研究者詳細 - 片岡　祐子

論文 - 片岡　祐子

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【結果の読み方がよくわかる! 耳鼻咽喉科検査ガイド】聴覚検査聴性定常反応(ASSR) 招待

片岡祐子

耳鼻咽喉科・頭頸部外科 94 ( 5 ) 54 - 59 2022年4月

担当区分：筆頭著者記述言語：日本語出版者・発行元：(株)医学書院

＜文献概要＞POINT ◆聴性定常反応(ASSR)は他覚的に聴覚閾値を測定する検査法で,周波数特異性に優れている.◆乳幼児,知的障害や認知機能低下者,機能性難聴者など,純音聴力検査の信頼性が低い者の聴力評価に有用である.

The fine-needle aspiration cytology and clinical findings of Kikuchi-Fujimoto disease in pediatric patients: a retrospective clinical study. 査読国際誌

Yuto Naoi, Tomoyasu Tachibana, Yoji Wani, Machiko Hotta, Katsuya Haruna, Yasutoshi Komatsubara, Kazunori Kuroda, Soichiro Fushimi, Tami Nagatani, Yuko Kataoka, Kazunori Nishizaki, Yasuharu Sato, Mizuo Ando

Acta oto-laryngologica 142 ( 3-4 ) 340 - 344 2022年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

BACKGROUND: Histological evaluation of lymph node is crucial for the definitive diagnosis of Kikuchi-Fujimoto disease (KFD). However, lymph node biopsy under local anesthesia is often difficult in pediatric patients. OBJECTIVES: We evaluated cytological findings for pediatric patients with prolonged cervical lymphadenitis clinically suggestive of KFD and investigated the clinical characteristics of patients diagnosed with KFD by fine-needle aspiration cytology (FNAC). METHODS: This retrospective clinical study included 58 Japanese pediatric patients with cervical lymphadenitis who underwent FNAC. RESULTS: Cytological diagnosis was KFD for 22 and suspicion of KFD for 11 patients. The remaining 25 patients were diagnosed with non-specific lymphadenitis (NSL). Tenderness was independently associated with a higher frequency of both KFD in narrow and broad senses, compared with NSL (p = .009; p = .038). The percentage of patients who underwent FNAC within 28 days from symptom onset tended to be higher among patients with KFD in a narrow sense than those with NSL (p = .052). CONCLUSION: This study indicated that the period from symptom onset to FNAC (<28 days) and the symptom of tenderness were associated with the cytological diagnosis of KFD.

DOI： 10.1080/00016489.2022.2040744

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小児、思春期・若年がん患者に対する妊孕性温存療法　現状と改善の取り組み査読

秋定直樹，牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2021年12月

難聴児に対する補聴の有用性と限界　医療と療育・教育連携の必要性

片岡祐子

小児耳鼻咽喉科 42 ( 3 ) 258 - 262 2021年12月

創部感染の制御が可能であった人工内耳植え込み術後の小児の1例査読

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸, 安藤瑞生

日本耳鼻咽喉科免疫アレルギー感染症学会誌 1 ( 3 ) 177 - 180 2021年12月

難聴児に対する医療・教育連携に向けた取り組み　教師対象パンフレットの作成

片岡祐子

日本耳鼻咽喉科頭頸部外科学会会報 124 ( 12 ) 1590 - 1593 2021年12月

難聴児に対する補聴の有用性と限界医療と療育・教育連携の必要性査読

片岡祐子

小児耳鼻咽喉科 42 ( 3 ) 258 - 262 2021年12月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本小児耳鼻咽喉科学会

先天性難聴の早期発見,補聴器・人工内耳装用に伴い,難聴児の聴取能や言語発達は向上し,近年インクルーシブ教育を受ける児が増加している。しかしながら難聴児の聴取は補聴器や人工内耳を装用していても正常聴力児と同等ではなく,言語発達や学習面,友人関係,行動面で問題が生じることは多い。また新型コロナウイルス感染症拡大予防策のマスク着用やソーシャルディスタンスにより難聴児の聴取や読話は困難となり,コミュニケーションにおける支障は増大している。しかしながら,特にインクルーシブ教育を受けている児では,聴取の困難さや抱えている問題を担任教師が正確には把握ができていない場合が多い。学校生活において適切な配慮や支援が受けられるよう情報提供が必要であると考え,当院では教師対象パンフレットを作成している。学齢期の難聴児の多岐にわたる問題に対し,医療,療育・教育,行政等多職種で連携して支援する体制の構築が必要である。(著者抄録)

