We petitioned for such aid at the Okayama Prefecture Assembly. A society for supporting pediatric hearing difficulty in Okayama Prefecture also submitted a similar petition in September 2009, and subvention began in April 2010 for all such children in Okayama Prefecture. We report procedures and details leading to this subvention.

[Progressive or delayed early-onset pediatric sensorineural hearing loss].

Yuko Kataoka, Kunihiro Fukushima, Yukihide Maeda, Akiko Sugaya, Rie Nagayasu, Yu Masuda, Kazunori Nishizaki

Nihon Jibiinkoka Gakkai kaiho 114 ( 6 ) 557 - 61 2011年6月

記述言語：日本語掲載種別：研究論文（学術雑誌）

The introduction of newborn-hearing screening has enabled early childhood hearing loss to be diagnosed and increased the number of children undergoing early care. Bilateral hearing loss is found in 0.08% of newborns and children whose hearing loss progresses or onset is delayed account for 4 to 30% of all pediatric hearing impairment. Children with perinatal risk factors tend to have deteriorated hearing or delayed-onset hearing loss in early childhood, necessitating audiometric follow-up. We also are aware of some children without risk factors who develop hearing impairment during infancy or early childhood. Hearing deterioration may be difficult to diagnose objectively, especially in young children, the presence of risk factors must be determines as soon as possible, especially given the lack of hearing management and close examination of children without apparent risk factors. We retrospectively studied children born from April 1998 to March 2007 and undergoing cochlear implantation as of April 2008. Among cases, we focused on 10 whose hearing impairment advanced during infancy -4 with risk factors known before hearing deterioration progressed, and 6 cases thought not to have any risk factors. We detected enlarged vestibular acquaduct in 3 of these 6 cases, and 3 more of whom had no risk factors -2 passing newborn-hearing screening and 1 in whom such screening detected hemilateral hearing loss. Our results underscore the need for early temporal computed tomography for detecting enlarged vestibular aquaduct. Even children with mild or hemilateral hearing loss should undergo audiometric and developmental testing at least every 6 months up to going to elementary school. Children suspected of impaired hearing should undergo thorough hearing tests regardless of newborn hearing-screening results to catch any problems early. Appropriate regular hearing and language development check-up tests must also be developed.

人工内耳手術を施行した進行性および遅発性難聴症例の検討

片岡祐子, 福島邦博, 前田幸英, 菅谷明子, 長安吏江, 増田游, 西崎和則

日本耳鼻咽喉科学会会報 114 ( 6 ) 557 - 561 2011年6月

記述言語：日本語出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

新生児聴覚スクリーニング検査導入以後、乳児期および幼児期早期に難聴の確定診断がされ、療育が行われる例が増加した。しかし、乳幼児期に難聴が進行する児や、新生児期には難聴が認められなかったにもかかわらず遅発性に難聴を発症した児が存在することが報告され、その割合は難聴児の4-30%に及ぶとされている。進行性および遅発性難聴児の中に、難聴の危険因子を予見できない児が少数ながら存在することも明らかになっている。今回われわれは1998年4月から2007年3月までに出生した岡山県在住の小児で、2008年4月までに当院で人工内耳埋込み術を行った45例の中から乳幼児期に進行性および遅発性難聴が認められた10例(人工内耳装用児中の22.2%)を抽出し、新生児期に危険因子をもたないと考えられていた6例について詳細に検討した。6例中3例では、難聴進行後に画像検査にて前庭水管拡大症が発見されたが、他の3例の原因は不明であった。対象数は少ないが、新生児期に難聴の危険因子をもたない半数に画像検査で前庭水管拡大症が発見されたことにより、可能な限り画像検査を行うことが難聴増悪の早期発見の点から望ましいと考えられた。また、進行性難聴や新生児聴覚スクリーニング検査にパスした場合でも乳幼児期に遅発性難聴となる可能性があることを念頭に置き、就学前までは定期的な聴覚検査や現在自治体で行われている健診における聴覚に関する質問事項や検査の充実なども考慮すべきである。(著者抄録)

その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2011&ichushi_jid=J01099&link_issn=&doc_id=20110708420003&doc_link_id=1390001205012106368&url=https%3A%2F%2Fcir.nii.ac.jp%2Fcrid%2F1390001205012106368&type=CiNii&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00003_3.gif