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小児、思春期・若年がん患者に対する妊孕性温存療法現状と改善の取り組み査読

秋定直樹, 牧野琢丸, 門田伸也, 菅谷明子, 片岡祐子, 中塚幹也, 安藤瑞生

耳鼻咽喉科臨床 114 ( 12 ) 957 - 962 2021年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：耳鼻咽喉科臨床学会

当科で化学療法を施行した小児、思春期・若年(CAYA)世代がん患者20例を対象に、妊孕性温存に関する説明の実態調査を行った。その結果、妊孕性低下・消失について説明していた患者は2例のみであり、それぞれ17歳と23歳の未婚若年女性であった。一方、その他の女性5例(30歳台)や男性(13〜38歳)には説明が行われていなかった。また、妊孕性温存ガイドラインが出版された2017年の前後で妊孕性低下・消失について説明を実施した割合には著しい変化はみられず、妊孕性に対する配慮は担当医レベル、診療科レベルでも改善できる余地が十分にあると考えられた。

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その他リンク： https://search-tp.jamas.or.jp/index.php?module=Default&action=Link&pub_year=2021&ichushi_jid=J00580&link_issn=&doc_id=20211209280011&doc_link_id=10.5631%2Fjibirin.114.957&url=https%3A%2F%2Fdoi.org%2F10.5631%2Fjibirin.114.957&type=J-STAGE&icon=https%3A%2F%2Fjk04.jamas.or.jp%2Ficon%2F00007_2.gif

難聴児に対する医療・教育連携に向けた取り組み教師対象パンフレットの作成査読

片岡祐子

日本耳鼻咽喉科頭頸部外科学会会報 124 ( 12 ) 1590 - 1593 2021年12月

担当区分：筆頭著者記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会

難聴児の早期発見・療育,人工内耳装用に伴い,聴取能や言語発達は向上している.加えて,障害児の共生に向けた社会的体制の変化も伴い,近年地域の学校でインクルーシブ教育を受ける児は増加している.しかし,難聴児の聴取は補聴器や人工内耳を装用しても正常聴力児と同等ではなく,大勢でさまざまな方向からの聴取を要する学校生活の環境において多くの場面で支障がある.また学年が上がるとともに学習面の限界や学力低下,友人との関係性の問題などが出現する頻度が高く,留意や配慮を要する.加えて,新型コロナウイルス感染症拡大予防策のマスク着用やソーシャルディスタンスにより,さらにコミュニケーションの支障は増大している.しかしながら,担任教師であってもそれらの問題を正確には把握しにくく,適切な配慮や支援が施されないことが多い.われわれはこれまでに実施した難聴児・者への質問紙による調査結果をもとに,難聴児の直面している問題と支援について教師が実際に活用しやすい形式でまとめたパンフレット「難聴をもつ小・中・高校生の学校生活で大切なこと先生編」を作成した.難聴児の抱える問題は成長の段階で変化するため,乳幼児期の補聴機器のフィッティングや言語訓練を中心とした指導で完結すべきではなく,学齢に達しても専門的支援を継続する必要がある.本冊子が難聴児の育成の一助となることに期待するとともに,今後学齢期以降の支援を充実させるよう努めたい.(著者抄録)

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創部感染の制御が可能であった人工内耳植え込み術後の小児の1例査読

清水藍子, 菅谷明子, 片岡祐子, 檜垣貴哉, 假谷伸, 安藤瑞生

日本耳鼻咽喉科免疫アレルギー感染症学会誌 1 ( 3 ) 177 - 180 2021年12月

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本耳鼻咽喉科免疫アレルギー感染症学会

1日2回の生理食塩水洗浄と抗菌薬の保存的加療により、人工内耳植え込み術後の局所感染を制御できた小児の1例(1歳11ヵ月男児)について報告した。本症例で術後創部感染の保存的加療が可能であった要因として、「起炎菌がMRSAなどではなく、MSSAであったこと」「鼓膜所見や起炎菌から、中耳からの感染ではなく、皮膚からの感染であったため」「当院では、人工内耳植え込み術の際、minimum invasive surgeryを行っていること」が考えられた。

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Apocrine Hidrocystoma of the External Auditory Canal in a Child. 査読国際誌

Tomoyasu Tachibana, Tomoaki Sasaki, Yoji Wani, Yuto Naoi, Yuko Kataoka, Kazunori Nishizaki, Mizuo Ando

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 42 ( 8 ) e1181-e1183 2021年9月

Effects of Protective Measures against COVID-19 on Auditory Communication for People with Hearing Loss. 査読

Yuko Kataoka, Yukihide Maeda, Akiko Sugaya, Ryotaro Omichi, Shin Kariya

Acta medica Okayama 75 ( 4 ) 511 - 516 2021年8月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

WHO has recommended various measures to combat the COVID-19 pandemic, including mask-wearing and physical distancing. However, these changes impair communication for individuals with hearing loss. We investigated the changes in auditory communication associated with COVID-19 measures in 269 patients (male: 45.7%, female: 54.3%, median age: 54 y.o.). Most patients with hearing loss had difficulty engaging in auditory communication with people wearing masks, especially in noisy surroundings or with physical distanc-ing. These difficulties were noticeable in patients with severe hearing loss. Developing communication support strategies for people with hearing loss is an urgent need while COVID-19 measures are in place.

DOI： 10.18926/AMO/62404

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Hypertrophic rhinitis without sinusitis histologically compatible with IgG4-related disease 査読

Maki Akamatsu, Aiko Oka, Shinya Okada, Shogo Oyamada, Koichi Hirose, Shin Kariya, Yuko Kataoka, Kazunori Nishizaki, Kengo Kanai, Yoshihiro Noguchi, Mitsuhiro Okano

Otolaryngology Case Reports 19 100294 - 100294 2021年6月

Supraglottic subepithelial benign mass lesions: Focus on clinical features of sialolipoma-like lesion. 査読国際誌

Tomoyasu Tachibana, Shin Kariya, Yoji Wani, Yasutoshi Komatsubara, Yuto Naoi, Kazunori Kuroda, Soichiro Fushimi, Machiko Hotta, Katsuya Haruna, Tami Nagatani, Takuma Makino, Yuko Kataoka, Kazunori Nishizaki

Auris, nasus, larynx 48 ( 1 ) 154 - 160 2021年2月

記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: Sialolipoma has been classified as a benign soft tissue lesion in the 2017 World Health Organization classification of head and neck tumors. To our knowledge, only one case of laryngeal sialolipoma has been reported in the English literature. We conducted a retrospective study to identify clinical characteristics of supraglottic sialolipoma-like lesion and differentiate it from other supraglottic subepithelial masses. METHODS: Medical records of 16 patients with supraglottic subepithelial benign mass lesions who underwent histological evaluation between 2003 and 2019 were retrospectively analyzed. Sialolipoma-like lesion was defined as a local finding of a well-circumscribed gross mass with pathological presence of salivary gland-like parenchymal lobules with evenly interspersed adipose tissue. RESULTS: Eight patients showed histological positivity for sialolipoma-like lesion, 3 for amyloidosis, 2 for hemangioma, and 1 each for cyst, lymphoid hyperplasia, and chondrometaplasia. Sialolipoma-like lesion tended to be predominant among men; those affected had a mean age of 52.8 (range, 39-74) years. By contrast, among patients with amyloidosis, the ratio of men to women was 1:2 (100% vs. 33%; p = 0.055). Fiberscopic examination of all patients with sialolipoma-like lesions identified well-circumscribed, yellowish masses, closely resembling local amyloidosis findings. Sialolipoma-like lesion was associated with a significantly higher body-mass index (BMI; 27.4 ± 2.8 kg/m2) than amyloidosis (21.6 ± 1.4 kg/m2; p = 0.014). The transoral approach was used for lesion resection in all patients with sialolipoma-like lesion. No patient experienced postoperative recurrence. CONCLUSION: Laryngeal sialolipoma-like lesion might be more prevalent than was previously reported, and histological examination is important to differentiate it from amyloidosis. Supraglottic sialolipoma-like lesion must be differentially diagnosed in patients with high BMI presenting with well-circumscribed, yellowish supraglottic masses.