当院における再手術・追加手術を要した小児の人工内耳症例

菅谷明子, 福島邦博, 片岡祐子, 前田幸英, 笠井紀夫, 平井美紗都, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 186 - 186 2011年5月

軽度・中等度難聴児に対する「岡山県難聴児補聴器交付事業」導入1年間の実施状況

片岡祐子, 菅谷明子, 福島邦博, 前田幸英, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 193 - 193 2011年5月

急性乳様突起炎を契機に発見された真珠腫性中耳炎の1例

松本淳也, 菅谷明子, 片岡祐子, 福島邦博, 西崎和則

小児耳鼻咽喉科 32 ( 2 ) 205 - 205 2011年5月

中耳洗浄液CTP検出により術前診断が可能であった外リンパ瘻例

片岡祐子, 池園哲郎, 福島邦博, 結縁晃治, 濱田浩司, 菅谷明子, 前田幸英, 西崎和則

日本耳鼻咽喉科学会会報 114 ( 4 ) 390 - 390 2011年4月

IL-1受容体アンタゴニストが感音難聴の治療に奏功したクリオピリン関連症候群の1例

平井美紗都, 菅谷明子, 前田幸英, 片岡祐子, 假谷伸, 福島邦博, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊128 ) 109 - 109 2010年6月

回転性めまいをきたした小児前庭水管拡大症の2例

菅谷明子, 前田幸英, 片岡祐子, 平井美紗都, 福島邦博, 西崎和則

耳鼻咽喉科臨床補冊 ( 補冊128 ) 117 - 117 2010年6月

急性高度難聴に関する調査研究難聴関連コネキシンの組織別発現パターン

福島邦博, 前田幸英, 平井美紗都, 片岡祐子

急性高度難聴に関する調査研究平成21年度総括・分担研究報告書 2010年

人工内耳埋め込み術を行った Townes-Brocks 症候群の1例

平井美紗都, 福島邦博, 片岡祐子, 長安吏江, 前田幸英, 假谷伸, 西崎和則

小児耳鼻咽喉科 30 ( 3 ) 222 - 226 2009年12月

記述言語：日本語出版者・発行元：Japan Society for Pediatric Otorhinolaryngology

Townes-Brocks 症候群（TBS）は，1972年に Townes PL と Brocks ER が初めて報告した，手指，鎖肛などの多彩な外表奇形に加えて，外耳道閉鎖症をはじめとした各種の耳形態異常を伴う常染色体優性遺伝の奇形症候群である。今回我々は，内耳形態異常による高度難聴を伴った TBS の 1 例に対して人工内耳埋め込み術を行ったので報告する。<br/> 症例は，外耳，内耳の高度形態異常を伴っていたが，医療用画像診断システムを用いた解析により人工内耳埋め込み術の適応決定，及び術前のプランニングを行うことが可能であった。

DOI： 10.11374/shonijibi.30.222

その他リンク： http://search.jamas.or.jp/link/ui/2010091910

Cochlear Implantation for Children with Auditory Neuropathy Among Japanese Language Users 査読

Kunihiro Fukushima, Yuko Kataoka, Yukihide Maeda, Shin Kariya, Susumu Tominaga, Rie Nagayasu, Akihiro Kawasaki, Shouichiro Fukuda, Naomi Toida, Kazunori Nishizaki

NEUROPATHIES OF THE AUDITORY AND VESTIBULAR EIGHTH CRANIAL NERVES 71 - + 2009年

記述言語：英語掲載種別：研究論文（国際会議プロシーディングス）出版者・発行元：SPRINGER

Among 80 prelingually deafened children who underwent cochlear implant at Okayama University Hospital, two auditory neuropathy/auditory dys-synchrony (AN/AD) cases with cochlear implant were identified from review of medical records. These two cases first demonstrated stable responses with distortion product otoacoustic emission, although later the response disappeared. In spite of the presence of AN/AD, the language development of these cases was quite satisfactory so far. Herein, we report the clinical course and language development of these auditory neuropathy cases with cochlear implant.

DOI： 10.1007/978-4-431-09433-3_8

Auditory steady-state responses to multiple simultaneous stimuli in children with functional or sensorineural hearing loss 査読

Shin Kariya, Kunihiro Fukushima, Akihiro Kawasaki, Yuko Kataoka, Kazunori Nishizaki

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 265 ( 7 ) 769 - 773 2008年7月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：SPRINGER

The goal of our study was to identify the role of auditory steady-state responses for hearing assessment in patients with functional hearing loss. The study design was to compare auditory steady-state response thresholds and standard pure-tone audiometry thresholds between patients with functional or sensorineural hearing loss. Subjects comprised 16 patients (24 ears) with functional hearing loss and 17 patients (24 ears) with sensorineural hearing loss. Differences and correlations between auditory steady-state response thresholds and standard pure-tone audiometry thresholds at 500, 1,000, 2,000 and 4,000 Hz were evaluated. In children with functional hearing loss, pure-tone audiometry thresholds and auditory steady-state response thresholds were significantly different at all frequencies and were not significantly correlated. In patients with sensorineural hearing loss, pure-tone audiometry thresholds and auditory steady-state response thresholds did not differ significantly at any frequencies and were significantly correlated. Auditory steady-state responses may have principal role in the assessment of auditory brainstem acuity, particularly at low frequencies in patients with functional hearing loss.

DOI： 10.1007/s00405-007-0550-3

Developmental dysgraphia with profound hearing impairment: Intervention by auditory methods enabled by cochlear implant 査読

Kunihiro Fukushima, Akihiro Kawasaki, Rie Nagayasu, Kazuya Kunisue, Yukihide Maeda, Shin Kariya, Yuko Kataoka, Kazunori Nishizaki

AURIS NASUS LARYNX 35 ( 2 ) 250 - 254 2008年6月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI LTD

Learning disability combined with hearing impairment (LDHI) is a poor prognostic factor for the language development of hearing impaired children after educational intervention. A typical example of a child with LDHI and effective interventions provided by cochlear implants are presented in this report. A case of congenital cytomegaloviral infection that showed dysgraphia as well as profound deafness was reported and an underlying visual processing problem diagnosed in the present case caused the patient's dysgraphia. The dysgraphia could be circumvented by the use of auditory memory fairly established by a cochlear implant. (C) 2007 Published by Elsevier Ireland Ltd.

DOI： 10.1016/j.anl.2007.07.013

Comprehension of abstract words among hearing impaired children 査読

Kazuya Kunisue, Kunihiro Flukushima, Akihiro Kawasakia, Yukihide Maeda, Rie Nagayasu, Yuko Kataoka, Shin Kariya, Yasuyo Fukutomi, Haruhisa Takami, Kazunori Nishizaki

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 71 ( 11 ) 1671 - 1679 2007年11月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Introduction: This study examines the ability and development in the comprehension of abstract words with hearing impaired children. The ability to understand abstract words is quite important for their academic learning and adaptation in their school life. Here, we qualitatively and quantitatively analyzed the development of abstract vocabulary in hearing impaired children using The Standardized Comprehension Test for Abstract Words (SCTAW).
Subjects and methods: We examined 75 hearing impaired children (hearing aid users, 61; cochlear implant users, 14; 1st to 10th grade) and 188 children with normal hearing (1st to 6th grade) using the Picture Vocabulary Test (PVT) and SCTAW.
Results: The PVT and SCTAW results closely correlated (r = 0.87). The SCTAW scores of the hearing impaired group were lower than those of their peers with normal. hearing, but the scores improved as their school. grade advanced. In particular, their abstract ability began to catch up from the fifth grade. The error trends of abstract vocabulary in the two groups did not significantly differ.
Conclusions: The SCTAW was useful as an abstract lexical. evaluation of hearing impaired children. The development of an abstract vocabulary did not qualitatively differ between children with or without a hearing impairment. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijport.2007.06.015