DOI： 10.1016/j.anl.2020.07.017

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両側難聴児・者が学校生活で抱える問題に関する調査の検討査読

片岡祐子, 菅谷明子, 中川敦子, 田中里実, 問田直美, 福島邦博, 前田幸英, 假谷伸

Audiology Japan 64 ( 1 ) 2021年

軽度~中等度難聴児への対応と課題思春期に学校生活で抱える問題招待

片岡祐子

小児耳鼻咽喉科 42 ( 1 ) 57 - 62 2021年

記述言語：日本語掲載種別：研究論文（学術雑誌）出版者・発行元：日本小児耳鼻咽喉科学会

小児難聴の中で身体障害者に該当しない軽度・中等度難聴児は約30%を占める。2010年から導入された軽度・中等度難聴児への補聴器購入助成制度は現在すべての都道府県で実施され,その恩恵により補聴器を購入する児は増加している。ただし補聴器を装用しても正常聴力児と同等の聴取が可能なわけではなく,インクルーシブ教育を受ける中で問題に直面する児は多い。その問題は言語発達遅滞や学力の低下,友人とのコミュニケーション,心理面など多岐にわたり,年齢が上がるにつれて顕著化,複雑化する。それらの課題に対して,聴取の環境調整や視覚情報の提示,教育面,心理・社会面も踏まえて個別に介入や支援を行うこと,教育者や周囲の理解を啓蒙することが必要である。難聴児が成長し社会参加をするに当たり必要なセルフアドボカシースキルを確立できるような指導や支援を行うべきある。(著者抄録)

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Prevalence and risk factors for delayed-onset hearing loss in early childhood: A population-based observational study in Okayama Prefecture, Japan. 査読国際誌

Yuko Kataoka, Yukihide Maeda, Kunihiro Fukushima, Akiko Sugaya, Akiko Shigehara, Shin Kariya, Kazunori Nishizaki

International journal of pediatric otorhinolaryngology 138 110298 - 110298 2020年11月

担当区分：筆頭著者記述言語：英語掲載種別：研究論文（学術雑誌）

OBJECTIVES: The aim of this study was to retrospectively document prevalence rates of delayed-onset hearing loss (DOHL) under 7 years old after passing the newborn hearing screening (NHS) program using its database in Okayama Prefecture, as well as records from Okayama Kanariya Gakuen (OKG, Auditory Center for Hearing Impaired Children, Okayama Prefecture, Japan). We explored the percentage of children with DOHL among all children who underwent the NHS and surveyed risk factors abstracted from their clinical records. METHODS: We collected data of 1171 children, who first visited OKG from April 2006 to March 2018. DOHL children were defined as bilaterally hearing-impaired children who were diagnosed under 7 years old after passing the NHS at birth. Based on the medical records, we investigated age at diagnosis, hearing levels, and risk factors. As population-based data of 168,104 children, the percentage of DOHL subjects was retrospectively calculated among the total number of children who underwent the NHS in Okayama Prefecture from April 2005 to March 2017. RESULTS: During the period, we identified 96 children with bilateral DOHL, of which 34 children had failed the NHS unilaterally and 62 had passed the NHS bilaterally. Among all children who underwent the NHS in Okayama Prefecture, the prevalence rate of DOHL in unilaterally referred infants was 5.2%, and 0.037% in bilaterally passed children. The prevalence of bilateral DOHL was 0.057% overall. Unilaterally referred children with DOHL were diagnosed at an average of 13.9 months, while bilaterally passed children with DOHL were diagnosed at an average of 42.3 months. Approximately 59.4% of children with DOHL had risk factors, among which family history of hearing loss was the most frequent. CONCLUSION: We propose the first English report of DOHL prevalence in the prefecture population in Japann, which is among the largest community-based population ever reported. The NHS is not a perfect strategy to detect all early-childhood hearing loss; therefore, careful assessment of hearing throughout childhood is recommended, especially in children with risk factors of hearing loss. Further interventional strategies must be established, such as regular hearing screening in high-risk children and assessments of hearing and speech/language development in public communities and nursery schools.