新生児聴覚スクリーニングで発見された聴覚障害児の小学校就学時点での評価

福田章一郎, 問田直美, 福島邦博, 片岡祐子, 西崎和則

AUDIOLOGY JAPAN 50 ( 4 ) 254 - 260 2007年

記述言語：日本語出版者・発行元：Japan Audiological Society

新生児聴覚スクリーニングが本邦でも開始され, その評価が待たれている。評価は, 多面的であるべきであるし長期間を要する。新生児聴覚スクリーニングで発見され, 就学時に評価が可能であった聴覚障害児7例の療育効果を検討した。聴能および知的に遅れがみられなかった5例の言語発達は年齢並でなかでも人工内耳装用児4例は特に良好であった。知的境界領域であった1例は, 聴能の発達は良かったが言語発達にはかなりの遅れが認められた。また, 知的には遅れは認められないが, 聴能の発達に遅れが見られた1例も言語発達に大きな遅れが認められた。したがって, 知的あるいは聴能に遅れが認められない場合, スクリーニング後すみやかに診断, 療育が実施され聴覚評価の後人工内耳による療育を行うことが高度難聴児の一つの療育モデルになると考えられる。さらに, 新生児スクリーニングの有効性を確立するためには今後さらに効果的な療育法の検討が必要である。

DOI： 10.4295/audiology.50.254

当院における小児進行性・遅発性難聴の人工内耳埋込み術施行症例の検討

片岡祐子, 福島邦博, 福田章一郎, 長安吏江, 西崎和則

AUDIOLOGY JAPAN 50 ( 5 ) 453 - 454 2007年

医用画像情報システムを利用した側頭骨画像診断査読

西崎和則, 冨永進, 福島邦博, 假谷伸, 片岡祐子

耳鼻と臨床 53 ( 1 ) 8 - 13 2007年

医用画像情報システムを使用した側頭骨手術シミュレーション査読

西崎和則, 福島邦博, 片岡祐子, 假谷伸, 冨永進

耳鼻と臨床 53 ( 4 ) 191 - 196 2007年

就学前時のひらがな書字習得に必要な認知機能の精査 : 発達性読み書き障害児の就学前介入を目的とした評価試案

川崎聡大, 杉下周平, 福島邦博, 新川里佳, 新城温子, 片岡祐子, 児山昭江, 西崎和則

小児耳鼻咽喉科 27 ( 3 ) 262 - 266 2006年12月

記述言語：日本語出版者・発行元：日本小児耳鼻咽喉科学会

言語習得期前難聴児が示す言語発達の経過は非常に多様であり,聴能訓練が順調に推移した症例が必ずしも良好な経過をたどるとは限らない。難聴児における学習障害の合併率は10%前後と報告されており,その中核症状である発達性dyslexiaが存在すると,難聴児の言語発達には大きな影響を受ける。しかし学齢期の前にスクリーニングすることはきわめて困難であり,難聴要因を加味して検討することはさらに困難である。今回学齢前児37名を対象として,読み書きに必要な認知能力の精査を行った。実施した検査はレイベン色彩マトリックス検査SetA(RCPM),言語発達遅滞検査(S-S法),ベントン視覚記銘力検査,音韻認識処理課題,かな一文字の書字及び読字課題を実施した。結果,(1)S-SやRCPMはカットオフの指標として有用である。(2)かな読字は月齢と相関しない。書字は月齢60カ月を境に急速に達成可能となる傾向が明らかとなった。

DOI： 10.11374/shonijibi1980.27.3_262

その他リンク： http://search.jamas.or.jp/link/ui/2007099016

Using assessment of higher brain functions of children with GJB2-associated deafness and cochlear implants as a procedure to evaluate language development 査読

Akihiro Kawasaki, Kunihiro Fukushima, Yuko Kataoka, Shoichiro Fukuda, Kazunori Nishizaki

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 70 ( 8 ) 1343 - 1349 2006年8月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER IRELAND LTD

Objective: While investigators have reported that patients with GJB2-associated deafness and cochlear implants have preferable language development, the mechanisms of this phenomenon remains unknown. The goat of the present study was to assess higher brain functions of patients with GJB2-retated and GJB2-unrelated deafness as a method of evaluating language development.
Methods: Eight children with cochlear implants were subjected to genetic testing for GJB2 and underwent the Raven colored progressive matrices test, Rey's auditory verbal learning test, Rey's complex figure test, the standardized Language test for aphasia, the picture vocabulary test, and the standardized comprehension test for abstract words.
Results: Three children were diagnosed with GJB2-related deafness, and five children were diagnosed with GJB2-unrelated deafness. All three GJB2-related cases demonstrated normal range higher brain functions and fair language development. By contrast, one GJB2-unrelated case showed a semantic disorder, another demonstrated a visual cognitive disorder with dyslexia, and another had attention deficit-hyperactivity disorder.
Conclusions: Children with GJB2-unrelated deafness showed a high frequency of heterogeneous disorders that can affect proper language development. This difference between children with GJB2-retated and GJB2-unrelated deafness may account for the improved language development in children with GJB2-related deafness and cochlear implants. Further, genetic diagnosis of the non-syndromic hearing toss represents a useful tool for the preoperative prediction of outcomes following a cochlear implant procedure. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/j.ijporl.2006.01.010

前庭・蝸牛周囲の緻密骨中に骨透亮像を呈した混合難聴合併exomphalosmacroglossia-gigantism (EMG)症候群の1例

福山祐子, 福島邦博, 片岡祐子, 假谷伸, 西崎和則

耳鼻と臨床 52 ( 6 ) 338 - 341 2006年

記述言語：日本語出版者・発行元：耳鼻と臨床会

Beckwith-Wiedemann症候群は脇ヘルニア (exomphalos) 、巨舌 (macroglossia) 、巨人症 (gigantism) を三主徴とする遺伝性疾患であり (以下EMG症候群) 、まれに伝音難聴を伴うことが報告されている。今回、EMG症候群に合併した混合性難聴の1例を経験したので報告する。症例は9歳女児、軽度の難聴を指摘され、当院紹介となった。純音聴力検査の結果では両側の軽度混合性難聴を認め、画像所見では前庭・蝸牛周囲の緻密骨中に骨透亮像を認めた。既報では、手術時にアブミ骨固着による難聴であることが確認されているが、EMG症候群の側頭骨画像は、今回はじめて報告する。これらの所見からも、本症例は耳硬化症と類似する病態が存在すると考えられた。

DOI： 10.11334/jibi1954.52.6_338

その他リンク： http://search.jamas.or.jp/link/ui/2007108867

人工内耳装用による語音明瞭度改善例の異聴傾向

福田章一郎, 問田直美, 福島邦博, 片岡祐子, 西崎和則

AUDIOLOGY JAPAN 49 ( 6 ) 798 - 802 2006年

記述言語：日本語出版者・発行元：Japan Audiological Society

人工内耳埋め込み後, 語音明瞭度の改善が顕著であった先天性感音難聴児9例の異聴傾向を検討した。人工内耳装用後, 適切なマッピングによる聴覚学習と療育を受けた結果, 57語表による語音検査で9症例の平均は85.1%となり非常に高い明瞭度が得られた。人工内耳装用児の異聴傾向は有声破裂音を除き難聴者とほぼ同じ傾向を示した。無声子音の明瞭度は有声子音に比し高かった。特に, 摩擦音の明瞭度が高かったがこれは人工内耳の場合は補聴器と比較し, 高い周波数まで聴取可能であるため明瞭度の向上が得られたことによると考えられる。人工内耳の語音聴取の改善には周波数分解能と同時に時間分解能が関与していることが示唆され, 個々の異聴傾向はそれぞれの複雑な組み合わせによるものと考えられる。しかしながら, 摩擦音, 破擦音では構音点が後方であるほど明瞭度が低下する傾向がみられ, 今後の検討課題である。

DOI： 10.4295/audiology.49.798

新生児難聴スクリーニングとその後の対応新生児聴覚スクリーニングから精密聴力検査へ

福島邦博, 片岡裕子, 西崎和則

AUDIOLOGY JAPAN 49 ( 3 ) 227 - 232 2006年

記述言語：日本語出版者・発行元：Japan Audiological Society

新生児聴覚スクリーニングでは, 母子の愛着形成の前に行われる難聴の告知が母親の不安を増幅し, これがスクリーニングを行うことの問題点であると考えられてきた。我々は, 岡山県聴覚検査事業の中で行われている保健師による訪問指導調査票を精査し, その結果をレトロスペクティブに解析した。訪問指導では, 母親の不安や心配に関する質問が行われ, 聴覚スクリーニング後の精密検査の有無が確認されていた。調査期間の間, 47346人のスクリーニングが行われ, そのうち248人がリファーと診断された。その中では171人の調査報告書が岡山県に報告されていた。この171人中では, 39人は不安を訴えたが, 39人中19人は合併する障害があり, 心配の中心はその他のより重篤な障害であった。16例は訪問指導の時点では診断ないしは受容の途上であり, 4例の片側例でのみ予想外の不安が見られた。育児放棄は多発奇形の一例に見られた。聴覚スクリーニング後の不安の頻度は一般の産後の不安と変わらないが, 日本における新生児聴覚スクリーニングの成功のためには, 不安や心配を最小限にする努力が必要である。