DOI： 10.1016/j.ijporl.2020.110298

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Clinical characteristics of subglottic cancer: emphasis on therapeutic management strategies for stage II subglottic cancer. 査読国際誌

Yasutoshi Komatsubara, Tomoyasu Tachibana, Yorihisa Orita, Takuma Makino, Kazunori Kuroda, Yuto Naoi, Yuko Kataoka, Yasuharu Sato, Shin Kariya, Kazunori Nishizaki

Acta oto-laryngologica 140 ( 9 ) 773 - 778 2020年9月

記述言語：英語掲載種別：研究論文（学術雑誌）

Background: Subglottic cancer (SGC) is extremely rare, as most laryngeal cancers are localized to the glottic region. Accordingly, the clinical characteristics of SGC have not been well characterized.Objectives: In the current study, SGCs were clinically evaluated, and the outcomes of radiotherapy (RT) in patients with stage II SGC were assessed.Materials and Methods: Medical data derived from 11 patients with SGC, who were treated at our hospital between 1995 and 2019, were retrospectively reviewed.Results: In our department SGC accounted for 3.9% of the 280 laryngeal cancer patients treated during the study period. At the time of SGC diagnosis, 9 (81.8%) had stage II cancer, 1 had stage III cancer, and 1 had stage IV cancer. Stage II SGC patients treated with concurrent chemoradiotherapy (CCRT) showed a significantly higher local control rate (p = .026) and laryngeal dysfunction free rate (p = .026) than those treated with RT alone. Salvage surgery, performed in 4 patients whose disease was not locally controlled with CCRT/RT, was successful in 3 patients.Conclusion: As a treatment strategy for stage II SGC, CCRT is an acceptable initial treatment for laryngeal function and preservation while salvage surgery is effective for recurrence after CCRT/RT treatment.

DOI： 10.1080/00016489.2020.1767303

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Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media. 査読国際誌

Shin Kariya, Mitsuhiro Okano, Pengfei Zhao, Yukihide Maeda, Yuko Kataoka, Takaya Higaki, Seiichiro Makihara, Jun Nishihira, Tomoyasu Tachibana, Kazunori Nishizaki

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 41 ( 3 ) 364 - 370 2020年3月

記述言語：英語掲載種別：研究論文（学術雑誌）

HYPOTHESIS: Macrophage migration inhibitory factor plays an important role in the expression of interleukin (IL)-1β and the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in lipopolysaccharide-induced otitis media. BACKGROUND: NLRP3 inflammasome and macrophage migration inhibitory factor are critical molecules mediating inflammation. However, the interaction between the NLRP3 inflammasome and macrophage migration inhibitory factor has not been fully examined. METHODS: Wild-type mice and macrophage migration inhibitory factor gene-deficient (MIF) mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline. The mice were sacrificed 24 hours after the injection. Concentrations of IL-1β, NLRP3, ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain and a pyrin domain), and caspase-1 in the middle ear effusions were measured by enzyme-linked immunosorbent assay. Temporal bones were processed for histologic examination and immunohistochemistry. RESULTS: In the immunohistochemical study using the wild-type mice, positive staining of macrophage migration inhibitory factor, NLRP3, ASC, and caspase-1 were observed in infiltrating inflammatory cells induced by lipopolysaccharide in the middle ear. The number of inflammatory cells caused by lipopolysaccharide administration decreased remarkably in the MIF mice as compared with the wild-type mice. The concentrations of IL-1β, NLRP3, ASC, and caspase-1 increased in the lipopolysaccharide-treated wild-type mice. The MIF mice with lipopolysaccharide had decreased levels of IL-1β, NLRP3, ASC, and caspase-1 as compared with the wild-type mice. CONCLUSION: Macrophage migration inhibitory factor has an important role in the production of IL-1β and the NLRP3 inflammasome. Controlling the inflammation by modulating macrophage migration inhibitory factor and the NLRP3 inflammasome may be a novel therapeutic strategy for otitis media.

DOI： 10.1097/MAO.0000000000002537

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「軽度~中等度難聴児への対応と課題」思春期に学校生活で抱える問題

片岡祐子

小児耳鼻咽喉科 41 ( 2 ) 2020年

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論文 - 片岡 祐子

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論文 - 片岡　祐子