DOI： 10.4295/audiology.49.227

聴性定常反応検査の周波数別聴力:標準純音聴力検査との比較:-BIS値を指標とした覚醒度の与える影響- 査読

川崎聡大, 福島邦博, 片岡祐子, 市川智継, 中塚秀樹, 西崎和則

耳鼻と臨床 52 ( 1 ) 33 - 37 2006年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：JIBI TO RINSHO KAI

聴性定常反応検査 (auditory steady stateresponse:以下ASSRと略す) は、周波数特異的な聴性反応が得られる聴力像の推定が可能な新しい他覚的聴力検査法の一つとして期待される。今回われわれはトロント大学方式を採用した高変調周波数を用いた NavigaterPro (解析ソフトウェアMASTERTM) を用いて標準純音聴力検査とASSR閾値との相関について検討した。さらにBispectral Index (以下BIS値とする) を指標として覚醒度が与えるASSR結果への影響について検討を加えた。結果、1) 標準純音聴力検査との間に一定の相関を認めたこと、2) 覚醒度が高い場合に結果の信頼性に問題があること、3) BIS値の低下した症例では比較的困難とされる低い音圧での閾値の推定が可能であったことが判明し、覚醒状態の与えるASSR閾値への影響について知見を得ることができた。

DOI： 10.11334/jibi1954.52.1_33

軽度難聴児の言語発達に与える高次脳機能 : 神経心理学的評価に基づく認知特性の検討査読

川崎聡大, 杉下周平, 福島邦博, 片岡祐子, 長安吏江, 市川智継, 西崎和則

小児耳鼻咽喉科 26 ( 2 ) 51 - 55 2005年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：Japan Society for Pediatric Otorhinolaryngology

Learning disability is the single most frequent complication of hearing impairment, occurring in up to 15% of all school-aged deaf children. Neuropsychological evaluations of these cases may contribute to further diagnosis of the additional handicaps and the identification of a suitable procedure for better intervention. A nine-year-old boy with mild hearing impairment was referred to our hospital because of his poor language development. His average pure tone audiometry was 35dBnHL in the right ear and 65 dBnHL in the left ear and audiological interventions with a hearing aid had already been started before the referral to our clinic. Although mild mental retardation was suggested by WISC-III, as FIQ65 (VIQ 65, VIQ71, and PIQ65), non-verbal intelligence examined by RCPM corresponded to the normal range. Verbal and non-verbal semantic disorder was considered by the results from ScTaw and SLTA. He was later diagnosed as having Asperger syndrome and his semantic problem concomitant with Asperger syndrome could be another cause of his additional language delay.

DOI： 10.11374/shonijibi1980.26.2_51

認知能力の個人内差が人工内耳装用後の言語発達に及ぼした影響

川崎聡大, 福島邦博, 福本裕子, 長安吏江, 国末和也, 片岡裕子, 西崎和則

小児耳鼻咽喉科 25 ( 2 ) 46 - 50 2004年12月

記述言語：日本語出版者・発行元：日本小児耳鼻咽喉科学会

A considerable number of prelingually-deafened children with cochlear implants demonstrated discrepancies between their speech perception ability and language development. The difference may be caused partly by the intrapersonal discrepancies among cognitive functions, including visual and auditory cognitive functions. Different clinical outcomes were observed among 3 prelingual deafness cases with cochlear implants and the profiles of their language development and neuropsychological tests were reported here. One case (MW) demonstrated the proper syntactic strategy corresponding to her hearing peers and neuropsychological evaluations revealed that her cognitive functions were well balanced. Two other cases (SN and YH) demonstrated considerable delay in the syntactic strategy for their communication and visual cues were needed to accomplish the interventional goal. It was assumed that the auditory memories of these two cases were affected. Although their medical and educational backgrounds were highly similar, the first outcome and the consequent procedures for intervention were different. Neuropsychological tests can provide crucial information for the optimum interventional approach for implant users.

DOI： 10.11374/shonijibi1980.25.2_46

その他リンク： http://search.jamas.or.jp/link/ui/2005089882

Monosyllable speech perception of Japanese hearing aid users with prelingual hearing loss: Implications for surgical indication of cochlear implant

Shoichiro Fukuda, Kunihiro Fukushima, Naomi Toida, Keiko Tsukamura, Yukihide Maeda, Namiki Kibayashi, Rie Nagayasu, Yorihisa Orita, Norio Kasai, Yuko Kataoka, Kazunori Nishizaki

International Journal of Pediatric Otorhinolaryngology 67 ( 10 ) 1061 - 1067 2003年10月

掲載種別：研究論文（学術雑誌）

Objective: The monosyllable speech perception ability after years of educational intervention was compared between prelingually deafened pediatric hearing aid users and their cochlear implant counterparts. Design: An open-set monosyllabic speech perception test was conducted on all subjects. The test required subjects to indicate a corresponding Japanese character to that spoken by the examiner. Fifty-two subjects with prelingual hearing impairment (47 hearing aid users and 5 cochlear implant users) were examined. Results: Hearing aid users with average pure-tone thresholds less than 90 dB HL demonstrated generally better monosyllable perception than 70%, which was equivalent or better performance than that of the cochlear implant group. Widely dispersed speech perception was observed within the 90-99 dB HL hearing-aid user group with most subjects demonstrating less than 50% speech perception. In the cluster of > 100 dB HL, few cases demonstrated more than 50% in speech perception. The perception ability of the vowel part of each mora within the cochlear implant group was 100% and corresponding to that of hearing aid users with moderate and severe hearing loss. Conclusion: Hearing ability among cochlear implant users can be comparable with that of hearing aid users with average unaided pure-tone thresholds of 90 dB HL, after monosyllabic speech perception testing was performed. © 2003 Elsevier Ireland Ltd. All rights reserved.

DOI： 10.1016/S0165-5876(03)00187-3

Meniere's disease in childhood 査読

Hirofumi Akagi, Koji Yuen, Yukihide Maeda, Kunihiro Fukushima, Shin Kariya, Yorihisa Orita, Yuko Kataoka, Teruhiro Ogawa, Kazunori Nishizaki

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 61 ( 3 ) 259 - 264 2001年12月

記述言語：英語掲載種別：研究論文（学術雑誌）出版者・発行元：ELSEVIER SCI IRELAND LTD

We report 3 rare cases of Meniere's disease in children. In Case I and 3, vertigo, hearing loss and tinnitus recovered soon after medical therapy. In Case 2. however, vertigo recurred and the hearing level on the right side markedly deteriorated. The equal-loudness contours on three-dimensional audiogram showed that right-sided aggravated hearing loss fluctuated for 4 years at middle-and low-frequencies despite medication. Finally intratympanic injection of gentamicin sulfate was performed. The patient has had no definitive spell of vertigo after gentamicin therapy. At our department, the incidence of Meniere's disease in pediatric patients with vertigo was 2.9%. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

頸部リンパ節腫脹で発症した顆粒球肉腫例

片岡祐子, 赤木博文, 木村宣彦, 中島智子, 小川晃弘, 西崎和則

耳鼻咽喉科臨床 94 ( 7 ) 645 - 648 2001年7月

記述言語：日本語出版者・発行元：The Society of Practical Otolaryngology

Granulocytic sarcoma was first described by Burns in 1811 and it is known to be an extramedullary tumor composed of immature precursor cells. It sometimes occurs with acute myeloid leukemia or myeloproliferative disorders, but there have been reports of cases occurring without such hematological disorders. A 40-year-old female with a chief complaint of neck swelling was examined in our department in 1997. CT scan showed bilateral neck lymph nodes swelling. Histological examination of open biopsy confirmed myeloblastic-type tumor cells, but peripheral blood and bone marrow examination showed no evidence of leukemia. The final diagnosis of this case was granulocytic sarcoma without hematological disorder.

DOI： 10.5631/jibirin.94.645

その他リンク： http://search.jamas.or.jp/link/ui/2002017688

IgA腎症の長期予後(10年予後)

赤木博文, 土井彰, 福島邦博, 片岡祐子, 小坂道也, 小川晃弘, 西崎和則

口腔・咽頭科 14 ( 1 ) 2001年

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